LOCUS       c00099_gnlPro..        14654 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GFDDHEID_102.
ACCESSION   c00099_gnlPro..
VERSION     c00099_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 20:42:12
            Original ID  :: gnl|Prokka|GFDDHEID_102
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14654
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14654
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[442:4654](+)"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      443..4654
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     cand_cluster    1..14654
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /kind="single"
                     /product="Others_HGD_unassigned"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14654
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Others_HGD_unassigned"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /tool="gutsmash"
     CDS             443..4654
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg99_1"
                     /sec_met_domain="HGD-D (E-value: 1.7e-22, bitscore: 72.0,
                     seeds: 370, tool: rule-based-clusters)"
                     /sec_met_domain="BcrAD_BadFG (E-value: 1.3e-33, bitscore:
                     108.0, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNVYKVGLDIGSTTTKMVVLDKDGTTVLFSGYKRHQAKIQECLLG
                     FLYQIKEQLGDIPLSFHITGSVGMGISEKCSLPFVQEVVAATNYVCREHPHTATMIDIG
                     GEDAKVVFFQDGQATDLRMNGNCAGGTGAFIDQMAILLGVSIDELNELALRSNQVYSIA
                     SRCGVFCKTDIQNLIAKNISKENIAASIFHAVAVQTTVTLARGCNIVAPVLLCGGPLTF
                     IPALRKAFANYLNLSQDTDFILPEKGNLIPAWGAALAENNEESIHLSNLIQVIENKLSV
                     TSPFQSDLSPIFDSEEEYRSWKKEKDQYKIQYASLRPGLQEATIGIDSGSTTTKIVVLD
                     NNHRILYSYYHDNNGNPIKTVENGLQKLYEECRRRGTTLRIKGGCSTGYGEDLIKAAFH
                     MDAGIIETIAHYAAAKHISKEVSFILDIGGQDMKAIFVNDGVINRIEINEACSSGCGSF
                     ISTFAQSLDYSVEDFAKAACFSQAPCDLGTRCTVFMNSKVKQVLREGASVADIAAGLSY
                     SVVKNCLYKVLQLKDTEILGDHIVVQGGTMRNDSIVRSLEKLTGKQTFRSNCPELMGAL
                     GCALYAKQIENARVTELNEMLQWAQYTSKQLQCRGCENQCAIMRYTFNNDNHYFSGNRC
                     EKVFSNKGSHADKGINTYDKKLELLFDRSADIPQPLFTIGIPRILNMYEEYPFWHTLFT
                     ACGIQVQLSAPSTFSKYETAAGMVMSDNICFPAKLVHSHIRNLTLQNVNRIFMPFVVFE
                     KKDKQQQNSYNCPIVSGYSEVIKSVQEENIPIDAPTITFKDEALLYKQCYEYLKSLGIR
                     DEVCKNAFSRALQEQYAFEEKIAAYNQEVLNEGREKHKLIILLAGRPYHSDPLIQHKVS
                     DMIAAMGVYVITDDIVRQQEISLEKTHYLSQWAFTNRILKATKWAAMQEGDIQYMQMTS
                     FGCGPDAFLIDEVRNLLKRYGKNLTLLKIDDVNNIGSIKLRVRSLVESLNFSLKHSQAK
                     DPEPFVSTAPFTKKDKKKKILAPFFTPFISPLIPSIMKVAGYEMETLPLSDTASCDWGL
                     KYSNNEVCYPATLIVGDIVKAFKSGRYDPANTCVAITQTGGQCRASNYISLIKKALIEN
                     GYTNTPVVSLAFGSGIENEQSGFKVNWLKVLPIILASVLYSDCIAKFYYAAVVREKERG
                     QAARLRDLYLDTAQPIIQKNKPEDLLSYLYLAARDFNKICEQRSCHKVGIVGEIFLKFN
                     PFAQKDVTSWLINQKIEVIPPLISDFFMQGFVNLKVRQNQHLQRKLTPDFVIDWLYKKV
                     QKQINKVNEIGKNFNYFTPFESIFEKAEKAKQVISPGTQFGEGWLISGEILSFASQGVN
                     HVISLQPFGCIANHIVEKGIEKRIKSLCPQMNILSLDFDSSVSDVNITNRLLLFIDNIN
                     N"
     CDS             4659..5279
                     /locus_tag="ctg99_2"
                     /transl_table=11
                     /translation="MATTEHSDLEQQIIKTAQQLFIEKGFVETSMSDIAATVGINRPTL
