LOCUS gnlProkkaOBCJLMGD_406 16052 bp DNA linear UNK 01-JAN-1980 DEFINITION gnl|Prokka|OBCJLMGD_406. ACCESSION gnlProkkaOBCJLMGD_406 VERSION gnlProkkaOBCJLMGD_406 KEYWORDS . SOURCE ORGANISM . COMMENT ##antiSMASH-Data-START## Version :: 7.1.0 Run date :: 2024-11-30 19:20:55 Original ID :: gnl|Prokka|OBCJLMGD_406 NOTE: This is a single region extracted from a larger record! Orig. start :: 0 Orig. end :: 16052 ##antiSMASH-Data-END## FEATURES Location/Qualifiers protocluster 1..16052 /aStool="rule-based-clusters" /category="RiPP" /contig_edge="True" /core_location="[5698:6052]" /cutoff="10000" /detection_rule="minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])" /neighbourhood="10000" /product="RRE-containing" /protocluster_number="1" /tool="antismash" proto_core 5699..6052 /aStool="rule-based-clusters" /tool="antismash" /cutoff="10000" /detection_rule="minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])" /neighbourhood="10000" /product="RRE-containing" /protocluster_number="1" cand_cluster 1..16052 /candidate_cluster_number="1" /contig_edge="True" /detection_rules="minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])" /kind="single" /product="RRE-containing" /protoclusters="1" /tool="antismash" region 1..16052 /candidate_cluster_numbers="1" /contig_edge="True" /product="RRE-containing" /region_number="1" /rules="minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])" /tool="antismash" CDS complement(268..453) /locus_tag="ctg292_1" /transl_table=11 /translation="MLTSYSSLIKILLFDNQLLIFWMHSVVKFFSYVQDVRSCLFIKLP LRLSIACLSTYFHILL" CDS complement(601..1236) /NRPS_PKS="Domain: oMT (51-151). E-value: 4.4e-15. Score: 46.5. Matches aSDomain: nrpspksdomains_ctg292_2_oMT.1" /gene_functions="biosynthetic-additional (smcogs) SMCOG1089:methyltransferase (Score: 99.4; E-value: 3.7e-30)" /gene_kind="biosynthetic-additional" /locus_tag="ctg292_2" /transl_table=11 /translation="MNKRGFVSKILQNFRKPEGFFGRMILWGMNTGHASLAQWGMSCLQ WQPEWSVLDIGCGGGANLLQILQRCPQGKAYGIDISSESVTFARKKNKKYLGTRCFIEQ GGVHRLPYPDYAFDAVTAFETVYFWGNLQHAFTEVARVLKPGGSFLICCEISDPANKAW TGLVEGMEIHSCDELKAILSKSGFTDTAIFRTKKEELCLVSHRQTVRL" aSDomain complement(784..1083) /aSDomain="MT" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg292_2_oMT.1" /domain_subtypes="oMT" /evalue="4.40E-15" /label="ctg292_2_oMT.1" /locus_tag="ctg292_2" /protein_end="151" /protein_start="51" /score="46.5" /tool="antismash" /translation="VLDIGCGGGANLLQILQRCPQGKAYGIDISSESVTFARKKNKKYL GTRCFIEQGGVHRLPYPDYAFDAVTAFETVYFWGNLQHAFTEVARVLKPGGSFLI" CDS 1542..2882 /locus_tag="ctg292_3" /transl_table=11 /translation="MNNVQQVKTYSQRKISDFLFILWAGGAALLSYSLVYALRKPYTAA GFDGLEAFGMDYKVVVTIAQILGYVLSKFIGIKLISELKRENRMKFILISIILAEASLI LFGLLPAPYNTGAMFLNGLSLGCMWGIIFSFIEGRRMTDILASLLGVSMVISSGTAKSA