LOCUS       c00043_gnlPro..        11241 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|AGBEKEKM_45.
ACCESSION   c00043_gnlPro..
VERSION     c00043_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2025-04-29 02:19:49
            Original ID  :: gnl|Prokka|AGBEKEKM_45
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11241
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11241
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[5991:11240]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      5992..11240
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
     cand_cluster    1..11241
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /kind="single"
                     /product="TPP_fatty_acids"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..11241
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_fatty_acids"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /tool="gutsmash"
     CDS             2..79
                     /locus_tag="ctg43_1"
                     /transl_table=11
                     /translation="VSAAVNAFQKEREQPRLEAEPYTAV"
     CDS             196..669
                     /locus_tag="ctg43_2"
                     /transl_table=11
                     /translation="MKIYFANALFSHADFNYNAQLAAQIRRALPDVDMYVPQENAAINN
                     KEAYADSKMIAEADTKRLLSADLMIAILDGPVIDNGVASEIGVAYAAKIPILGLYTDSR
                     RLGAANQQKLGALQQVAENQFHYLNLYTTGLIKLNGAILTDEDSLIASIKSRA"
     CDS             complement(753..1508)
                     /locus_tag="ctg43_3"
                     /transl_table=11
                     /translation="LKGGNKLSQRESSYDIKTLENQLIKAIQQGAIQDEDGQLPAEPEL
                     MRQYQVTRYTLRQALKDLANLGYIYQAHGSGTFARPHHVEGAISLQNNVGLTEEMARQG
                     RVVKTTAIHQQVITLDQADFLPESQKLPNETTLISVTRQRTLDGQPFLVEHSYYLRSIV
                     DNIPNSALKGSLFAFIDQKPGLKVGFIDSVIECEMISGLPAKFFGIADGSPSLVVRDDS
                     YLSSGKLFAFSKIFYDFRKTKFFMLKKMH"
     CDS             complement(1634..3070)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glyco_hydro_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg43_4"
                     /sec_met_domain="Glyco_hydro_1 (E-value: 5e-131, bitscore:
                     426.8, seeds: 11, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LTAFPKGFLWGGAVAAHQFEGGWQAGGKGVSIADVMTAGDNETKR
                     RITDGVQSGENYPNHDAIDYYHRYHEDDQLFADLGLNCFRTSIAWTRIFPNGDEEQPNE
                     AGLKFYDDVFDDLLSHQIEPVITLSHFEMPYHLVKKYGGWRSRKVIDFFVKFATVVFDR
                     YKDKVKYWMTFNEINNQVGMMNEWSLFTNSGLLIKPDEDKEAVMFQAAHYEAVASALAV
                     QIGHRINPDFQIGCMVAMGPVYPATPNPNDVFKAERTMQTNYYLADVQVKGKYPAFLDR
                     YFDRHAFNLDITLEDRDVLLAGKVDYIGFSYYASHVTEASQDEPTDFITMGHNREVKNS
                     TLQRSDWGWEIDPVGLRYALNWFSDRYEVPLFIVENGFGAFDKINQDGHIQDDYRIDYL
