LOCUS       c00057_gnlPro..        16473 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|AMCMEHBA_57.
ACCESSION   c00057_gnlPro..
VERSION     c00057_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2025-04-30 02:34:27
            Original ID  :: gnl|Prokka|AMCMEHBA_57
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16473
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16473
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[5041:7950]"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      5042..7950
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
     cand_cluster    1..16473
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /kind="single"
                     /product="Pyruvate2acetate-formate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16473
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Pyruvate2acetate-formate"
                     /region_number="1"
                     /rules="((PFL_acetate1 or PFL_acetate2) and Radical_SAM)"
                     /tool="gutsmash"
     CDS             326..1105
                     /locus_tag="ctg57_1"
                     /transl_table=11
                     /translation="MDKATQAYNDSSIQVLHGLEAVRKRPGMYIGSTDGRGLHHLVYEI
                     VDNSVDEALAGFGDEINVTIHADNSVTVQDHGRGMPTGMHPSGKPTIEVILTVLHAGGK
                     FNQNSYKTSGGLHGVGSSVVNALSESLTVRVVRDKHAFEEHFINGGHPDGSLQKLGKVN
                     EPNGTTITFKPDPTIFQTTVFSYDTLAERLRESAFLLKNITINLTDERTGKHDSYHYPD
                     GLVSFVKYLNEGKDALSQVINFEGKKDGIVVDFAGQI"
     CDS             1083..2339
                     /locus_tag="ctg57_2"
                     /transl_table=11
                     /translation="LILPAKYNDGYSENLISFVNNVRTGDGGTHEIGLRSGMTRAFNEF
                     ARKVGLLKERDKNLEGSDVREGFAGILSVRIPEEILQFEGQTKGKLGTPQARTVVDGIV
                     YDKLSTFLMENGEESQELVRKAVKARDAREAARKARDDSRTGRKRKKDQGLLSGKLTPA
                     QTKNPKRNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVLNTQKAKLQDIVKNEEINT
                     MIYTIGAGVGADFDLQQANYDKIIIMTDADTDGAHIQILLLTFFYRYMRPLIDAGRIYI
                     ALPPLYRLQKGAGAKTKISYAWTDEELAKETKAMGKGYTLTRFKGLGEMNADQLWETTM
                     NPETRTLIRVRIDDAQLAERRVTTLMGDRVEPRREWIEHNVKFDMDDDGSILETPTANH
                     EKLQFGAKQIVKQLDKKGK"
     CDS             2346..4790
                     /locus_tag="ctg57_3"
                     /transl_table=11
                     /translation="LANQIQELTLEEVMGDRFGRYSKYIIQERALPDVRDGLKPVQRRI
                     LFAMNQDGNTYDKGFRKSAKSVGNVMGNYHPHGDSSIYEAMVRLSQDWKLRAPLIQMHG
                     NNGSMDGDPPAAMRYTEARLSKISKEMLADIDKETVDMVLNFDDTAQEPTVLPAGFPNL
                     LVNGATGISAGYATEIPPHNLREVINAVLYLLKHPTADLDTLMQYVKGPDFPTGGIIQG
                     LDGIKQAYETGRGKIVVRSRTHIETIRGGREKIVVTEIPYDVNKAQMIKKIDELRINKK
                     VDGIAEVRDESDRFGLSVVIELKKEADAHGILNYLFKNTDLQIAYNFNMVAIADMQPKL
                     LGLKAMLEAYVEHRRDVVTRRTRFDLNKAAARQHIVEGLIKMLSILDQVIAAIRASKDK
                     GDAKRNLVKKFDFSEAQAEAIVSLQLYRLTNTDITALQKEAAQLAKAIAEYQDILARPA
                     ARDRVIEGELKRIAKEYGDDRRSSIQAKIETLEVATTVTVADETVMVQVSRDGYVKRSS
                     LRSYQAVDPADNGLKANDLAIFTGELSTLQHLYIVTNAGNVIYRPVHEISDARWKDTGE
                     HLSQTVGLGTDEKVLAVFAFDQLDGAGSFVLGSSDGYIKQTALSDLQPQRTYKSKPMMA
                     MKLKAPAAIVTNAYFTTDQQQDVFVVSRHAYGLTFPLSDVSTVGARATGVKSMDLKPDD
                     EVVNFILVKDPTMAKVGILTQRGAFKKMALSEVGEMSRARRGLLVLRELKRDPHRIVAM
                     MSVDDATRLNVLTDTGKVTTLNPVQHPAGDRYSNGSFVIDTDVLGKPVFVQTKEEPADQ
                     VE"
     CDS             5042..7303
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: PFL_acetate2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Gly_radical"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg57_4"
                     /sec_met_domain="Gly_radical (E-value: 5.2e-42, bitscore:
                     132.6, seeds: 99, tool: rule-based-clusters)"
