LOCUS       gnlProkkaAMCMEHBA_53   10446 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|AMCMEHBA_53.
ACCESSION   gnlProkkaAMCMEHBA_53
VERSION     gnlProkkaAMCMEHBA_53
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 01:56:31
            Original ID  :: gnl|Prokka|AMCMEHBA_53
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 4972
            Orig. end    :: 15418
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10446
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[5000:5446]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5446
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10446
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10446
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     CDS             10..1386
                     /locus_tag="ctg53_5"
                     /transl_table=11
                     /translation="MSKYRTETDTLGPVEIPANALWGPQTERSRHNFQAGPLMPMPVIR
                     ALLQLKKAAARANVAADVLPAPKGQLITRAVDALLALPDEKLQKDFPLHVYQTGSGTQT
                     NMNVNEVISHQAAKLNPDLPILPNDDVNHSQSSNDAFPTVMNITAAIAVNQLLHAVNQL
                     CSVLYSKAVTYARVVKIGRTHLQDATPLTFGQEISGWVAMMEHDQIALKQLQPNLFYLA
                     IGGTAVGTGLNADPNFGKIVAGRLSDVYQLPLSAKTNKFAALAAHSEISVVHGAIKTLA
                     ADLLKIANDIRFLASGPRAGYGELRIPANEPGSSIMPGKVNPTQAEALTMAAVRVMGND
                     TTITVAASQGNFELNVYKPVIISTFLESADLLTKTVTSFTEKLAAGLTIHAPHMRALVD
                     HSLMLVTALAPHIGYEKSAAIAQLAEQENLDLKAAAIKSGDVTAAQFDKWVDPLKMTRA
                     "
     CDS             complement(1648..2811)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1217:NADH:flavin oxidoreductase/NADH oxidase (Score:
                     291.3; E-value: 1.5e-88)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg53_6"
                     /transl_table=11
                     /translation="MSGYHFLKPFTFKHQTITLKNRIVIPPMTTRLSFEDGTVTRDEIR
                     YYQQRAGGVGMFITGTANVNALGKGFEGELSVADDRFIPGLSKLAAAMKTGGTKAILQI
                     FSAGRMSNSKILRGEQPVSASAVAAPRAGYETPRALTSAEIEATIHDFGQAVRRAILAG
                     FDGIELHGANTYLIQQFYSPNSNRRTDEWGGDRDKRMRFPLAVVHEAEKVIATIADRPF
                     LLGYRISPEELEQPGITLDDTLALIDTLKQTKIDYLHVSQSDVWRTSLRNPEDTAIMNE
                     QIRDHVAGAFPVIVVGGIKTPADAEKAAESFDLVAIGHEMIREPHWVQKVLDHDEKAIR
                     YQIAPADLEELGIAPTFLDFIESISGGAKGVPLTTAQSVTSSNVTQD"
     CDS             complement(2837..3571)
                     /NRPS_PKS="Domain: PKS_KR (6-169). E-value: 4.9e-12. Score:
                     38.0. Matches aSDomain: nrpspksdomains_ctg53_7_PKS_KR.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     192.7; E-value: 1.3e-58)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg53_7"
                     /sec_met_domain="adh_short (E-value: 3.5e-35, bitscore:
                     112.2, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVKDKVVVITGASSGIGAATVQVLAEAGAKLVIGARRTERLAEL
                     AASFTNGQVLYQQTDVTDQQQVKALIDLALDKFGHVDVLYNNAGLMPLSEMAELKVNEW
                     ERMIDVNIKGVLYGIAAVLPPMIAQHSGQIITTDSVAGHIVHPGTAVYSGTKWAIQAIM
                     DGLRQEQAANHIKTTMISPGAVNTELFSTITDPKRREAVEADEKNNGLSASDVAKAVLY