                     RQHINQMRLAVEVDGVKLMGYTPWGIIDLVSAGTGQMEKRYGVIYVDKDDQGKGTLARS
                     KKASFDWFQKVIRSNGDDLT"
     CDS             complement(3123..4487)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTS_EIIC"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg43_5"
                     /sec_met_domain="PTS_EIIC (E-value: 8.3e-51, bitscore:
                     162.5, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDSSNNKLFKFMNNHLMGPMGKLASFRIVRGVMAAGMASIPFTIV
                     GSMFLIINVLPQSFPALVGIWKGSFDKVANLYMLANGATMGILALYFCLVFGYEYTRIQ
                     AQEEKIDINPLNGALLSMMAFFMCIPELVFKGGTATLVTEITKDNKIIDGYAIAGGVTR
                     LGTTGIFTAIIMSIIAVKLYAWFVKKNIVVSMPDTVPAGVSRSFTALIPTAAIALTVII
                     INGILMAFNTDIYKIVAIPFGFVTNLTSTWVGLMVVYFIMHALWIVGIHGATIVTSFLT
                     PIVLSNMQLNQKGANIPFAGEFNNCFVTIGGSGATLGMVIFIAFFAKSAQLGALGKASV
                     VPAFFNINEPILFGMPVVYNPYTAIPFFLAPMASMSMAYFAISMHWVKPMIAQPAWPTP
                     LGLSGFIGTAGDWRAIVLAFVCALVAFLIWFPFIKFYDGKLYKDEQAKGAAEAAA"
     CDS             complement(4510..5004)
                     /locus_tag="ctg43_6"
                     /transl_table=11
                     /translation="MSDQNKARYDKSRRELSLTSMYFNRYLLIRYVTAGFFFANLYWFF
                     LSLGTQGAMKWVPFCLTVINAVVAVEQVSKYWRRDSKLPFTKFGYVVQLISNFLSLSII
                     VAGSGTKLFPFLGQKGLSLATTVLLIGLGICFYLLVRIRLIEKNQDRYLQQINKFAQSI
                     Q"
     CDS             complement(5031..5348)
                     /locus_tag="ctg43_7"
                     /transl_table=11
                     /translation="MNEQEQLVIMQLIMAGGNAKGSSFEAIKAAKVGDFSTAEAKLKEA
                     DSFLSDAHNAQTGMLTEEAQGKKHPVSLLMVHGQDHVMNAITFRDLAGEIVDLYKKLAT
                     K"
     CDS             complement(5358..5672)
                     /locus_tag="ctg43_8"
                     /transl_table=11
                     /translation="MGKKTIMLVCAAGMSTSMLVKKMEDAATKDGIEAKIFATSASDAH
                     DKLDSEKPDVLMLGPQVRYLEGDFKKDLSIPVQVINMQDYGLMKGENVLKTALKLIDEQ
                     "
     CDS             complement(5992..7746)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg43_9"
                     /sec_met_domain="TPP_enzyme_C (E-value: 5.5e-40, bitscore:
                     126.3, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEKINAADAMIKVLEDWGIHNIYGLPGGSFDSTMNALYNRRHTI
                     NYVQVRHEEVGALAAAGEAKVTGRIGATFGSAGPGAVHLLNGLYDAQYDNVPVLALVGQ
                     VPTAAMNTNYFQEMNENPMFADVSVYNRTAMTAEQLPHVVDEAIRQAYKHNGVAVVTIP
                     KDLGWTQIDDNYVSSANLYQKPLLPDPDPDQVAAAWDILKDAKKPILYVGNGARGARDE
                     IIAFSEKTHIPIITTALAKGIVPDDYKANMGSAGRVASKPGVEVARGADTVLFLGSDFP
                     FQPYFIAPNAKYIQVDIDGSKFGRRHTVDLAVLADAKKFIKALSEKADQLPESAWYRAA
                     LANKENWREWMTSFEDDGSTPLRVEPIFKLINEMAEKDAIFQVDVGNVTINGMRYLKTN