                     /sec_met_domain="PFL_acetate2 (E-value: 2.2e-244, bitscore:
                     802.0, seeds: 33, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQLDETKVPNYWEGFNGGDWQEEINVRDFIEHNLNQYDGDESFL
                     AGPTEATTVLNNQVLNLKKQERANGGVLDADNNIPSTITSHGPGYLNKDLEKIVGVQTD
                     KPFKRAFMPFGGIRMAEDALESYGFKTDPQEHKIFNEYRKTHNQGVFDAYTPDMRKARH
                     YKIVTGLPDAYGRGRIVSDFPRIAVYGIDRLMAEKFKDYNLTGDGEMTDDVIKLREEIN
                     EQYRALNDMKKMAKEYGYDISRPAANAQEAVQWIYFGYLAAVKTQNGAAMSVGRIDTVI
                     DAYIQRDMRLGKLNEEQAQELIDHLVMKLRMVRFIRTEEYNSLFSGDPIWATLSLAGMG
                     NDGRHHVTKTAFRFLKTLDNMGAAPEPNITLLWSERLPEGFKRYATEVSIQSSTIQYEN
                     DDLMRNEWGTDYYGIACCVSAQPIADGVQYFGARANLAKTVLYAINGGKDEIQEAQVGP
                     EYAPITSDYIDYKEFMNKFDKMMDWLADTYVNALNVIHYMHDKYYYEAAQLALKDTQLN
                     RTFATGISGLSHAVDSISAIKYGHVKAIRDENGVAVDFVADNDDYPRYGNNDDRADDIA
                     KWLVKTFYNKMNTHHLYRGAKLSTSVLTITSNVVYGKNTGTTPNGRQKGEPFSPGANPA
                     YGAEKNGALASLMSTAKIPYHYATDGISNTFGVTPNTLGHDDETRKDTLVHMVDGYMEN
                     SGMHLNINVFNKETLIDAQKHPEEYPTLTVRVSGYCVYFADLTKEQQDDVIARTFFEEM
                     "
     CDS             7435..7950
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: Radical_SAM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1015:4Fe-4S single cluster domain (Score: 66.8;
                     E-value: 7.8e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg57_5"
                     /sec_met_domain="Radical_SAM (E-value: 1.8e-22, bitscore:
                     70.2, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLIDQSQSPLNILEQVGQDHDGPIKGYVHSVESFGSVDGPGIRF
                     VVFMQGCRMRCQYCHNPDTWNIGVGEEMTADQILADAQRYKAFWGDQGGITCSGGESLV
                     QIDFILELFTKAKALGISTCLDTSGGPFTRDQPWFGQFEKLMAVTDISLVDIKHIDSAE
                     HKKAHRFS"
     CDS             7979..8287
                     /locus_tag="ctg57_6"
                     /transl_table=11
                     /translation="MSAHGDDMWIRHVLVPERTDFDPYLKRLGDYIATLDKNVVQKVEI
                     LPYHTLGVKKYHELGITYPLEGIEPPSADRVKNAENLLHVKDYTGWQSWRPKPVASN"
     CDS             8412..9380
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HTH_1"
                     /gene_functions="regulatory (smcogs) SMCOG1012:Bacterial
                     regulatory helix-turn-helix protein, lysR family (Score:
                     60.8; E-value: 3.2e-19)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg57_7"
                     /sec_met_domain="LysR_substrate (E-value: 2e-27, bitscore:
                     85.7, seeds: 361, tool: rule-based-clusters)"
                     /sec_met_domain="HTH_1 (E-value: 6.7e-20, bitscore: 60.8,
                     seeds: 1330, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTKQERIFSSKTLTYFLQLAETMNYTQAAQLLGITQPALTQQIK
                     KLERTVGAPLFYSVGKKLHLSDAGQTMLKSTHEIYEILNQTTDEIQQTTSATVGKINIG
                     LLSSIEDSAFIAFIAHYYQLNPEVEVTLRMMTRHEIWESLENNQIDLAIMNLPDETIKN
                     WKPYASKKIIDEQLLFLHHDDALANRKRIHFKDTLAEPWATYPDDYFLGQLLREAYKNQ
                     MVDFPHVVAHFTTPYQLTQFVNLSGVNTALPTSFVRARADQIKAYAIAFDPAIRFEISF
                     VYRKEKADIPRISNFFQTFDDYLKEKDYLSRVSENRVKLDK"
     CDS             9410..10342
                     /locus_tag="ctg57_8"
                     /transl_table=11
                     /translation="MTTLIFGHQNPDTDAITSAMSWAEFQKQAGNTDVEAVALGEPNDE
                     TKFVLDHFKVQAPRVIKTAANETDHVMLVDHNEFQQSVSDIEDVTIDSVVDHHRIANFH
                     TAAPLFYRAEPVGSTNTVIFEMFQEYGFKISPTLAGLMASGLISDTLLLKSPTATDKDK
                     KILPEMAKIAGIDLQSYGLAMLKAGTNLAAKSDMDIIEGDAKSFTMGGKSIRIGQVNTV
                     DLNDIYARQDELISAMTKEAQAKGYDDFLLIATDILDSNSTGFAVGADRDKIASAFNEQ
                     FDKDARLALPGVVSRKKQVVPPMQSTFEG"
     CDS             11504..12616
                     /locus_tag="ctg57_9"
                     /transl_table=11