                     AIDQPANVAINEVLLRPVTQER"
     aSDomain        complement(3065..3553)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg53_7_PKS_KR.1"
                     /evalue="4.90E-12"
                     /label="ctg53_7_PKS_KR.1"
                     /locus_tag="ctg53_7"
                     /protein_end="169"
                     /protein_start="6"
                     /score="38.0"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VVVITGASSGIGAATVQVLAEAGAKLVIGARRTERLAELAASFTN
                     GQVLYQQTDVTDQQQVKALIDLALDKFGHVDVLYNNAGLMPLSEMAELKVNEWERMIDV
                     NIKGVLYGIAAVLPPMIAQHSGQIITTDSVAGHIVHPGTAVYSGTKWAIQAIMDGLRQE
                     "
     CDS_motif       complement(3470..3550)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg53_7_0001"
                     /evalue="1.90E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg53_7"
                     /protein_end="34"
                     /protein_start="7"
                     /score="14.1"
                     /tool="antismash"
                     /translation="VVITGASSGIGAATVQVLAEAGAKLVI"
     CDS             3776..4729
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039:aldo/keto reductase family oxidoreductase (Score:
                     223.7; E-value: 5.1e-68)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg53_8"
                     /transl_table=11
                     /translation="MKQVRLGGSNWQASSVALGIMRMNVLAPDKAANVLDSAYNDGINF
                     IDSADIYGQGKSEEVFGEALKQASVSRDQLFIQSKVGIVVDPKRSHGSLVFGKRYDFSK
                     DHLLSAVDHILKRLQVDYLDSVLLHRPDPLMEVDDVAAAFDALEQSGKVRHFGVSNFNP
                     EQIALLESGIRQPLLIDQVQFSVAHTGMVNAGMHTNMADAASVDHDGSLLPYLQRKHMT
                     LQAWSPFQYGMFEGTFIDSPKFKALNDELQKVADHYHTNKNAIAVAWLLRHPVGVQVIL
                     GSMNPEHIKESAEGADITLTRQEWYDIYFAAGNDLP"
     CDS             5001..5234
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg53_9"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 2.5e-15,
                     bitscore: 47.3, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYNYRQLDDFQLSGVSGGKKKFDCAATFVTGITAGIGSGTITGL
                     AGGPFGIIGGAVVGGNLGAVGSAIKCLGDGMQ"
     CDS             5231..5446
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg53_10"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 1.1e-09,
                     bitscore: 29.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISKEVGITLKQHDLVLIQGGAKRRNKPSGCIVSTIGGAVAGAAG
                     LNPFTTVAGAAIGLSLCLSTNYIHPA"
     CDS             5582..5848
                     /locus_tag="ctg53_11"
                     /transl_table=11
                     /translation="MDKIISIIIVILILLATIAFYLAPFVGGLWQGAARSKVIAKILLL
                     NRDLKLSSKGLSRLINPQNPYIVLTTLDGRLDFTFISMSNLKS"
     CDS             6160..6756
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Mac"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1156:Chloramphenicol acetyltransferase (Score: 107.6;
                     E-value: 1.1e-32)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg53_12"
