LOCUS       c00067_gnlPro..        14689 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|MGBOLGFJ_67.
ACCESSION   c00067_gnlPro..
VERSION     c00067_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 20:41:48
            Original ID  :: gnl|Prokka|MGBOLGFJ_67
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14689
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14689
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[5059:14122]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      5060..14122
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..14689
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14689
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             3..161
                     /locus_tag="ctg67_1"
                     /transl_table=11
                     /translation="PNKGTSHSNEVILAVSGDASAAKIAVLNARQTGLELLIGMGSYPE
                     IPGIPYL"
     CDS             511..999
                     /locus_tag="ctg67_2"
                     /transl_table=11
                     /translation="MPKNKFQEVIFTIIMVFVMVYAMICYNIVLNTGTMTNETFLLAFH
                     ELTFMGPIAFILDFFIIGGLAKKIAFGIVDMRIDNPFHLVLAISAVSVAFMCPCMSFAA
                     TVLIKHAPASQIIPTWLQTTAMNFPMAFFWQIFYAGPFVRFIFGKLFPEKEKAAASAE"
     CDS             1202..2200
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SBP_bac_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1044:Bacterial extracellular solute-binding protein
                     (Score: 56.8; E-value: 1.2e-17)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg67_3"
                     /sec_met_domain="SBP_bac_1 (E-value: 3.3e-18, bitscore:
                     56.8, seeds: 129, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRKLFAFGLAVVLALMPVQAFGKTVSVTNVSYDPTREMFEQYNK
                     IFEDHWKEKTGEDVEVIQSHGGSGKQALEVANGLDADVVTLALEYDIESIENAGLIKAG
                     WKDKFDNDSSPYTSTIVFLVKKGNPRDIKDWDDLTKKGVGVVTPNPKTSGGARWNYMAA
                     WAYADKKYGGDEAQMKEFIKKLYRNVVVLDSGARGATTSFVENGQGDVLVAWENEAYLS
                     MRDYPDEYEIVTPSVSILAQPSVAVVDEVVDYRDTRDVATEYLNYLYSDEAQEIAAENY
                     FRPTNEKILKKHSDTFDLNINLANISDYGGWDKVQKKHFTDGGIFDQIYER"
     CDS             2271..3107
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 83; E-value: 7.3e-26)"
                     /gene_kind="transport"
                     /locus_tag="ctg67_4"
                     /sec_met_domain="BPD_transp_1 (E-value: 2e-26, bitscore:
                     83.0, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKRNKPVIPGFGLSMGITISILSLVVLIPLASLVVYTAKLSFKD
                     FIETITRARVLASFYTSFVCAFAAAVINGIMGTVLAWVLVKYDFPGKRLMDGMIELPFA
                     LPTAVAGIALTSLTSDSGIVGSFFAGFGIKIAYTRTGITVAMIFVGIPFVVRSVQPVLE
                     KMDNSYSEAAGVLGAKKTTIFWKVIFPELKPAIFAGTGLAFGRCLGEYGSVVFIAGNKP
                     YYTEITPLVIMSELQEFDYSSATAIALVMLAVSFFILFLNSMIQQRNARILRGGNA"
     CDS             3107..3931
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 60.2; E-value: 7.1e-19)"
                     /gene_kind="transport"
                     /locus_tag="ctg67_5"
                     /sec_met_domain="BPD_transp_1 (E-value: 2e-19, bitscore:
                     60.2, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDNNEKTSEKITKWLLVGISVLFLAVMLLLPLITVITEALRSGWK
                     VYAAAVTDEYTIKALLLTVKATLFAVVFNTVFGVFAAWALTKFQFRGKKLLTTLIDLPV
                     TISPVIAGLIFLLIFGRQSPVYFFLMKLGMKVVFSVPGIIIATVFVTFPFISRELIPVL
                     EAEGSDEEEAAALMGAGGWTIFWKITFPHIKWALLYGVVLCTARAMGEFGAVSVLSGHL
                     RGKTNTLPLHVEILFNEFQYVPAFAVSSLLVIMAVIILVVRSLIEYKGKKEA"
     CDS             3933..4991
                     /locus_tag="ctg67_6"