                     HYYFRTKDKMFKAVFGSIVMSLMPKIQDIVKQDIPFMERLSMILDEYIELFTSNPCLPR
                     FICGEIQRDVNHLLATAKELQFGDALSQVKDSILTAMEDGKLKKVPIHIVFLTVYSLLS
                     YPFLAKNLIVSLFLEDEAAFADFLQEWKQNIINQLQNLLCYEE"
     CDS             complement(5469..5891)
                     /locus_tag="ctg99_3"
                     /transl_table=11
                     /translation="MMRDAEKTVGNMIDKLKTAFIGSIDGEGFPTIKAMLQPRKRKGIK
                     TIYLTTNTSSMRVAQYRENNHACIYFCDTRFFRGVMLRGTMDVLTDSASKEMIWQEGDT
                     MYYPEGVTDPDYCVLKFTAISGRFYSNFKSEDFVVE"
     CDS             complement(5984..6862)
                     /locus_tag="ctg99_4"
                     /transl_table=11
                     /translation="MKNSIPRYTFYKHKYGSELLVDVVELKYVKKFLAKSAVHTLNYYD
                     ITFITEGKGAFSVDNQTYEAIPRDVLFSKPGEIRNWDTHHITNGYALIFEEEFLSFLFK
                     DSLFVQHLSFFQIESSSSLLHLSDELYTRILETLHDIKMEIDSYQQGDVHVLRALLYEV
                     LMLLDRAYLKMTSIEEGRSREVSNNHVSKFMNLVATHAKEQHSVQYYADKLCITPNYLN
                     EMITSTMGISAKQYIQSKVMEEAKRLLVYTDFPIADIAFELCFSTVSYFIRSFRQHTGE
                     TPLLYRKVHKP"
     CDS             complement(6986..7534)
                     /locus_tag="ctg99_5"
                     /transl_table=11
                     /translation="MEAYLKKLCFEYQVDEREVKELLARMEMVYLDKGETIASATLPEQ
                     SLYIIVSGILHTYTTHEGEERTNRFFSAGDAVLCYNSSQYSIKTLTKCAAYYISEEEIE
                     ELCASSISFANLVRQLMEYQFYFKEEEDMNARKLTVRERYLSLLAEIPDILYRVPLKHI
                     NHYLGADVTSLGYLAGSSK"
     CDS             complement(7575..8939)
                     /locus_tag="ctg99_6"
                     /transl_table=11
                     /translation="MKELDLTQGSVPKVLLQFAVPFLIANVLQALYGGADLFVVGQYDD
                     SASVAAVAIGSQVMQTITGIILGITTGTTVLIAIATGAKDNRKVAFTIGSSVWLFSITG
                     VVLTLVMVLFHSRIAELMHTPVEAMVDTKNYILVCSLGILFIVGYNVVCGILRGLGDSK
                     TPLYFVGLACVINIVLDFILVGYFHWGATGAAIATVTAQGVSFGIALWFLYRHGFHFDF
                     SRKDIRLNRNLSKKILVLGAPIALQDALINVSFLIITVIVNQMGVIASASLGVVEKIIV
                     FAMLPPMAISSAVATMTAQNYGAGLIKRMNKCLASGIGIALVFGVSVCVYSQFLPETLT
                     AFFTKDAAVVAMAADYLRGYSIDCIVVSFVFCINSYFSGQGNSLFPMIHSLIATFLFRI
                     PLSYWFSQIDSSSLFIMGFAPPISTVVSLLICIWYLRYTQRKLYLRGTMMPAMSN"
     CDS             complement(9176..10741)
                     /locus_tag="ctg99_7"
                     /transl_table=11
                     /translation="MENESSLLSFRHIYYRGKLNSCNYTCSYCPFGKKSHLADTTQDEQ
                     AWNRFIAAIEQWKGEPLQLFIIPYGEVLIHRYYRKGMVHLAALPQVAGISCQTNLSFPA
                     KHWLDEIRVAPTVISKIRLWASFHPEMTSVEKFAHQIHILHHAGIQVCVGAVGNPSAKA
                     VLNDLRNALLPDIYLFINAMQGLRAPLSQEDIQFFSQLDNLFEYDLKNAPVQWEVCAGG
                     RDNCFIDWKGDMYACPRSRVKIGNFYQGDGAVVPLSCKRKVCDCYIAFSNLNNHPLHRI
                     MGEGAFWRIPDKPLITTVFFDVDGTLTDSQGKVPESYANALRYMAQSVSLYLATSLSME
                     QAKKKLGKALFDLFRGGVFADGGLLSYSRQIKCLPVKVYPEVYGESSKVTIHSYEGVVY
                     KYSILVRDKEQRESILTRLKENPCQVFHKAPLITVIHPEASKKEGMLQLCKALGLASEH
                     TLVVGNSLKDWPMMSVVSHSCAVMNAEPLLKECARYTLNPDRLAAFFRFSNGDPIDQTS
                     SDNS"
     CDS             complement(10753..12030)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Radical_SAM"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg99_8"