                     /sec_met_domain="Mac (E-value: 1e-10, bitscore: 32.4,
                     seeds: 568, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNLEEKFAFMATGKPYDDMDPLLLAVRDEATAKTDALNNEHDPAK
                     RNALFRKLVGQTGFKPFVNPNFHCEFGRNIRVGDHFYANYDCTILDGAPVTIGNHVLFG
                     PKVGLYTSNHLFDPLERQLGGCIAKPIVVGDGCWLAANVTVLPGVTIGAGTIIGAGSVV
                     THDIPARVIAAGNPCEVLREITAADKTGFAGHDMI"
     CDS             6875..7210
                     /locus_tag="ctg53_13"
                     /transl_table=11
                     /translation="MTDKRETLMSMLSRAYANPTIKAEPALRALIETNAKKVDEGDDDK
                     AYVTAVTQLSHDISKYYLIHHAVPEELVAVFNYIKKDVPAADIDAAHYRAQALAAGLIA
                     IPIVWGH"
     CDS             7531..7716
                     /locus_tag="ctg53_14"
                     /transl_table=11
                     /translation="MTLNKAIHYLLLIGISGVFLFTLAAAIGWVNQGDFALPLLLLAAG
                     LTLLREADAGNEKARH"
     CDS             7968..8300
                     /locus_tag="ctg53_15"
                     /transl_table=11
                     /translation="MNMIQRNKVYFIMTGLNESFQQTATVSVMNTDAQEVIDDALHILE
                     KENMLQNRAIDYALARLYSRFVRLIGLQGMKLSPEADQWWQQLKDFMENDIHEELSQVG
                     GPHFIT"
     CDS             8275..8574
                     /locus_tag="ctg53_16"
                     /transl_table=11
                     /translation="MADRTSLLDRFVPNIGTRKCEVGSRVLRCLSCDLPLDLDWLGKGH
                     DEMHRIKNDDLQQMIDGMTWRKFLTMLILGLIAIDAWSHTDQIIAGFLKGWQGM"
     CDS             8859..9659
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg53_17"
                     /sec_met_domain="Abi (E-value: 4.2e-13, bitscore: 40.2,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKKRQQLFTPGLRVLYIFILDELIEAFVFTPFLNFLQLNFWADI
                     VLYKVLSLVAILGLNLLLLRQKIIFRTSFGWPSWQKFVFWDIVGCLVAWQIFTNRNFLD
                     ILQASVIGTIAAVPEEYLYRGVIFGGLLRAFYLANRGGTRRNFIYCMLLSSLAFSLAHL
                     SNLPSQGAVATVGQMIQVSGMGMLLAALYVRYGTLLMPIFVHFMIDFLVTLIHGPYPSK
                     LNGVSDETTLITVSLIWDTIYLVISMWVLWHCHDKEGFMARLSK"
     CDS             10009..10194
                     /locus_tag="ctg53_18"
                     /transl_table=11
                     /translation="MSFRKVSSFIVGGGFLFAIVWLILSDLDLLPHISFIDRYYLIFLV
                     IFIVVCEKSQKNKPTN"
ORIGIN
        1 gaggtaaaca tgagcaaata tcgaacagaa acggacacat taggaccagt tgaaattccg
       61 gcaaacgctt tgtggggacc gcaaacagag cgcagccgcc ataattttca ggctggtcca
      121 ttgatgccga tgccagtgat tagggccttg ctgcaactca aaaaagcggc agcgcgagca
      181 aatgtggccg ctgatgtttt accggcacca aaaggccaat taatcacgcg agcagtcgat
      241 gccttgttgg ccttgccaga cgaaaaactg caaaaagatt ttccactgca tgtctatcaa
      301 accgggtctg gcacacaaac aaatatgaat gtgaacgaag tcattagcca ccaagctgca
      361 aaactcaacc ccgacttgcc gatcttaccg aatgatgatg tgaatcacag tcaaagctcc
      421 aatgatgctt ttccaactgt gatgaatatt acggcggcta ttgcagtgaa tcagttgttg
      481 cacgctgtca accaactgtg cagtgtttta tattcaaaag ccgtcactta cgctcgtgtt
      541 gttaaaatcg gtcgaactca tttacaggat gcaacgccgc taacgtttgg ccaagaaatc