                     /transl_table=11
                     /translation="MYVELKNINKTYGSYQASRNVNFGIEKGKLIGLLGSSGSGKTTIL
                     RMIAGLETPDSGEVIIDGKVVNDVPASQRGIGFVFQNYALFRYMTVYDNVAFGLKVQKA
                     DKKKIDARVRELIKLVGLEGLEKRYPSQLSGGQRQRVAFARALAPNPQVLLLDEPFAAI
                     DAKIRQELRSWLKEMIGKLGITSIFVTHDQDEAIEVADEIIITNAGRIEQKGTPIGVYR
                     NPETAFTASFFGQPSVLKNADDFHTFAQAEGADKIIVRPEFVKISKLDEVEKFKTSVSR
                     GVVERVSFRGDNLELQVRVNNSAVIARRSLEKADIREGETVNVFLYRIFALRGDSVQLI
                     ENEAVRDDFVII"
     CDS             5060..6805
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 72; E-value: 1.7e-22)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg67_7"
                     /sec_met_domain="FAD_binding_2 (E-value: 4.8e-23, bitscore:
                     72.0, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 1.9e-08,
                     bitscore: 24.6, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTERIRTDVLIIGGGTAGCFAAYVIGKKSGRKVLIAEKANIKRS
                     GCLAAGVNALNAYITEGRVPQDYVDYAKKDAHGIVREDLLLTMSERLNHVTKVMEDLGL
                     VILKDENGKYVARGNRNIKINGENMKPILAKAAAEQENVTVLNHVNITDYKTENKKVTG
                     AVGFSVNEDIFYDIDAKAVLCATGGAAGLYRPNNPGFSRHKMWYPPFNTGAGYAMGLLS
                     GAEMTTFEMRFIALRCKDTIAPTGTIAQGVGARQVNAHGDIYETKYGLTTSRRVYGTVM
                     ENREGNGPCYLRTEGISKEQEQDLYKAYLNMAPSQTLKWMEAGKGPSEENVEIEGTEPY
                     IVGGHTASGYWVDNNRATTIEGLYAAGDVAGGCPQKYVTGALAEGEIAAEAILEYLNGK
                     DDDRSAAENKEEALERGGEQELSQTAIAKKAEYESHLNASRSLMNAEQLEEAMQKIMDQ
                     YAGGISTDYRYSGMSLAKADEKIAALLPVVDTLAATDTYELMQIYELRERLIVCRAVIA
                     HLAARKETRWHSFGENTDYPQQSEEWMKYVNSRMENGEIKILYRDLITKENTGLNTAEK
                     GAGER"
     CDS             6802..7116
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_9"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg67_8"
                     /sec_met_domain="Fer4_9 (E-value: 2.2e-13, bitscore: 40.4,
                     seeds: 61, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_6 (E-value: 3.3e-09, bitscore: 26.9,
                     seeds: 134, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 3.3e-05, bitscore: 14.6,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIRIQKSKCAGCGRCIEACPGNLIKKDKENKAFIRQVRDCWGCT
                     SCIKECRHDAIRFFLGADVGGRGASMVVSEKPDISTWTVEKPDGTKITIQVNKKDANKY
                     "
     CDS             7206..8105
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PAPS_reduct"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg67_9"
                     /sec_met_domain="PAPS_reduct (E-value: 2.6e-65, bitscore:
                     209.9, seeds: 27, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNLSHLDALEAEAIYIMREVAAECEKPVMLYSIGKDSSVMLHLA
                     MKAFYPEKPPFPFLHIDTTWKFHEMIEFRDRIAKENGIDMLVYTNEEGVKAGINPFDNG
                     SAYTDIMKTQALKQALTKYGFTAAFGGGRRDEEKSRAKERIFSFRNSAQAWDPKNQRPE
                     MWKLYNTKIQKGESMRVFPISNWTEKDIWQYIQRENIEIVPLYFAKERPVIYRDGNIIM
                     VDDDRLKLRPGEKIENKKVRFRTLGCYPLTGGIESEADTLDEIIDETLSAVSSERTSRV
                     IDHEAAGSMERRKREGYF"
     CDS             8107..9747
                     /locus_tag="ctg67_10"
                     /transl_table=11
                     /translation="MKGLLKFITCGSVDDGKSTLIGHILYDAKLLYADQEKALELDSKV
                     GSRGGAIDYSLLLDGLMAEREQGITIDVAYRYFTTDNRSFIVADTPGHEEYTRNMAVGA
                     SFADLAVILVDASQGVLVQTRRHARICALMGIRYFVFAVNKMDLIEYDEKRFRDIENQI
                     AALIEELKLANVTIIPVSATEGDNVTTKSDNMPWYKGEALLSHLETVDIKEDTEKGFYM
                     PVQRVCRPNHEFRGFQGQIENGAIRAGDLVTTLPSKEEAHVKSILVGDKEVQEAVQGQP
