LOCUS       gnlProkkaOBCJLMGD_187  13705 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|OBCJLMGD_187.
ACCESSION   gnlProkkaOBCJLMGD_187
VERSION     gnlProkkaOBCJLMGD_187
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-30 19:20:55
            Original ID  :: gnl|Prokka|OBCJLMGD_187
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13705
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..843)
                     /locus_tag="ctg158_1"
                     /transl_table=11
                     /translation="MQTENFTLGKKELLILLGLILVLPFPINWALIELNPLTLMAGADD
                     VPTWIGFGGSYIGGIIGGVISIMILNKTLQQTGVLHHDLKLLQLDTIIYTQQQDWFTGF
                     KQELAENLKSIDLYVLNTVVSSISMKNYAYAKEVLTEINKGLEYQMVAASFSFTSTHLS
                     SEEKKYMSLVRRVQTEYSSFIKDILYYIPLAETISSRKKLNYDQLMDYTLSQYDYLQGQ
                     EGESTASGAIIPRVMEIDPSDDIRKELERIMEERLTGRTYLYHLKSDLAEATHQLIIYE
                     "
     protocluster    1..13705
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[847:3277]"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      848..3277
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
     cand_cluster    1..13705
                     /SMILES="NC([*])C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /kind="single"
                     /product="NRPS-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13705
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS-like"
                     /region_number="1"
                     /rules="cds((PP-binding or NAD_binding_4) and (AMP-binding
                     or A-OX))"
                     /tool="antismash"
     CDS             complement(848..3277)
                     /NRPS_PKS="Domain: AMP-binding (12-401). E-value: 3.3e-83.
                     Score: 271.4. Matches aSDomain:
                     nrpspksdomains_ctg158_2_AMP-binding.1"
                     /NRPS_PKS="Domain: PP-binding (509-568). E-value: 2.7e-10.
                     Score: 32.6. Matches aSDomain:
                     nrpspksdomains_ctg158_2_PP-binding.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: PP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     259.3; E-value: 9.5e-79)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg158_2"
                     /sec_met_domain="AMP-binding (E-value: 7.5e-88, bitscore:
                     284.2, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 4.8e-11, bitscore:
                     32.6, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTNIQENLSRSLSTWGDKPAVVAKDGTVSYQMLERYSANIAQSI
                     RQRLSVTDPSGLRNICIGVCMERNKTLVPAILAIFRLGATYLPIDPSLPDNRKRYMAEN
                     ADMVLLLTDSSNEVGGIPSVRQLYLNGEQLSEPVVGDYTEVLPNDCAYIIYTSGTTGNP
                     KGVRISYRNLDTFTRNLVDKKLYHLSDPANRYLAFASISFDASILELMMCIPVGGTLIL
                     AGEDERRDISLLDELIRREKVNIAFFPPSLLGMFADLDFPSFKTLLFGAEAIGEKLFNR
                     LKQQPYRLMNVYGPTENTVLSTIRIVGKDTSYDDIGYPLKGTVCYVLSENLQQTTLGAT
                     GELCLGGPQVSLGYIGSVQLNEKSFISYDGERLYRTGDLVQQQPDGSIRFIGRKDTQVK
                     IRGFRIELTEIAERLNRDPDVERAHVVVVERNGRQLLGAYLQPSVSGNFHPEEVKERLR
                     AELPYYMIPNLWQVVDHFQRTINDKIDVRALPAFTSLELKYVPPVHPGEVILCGILKEM
                     LGLPQVSVEADLIDDLGLTSLDMLRLVTEANKKGCPINVSAVYTARNLRRLLLVPRHEP
                     IYWYRQQNLKKPVIILVCGSAYFNHLYFNLADRLYPKYDFLVVDAIYDHFNKVATDIPE
                     LLEYYVRTVQPMIRERTVYALTGFCMGAELAVGLAEMLHRSMGIMPKVFALDGQAWQNP
                     ALCQNYPLLVFPGDTDEMVRKRNEIINIYFRTTPNLIYQGEVIVLLSGLFHQQAGLSPE
                     ESWTEENYRIFRTEYDNCERLWNKYYPNAPVLRLPADHWHFLEGESLEQLITVFLK"
     aSDomain        complement(1574..1750)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg158_2_PP-binding.1"
                     /evalue="2.70E-10"
                     /label="ctg158_2_PP-binding.1"
                     /locus_tag="ctg158_2"