                     /sec_met_domain="Radical_SAM (E-value: 2.8e-16, bitscore:
                     51.8, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNQPLPRYVDYMYSYPHKTAYRSFPSPVSLVPYLKQVEGQKASLY
                     FHIPFCSHKCGYCNLFSLQTNRADYIATYLETLHKQAQQLSPLTTGLAFDSFAIGGGTP
                     LLLTVPQLEYLLDTAALFGVHPSHTFTSVETSPEYADPTRLDLLKQAGVARVSIGVQSF
                     LDEELTALKRRPRRDMINQALEAIRKRQFPFFNIDLIYGIRGQTVASFLYSLEQALLFQ
                     PNELFIYPLYVRPGTAITERESDDVCFQMYCAACDLLKDRGFLQTSMRRFIHHPSTDAE
                     ISCGDEVMLSCGSGGRSYLGNLHYATRYTVCQRCIAGEIDDYMGTTDFTVARNGFILSQ
                     EERRQRFIIKNLMYYMGLDKAEYKRRFGESPDNVMLFRQLAERQWIENTDNGRICLTSD
                     GMAYSDYIGQLFITPEIRELMETYSY"
     CDS             complement(12027..12881)
                     /locus_tag="ctg99_9"
                     /transl_table=11
                     /translation="MQIDELPAGEQTQNPDLDMNQVVGTHDILMLCFDTLRYDVSKEEE
                     EAGRTPVLNSHGGEWEKRHAPGNFTYPSHFAIFAGFLPSPAEPHSLRSRKWLFFPVQAG
                     TGRIPPAGSYPFTEATFVQSLANVGYETICIGGVNFFSKRNELGRVFPGYFTKSYWLPT
                     FGCTAPDSTEKQIDFALKKLENYPEDKRIFMYINFSAIHYPNCHYVEGKMKDDKESHAA
                     ALQYVDSQLPRLFQAFQKRGNTLVIALSDHGTCYGEDGYEYHCISHETVYTVPYKHFIL
                     TKK"
     CDS             complement(12868..13878)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg99_10"
                     /sec_met_domain="ATP-grasp_3 (E-value: 8.8e-09, bitscore:
                     27.1, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQIIVVSNSLSKRIEYFIEAGKHLQVEVRFMTYGELFNCLPQLRQ
                     AVIKLEPCVSDETNFLKYALLNQAYKETLQRLGEMRLSDDVCFLNTPHALLRALDKKET
                     KQVLMDRGLKVTPMLPSPRSFDELRELLADCGRGCFLKPRYGSGAGGIMAVRYQPNRNK
                     WVVYTTLQQVDGVIHNTKRINRLSTEKEMIPLAEAVMQTEAILEEWIPKEQLQGENYDL
                     RVVCRESEIDYIVVRCSKGSITNLHLNNKAHWWNELSLPEVVRQQIYFQCQEAVQSLDL
                     QYAGVDVLIERGTDIPYIIEVNGQGDHVYQDMFAHNSIYIQQIKNIKKRYNHANR"
ORIGIN
        1 aggttgtgcc aacgttttga cacaacctca ttttgtttat aattcagctt aaaatctctc
       61 gtctgatcct agaactgttc tacaatagtt tataataaac tcgaataccg ttttactaaa
      121 actatcaaaa agtttattat aaacagaatc cgggtttatt aaaagccacg ttaccttttg
      181 tcaaaaatag agtaaacaag atttctaaga ttcaccataa aagatctact acaacccaac
      241 aagtaatata aatacacaat tattcattta cgtctttttt tacacgatcg ttttcctccc
      301 tcacattcca tctttctttt ttcccaattc gttaattaaa tcaaaaactt caattacgat
      361 ttgccgtatc taccatattt ttacatacat ttgcgtctga cacagatgtc aaacacgagg
      421 tctaatttaa gatatttggt atatgaatgt atataaagtg ggtttagata taggctctac
      481 taccactaag atggtagtat tggataaaga tggaactaca gtcttgtttt ccggatacaa
      541 aaggcatcag gcaaaaatac aagaatgttt actcggattt ctttatcaaa taaaggaaca
      601 gttgggtgat attcctttat ctttccacat tacgggctct gttggaatgg gaatttcaga
      661 gaaatgctct ctgccgtttg tgcaagaggt tgtagctgca acaaactatg tgtgccggga
      721 gcatccgcac acagccacta tgatcgatat tggaggagaa gatgcgaaag ttgttttctt
      781 tcaggacgga caggctacag acctgcgcat gaatggaaat tgcgccggcg gaaccggggc
      841 tttcattgac cagatggcta ttctgcttgg agtctccatc gacgaattga atgaactagc
      901 acttcgttcc aatcaggtat actctatcgc ttcacgctgc ggagtattct gcaaaacgga
      961 catacagaat ctgatagcca aaaatatatc taaagaaaat atagcagctt ccattttcca
     1021 tgcagtagcc gtacagacca ctgtcacact tgcacgcggt tgcaatatcg tagctccggt
     1081 attactctgc ggtggcccat tgacttttat tccggccctt cgaaaagcat ttgccaacta