                     VTIQLDREVDVSRGCVLTIDSGAVLTDSVEADILWMDDNALTDGKNFFVKIGTKMIPGL
                     VTKINYSVDVNTGEKKSAYTLKKNEIASCTLEFSEKIVVDEFDRHRTLGELILIDRVTN
                     MTSACGVVRKTFVSQDKSQIGKVDEQVRAGLKGQTPVVVEFPIGKEGITLDFAEQVEKG
                     LTVLGKHTYLYHPAASENYAETVRHLKAAGLIVLLVLDENTAKDETLKTLDGFYANWQI
                     DGITVKDAIDFVKKKSAFTVQSVHDGNYI"
     CDS             9892..10824
                     /locus_tag="ctg67_11"
                     /transl_table=11
                     /translation="MQTNNESKQNQKKEMLLGTFLTIVGGILWGISGVCGQFLFQNKEV
                     TAAWLVPIRLVTAGLLLLCYYFFKDKGKTFDIWKTKRNRTDIIVYGLAGMMLCQYSYFQ
                     TIEWSNAGTATVIQYLGPALIVVWVCFRTKRLPQKKEVLGVFLAVTGIFLIATHGNPTS
                     LALSQKALAMGLLSAVSVVVYTIKPARLQAQFPTPLVLAWGMLIGGAVLMAVFRPWDYQ
                     VIFDRETFAAVAFIIFFGTMAGFSLYLTGVKMIGSVKASLVSCVEPVASMVLTAVWMKV
                     SFTTPDLIGTLFVIATIIILAIPTKKRQK"
     CDS             11242..11496
                     /locus_tag="ctg67_12"
                     /transl_table=11
                     /translation="MRLEKVQEALKTKKIHYEYTEENGCGSIDFMFRGLRFHIWEYEDR
                     VWGAETNVFEAGRSQDIEGDYEEIISGEILSWPDMLPGM"
     CDS             11469..11597
                     /locus_tag="ctg67_13"
                     /transl_table=11
                     /translation="MAGYAAWDVSMLLFTATHSRELRYVKSNVSITAEGNDIYEKI"
     CDS             11575..12339
                     /locus_tag="ctg67_14"
                     /transl_table=11
                     /translation="MIFTKKYRTGQIVLTACIAAVCMFSDVHGAEVAGPPAPKSKSALT
                     QKPEATPMPASTPTPEQETETDKQNPADQGTLSKPDHLDTISADKLVFIGDSRTEGLRD
                     AVNDDSIWSCLSSMGYDWMVSTGVPQVEDQIEDNTAVIILMGVNDLYHVNDYISYINSK
                     AAEWGNRGAQTYFVSVGPVQNDPYCSNAEIESFNAAMQASLSGVTYIDVYSHLVSEGFS
                     TVDGTHYPDSVSVDIYNYILDHLEEQMSGIWG"
     CDS             12605..14122
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer4_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg67_15"
                     /sec_met_domain="Fer4_7 (E-value: 1.5e-11, bitscore: 35.0,
                     seeds: 208, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 1.8e-11, bitscore: 33.8,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 7.2e-06, bitscore: 16.7,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRGLYSSKTEIRHKIFTEIARMAYEGQSPEMLEELPYKIVPGEIA
                     TYRDSIFLERAVVGERLRVAMGMSLRKVTEHAPISKGVEASVIEEKYYEPPLINVIKFA
                     CNSCPEKRVMITEGCQGCLEHPCVEVCPKKAVHMEGGRSHIDEDACIKCGKCLEACPYN
                     AIIKQERPCSKACGMNAIGSDEYGRAEIDQDKCVSCGQCLVSCPFSAIVDKGQIFQTIM
                     ALKSETPVYAIVAPAIAGQFPGMENNKIRGAFQALGFTDVREVAVGADLCTVEEAKDFL
                     EEVPEKLPFMATSCCPSWSMMAKKLFPEQAKCISMALTPMVLTARLIKQKEPDCKIVFV
                     GPCAAKKLEASRKSIRSYVDFVLTFEEVAGMFDAKGVDWKDIPEGEPLFHASADGRGFA
                     VSGGVAEAVVHAVKRIDPDREVKVMNAEGLQNCKKMLQMAKIGKYNGYLLEGMACPGGC
                     VAGAGTIQTVKKAAAALEKMKKEASFTDAYDSKYRARLESLEKFDVE"
     CDS             14061..14186
                     /locus_tag="ctg67_16"
                     /transl_table=11
                     /translation="MPMTPNTEQDWKAWRNLMWSEILTESVKSYMDCKCLNAISI"
     CDS             complement(14294..14689)
                     /locus_tag="ctg67_17"
                     /transl_table=11
                     /translation="QGITCVIAGDIRNIRREKDLGHRTNQKFHSLPYNRIYIMLEYKLK
                     RYGIRFIKQEESYTSQCSPLSPKVEKRYAEPSKRKERGLYRDGNRTYNADAVGAYNILR
                     KYHSVSGVKRELSVTGLKTPEIIKVAV"
ORIGIN
        1 cgccgaataa gggaaccagc cattccaatg aagtgatcct ggcagtttcc ggagatgcca
       61 gtgctgctaa gatagcggta ttaaatgcca gacagacagg tctggagctt ctgatcggaa