                     /protein_end="568"
                     /protein_start="509"
                     /score="32.6"
                     /tool="antismash"
                     /translation="LCGILKEMLGLPQVSVEADLIDDLGLTSLDMLRLVTEANKKGCPI
                     NVSAVYTARNLRRL"
     aSModule        complement(1574..3241)
                     /complete
                     /domains="nrpspksdomains_ctg158_2_AMP-binding.1"
                     /domains="nrpspksdomains_ctg158_2_PP-binding.1"
                     /locus_tags="ctg158_2"
                     /monomer_pairings="X -> X"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(2048..2110)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg158_2_0004"
                     /evalue="1.50E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg158_2"
                     /protein_end="410"
                     /protein_start="389"
                     /score="36.2"
                     /tool="antismash"
                     /translation="FIGRKDTQVKIRGFRIELTEI"
     aSDomain        complement(2075..3241)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg158_2_AMP-binding.1"
                     /evalue="3.30E-83"
                     /label="ctg158_2_AMP-binding.1"
                     /locus_tag="ctg158_2"
                     /protein_end="401"
                     /protein_start="12"
                     /score="271.4"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="LSTWGDKPAVVAKDGTVSYQMLERYSANIAQSIRQRLSVTDPSGL
                     RNICIGVCMERNKTLVPAILAIFRLGATYLPIDPSLPDNRKRYMAENADMVLLLTDSSN
                     EVGGIPSVRQLYLNGEQLSEPVVGDYTEVLPNDCAYIIYTSGTTGNPKGVRISYRNLDT
                     FTRNLVDKKLYHLSDPANRYLAFASISFDASILELMMCIPVGGTLILAGEDERRDISLL
                     DELIRREKVNIAFFPPSLLGMFADLDFPSFKTLLFGAEAIGEKLFNRLKQQPYRLMNVY
                     GPTENTVLSTIRIVGKDTSYDDIGYPLKGTVCYVLSENLQQTTLGATGELCLGGPQVSL
                     GYIGSVQLNEKSFISYDGERLYRTGDLVQQQPDGSIRFIGRKDTQVKIR"
     CDS_motif       complement(2183..2269)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg158_2_0003"
                     /evalue="1.20E-08"
                     /label="NRPS-A_a6"
                     /locus_tag="ctg158_2"
                     /protein_end="365"
                     /protein_start="336"
                     /score="27.3"
                     /tool="antismash"
                     /translation="LGATGELCLGGPQVSLGYIGSVQLNEKSF"
     CDS_motif       complement(2771..2827)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg158_2_0002"
                     /evalue="1.50E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg158_2"
                     /protein_end="169"
                     /protein_start="150"
                     /score="26.8"
                     /tool="antismash"
                     /translation="AYIIYTSGTTGNPKGVRIS"
     CDS_motif       complement(3008..3049)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg158_2_0001"
                     /evalue="3.50E-03"
                     /label="NRPS-A_a2"
                     /locus_tag="ctg158_2"
                     /protein_end="90"
                     /protein_start="76"
                     /score="11.0"
                     /tool="antismash"
                     /translation="LAIFRLGATYLPID"
     CDS             complement(3290..5656)
                     /gene_functions="transport (smcogs)
                     SMCOG1082:TonB-dependent siderophore receptor family
                     (Score: 171.3; E-value: 7.8e-52)"
                     /gene_kind="transport"
                     /locus_tag="ctg158_3"
                     /transl_table=11
                     /translation="MKRCLLYILCCFGVVQLSAQPADNIRNSFVKAETFYKSGDIDEAC
                     RILEENLSSFQGTMHTEACRLAALCCLALDRFPEAEKYVSLLLKDEPYYYISLQDPERF
                     ADMVRKHRETKVTLVTASQQVETPEEAPVPVTLITEEMIRAIHARCLRDVLIAYVPGIS
