LOCUS       c00169_gnlPro..        15434 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GFDDHEID_182.
ACCESSION   c00169_gnlPro..
VERSION     c00169_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 20:42:12
            Original ID  :: gnl|Prokka|GFDDHEID_182
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15434
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15434
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1885:5434](+)"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1886..5434
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
     cand_cluster    1..15434
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /kind="single"
                     /product="PFOR_II_pathway"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15434
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="PFOR_II_pathway"
                     /region_number="1"
                     /rules="cds(POR and POR_N and PFOR_II and EKR and Fer4_16
                     and TPP_enzyme_C)"
                     /tool="gutsmash"
     CDS             complement(3..527)
                     /locus_tag="ctg169_1"
                     /transl_table=11
                     /translation="LNSFEMTKKALYIFNPEHDLALASGETNYMAPASARRMASELALL
                     PMWYAEEGSAVLAPSAYNLGYVKKIQELLGLSVDLMTEPELAIEPNLDIRPWGWDVALR
                     KRLSGLGMDEALLPSMEQLDGLREYSHRSKAVSLLPELQLNEYFCGESYYLKTQEEWKT
                     FVEERECCLLKA"
     CDS             675..1853
                     /locus_tag="ctg169_2"
                     /transl_table=11
                     /translation="MESFYRTHAYLVEHTNAPVRRDLMDEIDWSDRLIGIKGTRGVGKT
                     TFLLQYAKEKFGNDRSCLFINMNNFYFSGHSIVDFANEFQKRGGKVLLIDQVFKHPEWS
                     KELRMCYDRFPNLKIVFTGSSVMRLKEENLELRDIAKSYNLRGFSFREFLNLQTGMKFR
                     AYSLEEILSTHEQIAKGVLSKVRPLDYFQDYLHHGFYPFFLEKRNFSENLLKTMNMMVE
                     VDILLIKQIELKYLSKIKKLLYLLAVDGPKAPNVSQLASDIQTSRATVMNYIKYLADAR
                     LINLVYPKGEEFPKKPSKIMMHNSNLMYSIYPVKVEEQDVLDTFFANSLWKDHKVHKGD
                     KNVSFMVDEVMPFKICQEGAKIKNNPNVTYALHKAEIGRGNQIPLWMFGFLY"
     CDS             1886..5434
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: Fer4_16"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: PFOR_II"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: EKR"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg169_3"
                     /sec_met_domain="PFOR_II (E-value: 3.4e-18, bitscore: 57.9,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="POR_N (E-value: 1.6e-82, bitscore: 268.6,
                     seeds: 31, tool: rule-based-clusters)"
                     /sec_met_domain="POR (E-value: 3.5e-31, bitscore: 100.6,
                     seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 7.6e-12, bitscore:
                     37.3, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_16 (E-value: 1.4e-11, bitscore: 37.2,
                     seeds: 227, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 2.5e-07, bitscore: 22.4,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 0.00014, bitscore: 14.4,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="EKR (E-value: 8.5e-25, bitscore: 78.4,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKQKKFITCDGNQAAAHISYMFSEVAAIYPITPSSTMAEYVDEW
                     AAAGRKNIFGETVLVQEMQSEGGAAGAVHGSLQAGALTTTYTASQGLLLMIPNMYKIAG
                     EFLPCVFHVSARTLASHALCIFGDHQDVMSARQTGFAMLAEGSVQEVMDLAGVAHLATI
                     KSRVPFMNFFDGFRTSHEIQKIEMLENDDLAPLIDQKALAEFRARALNPMKPVARGMAE
                     NPDHFFQHRESCNNYYEAVPAIVEEYMNEISKITGRKYGLFDYYGAEDAERVIIAMGSV
                     TEAAREAIDYLVANGEKVGMVAVHLYRPFSAKHFLAAVPKTAKTIAVLDRTKEPGANGE
