LOCUS       c00055_gnlPro..        16607 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|EPMDDCDP_63.
ACCESSION   c00055_gnlPro..
VERSION     c00055_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-03 16:36:43
            Original ID  :: gnl|Prokka|EPMDDCDP_63
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16607
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..339
                     /locus_tag="ctg55_1"
                     /transl_table=11
                     /translation="MQTDIMLSKNNNILIIDAKYYSHMTQQQYGIHTLHSNNLYQIFTY
                     VKNKEFELRNYEHTVSGMLLYAQTDEDIIPNNTYHMSGNQISVLALDLNQDFSKISRTL
                     DDIAKNFL"
     protocluster    1..16607
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1634:6607]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1635..6607
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..16607
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16607
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(388..531)
                     /locus_tag="ctg55_2"
                     /transl_table=11
                     /translation="MNNAVSYAMDSQVIFQMFFSIVCIAAAIGVSILVLRFMRKFIDFL
                     LQ"
     CDS             756..944
                     /locus_tag="ctg55_3"
                     /transl_table=11
                     /translation="MPMKPKEMIRLLKKNGFIKISQNGSHVKMKNFKTGKQTTVPLHSK
                     DLKKGLEDAILKQAGLK"
     CDS             990..1379
                     /locus_tag="ctg55_4"
                     /transl_table=11
                     /translation="MKKLFYPAVFHIAEEGGYWVTFPDFPECLTQGENMQEAYDMAIDA
                     LGLILTDDINDHKELPEPSNITHVDDGVVVIIPYDYLEYNRKYHNKSIKKTLTIPEWLN
                     NEALRLNLNFSQILQDALLNKIQSR"
     CDS             1379..1483
                     /locus_tag="ctg55_5"
                     /transl_table=11
                     /translation="MAIILSFGNTAIIDYNILNKASNTIASPIHFRQV"
     CDS             complement(1635..3047)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: HMGL-like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: PYC_OADA"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg55_6"
                     /sec_met_domain="HMGL-like (E-value: 1.4e-43, bitscore:
                     139.9, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="PYC_OADA (E-value: 7.1e-59, bitscore:
                     189.5, seeds: 434, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEIKKKPVKIVETVLRDAHQSLIATRMTTEEMLPIVDKMDQVGY
                     HAVECWGGATFDACLRFLKEDPWERLRKLRDGFKNTKLQMLFRGQNILGYKPYPDDVVE
                     YFVQKSIANGIDVIRIFDCLNDLRNLQTAVDATKKEGGHAQIALSYTIGDAYTLDYWKK
                     TAKNIEEMGADSICIKDMAGLLVPNEATRLVTALKQATDIPIELHTHYTSGVGGMTYLK
                     AVEAGVDIIDTAISPFAMGTSQPATEVMAETFRGTEFDTGFDQKLLGEIADYFRPIREK
                     YLANGLMSPKVLGVNIKTLMYQVPGGMLSNLVSQLEQQGASDKFYEVLEEVPKVRKDFG
                     EPPLVTPSSQIVGTQAVLNVLTGERYKMITNESKALLRGEYGQTVKPMNKEVQKKAIGD
                     EKPITCRPADLLEPELSKIEAEMSQWKEQDEDVLTYALFPQVATEFFKYRAAQENKIDP
                     AKADVKNGAYPV"
     CDS             complement(3205..4329)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg55_7"
                     /sec_met_domain="OAD_beta (E-value: 2.1e-157, bitscore:
                     514.1, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYVVETMTNLAAQTGFAFLKPGNFIMILVALVFLYLAIAKGYEP
                     LLLVPISFGMLLVNLYPSIMEEGGLLHYFYLLDEWSILPSLIFLGVGALTDFGPLIANP
                     ASFLLGAAAQFGIYSAYFLAMLMGFNGKAAAAISIIGGADGPTSIFLAGKLGQTDLMGP
                     IAVAAYSYMSLVPIIQPPIMKLLTTEKERQIKMEQLRTVTKTEKIMFPIVVTVVVCLIL
                     PTTAPLVGMLMLGNLFRESGVVKQLSETASNALMYIVVIILGTSVGATTSAEAFLNVST
                     IKIVVLGLVAFAVGTAAGVLFGKLMCKVTGGKVNPLIGSAGVSAVPMAARVSQKVGAEA
                     DPSNFLLMHAMGPNVAGVIGTAVAAGTFMAIFGV"
