LOCUS       c00216_gnlPro..        14341 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KOGMLDFM_239.
ACCESSION   c00216_gnlPro..
VERSION     c00216_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-03 16:59:50
            Original ID  :: gnl|Prokka|KOGMLDFM_239
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 36790
            Orig. end    :: 51131
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14341
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[46790:51024]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..14234
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..14341
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14341
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(631..759)
                     /locus_tag="ctg216_25"
                     /transl_table=11
                     /translation="MHKVLRGGSYYTFEKYCKVTSRYGVTPQRWDIDYGLRLVVSL"
     CDS             complement(775..906)
                     /locus_tag="ctg216_26"
                     /transl_table=11
                     /translation="MPRLLPTRKMILMKKRIYSVNEEVFGFRRMIVIIAELISSDRY"
     CDS             955..2013
                     /locus_tag="ctg216_27"
                     /transl_table=11
                     /translation="MKKRLVGVALVLAAVSLGSIQPVEACTRAVYIGPDQMVITGRTMD
                     WKEDIMTNIYVFPRGIQRAGHNKDKTVNWTAKYGSVIATGYDIGTCDGMNEKGLVASLL
                     FLPESIYSLPGDTRPAMGISIWTQYVLDNFATVREAVDELKKETFRIDAPRMPNGGPES
                     TLHLAITDETGNTAVLEYLDGKLSIHEGKEYRVMTNSPRYDYQLAINDYWKEIGGLQML
                     PGTNRASDRFVRASFYIHAIPQTADAKIAVPSVLSVMRNVSVPFGINTPEKPYISSTRW
                     RSVSDQKNKVYYFESTLTPNMFWLDLKKIDFSPKAGIKKLSLAKGEIYAGDAVKDLKDS
                     QSFTFLFQTPVM"
     CDS             complement(2127..3491)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M20"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg216_28"
                     /sec_met_domain="Peptidase_M20 (E-value: 9e-39, bitscore:
                     124.6, seeds: 360, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNEIQKYIIAHEPEMMNDLFSLIRIPSISALPEHHDDMLACAERW
                     AQLLLEAGADEALVMPSKGNPIVFAQKMVDPDAKTVLVYAHYDVMPAEPLELWKSQPFE
                     PEIRNGYIWARGADDDKGQSFIQVKAFEYLVKNGLLKNNVKFIFEGEEEIGSPSLEAFC
                     EEHKELLKADVILVSDTSMLGAELPSLTTGLRGLAYWEIEVTGPNRDLHSGHFGGAVAN
                     PINTLCQIISKVTDADGRITVPGFYDDVEEVPQAEREMIAHIPFDEKKYKEAIGVKELF
                     GEKGYSTLERNSCRPSFDVCGIWGGYTGEGSKTVLPSKAYAKVSCRLVPHQDHHKISQM
                     FAEYISSIAPETVQVKVTPMHGGQGYVCPISLSAYQAAEKGFEIAFGKKPLAVRRGGSI
                     PIISTFEQVLGIKTVLMGFGLESDAIHSPNENFSLDIFRKGIEAVIEFHQEYARR"
     CDS             complement(3491..4567)
                     /locus_tag="ctg216_29"
                     /transl_table=11
                     /translation="MFNSFGNIFRLTSFGESHGKGVGGVIDGFPAGIVIDEEFVQQELN
                     RRRPGQSILTTARKEADKVEFLSGIFEGKSTGCPIGFIVWNENQHSNDYNNLKNVYRPS
                     HADYTYTVKYGIRDHRGGGRSSARETISRVVAGALAKLALRQLGISITAYTSQVGPIKL
                     EGTYSDYDLDLIETNDVRCPDPEKAKEMADLIYKVKGEGDTIGGTLTCVIKGCPIGLGQ
                     PVFGKLHAALGNAMLSINAAKAFEYGEGFKGLKMKGSEQNDVFYNNNGRIETHTNHSGG
                     IQGGLSNGQDIYFRVVFKPIATLLMEQETVNIDGIDTTLKARGRHDACVLPRAVPIVEA
                     MAAMTILDYYLLDKTTQL"
     CDS             4730..5296
                     /locus_tag="ctg216_30"