      121 tgggcagtta tccggagata ccggggatcc cgtatttgta gagataaact ttgttcgtta
      181 ctgttcactc cgttcacagt aacgtagcca aaattcattc cagattgcct gcggcaatgg
      241 aattttggct tgtatgtctc gggattttgg catattcatg ccaaaacacc tcgcgggaca
      301 gtggtgtgtg aacagtaacc tttgtttcct gattcacact gcaggtactg aaaaaatcct
      361 tgactttttt taaaacagtc cgtataataa tcaacggtaa atttgtgaaa aagatatttg
      421 gtattattgg aaacggtaca tcctcctgga tggttatgaa caacacaaat ctctaattga
      481 tgttattcat actatctaag gaggattttt atgcctaaaa acaagtttca ggaagttatt
      541 tttacgatta tcatggtgtt tgtaatggtt tatgccatga tctgctacaa cattgtactg
      601 aacacaggga caatgacaaa tgagacattt ctgttagcct ttcatgaatt aacattcatg
      661 ggaccgattg catttattct tgatttcttt atcatcggtg gtcttgcaaa gaagattgca
      721 tttggtattg tggatatgag aatagataat ccgttccacc ttgtacttgc aatctcagca
      781 gtatccgttg catttatgtg tccatgtatg agctttgcgg caactgtgct gatcaaacat
      841 gcaccggcaa gtcagatcat tcccacatgg ctccagacaa cagcaatgaa ctttccgatg
      901 gcattcttct ggcagatttt ttatgccgga ccattcgtaa gatttatttt cggaaagctt
      961 tttccggaga aagaaaaggc agcagcttct gccgaataaa aaatatgtaa ttttgactgc
     1021 agcattctgt atttcaggat gctgcttttt ttgtgttctt atcttcacaa cataaattgt
     1081 acttatttta atacactatt gacaaattct gtcatttcct gtaatatcat ataaaacata
     1141 tcgaataact atgaaaagta gagaatgcaa aaaactactg gtaccttaaa ggagatgaaa
     1201 catgatcaga aaattatttg cctttggtct tgcagttgta ctggcactga tgccggtaca
     1261 ggcttttgga aaaacggtgt ctgtcaccaa tgtttcctat gatcctacca gagagatgtt
     1321 tgaacagtat aataaaatat ttgaagacca ctggaaggag aagaccgggg aagatgtgga
     1381 agtgatacag tcccatggcg gttcagggaa acaggcactt gaggtagcca atggtctgga
     1441 tgcagatgtg gtaaccctgg cactggaata tgatattgag tctattgaaa acgcagggct
     1501 gatcaaggca ggatggaaag ataaatttga caatgacagt tctccttata catccactat
     1561 cgtatttctg gtgaagaaag gaaatcccag ggatatcaaa gactgggacg atctgacgaa
     1621 aaaaggagtg ggagtagtaa caccaaatcc gaaaacctcc ggcggtgcca gatggaacta
     1681 catggcagcg tgggcttacg cagataaaaa gtatggtggc gatgaagcgc agatgaagga
     1741 atttatcaag aaactttacc ggaatgtggt ggttcttgac tcaggcgcaa gaggcgcaac
     1801 gacctctttc gtggagaacg gacaaggaga tgtgctggtt gcgtgggaaa atgaagctta
     1861 tctatccatg cgggattatc cggatgagta tgagattgtt actccaagcg taagtattct
     1921 ggcacagcct tctgtggcag tggtagatga agtggtggat tacagagata caagagatgt
     1981 ggcaactgag tatttgaatt atctgtattc cgacgaagca caggagatcg cagcagagaa
     2041 ttatttccgc cccactaatg agaaaatcct gaagaagcac agtgatacgt ttgatctgaa
     2101 tataaatctg gcaaatatca gtgattatgg cggatgggat aaagtgcaga agaaacattt
     2161 cacagatggc ggaattttcg atcagattta tgagagataa aggaagacaa gttgaagcaa
     2221 gagcataagc acagacagaa tatatgagac aggagaggtg gtaattgatt atgaaaaaaa
     2281 gaaataaacc ggtgattcca gggtttgggc tctccatggg aattaccatt tccatattga
     2341 gtctggtagt tctgatcccc ctggcaagtc tggtggtcta cacagcgaag ctgagtttta
     2401 aagattttat cgaaaccatc acaagggcca gagtgctggc atccttttat accagttttg
     2461 tatgtgcttt tgcagcagca gtaataaatg gaattatggg aactgttctt gcgtgggtgc
     2521 ttgtgaaata tgattttccg ggcaagagac ttatggatgg gatgatcgaa cttccctttg
     2581 ctcttcccac agcagtagca ggtattgcgc tgacatccct gacctcagat tccggaattg
     2641 taggcagctt ttttgcagga ttcggtatca agattgcata cacaagaacc ggcattacag
     2701 tggctatgat atttgtaggg ataccgttcg ttgtgcgaag tgtacagccg gttctggaaa
     2761 agatggataa ttcttacagc gaggcagcag gagtgctggg agcaaagaaa acaactatct
     2821 tctggaaggt catttttccg gaactaaagc ccgcaatctt tgcagggacc ggacttgcgt
     2881 tcggaagatg tctgggtgaa tatggaagtg ttgtatttat cgcaggaaat aaaccctatt
     2941 atacagaaat cacaccgctg gttattatgt cagagcttca ggaatttgat tattcaagtg