GLYVMDTLNISEFWMPALIGGVALPLLALLGYALNRLPQPTAEDIAIKSKRETLNGKQR WELFKNFMPFLTLLFIANVVLTILRDIKEDFLVKIIDVSQYSSWMFAQVDSVVTLIILI IFGLMVFVRSNLKALSILLGLIIASMVVMAVVSFGYEQLQLNAIVWLFIQSLCLYLAFL TFQTIFFDRFIACFKIRGNVGFFIAMNDFLGYTGTVIVLAVKEFFSPDINWTAFYNLMA GYVGIICFVAFVCSFIYLHQRYRRENYGKTGVFRKKEEEKEVPDFVY" CDS 3127..4437 /locus_tag="ctg292_4" /transl_table=11 /translation="MLAEKEYKVEAYLFNPKGELSADCQTNKELVEMMDNVKFSEVSTQ FVPPALTMDHLVVDGLFGSGLNKPLSGGFAAVVKYINASPATVVAIDIPSGLMGEENTF NVKANIIRAQLTLSLQLPKLAFLFAENSEFVGEWKLLDINLSREAIEETESNYALLEAE EIHALIKPRNTFSHKGNFGHALLIAGSYGMAGASILAARACMRSGVGLLTVHAPIRNND ILQISVPEAIIESDASDTYFACPTDTDDYQAVGIGPGIGRSEETEAALLEQLSGCQTPL VLDADALNILANHRHALTTLPKGSILTPHPKELERMVGKCQNSYERLMKACELARTAKV HIILKGAYSAIITPSGKCYFNSTGNPGMATAGSGDVLTGVVLALLAQGYPAEEAAKIGT YVHGLAGDFARKKQGVISMTAGDIISNLPLAWRLVSE" CDS 4510..5565 /locus_tag="ctg292_5" /transl_table=11 /translation="MKKLIILTGLLLSTSAYAQTEVTAGVTRGKDYGVTYALPKTAINI EVKVNKVTYTPGEFSKYADRYLRLTDVSGEPQEYWELVSVKAKSVGIPDSEHTYFVKLK DKTVAPLIELTEDGIVKSINVPLSPKKSAPMQPATTQKKKINPRDFLTEEILMAGSTAK MAELVAKEIYNIRESKNALVRGQADNMPKDGEQLKIMLANLEEQEAAMTEMFSGTLNKD EKIFNIRLTPDKEMDNEVAFRFSKKLGIVANNDLAGEPVYITLKNLKTVNVPEDDGKKK VDGIAYNVPGKAQVTLTEGKKQWFNEELPVTQFGTIEYLAPALFNKKSTVQVTFNPDTG GLIKVDREEGE" CDS complement(5699..6052) /gene_functions="biosynthetic (rule-based-clusters) RRE-containing: PqqD_RRE" /gene_functions="biosynthetic-additional (rule-based-clusters) PF05402" /gene_kind="biosynthetic" /locus_tag="ctg292_6" /sec_met_domain="PF05402 (E-value: 3.1e-17, bitscore: 53.2, seeds: 461, tool: rule-based-clusters)" /sec_met_domain="PqqD_RRE (E-value: 4.4e-10, bitscore: 29.8, seeds: 9, tool: rule-based-clusters)" /transl_table=11 /translation="MADVKEKINLLDVIPFRSENITAEKGSDGTVTIAFPRFKYEWMRR FLLPKGMSADIHVRLEDHGTAVWELIDGKRTVRRIIEELAEHFNYEENYESRITAYITQ LQKDGFVKLVIEN" CDS complement(6059..7321) /gene_functions="transport (smcogs) SMCOG1106:major facilitator transporter (Score: 82.1; E-value: 5.1e-25)" /gene_kind="transport" /locus_tag="ctg292_7" /transl_table=11 /translation="MLEKELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFT GMGACILMVLGCGLKYYAISTTFPEGALIMGFKTQVFLAALGYAIFGVGVEIAGITVSK IIVKWFKGKEMALAMGLEMATARIGTTLAMVLTVPIADYFGYTDESGSFHTNIPMPILL CLIMLCIGTIAFFIYTFYDKKLDASLDAQGEEPEEPFRMKDVMLIVTNKGFWLIALLCV LFYSAVFPFIKYATDLMVQKYNVDPKLAGNIPGLLPIGTIFLTPLFGTLYDRIGKGATL MIIGAVMLIGVHTLFALPILNVWWFATVIMIVLGIAFSLVPSAMWPSVPKIIPEKQLGT AYALIFWVQNWGLMGVPLLIGWVLNTYCKGPVVDGAQTYDYTLPMAIFACFGVLALIVA LMLKAEDKKKGYGLQEANIKK" CDS complement(7618..7878) /locus_tag="ctg292_8" /transl_table=11 /translation="MGVRKTTDFLEKATWGLAAFMVVMSIATAYVVPTSSSKTQDVIME QAQQEEQTNPYNLPVGTTAPKTDAAAPVEAPATETPATPAN" CDS complement(8003..8758) /locus_tag="ctg292_9" /transl_table=11 /translation="MISANLQQWIQHPETLNKDTLYELRTLVTRYPYFQSLRLLYLKNL