      601 agcggatggg tggccatgat ggagcatgat cagattgctt taaagcagct tcagcccaat
      661 cttttttact tagccattgg cggaacagca gtcggaacgg ggcttaacgc tgaccctaat
      721 tttggcaaga ttgtggcggg ccgattgagc gatgtttatc aattaccact ttcggcgaaa
      781 accaataagt ttgctgcttt agcggcacac tcagaaatta gcgttgttca tggtgccatt
      841 aaaacgctag cggcggatct gcttaaaatc gccaatgaca ttcgcttcct tgccagtggt
      901 ccacgtgctg gatacggcga gttgcgcatt ccggccaatg agcctggtag ttccatcatg
      961 ccgggcaaag tgaatcccac acaggccgaa gcgctaacca tggccgctgt tcgagtcatg
     1021 ggcaacgata cgacgatcac ggtggccgcg tcacaaggca attttgaatt gaacgtctac
     1081 aagccggtta tcatcagtac ctttttagag tcagctgatc tactaaccaa aacagtcacg
     1141 agtttcactg aaaaattagc tgccggcttg accatccacg caccgcatat gagagcactc
     1201 gttgatcatt cgctcatgct ggtcaccgcc ctcgcacccc acatcggcta cgaaaaaagt
     1261 gccgccatcg cgcaattggc tgagcaagaa aacctcgatt taaaagcagc cgccatcaaa
     1321 agcggcgacg tcacagcagc gcagtttgat aaatgggtcg acccgttaaa aatgacaaga
     1381 gcgtgagctg gcgtggttag ctcggcgtag cgaagtggca gtgacacaga tggtctgggc
     1441 tttggaccat ctgtgtcact gtccttcgca tagccgagct gcgccagcga acgcgtttaa
     1501 gtcagagcgt gagcaggtga tgatcacacc ttgatttaaa acttataaat cactggtagc
     1561 ttcaggcacc agcgcgtaag ttgaagacgg caagaaaaaa gccgagcttt ttacagctcg
     1621 actcgcacga tgatttgaaa tgctagatta atcttgagtc acgttgcttg atgtcacaga
     1681 ctgcgcagtt gttaacggga caccttttgc cccaccggaa atactttcga taaaatcgag
     1741 gaaggtcggc gcaatgccaa gttcttcaag atcagcaggg gcgatctggt aacggatcgc
     1801 cttttcgtca tggtctaaga ccttctgaac ccagtgcggc tcgcgaatca tttcgtgacc
     1861 aatcgcgacc aaatcaaagg attctgccgc tttctcagca tcggcggggg ttttaatgcc
     1921 accgaccaca atcactggaa aagcaccggc gacatggtca cgaatttgtt cattcatgat
     1981 ggctgtgtcc tcggggttgc gcaatgaggt tcgccaaacg tcactttggg agacgtgcaa
     2041 gtaatcaatc ttggtttgtt tcaaagtgtc gattaaggcc aaggtatcat ccaaggtaat
     2101 gccaggctgt tccaactctt ccggcgaaat gcggtagcct aacaaaaatg gccggtcagc
     2161 aattgtggca atcacttttt ctgcttcatg aacgactgcc aacggaaaac gcatccgctt
     2221 atcgcggtca ccgccccatt catcggttcg gcgattagag tttggcgaat agaattgctg
     2281 tatcagatag gtgttggcac catgcagttc gatgccatca aaaccagcaa ggatggcgcg
     2341 gcgcacagcc tgaccaaaat cgtgaatagt ggcctcgatt tctgccgatg tcaatgcgcg
     2401 cggtgtttcg taacccgccc gtggcgcagc aaccgcactg gcactgactg gctgctcacc
     2461 gcgcagaatc ttgctattgc tcatgcggcc agcgctgaag atttgcaaaa tagccttggt
     2521 gccgcctgtt ttcatcgcag cggcgagttt gctcaaaccg gggatgaatc gatcatcagc
     2581 gacacttagc tcaccttcga atcctttgcc aagcgcattg acgttggcgg taccggtaat
     2641 aaacatgccg acgccaccgg cccgttgctg gtaatacctg atttcgtccc gcgtcacagt
     2701 gccgtcttca aacgacaggc gcgttgtcat cggcggaatg acaatgcgat ttttcaacgt
     2761 gatggtttgg tgcttgaagg tgaacggttt taaaaaatga taacccgaca tgcaatcaca
     2821 ctcctttaga cgaaaattaa cgttcttgcg tgactggccg taagagcact tcattgatgg
     2881 caacattggc cggttgatca atggcataca aaactgcctt ggcaacatcc gaggcgctga
     2941 ggccattgtt tttttcatcg gcttcaacag cttcacggcg cttaggatcg gtaattgtgc
     3001 tgaaaagctc agtattcacg gcaccgggcg agatcatggt cgttttaata tgattagccg