                     GLSSNEEMNLAMRGVYSPEQENILIMQDGQRLNSYITNAVSPDYGISLAKVKQIEVLRG
                     PASSLYGSVALTAVINIVTKDGVDVRNGSISVSAGNRGQLAADLLLGKHDMNMDFMAWF
                     SLYRATGESVFVPAEKQYALYPRDGFIRLDNYSGFPAMDGGIKLQRGNLLFSFSMNYAK
                     KRQPYSMWLFSSPYSYERFRTFDGSGPGYSRWSAREQAVYSRTWQRITFSTTFYTDWNK
                     NVHYETSGDTLQDYPIFPNYDYQPIIYPTRGAFQYIRWMDFNVGFNGRVNYAYDWGKLG
                     KGNMLGGVEWNRYTLYDSEYLEGMNFKEIVRTWIEKRLYTGHEMNTDAFLQIKHNLHQN
                     WIVNAGIRYDYKRRSNKRTLQAFSPRLSLIYLRNGLNIKASYSRAFVDAPYYYRNNEMD
                     TYSGGENLQAEYLSSYQVTCAYHHSPSHIDVECNLFYNRASHFLFTQPETRVYENAGSL
                     DMGGVEVVARYKADRLSLDGNLCFQKVLNYTNFFVTDGSVNNVPGFSMNLVANYFLLKK
                     KVQSWSAHLKLNCSSHCYTQVSVLEDGLNGDATNYTVRLPGYAVFSFTTRYKYKRIEGS
                     LGIENLFNNRYECGGATVPIRQKGRWISASILYNF"
     CDS             complement(5653..6489)
                     /gene_functions="regulatory (smcogs) SMCOG1003:sensor
                     histidine kinase (Score: 136.3; E-value: 3e-41)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg158_4"
                     /transl_table=11
                     /translation="MEKNISQEKRIEELEARLKEQEKLGSLGLLSAGIAHEIQNPLNFV
                     INFSKLSGQLLADLADRVDEAKARIPEAELEDIKDILSGLRENVDKIKEHGDRAISIIR
                     GILLYSRGKEDEFMPTQIQKLTKEYVWLAYHAMRANYKNFNIAIREDYAKDIPSIRLIP
                     QDFSRAVLNVMNNACYAVWKKWQNAPEGYSPEIMVTLEKLDKRIVLSIRDNGEGMGPEV
                     KRKLFDSFFTTKPVGQGTGLGMAIVRDIIENKHHGKVLFDSVLHEYTCFRFIIPIA"
     CDS             complement(6512..9349)
                     /locus_tag="ctg158_5"
                     /transl_table=11
                     /translation="MKKIVFLIMCLCSVYANSQEGVPFFVNYPASVYQAHNRNFDVVCD
                     SCGNVYFANFEGILHYDYNRWETIYTPGFSRVTRLFRDSEGRIWVGGYNVFGRIERDGR
                     GCITLRTLLSDLDTDSLGELEDMAEIDKRIYLKATSGRYYTVQSDSILTPVQVLPAQLQ
                     EKWRNQSSVSMNRAFSLPGGETISINSAHGLIMDDSGKKERFSVTERNGLCSNAVSGIA
                     ADGRGNLWGATDNGVFHVFIPSLFSRYTSGEGLKGEVISAVSYKGMIYTGTLQGLYVLK
                     QNTFVPVQGISQACWQLCLSPQGELYAASGDGVYVIRDYNHSEKLTDMAAYSLAFIGHT
                     NLLMGTMDGIYQYSADEERIKKISDVEKVVRLEVKKDRSVWAKTLYGEIYLREEGESSF
                     VLQDRESEEVMTEYTDNDGCHWQTNLKGKEVQVHHSQIDTEKFNQCLYAIRNYVVRVIY
                     IEEDRAAWFGGDFGLIRMDLEKARTFTPVAPRIYLREVCLNRDSVYWGGDLPEESGGAD
                     WQINSTVPRLGNDVRSIRFSFATDAPCFTGSNEYRYRLVGYDPEWSSWDSGTVKEYANL
                     SSGTYTFCVRARDIYGTESEMKQFRFSLLPPFYLQWYCLILYTVAFGMLLFLLFKWRMR
                     SLLKEKERLEALVGQRTKQLVQQKNEIEEKSLKLEKALKELGQAQDELVRQEKMATVGK
                     LTQGLIDRILNPLNYINNFSHLTSGLLKDLYQNLESVKELLDEDTYLDSVDVINMMRDN
                     LEKIEEHGSNTTRVLKAMEEILRDRNRQLEKTELIGLCRKDMELLSSYYQKEITAMHIA
                     VRTSLPDNPLFIDGNAEQLGKTIMSLLNNGMYAIAKKYGKKAYPAEIGLALESKDGQAV
                     IRLYDNGVGIEQSILDKIFDPFFTTKTTGEAAGIGLYLSKEIILNHHGQIAVRSEKDEL
                     TEFTITLPLWEEKSV"
     CDS             complement(9346..10947)
                     /locus_tag="ctg158_6"
                     /transl_table=11
                     /translation="MIKLNENIIRWIIAVPCILLTVCLVLYRAYRHSASDRERLALSLE
                     EFRDKEKKSVLIQRVSQQMEEIAYQQKDISEKRRQEAVAQTQKANRMQQQAELARERAL
                     AAQLEAEKAYRMADEQKNLAMERQLQAEQSKRVADTLAFLALGRSLGTLSVTQYRSGNM
                     ELASLLAYTAWWFTKRYDGDVYHPAVFNALSLSCRQDQLWFGHKGAVTGIKLLSGGEEK
                     AKAGRNPLPGLVTVGKYGEMIRWKSENGQTYTSELLLNDPCYDFRDVLLRSDSQKYALS
                     YCGQLISTDSAGIVTRFLPKGEYRQLISIASNLVLAVSTTGIYSFDCINHEIQPCFQPE
                     HSITCVGQMEGYLYVFFKNGTVALLSSDGTFLRFIDSLPENSVVTAFCPLANERYAIGC
                     REGVILICDKNGNIRQKLIGHQAAVTAISRKGNKLFSSSYDCTLRLWDLRKGKTESAVI
                     VTSPGWIHTFCFHPDGTSVFMGDEQGRLYRVPISPDHMAAVVRQGLQRDFTREEWEYYI