                     PLYLDVKDCFYGAENAPVIVGGRYGLGSKDTTPAQILSVFENLAMPMPKNHFTIGIVDD
                     VTFTSLPQKEEIALGGEGMFEAKFYGLGADGTVGANKNSVKIIGDNTDKHCQAYFSYDS
                     KKSGGFTCSHLRFGDNPIRSTYLVNTPNFVACHVQAYLHMYDVTRGLRKNGSFLLNTIW
                     EGEELAKNLPNKVKKYFAQNNISVYYINATQIALEIGLGNRTNTILQSAFFRITGVIPV
                     EQAVEQMKKFIVKSYGKKGEDVVNKNYAAVDRGGEYKTLAVDPAWANLPDDAKAENNDP
                     AFINEVVRPINAQDGDLLPVSAFKGIEDGTWYQGTAKYEKRGVAAFVPEWNAENCIQCN
                     KCAYVCPHASIRPFVLDAEEQKGAKFEQLKAVGKAFDGMTFRIQVDVLDCLGCGNCADI
                     CPGNPKKGGKALTMKHLESQLAQAENWTYCAENVKTKQHLVDIKANVKNSQFATPLFEF
                     SGACSGCGETPYVKLISQLFGDREMVANATGCSSIYSGSVPSTPYTTNENGHGPAWANS
                     LFEDFCEFGLGMELANEKMRARLVKVMNEAIAADCTPAEVKELFAEWINNMLDADKTKE
                     LAAKIIPVVEANKDKCNHCKQIAELQQYLVKRSQWIIGGDGASYDIGYGGLDHVIASGK
                     DVNILVLDTEVYSNTGGQSSKATPVGAIAKFAAAGKRVRKKDLGLMATTYGYVYVAQIA
                     MGADQAQTLKAIREAEAYPGPSLIIAYAPCINHGLKAGMGKSQEEEEKAVKCGYWHLWR
                     YNPALEEEGKNPFQLDSKEPNWEDFQGFLKGEVRYASVMKQYPAEAEELFKAAEENAKW
                     RYNSYKRLARENWGAE"
     CDS             complement(5445..5546)
                     /locus_tag="ctg169_4"
                     /transl_table=11
                     /translation="MNSSGKKGVLFMLDRVHTIKKTVIFYKITVLYL"
     CDS             complement(5588..6454)
                     /locus_tag="ctg169_5"
                     /transl_table=11
                     /translation="MRIYKIVGIVLSAMLLLASCTNSGLEKKKVKIAYANWLEGIAMSH
                     LAKVVLEEHGYEVELQNADLAPIFVSMSGKKSDVFLDAWLPITMKDYMDQYGDSIEFLG
                     EVYGEARVGLVVPQYVTIQSISELEANKDRFSSEIVGIDAGAGIMKTTDKAIAAYGLDG
                     YTLMTSSSSTMLASLKKAMDKGEWIVITGWTPHWMFDQFDLKFLDDPKKVYGDLEEIHA
                     IAWKGFSEKDPFAAEFFGNIKLTTEELSSFMTAMKDARMDEEEIARKWRDEHRQLVDSW
                     IPKSENK"
     CDS             complement(6475..7299)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 92.5; E-value: 8.7e-29)"
                     /gene_kind="transport"
                     /locus_tag="ctg169_6"
                     /sec_met_domain="BPD_transp_1 (E-value: 8.6e-29, bitscore:
                     92.5, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINIGQYIETVINWMMVHFSTFFDAINAGIGSFIIGFQHVLFGIP
                     FYITILVLAALAWMKAGRGTAIFTALGLLLIYGMGFWEATMQTLALVFSSTCLALIVGV
                     PLGVWTANSPRAEKILRPVLDLMQTMPAFVYLIPAVLFFGLGAVPGVFATIIFAMPPVV
                     RLTGLGIRQVPKNVVEASRSFGATRWQLLYKVQLPLALPTILTGVNQTIMMSLSMVVIA
                     AMIAAGGLGEIVLKGITQMKIGLGFEGGIAVVILAIILDRITQGMAGRKNKN"
     CDS             complement(7296..8522)
                     /locus_tag="ctg169_7"
                     /transl_table=11
                     /translation="MSKIEIKDLYLIFGNEKQKALKMLKKDKSKEEILKDTGCTVGVKD
                     ANLSINEGEFFVIMGLSGSGKSTLLRCINRLIRPTTGQVLVNGVDISKISEKELLQVRR
                     KELAMVFQNFGLLPHRSVLSNIAFGLELQGVKKEEREKKAMESMKLVGLKGYENQMVGE
                     LSGGMQQRVGLARALANNPEVLLMDEAFSALDPLIRVQMQDELLALQSKMKKTIVFITH
                     DLSEAIKLGDRIAIMKDGEVVQVGTSEEILTEPANDYVARFVENVDRSKIITASSLMID
                     KPLVARLKKEGPEVLIRKMRAKNITVLPVIDADDKLVGEVRLNDLLKLRSRQEKSIETI
                     VRTEVHSVLEDTVLEDILPLMTKSNSPVWVIDETHEFLGTIPLSSLIIEVTGKDKEEIN
                     EIIQNAIDL"
     CDS             complement(8822..9160)
                     /locus_tag="ctg169_8"
                     /transl_table=11
                     /translation="MKDYKVDKASLSASFCQEVYQVVREIPVGKVSTYGGIAALLGMSQ
                     CFRMVGRALKQIPDDLSAPCHRVVNASGRLVPGWTEQKQLLLEEGISFKQNGCVDLKKH