                     /translation="VSTQNYSKLIHTMLPALPDYIQDYYQSQKAIPIADSTLYQYLHFY
                     QEFLNWLINSGVTAASSPQTVPLTVLEHLSLRDAQAFMAYLLERPSKTHHNKRMTRRSV
                     ALRLVGIKALYRFLTEESEPHADGEPYFYRNVWNKVKLKTHTETASYRNHKLQEMLFVD
                     GEDAKFLQWLDQSYAQQLPAKPRRYFEATKVRNLAMIALLFGSGVRVSELVNMNLEDLN
                     MDRHTVQVVRKGNFQDRVNFADWIDPYVQAYLTQRAAIIGYQKPTSPLFVTVVGQKINR
                     IRQNTIEAFFKRYTTDYGRPSTPHKARHTLGTNIYTVTKDVQQVADQLGQTTTSATDLY
                     INLSDKSGKEALREVSETAAKATDRGHDQA"
     CDS             12723..13076
                     /locus_tag="ctg57_10"
                     /transl_table=11
                     /translation="VLDVKDSVNRLAWTTEHHFLHIQARHDFMRAWAVQFEMAYTDFRV
                     IQMALQLGGEQYHDLLKRFAAAYEAVYAYEYAFAAGGLAGFDEQFADKMADYQTAEQTL
                     LKIIDEIKALQPA"
     CDS             complement(13143..15134)
                     /locus_tag="ctg57_11"
                     /transl_table=11
                     /translation="MKFYFKLAASNLKADRRLFVPFVTTTSFLMAVNLIMLNAYASSDV
                     LFKKLGAAAGKSLFMFGTDVIVIISVILAIYANNFLRKQRIRQLGLYNIIGFGKGELGK
                     MMAVEKLLLLLTTLLFGGILGTVLSRISYLALAKMLKVDHNLDFGLSQQAFSIAGIITI
                     GLFVVLLLVDELWLIRKRPIEIVRAQRAGEREPKTKWVTLIVSLIALIAGYYIAVTTTN
                     PLQAMSMFFVAVILVICGTYGLFTAGSVFVLKWLRNRKNYYYKPKHFINVANLLYRMQQ
                     NGAGLASIAILVTMTLITLASTATLFFGINEVVNTNTPVDLSYVLKANDTTAPGKVARM
                     ASANHVIIKSQHTFVGPSSTMALLDGNRLESQANVNGPFSMGNARSVQLMTIESYNRFT
                     GHHARVKSGEVLIYTSKNFPSKTIRIGQKTYRIGKRAGSFPNAQATFIPNLFIAFPEEK
                     QMIDAMQHLRNARYQNAAEAQADITTSQDVMLQGSHANQLKLYEAVVKGRIAESASVQS
                     KAVNYDETMSIMGSFLFLGIIFGVTFILATLLILYYKQLSEGYADARRYTILQRVGLSL
                     REVRATINSQLLMLFYLPLLVAGIHVGFALPFIQRIMILFGLPNWQFFLTVSLITLGIF
                     AIIYVLMYKLTGNVYYRIVSRRQATSRS"
     CDS             complement(15131..15901)
                     /locus_tag="ctg57_12"
                     /transl_table=11
                     /translation="MSTLLKLKNIEKTYTSRGAQPVRALTNISFTVEAGEFVAIMGESG
                     SGKSTLLNLIATLDDPTGGDISLNGQDLSNVKEGARAKFRREHLGFIFQDFDLLDTFNV
                     QDNIFLPLVLAKKPLEIMRNRLTKLAPRLGIDALLKKYPYELSGGQQQRVAAARAMITE
                     PEILLADEPTGALDSKTSTELLDLLTDVNAENRQTILMVTHSAVAASHSRRVLFIRDGQ
                     IFHQLYRGDLDQPAFLTRISETMTAMLTKAGDGQ"
     CDS             complement(15995..16471)
                     /locus_tag="ctg57_13"
                     /transl_table=11
                     /translation="KLTTLNTDLVLTELPLKPLVNETVRDLAKLFIAKDLTVTVGPLPT
                     VISDSQWLHFIFEQLLTNAIKYTPHGSIKIYAKGDAVMVADTGIGILAEDLPRIFEQGY
                     SGYNGRANQKASGLGLFLSKQIAEKLGLTLTVTSEIGQGSTFAIHFPQTRWQVE"
ORIGIN
        1 tcctgctcgc gctctactga aacgcgttca ccagcccaga aacctgcaca taaggacctt
       61 gggcacaatg gtcaaagccc aaccatcgca cccaaggccg cttatgctcc ggtttctaat
      121 cgggctgctc tattgaaacg cgctcgcagt cgcagcaacc tgcgtgtaag gaccttggcc
      181 gcaatggtca aagcccgacc atcacgtcca aggccgctta cactccggtt gctaaccgct
      241 cctgctcgcg ctcttatttt ttatttctga aatctcaacg cgtggtgtat tctataactt
      301 agttgttcaa aaaagggagt ttactatgga taaagcaacg caagcatata atgattcatc
      361 cattcaggtg ctgcatggct tggaagctgt gcggaagcgt ccggggatgt atattggttc
      421 caccgatggc cgcggtttgc atcacttggt ctatgaaatc gtggacaact ctgtcgatga
      481 agcgctcgcg gggtttgggg atgagatcaa tgtgacgatt cacgccgata actctgtgac
      541 cgtacaggat catggtcgcg ggatgccaac ggggatgcac ccgagtggca aaccgacgat
      601 tgaagtcatt ttaaccgtgc tacatgccgg cggaaagttt aaccaaaata gttacaaaac
      661 ttctggtggt ttgcatgggg ttggctcaag cgtcgtcaat gccctatcgg agtcattgac
      721 tgtgcgagtt gtgcgggata agcacgcatt tgaggagcat tttatcaatg gcggtcatcc
      781 tgatggcagt ttgcagaagt tgggcaaagt taatgaacct aatggcacga ccatcacgtt
      841 caagccggac ccgactattt ttcaaaccac cgtcttcagt tatgatacct tggccgaacg