                     GKQIPFESYYLKTYQP"
     CDS             complement(10944..11372)
                     /locus_tag="ctg158_7"
                     /transl_table=11
                     /translation="MTLLQFRPVDGRLDEILSMLMHSREVASHPSLSYAIRLVSEEIIV
                     NILNYAYPQQAEGYLTLCLWDEDGEITLEFIDGGIPFNPLDKADPDISLPLEQREIGGL
                     GIFLVREMMDDVAYTYVNKENRLTIKKKYLQPTDEPVS"
     CDS             complement(11387..11692)
                     /locus_tag="ctg158_8"
                     /transl_table=11
                     /translation="MEKYEIHSVGSVLDSNTSGDEQAKIVALIGQGHSVALDLSGCSYV
                     SSAGLRVMLYAFKLAKAKSKDVCLVGVSQEVKDVMHMTGFDKFFRFYQTLDELSQP"
     CDS             complement(11711..12880)
                     /gene_functions="other (smcogs) SMCOG1054:hypothetical
                     protein (Score: 220.1; E-value: 1.1e-66)"
                     /gene_kind="other"
                     /locus_tag="ctg158_9"
                     /transl_table=11
                     /translation="MAVKILSVDDELDLEVLLTQYFRRQIRKGEYEFAFAHNGLEALQK
                     LLETPDFDIILSDINMPEMDGLTLLAKVNELKNPAMKCIMVSAYGDMDNIRSAMNKGAF
                     DFATKPIDLDDLSRTIEKAIEQVRYIRESQQEHNQLESIKNDLAIAGEIQQTILPRSFP
                     PFPELTEVVDIYASMTPAKDVGGDFYDFFQIDDERIGLVIADVSGKGVPASLFMAVSRT
                     LLRATALRGVSSAECLTYANKLLCKESLDSMFVTVFYGIYHYKTGMMDYTNAGHNPPYL
                     LRGGRTVEFLPVASNFVVGVFDDIEFESNTLTFGIGDTLLLYTDGVTEAFNDKREQFSE
                     SNLQDILASMHESSSAKEVVTSVLQSVKTFSGDYPQSDDITLLSLQRIK"
     CDS             13228..13704
                     /locus_tag="ctg158_10"
                     /transl_table=11
                     /translation="MLIILKQDDSCQVAQTTCTTNSLEIRYKDYSVLKKTLDLNTKSIN
                     SDSCIELIIYGTHGNEKEICKLTKPDIKDLTYFFKGKVCRLVLDACHSACHIPHFKEML
                     TDDGIILCHVGICQVNSIETKTGKDTYERWINGNKEGLKVWSDGIVPAIYTQKNN"
ORIGIN
        1 ttcataaata attaattgat gcgtagcctc tgcaagatct gacttcaggt gatacaaata
       61 ggtacgcccg gttaatcttt cttccattat ccgttctagt tctttccgta tatcatcaga
      121 tggatcgatt tccataacac gcggtatgat ggctcccgaa gctgtagact ccccttcctg
      181 accttgcaaa taatcatatt gggacaaagt atagtccatc agctgatcat agtttagttt
      241 tttcctggaa gatatcgttt ctgccaaagg aatatagtaa agaatatcct tgataaaaga
      301 gctatattca gtctgtacgc ggcgtaccag actcatatac tttttttctt cggatgataa
      361 atgcgtagaa gtgaaagaaa aggatgcggc aaccatctga tattcgagcc ctttattgat
      421 ttctgtcaac acctctttgg catatgcata gtttttcatg gatatagacg aaacaaccgt
      481 attcaacaca tacaaatcaa tagatttgag gttctctgcc agttcttgtt tgaaaccggt
      541 aaaccaatct tgttgctgag tataaattat ggtatctaac tgcaggagtt tcaaatcgtg
      601 atgaagtaca cctgtctgct gaagtgtctt gttcagaatc ataatcgaga tgacccctcc
      661 gatgattcct ccaatataac tgccgccgaa accaatccag gtgggcacat cgtctgcacc
      721 cgccatcaga gtcaacggat tcagttcgat taatgcccaa ttgattggaa aaggcagtac
      781 aagaatcaag ccaagcaaaa taagaagctc tttcttacct aaagtgaagt tttcagtctg
      841 cataaatcta cttcaaaaac acagttatta attgttccaa tgattcccct tctaaaaagt
      901 gccaatgatc tgccggcaat cgcaaaacag gagcgttcgg ataatattta ttccataatc
      961 tttcgcaatt gtcatattct gtccggaata tacgatagtt ttcctccgtc cacgactctt
     1021 caggagacaa tcccgcctgt tgatggaaca atccggacag caaaacaata acctctccct
     1081 gataaatcag attaggagtg gttcgaaaat aaatatttat gatttcgttc cgtttacgta
     1141 ccatttcatc ggtatctccg ggaaatacca acaaaggata attttgacag agagccggat
     1201 tttgccaagc ctgtccatcc agagcaaaaa cttttggcat tatccccatg gagcgatgta
     1261 acatttcggc caggccgaca gccagttcag ctcccataca gaagccggta agcgcataga
     1321 cggtacgctc ccggatcatt ggctgaaccg tccggacata atattccaac agttccggaa
     1381 tatccgtggc cactttatta aaatgatcgt agatagcatc tacaactaga aagtcatatt
     1441 tgggataaag gcggtcggcc aaattaaagt acaaatgatt aaaataggca gatccacaaa