     1141 tctgaatctg tcacaagata cagatttcat attaccggaa aaaggaaatc tgatccctgc
     1201 ctggggagca gcattggcag agaacaatga agaaagtatt catctctcca acctgataca
     1261 ggtaatagaa aacaaactaa gtgttacctc acctttccag agtgatcttt ctcctatatt
     1321 cgacagtgag gaagaatatc ggtcatggaa aaaagaaaaa gaccagtata aaattcaata
     1381 tgccagtctg cgtcccggat tacaggaagc aactatcggc atagactccg gctctactac
     1441 caccaaaatc gtagtactcg acaacaatca tcgtatcctt tactcctatt atcacgacaa
     1501 caacggaaac cctataaaaa cagtagagaa cggcttgcag aaactatatg aagaatgccg
     1561 gagacgagga actaccctgc gcataaaagg aggatgttct accggttacg gagaagatct
     1621 gataaaagcg gctttccaca tggatgcggg aatcattgaa accatcgctc attatgctgc
     1681 tgccaaacat atcagcaaag aagtttcttt tatcctggat attggagggc aggatatgaa
     1741 agccatcttt gtgaacgacg gagtaatcaa cagaatcgaa atcaatgaag cctgttcctc
     1801 cggttgcggt tcttttatca gcacatttgc gcaatcgctg gattacagtg tggaggactt
     1861 tgccaaagca gcttgttttt cgcaagcacc atgtgatctg ggtacacgtt gcacagtctt
     1921 catgaactcc aaagtaaaac aggtacttcg ggaaggagcg tccgtagcgg atatagctgc
     1981 cggattatct tattccgttg ttaaaaactg cctgtataag gttctgcaat taaaagacac
     2041 ggagatactt ggcgaccata ttgtcgtgca gggaggaacc atgcgtaatg attccatcgt
     2101 acgaagtctg gaaaagctga ccgggaaaca aaccttccgc agtaactgtc ctgaattgat
     2161 gggtgctctt ggttgtgccc tatatgccaa acaaatcgaa aatgcccggg tgacggagct
     2221 gaacgagatg ctccaatggg cgcaatatac ttccaagcaa cttcaatgcc gggggtgcga
     2281 gaaccagtgc gccattatgc gatatacgtt caacaatgac aaccattact tctccggcaa
     2341 ccgatgtgaa aaggtatttt ccaataaagg aagccatgcg gacaaaggca tcaatacgta
     2401 tgataaaaag ctggaattat tattcgaccg gagcgcagac attccacaac ccctatttac
     2461 cataggcatt ccacgtattc tgaatatgta tgaggaatac cctttctggc ataccttatt
     2521 tactgcttgc ggcattcagg tacagttgtc ggccccctct acattcagca aatacgagac
     2581 tgctgccggc atggtgatgt ctgataacat ctgcttccct gccaaacttg tgcacagtca
     2641 tatccgtaac ctgacactgc aaaacgtcaa ccggatattt atgccgttcg ttgttttcga
     2701 gaaaaaggat aagcaacagc aaaacagcta taattgcccc atcgtttccg gttattcgga
     2761 agtcatcaaa agtgtacagg aagagaatat accgatagat gctccgacta tcaccttcaa
     2821 agatgaagca ttgctgtata aacaatgcta tgaatatctg aaatctttgg gtatcaggga
     2881 tgaggtatgc aaaaatgcct tctcacgcgc attacaggaa caatatgctt tcgaagaaaa
     2941 aattgctgcc tataatcagg aagttctgaa cgagggacgg gaaaaacaca aactgattat
     3001 cttactcgcc ggacgccctt accatagcga tccactgata cagcacaagg tttcggacat
     3061 gattgctgcg atgggagttt atgtgataac tgatgatatt gtccgccagc aggagatttc
     3121 attggaaaag actcattacc tctctcaatg ggcatttacc aaccgtattc tgaaagcaac
     3181 caagtgggcg gcaatgcaag agggtgacat acaatatatg cagatgactt cttttggctg
     3241 cggtccggat gctttcctta tagatgaagt acgtaacttg ctgaaacgat acggcaagaa
     3301 tcttactttg ctcaagatag acgatgttaa taatatcggc tccatcaaat tacgagtccg
     3361 ctcgttggtg gaaagcttga atttcagttt gaaacattct caagcgaaag atcccgagcc
     3421 atttgtttca actgctcctt tcaccaagaa agacaaaaag aagaaaatcc tcgctccatt
     3481 ctttacgcct ttcatttcac cactcattcc atccatcatg aaagtggccg gatatgaaat
     3541 ggaaacgtta ccgttgagcg acaccgcatc ttgcgactgg ggattgaaat actccaataa
     3601 tgaggtatgt tatccggcaa cattgattgt cggcgacata gtaaaagcct ttaaaagcgg
     3661 acgttatgat cctgccaata cgtgcgttgc catcacacaa accggtggac aatgtcgtgc
     3721 cagcaactat atttcactga taaaaaaggc attgattgag aatggataca ccaatacacc
     3781 ggtggtatca cttgctttcg gcagtggtat tgaaaatgag caatccggtt ttaaagtaaa