     3061 cttgttcttg tcgcaggccg tccatgatcg cctggatagc ccacttggta ccggagtaaa
     3121 cggcggttcc agggtgaaca atgtgaccgg caactgagtc tgttgtgata atttggccac
     3181 tgtgttgggc aatcataggc ggtaaaaccg cggcgatccc atacaagacg cctttaatgt
     3241 tgacgtcaat catacgttcc cattcgttga ctttgagttc ggccatttca gaaagtggca
     3301 tcaggccagc gttgttatac aaaacatcca catgaccaaa cttatccaac gccaaatcaa
     3361 tcagcgcttt cacttgctgc tggtcggtca catcggtttg ttgatacagc acctgaccgt
     3421 tcgtaaagct ggccgccaat tcagccaacc gttctgtgcg ccgcgcaccg atgactagtt
     3481 ttgcaccagc ctcggccaac acttgtaccg ttgccgcgcc aatcccgctc gatgcacctg
     3541 tgattacaac cactttatct ttaactgtca aaatcacggc ctcctttatg ggcttatcct
     3601 gctaagaaaa aataagtaac agacacagct taacctaccg cgcagctcag caccatgcaa
     3661 gctgttttat tgaaattcta atattggctt gacctcaagt ggactttagg ggctacactt
     3721 aacttgtcgt cagtaacata atttgaaatg acgtatcgaa gggagttttg tgtttatgaa
     3781 acaagttcga ttaggcggat ccaattggca ggcgtcaagt gtggccttgg gcatcatgcg
     3841 gatgaatgtg ctggcccccg acaaagcggc caatgtgctg gatagtgcgt acaatgacgg
     3901 catcaacttt atcgactcgg ccgacattta tggccaaggc aaatccgaag aagtttttgg
     3961 tgaagccttg aagcaagcca gcgtttcccg cgatcagtta ttcattcaat cgaaagtcgg
     4021 gatcgtcgtt gatccaaaac gctctcatgg cagtttggta ttcggcaaac ggtacgactt
     4081 ttcaaaagat cacttactgt cagcggttga tcacattttg aaacggttgc aggttgatta
     4141 ccttgattcg gtcttgctgc accggccaga tccgttaatg gaagtcgatg acgttgcggc
     4201 ggcctttgat gcattggaac aaagcggcaa ggttcggcat tttggtgtct ccaactttaa
     4261 ccctgaacaa attgcgttgc ttgaaagcgg cattcggcag cctttgctga tcgaccaagt
     4321 tcagttctcc gttgcgcaca ctggtatggt caatgcgggg atgcacacca acatggccga
     4381 cgcggcttct gtcgatcatg acggcagcct gctaccatac ttgcaacgca aacacatgac
     4441 cttacaagcc tggtcgccat tccaatacgg catgtttgaa ggtaccttca tcgatagccc
     4501 gaaatttaag gcgttgaatg atgaactgca gaaagtcgct gaccactacc ataccaataa
     4561 aaatgcaatc gcagtcgctt ggctattacg ccatccagtc ggtgtgcaag tgattctcgg
     4621 ctctatgaat cctgaacata tcaaggaaag tgcggaaggc gcggacatca cgttgacccg
     4681 acaggaatgg tatgacattt actttgcggc ggggaatgac ttgccgtaag ttgatgatat
     4741 gaaaaaattg tctcaaattg ctgagacgat tttttttgca aaaaattgaa gtttttacca
     4801 agcaaggaga tttaaacgtt aagaattttt gacttttaaa gcgcaactga acaataaaag
     4861 tgtaaagacg acgttaaact ggaaatttcc tacctttaaa aaattttggc attttacaca
     4921 aataattaat gtatgttaaa gacagtaaaa tcgaccttac acaaaataac ttgttgcttt
     4981 ttgaagaaaa aaggaaaatt atgtcttata attatcgcca gctcgacgat tttcagttgt
     5041 caggggtttc aggtgggaaa aagaaatttg attgtgctgc tacatttgtt actggcatca
     5101 cggctggtat tggatcagga acgattactg gcctagctgg tggtcctttt gggataatcg
     5161 gcggcgccgt agttggtgga aacttaggag cggttgggtc agctattaaa tgcttaggag
     5221 atgggatgca atgataagta aagaagtggg cattacttta aaacagcatg atttggtctt
     5281 aatccaagga ggagccaagc gacgcaataa acctagtggg tgtattgtgt ccacgatcgg
     5341 gggagcggta gcaggggcag ctggattaaa tccatttaca actgttgcag gcgctgcaat
     5401 aggattatcc ttgtgtctca gcactaatta cattcaccca gcctaatatt ggacaaagac
     5461 ggttagctcc tatcgcaact gttcaatata actaacacct tggtagtgct cactttttct