                     /transl_table=11
                     /translation="MKKNLLYLLALVCSLTFFAACSSDDDDSDNKNNGNPPEEEAAITA
                     PDVVGTYWGNLDISMIPDGSDQEIVIGDGIEKFITLSQVSNTEVKIELKEFELFINQQI
                     LKFGDIVVDKCEVKKGEGVSTFTGQQDLTFEGNAAALGTCPVTVTGTVEDGNADMTINV
                     KVSTLQQTVKVTYSGVKQVAESGGN"
     CDS             complement(5402..6187)
                     /locus_tag="ctg216_31"
                     /transl_table=11
                     /translation="MKIYPYIFSLLACIGIALPGYSQVDRNETLIRSALHGLEYEIKAG
                     FSIGGTAPLPLPVEIRSIDGYNPTLAISIGGEVTKWIAVQNKLGIIVGLRLENKAMTTE
                     ATVKNYNMEILGQGGERISGVWTGGVKTKVHTAGLTIPLMATYKLSNRWNIKAGPYFSY
                     LLSREFSGHVYEGYLREDDPTGPKVEFTDGKIATYDFSDDLRHFQWGLQVGAGWRAFKH
                     LNVYADLTWGLNDIFKSDFNTITFAMYPIYLNIGFGYAF"
     CDS             complement(6309..7394)
                     /locus_tag="ctg216_32"
                     /transl_table=11
                     /translation="MKAKHVIVYLLLAIVSSSCIREEALNAEADILSCILPGVAMTTSP
                     IINNNSITIFVGPGTDISELKPEFTLTPGATISPLSGTERNFNTPQEYTVTAADGIWKK
                     AYTVSVIDTELATNYNFEDTLGGKKYYIFVERERDKVVMEWASGNAGYAMTGVAKTADD
                     YPTFQITDGKAGKCLSLVTRSTGFFGQLAGMPIAAGNLFIGSFDVSNAMSNPLKATKFG
                     LPFRHVPTYLAGYYKYKAGDQFTEGGKPVNGKRDICDIYAIMYETSESVPTLDGTNAFT
                     SPNLISTARINNAKETNEWTYFKLPFITLPGKFIDKEKLRDGKYNIAIVFTSSLEGDHF
                     NGAIGSTLLIDEAELIYHSEN"
     CDS             7528..8814
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SDH_alpha"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg216_33"
                     /sec_met_domain="SDH_alpha (E-value: 3e-62, bitscore:
                     201.9, seeds: 645, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTESERRQIIELIKKEVIPAIGCTEPIAVALCVAKAAETLGAKPE
                     KIEVLLSANILKNAMGVGIPGTGMVGLPIAVALGALIGKSDYQLEVLRDCTSEAVEQGK
                     LFIAEKRICISLKEDITEKLYIEVICKTEDKTAKAIIAGGHTTFIYIAKNEQTLLDKQQ
                     TVSEKEEEASPELNLRKVYDFALTAPLDEIRFILDTARLNKAAAEQAFKGNYGHSLGKM
                     LRGTYEHKVMGDSVFSHILSYTSAACDARMAGAMIPVMSNSGSGNQGISATLPVVVFAE
                     ENGKSEEELIRALMLSHLTVIYIKQSLGRLSALCGCVVAATGSSCGITWLMGGNYNQVA
                     FAVQNMIANLTGMICDGAKPSCALKVTTGVSTAVLSAMMAMENRCVTSVEGIIDEDVDQ
                     SIHNLTRIGSQAMNETDKMVLDIMTHKGC"
     CDS             complement(8942..9679)
                     /locus_tag="ctg216_34"
                     /transl_table=11
                     /translation="LQLLSNCAPHFLFLTKALNNLKFTLPIPEYKQIIRIFVDPYLREL
                     LIRNKKDQMETVENKYITVAYKLYTMEDGEKELFEEAKAEHPFQFISGLGTTLEDFENQ
                     ITALSKGDKFDFTIPADKAYGQYDEQHVIDLPKNIFEIDGKFDSERIKEGNIVPLMTGD
                     GQRVNASVVEIKPDVVVVDLNHPLAGADLIFEGEILESRPATNEEIQELVKMMSGEGGC
                     GCGCDSCGDGCGDDCGCEGGHCH"
     CDS             10001..11800
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg216_35"
                     /sec_met_domain="ILVD_EDD (E-value: 2.3e-216, bitscore:
                     710.6, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKQLRSSFSTQGRRMAGARALWAANGMKKNQMGKPIIAIVNSFT
                     QFVPGHVHLHEIGQLVKAEIEKLGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADS
                     VEYMVNAHKADAMVCISNCDKITPGMLMAAMRLNIPAVFVSGGPMEAGEWNGQHLDLID
                     AMIKSADESVSDQEVANIEQNACPTCGCCSGMFTANSMNCLNEAIGLALPGNGTIVATH