                     DDQVFTTSGWYATMGYALPAAIGAQAEFPDRQVWSISGDGGFAMVMQDILTQVKYHMPI
                     INVVLTNESLGFIEAEQDDTQQPHSGVDLIDADYGKAAEALGAQGFEVHNLDELKAAFA
                     KAKDRKGPVVIDVKISDLRPIPVEQLVLDKQTQDPAAVDAFVKKYHAESLIPFRQLLED
                     AEKPVTNA"
     CDS             complement(8070..9236)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ACP_syn_III"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg43_10"
                     /sec_met_domain="ACP_syn_III (E-value: 1.5e-09, bitscore:
                     27.4, seeds: 136, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIGIDAIAMDTPDFYVDLVKLAQVRGDDPDKYTIGIGQDEQAVP
                     PSSQDIVTMGANAATKLLTPAIRASLGMVLVGTESGVDASKSAALFIHDLLALPEWVRA
                     VELKEACYGGTAALMMARDYIAAHPDKTVLVIAADIARYGLATAGEVTQGAGAVAMLIK
                     AEPHIMTIEDDSVYRSESIDDFWRPVYQDTAIAQGKYSTEQYLAFFQAIWSRYQTQRHH
                     TASDFAAMTFHLPYTKMGKKALKLVLPDTDEATGERLQRRFEASTRYCRRVGNIYTGSL
                     YLGLLSLLDNDTSLKAGDRIGLFSYGSGAVAEFFSGILQPDFAAQLHAANHAKMLADRQ
                     ELTVPEYEAVFSDKVPYDPEDYRSDPTYYHGQFVLTGVIGQERQYQQR"
     CDS             complement(9220..10500)
                     /locus_tag="ctg43_11"
                     /transl_table=11
                     /translation="MKFYELSPEKRRDQLVQEGWLTTQDAALLAGTHSLPEVTGARLIE
                     NAIGEFPLPLGVARNLLVNGQLHQVPIADEEPSVIAAASNGARLATANGGVRTHVAAHR
                     VVAEVVLTNLTDLVQARQTILAHQTDIQKVIAVAHPSMIQRGGGLDQLTVESLGAQFLK
                     IRLTLDPQQAMGANYANTVAEAVAAAVTSWVDGDVLVSILTNAPTELVTAEVSLEPASL
                     ATKAVSGDVIAKKIVQLSELAFVDAERAVTHNKGILNGIIGAVLATGNDTRAVAASIGA
                     FACASGRYQPLSRWYMDQGHLVGHLQLPLPMGAVGGAIGALPMAQVVRRLGGYQNLAIM
                     QQVIAALGLVQNLAAMRALAGPGIQAGHMKLQANALAIAAGATETELSMLVNALRQGSM
                     DLKHAQQYLTTIRLNKKVGQSKDENRD"
     CDS             complement(10512..11240)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: Thiolase_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: Thiolase_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg43_12"
                     /sec_met_domain="Thiolase_N (E-value: 1.8e-45, bitscore:
                     145.0, seeds: 30, tool: rule-based-clusters)"
                     /sec_met_domain="Thiolase_C (E-value: 1.7e-44, bitscore:
                     140.1, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="FSQQPMGITAENVATQFNVSRQEQDEFALRSHLRAAAAAAEGRFK
                     SQIAPVTIAARHGDVIVDRDSAIRPDTSLAKLAQLPPVFEVGGTVTAGNASGINDGAAA
                     LILMAKSKAEQLGLHYLATVTGFAEVGIDPAIMGYAPKLAIDKILQATGGSIAAIDQIE
                     LNEAFASQSVAVARDLGLKDEQFNINGGALALGHPLGASGARILISLLYDLAERNQRQG
                     IAALCVGGGIGIAMQIAMRV"
ORIGIN
        1 ggtttctgcg gctgtgaacg cgtttcaaaa agagcgtgaa cagccgcgtt tagaagccga