                     LWNYSVPE"
     CDS             9244..10539
                     /locus_tag="ctg169_9"
                     /transl_table=11
                     /translation="MQLYLLYLQIIPTFVPIKSNPIINKTSTAVMKKKTILFASCLLGA
                     LAFSSCEKNLYDESKQPEKEKKMTDLEVPADFDWKGSQNAKVKIASQSTATISVFLEEN
                     CNEEALMLRMDVDANTSKLELPIEIPAYIKNVYVKYGNGSEIQTVPVESNGTISIVVPA
                     NATALSRVTTRANKEVETNNIFNYPGYGNGTIMFEDMYPALGDYDFNDFVAWYNFQIDG
                     FYWSHNQCYAEYLMIGFQIRAIGGIYDYNPYIRLAEVQYNELDLEETQMYLERNNPEEA
                     ENIKILKGPKGELIISLKKPAIPNGYKYYNTEVNEKTKPKKMMAIYLVFNSPVNVKSLQ
                     DSKMDFYIAKTNKGQEIHLKGYSPVYYNSNESYVNEDNFIWGLKVPASLHHAREEVNFL
                     EAYPDFEQWVTSGGQENQRWWNKPKTNKLIMN"
     CDS             complement(10681..13428)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peripla_BP_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:Periplasmic binding proteins and sugar binding
                     domain of LacI family (Score: 61.6; E-value: 2.6e-19)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg169_10"
                     /sec_met_domain="Peripla_BP_1 (E-value: 2.6e-19, bitscore:
                     61.6, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNDEILREAMFYDGVSVEIRSAADDNRKQAEDVHYFIDKGVDLLI
                     ISANEAAPMTPIVEEAYQKGIPVILVDRKILSDKYTAYIGADNYEIGRAVGNYIASSLK
                     GKGNVVELTGLSGSTPAMERHQGFMAAISNYPDIKLIDKADAAWEREPAEVEMDSMLRR
                     HPKIDAVYAHNDRIAPGAYQAAKKAGREKEMIFVGIDALPGKGNGLELVLDNVLDATFI
                     YPTNGDKVMQLAMNILEKKSYPRETVMNTAVVDRTNAHVMQLQTTHISELDQKIETLNG
                     RIGGYLSRVATQQVVMYGGLVILLLVAGLLLVVYKSLRSKNRLNKELSEQKKQVEQQRD
                     KLEEQRDILEEQRDKLEEQRDQLIQLSHQLEEATHAKLVFFTNISHDFRTPLTLVADPV
                     EHLLADSSLSEDQRRMLLLVQRNVNILLRLVNQILDFRKYENGKMEYTPISLDILSSFE
                     GWNESFMAAARKKHIHFSFDYMPDTDYRTLADVEKLERIYFNLLSNAFKFTPENGKVTV
                     RLSSLTKDDHCWIRFTVANTGSMISAEHIRNIFDRFYKIDMHHAGSGIGLALVKAFVEL
                     HKGTITVESDEKQGTIFTVDLPVQTCETVVSENSPAFSVPATSVTSTDAATSAVAGAPV
                     TPATSGYSGSSSLNDALTYEEEELEKSYDSSKPCVLIIDDNADIRLYVHGLLHTDYTVI
                     EAAYGSEGIRKAMKYVPDLIISDVMMPGMDGIECCRRLKSELQTCHIPVILLTACSLDE
                     QRIQGYDGGADSYISKPFSSQLLLARVRNLIDSHRRLKQFFGDGQTLAKEDVCDMDKDF
                     VEKFKALIEAKMGDSNLNVEDLGKDMGLSRVQLYRKIKSLTNYSPNELLRIARLKKAAS
                     LLASSDMTVAEIGYEVGFSSPSYFTKCYREQFGESPTDLLKRKG"
ORIGIN
        1 ggagctttca acaggcagca ttcccgttct tccacaaagg ttttccattc ttcttgtgtc
       61 ttcaaataat aagattctcc gcagaaatat tcattcagtt gtaattccgg aagcaatgag
      121 acggctttag aacgatggga gtattcccgc aaaccgtcta attgctccat agaaggaagc
      181 agggcttcat ccatgcccag ccctgaaagc cgtttccgca aagctacatc ccatccccaa
      241 ggacgaatat ccaaattcgg ttcaatagca agttccggct ctgtcatcaa atcaaccgaa
      301 agtcctaata attcctgtat cttcttcaca tagccgagat tataagcgga aggagctaat
      361 acagcactcc cctcctctgc ataccacatc ggaagcaaag ccaactcgga agccatacgt
      421 ctggcagaag ccggagccat ataatttgtt tcaccgctag ccaacgccaa gtcatgttcc
      481 ggattgaata tataaagagc cttttttgtc atttcaaatg aattcaaaac tttattctgc
      541 aaatatatac aggaaatagt caggaatgac tacaataaac agaaagttgg aattaaacac
      601 acaattttgc catctctact ttgcaaatcc taaaaaaagc agtatatttg ccacccgaaa
      661 aacaaagaac tgaaatggaa tcattctacc gcacacacgc ctacctcgtt gagcacacca
      721 atgcccccgt tcgccgcgat cttatggacg agatcgactg gagcgaccgc ctgattggta
      781 tcaaagggac acgtggcgta ggaaaaacca ctttccttct ccaatacgcc aaagagaaat
      841 tcgggaacga ccgttcctgt ctgttcatca acatgaacaa cttctatttc tcgggccaca