     1501 ccagaatgat tacgggtttc ttcaggtttt gctgcctgta ccaatagata ggttcatgcc
     1561 gcggaacgag caataatcgg cgcagattac gggcagtata aactgcagat acgttgatgg
     1621 gacatccttt tttattggcc tcggtaacaa gcctcaacat atccagcgaa gttaatccca
     1681 gatcatcaat caaatcggcc tcaacactga cttgaggcaa acctaacatt tccttcaaaa
     1741 ttccacataa gataacctcg cccggatgaa caggaggaac atacttcaac tccaatgaag
     1801 taaaagccgg gagcgcccgg acatcaatct tatcatttat agtacgctga aaatgatcta
     1861 ccacctgcca taaattgggt atcatgtagt aaggaagttc tgcacgcaaa cgctctttga
     1921 cctcttccgg atgaaagtta ccggagactg agggttgcaa ataagctccc aataattgac
     1981 gcccattccg ctcaacaact actacgtggg ctctctccac gtccggatct ctattcaatc
     2041 gttctgctat ttcagtcaat tcgatacgaa aaccacgtat cttgacctga gtatcttttc
     2101 gcccgataaa ccgtattgaa ccgtccggtt gctgctgtac caggtcacct gtcctgtaca
     2161 accgttctcc atcgtacgag atgaatgatt tttcattcag ctgaacactc ccaatatatc
     2221 ccagcgaaac ctgaggtcct cccaagcaaa gttctcctgt agccccaaga gttgtctgtt
     2281 ggaggttttc agacaaaaca taacagacag ttcccttgag cggatagcca atatcgtcat
     2341 acgacgtatc tttgcctaca atccgtatgg tactgagtac ggtattctct gtcggtccat
     2401 atacattcat caaccggtaa ggctgctgct tcagcctgtt aaataacttt tcaccaatag
     2461 cctccgcacc aaagagcaga gtcttaaagg atggaaagtc aaggtcggca aacatgccca
     2521 gcaacgaagg aggaaaaaaa gcaatattca ccttctcgcg cctgatcagt tcgtctagta
     2581 aagaaatatc tctgcgttcg tcctcaccgg ccaggatcaa tgttcctccg accggaatac
     2641 acatcatcag ttctaatatg gaagcatcaa aactgatact cgcaaacgct agatacctgt
     2701 ttgccggatc agacaaatga tacaatttct tatctaccag attcctcgta aatgtatcca
     2761 gattccgata actaatacgt acacctttgg gattacctgt tgttccggaa gtatatataa
     2821 tataggcgca atcattggga agaacttcag tatagtcacc aacaaccggt tcggatagtt
     2881 gctccccatt caggtaaagt tggcggacgg acggaattcc acctacttca ttcgatgaat
     2941 cggtcaacaa caaaaccata tccgcatttt cagccatata ccgtttacga ttatccggca
     3001 gcgagggatc tatcggtaaa taagttgccc ctaaccggaa aatagccaga atggcaggta
     3061 ctaaagtttt gtttcgttcc atacaaactc cgatacagat attccgaagt ccggacggat
     3121 cagttaccga taaacgttga cggatagatt gtgctatatt ggcagagtaa cgttccagca
     3181 tttgataaga gacggtaccg tcttttgcaa cgaccgccgg tttgtcaccc caggtagaga
     3241 gtgatcgaga aagattttct tgaatgtttg ttttcattat tagtttgatt tagaaattat
     3301 acaatatact ggcggaaatc caccttcctt tctggcggat aggaacagtc gctcctccgc
     3361 attcatatcg gttattgaaa agattctcaa tgcccagact gccttctatc cttttatact
     3421 tatatctggt agtgaaagaa aagacagcat aaccgggcaa acggactgtg taattcgtcg
     3481 catctccatt gagtccatct tccaatacac ttacctgagt gtagcagtgg ctactgcaat
     3541 tcaattttaa atgggcagac cagctctgta ctttcttttt aagtaaaaag tagtttgcta
     3601 caagattcat agaaaagccg ggtacgttat tcacagatcc atcggtaaca aaaaaattgg
     3661 tataattcaa tactttctga aaacacaggt ttccatccag gctcagtcgg tctgccttat
     3721 aacgggcaac aacctcgaca cctcccatat ccagagaacc ggcattttca taaacacgtg
     3781 tttccggctg tgtgaacagg aaatgggacg cccgattata aaataaatta cactctacat
     3841 ctatatgtga aggtgaatga tgataagcac aagtcacctg atatgaactt agatattcag
     3901 cttgcagatt ttcgccaccc gaataggtat ccatttcatt gtttctgtaa taatagggcg
     3961 catcgacaaa tgctctggaa taactggctt tgatatttaa tccgttcctg agataaatta
     4021 gtgacagacg gggagaaaaa gcctgtaatg tccgcttatt acttcgccgt ttatagtcat
     4081 acctgatgcc ggcattgaca atccaatttt gatgcaggtt gtgtttaatc tgaagaaagg
     4141 catccgtgtt catctcgtgt cccgtgtaaa gtcgtttttc gatccacgtc ctgacgatct
     4201 ctttaaaatt cataccttcc aaatactcgg aatcataaag cgtataccga ttccattcca
     4261 caccgccaag catattgcct ttccccagct tcccccaatc ataggcatag tttacacgcc
     4321 cattaaagcc tacgttaaaa tccatccagc ggatgtattg aaatgctccg cgagtcggat
     4381 aaataatagg ttgataatca tagttaggaa aaataggata gtcttgtaaa gtatctcccg
     4441 aggtttcata atgtacgttt ttattccaat cggtataaaa tgtggtactg aaagtgatcc
     4501 gctgccacgt gcggctataa acagcctgtt ctcttgccga ccacctggaa tatcccgggc