       61 gccatatacg gccgtttagg ttcaaggtct gtatgtgtca gattttgcga ctatgaacgc
      121 gttttatcag gccaccactt cacggcaccc cacctaaacc aacaatcccg caaactacag
      181 acgaggtctt aaaaaatgaa aatttacttt gctaacgcct tgttcagtca tgctgatttt
      241 aattacaatg cgcaactcgc tgcgcaaatt cgccgcgcct taccagatgt tgacatgtac
      301 gtgcctcaag aaaatgccgc gatcaacaac aaagaggcat acgccgattc gaaaatgatt
      361 gccgaagccg acaccaagcg gctgctgtca gctgacttga tgattgccat tctcgatggc
      421 cccgtgattg ataacggggt cgctagtgaa atcggcgttg cctatgctgc taagattcct
      481 attttgggtc tttacacgga cagtcgacgg ttaggcgccg ccaatcaaca aaaactcggt
      541 gctttgcaac aagttgcaga aaaccagttt cactatctca atctgtatac cactggttta
      601 attaaactta acggcgctat tttaacagat gaggatagct tgatcgccag tatcaaatcc
      661 cgtgcttaaa tccgattcta gtgacatgta aaaaagcttg ctaatatgtt agcaggcttt
      721 tttacatgtc actatcagcc gaattaagaa aattaatgca ttttcttaag cataaaaaat
      781 ttggttttac gaaagtcata aaagattttc gaaaacgcaa ataattttcc agaacttaga
      841 tacgaatcgt cacgaacaac taaacttgga cttccgtctg caatcccaaa gaatttggct
      901 ggtaagccag aaatcatttc acactcaatt acagagtcaa tgaatccaac tttcagacca
      961 ggcttttgat caataaaagc aaatagggac ccctttaatg cactattcgg aatgttgtcc
     1021 acaatcgatc ttaaataata cgagtgttct actaagaacg gttgaccgtc tagtgttcgt
     1081 tgccgcgtca ccgaaattaa tgtcgtctca ttcggcaatt tctggctttc aggcaaaaaa
     1141 tctgcctgat ctagcgtaat gacttgttga tgaattgccg ttgttttaac aactcgtccc
     1201 tgtctcgcca tttcttccgt caacccaacg ttattttgaa gcgatatggc cccctcaacg
     1261 tggtgtgggc gagcaaaagt gccgctacca tgtgcctgat aaatgtagcc caaattggca
     1321 agatctttta aggcttgtcg taacgtgtaa cgagtgactt gatattgacg catcaattcc
     1381 ggctcagcag gtagttgacc atcttcatct tgaatagcac cttgttgaat cgccttgatt
     1441 aattgattct cgagtgtttt aatatcatag ctactttccc gctgagacaa tttatttccg
     1501 cctttcaact ttgcttccaa gctcagtcat ttcatgttat tataccgcca tttactgttc
     1561 cggactagct ccacgtctcc agtaaaaaaa acgcccttcg aaaggcgttt ttttgactac
     1621 atgcattttc atgctaggtg agatcatccc cgttactacg aatcactttt tggaaccaat
     1681 caaaagaggc ttttttgctt cgtgcaagtg tgcctttacc ttgatcatct ttatcaacat
     1741 aaatcacgcc ataacgtttt tccatttgac cggttcccgc cgaaaccaaa tcaataatgc
     1801 cccacggtgt ataacccatc agcttgacac catcgacctc aaccgcaagt cgcatctgat
     1861 taatatgttg acgtaaataa tcgattcgat agtcgtcttg aatatggcca tcctgattga
     1921 tcttatcaaa tgccccaaaa ccgttttcga caataaataa gggtacctca tatcgatcac
     1981 taaaccagtt gagtgcataa cgcaacccga ctggatcaat ctcccaaccc cagtctgaac
     2041 gttgaagcgt cgaattctta acctctcgat tgtgtcccat ggtaataaag tctgtaggtt
     2101 catcttgtga ggcttcagtg acatgggaag catagtaaga aaatccaata taatcgactt
     2161 tcccagctaa taaaacatca cgatcttcaa gtgtgatgtc caagttaaac gcatgtcgat
     2221 caaaataacg atccaaaaat gcaggatact tgccctttac ttggacatct gccagataat