     CDS             complement(4363..4731)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 66.6; E-value:
                     4.3e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg55_8"
                     /sec_met_domain="Biotin_lipoyl (E-value: 1.6e-21, bitscore:
                     66.6, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNYRITVNGVAYDVAVEELGAGEESAAPVSTPAAVPAPAKKAAP
                     KTSGSAGAVKITAPMPGKIVAVKAQAGASVKKGDAVLVLEAMKMENEICAAQDGVIASV
                     EVAVGDMVEGGDVLATMN"
     CDS             complement(4826..5170)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg55_9"
                     /sec_met_domain="OAD_gamma (E-value: 1e-27, bitscore: 87.2,
                     seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNVFEQALLNTLMGMGTVFAVLIFISLLISLFVYIPSIERALKNR
                     SSKKEKKAAQEERPAPKRPILEEVVEEEELVDDGELVAVITAAIMAANGGAAVSADKLV
                     VRSIKRVKRR"
     CDS             complement(5183..6607)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Vparvula"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg55_10"
                     /sec_met_domain="CT_Vparvula (E-value: 9e-138, bitscore:
                     450.5, seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGNSKMNARERIDYLFDDHSFVEVGGYVSARNTDYNLGAKKVEGD
                     GVITGYGVINDRMVYVYSQDASALGGSVGEMHAKKIASLYDLAMKTGAPIIGMLDCAGL
                     RLQEATDALHAFGTIFNKQAQASGMIPQISAVFGMCGGGSAVMSAMSDFTLMEKENGSL
                     FINSPNALAGNEESRQNTSGAQFQSEQAGNVDFVCETEEALLDQLRILVDVLPSDYEAE
                     DVYFDNDDDLNRVIPELNDAAYDAAYILKSISDNNMYIETKAAYAKEMVTAFIRLNGET
                     VGAVANQPVDGESVLTRNGLEKAERFIKFCDAFSIPLLTVTNVTGLRANAHEERKQALA
                     LAKFTTTLAQVSVPRINLIAGEAYGTAAEVMNSKAIGADFVLAWPQASVGMMDAEQAVR
                     IMYAEEINTDKNKTALIAEKTAEYAEGQSSALAAAKRGYIDDIIEPDATRKRLIAAYEM
                     LYGKKVTPVTKKHTAV"
     CDS             7330..7971
                     /locus_tag="ctg55_11"
                     /transl_table=11
                     /translation="MENRKIQFRSKACNLHLSAYPGHFATKHSHVNYFLDMTTLKVRQS
                     NAEEAARALVPLYKHNTVVDTIVCLDGTEVIGAFLAEKLTESGFFSYNQHKSIYIVTPE
                     IDSDGQMFFRKNIQPMIKDRNIIILMASVTTGITINRSWECIEYYGGKLQGISAIFSTL
                     SEYGNLPVNSLFTPNDIPTYHTYSKHDCPYCKSGQKIDALVNGHGYSELL"
     CDS             complement(7975..8160)
                     /locus_tag="ctg55_12"
                     /transl_table=11
                     /translation="VLRNFDYNLASSFSSKVVLLGKMKRLAQRNKIKLITILFLEDLVQ
                     FSSISSAKAASVSPAN"
     CDS             complement(8512..9162)
                     /locus_tag="ctg55_13"
                     /transl_table=11
                     /translation="VTLRIFTMFPQKKYYALRGKLEMIFGMVVFPVIAGVLQMFFTEIS
                     IICFGLTLGIIQVFTAFLTNRITMDELTQINNRTKLMQYLEGYMERHTEGEETDLHFLM
                     IDLDDFKWINDTYGHVEGDRALIRIAGVLKKTLAGHAGILARYGGDEFCIAGEMLREEA
                     EHLIKNLYENLEKANKQAASPYDIGMSVGCAQFTKEVRTIPDLVNSADEDMYL"
     CDS             complement(9750..10580)
                     /locus_tag="ctg55_14"
                     /transl_table=11
                     /translation="MLRKSREEILKDFKAQVAQGKILVGVGAGTGITAKCSEKADVDML
                     IIYNSGRFRMAGRGSLSGILSYGDANAIVQEMGQEVLPIVKKTPVLAGVCGTDPFRVMD
                     IFLKQLKEQGFNGVQNFPTVGLIDGKFRANLEETGMGYGLEVDMIREAHKLDMLTCPYV
                     FEPEQAKAMAEAGADILVAHMGLTTKGSIGAETALTLDDCCEKIREIIKAGKEVNPDIM
                     VICHGGPIADPEDAAYVINNVPEIDGFFGASSIERLASERGMTAQAAAFKAIEK"
     CDS             complement(10626..11852)
                     /locus_tag="ctg55_15"
                     /transl_table=11
                     /translation="MKTIAIAGTFDSKGEEFLYVKKLVEKLGLQTYMIHTGVFEPAFEP
                     DVSNREVAEAAGYDIDKIVEKKDRALATEALSNGMKVLVPQLYKEGKFDGILSFGGSGG
                     TSLVTPAMQKLPIGVPKLMVSTMASGDVERYVGTSDILMMPSIVDVAGINKISKIIFKN