      901 cttgcgcgaa tcagcctttc tactgaaaaa tattacgatt aatctgactg atgaacgcac
      961 cggcaagcat gacagttacc actatcctga tggcttggtc agttttgtta aataccttaa
     1021 tgaaggcaaa gacgcattgt cacaggtgat caattttgaa ggcaaaaagg acggtatcgt
     1081 ggttgatttt gccggccaaa tataacgatg gctattctga aaacctgatt tcgtttgtta
     1141 ataacgttcg cactggtgat ggcgggacgc atgaaattgg cttgcgcagc ggcatgaccc
     1201 gtgcattcaa tgaatttgcc cgaaaagtcg gcttgctgaa ggaacgcgac aagaaccttg
     1261 aaggcagtga tgtgcgtgaa ggttttgcag gtattttaag tgtccgcatt ccagaagaaa
     1321 ttttgcaatt tgagggccag acaaagggca agcttggtac gccgcaagcc cgcactgtgg
     1381 tcgatgggat tgtctatgac aagctgtcaa cttttttgat ggaaaacggt gaagagtcgc
     1441 aagagttggt tcgtaaagcc gtcaaagccc gtgatgcgcg ggaagcggct cgaaaagcac
     1501 gcgatgatag ccggacggga cgcaagcgca agaaggatca aggcttgctt tccggtaaat
     1561 taaccccggc gcaaaccaag aaccctaagc gtaacgaatt gtatctcgtc gaaggggatt
     1621 ctgccggtgg ttcagctaaa caaggccgag accggaagtt tcaggcgatc ttgccattgc
     1681 gagggaaagt actgaatacc cagaaggcca agttacaaga catcgttaaa aacgaagaaa
     1741 tcaatacgat gatttacacc atcggcgctg gtgtcggtgc ggattttgat ctgcagcagg
     1801 ccaactacga caaaatcatt attatgacag atgcggatac tgatggcgcg catattcaga
     1861 ttttgctact aaccttcttt tatcgctaca tgcggccgct gattgacgca ggccgaattt
     1921 acattgcttt gccaccattg tatcggctgc aaaaaggcgc cggtgccaaa accaagatca
     1981 gttatgcttg gaccgatgaa gagttggcca aagagaccaa ggccatgggc aagggttaca
     2041 cattgacccg atttaaagga cttggggaaa tgaatgccga ccagctttgg gaaacgacta
     2101 tgaatcctga gacgcggact ttgatccggg ttcggattga cgatgctcag ctggcggaac
     2161 gacgcgtgac cactttgatg ggtgatcgcg ttgagccgcg tcgtgaatgg attgagcata
     2221 acgtcaagtt tgatatggat gacgatggca gtattttgga aactccgact gctaatcacg
     2281 aaaaattaca gtttggtgcc aagcaaatcg tcaaacaact ggacaagaaa ggaaagtaaa
     2341 agccattggc caatcagatt caagaactga ccttagaaga ggtcatgggc gaccggtttg
     2401 gccggtactc gaaatacatt attcaagaac gggcgctgcc tgatgtgcgt gacggcctta
     2461 aaccggttca gcgtcgcatt ttatttgcga tgaaccaaga tggcaatacg tatgataagg
     2521 gcttccgcaa gtcggctaaa agtgtcggga atgtcatggg taattatcat ccccacggcg
     2581 acagctccat ttatgaagcg atggttcggc taagccagga ttggaagtta cgggccccac
     2641 tgattcagat gcacgggaat aacggttcca tggatggtga tccgccagct gcaatgcgat
     2701 atacggaagc gcgtttaagc aaaatcagca aggaaatgct ggccgatatc gataaggaaa
     2761 ccgtcgatat ggtgttgaac tttgatgaca cggcacagga accaactgtg ttgcccgcag
     2821 gatttccgaa tttgctggtg aatggtgcaa cgggcatctc tgcaggttac gcgaccgaaa
     2881 ttccgccgca taacttgcgc gaagtgatca atgcggtctt atatttgctg aagcatccca
     2941 ctgctgattt agatacttta atgcaatacg tcaagggtcc cgattttcca acaggtggga
     3001 ttattcaagg gcttgatggt atcaagcaag cttacgaaac cggccgcggt aaaatcgtgg
     3061 ttcgttctcg gacacacatc gaaaccattc gtggcggtcg tgagaagatc gtggtcactg
     3121 agatcccgta tgatgtcaat aaagcgcaga tgattaaaaa aatcgatgaa ttacgcatca
     3181 acaaaaaagt ggacggtatc gccgaagtcc gtgacgaaag cgatcgtttt gggcttagcg
     3241 ttgtcatcga attaaaaaaa gaagccgatg cacatggcat cttaaactat ttatttaaaa
     3301 ataccgatct gcaaattgca tacaacttta acatggtcgc tattgccgac atgcagccga
     3361 agttgctagg acttaaggcc atgttggaag catacgtcga acatcgacgc gatgtggtca
     3421 ctcggcgaac gcgttttgac ctcaacaagg ccgctgctcg acagcacatt gtcgaaggct
     3481 tgatcaaaat gctatcgatt ttggatcaag tcatcgccgc gattcgtgct tccaaggata
     3541 aaggggatgc taagcgtaac ttagtcaaga agtttgattt ttcggaagct caggcggaag
     3601 cgattgtttc cttgcagctg tatcgattga ctaataccga tatcacggct ttacagaaag
     3661 aagcagcaca attggcgaaa gcaatcgccg agtatcaaga tattttggcc cgccccgctg
     3721 cccgcgatcg ggtgattgaa ggcgagttga agcggattgc caaggagtac ggggatgatc
     3781 gtcgcagcag cattcaagcc aaaattgaaa cacttgaagt ggcgacaacg gtgacggtgg
     3841 ctgatgaaac cgtcatggtg caggtttctc gtgatgggta cgttaaacgc agttcactgc
     3901 gcagttatca ggcggttgat ccggccgaca atggtttgaa ggccaatgat cttgccattt
     3961 tcactggcga actgagtacg ttgcagcatc tttacatcgt gacaaatgcc ggaaatgtca