     3001 caacggcaat cgcacttgtg atgttggcag tttcattttt tattctgttc cttaacagta
     3061 tgatacagca gagaaatgca agaattttaa gaggaggaaa tgcctgatgg acaacaatga
     3121 aaagacttcg gagaaaatta caaaatggct gcttgtcggg atcagtgttc tgtttctggc
     3181 agtcatgctc cttcttcctc tgatcactgt gatcacagaa gcattgcgga gcggatggaa
     3241 ggtctatgca gctgcagtga cagatgagta caccatcaaa gcacttcttc ttacagtgaa
     3301 ggcaacactc tttgcagttg tttttaacac tgtttttggt gtttttgcag cctgggcact
     3361 gacgaagttt cagttcaggg gtaaaaagct tctcactacc ctgatcgatc ttccggttac
     3421 tatttcccct gttattgcag gtctgatctt tcttctgatt ttcggacgac agagtcctgt
     3481 ttactttttt ctcatgaagt tagggatgaa agttgtattc tctgtaccgg gaatcattat
     3541 tgcaactgta tttgtaacct ttccttttat ttccagagag ctgattccgg ttctggaagc
     3601 agaaggaagc gatgaggagg aagcagcagc tctgatggga gcaggtggat ggaccatttt
     3661 ctggaagatc acattcccgc atatcaaatg ggcattactg tacggagttg tgctctgtac
     3721 ggcaagagca atgggagagt ttggagcggt atctgtactt tccggacatt taagaggaaa
     3781 gaccaataca cttcctcttc atgtagagat tttgtttaat gagtttcagt atgttccggc
     3841 gtttgccgta tcttcactgc ttgtgatcat ggcggttatc attctggtag tcagaagcct
     3901 gattgaatat aaaggaaaga aggaagcctg atatgtatgt agagttaaaa aatatcaata
     3961 agacatatgg ttcttaccag gcatcaagga atgtgaattt cggaattgag aaaggtaaac
     4021 tgattggtct gttgggatca agcggaagcg gaaaaacaac tattcttcga atgatcgcag
     4081 gcctggaaac cccggacagc ggagaggtca ttattgatgg aaaagtggta aatgatgttc
     4141 cggccagtca gcgtgggatt ggatttgtat ttcagaatta tgcgttgttt cgctatatga
     4201 cagtttatga caacgttgca tttggtttga aggttcagaa ggctgataag aagaaaattg
     4261 atgccagagt cagagagctg atcaaactgg tggggctgga aggactggaa aaaagatatc
     4321 caagccagtt atccggcggt cagaggcaaa gggtagcatt tgccagagcc cttgctccaa
     4381 atccccaggt gctgcttctg gatgagccct ttgcagccat tgatgcaaaa atccgtcagg
     4441 aactgcgaag ctggttaaaa gagatgatcg ggaagctggg aattaccagt attttcgtta
     4501 ctcatgatca ggatgaggcc attgaagtag cagatgagat tattatcact aatgcaggac
     4561 ggatcgaaca gaaaggaact cccatagggg tttacagaaa tcctgagaca gcttttacag
     4621 cgtccttctt cggacagcca tctgtgttga aaaatgcgga tgattttcat acctttgctc
     4681 aggcagaagg agcagacaag atcattgtcc gcccggaatt tgtaaaaatc tccaaactgg
     4741 atgaggtgga gaagttcaaa acttccgtat cccggggagt ggttgaacgg gtttctttca
     4801 ggggagataa tctggaactt caggtgagag tcaataattc cgcagtaatt gccagaagaa
     4861 gcctggagaa agcagatatc cgggaaggtg agactgtgaa tgtattcctt tacaggattt
     4921 ttgcactgag aggtgacagt gtacagctga tcgaaaatga ggctgtaagg gatgactttg
     4981 taattatctg acaacggtgg ctgcggcgac tgacgacaat gaagatggca cattggtatg
     5041 gaggaaaggg taagagagaa tgagaacaga gagaatcagg acagatgtgc tgatcatcgg
     5101 cggcggtacg gcaggatgct ttgcagccta tgtgatcggc aaaaaaagcg gcagaaaagt
     5161 tctgatcgca gagaaagcga atattaagcg aagcggatgt ctggcggcgg gcgtgaatgc
     5221 attgaacgca tatattacag aaggcagagt gccgcaggat tatgtggatt atgccaaaaa
     5281 ggatgcccat ggaatcgtaa gagaagacct tcttcttacc atgtcagaga gactgaatca
     5341 tgtgacaaag gtgatggaag atctggggct ggtcatcctg aaggacgaaa acggaaaata
     5401 tgttgccaga ggaaaccgaa acatcaagat caatggcgaa aatatgaagc caatccttgc
     5461 aaaggcggca gctgaacagg agaatgttac ggttctcaat catgtaaata ttacagatta
     5521 taaaacagaa aacaaaaaag tcacaggcgc agttggattt agcgttaatg aggatatttt
     5581 ctatgacatt gatgcgaaag cagttctttg tgccacaggt ggtgcagcgg gactttacag
     5641 accgaataat ccgggatttt ccagacataa gatgtggtat cctccgttta acacaggtgc
     5701 aggatatgca atgggacttc tttccggtgc ggagatgaca acctttgaga tgcgtttcat
     5761 tgcattgaga tgtaaggaca cgattgctcc tacaggaact attgctcagg gtgttggggc
     5821 cagacaggtc aatgcacatg gtgatattta tgaaacaaaa tatggtctga caacttcccg
     5881 gcgagtttac ggtacagtca tggagaacag agaaggaaac ggtccatgtt atctcagaac