                     AVLTIAGMVAGQEKLAEEETIEEKPLIAASMFGVTTPCVEQAKAVLEQAGYEVLVFHAT
                     GTGGKTMESLIESGFFTGVLDLTTTEWCDEVVGGILAAGEDRCRAAIRKKIPQVVSVGA
                     CDMVNFGPIDEVPKQFAGRNLYKHNPLVTLMRTSVEENKVIAEKLAERWNETENKMTLF
                     LPKQGVSMIDAKGQPFDGPEERKVLFDTLKNNISNENVEIVEMDNNINDEAFAKAAAQK
                     LMELINEGK"
     CDS             complement(12042..13265)
                     /locus_tag="ctg55_16"
                     /transl_table=11
                     /translation="MDREYILRLLRAQINVNGHIIGAAVGSGMTAKFAAMGGADLLLAL
                     SAGKYRIMGRSSFASYFCYGNSNEQVMEMGQRELFPIIKDTPIVFGLMANDPSLHLYEH
                     LKAIKEAGFSGIVNFPTMALIDGQFREALEEEGNTYKQEVEAIHLARYLDLFTIAFVTT
                     EEETRQMIEAGADVICVNLGLTKGGFLGPKRHLSIEDARRMTDKIYALCNEMNPDIIKM
                     IYAGPANTPIDMQYMYQNTECQGYIGGSTFDRIPTERAIYNTMKAFKSYGDFDRNNPMT
                     RLLDGDWNARTTVEFVQKYVEEHYMDEVILGDLALVAHVSPSYLSTRFKKETGASFTEY
                     LIRYRVNKAKNLLKEKQNRCREVAENVGYKDYAQFSKIFKKYVGLSPKEYQRMALEEEN
                     QYKHKKSE"
     CDS             13628..13885
                     /locus_tag="ctg55_17"
                     /transl_table=11
                     /translation="MNKFYKALEEKIKASGYPREISGRDVYNDICDQIEDKENGTYLVL
                     SKFEDDVTFEYHITIQDEGFNLGILTMRTPEGVFQTDFDE"
     CDS             14065..14997
                     /locus_tag="ctg55_18"
                     /transl_table=11
                     /translation="MNCHDPFYFFLIAFKFINNLFRTPLNGIIGIIDINSKSSDMELIE
                     ENRQKARCAAQQLLSLLNEVLDMSRLEHGETVLTNELFHLSELTAALQDTMQIHAADSG
                     IILICDSYTVPSNCERVYGSPIYIQKIFFNIIENAIKYNKTGGQIRWKTELIEQTESRL
                     TYKYTISDTGVGMNETTVTIILPFTIANAQKNSSAHGNGNADYLNNDEFTPSISDEDIT
                     AASLSGKQILLVEDNELNLEIAQFMLEDAGIIVTPVKDGSQALKAFLEKPAGTYYDMIL
                     MDIMMPVMNEHLTKPLNCEKLIATIVKFL"
     CDS             15423..16028
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg55_19"
                     /sec_met_domain="HAD (E-value: 2.8e-10, bitscore: 31.5,
                     seeds: 107, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEIVCLDLEGVLVPEIWIAFAEETGIPELKRTTRDEPDYDKLMKY
                     RLNILKEHGLGLKEIQETIAKIDPIPGAKEFLDKLRELTQVIIISDTFSQFAGPLMKKL
                     GYPTIFCNSLVVADNGEITDFKMRCEKSKYTTVKALQSIGYDTIASGDSHNDLGMIQAS
                     KAGFLFKSTDAIKAEYPEIPAYETYDELYAAIKGVIEA"
ORIGIN
        1 atgcagacag atattatgtt atccaaaaac aataacatac ttattattga tgccaaatat
       61 tattcgcata tgacccagca acaatacgga atacatactc tgcattccaa taatctttat
      121 cagattttta cctatgtaaa aaataaggaa tttgaattga gaaactatga acatactgta
      181 tcaggaatgc ttctttatgc acaaaccgat gaagatatta ttcctaataa cacctaccat
      241 atgagcggaa atcagatttc tgttcttgca ttagatttaa accaggattt ttcaaaaatc
      301 tccagaactt tagatgacat cgccaaaaat tttctttaaa atttttaaag gaagggacct
      361 aatatccctt ccttacttct attaccccta ttgtaacaaa aaatctataa acttcctcat
      421 aaagcgaaga accaaaatgg atacacctat agctgccgct atacatacaa ttgaaaaaaa
      481 catctgaaaa atcacctgac tatccatagc atatgaaact gcgttattca ttgtatctcc
      541 ccctgactat cttttgatac ttcattttac catatctctg tatttttatc aaaaattttt
      601 cattttcaaa attacatttt ttatgttatt ttacatttat tagttgtttt tcttcttaaa
      661 tatgatatac tattcctcac cagttgtatc accgagttct tgacacacgt atattatacg
      721 tattataata taattataga aaggggtggc atactatgcc aatgaaacca aaagaaatga
      781 taagattatt aaaaaagaat ggtttcataa aaataagtca aaatggttcc catgtgaaaa
      841 tgaagaattt taaaactggc aaacaaacaa cagttcctct tcatagcaaa gatttaaaaa
      901 aaggactaga agatgccatc ctaaaacaag cgggcttaaa atagccttat ttcatctata
      961 ataactcaca tacattggag gtatccatta tgaaaaaatt attttatcct gctgtatttc
     1021 atattgcaga agaaggcggt tattgggtga cttttcctga ctttcccgaa tgtctaactc
     1081 agggagaaaa tatgcaagaa gcctatgata tggctataga tgctttagga cttatcttaa
     1141 ctgatgacat taacgaccat aaagaacttc cagaaccgtc taacatcaca catgttgatg