     2281 aattagtctg catcgttcgc tcagctttaa acacatcatt tggattcggt gttgcgggat
     2341 aaacaggacc catcgcaacc atacagccaa tttgaaaatc ggggttaatc cgatgcccaa
     2401 tttggactgc caaggcactt gcaacggcct cataatgagc ggcttgaaac atgactgctt
     2461 ctttatcttc atcaggcttg atcagtagcc cagaattggt gaacagagac cattcattca
     2521 tcatgccaac ctgattattg atttcgttaa aagtcatcca atatttaact ttgtctttgt
     2581 accgatcaaa cacaacagtc gcaaatttga cgaagaaatc aatcacctta cgactacgcc
     2641 aaccaccata ttttttgaca aggtgataag gcatttcaaa atgtgacaag gtaatcactg
     2701 gttcaatctg atgcgataaa agatcatcaa acacgtcatc ataaaatttc agccctgctt
     2761 cgttcggctg ttcttcatca ccattcggga aaattctagt ccaagctatg cttgtccgaa
     2821 aacagttcaa gcctaaatca gcaaagagct gatcatcttc atgatagcga tgataataat
     2881 caatagcatc atgattggga taattctcgc ctgattgaac accgtctgta attctgcgtt
     2941 tagtttcatt atcgcctgcg gtcatcacat cagcaatgct gaccccttta ccgcctgctt
     3001 gccacccacc ttcgaattga tgagcagcga ctgcgccgcc ccacaagaaa cctttaggaa
     3061 atgctgtcaa aataatcctc cttatttagt cctcgaacca tttacaattg gtctgccgct
     3121 tcttaagccg ccgcctccgc tgcacctttt gcctgctcat ctttatatag tttgccatca
     3181 tagaacttaa taaatgggaa ccaaatcagg aaggctacaa gcgcacaaac gaaagctaaa
     3241 acaattgctc gccaatcgcc tgccgtgccg atgaaccctg aaagaccaag tggtgttggc
     3301 catgccggct gtgcaatcat cggtttaacc caatgcattg aaattgcgaa gtaagccata
     3361 ctcatggatg ccatcggtgc taagaagaat ggaatcgctg tatatggatt ataaacaact
     3421 ggcataccga aaagaattgg ttcgttaatg ttgaagaaag ctggaacaac agatgccttg
     3481 cctaatgcac caagctgtgc cgattttgca aagaaggcga taaaaataac cattccaagc
     3541 gtagcgcctg atccacctat agtcacaaaa cagttattaa attctccggc aaatgggatg
     3601 tttgccccct tctgattcaa ctgcatattg gagagaacaa ttggggtaag gaacgaggtc
     3661 acaatcgttg cgccgtgaat gccaacgatc caaagcgcat gcatgataaa gtagacgacc
     3721 attagtccta cccatgtact ggtcaggtta gtaacaaaac caaacggaat agcaacaatc
     3781 ttatagatat cggtgttgaa tgccatcaaa ataccattaa tgataatgac agttaaggca
     3841 atcgcagcgg tcggaatcaa agctgtaaag gaacgtgaaa caccagctgg gacggtatcc
     3901 ggcatactga ccacaatatt ctttttaaca aaccacgcat aaagttttac tgcaataatc
     3961 gacatgatga tggccgtaaa gataccagtc gttcccagcc gagttacccc acctgcgatg
     4021 gcataaccat ctataatctt gttgtccttg gtgatttcgg tgaccaaggt cgctgtccca
     4081 cctttaaaga ctaattcagg tatacacata aaaaacgcca tcatagaaag taatgcacca
     4141 tttaaaggat taatatcaat tttttcttcc tgagcctgaa tgcgagtata ttcataacca
     4201 aaaactaaac agaaataaag tgctaaaatg cccatggtcg cgccattagc aagcatatac
     4261 aaatttgcaa ccttatcaaa agaacccttc caaataccga ctaatgccgg aaaactttgg
     4321 gggagaacat taataattaa aaacattgat ccaacgatgg taaatggaat ggatgccatt
     4381 ccggcagcca tgactccgcg aacgattctg aacgaggcaa gttttcccat tggtcccatc
     4441 aaatgattgt tcataaattt aaacaattta ttattacttg aatccatagt tttgtctcct
     4501 tgtttgagct cattgtatgc tttgagcaaa tttatttatt tgttgtaaat accgatcctg