     5941 ggaaggtatt tccaaagaac aggagcagga cctttacaaa gcttacctga atatggcacc
     6001 gtcccagact ctgaaatgga tggaagccgg aaaaggacca tccgaagaga atgtagagat
     6061 tgagggcaca gagccatata ttgtaggcgg acatacagcc agtggttact gggtagataa
     6121 taacagagct acaactattg aaggtttata tgcagccgga gacgtagcgg gaggatgtcc
     6181 gcagaaatat gtaaccggcg cactggcaga aggtgagatc gcagcagagg caattttgga
     6241 atatctgaat ggcaaagatg atgaccggag cgcagcggaa aataaggaag aggctttaga
     6301 gcgtggcgga gaacaggagc tgtctcaaac tgcaatagct aagaaggcag aatacgaatc
     6361 acatttgaat gcttcccgtt ctttgatgaa tgcagagcag cttgaggaag ccatgcagaa
     6421 gatcatggat cagtacgcag gaggaatcag tacagactac agatacagcg ggatgagtct
     6481 tgcaaaggca gatgaaaaga tcgcagcatt gttgccagta gttgacactc tggcagcaac
     6541 agatacttat gaactgatgc agatttatga acttcgcgaa cgactgattg tgtgccgggc
     6601 agtgatcgca catctggcag ccagaaagga aaccagatgg catagtttcg gagagaatac
     6661 agactacccg cagcagagcg aagagtggat gaaatatgta aactcccgta tggaaaacgg
     6721 cgagattaag atcttatatc gtgacctgat tacaaaggaa aatacaggtt tgaatacagc
     6781 agagaaagga gcaggtgaga gatgagcatt cggattcaga aaagtaaatg tgcaggatgc
     6841 ggcagatgta tcgaagcctg tcccggaaat ctaatcaaaa aggataaaga gaacaaagcc
     6901 tttatccgtc aggtaagaga ctgctgggga tgtacttcct gtatcaagga atgcaggcat
     6961 gatgccatcc gctttttcct tggagctgat gtggggggca gaggtgcaag tatggttgta
     7021 tcagagaaac cggatatttc cacatggaca gtggagaagc cggatggcac taagatcact
     7081 attcaggtta ataagaaaga cgctaataaa tattaaacat aagtatgtac tctcagagtc
     7141 tttagagtgt gtttgctcaa gtacgaaaag attccgagta taaacaaaca gaggaggata
     7201 atgcaatgag taacttatct catcttgatg cgcttgaggc agaggcgatt tatattatgc
     7261 gagaagtagc agccgagtgt gaaaagccgg ttatgctcta ttccatagga aaggacagct
     7321 ccgttatgct ccatctggcg atgaaggcat tttacccgga gaaaccgcct tttccctttc
     7381 ttcacattga tactacatgg aaattccatg agatgatcga attccgcgac agaatcgcaa
     7441 aggaaaacgg aattgatatg ctggtttaca ccaatgaaga gggtgtaaag gcaggaatca
     7501 atccatttga caatggttct gcatatacag atatcatgaa aacacaggcg ttaaaacagg
     7561 ctctgaccaa atatggattt acagcggcat ttggaggcgg ccgtcgtgat gaggagaaat
     7621 ccagagcaaa agaaagaatc ttctctttcc gaaattcagc tcaggcatgg gatccgaaaa
     7681 accagagacc ggagatgtgg aagctttata acactaagat ccagaaggga gagagtatgc
     7741 gagtattccc aatttccaac tggacagaaa aggatatctg gcagtacatt cagcgtgaaa
     7801 atatcgaaat tgtaccgtta tattttgcga aagaaagacc ggtcatctac agagacggaa
     7861 atatcattat ggtggatgat gacagattaa aactccgtcc gggtgaaaag attgaaaaca
     7921 aaaaagtcag attccgtact cttggatgct atccgcttac tggaggtatt gaatctgaag
     7981 cagatactct ggatgagatt attgatgaga cattaagtgc tgtttcttct gaacgtacca
     8041 gcagggtgat cgaccacgag gcagcaggca gcatggagag aagaaagaga gaggggtatt
     8101 tctagaatga aaggattatt gaaatttatt acatgcggaa gtgtggatga tggaaaatcc
     8161 actctgatcg gacatattct ttatgatgca aagcttctct atgcagatca ggagaaagcc
     8221 ctggagctgg attccaaagt aggaagcaga ggcggtgcca ttgattattc gcttcttctg
     8281 gacggtctga tggcagagcg tgagcaggga atcaccatcg atgttgcata ccgttatttt
     8341 acaacagata acagaagttt cattgttgca gatacacccg gacatgaaga atatacaaga
     8401 aacatggcag tgggtgcgtc ctttgcagat ctggcagtta tcctggtgga tgcttcacag
     8461 ggcgtactgg tacagacaag acgccatgca agaatctgcg cattgatggg aatccgttac
     8521 tttgtatttg cagtaaacaa aatggatctt attgaatatg atgaaaaacg tttccgcgac
     8581 attgagaatc agatcgcagc actgatagaa gaactgaaac ttgccaatgt aactattatt
     8641 ccggtatctg ccacagaagg tgacaacgtt acaaccaaat ctgacaacat gccatggtat
     8701 aaaggtgagg cacttctttc ccatctggaa accgtagaca ttaaggaaga tacagagaag
     8761 ggcttctata tgcctgtaca gagagtctgc agaccaaacc atgagtttcg cggattccag
     8821 ggacagattg aaaatggtgc catcagggca ggcgaccttg tgactactct tcccagtaaa