     1201 atggagttgt cgtaatcatc ccatatgatt atttggaata taatcgaaag tatcataata
     1261 aatctatcaa aaaaacttta acaatccctg aatggttgaa taacgaagca ttgcgattga
     1321 atttaaactt ttcacagatt ttgcaggatg ctcttttaaa caaaattcaa tctcgttaat
     1381 ggctataatt ctttcatttg gtaatactgc aatcatagat tataatatac ttaacaaggc
     1441 atctaatacg atagcttcac ctatccattt ccggcaagtt taggttaaaa aacagaaccc
     1501 ccacaacttt atagatagca aatgtgatgt cggagcaagt aaaaatgcgg ctgagcattt
     1561 tctacgcagc gaaatcttca catgtgctat ctataaagtt gcgggggttc gtctgttttt
     1621 aatctaaatc aatcctacac cggatatgct ccattcttta catcggcttt tgcaggatca
     1681 atcttattct cctgtgccgc tctgtattta aagaattcgg ttgctacctg tgggaacaat
     1741 gcgtatgtaa gcacatcttc gtcctgttct ttccactggc tcatctctgc ctcgatctta
     1801 gataattccg gttcaagaag gtcggctgga cgacaggtaa ttggcttttc atcgccgatt
     1861 gcctttttct gtacttcttt attcattggt tttacggttt gaccgtattc tccacgaaga
     1921 agggcttttg actcgtttgt aatcatttta taacgctctc cggtaagtac atttaataca
     1981 gcctgtgttc cgacaatctg actggacggt gtaactaatg gtggttcacc gaaatcttta
     2041 cgtacttttg gaacttcctc taatacctca tagaacttat cagatgcgcc ctgctgctct
     2101 aactgagata cgaggttgga aagcattcct cccggtacct gatacattaa cgtcttgata
     2161 tttacgccaa gtacctttgg actcattaaa ccatttgcca gatatttctc acgtattggg
     2221 cggaaatagt ctgcaatctc gcctaaaagc ttctggtcaa atcctgtatc aaattctgta
     2281 ccgcggaatg tttcagccat aacttctgtt gccggctggc ttgttcccat tgcaaatgga
     2341 gatatggctg tatcaatgat atcgactcct gcttctactg cttttaagta agtcattcca
     2401 ccgacaccac ttgtatagtg tgtatgaagt tcgataggaa tgtctgttgc ctgctttaat
     2461 gcagttacaa ggcgagttgc ttcattcggc actaaaagtc ctgccatatc tttgatacag
     2521 atagaatctg ctcccatctc ttcaatattc ttagcagtct ttttccagta gtctaatgta
     2581 tatgcatcac cgattgtata ggagagggcg atctgcgcgt gtcctccctc tttctttgtt
     2641 gcatctacag cagtctgtaa gtttctaagg tcatttaaac agtcaaaaat acgaataaca
     2701 tcaattccgt ttgcaataga tttctgtacg aaatattcta caacatcgtc tggatatggc
     2761 ttatatccta agatgttctg tccacggaat aacatctgta actttgtatt cttaaagcca
     2821 tctcttaatt tacgaagtct ctcccatggg tcttccttta agaaacgcag gcaggcatca
     2881 aatgttgcac ctccccagca ttctactgca tgataaccaa cctgatccat cttatctacg
     2941 attggcagca tctcctctgt tgtcattctt gtagcaatca gagactgatg tgcgtcacgg
     3001 agaacggttt ctactatttt aaccggtttt ttcttaattt cggccataat atctcctttt
     3061 atttcaaatc acgtaactat ttgcgcttac aactgttatt atctaaaatt caacttgtaa
     3121 actatttata aatatcccct gtaacatttt ttacagatta tagccctata aataatgaat
     3181 tttaaataat caaataattc taaattatac tccaaaaatt gccataaatg ttccggctgc
     3241 taccgctgta ccgataactc cggcaacgtt tggtcccatc gcatgcatca gtaagaagtt
     3301 tgatggatct gcttccgcac caactttctg ggatacacgg gctgccatag gaacggcaga
     3361 taccccggca gaaccaatta atggatttac cttaccacct gtaaccttac acataagttt
     3421 accaaacagg acacctgctg cagtaccaac agcaaaagct acaagaccta atactacaat
     3481 cttgattgtg ctgacattta agaatgcctc tgcacttgtt gtcgcaccaa cggatgtacc
     3541 aagaataata actacgatgt acataagagc gttagacgct gtctctgaaa gctgttttac
     3601 tacgccggac tctctaaaaa ggttaccgag catcagcata ccaactaatg gtgctgttgt
     3661 aggaagaatc agacatacaa caactgttac aacgataggg aacataattt tctctgtttt
     3721 tgtaacggtt cttaactgtt ccatcttaat ctgacgttcc ttttctgtag taaggagctt
     3781 catgatcggt ggctgaataa ttggtacaag tgacatataa gaatatgccg ctaccgcaat
     3841 tggtcccatt aagtctgtct gcccaagctt tccggcaagg aaaatagaag taggaccatc
     3901 ggctccacca ataatggaaa ttgctgctgc tgcctttccg ttaaatccca taagcattgc
     3961 aagaaaatac gcgctgtaaa taccaaactg cgccgcagct cctagcaaga aacttgctgg
     4021 attggcaatc agcggaccga agtctgttag tgctccaacg cctaagaaaa tcagtgaagg
     4081 gagaatactc cattcatcta ataagtaaaa ataatgtaat aatccgcctt cttccataat
     4141 ggacggatat aagttaacca gcagcatacc aaaagaaatc ggcactaaca aaagtggctc
     4201 atatcctttg gcgatggcca gatataagaa gactaaagca accagtatca taatgaagtt