     4561 cggaaccgtc aaaagtacga aaccgctcat aagaatatgg agaagaaaag agccacatgc
     4621 tataaggttg ccttttcttc gcgtaattca tactgaaact aaaaagcaaa tttccacgtt
     4681 gcaatttaat tcctccatcc atggcaggaa atcccgaata attgtccaga cggatgaatc
     4741 cgtccctggg gtaaagagca tattgttttt cggccgggac aaaaaccgat tctcccgttg
     4801 cacggtacaa ggagaaccat gccataaagt ccatgttcat gtcgtgcttt cccaatagca
     4861 ggtcagcagc caactggccc cgattaccgg cgctgacaga tatggaacca ttacgaacat
     4921 ccaccccgtc tttagtaact atattaatca cggctgtcaa agccacactg ccataaagcg
     4981 aagaagccgg tccgcgcagc acctctattt gtttgacttt tgccagacta ataccataat
     5041 ccggcgaaac agcattagta atataactgt tcagacgttg tccatcctgc ataatcaata
     5101 tgttctcctg ttcgggagaa tataccccgc gcatagccag attcatctct tcattggaag
     5161 acaaaccgga tataccgggc acataagcta tcagtacatc ccgcaggcac cgggcatgga
     5221 tagcccgtat catctcctcc gtaattaaag taacaggcac cggagcttct tccggggtct
     5281 ctacctgttg tgaggctgtg accagagtta ctttagtctc cctgtgtttc cttaccatat
     5341 ccgcaaagcg ttccggatct tgaagcgaga tataataata aggttcgtct ttcaataaca
     5401 gcgaaacata cttttccgct tccgggaagc ggtctaaagc taaacagcat aatgcagcca
     5461 aacggcacgc ctcggtatgc atcgtacctt gaaaagacga cagattctcc tccaagatac
     5521 gacaagcttc atcgatatct ccgctcttat aaaatgtttc cgcctttaca aacgaattac
     5581 ggatgttatc cgccggctga gctgacagtt gcacaacccc aaagcagcaa agaatatata
     5641 gcagacagcg tttcatgcga taggaatgat aaaccggaaa caagtatatt catgcaggac
     5701 cgaatcaaac aatacttttc catggtgttt gttttctata atatcacgaa cgattgccat
     5761 accaaggcct gtcccctgcc ccaccggttt tgttgtgaaa aaagagtcaa atagttttcg
     5821 tttgacctcc ggacccatgc cctctccgtt atcacgaata gaaagtacaa ttcttttatc
     5881 caacttttct aaggtcacca ttatctcggg ggaatatcct tcgggagcat tctgccattt
     5941 tttccatact gcatagcagg cattattcat cacattcaag actgcccgac tgaaatcctg
     6001 cgggatcagc cggatcgagg ggatatcttt agcataatct tcacggatag caatattgaa
     6061 attcttataa ttggcccgca tggcatgata agccagccac acatattctt tagtcaattt
     6121 ttgtatttgt gtaggcatga attcgtcttc tttccccctg gagtaaagca aaataccacg
     6181 gataatgctg atagcccgat caccatgctc tttgattttg tccacattct ctctcagccc
     6241 ggaaagtata tctttgatat cttccagttc cgcttccgga atacgagctt ttgcttcatc
     6301 caccctatcg gccaggtcgg ccaacaattg accggacagt ttactgaaat tgatgacaaa
     6361 attcaaagga ttctgtatct cgtgtgcaat gcctgcactc aacaaaccca atgatcccag
     6421 cttttcctgc tctttgagcc gtgcttccaa ctcttcaatt cgtttctctt gtgaaatgtt
     6481 tttttccata atcaatctgt tctatgttta tttatactga cttttcctcc cacaatggca
     6541 gagtgatagt gaattctgtc aattcatctt tttcagaacg tactgctatc tgcccatggt
     6601 gatttaatat gatttcctta ctcagataca aaccgatacc tgctgcctct ccggttgttt
     6661 tggtagtaaa gaacggatcg aagattttat ccagaatact ctgctcgatc cccactccat
     6721 tgtcatatag gcgaatgact gcctgtccgt ccttactttc caatgccagg ccaatctctg
     6781 ccggataggc tttcttaccg tattttttgg ctatggcata cataccattg ttaagaagac
     6841 tcataatggt ttttcccagt tgttcggcat tcccgtcaat aaacaacgga ttatcgggca
     6901 aggaagtacg aaccgcaatg tgcatagccg taatctcctt ctgataataa ctgctcaata
     6961 gctccatgtc tttccggcat aaaccgatta attctgtttt ttccagttgc ctgttacggt
     7021 ctctcaggat ttcttccatg gccttcagta cacgagtggt gttacttcca tgttcctcaa
     7081 tcttttccag attatctctc atcatgttga tgacatctac cgaatccaag taggtatctt
     7141 catccaaaag ttcttttaca ctctccagat tctgatatag gtccttcagt aatcctgagg
     7201 tcaagtggga aaaattatta atgtaattca acggattcag aatacggtca atcaaccctt
     7261 gagtcagttt acctacagta gccatttttt cttgtcgaac caattcatct tgtgcctggc
     7321 ccagctcctt caatgctttt tccaatttta aggacttttc ctcaatttca tttttttgtt
     7381 gtaccaactg tttggtacgt tggccgacaa gggcctctaa cctctccttc tctttcagca
     7441 aactgcgcat tctccattta aacaataaga acaacagcat tccaaaagca acggtatata
     7501 ggatcagaca ataccattgc aaataaaaag gaggcaataa cgaaaagcgg aattgtttca
     7561 tttcactctc tgtgccgtaa atatcacggg cccggacaca aaacgtatac gtacccgacg