                     ENRTQLFKDAAELIVKNAKLYYEEGDESVLPRSIATRQAFLNAMTLDIAMGGSTNTVLH
                     LLAVAHEAEVDFKMDDIDMLSRKAPCLCKVAPNTQKYHIQDVNRAGGIIAIMDELAKGG
                     LIDTSVRRVDGMSLAEAINEYSITSPNVSEKAIKKYSSAAGNKFNLVLGSQGMYYKELD
                     KDRANGCIRDLEHAYSKDGGLAVLKGNIAQDGCVVKTAGVDESIWKFTGPAKVFDSQEA
                     ACEGILGGRVVSGDVVVITHEGPKGGPGMQEMLYPTSYIKSRHLGKECALITDGRFSGG
                     TSGLSIGHISPEAAAGGNIGKIVDGDIIEIDIPARKINVRLTDEELAARPMTPVTRDRY
                     VPKSLKAYASMVSSADKGAVRII"
     CDS             11853..13619
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg216_36"
                     /sec_met_domain="TPP_enzyme_C (E-value: 5.4e-47, bitscore:
                     150.7, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVNHSFSTVISQLSFIIYQLSTNMKDLITGAEALMRSLEHQGVT
                     TIFGYPGGSIMPVFDALYDHQNILNHILVRHEQGAAHAAQGYARVSGDVGVCLVTSGPG
                     ATNTVTGIADAMIDSTPIVVIAGQVGTGFLGTDAFQEVDLVGITQPITKWSYQIRRAED
                     VAWAVARAFYIARSGRPGPVVLDFAKNAQVEKTKYEPTKVDFIRSYVPVPDTDEESVQA
                     AAELINNAERPLVLVGQGVELGNAQSELREFIEKADMPAGCTLLGLSALPTEHPLNKGM
                     LGMHGNLGPNINTNKCDVLIAVGMRFDDRVTGNLATYAKQAKVIHFDIDPAEVNKNVKV
                     DVAVLGDCKETLASVTKLLKKHTHTEWIDSFKEYEKVEEEKVIRPELHPATNSLSMGEV
                     VRAVSDATHHEAVLVTDVGQNQMISARYFKYTKERSIITSGGLGTMGFGLPAAIGATFG
                     APERTVCVFMGDGGLQMNIQELGTIMEQKAPVKIICLNNNYLGNVRQWQAMFFNRRYSF
                     TPMLNPDYMKVASAYDIPSKRAFTREELKEAIAEMLATDGPFLLEACVVEEGNVLPMTP
                     PGGSVNQMLLEC"
     CDS             13677..14234
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg216_37"
                     /sec_met_domain="ALS_ss_C (E-value: 7.5e-19, bitscore:
                     59.1, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDKTLYTIIVHSENIAGLLNQVTAVFTRRQINIESLNVSASSIK
                     GVHKYTITAWTDKDIIEKVVKQIEKKIDVIQAHYFTEDEIYFHEIALYKVSTPAFQENP
                     EASKLIRRYNARIVEVNPVFSIVEKNGMSEDITSLYGELKALNCVLQFVRSGRVAITTS
                     CFERVNEFLDGREAMYNQSKKQ"
     CDS             14240..14341
                     /locus_tag="ctg216_38"
                     /transl_table=11
                     /translation="MNEENRIGTYQFVAEPFHVDFNGRLTMGVLGNHL"
ORIGIN
        1 tatcgctatg tcaaggtgtt tggtatggta gacaggggaa taaagaaaaa catcttgcaa
       61 gataaactgg ctttgtatgt gaactactta tacgattgtt gttatgctga tgaaagcctc
      121 aaacaaaaag aggtattgaa gaagatgtat gaatcctatg gtaaccattc tgccgacttt
      181 attttgatga accaccaggc gcagtatttg tggaataaac taagcgagcc gttgcgttgg
      241 gctaaccgct atcagctgga tgcctatagt gtattttgtc gcacactggg ctacggcatc
      301 agacggagtg accactcacc ggcacacata tccgaatcta tgttcaatga agatctgcca
      361 gctcaagttt tgtatctgtt agtacgcatg gagaagtacc gatggaatgc cgagcgtacg
      421 gtggccggct ggagacgtgc taaggtgaag gataaggtat ttttgcaaca tcctcttatt
      481 atgcctttca gcgaattact acaaaagtat cccgaggagg tagagaagga tgctgatgta
      541 atttataatc tgccctacat actggcattg ggaggatatg agctttatag attggccgat
      601 taataagccg acttaacatt tatacataag ttagagagac actactaacc gcaacccgta
      661 atcaatatcc caccgttgtg gggtcactcc ataacggctg gtgactttac agtatttctc
      721 gaaggtgtaa taactgcctc cgcgtaatac tttatgcata tccttttcat ttatttaata
      781 tctatcgcta gaaatgagtt ctgcgatgat aactatcatg cgtcgaaaac caaaaacttc