      901 gcattgtaga cttcgccaac gaatttcaga aacgtggcgg aaaagtattg ttgatcgacc
      961 aggtgttcaa acatcctgaa tggagcaaag agttacgcat gtgttacgac cgttttccta
     1021 acctgaaaat tgtcttcacc ggctcgtccg tgatgcgact gaaagaagaa aatcttgaat
     1081 tacgtgatat cgccaagagc tataacctgc gtggattctc tttccgtgaa ttcttaaact
     1141 tgcaaacagg catgaaattc agggcatata gcctcgaaga aattcttagc actcacgaac
     1201 agattgccaa aggagtactc tccaaagttc gtccgttgga ctattttcag gattacctgc
     1261 accacggatt ctatccgttc ttccttgaaa aacgtaactt ttcggagaat ctgctgaaaa
     1321 cgatgaacat gatggtggaa gtagatatac ttctcatcaa acaaattgaa ctgaaatatc
     1381 tttcaaagat aaaaaaattg ctatatttgc tcgctgtcga tgggccgaag gctccaaatg
     1441 tgagccaact ggcaagcgac atacagacat ctcgcgccac ggtgatgaac tatatcaagt
     1501 atctggcaga tgcgcgactc attaatctgg tttatccgaa aggggaagaa ttccctaaaa
     1561 aaccttcgaa gataatgatg cacaactcca acctgatgta ttccatctat ccggtgaaag
     1621 tggaagagca agatgtgctc gacacattct ttgcaaattc tttatggaaa gaccataagg
     1681 tacataaagg agataaaaac gtctctttta tggtagacga agtaatgccg ttcaaaattt
     1741 gccaggaagg cgcaaagatc aagaacaatc cgaatgtaac gtacgcgttg cataaggctg
     1801 aaataggtcg gggcaaccag atacctctct ggatgttcgg ctttttatat taaaagattt
     1861 atttacttaa atatttaatt tagttatgac taaacagaag aaattcatca cttgtgatgg
     1921 taaccaggct gcagcgcata tctcgtatat gttctctgaa gtagcagcta tctaccccat
     1981 cactccttct tcgactatgg ctgagtacgt agacgaatgg gctgccgcag gacgtaagaa
     2041 catcttcggc gaaacagtat tagtacagga aatgcaatct gaaggtggtg ctgccggtgc
     2101 agttcacggt tctcttcagg ctggtgcgtt gactactact tacactgctt cccaggggct
     2161 tctcctgatg atccctaaca tgtacaaaat tgccggtgag ttcttgcctt gcgtattcca
     2221 tgtatctgct cgtacattgg cttctcacgc attgtgtatc ttcggtgacc accaagacgt
     2281 aatgtcagct cgtcagactg gctttgctat gttggctgaa ggctctgtac aggaagttat
     2341 ggatttggct ggtgttgctc acttggctac catcaaatct cgcgttccgt tcatgaactt
     2401 cttcgatggt ttccgtacat ctcacgaaat ccaaaagatt gaaatgttgg aaaatgatga
     2461 tcttgctccg ctgatcgacc agaaagcttt ggctgaattc cgtgcccgcg cactgaaccc
     2521 gatgaaaccg gtagctcgtg gtatggctga aaatcctgac catttcttcc aacatcgtga
     2581 atcatgcaac aactactatg aagcagttcc tgctatcgta gaagaataca tgaatgaaat
     2641 ttctaagatc acaggtcgta aatacggttt gttcgattac tatggtgcag aagatgcaga
     2701 acgcgtaatt atcgctatgg gttctgtaac agaagctgcc cgcgaagcta tcgactacct
     2761 ggtagcaaac ggcgaaaaag tgggtatggt tgccgtacac ctgtatcgtc cgttctctgc
     2821 taaacacttc ttggctgctg tacctaagac tgctaaaact atcgcagttc ttgaccgtac
     2881 taaagaaccg ggtgctaacg gcgaacctct ttaccttgac gttaaagact gcttctacgg
     2941 tgcagaaaat gctccggtta tcgttggcgg tcgctacggt ttgggttcaa aagatactac
     3001 tcctgctcaa atcctttcag tattcgaaaa cttggctatg ccaatgccga agaaccactt
     3061 cactatcggt atcgtagacg acgttacttt cacttctctt cctcaaaaag aagaaatcgc
     3121 tttaggcggc gaaggtatgt tcgaagctaa attctacggt ttgggtgctg acggtacagt
     3181 aggtgctaac aagaactctg taaagattat cggtgataac actgacaaac actgccaggc
     3241 ttacttctct tatgactcta agaagtcagg tggcttcact tgttctcact tgcgtttcgg
     3301 tgataatccg atccgttcta cttatttggt aaacactccg aacttcgttg cttgtcacgt
     3361 tcaggcttac ctgcacatgt acgatgtaac tcgtggtttg cgtaagaacg gttctttctt
     3421 attgaacaca atctgggaag gtgaagaact ggctaagaac ctgcctaaca aggttaagaa
     3481 atatttcgca cagaacaaca tttctgtata ctatatcaac gcaacacaga ttgcactgga
     3541 aattggtttg ggtaaccgta ccaacacaat ccttcaatct gcattcttcc gtatcacagg
     3601 cgttattcct gtagaacaag ctgttgagca gatgaagaaa ttcatcgtta aatcttacgg
     3661 caagaagggt gaagacgttg ttaacaagaa ctatgctgcc gttgaccgtg gtggtgaata
     3721 caagactttg gctgttgatc ctgcttgggc taacctgccg gatgacgcaa aagctgaaaa
     3781 caacgatcct gcattcatca acgaagtagt tcgtccgatc aatgcacaag acggtgactt