     7621 aaaggttggc atactctttc acagtcccgg aatcccacga actccattcc ggatcataac
     7681 cgaccaggcg atatctatac tcattggaac cggtgaaaca gggcgcatcg gtagcaaatg
     7741 aaaaacgaat ggaacgtaca tcattcccca aacgaggtac tgtactattt atctgccagt
     7801 ccgctccccc ggactcttcc ggcaaatctc ctccccaata gacagaatca cggttcagac
     7861 aaacttcacg aagatagatg cggggagcaa ccggagtaaa tgtccgggcc ttttcaaggt
     7921 ccatccgaat taaaccaaaa tcaccgccga accatgccgc cctgtcttct tcaatataaa
     7981 tcaccctcac gacataattc cgaatggcat acaggcattg gttgaatttc tccgtatcaa
     8041 tttgcgaatg atgtacctgt acctcttttc ctttcagatt tgtctgccaa tgacagccat
     8101 cgttgtccgt atactcggtc attacttctt cactctctct gtcttgaagt acaaaagagc
     8161 tttcgccctc ttcccgcaaa tagatttctc cgtacaacgt tttagcccat acagaacgat
     8221 ctttcttcac ttccagacga acgacttttt cgacatcgga aattttcttt atccgttcct
     8281 catctgccga atattgataa atcccatcca tagtgcccat cagaaggttc gtatgcccaa
     8341 tgaatgccaa tgaataagct gccatatctg tgagtttttc cgaatgatta taatcccgga
     8401 tcacatacac accatcgccg gacgctgcat ataattctcc ttgtggagaa agacacagtt
     8461 gccaacatgc ttgcgaaatt ccctgaacag gaacaaaagt gttttgcttc aatacgtata
     8521 atccctgtaa ggtcccggta tatatcattc ctttgtaaga gacagccgat attacctctc
     8581 ccttcagacc ttcaccagag gtataacggc tgaacaaaga gggaataaaa acatgaaaca
     8641 caccgttatc cgtagctccc cagagattgc cacgcccatc ggccgcaata cccgaaacag
     8701 cgttactgca taagccattt ctctcagtta cggaaaaccg ttcttttttc ccactgtcat
     8761 ccattattaa tccatgggca gagtttatcg agattgtttc tcctccgggt agagaaaacg
     8821 cccgattcat tgagactgag gattgatttc tccacttttc ctgcaattgg gccggaagta
     8881 cctgaaccgg tgtcaaaatg gaatctgact gaaccgtata atatcttcct gatgtagctt
     8941 tcagataaat gcgtttatct atttctgcca tatcttccaa ttcgcccaaa gagtctgtgt
     9001 ccagatcgga aagaagggtt ctcaacgtaa tacatccgcg tccatcacgc tctatccgtc
     9061 cgaacacgtt atatcctccc acccatatcc taccttccga atcacgaaac aaacgggtga
     9121 cacgggaaaa gcccggtgta taaatagttt cccaacggtt atagtcataa tgaaggatac
     9181 cttcgaaatt agcaaaatag acatttccac aactgtcgca aacgacatcg aaattacgat
     9241 tatgcgcctg ataaaccgaa gccggatagt ttacaaaaaa cgggacaccc tcttgtgaat
     9301 ttgcatatac cgagcaaaga cacattatca aaaagactat ctttttcatg gctgatacgt
     9361 ttttaggtaa taggattcaa atggaatttg cttaccgata taatactccc attcttctcg
     9421 agtaaaatca cgctgtaacc cctgacggac aacagcagcc atgtgatcgg gtgaaatagg
     9481 cacccgatac aaccgcccct gttcgtctcc cataaagaca gatgtaccgt ccggatgaaa
     9541 gcaaaaagta tgaatccaac cggggcttgt cacaataaca gccgactcgg tctttccttt
     9601 acgaagatcc cacagacgca gcgtacaatc gtaactactc gaaaacagtt tgttcccttt
     9661 ccgggaaata gcagtaaccg cagcctgatg ccctatcaac ttctgccgga tatttccatt
     9721 cttatcacaa atcaggataa ctccttcacg acagccaatg gcatatcttt cattggcaag
     9781 aggacagaat gcagtaacca cactattctc gggcaagctg tctataaatc tgagaaatgt
     9841 accatccgac gaaagtaaag ctactgtccc attcttaaaa aaaacataga gatagccttc
     9901 catttgaccg acacaagtta tcgaatgttc cggttgaaaa caaggttgta tctcatggtt
     9961 gatacagtca aaagaataaa taccggttgt ggaaaccgcc aataccaagt tagaggcaat
    10021 cgaaatcaat tgccgatatt ctcctttagg caaaaagcgg gtaacgatac cggcggaatc
    10081 cgtggagata agctgcccgc agtatgacaa ggcatacttc tgtgaatcgg accgcaacag
    10141 cacatcccga aaatcataac agggatcatt caacagtaat tcggaggtat aggtctgccc
    10201 attttccgat ttccaacgta tcatctcacc gtacttgccg acagtgacca atcccggcag
    10261 aggattccga ccggcttttg ctttttcctc gcctccggat aacagtttga tcccggtaac
    10321 agctccttta tgcccgaacc aaagctgatc ttgcctgcaa gacaaagaca atgcattgaa
    10381 aacagccgga tgatatacat cgccatcata tcgcttggta aaccaccagg cggtatatgc
    10441 caacagagaa gctaattcca tgttgcccga ccgatattga gtaacagaga gtgtccccaa
    10501 tgaacgtccc aaagccagaa aagccaatgt atcggcaacc ctcttcgact gttcggcctg
    10561 tagttgccgt tccatcgcca gattcttttg ttcatctgcc atccgatacg ctttctcagc
    10621 ctccaattgt gcagcaagcg ctctttcccg tgccaactct gcctgctgtt gcattcggtt