     3841 ctggctcaag gttttgccaa tcatacttgc gtctgtgtta tacagtgatt gtatcgctaa
     3901 attctattat gcagccgtcg ttcgtgagaa agaacgggga caggccgccc gtctgcgcga
     3961 tctttatctg gatacagcac agcccatcat ccagaaaaat aaaccggagg acttgttgag
     4021 ttacttatat ctcgctgcca gagacttcaa caaaatctgt gaacagagat cctgtcacaa
     4081 agtaggtatt gttggagaaa tattcctgaa gttcaaccct tttgctcaaa aggacgtcac
     4141 ctcatggctc atcaaccaga agatcgaagt gattccgcca ctgataagtg atttcttcat
     4201 gcagggattt gtcaacctga aagtgagaca gaaccaacac ttgcagcgaa aactcactcc
     4261 cgactttgtt atcgactggt tatacaagaa agtccagaag cagattaata aagtgaatga
     4321 aatcggcaaa aatttcaatt acttcacgcc gttcgaatca atctttgaaa aggcagaaaa
     4381 agctaaacaa gtcatctccc cgggcaccca gtttggagag ggttggctga tatccggtga
     4441 aatactatcc tttgcttccc aaggagtcaa tcatgtcatt agcttgcaac ctttcggatg
     4501 cattgccaat cacattgtag aaaaaggaat agaaaaacgt ataaaatcgc tgtgccctca
     4561 aatgaatata ctatctttag actttgacag tagcgtcagc gatgtgaaca taacaaacag
     4621 attattactt tttattgaca acataaacaa ctaaaattat ggctacaacg gaacatagcg
     4681 atttagagca gcaaataata aaaactgccc aacaactttt tatagaaaaa ggatttgtgg
     4741 agaccagcat gagtgatatt gctgcaacgg taggaatcaa ccggcccact ttacattatt
     4801 atttcagaac caaagataag atgttcaaag ccgtgttcgg ctcgatagtc atgtctttaa
     4861 tgccgaaaat acaggatata gtaaaacagg atatcccatt tatggagcga ctaagcatga
     4921 ttctggatga gtatattgag cttttcacaa gtaatccctg tcttcccaga ttcatttgcg
     4981 gagaaataca gcgtgatgta aaccacttgc ttgccactgc aaaagaactt cagttcggag
     5041 atgctttatc ccaagtgaaa gacagtatac tgacagcaat ggaagacggt aaacttaaaa
     5101 aggttccgat acatattgta tttctgactg tctacagcct attgagctat ccatttcttg
     5161 ccaagaacct gatagtatct ttattcttgg aagatgaagc cgcttttgct gacttcctgc
     5221 aagaatggaa acaaaacatc atcaaccaat tgcagaactt attgtgttat gaggaatagt
     5281 atagatacta tataaggagg tgtgtcataa tgaataataa aacgcagatt aacgcaaatt
     5341 atcgcagatt attccaatta tattgatata ttaatcaacg acttataaaa ttatttctgc
     5401 gataatttgc gttaatctgc gttttgacac actccgttat taccattcca atcaccccat
     5461 cttgcacctt attcgaccac aaaatcttcc gatttaaaat tactatagaa acgtcctgaa
     5521 atagcagtaa acttcaatac acagtaatcg ggatccgtca ctccctccgg ataatacatg
     5581 gtatctccct cctgccagat catctcttta ctggcactat ccgtcaagac atccatcgta
     5641 ccgcgtagca tgacacctct aaagaatctc gtatcacaga agtagataca cgcatggttg
     5701 ttctcacggt attgcgccac acgcatggac gaagtatttg ttgtcagata aatagttttt
     5761 atcccctttc tttttctggg ttgcagcatt gctttgatgg taggaaatcc ttcaccgtct
     5821 atcgaaccga taaaagctgt tttcagctta tcaatcatgt tgcctactgt tttttccgcg
     5881 tctctcatca ttttactttt tattattggt ttattatctg atgcgaaagt agagaaatgc
     5941 caggaaagca atgcaataaa aagaaaggta gaaatagcac tttttacggt ttgtgtactt
     6001 tacgatacaa taacggagtt tctcccgtat gctgccggaa gctacggata aaataagaaa
     6061 ccgttgaaaa acagagttca aatgcaatat cagctatagg aaagtccgta taaacaagca
     6121 gcctcttagc ctcttccatc accttgctct gaatatattg ttttgcgctg attcccatgg
     6181 tcgaggttat catctcattc agataattag gagtaatgca gagcttatcc gcataatatt
     6241 gaaccgaatg ttgctctttt gcatgtgtag caaccaaatt catgaattta cttacatgat
     6301 tattggaaac ttccctactt ctgccctcct ctatcgaagt cattttaagg taagcacggt
     6361 ccagcaacat caggacttca taaagcaatg ctctcaaaac gtgtacatcg ccctgttgat
     6421 acgaatcaat ctccatcttt atatcatgca aggtttcaag tatgcgtgta taaagctcat
     6481 cagacaaatg tagtagcgat gaagaacttt ctatctgaaa aaacgaaaga tgctgtacaa