     3841 gttgccggta tctgcattca agggtatcga agacggtact tggtatcaag gtactgctaa
     3901 atacgaaaaa cgtggtgtag ctgcattcgt tcctgaatgg aatgctgaaa actgtatcca
     3961 gtgtaacaag tgtgcatacg tttgtcctca cgcttctatc cgtccgttcg tactcgacgc
     4021 tgaagagcag aagggtgcta agttcgaaca actgaaagct gtaggtaaag cattcgacgg
     4081 tatgacattc cgtatccagg tggacgttct cgactgtctg ggttgcggta actgtgccga
     4141 catctgtccg ggtaatccga agaagggtgg aaaagcattg acaatgaaac acctcgaaag
     4201 ccaattggct caagctgaaa actggactta ctgtgctgaa aacgtgaaga ctaaacaaca
     4261 tcttgttgat atcaaggcta acgtgaagaa ctcacagttc gctactccgt tgtttgagtt
     4321 ctccggcgct tgctctggtt gtggtgaaac tccatacgtg aaattgattt ctcaattgtt
     4381 cggtgaccgt gaaatggttg ctaacgctac cggatgttct tctatctact ctggttctgt
     4441 tccttctact ccgtatacta caaacgaaaa cggacacggt cctgcttggg ctaactcact
     4501 gttcgaagac ttctgtgaat tcggtttggg tatggaactg gctaacgaaa agatgcgtgc
     4561 tcgtctcgtg aaagtgatga acgaggctat tgctgctgat tgcactcctg ctgaagtaaa
     4621 agaactgttc gctgaatgga tcaacaatat gctggatgcg gacaagacta aggaattggc
     4681 tgctaagatc attccggttg ttgaagctaa caaggataaa tgtaaccact gcaaacaaat
     4741 cgctgaactg caacaatatc ttgtaaaacg cagccagtgg atcattggtg gtgacggtgc
     4801 ttcttacgat atcggttacg gtggtcttga ccatgtaatc gcttccggta aggacgttaa
     4861 catcctcgtt ctggatactg aagtttactc taacacaggt ggtcagtctt ctaaagctac
     4921 tccggtaggt gctatcgcta agttcgctgc tgctggtaag cgcgtacgta agaaagacct
     4981 cggtctgatg gctactactt acggttatgt atatgttgca cagatcgcta tgggtgctga
     5041 ccaagctcaa actctgaaag ctatccgtga agctgaagca tatccgggac catctttgat
     5101 tatcgcttac gctccatgta tcaaccacgg tctgaaagca ggtatgggta agagccagga
     5161 agaagaagaa aaagctgtta agtgcggtta ctggcacttg tggcgttaca acccggcttt
     5221 ggaagaagaa ggcaagaacc cattccaatt ggatagcaaa gaaccgaact gggaagattt
     5281 ccaaggtttc ttgaagggtg aagttcgtta cgcttctgta atgaaacaat atcctgctga
     5341 agctgaagaa ctgtttaaag ctgctgaaga aaacgctaaa tggcgttaca acagctacaa
     5401 acgtttggct agagaaaact ggggtgctga ataatagtaa taccctataa atataaaacg
     5461 gtaatcttgt agaagattac cgtttttttt attgtatgaa ctctgtctaa cataaacaat
     5521 actccctttt tcccactaga gttcatgtct attttatatt taaaattaag aataacaatg
     5581 ctccaatcta tttattctca gacttcggaa tccaactatc caccaactgc cgatgttcat
     5641 ccctccattt gcgggctatt tcttcttcat ccatccgggc atccttcata gctgtcataa
     5701 aagagctaag ttcttctgtc gttagtttaa tgttgccaaa gaattcggca gcaaacggat
     5761 ctttctcact gaatcctttc catgcaatag catgtatttc ttccaagtct ccatatactt
     5821 tcttcggatc atccaagaat ttcaagtcaa actggtcgaa catccaatgc ggtgtccacc
     5881 ccgtaatgac aatccattct cctttgtcca tcgctttttt caaagaagcc agcatggtgg
     5941 aactacttga agtcatgagg gtatacccat caagtccgta agcagcaatg gccttatcgg
     6001 tcgtcttcat tatccctgct cccgcatcaa ttcctactat ttcagaagag aaacggtctt
     6061 tattagcttc cagctcacta atagactgga tcgtaacata ttgaggaaca accagtccta
     6121 cacgggcttc tccatatacc tcccccaaaa attcgatgct gtctccatac tgatccatat
     6181 aatctttcat cgttattggt aaccatgcat ccagaaagac atcagatttc tttcctgaca
     6241 tagatacaaa aataggggca agatcagcat tttgcaattc aacctcatat ccatgctctt
     6301 ccaataccac cttggccaaa tgactcatgg caataccttc cagccaattg gcataggcta
     6361 tttttacttt ctttttctct aagcctgaat tagtacagga agctagcaaa agcatagctg
     6421 acaatactat tcctactatt ttatatattc tcatacgtat tttatccttt ccgtttagtt
     6481 cttatttttt cgtcctgcca ttccttgtgt gatacggtct aagataatag ctaaaataac
     6541 aactgctata ccaccttcaa acccaagtcc gattttcatt tgggtaatac ctttcaatac
     6601 aatttctccc agaccaccgg cagcaatcat ggcagcaatg acaaccatag aaagcgacat
     6661 cattattgtc tggttgacac cagtcaggat agtgggcaac gccaaaggaa gctgcacttt