     4561 atttttttca atcaaacgga tacgcactaa gagataaaaa catatgccta gaccaattaa
     4621 cagaacagtc gttgccagag ataaaccctt ttgtcctaaa aatggaaaca gttttgtccc
     4681 agatccagcg acaattatgg ataagctcag gaaattgctt attaactgaa ctacataacc
     4741 gaacttagta aatggtaact tgctatctct tcgccagtac ttacttactt gttcaaccgc
     4801 taccactgca tttataacgg tcaaacaaaa cggtacccat ttcatcgcgc cctgtgtgcc
     4861 caaactaaga aaaaaccaat ataaatttgc aaagaaaaaa ccggcggtca cgtaacggat
     4921 taataaatag cgattaaagt acatactagt taagcttaat tctctccgac tcttgtcata
     4981 tcttgcttta ttttggtctg acatgcgtgt cacattcctt tcgcttagac ttatttcgta
     5041 gctaactttt tatagaggtc aacgatttcc cctgctaagt ctcgaaatgt gattgcattc
     5101 ataacatgat cctgtccgtg caccatcaat aatgatactg gatgtttttt cccttgagct
     5161 tcttcggtta acatacctgt ttgtgcatta tgtgcatctg acagaaagct gtctgcctct
     5221 ttcagttttg cttctgcggt agaaaaatca ccgacttttg cagctttaat tgcctcaaaa
     5281 gaagatcctt ttgcatttcc tccggccata attagctgca tgatcactag ttgctcttgc
     5341 tcgttcatcc tgacctccta ctgctcgtca atcagcttaa gagccgtttt tagaacattt
     5401 tcgcctttca ttaagccgta atcctgcata ttgatcactt gaactgggat actaagatcc
     5461 tttttgaaat ctccctctaa ataacgcact tgtggtccaa gcatcaggac atctggtttt
     5521 tctgaatcta acttgtcatg ggcatctgaa gccgaagtag caaagatttt tgcttcaata
     5581 ccatctttgg tcgctgcatc ttccattttt ttgactaaca tactggttga catacctgct
     5641 gcacaaacta acataattgt cttcttaccc attagttttt cctcgctttc aaaatttcaa
     5701 agttattgtt caccacagaa tgacttttta atatcagcat actcgctagc ttaacgagcc
     5761 atatcagaag tcattcgaat gactattcgt tcgaacgact tttataatac caagaaatcg
     5821 ctttcttgta aacgatttct ttaatttttt aaaattttgt ctctacgcct tatcgcaaaa
     5881 gcccggcaac taataatgaa gacttaaaat agcggtaagc aaaaaaaaag ccttccagca
     5941 aggcatatta attgctggaa agctttgtaa tttatatttt aagtcaacca gttaagcatt
     6001 tgttaccggt ttctccgcat cttccagtaa ctgtcggaat ggaatcagac tttctgcatg
     6061 atatttcttc acaaaagcat ccacagcagc aggatcctga gtttgcttgt ccaaaacaag
     6121 ttgttcaacc ggaattggac gaagatcaga aatcttcaca tcaatgacaa ccggaccctt
     6181 acgatctttt gccttagcaa atgcggcttt caattcgtcc agattgtgca cttcaaatcc
     6241 ttgagcacct aacgcttcag ctgccttacc ataatcggca tcaattaaat caaccccgga
     6301 gtgcggctgt tgcgtgtcat cctgttcagc ttcaataaag cccaaactct cattcgtcaa
     6361 aacaacgttg atgattggca tatgatattt gacctgtgtc agaatatcct gcatgaccat
     6421 ggcaaatcca ccatcaccag aaattgacca aacttgccga tcagggaatt ccgcttgcgc
     6481 accaatcgct gctggcaagg cataacccat tgtcgcatac cagccagacg tcgtgaacac
     6541 ttgatcatca ttggtcttca gataacgcat cccattgatg gtaacattgc caacgtctac
     6601 ttggaaaatg gcatcttttt cggccatctc attgatcaat ttgaagattg gttcaacgcg
     6661 cagtggcgtg gagccatcat cttcaaatga agtcatccac tcgcgccaat tttccttgtt
     6721 ggccagagca gcccgatacc aagcgctttc tggcaattga tcagcctttt cgctcagtgc