     6541 acaaagaatc tttaaagagg aaagacaaaa attcttcttc gaaaatcaga gcatacccat
     6601 tggtgatatg atgagtatcc cagttccgga tttcccccgg tttagagaaa agaacgtcac
     6661 gaggaattgc ttcataggtt tggttatcga ctgaaaaagc tcccttacct tctgttataa
     6721 aagtaatatc ataataattt agagtgtgga cagcactttt agccaggaac ttcttcacat
     6781 acttcagttc tactacatcg accaaaagtt cactcccata cttatgctta taaaaagtat
     6841 atcgaggtat tgagtttttc attcagaata caaaaatagt attccttacc aaataatcca
     6901 aagacttttc aaattcgatt cgattgaata agccatgaac catctgataa ggaatacata
     6961 gaaaaatatg tctaggttat atttcctatt tagaacttcc ggccagatat cccaaactgg
     7021 tcacatctgc ccccaagtaa tgattaatgt gcttcaatgg caccctgtac agaatatccg
     7081 gaatttccgc caataaagag aggtaccttt cccttactgt cagcttgcgg gcattcatat
     7141 cctcttcctc tttaaagtaa aactgatact ccatcagttg acggaccaga ttcgcaaatg
     7201 aaattgaaga tgcacacaac tcttcaatct cctcttcact gatgtaataa gcagcacatt
     7261 tcgtcagtgt cttgatagaa tactgacttg aattatagca taacacagca tcacccgcag
     7321 agaaaaaccg attggttctc tcttctcctt catgagtggt atatgtatgc aaaataccgg
     7381 aaacaataat gtacaagctc tgttctggca atgtggcaga agcaatcgtt tctcctttat
     7441 ccagatacac catttccatt cgagccaaca gctctttcac ttctctttca tccacctgat
     7501 actcaaaaca gagtttcttc aaataagctt ccatacaaaa tagattttag ttaatatatg
     7561 tcacttaaaa acacctaatt cgacatagca ggcatcattg tgcctctcaa atataatttc
     7621 ctttgggtat atcgtaaata ccagatacag atcaataatg aaacgaccgt tgaaatgggt
     7681 ggagcaaatc ccatgataaa cagcgacgag ctatctatct ggctgaacca gtatgacaac
     7741 ggtatacgga acaggaaagt ggctatcaga ctgtgaatca tcgggaataa cgagtttcct
     7801 tgtccgctga aataagaatt aatgcagaac acgaaactaa ccacgatgca gtcgatgcta
     7861 taccctcgca aataatctgc cgccattgcc accacagcag catctttcgt aaagaaagca
     7921 gtaagagtct ccggcaggaa ttgcgaatac acgcaaaccg acacaccgaa aacaagagca
     7981 atcccaatcc ccgaagccag acatttattc attctcttga taagtcccgc tccatagttc
     8041 tgtgcagtca tggttgccac agccgatgat atagccatcg gaggcagcat agcaaacacg
     8101 atgattttct caacaacacc cagggaagca gatgcaatga ctcccatctg attgacaatg
     8161 acagtgataa tcagaaaaga aacattgatt aaagcatcct gcaaagcaat aggtgctccc
     8221 aacaccaaga tctttttaga cagattccgg ttcaatcgaa tatctttccg tgaaaagtca
     8281 aaatggaatc cgtgccggta taagaaccag agcgctattc caaagctgac tccttgtgca
     8341 gttacagtag cgatagccgc tcccgtagcc ccccaatgga aataaccgac caatataaaa
     8401 tcgagcacta tatttatcac acatgccagc ccaacaaaat aaagtggtgt tttagaatca
     8461 cccaatccac gcaaaatacc acatacaaca ttatatccta ctataaacag aatacccaga
     8521 gagcatacca aaatatagtt tttcgtatct accatcgctt cgacaggagt atgcatcagt
     8581 tctgctatcc gactatgaaa aagcaccatg accaaagtta gcactacgcc ggttattgaa
     8641 aacaaccata cggaagaccc gatagtaaaa gctacttttc gattgtcttt agctccggta
     8701 gcaatagcaa tcagcactgt tgtcccggta gtaataccca gaataatacc tgtaattgtc
     8761 tgcatcacct gactaccaat agctacggct gccacacttg ccgaatcatc atattgtccg
     8821 acaacgaaaa ggtcagctcc gccataaagt gcctggagca cattggcaat cagaaaaggt
     8881 actgcaaact gcaacaatac cttcggtacg cttccttgtg tcaaatctaa ctctttcata
     8941 gtttcttcga tacttttcct ctttatctta ttttgttaca acaaaaaaaa gtgccggaca
     9001 agcgaatgat ttgcaccatt catcttatcc agcactataa ttattattat agcaccctcc
     9061 gatgaggatt tttatgcctg tccctatttc agggctgcaa atatgggctt tgttttcata
     9121 attaccaaat tttaaccggt ttttattttc ttatgaagat gtaactagct atatatcaac
     9181 tattatcaga cgaggtttgg tctataggat ctccgttaga aaaacgaaag aaagctgcca