     6721 atacaataac tgccaacggg tagctccgaa cgaacgggaa gcttccacta catttttagg
     6781 aacttgccgt attcccaatc cggtaaggcg gaccacagga ggcatagcaa agataatggt
     6841 ggcaaacact cctggcactg ctcccaatcc gaaaaataaa acggcaggaa tcagataaac
     6901 aaaagcaggc atcgtctgca tcaagtcgag aacaggacga agtattttct ctgcacgcgg
     6961 actgtttgcc gtccacactc ctaaaggtac accaacaatc agggccagac aggtagatga
     7021 aaaaacaaga gccagggttt gcatagtagc ctcccaaaat cccattccat aaatcagtaa
     7081 taatcccaat gcggtgaaaa ttgccgtacc acgtcctgcc ttcatccatg cgagtgcagc
     7141 aagcactaga atggttatat aaaaaggtat tccaaaaagt acgtgttgga atcctataat
     7201 aaaactaccg atgcctgcat ttatggcatc aaagaaagtg gaaaaatgta ccatcatcca
     7261 attgatgacc gtctctatat attgtcctat atttatcata aatctattgc gttttgaatt
     7321 atttcgttta tttcttcttt atctttcccc gtcacttcga tgattaagga ggaaagcggg
     7381 attgttccta aaaactcatg cgtctcatca atcacccata ccggcgaatt gctctttgtc
     7441 attaaaggaa gtatatcctc caacactgta tcctccaata cagaatgtac ttcggtacgc
     7501 acaatcgttt caatggattt ttcctgtctg ctacgtaact taagcaggtc gttcagacgt
     7561 acttctccga ccagtttatc atcggcgtct atgacaggta atacggtgat attcttcgca
     7621 cgcatcttac gaatcaatac ttcaggtccc tctttcttca gacgggccac cagtggtttg
     7681 tcaatcatta aagaagaagc ggtaataatt ttactcctgt ccacgttttc aacaaaacgg
     7741 gctacataat cgttagccgg ttcggtcagt atttcttctg aagtacctac ctgcaccacc
     7801 tctccgtctt tcataatagc aatacggtcg cccagtttaa tcgcttcact caagtcatgg
     7861 gtaataaaga caattgtttt tttcatcttc gactgcaaag ccagcagttc atcctgcatt
     7921 tgcacacgaa tcagaggatc gagcgcagag aaagcctcat ccattagaag tacttcggga
     7981 ttattagcca gagcgcgggc cagtccgaca cgctgttgca ttccaccgga aagctcgccc
     8041 accatctgat tttcatatcc tttcaatccg acaagcttca tgctttccat cgctttcttc
     8101 tcacgttcct ctttcttcac tccctgaagt tcgaggccga acgcgatatt gctcaatacg
     8161 gaacggtgag gtaacagacc gaaattctgg aaaaccatcg ccagctcttt ccgacgaacc
     8221 tgcaataatt ctttttcgga aattttagat atatctactc cgtttacaag cacttgcccg
     8281 gtagtaggac gtatcagacg attgatacaa cgcagtaatg tcgattttcc acttcccgag
     8341 agtcccatta tcacgaaaaa ctctccttca ttaattgaaa gattggcatc tttcactcct
     8401 accgtacaac cggtatcttt cagaatttcc tctttactct tatctttttt caacatcttg
     8461 agggctttct gcttctcgtt accaaagata aggtacaaat cctttatttc tattttactc
     8521 atataatata ttggtttaga ttataatatt tgttttgttt tcaactgccg cattccttat
     8581 tctcacttac gataaacaag ttgaatgttc gcatggttca gtcatgtcac atgataacat
     8641 gacggtccga cgttttttaa atggttaaaa aaaaacagac agagtagttt aaaaggaata
     8701 gaatttgata agattatcct cttaatgaac agtagaaaac agtattttca taaataaata
     8761 acagtctgtt cttgcatatt gttggcacaa aggtaaggaa aatagattaa atatgcaaat
     8821 ttcattcagg tacggagtaa ttccaaagat gctttttcaa gtctacgcat ccattttgtt
     8881 tgaaagagat cccttcttcc aacaagagtt gtttctgctc tgtccaaccc ggaacaagcc
     8941 gtcccgacgc attgacaacc cgatgacaag gcgcagataa atcatccgga atctgtttca
     9001 aagcacgccc caccatacgg aaacattgag acattcccaa taatgcggca attcccccat
     9061 aggtagaaac tttacctacc ggaatttctc ggacaacctg atacacctct tgacaaaagg
     9121 atgcggaaag gctcgcctta tctactttat aatctttcat cactcaaaca ttactttatt
     9181 tcagttccaa aactagataa aaagaaaaga atttgcaaat aataaaagca tttcaaataa
     9241 aatatgcaac tttatttgct ttatttacaa ataatcccga cctttgtacc cattaaaagc
     9301 aaccctatta ttaacaaaac aagcactgct gttatgaaaa agaaaactat cctgttcgct
     9361 tcttgtttat tgggagcact ggctttcagc tcctgtgaga agaaccttta tgatgaaagt
     9421 aaacaacccg agaaagaaaa gaagatgact gacttggaag tacctgccga tttcgactgg
     9481 aaaggttctc aaaatgccaa agtgaaaatt gccagtcaat caactgctac tatttctgta
     9541 tttctagaag aaaattgcaa tgaagaggct ttgatgcttc gaatggatgt cgatgccaac