     8881 gaagaagctc atgtaaagag cattcttgtt ggcgataaag aagttcagga agctgtacag
     8941 ggacagcctg ttaccatcca gcttgacaga gaagtagatg tttcccgcgg atgtgtactt
     9001 accattgatt ccggcgcagt tcttacagac tctgtggaag cagatatcct ctggatggat
     9061 gacaatgctc ttacggatgg caagaacttc tttgtaaaaa tcggtacaaa gatgatcccc
     9121 ggcctggtta caaagatcaa ttattctgtg gatgttaata caggtgaaaa gaaaagcgca
     9181 tataccttaa agaaaaatga gattgcttcc tgtactctgg aattctcaga gaagatcgtt
     9241 gtagacgaat ttgacaggca cagaacactg ggtgagctga tcctgataga tcgtgtcaca
     9301 aatatgactt ctgcctgcgg tgttgtgaga aaaacttttg tttctcagga taaatcccag
     9361 atcggaaagg tggacgagca ggttcgtgca ggactgaaag gtcagacacc ggtagtagtg
     9421 gaattcccga tcggtaaaga aggaatcact cttgattttg cagaacaggt agaaaaggga
     9481 ctgactgtac ttggaaaaca tacctatctg tatcatccgg cagcgagtga aaactatgca
     9541 gaaactgtcc gccatcttaa ggcagcaggt ctgatcgtac ttcttgttct tgatgaaaat
     9601 acagcaaaag acgagacatt aaagactctg gatggtttct atgcgaactg gcagattgac
     9661 ggaatcactg tgaaagatgc gattgatttc gtgaaaaaga aatctgcatt tacagtgcag
     9721 agtgtacatg atggaaatta tatctgatta taacagggct ataaatcgcc gcagagacaa
     9781 agaaagtctc tgcggtattt tgttttcttg acaagtgtcg ttacagcgga ttatacttat
     9841 tttcaaatat tcagaatcca taataataca gacaggaaag ataacagaaa tatgcaaacg
     9901 aacaatgaaa gtaaacaaaa ccaaaaaaaa gagatgcttc ttggaacttt tctgacaatc
     9961 gtgggaggaa tcctgtgggg gatttccggt gtctgcggtc agttcctgtt tcagaataaa
    10021 gaggtaacag cagcctggct ggttccaata cgtctggtaa cagcaggcct tcttcttctg
    10081 tgctattatt ttttcaaaga taaaggaaaa acatttgata tctggaaaac aaagagaaac
    10141 cggacagata ttattgttta tggtctggcg ggaatgatgt tatgtcagta cagctatttt
    10201 cagactattg aatggtccaa tgccggaaca gctacggtca ttcagtatct cggacctgca
    10261 ctgatcgttg tgtgggtatg ctttcggaca aaacggcttc cccaaaagaa ggaggtgctg
    10321 ggagtttttc ttgcagtaac aggaatcttt ctgattgcaa ctcatggcaa tccaacttct
    10381 ctggcattgt ctcagaaagc tctggccatg gggctgctct cagcagtttc tgtagtggtg
    10441 tatacaataa aacccgcaag actgcaagcg caatttccta caccgctggt tctggcatgg
    10501 ggaatgctga tcggcggagc agtacttatg gcagtatttc gtccatggga ttatcaggtg
    10561 atttttgaca gggaaacatt tgcagcagtt gcctttatta ttttttttgg aactatggcg
    10621 ggattttccc tgtatctgac aggcgtaaag atgataggat ctgtaaaagc cagcctcgtt
    10681 tcctgtgtag aaccggtagc gtctatggtg ctgactgcag tatggatgaa agtcagcttt
    10741 acaacgcctg atctgatcgg aactttgttt gtaattgcta cgatcattat tctggcgata
    10801 ccaacgaaga aaagacagaa ataaagatga gtgaatatcg atcagaatgt agaatgggca
    10861 attggttact gttcacacac cactatcccg cgaggtgttt tggcatgaat atgccaaaat
    10921 cccgagacat acaagctaaa attccattgc cacaggcaat ctggaatgaa ttttggctaa
    10981 gttactgtga acggagtgaa cagtaacggc aatcgtgaag tggcattcag attacatatt
    11041 atgcagcaga gtatgatata atccattttg tataatggcg tcaggattaa gtgcatatgt
    11101 agagctgtgt agcgaagcgg attgcgaata tctgtttgac ttttgatatg taatggggtg
    11161 tacacgagaa caatttttgg aagtgaaagt tatctgtatt atattacaga gggtgttata
    11221 cagataatca ggaggtattt tatgcgtttg gaaaaagtac aggaagcgtt aaaaacaaag
    11281 aaaattcatt atgaatatac agaagaaaac ggatgcggaa gcatcgactt tatgtttcgc
    11341 ggtctgagat ttcatatatg ggaatatgaa gatcgtgtct ggggagcgga gacaaacgtg
    11401 tttgaagcag gcagaagcca ggacattgag ggggattatg aggaaattat ctccggagaa
    11461 atcctctcat ggccggatat gctgcctggg atgtaagcat gttactgttc acagcaacac
    11521 actccaggga gttgagatat gtgaaaagta acgtaagtat tactgcagaa gggaatgata
    11581 tttacgaaaa aatatagaac cggacaaatc gtattaaccg catgtattgc agctgtctgt
    11641 atgttttcag atgtccatgg ggcagaagtg gcaggtccgc cggcaccgaa atccaaatcg
    11701 gcactgacac aaaaacctga agcaacacca atgcctgcat ctactccaac accggagcag