      841 ctcattcact gaataaattc tttttttcat taaaatcatc tttcttgtag gcaataatcg
      901 tggcatattt gttatttata aaatgagagt atcaattatt taaatagaaa gaatatgaag
      961 aaaagattag taggagttgc attggtgttg gctgccgtct ctttggggag tatacagcct
     1021 gtggaagcat gtacgcgtgc agtatacata ggtcctgatc agatggtgat aacggggcgt
     1081 accatggact ggaaagaaga tatcatgacg aatatctatg tgtttccacg tggtattcag
     1141 cgtgcgggac ataacaagga taaaacggtg aactggactg ccaaatacgg aagtgtaatt
     1201 gccacaggat atgatattgg tacttgcgat ggaatgaacg agaaaggatt ggtggcgagt
     1261 ctgcttttct taccggaatc tatttactct cttcccggtg atacccgtcc ggcaatggga
     1321 atcagcattt ggacacagta tgtgcttgat aactttgcta cggtacgcga agccgtggat
     1381 gaactgaaaa aagagacttt ccggattgat gctccccgta tgccgaatgg gggaccggaa
     1441 tctaccttgc atctggctat aaccgatgaa actgggaata cggctgtatt ggaatatttg
     1501 gatggaaaat taagtattca cgaagggaaa gaataccggg tgatgacaaa ttctccccga
     1561 tatgactatc aattggctat taatgattat tggaaagaaa ttggtggctt acagatgcta
     1621 ccgggaacaa atcgtgcgag tgaccgcttt gtcagggctt ctttctacat tcatgccatt
     1681 ccgcaaactg ctgatgcaaa aattgcagtt cccagtgtat tgagtgtgat gcgtaatgtt
     1741 tccgtgccat ttggtattaa tacgccggaa aagccttata tttcttctac ccgttggcgt
     1801 tccgtttccg atcagaagaa taaagtgtat tatttcgaat ctactttgac accaaatatg
     1861 ttttggctgg acctgaagaa aatagatttt agtccgaaag cagggattaa gaaattgtct
     1921 ctggcaaagg gagagattta tgcaggtgat gcagtgaagg atttgaaaga cagtcaatcg
     1981 tttactttcc ttttccagac tccggttatg taatttgttg gtatctgtaa atatataaaa
     2041 agagcggtgg acgggtttgt aatcatacac ttgtccatcg ctctttttta tataccgttt
     2101 gtaattagac tttttgtctg tccgctttat cgtctggcat actcctgatg aaattcaatg
     2161 actgcctcta tccctttacg gaaaatatcc agtgaaaagt tttcgtttgg tgaatggatg
     2221 gcgtctgatt ccaaaccgaa tcccatcaat acagttttga ttcccaagac ttgttcaaaa
     2281 gtagaaatga taggaatact accaccacgg cgtactgcca gcggtttctt tccgaaagca
     2341 atttcaaagc ctttttcggc agcctgataa gcagaaagcg aaatcgggca tacgtatcct
     2401 tgtcctccat gcattggagt cactttcacc tgaacagttt ccggagcaat gcttgaaata
     2461 tactctgcaa acatctgcga aatcttatga tgatcctgat gcggaactaa tcggcaggaa
     2521 actttggcat acgcctttga aggaagtacg gttttagaac cttctcccgt atatccgccc
     2581 caaatgccac atacgtcaaa agacggacga cagctgttac gttctaatgt gctgtatcct
     2641 ttttctccga aaagctcttt tacgccgatt gcttctttgt atttcttttc gtcaaaagga
     2701 atatgcgcaa tcatttcccg ttcggcttgc ggaacttctt ccacatcgtc atagaatccg
     2761 ggaacggtaa tccgtccgtc agcatccgtc accttgctga taatctggca aagtgtgttg
     2821 atgggattag ccaccgcacc gccgaaatgt ccggagtgta aatcacggtt cggcccagtc
     2881 acttctattt cccaataagc cagtccgcga agaccggttg ttaaagacgg aagttcagct
     2941 cccagcatac tcgtatctga gacaaggatg acatctgcct tcagcaactc tttgtgctct
     3001 tcgcagaaag cttccaggct gggtgagcct atttcttctt caccttcgaa gatgaatttt
     3061 acattattct tcagcaatcc gtttttgacg agatactcga acgctttcac ctggatgaat
     3121 gattgtcctt tgtcgtcatc tgctccacgc gcccagatat atccgttccg tatttccggt
     3181 tcaaatggtt ggctcttcca aagttccagc ggttcggccg gcattacatc gtaatgagca
     3241 taaaccaata cggtctttgc gtccgggtcg accatctttt gagcgaaaac aatcggattg
     3301 ccctttgagg gcatcaccaa tgcttcgtct gctccagctt caagtaacaa ctgcgcccag
     3361 cgttctgcac aagccagcat atcatcgtga tgctccggca gagcactgat actggggata
     3421 cggatgagac tgaacaggtc attcatcatt tccggttcgt gcgctattat gtatttctga
     3481 atttcgttca ttacagttgt gtcgttttat ccagtaagta ataatcaagt atagtcatgg