     9601 acatcaaaat tggaactccc aattgaaatt cctgcatata taaaaaatgt gtatgtaaaa
     9661 tatggtaatg gctctgaaat acaaactgtt cctgttgaaa gtaatggtac tatttccata
     9721 gtagtacctg ctaacgctac ggcattatcc agagttacca caagagctaa taaagaagtt
     9781 gaaacgaaca acatcttcaa ttatccggga tatggcaacg gaactattat gttcgaagat
     9841 atgtatccag ctttaggcga ttatgatttt aatgattttg ttgcatggta taatttccaa
     9901 attgacggtt tttattggag tcacaatcaa tgttatgcag aatacttaat gataggattc
     9961 caaatcagag ctataggagg tatatatgac tacaatcctt atatccgctt ggcagaagta
    10021 caatataatg aacttgattt agaagaaact caaatgtatc ttgagcgtaa caatcctgaa
    10081 gaggctgaaa atatcaaaat cctaaaaggc ccaaaagggg aattgattat ttcactaaag
    10141 aaaccggcca ttcctaacgg atacaagtat tataatacgg aggtaaatga aaaaacaaag
    10201 cctaaaaaaa tgatggccat ttacttggtg ttcaactcac ctgttaacgt taaaagccta
    10261 caagacagta aaatggactt ttatattgca aaaactaata aaggacaaga aatccactta
    10321 aaaggttata gcccggttta ttataacagc aacgaaagtt atgtaaatga agacaacttt
    10381 atatggggat taaaagtacc tgcatcttta catcatgcca gagaagaagt aaacttcttg
    10441 gaagcatatc cagactttga acaatgggta acatcgggag gtcaagagaa ccaaagatgg
    10501 tggaataagc caaaaacgaa taagttgatt atgaattaat aaatatacag taaatcatat
    10561 actgaattaa ataagaggta aggtatgtca atagatttcc ttacctctta tttttatcat
    10621 atgaattcca tagaagtata aacagataaa tgctcaccac caaattttgc agattctatc
    10681 ctatcctttc ctcttcaaca aatctgtcgg actctctcca aactgttctc tataacattt
    10741 agtaaaataa gaaggagaac taaaaccaac ttcataaccg atctctgcca ctgtcatatc
    10801 cgacgaggca agcagagaag cagctttctt caaacgagct atacgaagca gttcattcgg
    10861 agaataatta gtcagagatt taatcttgcg gtaaagttgc acacgactta atcccatatc
    10921 cttacccaaa tcttctacat tcaaatttga atctcccatc tttgcctcaa tcagagcttt
    10981 gaatttttcc acaaagtctt tatccatatc acagacatcc tctttcgcca acgtttgtcc
    11041 gtcaccaaaa aactgtttca ggcggcggtg tgaatctatc agattacgaa cgcgtgccaa
    11101 tagtaattgc gaactgaaag gcttggagat ataagaatct gcaccaccat catacccttg
    11161 aattcgttgt tcatccaaag aacaagctgt caataggata acaggaatat gacaggtttg
    11221 taattcgctt ttcaagcgac gacaacattc aattccatcc attccgggca tcattacatc
    11281 ggagataatc aagtccggga catatttcat agctttacga ataccttccg agccgtatgc
    11341 agcttctata acagtataat cagtgtgaag caatccatgc acatataagc gaatatcagc
    11401 gttatcatca ataatcagaa cgcaaggttt ggaagagtcg taactttttt ccaattcctc
    11461 ttcttcgtaa gttaaagcat cattcaagct cgaagaaccg gaataaccag aagttgcagg
    11521 agttacggga gccccagcaa cggcagaggt tgcagcatcg gtggaggtta cagaagtagc
    11581 agggacagag aatgccggag agttttcaga aacaacagtc tcgcaagtct gtacaggcaa
    11641 atcaacggta aagatagttc cttgcttttc atcactttcc actgtgatgg tacctttatg
    11701 caattccaca aaagccttta ccaatgccag tccaataccc gaaccggcat ggtgcatatc
    11761 tatcttatag aaacggtcga aaatattccg gatatgctcc gcagaaatca ttgagccggt
    11821 attggcaaca gtaaagcgaa tccaacaatg atcgtcttta gtcagggaag ataagcgtac
    11881 agttactttt ccattctccg gagtaaattt gaaagcgttg gaaaggaggt tgaaatagat
    11941 gcgttccaac ttttctacat ctgccaatgt gcggtaatcc gtatccggca tataatcgaa
    12001 tgagaaatga atatgtttct tccgggctgc tgccatgaaa gactcgttcc atccctcaaa
    12061 agaagaaaga atgtctaacg aaataggagt atattccatt tttccattct cgtatttacg
    12121 aaaatccaga atctgattga caagacgcaa gaggatattc acgtttcgct gaactaacaa
    12181 taacattcgg cgctgatctt cactcaaaga cgaatcagcc agtaaatgct ctaccgggtc
    12241 ggcaactaat gtcagtggag tacgaaaatc gtgagatata tttgtgaaga aaaccagctt
    12301 ggcatgagtc gcttcttcca gttgatgaga aagctggata agctgatccc gctgttcttc
    12361 gagtttgtca cgctgttctt caagaatatc ccgttgctct tcgagtttat cgcgctgttg
    12421 ctctacttgt ttcttctgtt cggacaactc tttattcagg cgattcttgg aacggaggga
    12481 tttatagact accaacaaca atcccgctac taataaaaga ataaccaagc cgccatacat