    10681 ggccttttga gtttgcgcaa cggcttcctg tcttctcttt tcggaaatat ccttttgttg
    10741 ataagcaatc tcctccattt gttgactgac ccgttgtata agaaccgatt tcttttcttt
    10801 atcccggaat tcctccagag acagagcaag gcgctccctg tccgatgccg aatgacgata
    10861 tgcccggtat aggaccagac atactgtcaa aagtatacaa ggaacggcaa tgatccaacg
    10921 gatgatattt tcgtttaact tgatcatgat acaggttcat cagtgggttg cagatatttc
    10981 tttttaatgg tcaaccgatt ctccttattc acgtacgtat acgctacgtc atccatcatt
    11041 tcacgtacca ggaaaatgcc caatcctcct atttcacgct gttctaacgg taatgaaata
    11101 tcaggatcgg ctttatccaa aggattgaat ggaataccac catctataaa ctccaaagta
    11161 atctctccgt cttcatccca taagcacaga gtcagataac cttctgcctg ctgcggataa
    11221 gcgtaattga gaatattgac aatgatctcc tcactgacca aacggatggc ataagacagg
    11281 gaaggatgtg aagcaacttc acgactatgc atcagcatac taagaatttc atctaacctc
    11341 ccatcgacag ggcgaaactg aagtaacgtc attgctcagg taatttttag ggttgtgata
    11401 attcatcgag agtctgataa aaacgaaaga atttatcgaa tccggtcatg tgcatcacgt
    11461 ctttaacctc ttgtgacaca ccgacaaggc aaacatcctt acttttagct ttcgccagct
    11521 taaaagcata aagcatgact ctcaatccgg cactggatac ataagaacag ccgctgagat
    11581 ctaatgcaac agaatgtcct tgcccgataa gagctacaat ttttgcttgt tcgtcaccgc
    11641 ttgtatttga atccaagacg gaacctacag aatgaatttc atacttttcc atcgttcttt
    11701 tattttaata ttatttgatt cgttgaagag aaagcagggt tatgtcatcg gactgaggat
    11761 agtctccgga gaaagtctta acagactgca atacactcgt aacaacctct tttgcggaac
    11821 tactttcgtg catagacgcc aatatatcct gtaagttact ttccgagaat tgttcccgct
    11881 tgtcgttaaa agcctctgtg acaccatccg tatacagaag taaagtgtca ccgatgccga
    11941 acgtcaatgt attactctca aattcaatat catcgaatac gcctaccaca aaattagaag
    12001 cgacaggcaa gaattcaaca gtccgtccgc cacgaaggag ataaggggga ttatgcccgg
    12061 cattggtata gtccatcatg ccggttttat aatgataaat cccataaaag accgtaacaa
    12121 acatagagtc caggctctct ttacacagta acttattggc ataagtaagg cattctgctg
    12181 acgaaacacc ccgaagagca gttgcacgga gcagggtccg actaaccgcc atgaacaagg
    12241 atgccggcac ccctttcccg gatacgtcag caatcaccag cccgatacgt tcatcgtcaa
    12301 tctggaagaa atcataaaaa tcgccaccta catcttttgc cggagtcatg gaagcataaa
    12361 tatcaaccac ttccgtcagt tccggaaaag gaggaaagga acggggaaga atcgtttgct
    12421 ggatttctcc cgcaatggcc aggtcatttt tgatagattc cagttggttg tgctcctgct
    12481 gtgactcacg gatatagcga acctgttcga tcgccttttc aatagtccgc gacagatcat
    12541 ccaaatcgat cggtttggtt gcaaaatcaa acgctccctt gttcatagca gaacgtatgt
    12601 tatccatgtc tccataagca gagaccatta tacacttcat tgccggattt ttcagttcat
    12661 tgaccttagc caatagggtc aacccatcca tctccggcat attaatatca ctcaggatga
    12721 tatcgaaatc gggagtttcc agaagtttct gtaaagcttc caacccgtta tgggcaaaag
    12781 cgaactcgta ttcacctttt cgtatttgtc gcctgaagta ctgggtaagt aatacttcta
    12841 aatcaagttc atcatctaca ctcaatattt ttactgccat atctattgtt atttatgaat
    12901 ttcaaccgtt tgttctgacg tttatgatgg caaaaataga gagtgaccgc cccggttaca
    12961 attttatatt ttaaacagga agaatgtttt tccgaatgga cgatattgtc ttataagcat
    13021 acaggtatat tgctttcgtg gcttagaaga cagcacctga aagattgatt tacactcctg
    13081 aaagaaacta ttccgtattc agaatttata tttttaagat ggaacttttc ttctcacttt
    13141 tgtcaccgta agcttacaaa gaataaatag aaacggcgga ttccgaaaag ccgaagaaag
    13201 agtaggaact ttttacgaat cactattatg cttattattt taaaacaaga tgatagttgt
    13261 caagttgcac aaacgacatg tacaacaaac tctttagaaa tccgatacaa agattatagt
    13321 gtactgaaaa aaactctgga tttgaacaca aaatctatta atagcgatag ctgtatagag
    13381 ttaattattt acggaacaca cggaaatgaa aaggaaattt gcaaactaac caaaccagac
    13441 ataaaagatc tgacctattt cttcaaagga aaagtttgta gattagttct tgatgcttgc
    13501 catagcgcct gccatattcc acatttcaaa gagatgttaa cagatgatgg aatcatatta
    13561 tgtcatgtag gtatctgcca agtaaacagc atcgaaacta aaacaggtaa agacacctat
    13621 gaacggtgga taaatggcaa taaggaagga ttaaaagtat ggtcggatgg aatcgttcca
    13681 gctatctata ctcaaaagaa taaca
//