     6781 cttgatgaac ttcttagcat cggccaaaac agctaagtca acggtgtgac gacggccaaa
     6841 cttgctaccg tcaatatcaa cctgaatgta tttagcattt ggtgctataa agtatggctg
     6901 gaatgggaaa tccgatccca agaacaagac ggtgtcagca ccgcgcgcaa cttcaacgcc
     6961 aggtttagaa gccacacgac cggccgagcc catgtttgcc ttataatcat caggcacgat
     7021 tcccttagcc aaggcagtcg tgatgatcgg aatatgcgtt ttttctgaga aagcgatgat
     7081 ctcgtcgcgc gcaccccgcg cgccatttcc aacatacaag attggcttct tcgcatcttt
     7141 caagatatcc caagctgcgg caacctgatc cgggtctggg tcaggcaaaa gcggcttctg
     7201 gtacagattg gctgatgata cataattgtc atcaatctgg gtccaaccta aatcctttgg
     7261 aatagtcaca acggcaaccc cgttatgctt ataagcctga cgaatcgcct cgtcaacaac
     7321 atgaggcaac tgctcagcag tcatggctgt acggttgtat acagacacat cagcaaacat
     7381 tgggttctcg ttcatttctt ggaaataatt ggtgttcatg gcagcagttg gtacttgccc
     7441 taccaatgcc aaaactggca cattatcata ctgtgcgtca tacaacccat tcagaagatg
     7501 aacagcacca ggaccggcag aaccaaacgt cgccccgatt cgacccgtta ccttagcttc
     7561 acctgcagca gccaatgcgc ctacttcttc atggcgaacc tgaacataat taatggtgtg
     7621 acggcgattg tacagcgcat tcatggtact atcaaaagaa ccgcccggta acccataaat
     7681 attatggata ccccagtctt cgagcacctt gatcattgcg tctgcggcgt ttattttttc
     7741 tgtcatgaca cttgcctcca atattattac ttacattttg taagttcttt acgattacga
     7801 gtataacaat ttattgataa caatgcaagc cctttcatcc ggcttaagta accttaacgc
     7861 ccaaattgcg accttagcgc ataaagcgct taaactagca agcgacggca ccataacagt
     7921 caaacaagtg aactaataca gcatcaccac gccataacat gcttggtaaa tctttttcac
     7981 aaattaactt aatgatgatc aggatcatgg atcaaaaaaa aggaccgtcg agggacggtc
     8041 cttttcatca tcttattagc tgtcaagcat taccgctgct gatattgacg ttcttgaccg
     8101 atcacaccgg tcaaaacaaa ctgaccatga taataagtcg gatcactacg ataatcttct
     8161 ggatcataag gcaccttatc gctgaaaaca gcttcgtatt caggaacggt taattcctga
     8221 cgatcagcca acattttagc gtgattggct gcatgcagtt gtgcggcaaa atccggttgc
     8281 aagatgccgc taaaaaattc tgccacggcc ccggagccat acgagaataa accgatccgg
     8341 tcacccgctt tcaagctagt atcattgtcc aacaacgaca gcagacccaa atacaaagaa
     8401 ccggtataaa tattgccaac tcgccggcag taccgagtgc ttgcctcaaa gcgccgttgc
     8461 agtcgctcgc cagtggcttc atctgtgtcc ggcagaacaa gctttaaagc tttcttgccc
     8521 attttggtat acggtaaatg gaatgtcatc gcagcaaaat cacttgctgt gtgatggcgt
     8581 tgggtctggt atcgtgacca aattgcttga aaaaaagcta aatattgttc cgttgaatac
     8641 tttccttgtg caattgctgt gtcttgataa accggccgcc aaaaatcgtc aatagattca
     8701 gaccgataaa ccgaatcgtc ttcaatggtc atgatgtgcg gctctgcttt gattaacatg
     8761 gcaaccgcgc ccgcaccttg tgtgacttct cctgctgttg ccaaaccgta ccgggcgata
     8821 tccgcagcaa tgactaaaac ggttttatct gggtgagcgg cgatgtagtc acgcgccatc
     8881 attagtgcgg cagtaccgcc ataacaagct tcctttaact caacggcccg cacccactca
     8941 gggagtgcca ataaatcatg aataaacaat gcagccgatt tactggcatc aacaccactt