    12541 cacgacctgc tgcgtagcta cacgcgacag atacccaccg atacgtccgt tcaatgtttc
    12601 aatcttctga tccagttccg agatatgggt agtctgaagt tgcataacgt gcgcgttcgt
    12661 gcggtctaca acggcagtat tcatgaccgt ttcgcgagga taagacttct tctcaagaat
    12721 attcatggcc agttgcatca ctttgtcccc attagtcgga taaataaaag ttgcatcgag
    12781 cacattgtca agcaccaatt caagcccgtt tcctttgccg ggcagggcat caatgccaac
    12841 aaaaatcatt tccttttcac gtccggcttt cttcgcagct tgataggctc ccggagcgat
    12901 acggtcgtta tgtgcatata ccgcatcaat cttcggatga cggcgaagca tactatccat
    12961 ttccacttct gccggttcac gttcccaggc agcatccgct ttatcaatca gtttgatatc
    13021 cggataattg ctgatagcag ccataaatcc ctgatggcgt tccatggcag gggtggaacc
    13081 actcagtccg gtaagctcca ctacattccc tttccctttc agacttgatg cgatataatt
    13141 tcctaccgca cgacctattt cataattatc ggcaccgata taggcagtat atttatcaga
    13201 aagtatcttc cggtctacaa gaatgacagg tattcctttc tgataggcct cctccacaat
    13261 tggagtcatg ggagccgctt cattggcgga aattatcagt aaatcaactc ctttatctat
    13321 aaaataatga acatcttccg cctgcttacg gttatcatcc gccgccgagc ggatttcaac
    13381 cgacactcca tcataaaaca tcgcttcgcg aagaatctca tcattcatct tgtgcctcca
    13441 agagtcatcg ctacattggg ccaccccaat acggaaacga ggcgcatcct gccgacaggc
    13501 cgccaagccc aaaagacaaa acaagactgt tatccacttc gtatatttca tcgcttcaat
    13561 cattcccttt ctttcgtata tcttttgtat ttctttctgt aatccaaatt tctctccccg
    13621 cattatttgc attcaccacc gggaaataca tcagttccac tttcacaggg ttcagcgtat
    13681 attttccagt aaagcgtgga agcaaaggaa ccgtaaactg ataagtacct accggtaatt
    13741 tttcgctaaa gataacagtt ttctctttaa aatactcacg atatacttca gaacgggaga
    13801 aattaacagg ttttgaggca taactacaac ctgccggaac aggaacttcg agcatcacat
    13861 attgcgcacc ctcctgtttc acctgcaagg taactgtcaa tgtaacaggt acacccgcca
    13921 ccaaagagtc tttttccaaa gtcacctcca ccttgaaagc atcactctga cgagcattca
    13981 tcacacgctt cattgaatag acactataca ataaaggctc ttttcccgtt tttgaaataa
    14041 gcagactgtc gcctgctgtc agccgggcat gataaggaaa ttccataatt cgttgatgat
    14101 ccttaccgct cacagacacc gacgttcctg acatccctcc ggaacctgcc agcaaatcgg
    14161 tcagaacagt tgccacagcc gaagaagcct gatacgtatt ccatccgcgc tccttagtcc
    14221 gcaaaatata caattgcata ttttctttca acttacacag ggaagggtca tttttaataa
    14281 tccggtaggc tatcaatgta tttatcatct gatttccctc ccaataataa gtacgccgtc
    14341 cgtcgtcaca gtaaacacct tccagcatat cctttttcag ataaggacgt acgctatcac
    14401 ccacattcac cgaatccacc tgttgcttga tttcccagag aagcagcttc tctttcaagt
    14461 atgaaagagg acgataatac ttgtttctat ttgccaacga gtcttctttc tgttccaatt
    14521 gccggacgaa aggttccaat aatctgattg ccgaagaata atccgcctct actttccact
    14581 catgcagagc atgaagtatt tctatatctt ccagtttcat tcctcgataa ggacgcgtat
    14641 gagcatactc cactttcaaa ccattcagat tcaactccac aggataacct gcatcttgcg
    14701 ccatcttcaa agcccgcaga atatgcgcag acatccagaa agaagtattt tcagagttcc
    14761 cccaccacga ccataactga tgtttgttct gatgattcgt cagtcgatgg atgataggtc
    14821 gaattgcttt atctactttc accttttcac ccttactctg catatactgt tggtaagcca
    14881 acaaaccgat taacttggat gccagctgct cattgcacaa atatttgtat cctgtcaagt
    14941 aattcactga ttctttatag atgtccaact gattgtcagt gatactcacc atcacttctt
    15001 catcctcgcc ggattgcact ttgaccgtct ttgcatcgga cagaataccc aatgtgccct
    15061 ccgccaattc agttccctgt ggcagtatcg gaatcgtata ttcctcttca tcctgatagc
    15121 catcgtcgcg agtgaaaaga tagctgatgg tcacgctatc ggcatgaact gcctgcatcg
    15181 gcactgtttc atgaaatccc tccatgaaac tcacttcctg ccgtttcaac gtatccgttc
    15241 cgacgcagaa ctgtgtcttt ccggctatgt gctgcccatc cagataattg cggatagtcc
    15301 cgaccaccgt actctgatcc ccctccacca agaagcgggg agttttcaac tccgccatca
    15361 acggtttgta agagcggatg gaacgtcgga aagtacccgt ctgcaaacga cggttcatgc
    15421 cataaacgac agtt
//