     4261 acctggcttt aagaatgcaa atccggtctg tgctgcgaga ttcgtcattg tctctacaac
     4321 ataactcata aatcttcctc cgttttattt tgcaaatatg ctctagttca ttgtagccag
     4381 tacatctccg ccttctacca tatctccaac tgctacttcc acacttgcga taacaccatc
     4441 ctgtgctgca cagatttcat tctccatctt catagcctct aatacaagaa cagcgtcgcc
     4501 cttctttaca gaagcacctg cctgtgcctt tactgctacg atcttacctg gcattggtgc
     4561 tgtaatcttt acggcaccgg cacttccgga agtctttggg gcagctttct tagctggagc
     4621 cggaacggct gctggtgtac ttaccggcgc tgcactttct tctcctgcac ctaattcttc
     4681 tactgctaca tcataagcaa caccattaac tgtaattcta taatttttca ttgtaaatcc
     4741 tcctgaatga ttttatgtac ttctaaaatc tttctatagc taacttttca aaactttata
     4801 aaaagattcc aagaatacat ttttgctatc ttctcttcac tctcttgatt gaacgaacga
     4861 ccaacttatc tgcactgact gctgctcctc cattcgctgc catgattgcc gctgtgatta
     4921 ctgcgacaag ttcaccatca tccacaagtt cctcttcttc cacaacttct tcaagaatcg
     4981 gacgctttgg agccggtctt tcttcctgcg cagccttttt ctctttctta gaagaacgat
     5041 tctttaacgc tctttcaata gatgggatat atacaaaaag agaaatcagt aaagaaatga
     5101 aaatcagtac tgcaaataca gttcccatac ccatcaaagt atttaataag gcttgttcaa
     5161 atacgttcat actctcacct cactatactg ccgtatgctt ctttgtcact ggagttactt
     5221 tctttccgta aagcatttca taagcagcga taagacgctt tcttgttgcg tccggctcga
     5281 tgatgtcatc tatatatcct ctctttgcag ctgctaatgc actgctctgt ccttctgcat
     5341 attccgcagt tttctctgcg ataagtgctg tcttattctt atctgtattg atttcctctg
     5401 catacatgat acgaactgcc tgttctgcat ccatcattcc tacagatgcc tgtggccatg
     5461 ccagaacaaa gtcagctccg atagctttag aattcattac ttccgctgca gttccataag
     5521 cctcgcctgc aatgagatta atacgaggta cactaacctg tgcaagtgtt gttgtaaact
     5581 tcgctaatgc gagcgcctgc tttctctctt catgtgcgtt ggcacgaagt cctgtcacgt
     5641 tcgttacagt aagaagagga atcgaaaatg catcacagaa cttaataaat ctttctgctt
     5701 tttcaagacc atttcttgtt aaaacggact caccatctac tggctggttt gcaaccgcac
     5761 ctactgtctc tccattcaga cggataaatg cagttaccat ctctttggca taggctgcct
     5821 ttgtctctat gtacatattg ttgtcagaaa tagattttaa aatgtaagcg gcatcatatg
     5881 cggcatcatt taactcagga ataaccctat ttaaatcatc atcgttatca aagtaaacat
     5941 cttctgcttc ataatcagaa ggaagtacat caacgagaat acgaagctgg tcaagaagtg
     6001 cttcttctgt ctcacataca aaatctacgt taccagcctg ctcagactgg aactgtgctc
     6061 ctgacgtatt ctgacgggat tcttcattcc ccgctaatgc attcggactg ttgataaaga
     6121 gactgccgtt ctccttctcc atcaatgtaa aatcagacat agcggacatt acggcacttc
     6181 ctcctccaca cattccaaat actgcagaaa tctgtggaat cattccagat gcctgtgcct
     6241 gcttattaaa aatcgttcca aaagcgtgaa gggcatctgt cgcttcctgt aatctaagtc
     6301 ctgcacaatc cagcattcca atgattggcg cacctgtttt catcgccaga tcataaaggg
     6361 aagcaatttt cttcgcatgc atctcaccta cggaacctcc aagtgcggaa gcatcctgac
     6421 tgtaaacata aaccatgcgg tcattaataa ctccgtatcc agtgataaca ccatcacctt
     6481 ctactttctt tgcaccgaga ttataatcgg tattacgagc ggaaacatat ccaccaactt
     6541 ccacaaaact gtggtcatca aacagataat caatgcgctc tctggcattc atttttgaat
     6601 tacccatatt ctttcctcca taaaaatgct atattgtata ccttgttgct ctttcattct
     6661 atgtaataat aacaaattat tatcatgtta gcaaccattt tctgttagtt atttaacatt
     6721 tattttattt tgcccattcc actaaacaaa atgaacattc tgcctatttg caaatttttt
     6781 aacaattctt tcaattttct ttctgaatct cctgtttttt tcaggaacgc ttgtgtattt
     6841 ttcctgtttt tctctatttt atctttaaaa ttctattttt gttttatatg tccattttta
     6901 tttcgttata attttaacgt attttgacat tcaattacta gttggttttt ctattttttc
     6961 gtcattttat acaaaacatt ctcattctat caaatatctt ccgtttttct tcataatttc
     7021 actcttattt ccatcattct tcttttctcg cttacattct cctcctgtct tttttaaatc
     7081 aaagatatag tatccaaaat caattttgaa ctatttttgt caaacttttt tcacaaacta
     7141 atagcgctcc ctttcatttt atacaactgt atatgcatac catgaagtat tttcaaaaaa
     7201 tcagaaagaa attataaact gtcaagaaaa gcctgtaatt ttgcacaaat actcctttat
     7261 tttttcacac aaaaaaggta taataaacaa aataaacaat tctttcacaa taaaggagga
     7321 ggacatctta tggaaaaccg caaaattcaa tttcgttcaa aagcctgtaa tctacatctt