     5521 tgtcttagtc aaagatcgat ttcaaattag tctatttgtg caaaaggaag aggaaataca
     5581 aatggataag ataataagta tcatcatagt tatcttgatt ttactggcga cgatcgcttt
     5641 ttatctagca ccatttgttg gaggactttg gcaaggggca gcaagaagca aagtcattgc
     5701 caagatactt ttgttaaatc gggatttgaa actatctagt aaggggctga gtaggttaat
     5761 caatccccag aacccttata tagttctcac tactctagat ggaagacttg actttacatt
     5821 tatctctatg tcaaatttaa aaagctaaaa tctgagttaa tgtcacttga gattaagtct
     5881 atggattaag ctgataaagt ccgaggaagt agctgaaatt tcctaacgcc agaattttgt
     5941 gacgatgaag actgtaactg tatgtttctg tttgtaacaa aacaggcgtg gttctgtgtg
     6001 cagaagcgat gtcattgttt tcaagccacc atttcttcaa gaagtggtgg ctttttgtag
     6061 acttcatgcg taccgataag cacaccttaa catattggca attatcaacg cagtgcgcaa
     6121 atgtctggta aacttgagcc aataaagagg ggtggcgcaa tgaatctaga agaaaaattt
     6181 gctttcatgg caactggtaa gccatacgac gacatggatc ctttgttact ggctgtgcgg
     6241 gatgaagcaa ctgccaaaac tgatgcactt aacaatgaac acgatccagc caaacgcaat
     6301 gccttgttta ggaaattggt aggccaaact ggcttcaaac cgtttgtgaa cccaaacttt
     6361 cactgtgaat ttggtcggaa tatccgcgta ggcgatcatt tttatgccaa ttatgactgt
     6421 accattttgg acggggcgcc ggtgaccatt ggcaatcacg ttttgtttgg cccgaaagtc
     6481 ggtttgtaca ccagcaacca tctttttgat ccgcttgaac gacaacttgg tggctgtatt
     6541 gctaaaccga ttgtagtcgg ggatggctgt tggctcgctg ccaatgtgac ggtactacca
     6601 ggcgtcacga ttggtgcggg gacgattatc ggagcaggta gtgttgtcac ccacgacatc
     6661 ccagcgcgcg tgattgcggc gggtaatcct tgcgaagtgc tccgcgagat cacggctgct
     6721 gataaaacag ggtttgcagg gcatgacatg atctaaacgc caaatcgata cttgaaatta
     6781 gcaattgaca agcgcatcct aacaatattc acaaagacta aggtgctccg agtgagcatg
     6841 aattgccaag ttaatcatcg aaaggaagtg caggatgaca gataaacgtg aaactttaat
     6901 gtcgatgcta agcagggcat acgctaaccc aacgatcaaa gcagagccgg cattacgggc
     6961 gcttatcgaa accaacgcca aaaaggttga tgaaggtgat gacgataagg cttatgtgac
     7021 ggctgtcact cagttgtccc acgacatttc caaatactat ctgattcatc acgccgtacc
     7081 agaagagctg gtggccgtct tcaattacat caaaaaagat gtacctgctg ccgatattga
     7141 tgcagcacat tatcgtgcac aagcactggc agccggctta atcgccattc ctattgtttg
     7201 gggacactag ccgaggtggg gctgtgaatt ttaaacggtg aggctagagt tgatgatcaa
     7261 tcagttatca tttgccaaaa aacgtcgcag actaagatct gcggctattt ttttgccatg
     7321 aaacttgttg acaccagtta agaaaaaccg agtagcagat cgataaagag aaaatttggt
     7381 cgatatttga caaaaaagcg acgttaatcg ggcaaaaccc tacgtttaaa aaaagtttgc
     7441 gctgttgtgt gaactatcca gtatagtgtg cgtaaaagca tccgcgagaa aaagtcgaag
     7501 ttcatctgga cggggggata caagttggcg atgacgttga ataaagcaat tcattatctt
     7561 ttactgatag gcatcagtgg tgtctttctt tttacgctgg ctgccgccat aggctgggtc
     7621 aaccaaggtg actttgcgct gccactactg cttttggcgg caggactcac gttgttgcgg
     7681 gaagctgatg ctggaaatga aaaagcgagg cattgaattg ggtctgctta gaaggcagaa
     7741 aaacgtgagg ccgaatttct gtacacaagg acaaactgat tttaaaatgt aatcggttac
     7801 gatgactcat atctaaaaga gttcaaatac aagacggtat caagatccat cagtcgggct
     7861 ataaagccat tgttttccgg tgctttgcct aaaagctata gcatcgatac ttttcaaaca
     7921 tttctataga aaaattgtca cgacatcaaa ggaaatggtg acatatcatg aacatgattc