     4021 tttatcgacc agtgcatgaa attagtgatg cgcgttggaa agacaccggc gaacacttaa
     4081 gccaaacagt tggccttggc actgacgaaa aagtcttggc agtgtttgct tttgatcaac
     4141 tcgatggcgc tggcagtttt gtgttagggt caagtgacgg gtacatcaaa caaactgcct
     4201 taagtgattt gcagccgcaa cggacgtaca agagtaagcc gatgatggcg atgaagctga
     4261 aagccccagc cgcgattgtc accaatgcat acttcacgac tgatcagcaa caggatgtct
     4321 ttgtggtcag ccgccacgct tacggactga cattcccgtt aagcgatgtg tcaactgtcg
     4381 gtgcccgggc aaccggcgtt aaaagtatgg atctaaagcc agacgatgag gttgtcaatt
     4441 tcattctagt gaaggatcca actatggcta aggtcggtat tttgacccaa cgtggcgcct
     4501 tcaaaaagat ggccttaagc gaggtcgggg aaatgagtcg tgcccgtcgt ggtttactgg
     4561 tcttgcgtga gcttaagcgt gatccgcatc ggattgtcgc gatgatgtca gtcgatgacg
     4621 ctacccgcct gaatgttttg accgatacgg gtaaggtaac gacccttaat ccggtacaac
     4681 atccagcagg tgaccgctat tcgaatggtt cgtttgtcat tgacactgat gtccttggca
     4741 agccagtttt tgttcaaacc aaagaagaac cagcagatca agtcgaataa atggtgatca
     4801 ttgacgccgc cgtctgtact aatacagatg gtggcgtttt tgattattat aggacagatc
     4861 agttgtgcac aatttaacaa aatgacgaaa tcatgggcga aaagaagcga cgaagcacac
     4921 ttaaaaaaca atataacgcc tattatatgg gcaataaaac gcttgcatag atttggcggc
     4981 gtgttatact gtgtttgtaa gaactgtcac atctgtaatc cactttagga ggcaaacaac
     5041 tatgaaacag cttgacgaaa ccaaagttcc taattattgg gaaggcttta acggtggcga
     5101 ctggcaagaa gaaattaatg tgcgcgattt tatcgagcat aacctgaacc aatatgacgg
     5161 ggacgaaagt ttccttgctg gccccactga agcgacaaca gtcctgaaca atcaggttct
     5221 aaatttaaag aagcaagaac gtgcaaatgg cggtgttttg gatgctgaca acaatattcc
     5281 atctacgatc acctcacacg gccctggtta tttgaacaaa gatcttgaaa agattgttgg
     5341 tgttcagacc gacaagccat tcaaacgagc attcatgcca tttggcggta ttcgaatggc
     5401 tgaagatgca ttggaatctt atggcttcaa gacagatcct caagaacaca agattttcaa
     5461 tgaatatcgt aagacccata accaaggtgt ctttgatgct tatacccctg atatgcgaaa
     5521 ggctcgccat tacaagatcg tgactggctt gccagacgca tacggccgcg gccggattgt
     5581 ttctgatttc ccacggatcg ctgtttacgg gatcgatcgt ttaatggctg agaagttcaa
     5641 ggattataac ttgaccggcg acggcgaaat gactgacgat gtaatcaaat tgcgtgaaga
     5701 aatcaatgaa caatatcgtg ccttaaacga catgaagaag atggccaagg aatatggcta
     5761 tgacatctcg cgtccggcag ctaatgcgca agaagctgtt cagtggatct actttggcta
     5821 tctggctgct gttaagactc aaaacggtgc cgcaatgtcc gttggccgga tcgatacggt
     5881 tattgatgct tatatccaac gcgatatgcg cttaggcaaa ttgaacgaag aacaggcaca
     5941 ggaactgatt gatcatttgg ttatgaaatt gcgaatggtt cgtttcatcc ggactgaaga
     6001 atataactca ctgttctcag gcgatccaat ctgggcaacc ttgtcattgg caggaatggg
     6061 caatgatggc cgtcaccacg ttaccaagac ggctttccgt ttcctgaaga ctttggacaa
     6121 catgggcgca gcaccagaac caaacatcac cttgctttgg agcgaacgct tgccagaagg
     6181 cttcaaacgc tatgcaaccg aagtatccat ccaaagttca accattcaat atgaaaatga
     6241 tgacctgatg cgcaacgaat ggggtaccga ttactacggt attgcttgct gtgtctcggc
     6301 acaaccaatt gccgatggcg ttcaatactt tggtgcccgt gctaacttag ctaagacagt
     6361 tctgtatgcg atcaacggtg ggaaagatga aattcaggaa gcgcaagtag ggcctgaata
     6421 tgcaccgatc accagcgatt acattgatta caaagaattc atgaataagt tcgacaagat
     6481 gatggactgg ctggccgaca cgtatgtcaa tgctttgaat gtgattcact atatgcatga
     6541 caagtattat tatgaagctg cacagctggc attgaaggat acccaactga accggacctt
     6601 cgcaaccggg atttccggcc tgtcacacgc ggttgattcc atcagtgcaa tcaagtatgg
     6661 tcatgtcaag gcaattcgcg atgaaaacgg tgttgcagtt gacttcgttg ctgacaatga
     6721 tgactatcca cgttatggta acaacgatga tcgcgctgat gacatcgcta agtggttggt
     6781 taagaccttc tataacaaga tgaacacgca tcatctgtat cgcggcgcga agttgagcac
     6841 cagtgtcctg accattacct ccaacgtggt ttatggtaag aatacaggga caacaccaaa
     6901 cggtcgtcaa aaaggcgaac cattctcacc aggtgccaac ccggcatatg gcgcagaaaa
     6961 gaacggcgca ctggcatccc tgatgtccac cgccaagatt ccgtatcatt acgcaactga
     7021 cggcattagt aatacgtttg gggttactcc gaacacactg ggccacgatg atgaaactcg
     7081 taaggatacc ttggtacaca tggttgacgg ctatatggaa aacagcggca tgcatttgaa