     9001 tcagtaccaa ccaagaccat gcccaagcta gcgcgaatcg ctggcgtcaa caactttgtc
     9061 gctgcattcg cacccatcgt gacaatgtct tggctagaag gtggtaccgc ttgctcgtct
     9121 tggccaatgc caatcgtata tttgtccgga tcatcacctc gaacctgcgc gagttttact
     9181 aaatcaacgt agaaatctgg ggtgtccata gcgattgcat caatcccgat tttcatcttt
     9241 tgattggcct actttcttgt ttaaacgaat ggttgttaaa tattgttgcg catgttttaa
     9301 atccatacta ccttgacgaa gtgcgttcac aagcatcgac aattctgttt ctgttgcccc
     9361 ggcagcaatg gcgagggcat tagcttgcaa cttcatgtga ccagcttgaa tccccggtcc
     9421 agccaatgct cgcatcgcag caagattttg caccaacccg agggcggcaa taacttgctg
     9481 catgatagct aaattctgat acccaccgag ccgtcggaca acctgcgcca ttggtaaagc
     9541 accgatcgcc ccgccaaccg cccccatcgg caagggcagc tgtaagtgac caactaaatg
     9601 gccctgatcc atataccagc gcgataaagg ctgatacctg ccagacgcac atgcaaatgc
     9661 accgatactt gctgcgacag cgcgggtatc attgccagta gccaatacag caccaataat
     9721 accgttaaga atgcccttgt tgtgggtcac tgcccgctca gcatcgacaa aggctaactc
     9781 gctaagctga acaattttct tagcaatcac atctccagaa acagctttcg tcgctaaaga
     9841 agccggctca agtgaaacct cagccgtcac gagttctgtt ggcgcgttgg ttaaaatact
     9901 gacaagcaca tcaccgtcta cccagcttgt caccgccgct gcgaccgctt cggcaactgt
     9961 attcgcataa ttggccccca ttgcctgttg cggatcgagc gttaaacgga ttttcaagaa
    10021 ctgtgctcct agtgattcga ccgttaactg atcaagacca ccgccacgtt gaatcatcga
    10081 aggatgcgca accgcaatga ctttctgaat atcagtctga tgagccaaaa tcgtttgcct
    10141 tgcttgcact aagtccgtca agttagtcag gactacttca gcgaccactc gatgcgccgc
    10201 tacatgggtc ctaacgcccc cgtttgcagt cgcaagcctg gccccattac tggcagctgc
    10261 aatcacagaa ggttcctcat ccgctatagg cacttgatgt agctgtccat tgaccaacaa
    10321 attgcgagca acgcctaggg gtaaaggaaa ctcgccgatg gcattttcga tcagacgcgc
    10381 tcctgtgact tcaggcaagc tatgcgtacc agctaacaac gcagcatcct gtgttgttaa
    10441 ccacccttct tgaaccaatt gatcacggcg tttttccgga gacaactcgt aaaatttcat
    10501 cacgatctcc ctcagacacg catcgcgatt tgcatggcga taccgatgcc accgccaacg
    10561 cacaatgcgg caatgccttg gcgttgatta cgttcagcca gatcgtacaa taatgagatt
    10621 aaaattcggg cacctgaagc tcccaatgga tgacccaacg ctaaggcgcc accattgata
    10681 ttgaattgtt catcctttaa accaaggtca cgagccacag caacgctttg tgaggcaaat
    10741 gcttcattca attcaatttg atcaattgcc gcgatagagc cgccggttgc ctgcagtatt
    10801 ttatcgatcg ccagttttgg cgcatacccc ataattgccg gatcaatacc cacctcggca
    10861 aaaccagtga ccgtcgctaa ataatggagc cccagttgtt cggctttcga ttttgccatc
    10921 aggatcaagg cggctgcgcc atcattaatg ccgcttgcgt tacctgctgt aacagtaccg
    10981 ccgacttcaa aaacaggcgg taattgggct aatttagcca atgacgtatc gggccgaatg
    11041 gctgaatcac gatctacgat gacatccccg tgacgggcag caatcgtcac tggggcgatc
    11101 tgactcttaa accgaccctc agctgcggcg gccgcggcgc gtaaatgcga acggagagca
    11161 aactcatctt gctcctgacg actgacgtta aattgtgtcg ccacattttc cgccgtgatt
    11221 cccattggct gctgactgaa g
//