     7381 tctgcctatc cgggacattt cgcaacaaag cattctcatg tcaactactt tttagatatg
     7441 acaacattaa aagtacgtca gtctaatgca gaagaagctg caagagcgtt agttccactt
     7501 tataaacata ataccgtcgt cgataccatc gtatgtcttg acggaacaga agtaatcggt
     7561 gcatttttag cagaaaagct tacagagagc ggattcttct cttacaacca gcataaatct
     7621 atctatattg ttactccaga aatagattca gatggtcaga tgttcttccg caaaaatatc
     7681 cagccaatga ttaaagatag aaatatcatt attttaatgg catctgtcac aactggaatc
     7741 acaatcaacc gaagctggga atgtatcgag tactatggtg gcaaactgca gggaatttca
     7801 gcaatattta gtacgctttc tgaatatggt aatcttcctg ttaattcgct gtttactcca
     7861 aatgatattc ctacttacca tacatatagt aagcatgact gcccatattg taagagtggt
     7921 cagaaaatcg atgctttggt aaacggacat ggatattcgg aattattata actactaatt
     7981 tgctggagaa acagacgccg ctttagcaga agatattgag ctgaattgta ccaggtcttc
     8041 taaaaaaaga attgttataa gtttgatttt gttccgttgc gctaaacgct tcattttgcc
     8101 taataaaaca accttgctcg aaaacgagct cgcaaggtta tagtcaaaat tccgcagcac
     8161 aaagtcacaa aattcaaact tataacaatt cttttttatt tatcatagtc ttcttacaat
     8221 tcagcataaa attttatttc agcggctgtc tgattttgat aacaaatagc aaattaatga
     8281 tttttgttgg aaagagaagg agattcccca tcctcaccaa ctgtggattt aggataatca
     8341 gaaaaaagaa acaataccat atcccagatg cggcttcgga gcgtgtttag gatgcggatg
     8401 agcatcttaa acacagcgac tacagagcag atgggatatg atattgtttc ttttttcgtc
     8461 tatacgaaat ctacaaatta gtatttacaa attagtacgt ttttgttctt ttcataaata
     8521 catatcctcg tctgcactat tcacaaggtc tggaatggtt ctgacttctt ttgtaaactg
     8581 tgcacagcca acagacattc ctatatcata tggagaggct gcctgtttat tcgctttctc
     8641 cagattttca tataagtttt taatcagatg ctccgcctct tcccgaagca tctctccggc
     8701 aatacagaat tcatctccgc catatcttgc aagaatacct gcatgtcctg ccagtgtttt
     8761 tttcaaaacc cctgctatcc ttatcaatgc cctgtctcct tcaacatgac catatgtatc
     8821 attaatccat ttaaaatcat caagatcaat catcaaaaaa tgtaaatctg tttcttcccc
     8881 ttctgtatgt ctttccatat atccttccaa atactgcatc agctttgttc ggttattaat
     8941 ctgcgttaat tcatccattg taattctatt tgtaagaaat gccgtaaata cctgaataat
     9001 tccaagtgtc agtccaaaac aaataataga aatctctgtg aaaaacattt gcaaaacacc
     9061 tgcaataacc ggaaatacga ccattccaaa tatcatctcc agctttccac gaagtgcata
     9121 atacttcttt tgaggaaaca ttgtaaaaat gcgaagtgtc accaaaaaaa tataaatata
     9181 aacaaagtga atagaagttt tgtatttaaa tggaagtggt aatgagttga gattgataac
     9241 aacagtctac tttttattct gaaattattg aaatattgct gtggtaatca ttgaaaaaga
     9301 gagcttttct atatttttta agttccattt ttatgagtta tatgtacata cctatgatta
     9361 ttccaaaagg tctagataaa gaagcagatt ctaactaagt ctgacatgat tatattatgt
     9421 tatccataat atttataaaa tcaaatttaa aataccgttt tttctctcta tactatatgt
     9481 agtcaaatca tatcttctat ccccagtcat tcttaaataa gcagaacacc tggtatctca
     9541 tcctcaaatt cccctccccc tgtttaattc accttctcaa gccacagcac agaagccatt
     9601 acccccaata aggcatattt gtggtctcgg agcaaggttt ggatgcgagc gcatgagcga
     9661 acattcaaac cgccacgact aaaatcacaa atatgcctta ttgggggtaa tggcttcgtc
     9721 tatagttcac ttaatgaatt aaatagtaat tacttctcga ttgccttaaa cgctgctgcc
     9781 tgcgctgtca ttcctctttc agaagcaagt ctttcgatag aagatgctcc gaagaatcca
     9841 tcgatttcag gtacattgtt aattacatat gctgcatctt ctgggtctgc aattgggccg
     9901 ccgtggcaga taaccatgat atctggattt acttcttttc cagctttgat aatctcacga
     9961 atcttttcgc agcagtcatc taatgttaat gctgtttctg ctccgataga accttttgtt
    10021 gtcaatccca tatgtgctac aaggatatct gctccagctt ctgccattgc tttcgcctgt
    10081 tctggttcaa atacatatgg acatgttaac atatcaagct tatgtgcttc acgaatcatg
    10141 tctacttcaa gaccatatcc cattcctgtt tcctctaaat ttgcacggaa tttaccatcg
    10201 ataagaccaa ccgtagggaa gttctgtaca ccgttaaatc cctgctcttt taactgtttt
    10261 aagaaaatat ccattacacg gaatgggtct gtaccacata caccggcaag tactggagtt
    10321 ttctttacga taggaagtac ttcctgtccc atttcctgaa cgatggcatt ggcatcaccg
    10381 taagaaagaa ttcctgataa agaacctctt cctgccattc tgaaacgtcc agagttgtaa