     3541 cggccattgc ttccacgata ggcacggcac ggggcagtac acaagcgtca tggcgtccgc
     3601 gtgctttcag ggtggtgtcg ataccatcaa tgttgacggt ttcctgttcc atcagcaacg
     3661 ttgcaatcgg tttgaatact acacggaaat aaatatcctg accattactc aatcctccct
     3721 ggatacctcc ggagtggttg gtatgtgtct cgatgcgtcc gttgttatta tagaaaacat
     3781 cgttctgttc ggaacctttc atttttagtc ctttgaatcc ttcgccgtat tcgaatgctt
     3841 tggcagcatt gatgcttaac atggcgttgc ccaaggcagc atggagtttg ccgaaaacag
     3901 gttgtccaag tccgatgggg catcccttga tgacgcaggt cagtgtgccg ccgatggtgt
     3961 caccttctcc tttcacctta tatataaggt ctgccatttc ttttgctttt tccgggtctg
     4021 gacaacgtac atcgtttgtt tctattaaat cgaggtcgta atccgagtaa gtaccctcca
     4081 gcttgatagg acctacctgt gaagtgtaag ctgtgatgct gatgcccagt tgacgaagcg
     4141 ctaacttagc caatgcaccg gctaccacgc gcgaaatcgt ttcgcgtgcg gaagaacgtc
     4201 cgccgccacg gtggtcacgg attccgtact tcactgtgta cgtgtaatca gcgtgtgaag
     4261 gacgatatac atttttcaga ttgttgtagt cattggagtg ttggttttca ttccaaacga
     4321 taaaaccaat agggcatccg gtggatttcc cttcaaaaat gcctgaaaga aactcaactt
     4381 tatcagcttc tttacgtgca gtggtaagaa tggattgtcc cggacggcgg cgattaagtt
     4441 cttgttgtac aaattcttcg tcgatgacaa ttcctgccgg aaatccgtca atcactcctc
     4501 caactccttt tccatgagac tcaccgaaac ttgtgagccg aaagatattg ccaaatgaat
     4561 taaacatagt tgtggctttt ttaaaattac tatatgcaaa tataacaaag ttttcgataa
     4621 gaaagttgtg aactcgaaat atcttcgaaa aaggaagcat attgaacctt ttttcttctt
     4681 tttagtttat aagggacgaa atttattata ataactaaac caaagacgta tgaaaaagaa
     4741 tctattgtat ttattggcat tggtctgctc tcttactttc tttgctgctt gtagcagtga
     4801 cgatgacgac agtgataaca agaataatgg gaatcctcct gaagaggaag ctgcgataac
     4861 ggctccggat gtagtcggaa cgtattgggg aaatctggat atatccatga taccggatgg
     4921 ttctgaccag gaaattgtca taggagatgg aatagagaag tttatcactc tctcgcaagt
     4981 cagcaatacg gaagtgaaga ttgaattgaa ggagtttgaa ctgtttatca accaacagat
     5041 cctgaaattt ggagatattg ttgttgataa gtgcgaagtg aagaaggggg aaggggtgtc
     5101 tacatttacc ggacagcaag accttacgtt tgagggaaat gccgctgctt tgggtacctg
     5161 tcctgtaact gttacgggaa cggtagaaga tggaaatgca gacatgacca ttaacgtgaa
     5221 agtgtctaca ttgcaacaga ctgtaaaagt gacctattcc ggagtgaaac aggtggcgga
     5281 gtctggtgga aattaattcc ttattcacca cagattacac agattaacac agattgattt
     5341 ataagtcata gactatcaat ataaatcaat ctgtgttaat ctgtgtaatc tgtggtgaga
     5401 cttaaaatgc gtacccaaaa cctatattca aatagatagg atacattgca aaagtgattg
     5461 tattaaaatc gcttttaaat atatcgttca atccccaggt gagatcagca tacacattga
     5521 ggtgcttgaa agctcgccat ccggctccca cctgtaatcc ccactggaaa tgtctcaagt
     5581 cgtccgagaa atcgtaggtt gcaattttgc cgtcggtaaa ttctactttc ggaccggtgg
     5641 gatcatcttc ccgcaaatat ccttcgtata catgacctga aaattctctt gaaagcagat
     5701 acgagaaata aggtccggct ttgatgttcc atcggttact tagtttgtag gtagccatta
     5761 gaggtatagt cagtccggcg gtatgtactt tggttttcac tccgcccgtc catactccgc
     5821 tgattctttc acctccttgt ccgagaattt ccatgttgta attttttacg gtggcttcgg
     5881 tggtcattgc tttgttttcg agccggagtc cgactatgat tccgagtttg ttctgaacgg
     5941 caatccattt ggttacttcg ccccctatgc tgatggccag tgtcgggtta tatccgtcaa
     6001 tcgaacggat ttctaccgga aggggaagcg gggctgtgcc gccaatgctg aaacctgctt
     6061 tgatttcata ttccagtccg tgaagggcgg aacggatcag cgtttcattt cggtctacct
     6121 gtgaatagcc ggggagagct attcctatac aggctaataa actgaatata tacggataga
     6181 ttttcatcat tatggttgtt ataaagttat ttaattccgt tcgtttgata atgtgcacgt