     7981 agcgaaataa agtctatttt attatgacag ggctcaacga aagctttcag cagactgcaa
     8041 ccgtcagtgt catgaatacc gatgcacaag aggtcattga tgatgcgctc cacattttgg
     8101 aaaaagaaaa tatgcttcaa aatagagcca ttgactacgc attagctcgc ctgtattctc
     8161 gctttgttcg cttaattggg ttgcagggga tgaaattatc gccggaagct gatcaatggt
     8221 ggcaacaact gaaagatttc atggagaatg atattcatga agagctgagt caggttggcg
     8281 gaccgcactt cattacttga tcggtttgtt cccaatattg gcacacgcaa atgcgaagtc
     8341 ggaagtcgag tgttacgctg tttatcctgt gacttaccac ttgatttaga ctggttgggg
     8401 aaggggcacg atgagatgca tcgaataaag aatgatgatt tgcaacaaat gattgacggg
     8461 atgacctggc gtaaatttct gacaatgctg attttaggat tgattgcgat agatgcttgg
     8521 tcacacactg accaaattat tgcggggttt ttaaagggat ggcagggcat gtaggtgttt
     8581 gtgaccggtg aagaattgcg ccaattgcaa gctccgcgac tttttcaaca ctgcagcgtc
     8641 acttcttctt ggcttagcgt agcgtcgttt gccgagtgaa gtggcttttt ttgtcaataa
     8701 atgaccgcta gcgaattttt gacggatgat cgtcaacgtt aaatggcgaa aacacgacgt
     8761 ttaaaattag ttgactaaac gccattcatt aattggtata ttgttcatag caatgtcgta
     8821 aaaatgccgg ctttgtaaac ttgaatgaag gtgacggaat gaaaaagaaa cggcaacagt
     8881 tgttcacgcc tggattacgt gttttataca tttttatctt ggatgaactt atagaagcat
     8941 ttgtgttcac cccatttttg aattttctac agctgaattt ttgggcagac attgtgctct
     9001 ataaggtgct tagtttagtt gccattcttg gactcaatct gttgctgtta agacaaaaga
     9061 ttatctttag gacgtcattt ggctggccaa gctggcagaa atttgtgttc tgggatattg
     9121 tgggctgcct tgtggcttgg caaatcttta ccaaccgaaa cttcttagat attttacaag
     9181 caagtgtcat tggtaccatc gccgctgttc ctgaagagta cctatatcgc ggagttattt
     9241 tcggtggctt gctccgcgcc ttttaccttg ctaaccgtgg tggtaccagg cgcaacttta
     9301 tctattgcat gttactaagc agtctggcgt tttcgcttgc acacttgagt aatctgccaa
     9361 gccaaggtgc tgttgcaact gtgggtcaga tgattcaagt cagcgggatg ggcatgctgc
     9421 tggctgctct ctacgttcgt tatggcacat tactgatgcc gatctttgtt catttcatga
     9481 tcgacttctt ggtaacgctg attcacggcc cttatcccag caaattaaat ggggtaagtg
     9541 acgaaacgac gctcataact gtttcgttga tctgggatac gatttacttg gtcatttcca
     9601 tgtgggtcct atggcactgt catgacaaag aagggttcat ggcaaggttg tcaaaatgag
     9661 gtttatgtcg gaacagcacg actgaggaac ttagttaacc gaaaagggga ttcgaatggc
     9721 aaaagcattc aagatctgcc tgattattgg aggcattctc ctatcggacc tatacagtga
     9781 catcagcaat cggctggact aatcatggtg attttgtact accattatta cttctatgta
     9841 cattggcgcc atgtctggac agcctgtgtg catctgatga aaagaagaag tgaatcagat
     9901 acagatcata acgtctgaat gcatttaatc tcccaatcgg tgaatgaact gtttgcgtta
     9961 ttgccaaaaa cgaaccttgt tgaagaatga tagagagtgg gtctgtttat gagttttaga
    10021 aaagtgagca gctttattgt tggtggcggc tttttatttg ctatagtttg gctgatttta
    10081 agtgatctag atttattacc tcacatttca tttattgatc gctactattt gatctttctc
    10141 gttattttta ttgtggtgtg tgaaaaaagt caaaaaaaca agcctacaaa ttaagcgatg
    10201 acgaggcgac gcttagtttg taggcttatt ttgattcatc acgattccaa gtgttgtggt
    10261 gccagtccgc atgctttgac agaccaaata gtttctttaa taaatcaaaa ccgttagcaa
    10321 cgattgcgag gtcaatcacg atatagacaa agatacttga atcatcggga acaagaaaga
    10381 gcaacgccac taagcaacaa ttaatgatcc acattgacag tggttgtttc aactgcttgt
    10441 atgcat
//