    10441 atgatgagca tatcaacgtc tgctttttca ctacattttg ctgtaatacc tgtaccagct
    10501 ccaacaccta ctaagatttt cccctgtgct acctgtgcct taaagtcttt taagatttct
    10561 tctctgcttt ttcttaacat aatcgttacc tcctgttttt taaatgattt tatttatgta
    10621 atttattatt taccttcgtt aatcagttcc attaattttt gtgcggctgc cttggcaaat
    10681 gcctcatcat taatattgtt atccatctcg acgatttcaa cattttcatt agagatatta
    10741 ttttttaaag tatcaaataa tacttttctt tcctctggac catcaaatgg ctgtccttta
    10801 gcatcaatca ttgaaacacc ctgttttgga aggaagagtg tcatcttatt ctctgtctca
    10861 ttccatctct ctgctaactt ctcagcaatt actttatttt cctcaacgga tgtacgcatc
    10921 agagtaacta atggattgtg tttgtaaaga tttctgcctg caaactgctt tggcacctca
    10981 tcaattggcc caaaatttac catatcacat gcaccaacag aaacaacctg tggaatcttt
    11041 ttgcggatgg cagctctgca tctgtcttct ccggcagcaa gaatacctcc gactacctca
    11101 tcgcaccatt cagttgtggt gagatctaac actccggtaa agaatccaga ttcaatgagg
    11161 gattccattg tttttccgcc tgtacctgtt gcatggaaaa caagcacttc atatcctgcc
    11221 tgttccaaca ctgcttttgc ctgttctaca catggagttg taacaccaaa catagatgct
    11281 gcaattaaag gtttctcctc tatagtttct tcttctgcaa gtttttcctg tccagctacc
    11341 attcctgcaa ttgttaatac tgcatttttg aaaataattt ttgaaatctt attaattcct
    11401 gccacatcaa caatagacgg catcattaag atgtcacttg ttccaacata tctttcgaca
    11461 tctccagaag ccatcgtaga aaccatcagc tttggtacac caatcggcag tttctgcatt
    11521 gccggagtta ctaatgaagt tcctcctgaa ccaccaaaag aaagaattcc atcaaatttg
    11581 ccttctttgt aaagctgtgg aactaaaacc ttcataccat tagaaagtgc ttccgtcgct
    11641 aatgctctgt cttttttttc tacgatttta tcaatatcgt atcctgctgc ctctgcaacc
    11701 tccctgtttg atacatctgg ttcaaacgct ggctcaaata caccagtatg aatcatatat
    11761 gtctgaagtc caagtttttc tactaatttt tttacatata gaaattcttc tccttttgaa
    11821 tcaaaggttc ctgcaattgc gattgtcttc atcttttctc ctttctcctt gtaactctcc
    11881 cattgtgaaa aatattctga caacttaata tataattcat gaattttaaa aaagaagtag
    11941 aattttgtct ttgttgtgac tctattctac ttctttttct gatgtaagta aatgtgttta
    12001 tatttgtatc tcttgtattt atattttaaa cactactatc tttattcact tttcttgtgt
    12061 ttatattggt tttcctcttc taaagccatt ctttgatact ctttcgggga taaccccaca
    12121 tatttcttaa atatctttga aaactgtgcg taatccttat atccgacatt ttctgccact
    12181 tcccggcagc ggttctgctt ctcttttaac agattctttg ccttattcac ccggtaacga
    12241 atcagatatt ctgtaaaact tgccccagtt tcctttttaa aacgggtact tagataagaa
    12301 ggggacacat gtgcaaccag cgccagatcc ccaagaataa cctcatccat gtaatgttcc
    12361 tctacatatt tctggacaaa ctccaccgtc gttcttgcat tccagtctcc atcaagtaaa
    12421 cgggtcatcg gattattcct gtcaaaatct ccgtaacttt taaaagcttt cattgtatta
    12481 tatatcgccc gctctgtagg aatcctatca aaagtagaac cgccgatgta cccctgacat
    12541 tctgtattct gatacatata ctgcatatca atcggcgtat tggctggccc agcatagatc
    12601 atttttataa tatctggatt catctcattg cagagtgcat aaatcttatc cgtcatcctt
    12661 cttgcatctt caatagaaag atgtcttttc ggcccaagaa atcctccttt cgtcaacccc
    12721 agattcacac aaatcacatc tgcccctgcc tcgatcatct gccttgtttc ttcttctgtc
    12781 gtaacaaagg caatcgtaaa taaatcaaga tatcttgcca gatgaatcgc ctctacttcc
    12841 tgtttataag tatttccctc ttcctctaac gcctcccgaa actgtccatc aatcaatgcc
    12901 atcgtcggaa aatttacaat tccagaaaat ccagcttcct taattgcttt taaatgttcg
    12961 tacaaatgaa gagatggatc attggccatc agtccgaata caatcggtgt atcttttata
    13021 ataggaaaaa gttcccgctg ccccatctcc attacctgct cattactatt tccataacaa
    13081 aaatagctgg caaaagagct ccgtcccata atacggtact ttcccgcact gagtgccaat
    13141 aataagtctg ctcctcccat tgccgcaaac ttagccgtca taccagagcc tacagccgct
    13201 ccgataatat gaccatttac attaatctgc gcgcgcaata atcttaaaat atattctcta
    13261 tccatctcat cactttcttt ttacctaaac atctctttaa taacaactga gttttacccg
    13321 aaccgttctt tcctgttaat agaagatgct gacgtttttc tgaatttaat tttattttta
    13381 tatctgataa atagtataat ttttctatgt caatttcgct gataagatat tccctcaatt
    13441 ctgtccttcg aatttctatt atttttgcat gacactattt tattaaaact tttacatcaa