     7141 catcaacgtc ttcaataagg agaccctgat tgatgctcag aagcacccag aagaataccc
     7201 aacattgacc gttcgggttt ctggctactg cgtctacttc gcagatttga ccaaggaaca
     7261 acaagacgat gtcattgctc ggaccttctt cgaagaaatg taagcagctt aactcaagac
     7321 aggaagccat tcctgttttg ccaaaagacg gcaacgatgc tgttgccgtt ttttggcaga
     7381 atgaaatgaa aatcaattga aaacgacaca tgatgttgta gtggaggcaa taagatgaaa
     7441 ctcatcgatc agtcacaaag cccattaaat atcttagaac aagttggtca ggatcatgat
     7501 ggcccgatca aagggtatgt tcactcggtc gaaagttttg gttcggtcga tggccctggt
     7561 attcgcttcg ttgtctttat gcaagggtgt cgcatgcgtt gccagtattg tcacaaccct
     7621 gacacctgga acattggggt tggtgaagaa atgacggccg atcaaatttt ggcggatgcc
     7681 cagcgctata aagcattctg gggtgaccaa ggtggtatta cctgcagtgg cggtgagagt
     7741 ttggtacaaa tcgatttcat tctcgaactc ttcaccaagg ctaaggcact gggaatttcg
     7801 acttgcctcg atacgtcagg cggccccttc acgcgtgacc aaccgtggtt tggccagttt
     7861 gaaaagctga tggctgttac tgacatctca ttagttgata ttaaacacat tgattcggcc
     7921 gagcataaaa aagctcaccg gttttcctaa tgaaaatatt ttggatatgg tgcagtatat
     7981 gtcggcgcat ggtgatgaca tgtggattcg ccacgttctg gtcccggaac gcactgactt
     8041 tgacccttat ctcaaacggt taggggacta tattgcgaca ttggacaaaa acgtggtcca
     8101 aaaagttgag attctgccgt atcacacgtt aggcgttaaa aagtatcacg agcttggcat
     8161 tacgtacccg cttgaaggca tcgaaccgcc gtctgccgat cgcgttaaga atgcagagaa
     8221 tctgctgcac gttaaggatt ataccggatg gcaaagctgg cgtccgaaac cagttgcgag
     8281 caactgaatt tttagctaga acttaacgta acgattaaaa acgcggcaaa ttcgttgcgt
     8341 tttttttcat tgccacttat gatgatggtt gaacgatatt attaaattat aaacgaaagg
     8401 gaagccgccc tatgaaaacg aaacaagaac gcattttttc ctcaaagaca ctaacttatt
     8461 ttctgcaatt ggcagaaacc atgaactaca cccaagccgc ccaattgctt ggcattaccc
     8521 agccagcctt aacacagcag atcaagaaat tggaacggac ggtgggggca ccgctgtttt
     8581 attctgtcgg gaagaaactg catttatctg acgctggtca gaccatgtta aagtcaaccc
     8641 atgagatcta cgagatcttg aaccagacaa ccgacgaaat tcaacaaaca accagtgcaa
     8701 ccgtcggaaa aatcaatatt gggttattaa gctcaatcga ggatagcgcc tttattgcgt
     8761 tcattgctca ttactatcaa ctgaatcctg aagttgaagt aacgctacgg atgatgaccc
     8821 gtcacgaaat ttgggaatca ttggaaaaca accagattga tttagctatc atgaatctgc
     8881 cagatgaaac cattaagaac tggaaaccat acgccagcaa gaaaattatt gatgaacaat
     8941 tgctgttctt gcaccacgat gacgccttgg ctaaccgtaa gcgaatccat ttcaaagata
     9001 ctttagctga accttgggca acttatcctg acgactattt ccttggacag cttctgcgtg
     9061 aggcgtacaa gaatcaaatg gttgatttcc cgcacgtggt cgcacatttc accacgccat
     9121 atcagttaac ccaattcgtt aacttgtcag gggtcaacac ggccttacca accagttttg
     9181 ttcgggcacg cgctgatcaa atcaaggcct atgctattgc gtttgatccg gccattcgct
     9241 ttgagatttc ttttgtttat cgcaaagaga aagctgacat tccgcggatc tcgaacttct
     9301 tccagacctt tgacgattat ctgaaggaaa aagattactt gtcgcgggtc agtgaaaacc
     9361 gtgttaaact tgataagtaa actattcagt tgaggagcga tcagataaga tgacgacttt
     9421 gatttttggg catcagaacc cggacaccga cgcgattacg agtgccatga gctgggcaga
     9481 atttcagaaa caggcaggca acacggatgt tgaagcggta gcattaggcg aaccgaacga
     9541 tgaaactaag ttcgtccttg atcacttcaa ggttcaggca ccgcgggtta tcaagacggc
     9601 agccaacgag acggatcatg tcatgttggt tgatcacaac gaatttcaac aaagtgtcag
     9661 tgatatcgaa gacgtgacga ttgattctgt tgtcgaccat catcgcatcg ctaacttcca
     9721 cacggcagcg ccgctgtttt accgagcaga accggttggc agcaccaata ccgtcatttt
     9781 tgagatgttc caggaatatg gcttcaagat ttcgccaaca ttggctggtt tgatggcttc
     9841 tggtttgatt tcagacacgc tgttgttgaa gtcaccgacc gcaaccgata aggataagaa
     9901 gattttgcca gaaatggcga agattgccgg aattgatttg cagtcatatg gtcttgccat
     9961 gctgaaggca ggtactaatt tggccgccaa gtcagatatg gacattatcg aaggcgatgc
    10021 taagagtttc accatgggcg gcaagtctat tcgcatcgga caggtcaata ccgtcgatct
    10081 gaacgacatt tacgcacgtc aggacgaatt gatcagtgcc atgaccaaag aggcgcaggc
    10141 gaaaggctac gacgatttcc tgctgattgc cactgacatc ttggacagca attcaactgg
    10201 tttcgcagtc ggtgctgacc gcgataaaat cgccagtgct ttcaacgaac agttcgacaa