     6241 tttgtgtggg tacattgctt gagtgtatta tgaggtattg ttatggaaaa tccttcatcg
     6301 aaatcccgct aattttccga gtgatagatt aactcggcct cgtcgatcag taatgtactt
     6361 ccgattgctc cgttaaaatg atctccttcc agacttgagg taaacacaat ggctatatta
     6421 tatttcccat cccttagctt ctccttatca atgaattttc cggggagagt gatgaaagga
     6481 agtttaaagt aagtccattc gttcgtttct ttggcattat taatccgtgc tgttgaaatc
     6541 aggttcggac tggtgaatgc attcgttccg tcgagagtgg gaacagattc actggtttcg
     6601 tacatgatgg catatatgtc acagatgtcc cgtttcccgt tcacaggttt tcctccctct
     6661 gtaaactgat ctcctgcttt gtatttataa taaccagcta gataagtggg tacatgccgg
     6721 aaagggaggc cgaatttagt cgctttcagt ggattgctca ttgcgttact cacatcgaaa
     6781 gaaccgataa acagatttcc tgctgcaata ggcattcctg ctagctgacc gaagaatccg
     6841 gtactgcgtg tcactaagga gaggcatttg ccggcttttc cgtccgttat ttggaaagtg
     6901 ggataatcat cggctgtttt ggctactccg gtcatggcat aacccgcatt tccgctggcc
     6961 cattccatga cgaccttatc tctttcgcgt tctacaaata tgtagtactt ctttccgccc
     7021 agtgtatctt cgaagttata gttcgtggca agttccgtgt cgatcactga tactgtatat
     7081 gcttttttcc aaataccgtc ggcagctgtg acagtatatt cctgtggggt attgaaattt
     7141 cgttctgtgc cgctaagtgg actgatcgta gctcctggag tcaatgtaaa ttcaggtttg
     7201 agttctgaaa tatcagttcc cggaccgaca aagatagtta tggaattatt gttaataata
     7261 gggctggttg tcatggctac tcccggtagt atacaactta atatgtctgc ttctgcattg
     7321 agagcttctt cgcggatgca tgaagaggaa acaatagcta gtagcaaata gacaattacg
     7381 tgttttgctt tcatttttct atcaattctt tctgttaaag tttggtatat gggagatttt
     7441 ataacaatat gagattttat ttgttcatta tagaatgttg gaaaagaaag aatttcctat
     7501 ttttgtggaa tcaaaactta taagtctatg actgaatcag aaagaaggca aattatagaa
     7561 ttgattaaga aggaggtcat tccggctatc ggatgtacgg aacctatcgc agtagcactt
     7621 tgtgtagcta aagctgccga aacactggga gcgaaaccgg aaaagataga agtcctgtta
     7681 agtgctaata tattaaagaa tgccatggga gtcggaatac cgggaacggg tatggtcggg
     7741 cttcccatag cggttgcttt gggtgcgttg attggcaaat cagattatca gttggaggta
     7801 ttgagagatt gtacgtcgga agcggtggaa cagggaaaac tgtttatcgc agaaaaacgg
     7861 atttgtattt ctctaaaaga agatattacg gaaaagcttt atatcgaagt aatctgtaaa
     7921 acggaagata aaacggctaa agccatcatt gccggtggac atactacctt tatatatata
     7981 gccaaaaatg aacaaacgtt gctcgacaag caacagacag tcagcgagaa agaggaagag
     8041 gcttcgcccg aactaaactt gcgtaaagta tatgactttg cactgactgc tccgctggat
     8101 gaaatccgtt tcatccttga cacagcccgt ttgaacaaag ctgctgccga acaagccttt
     8161 aaaggtaact acggacattc tttagggaaa atgcttcggg gaacttatga acataaagtg
     8221 atgggggata gcgtgttttc tcatatcctc tcttatacgt cggctgcctg cgacgcccgt
     8281 atggccggtg ctatgattcc tgtaatgagt aattccggca gtggtaatca ggggatatcc
     8341 gctacacttc ctgtcgttgt ctttgcagaa gaaaacggaa aaagtgaaga agaactgatt
     8401 cgtgctttaa tgcttagcca tctcactgtt atatatatca aacaaagttt gggacgtctg
     8461 tctgctttgt gtggttgtgt ggtagctgcc acaggttcca gttgtggaat cacctggtta
     8521 atgggaggaa actacaatca ggttgccttc gctgttcaaa atatgattgc caatctgaca
     8581 ggaatgattt gtgacggcgc aaaaccgagt tgtgctttga aggtaaccac cggagtttcg
     8641 acagccgtac tgtctgccat gatggcaatg gaaaaccgtt gtgtgacttc tgtagaagga
     8701 attatagatg aagatgtaga ccaaagcatc cataacctga caagaatcgg ctcgcaagcc
     8761 atgaacgaaa cggataaaat ggtacttgac atcatgacgc acaaaggatg ctgattttaa
     8821 gtattaggta tcaagtatta agtattaggt attagccgga atgacggcat aaaaaaagta
     8881 ttaagtatta aaactccggc tatatccgca cggaattaat acttaatact ttatacttca