     9241 accgatccgg attcagcgta taacgtgcgc attcttttaa taagggttcc gcattcatta
     9301 cggcacaaga atgagaaacc acggacatca tcggccagtc ctttaacgaa tttcctacaa
     9361 ctaaagtgtg ttcagaagct aaacccaaag ccttacataa ctgaagcatc ccctcttttt
     9421 tactcgcttc aggatgaatg actgttatca gcggagcttt atgaaagacc tggcagggat
     9481 tttctttcaa ccgggtaaga atagattctc tctgttcttt atcacgtacc aatatactat
     9541 acttgtaaac cactccttca taactatgaa tagtaacttt tgacgattct ccatatacct
     9601 ccggatatac tttcaccggc aaacacttaa tctgccgcga ataagataat aaacctccat
     9661 ctgcaaacac tcctcccctg aataaatcaa aaagagcctt tcccagcttt ttcttcgcct
     9721 gctccatcga cagagaagtg gcaagatata aggaaacgga ctgtgccata tatcgcaaag
     9781 cgttagcata actttctgga acttttccct gtgaatcagt cagtgttcca tccacatcga
     9841 agaaaacagt cgtaataagt ggcttgtccg gtattcgcca gaatgcccct tctcccatta
     9901 ttcgatgtaa agggtgattg ttcaggttac taaatgcaat ataacagtca caaaccttcc
     9961 tcttgcaaga taacggcaca acagctccat caccttgata aaaattacct atcttcaccc
    10021 ggcttcgggg acaagcatac atatcccctt tccaatcgat aaaacaatta tcccttcctc
    10081 ctgcgcaaac ttcccattgt accggagcat tcttcaagtc atactcaaaa agattatcca
    10141 gttgactgaa aaactgaata tcttcctgac ttaatggtgc ccttaaccct tgcatagcat
    10201 taatgaataa ataaatatcc ggcaaaagag cattccgtaa atcattgagt acggcctttg
    10261 cagagggatt tcctaccgct ccgacacata cctgtattcc cgcatgatgg agtatatgaa
    10321 tctgatgcgc aaatttctct accgaagtca tctcaggatg aaaactagcc caaagcctta
    10381 tcttacttat cacagtggga gccacacgaa tctcatcaag ccagtgttta gccggaaaag
    10441 aaaggttagt ctgacaggaa attccggcca cctgtggcaa tgccgccaaa tgcaccattc
    10501 ctttccgata ataacgatgg atcaatactt caccgtaagg aataataaat aactgcaacg
    10561 gctccccttt ccattgttca atagctgcta taaaacgatt ccatgcctgt tcatcctgtg
    10621 tcgtatctgc cagatgcgac ttcttgccga aaggacaata agaacaggta tagttgcagc
    10681 tattcaattt gccgcgataa tatatatgcc tgaaggaaag taaagagctt tcgttttcca
    10741 tttctatttc gttcaataag aataagtttc catcagttct cttatttcag gagtaatgaa
    10801 caactgacca atataatcgg agtatgccat tccgtcggaa gtcagacaaa tacgaccgtt
    10861 atccgtattt tctatccatt gccgttcagc taactgtcga aacaacatca cattatccgg
    10921 tgattctcca aagcgacgct tatattcggc cttatcaagc cccatataat acatcagatt
    10981 tttaatgatg aaacgttgtc gccgttcttc ctgagaaaga ataaatccat tacgagccac
    11041 tgtaaaatca gtagtgccca tataatcatc tatctctccg gcaatacaac gctggcaaac
    11101 agtataccgg gtggcataat gcaaattacc caggtaactg cgtccgccgg agccacacga
    11161 cagcatcact tcatccccac atgagatttc cgcatcagta gacggatgat gaataaaacg
    11221 tcgcatcgac gtttgtagaa aacctctgtc tttcaacaaa tcacaagcgg cacaatacat
    11281 ctgaaaacag acatcgtcgg attcccgctc cgtgatagcc gttcccggtc gtacatatag
    11341 cggatagata aagagttcgt taggctgaaa cagaagagcc tgttccaatg aataaagaaa
    11401 gctggccaca gtttgtcctc tgattccgta aatcaaatca atattaaaaa acgggaattg
    11461 tctcttccga atagcctcca gcgcctgatt aatcatgtct cgccggggac gtcttttcaa
    11521 agctgttaat tcttcgtcaa ggaaactctg tacgccaata ctcacacgag ctactcctgc
    11581 ttgcttcaac aagtccaaac gggtaggatc ggcatattcc ggcgatgttt ctacggaagt
    11641 aaaggtatgt gaaggatgca ctccgaataa ggcagccgta tccaataggt attccagttg
    11701 aggaacagtg aggagcaacg gtgtgcctcc tccaatggcg aaactatcaa atgccagtcc
    11761 ggtagtgagt ggagacaact gttgcgcctg cttgtgaaga gtttccaaat aagttgcgat
    11821 ataatccgca cgatttgttt gcagagaaaa caggttgcaa tatccacatt tatgactaca
    11881 aaaaggaata tggaaataaa gcgatgcttt ctgtccttcc acctgtttca ggtaaggaac