    11761 gaaactgaga cagataaaca gaatccggca gaccagggaa ctttaagcaa gccagaccat
    11821 ctggacacta tctccgcaga taaactggta tttatcggag attctagaac agagggattg
    11881 agggatgcgg taaacgatga cagcatttgg tcctgtcttt cttctatggg atatgactgg
    11941 atggtatcta caggagtgcc gcaggtagaa gatcagattg aggacaatac agcggttatt
    12001 atcctgatgg gtgttaatga tctttatcat gtcaatgact acatcagtta tattaattcc
    12061 aaagctgctg aatgggggaa cagaggagcg cagacttatt tcgtgtctgt aggtccggtg
    12121 cagaatgatc cctattgcag taatgcggag attgaaagtt ttaacgcggc aatgcaggca
    12181 agcctgagtg gagttaccta catagacgta tattcccatc tggtatctga gggattttcc
    12241 accgtagacg gaacccacta tccggacagt gtgtccgtag atatttataa ttatatcctg
    12301 gaccatctgg aggaacagat gagtggaatc tggggataac aacatatgaa cagcaacttc
    12361 gggggcgaca attcagcgaa aattctgatg ttgtgttgag cctggaagca tttggtgata
    12421 tgatatgcag ataaggaaac ggaaatgagc ggaatttcgt ttctctgtga agtggctgaa
    12481 agttcagcag gaggaaaaat gagtgtgctg attgcagcag tgatgaaatt ataaatggaa
    12541 attgttcggt gtccctgcat tggattgccg tacagttatc cgaatcgaaa atcaggagga
    12601 aaaaatgaga ggactgtatt catccaaaac agaaatcaga cacaaaattt ttacagaaat
    12661 tgcgaggatg gcatatgaag gccagtctcc ggagatgctg gaagagcttc cctacaagat
    12721 cgtacccggt gaaattgcga cttatcgtga cagtattttt ctggaaagag cggtagttgg
    12781 tgagagactt cgcgttgcaa tggggatgtc actgagaaag gttacagagc atgcgccaat
    12841 ttccaaaggt gtggaggcca gcgttattga ggaaaagtat tatgaaccgc cgcttatcaa
    12901 tgtgatcaag tttgcctgta attcctgccc tgaaaaaagg gtaatgatca cagagggctg
    12961 tcaggggtgc ctggagcatc cctgtgtgga agtctgtcca aagaaagcag tgcatatgga
    13021 aggcggcaga tcccatattg atgaagatgc ctgtatcaaa tgcggaaagt gtctggaagc
    13081 ctgtccgtat aatgcaatca tcaaacagga acgtccatgt tcaaaggcat gcggtatgaa
    13141 tgctattggc tctgatgaat atggaagagc agagattgat caggataaat gtgtatcctg
    13201 cggacaatgt ctggtaagtt gtccgttcag tgctattgta gacaaaggac agattttcca
    13261 gactattatg gcattaaaaa gtgaaacacc ggtgtatgca atcgtggcgc ctgccattgc
    13321 aggccagttt ccgggtatgg agaataataa gatacgggga gcatttcagg cacttggctt
    13381 tacagatgta agagaggttg ccgtcggtgc agatctgtgc acagtggagg aggcaaagga
    13441 ctttttggaa gaagttcctg agaaacttcc tttcatggct acatcctgtt gtccgtcctg
    13501 gtctatgatg gctaagaaat tattcccgga acaggcgaaa tgtatctcta tggcactgac
    13561 acctatggtt ctcactgcaa ggctgatcaa gcagaaggaa ccagattgta agatcgtttt
    13621 cgtaggtccc tgtgcagcca agaagctgga agccagccgt aagagtatcc gcagctatgt
    13681 ggattttgtg ctgaccttcg aggaagtagc aggaatgttt gatgccaaag gcgtggactg
    13741 gaaagatatt ccggaaggag aaccactgtt tcatgccagt gctgacggaa gaggtttcgc
    13801 agtcagcggt ggtgtggcag aagcggttgt ccatgcggtg aagcgtattg atcctgatcg
    13861 ggaagtaaag gtaatgaatg cagaaggtct gcagaactgt aagaagatgc tccagatggc
    13921 caagattggt aaatataatg gatatctttt ggaaggaatg gcatgtccgg gcggctgtgt
    13981 agcaggtgcc ggtactatcc agacagttaa aaaagcagca gcagctctcg aaaaaatgaa
    14041 gaaagaggct tcgtttacag atgcctatga ctccaaatac agagcaagac tggaaagcct
    14101 ggagaaattt gatgtggagt gagattctga ctgaatcagt gaaatcctat atggattgca
    14161 agtgtttgaa tgcaatcagt atatagcaga gtgaattact cggcaactga gttaccagag
    14221 catctgaatt aaggcgggat accgcctttt ttcagggtgc atccatgaca ccactactgt
    14281 ttgctcttta gagttataca gctactttta ttatttccgg tgttttcagt ccggttacgg
    14341 atagttctct ttttactccg gatacggagt gatattttct caggatatta tatgcgccta
    14401 cggcatctgc gttataggtt ctgtttccat ctctgtacaa ccctctctct ttccgtttgg
    14461 acggctctgc atatcttttc tccactttcg gtgacagcgg actgcactgg ctggtataac
    14521 tttcttcctg ttttataaaa cggatcccat atcttttcag cttatattcc agcatgatgt
    14581 agatcctgtt atacggcagg ctgtgaaact tctggtttgt cctgtgtccc aggtcttttt
    14641 ctctccggat attccggata tcccctgcaa tgacacaggt gatcccctg
//