     8941 attaatgaca gtgtccgcct tcgcaaccgc agtcgtcgcc acagccatca ccgcagctgt
     9001 cgcatccgca accgcaacca ccttcgccac tcatcatttt caccaattcc tggatttctt
     9061 cgttggtagc aggacggctt tccagtattt caccttcgaa aatcaggtcg gcaccagcca
     9121 acgggtgatt gaggtcaact actacaacat ccggtttgat ttctactacg ctggcattta
     9181 cgcgctgacc gtcaccagtc atcaaaggta cgatgttacc ttctttaata cgttcgctgt
     9241 caaacttgcc atctatttca aaaatatttt tggggaggtc aataacgtgt tgttcgtcat
     9301 attgtccgta agccttatct gccggaatgg taaaatcaaa tttatcacct ttagaaagag
     9361 cagttatctg attttcgaaa tcttcgagtg ttgttcctaa tcctgaaatg aattgaaagg
     9421 gatgttctgc ttttgcttct tcgaacaact ctttttcacc atcttccatt gtatatagtt
     9481 tgtatgcaac ggtaatgtac ttgttttcta ctgtttccat ctgatctttt ttgtttctga
     9541 ttaataattc ccgtaaatac gggtctacaa agatacgaat tatttgcttg tactctggta
     9601 tagggagggt aaatttcaga ttattaagtg cttttgtcag aaaaagaaag tgaggtgcgc
     9661 agttagataa tagttgcaaa tttaaccttt aagtgataaa atagagaaat aatacctctc
     9721 ttttcttaca attattcgct tttaagtgat ttttttcttc gatttgtttg gatataataa
     9781 aaaagccctt acctttgcag cacgaaaata aagaaaagaa gatatgaata tgttacatac
     9841 atctattaac ctagcagtcc tgcatattat tcgcgtcgtg gtggtcccat caagagcgtg
     9901 agaaaggttt tgtgttgtat gtgttcgtac cataaaagat agaatttaga gcctttctca
     9961 cttgtgtgag gaaggctctt taattaaaag atagattgaa atgaaaaagc aattacgcag
    10021 ttcgtttagt acacaaggcc gtcggatggc gggagcccgt gcattgtggg cagccaacgg
    10081 catgaagaag aatcaaatgg gtaaacccat tatcgctatc gtcaattcgt tcacacagtt
    10141 tgtcccgggg catgtacacc tacatgaaat cggtcagctg gtgaaggcag agattgagaa
    10201 gctgggatgc ttcgctgcgg aattcaatac aatagctatc gacgacggta tagcaatggg
    10261 acatgacggt atgctttatt cgcttccttc acgtgacatc attgcagaca gcgtagaata
    10321 tatggttaat gcgcacaaag cggatgcaat ggtatgtatc agtaattgcg ataagatcac
    10381 tcccggaatg ttgatggcgg ctatgcgtct gaatattcct gccgtatttg tatcgggtgg
    10441 tccgatggaa gcgggagaat ggaatggcca gcacctggat ttgatcgatg cgatgattaa
    10501 atcggccgac gaaagtgtta gcgatcagga agtagcgaat atcgagcaaa atgcttgtcc
    10561 tacttgcgga tgctgctccg gtatgtttac cgccaactcg atgaactgcc tgaatgaagc
    10621 aatcggactg gctcttcccg gcaacggaac cattgtagcg acacacgaaa atcgtacgca
    10681 acttttcaaa gacgctgcgg aactgatcgt gaaaaatgca aaattatatt atgaagaagg
    10741 agacgaaagt gtacttcccc gtagcatcgc tacccgtcag gctttcctga acgccatgac
    10801 gctggatata gcaatggggg gatctaccaa tacggttctt cacttgttgg ccgttgctca
    10861 cgaagcagag gtagacttca agatggatga tatcgacatg ctttcccgca aggctccttg
    10921 tctctgcaag gtggctccca atacacagaa atatcatatt caagatgtaa accgtgccgg
    10981 tggtatcatt gccattatgg acgaactggc aaagggaggt ttgatagata catccgttcg
    11041 ccgggtagat ggaatgtcac tggcagaagc cattaacgaa tattcaatca ccagcccgaa
    11101 tgtaagcgaa aaagcaatta agaaatattc gagcgcagcc ggaaataaat tcaatctcgt
    11161 acttggttca caaggtatgt actataagga actggataag gaccgtgcaa acggatgtat
    11221 ccgtgacttg gaacatgctt acagcaaaga cggcggactg gccgtattga aaggcaatat
    11281 tgctcaagat ggttgtgtag taaaaacagc aggtgtagac gaaagtatct ggaagtttac
    11341 cggacctgcc aaagtatttg attcgcaaga agcagcctgt gaaggtatcc tcggaggtcg
    11401 agtcgtcagt ggtgacgtcg tcgtcatcac gcacgaaggt ccgaagggtg gtcccggtat
    11461 gcaggaaatg ctttatccta cctcttatat aaaatcccgt catctcggaa aagaatgtgc
    11521 tttgattacc gacggacgtt tcagcggtgg aacttccgga ttgagtatcg gacatatttc
    11581 tcctgaagcg gcagctggag gcaatatcgg aaaaattgta gacggagaca ttatcgaaat