    10261 ggacgcgcgt ttggcattgc ctggggttgt ttcccgcaaa aagcaggtcg ttccgccaat
    10321 gcagagcacg tttgaaggtt aactttcatc tttaattgca cacaattgtt ctaaggaaag
    10381 tcgcagctag ccagttgcgg cttttttgtt tgcaaaaagt ctctagccat ctttttgcga
    10441 aatctgttaa atataaagct gacaagcagc tcgtgatgcg tgaatttgaa attcgtgtag
    10501 taattcgcgg gtcgaatcaa cagcgagttg tcatgggtca ttttggatgg ttttgaggca
    10561 tgctgagaga cgcattctga gacgagttcg ggaattcaac ttgatagttg ttcgtcgcaa
    10621 gtgacttaac gaaaaaactc aagcaaaaaa atatcgaatg atttccaatg attgtagaag
    10681 cttttaaaga cttggctgca agcagcggtt caaaaaatga ggcgactatt gggtgctgta
    10741 tgaaattgcg aatcaaataa tcgccaacgt aaatattgcg agaatggcac gatgccgtct
    10801 cttcaaacac tacttcgcat aatatatatt atgtaaacta gaatatgaat aattggcttt
    10861 ggcacttgat ctgcgaatct gggtgtcccc tctttcagat ggctgtcaaa aatttgtggt
    10921 ccggacgtaa tgttggtggt ggcgattgca ttttttacca aggcaatcaa ttatgaattg
    10981 gatctttgcg tttacgctga gtttacgctg agttgcatgc atttgtttga ttgaaaatgt
    11041 catgctagcc aaaaccagaa aaatgcatat caattcaagc ttcatgatgt tgtgagattc
    11101 tcgtcagtta gccgacttcg agttgcttga tgattttttg agttgtgtag tttgaaattg
    11161 actcaacaac aattgagggt cacgtaacat tcagcaaatt tattttgttg accaatggcc
    11221 aaaataagtt tgctgaatga ttgaccgaag tgaactcatt taatagccga attcatgcca
    11281 gaattatgcc agctaaaatt tgtctggcca acaggcgttt gctgacatct ttgctcacct
    11341 ttggataaag ctaaaacttt attcaattct gcttcacatg gcagaacaat ggctgaacca
    11401 gcaccaccgt tcatttttca tcaacactag ccctcgccaa ggacagttgt tttcgcgtat
    11461 actaacatta tctaaaagaa aacatacgtt cgaggtgaaa tctgtgtcga cacaaaatta
    11521 ttcgaaatta attcatacaa tgctacctgc cctgccggat tacattcagg actattatca
    11581 gagccaaaaa gcgatcccga tcgccgattc gacgctttat cagtatttac atttttatca
    11641 agagtttctg aactggctga ttaacagtgg tgtgacggcc gcttcctcac cgcaaaccgt
    11701 cccgctgacc gtgttagaac atttgtcgtt gcgtgatgcc caggcattta tggcgtattt
    11761 gcttgaacgg ccttccaaga cgcaccacaa caagcgaatg acgcgtcgca gtgttgcttt
    11821 gcgcttagtc gggatcaagg cgctttatcg gtttttgacg gaggaaagtg aaccccatgc
    11881 agatggcgaa ccttatttct atcggaatgt ctggaacaag gtaaaactta aaacccatac
    11941 tgaaactgcg agttaccgaa accacaagct acaggaaatg ctgtttgtgg acggtgaaga
    12001 tgctaagttt ttacagtggt tggatcaaag ttatgcgcaa caactgccag ccaagccgcg
    12061 gcgctatttt gaggcgacaa aagtgcgcaa cttggccatg attgccttac tatttggctc
    12121 aggagttcga gtcagcgaat tggtgaatat gaatctggaa gatttgaaca tggatcggca
    12181 tacggtccaa gttgttcgca aaggcaactt tcaggatcgc gtcaattttg cagactggat
    12241 tgatccgtat gttcaggctt acttaacgca gcgagcggct attatcggtt atcaaaagcc
    12301 gacttctccc ctgtttgtga cagttgtcgg ccaaaaaatc aatcggattc gccaaaatac
    12361 aatcgaagcc tttttcaagc gttatacaac cgattatggt cggccatcaa caccacataa
    12421 ggcccggcac actttgggaa ccaatattta tacggtcacc aaggatgtgc agcaggttgc
    12481 ggatcagctc gggcaaacga ccacaagtgc gacagatctg tatatcaatc tcagtgataa
    12541 aagcggtaaa gaagccttgc gtgaggtttc tgaaacggcc gcaaaagcaa ctgatcgcgg
    12601 gcatgaccaa gcttaattga cgagggatgg ttactgaagt tgatcatcga gtcttttgaa
    12661 agcttattcc gccagaccgg cctataatcg agtcagatcg aaacgggaag gtgggattga
    12721 ttgtgttaga tgttaaagat tcagtgaacc gattagcatg gacaacggag catcatttcc
    12781 tgcatattca ggcccgacat gattttatgc gggcatgggc agttcaattt gagatggcgt
    12841 atacggactt tcgcgtgatt cagatggcgc tgcaacttgg cggcgaacaa tatcatgatt
    12901 tgctaaagcg gtttgcggcc gcctatgaag cggtgtatgc ctatgagtat gcctttgctg
    12961 ctggcgggtt ggctggtttt gacgagcagt ttgccgataa aatggcggac tatcaaacag
    13021 ctgagcaaac gctgttgaag atcatcgatg aaatcaaggc attgcagccg gcttaattgc
    13081 tggcatcaac gaaaaaagcg tcgagcgaca gtatttttac tggcgtttcg acgctttttt
    13141 agttagctgc gactggtggc ttggcgacgc gagacgatgc gatagtacac gttaccggtg
    13201 agcttgtaca tgaggacata gatgatcgcg aagatgccaa gtgtgatgag tgagacagtc
    13261 aggaagaact gccaattcgg taagccaaac aatatcatga tgcgttgaat gaatggcaat
    13321 gcaaatccga catgaatccc tgccacgagt aatggcagat aaaacagcat tagtaactgg