    11941 cagcgaaacc ggggacggaa aagaacgata agcagtttta tgtggataac tatacatata
    12001 gtctacatat cgtggtagcg gttgattcat tttttcgtta aaataaagtg tttgtaaggg
    12061 actgtataaa ccgtttcgtg agatatgcaa tgatattcat atccatcctc tccatagcaa
    12121 gtgccatgat cggaaagagc aatcaccagc gtatttcccc gcttctgaaa ggcctgaaat
    12181 aaacggggta gctgactgtc gacatattgc agcgcggcag cgtgtgattc cttatcatcc
    12241 ttcattttgc cttccacata atgacagttc ggataatgaa tagcagaaaa attgatatac
    12301 ataaaaatcc gtttgtcctc cggatagttt tcgagtttct tcaatgcaaa atcaatttgt
    12361 ttttcagtac tatcgggtgc cgtgcatcca aaggtcggca gccaataact tttagtaaag
    12421 taaccgggaa acacacgccc cagttcatta cgcttgctga agaagttcac ccctcctata
    12481 caaatcgttt catagcctac attggcaagg ctttgcacaa aagttgcttc cgtaaacgga
    12541 taacttcccg caggcggaat acgtcccgta ccagcttgca cagggaaaaa caaccactta
    12601 cggctgcgta gcgaatgagg ttccgccgga gaaggcagaa atcctgcaaa gatggcaaaa
    12661 tgagacgggt aagtaaaatt tcccggcgca tgtctttttt cccattctcc tccgtgactg
    12721 ttcagtaccg gtgttcttcc tgcctcttct tcctccttgc tgacatcata acgcaaggta
    12781 tcaaagcaaa gcatcaatat atcatgagta cccaccacct gattcatatc cagatccgga
    12841 ttttgggtct gttcgccagc cggcagttca tctatttgca tggttatatc tcttttttat
    12901 gttttttatc tgttgaatat aaatagaatt atgagcaaac atatcctgat acacatgatc
    12961 tccctgtccg ttgacttcta ttatataagg aatatctgtt cctctctcta tcagtacatc
    13021 cactccggca tattgcaaat ccaaagattg aaccgcttcc tgacactgaa aatagatttg
    13081 ttgccgcact acttccggca aagacaattc gttccaccaa tgtgccttat tgttcagatg
    13141 cagattggtt atgcttcctt tactgcatct cacaacgata taatcaattt cagattcccg
    13201 gcacactaca cgaagatcat aattctctcc ctgcaactgc tctttaggaa tccattcttc
    13261 taaaatagct tctgtttgca tcacagcttc cgccaacggg atcatctctt tttccgtact
    13321 caaacggttg atacgtttag tgttatgaat gactccatcc acttgttgca aggtagtata
    13381 gactacccat ttattccggt tgggttgata gcgaacagcc ataatacctc ccgcccccga
    13441 accgtaacgg ggtttcaaaa agcatcctct accgcaatcg gcaagaagct ctctcaactc
    13501 atcaaaagaa cggggagaag gtaacatcgg agtcactttc aaccctctgt ccatcaacac
    13561 ttgtttagtt tcctttttat caagagcacg taataaagca tggggagtat tcaaaaagca
    13621 cacgtcatca gatagcctca tctcgcctaa acgttgcagt gtctccttat atgcctgatt
    13681 caacagcgca tatttcagga aattcgtttc atcgcttaca caaggttcca gtttgataac
    13741 tgcctgccgt agttgcggca agcagttaaa aagttccccg taagtcataa aacgaacttc
    13801 cacctgcaag tgtttgcctg cttcaataaa gtattctata cgtttggaca gagagttgct
    13861 gacaacgatt atctgcatct cctattctgt aatcatcggg taataccaca attcaccatc
    13921 atattcatct gcctcttcag tttcagcaat atctattttc atagggagac tctgcaactg
    13981 tttcttcatc tccttgctca aataattata gcgcatattg ataaacttca aatgagcgat
    14041 cttatccata ttatccagca ataattgggc accttcatct ttgagagtac cagccgaaac
    14101 atccattgtt tcaagttggg gaagaatatc cgactccagg aacatttcta caatcttgtc
    14161 ctgttcttca gagttgacga tccccagata agtcagcttc gggaaacgtt ctttggagaa
    14221 caacggacgg aatatctcaa tatcagcttc aaatccataa tcttccacac caacatatag
    14281 aatcagtttt tccagattgg ggaaatcaga accaagaata tcttctacca cttcggtagg
    14341 caggccacca ctgataattt cgagtgaccg caactccggc cgtgaagtct ttcccaaacg
    14401 cagattattg gttcctttga ttttcagatc tttcaattta ggcatggcat cgagcagcgg
    14461 actaatatca gcttgttcaa tccatgaaat ctcctgttct tcctgctcaa tatctcccca
    14521 gaacaagcct tctatttgtg cgaacttctc cttattttca atcattccct gtaataaggc
    14581 agaacagtcg ccaccctcat aatcccaaca accgattgtt atttgtttat attcagagag
    14641 atgtttatct ttca
//