    13501 aatggtattg tcttagcaaa acaaatattc tatactatta ttattatagc atggcacaaa
    13561 acccttttca aaccatctat tttaaattat catattaaaa caacataacc acgaaagcga
    13621 ggaaaccatg aacaaatttt ataaagcact cgaagaaaaa ataaaagcat ccggctaccc
    13681 aagagagatt tccggaagag acgtatataa tgatatctgt gatcagattg aagataagga
    13741 aaatggaacc tatctggtgt tatctaaatt tgaagatgac gtaacttttg agtaccatat
    13801 tacgattcaa gatgaaggat ttaatcttgg gattttgaca atgagaacgc cagagggtgt
    13861 cttccaaaca gattttgatg aataaataag taattttgtt acacatccaa aattagcccg
    13921 cagaacgata tataagccat atttgtggcc tcggagcaaa tgttgaatag tagcgtttta
    13981 agcgagtatt caacacgccg cgactaaagt cactaatatg gcttatatcg gattgcccct
    14041 gtatggagac aggatatcca atccatgaat tgccatgacc ccttctactt cttcctcatt
    14101 gcctttaaat tcatcaataa tcttttccgc actcctttaa acggaattat cggtatcatt
    14161 gatatcaaca gcaaatcaag cgatatggaa ttaatcgagg aaaaccgcca aaaggcacga
    14221 tgtgccgcac agcagctttt aagcctgtta aatgaagtgc ttgacatgag tcgtttagaa
    14281 cacggtgaaa cagttcttac aaacgaattg tttcaccttt ctgaactgac cgccgctctc
    14341 caggatacga tgcaaattca tgctgcggac tccggcatta ttctcatctg tgacagttat
    14401 acggttccat ccaactgtga acgggtttat ggcagcccaa tctatattca gaagattttc
    14461 tttaacatta tagaaaatgc aatcaaatac aataaaactg gtggacagat tcgctggaaa
    14521 accgaattaa tcgaacagac agaaagcaga cttacttaca aatatacgat ttccgatacc
    14581 ggtgtcggca tgaatgaaac gactgtcact attatcctgc cgtttactat cgcaaatgca
    14641 caaaagaatt cttcagccca tggtaacggc aacgcagatt acttaaataa tgatgaattt
    14701 acgccatcta tttccgatga agacatcacc gctgcgtctc tttctggtaa acaaatttta
    14761 ctcgttgagg ataatgagct aaatctcgaa attgcccagt ttatgttaga agatgccgga
    14821 attattgtca cccctgtaaa agatggttca caagcattaa aagcattttt agaaaagcct
    14881 gccggtacct actatgacat gattctgatg gatattatga tgccggtgat gaatgagcat
    14941 ttaacgaaac cgttgaattg tgagaaactg attgcaacaa ttgtgaagtt tttgtaactg
    15001 gtacaaagtt ggcgagctgt ctttggctgg gggcagctgg atagttactt agtttactgc
    15061 tagagcgtgt ttgaaaaaca tatcgctcca acagccaaaa aattcttaga atttttgaaa
    15121 aataaaaatt tttatggaga tttttcaggt ttcctactat aatagtgttt aatatggctt
    15181 gaacttaact ggagaatatt tgaaaaagca aaaagtaatt tacacatcac atttgcgaga
    15241 atggtttttc aaacacgctc tagcatgagc catatccgat tgtgtttgaa gatactaaaa
    15301 tgattttcaa tacacactca cattactaga aagataagac gtggtatttt acatactgtt
    15361 ttgtagtgtt acttattgtt aaataccgca actgacacat cagaaatgga ggaaacaaag
    15421 acatggaaat tgtttgttta gacttagaag gcgtattagt accggaaatc tggattgcat
    15481 tcgcagaaga gactggaatt ccagagttaa agagaacaac cagagatgaa ccagattacg
    15541 ataagttaat gaagtatcgt cttaacattt taaaagaaca tggtcttgga ttaaaagaaa
    15601 ttcaggaaac aatcgcaaag attgacccta ttcctggagc aaaagaattc ttggataaat
    15661 taagagaact gacacaggtt atcattatca gtgatacatt ctcccagttt gcaggtccgc
    15721 ttatgaagaa gcttggttat cctactatct tctgtaactc tctcgttgta gcagataacg
    15781 gagaaatcac tgactttaaa atgcgttgcg aaaaatctaa atatactaca gttaaagctc
    15841 tccagtccat cggttatgat accatcgcca gcggagacag tcacaatgat cttggtatga
    15901 ttcaggcaag taaggctgga tttttattca agagtacaga tgctattaag gctgagtatc
    15961 cagaaattcc ggcatatgaa acatatgatg agttatatgc tgcaattaag ggagtaattg
    16021 aagcgtagtt tgtgatagac agacgagcta tcccctccta tctgtgactt tcgttgcggc
    16081 atgttaaatg ttctcatttt tatttgccta aatccaatca ctatcaatcc caaagagaaa
    16141 agctgcccta tattgtgacc tcggagcaag gtttgggtgc gtgtacatga acgagcattc
    16201 aaaccgctgc aaggtcacaa tataggacag cttttctctt tggatgcgtc agcctattaa
    16261 tgaattaaat agccatcccc atctttactg ctttttctaa aaattcctga tgattttcga
    16321 ggtcatctgc tcctgcaagt cccggacaaa ggagtgttcc tcccttatca aaatgcagta
    16381 actcacaaag ctgttcataa gcatgaacaa cgtcattaaa cattgccgaa tctggattag
    16441 cagatgctgc aatgagatat aaatctttga tatgtaaagt ttctcttccc tttggaaaac
    16501 taaactgata aaagcggtca atcgctgttt taatctgtga tgtaaagccg ctccagtaga
    16561 caggagatgc caatacaaga acatctgctt ctcgcattag ttcattc
//