    13381 ctgttgatgg ttgcgcgcac ttctcgcaag cttaagccga cgcgttgtaa gatcgtgtag
    13441 cggcgggcat cggcatagcc ttcagataac tgtttataat acaagatcaa taaggttgcc
    13501 aaaatgaagg tgacgccgaa aatgatgccg aggaagagaa agctgcccat gatactcatg
    13561 gtctcatcgt aattcacggc tttcgattga actgaggccg attcagcgat acgacccttg
    13621 accaccgctt catagagctt aagctgattg gcatggcttc cttgcaacat cacatcttga
    13681 cttgtggtga tatcagcttg tgcctcagcc gcgttttgat agcgtgcatt tctcagatgc
    13741 tgcatggcgt cgatcatttg cttctcttca ggaaaggcaa taaaaagatt ggggataaaa
    13801 gtcgcttgtg catttggaaa gctacctgca cgttttccga tcctgtaagt cttttgacca
    13861 atgcgaatgg tcttgctagg aaaatttttg gatgtataaa tcaacacttc ccctgactta
    13921 acgcgggcat gatgcccggt aaaacggttg tagctctcaa tggtcatcaa ttgcaccgag
    13981 cgcgcattgc ccatactgaa cggaccattg acattggcct gcgattcaag acgattgcca
    14041 tcaagtaaag ccatcgtact ggacggtcca acaaaagtgt gttgcgactt gatgatgaca
    14101 tgattcgcgc tggccatccg tgccaccttg ccgggtgcag tggtgtcgtt tgccttgaga
    14161 acatatgaca aatcaaccgg cgtattcgta ttgacgactt cattgatacc gaagaacaac
    14221 gtggctgtgc tggcgagcgt aatcaaggtc atcgtcacca aaatggcaat agatgcaagg
    14281 ccagcgccgt tttgttgcat acgatagagt aaattagcta cattgataaa atgcttgggt
    14341 ttgtaatagt aatttttgcg gtttcgcaac cattttaaga cgaagaccga tccggcggtg
    14401 aacagtccat aagtgccgca gatgactaag atcacggcaa caaaaaacat actcattgct
    14461 tgtagtggat tagttgtcgt gaccgcgata tagtagccgg caattaaggc gataaggcta
    14521 acaattagcg tcacccactt tgtcttgggc tcccgctcac ctgctcgttg tgctcgcacg
    14581 atttcgattg gccgtttgcg aatgagccaa agttcatcaa ctaacagcaa aacaacgaat
    14641 aagccgatgg taatgatccc ggcgatactg aaggcttgct ggcttaaccc aaagtcaaga
    14701 ttgtggtcaa ctttgagcat tttggcgagc gcaaggtagc tgatgcggga aaggacagta
    14761 ccgagaatac caccgaacag taaagtggtt agtaacagca gcagcttctc cactgccatc
    14821 attttgccga gttcaccttt gccaaacccg atgatgttgt aaagtcctaa ctgacgaata
    14881 cgctgtttgc gcagaaaatt gtttgcgtag atggcgagaa tcacagagat aatcacgatg
    14941 acatctgtgc cgaacatgaa cagtgacttg ccagcggctg cccccagctt tttaaacaag
    15001 acatcactac tggcgtaagc attcagcatg attaggttga cggccatcag gaagctagtg
    15061 gttgtgacaa acggaacaaa caggcggcga tcggctttca agttacttgc agcgagctta
    15121 aagtagaatt tcattgtcca tcgcctgcct ttgtcagcat ggcggtcatc gtctcgctga
    15181 tacgggttag aaaggctggt tgatcgagat ccccacgata aagttgatga aaaatttgac
    15241 cgtcgcgaat aaataatact cgtcggctgt gactggccgc cacagcactg tgcgttacca
    15301 tgaggatcgt ttgccggttt tcggcattca catctgtgag cagatcaagc agttctgtag
    15361 aagttttgga atccaaggcg ccagtgggtt catcagccaa caaaatttct ggctcggtga
    15421 tcatcgcgcg tgctgccgcc acgcgctgtt gctggccgcc ggaaagctcg taaggatatt
    15481 ttttcagcaa ggcatcaatg cctagtcgtg gtgcgagctt agttagccga tttctcataa
    15541 tttcgagagg cttcttggca aggactaatg ggagaaagat gttgtcttga acattgaagg
    15601 tgtcaagcaa gtcgaaatcc tgaaagatga aaccgaggtg ttctcgacga aacttagccc
    15661 gggcaccttc cttgacgttg ctcagatcct gtccgtttag actaatatcg ccgccggttg
    15721 gatcgtccag cgttgcaatc agatttagca aggtgctttt gccagaacct gattcaccca
    15781 taattgccac aaattcaccg gcttcaacag tgaaactgat gttcgtcaag gcacgcaccg
    15841 gctgagcccc gcgactggta taagtttttt cgatattttt taatttaagt aatgttgaca
    15901 tgtgatcgtc ccctttcatt tattagctta gcggggatga tgccccatgc ctacttacag
    15961 tgactcgtag ttgcttacaa gctggtaagg tagcttactc cacttgccac cgcgtttggg
    16021 gaaaatgaat ggcaaatgtg ctgccttgcc caatttctga ggtgacagtt agcgtcaagc
    16081 caagcttttc agcgatttgt ttgctcaaaa atagccccaa accgctagct ttctgatttg
    16141 cgcggccgtt gtagccggaa tatccttgtt caaaaatccg cggtaaatct tcggccaaaa
    16201 ttccgatacc agtgtcggcc accatgacag catcgccttt ggcataaatc ttgattgaac
    16261 cgtgcggggt atatttaatg gcattggtga gcaattgttc aaaaataaaa tgcagccatt
    16321 gactgtcact aataacagtt ggcaatggcc ccacagtcac ggtcaggtcc ttggcgataa
    16381 acagcttcgc caagtcacga acggtctcat tgactaacgg tttgagtggc agttcagtta
    16441 aaacaagatc ggtatttaat gttgtcagct tca
//