    11641 cgatattccg gcccggaaga ttaacgtgcg actgacggat gaagaactgg cggcccgtcc
    11701 gatgactcct gttactcgtg accgttatgt accgaagagc ctgaaggcgt atgccagcat
    11761 ggtaagctct gccgataagg gagcagtgag aattatataa tatagttggt gatagttgat
    11821 aggtaatagt tagctgcgca gcacttagcg caatgattgt aaaccattca ttttcaactg
    11881 tcatttctca actatcattt atcatttatc aactatcaac taatatgaaa gatttaataa
    11941 caggtgcaga ggctttgatg cgctccttgg aacatcaggg agtgactacc atctttggtt
    12001 accccggtgg ttctattatg ccggtattcg atgccttgta cgatcatcaa aatatattga
    12061 atcatatctt ggttcgtcac gaacagggag ctgcccatgc cgcacagggt tatgcccgtg
    12121 tatcgggtga tgtaggtgtt tgcctggtga cgagcggtcc cggagcaacc aatacggtaa
    12181 caggcattgc ggatgcgatg atcgatagta cgcctatcgt agtgattgcc ggacaggtcg
    12241 gaacaggctt tcttgggacg gatgcttttc aggaagttga cttggtaggt atcacccagc
    12301 caatcactaa atggagttat cagattcgcc gtgcggaaga tgtagcctgg gcggtagcac
    12361 gtgcgtttta cattgctcgt agtggtcgtc cggggccggt ggtactggac tttgccaaaa
    12421 atgcgcaagt agagaaaacg aaatacgaac cgacgaaagt cgattttatc cgtagctatg
    12481 ttcctgttcc cgatacggac gaggagtctg tacaggctgc tgccgaactg attaataacg
    12541 ctgaacgtcc gcttgtattg gttggacaag gtgttgaact gggaaatgca cagagcgaat
    12601 tgcgcgagtt tatcgaaaaa gcggatatgc ctgcgggttg tacgctgctc gggctttcgg
    12661 ctttgccaac agaacatccg ttgaataaag gtatgttggg tatgcacggc aatctgggac
    12721 cgaatatcaa taccaataaa tgtgatgtgc tgattgctgt cggtatgcgt tttgacgacc
    12781 gtgtgaccgg taatttggct acttatgcca aacaggcaaa agtgattcat tttgatatcg
    12841 atcctgcgga agttaataag aatgtaaagg tagatgtagc tgtattggga gattgcaagg
    12901 aaacactggc ttctgtgacg aaacttctga aaaagcacac tcataccgaa tggattgata
    12961 gcttcaaaga atatgagaaa gtagaggagg aaaaagtaat ccgtcctgaa cttcatcctg
    13021 ccacaaactc gttgagtatg ggggaagtgg tacgtgcggt aagtgacgct actcaccatg
    13081 aagctgtttt ggtaacagat gtaggtcaaa atcagatgat atctgcacgc tactttaaat
    13141 atacgaaaga acgcagtatc attacttccg gaggacttgg aacaatgggc ttcgggcttc
    13201 ccgcagctat cggggcaact ttcggagcac cggaacgtac cgtatgcgta tttatgggag
    13261 atggcggact gcaaatgaat attcaggaac tgggtacgat tatggagcag aaggctccgg
    13321 tgaagattat ctgcctgaac aataattacc tcggaaacgt acgtcagtgg caagctatgt
    13381 ttttcaaccg tcgctattcg tttaccccga tgttgaatcc ggattatatg aaagtggcct
    13441 cggcttatga tattccttcc aaacgtgctt tcactcgtga agaactgaag gaagctattg
    13501 ctgaaatgct ggcaacggac ggtccgttcc tgctcgaagc ttgcgtggtg gaagaaggca
    13561 atgttttgcc gatgactcct ccaggtggtt cggtaaacca gatgttgctg gagtgctagg
    13621 agaagttgag agttgagaat ggagagttga gggttcgcat ttaaaaaatt agagttatga
    13681 gtgataaaac gttatataca atcattgttc attcggagaa tatagccggg ttgctgaatc
    13741 aggtaactgc tgtatttacc cgtcggcaaa taaatattga gagtctgaat gtatctgctt
    13801 cttctattaa aggtgtacat aagtatacaa taacagcctg gactgataag gacatcattg
    13861 agaaggtagt gaaacagatc gaaaagaaga tcgacgtgat tcaggcacat tatttcacag
    13921 aggatgaaat ttatttccac gagattgcat tatataaggt gtctactcct gcttttcagg
    13981 agaatccgga agcatccaag ctgatccgta gatacaatgc acgtatagtg gaagtcaatc
    14041 cggtattttc cattgtcgag aaaaatggaa tgagcgaaga tataacttcg ctctatggtg
    14101 aactgaaggc tttgaattgt gttttgcagt ttgttcgttc gggacgtgta gcgattacta
    14161 ccagctgttt tgaacgggtg aatgagtttc tcgatggacg ggaagctatg tataaccaaa
    14221 gtaaaaaaca ataagaataa tgaatgaaga aaatagaata gggacttatc agtttgtggc
    14281 agaaccgttc catgttgact tcaacggacg tctgactatg ggggtactgg gaaatcatct
    14341 g
//