YLLHDISFGAELRKAILHVADRRKLFYLIEGERYILKPRKKNALPETEVLEEEPSLDRT LSLIDAFLATVPEEVSAQTSLDYATDYTTYLLQEDDTPELEETPKLRGHELIDGFIERS EEETSIRLQPADENKAISEEEESETHHEEDEDDSCFTETLAKIYVKQHRYSKALEIIKK LSLKYPKKNAYFADQIRFLEKLIINAKSK" CDS complement(8764..9285) /locus_tag="ctg292_10" /transl_table=11 /translation="MDWNKKIMRISLLVFTLVVGISCTVSYKFNGGNINYDKVKTISIA DFPIKSDYVYAPLGTKFNEDLKDIFLRQTRLKLVNNNADLEIDGEITGYNQYNQAVSAD GYSSETKLTITVNVRFVNNTNHEQDFEQQFSAFRVYDSRELLTAVQDGLIAEMTKEITD QIFNATVANW" CDS complement(9272..10498) /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54 dependent trancsriptional regulator (Score: 389.6; E-value: 3.4e-118)" /gene_kind="regulatory" /locus_tag="ctg292_11" /transl_table=11 /translation="MTKAEIQQVKLRFGIIGNTEALTRAIDVAIQVAPTDLSVLITGES GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG EADGGTIFLDEVGELPLPTQARLLRVLESGEFIKVGSSKVQKTDVRIVAATNVNLTQAI AEGRFREDLYYRLNTVPIQIPPLRERGEDVLLLFRKFASDFAEKYRMPAIQLTEDAKRV LLSYSWPGNVRQLKNITEQISIIETNREINAPILQSYLPAQSTQRLPALFGVKTGKSFE SEREILYQVLFDMRQDVTELKKLVHEIMSERGAVTSNVGTFYTPAPVVAPTPSVPAIIH PVKPNCPDDDDIQDTEEYVEESLSLDEVEKEMIRKALEKHHGKRKSAAKDLNISERTLY RKIKEYGLE" CDS complement(10523..11620) /locus_tag="ctg292_12" /transl_table=11 /translation="MEDNKIKIGITQGDINGVGYEVILKTFADPVMLELCTPVIYGSPK VAAYHRKSLDLPTNFSIVNTAAEAAHNRLSVVNCTDDEVKVEFSKPDPEAGKAALGALE KAIEEFREGLIDVIVTAPINKHTIQSEGFAFPGHTEYIEQRLGNGSKSLMILMKEDFRV ALVTGHIPVREITSSITKELIQEKLAIFNRSLKQDFGIGAPRIAVLALNPHAGDDGLLG TEEQEIISPAIQEMAAKGILCYGPYPADGFMGSGNFTHFDGVLAMYHDQGLAPFKALAM DEGVNYTAGLPVIRTSPAHGTAYDIAGKGVACEDSFRQAIYVAIDVFRNRQREKEAHAN PLRKQYYEKRDDSDKLKLDTVDDDI" CDS complement(11625..11972) /locus_tag="ctg292_13" /transl_table=11 /translation="MKANIPGAKEGMYMATDSSTVEVRPIDIHGDYTMEARGLWRIKGD FMGGPFVSHTRLDKASHRIITTEVFIYSPDKMKRDLMRRLEASLYTLQLPTEKAQEQIP MGIEQEEKTNK" CDS complement(12746..13423) /locus_tag="ctg292_14" /transl_table=11 /translation="MTGKQGFTASLTANQILNQIAALPERDKLTNVVMMGMGEPLDNLD EVLKALHILTASYGYGWSPKRITLSSVGLRKGLQRFIEESECHLAISLHSPFPSQRSEL MPAERAFSIKEMVDLLKNYDFSKQRRLSFEYIVFKGVNDSLIYAKELLKLLRGLDCRVN LIRFHAIPGVDLEGAGMEAMTSFRDYLTSHGLFTTIRASRGEDIFAACGMLSTAKQEES NKN" ORIGIN 1 ataatcgggt acagaaaaag tattcgcacc ggatttgaat actatccgat acgttgaatt 61 attttatttt aaacatatat cggacataaa gaaaagtata tttgtccgcc tatatattta 121 cgggtgcaaa ggtaaaacct tcttttgagt ctccaaaact tttcacaggt tattttcatc 181 ataggaagtt atatgactga atatcaaaga tataatttat ctctttgcaa ataaggaaag 241 cagcaatata cataatacta atgtggctta taaaagaatg tggaaataag tggagaggca 301 ggctatggag agtcttaacg gtaacttgat aaacagacaa ctacgcacat cttgaacgta 361 agaaaagaat tttacgacag aatgcatcca gaatataagc aattgattat caaacaataa 421 tatcttaata agagaactgt aggaagttaa cattaacagt acgttaatat taacttcgta 481 attgcaagat attaattctt tagagatacg aagttaataa gctattgata aggagggaaa 541 gcacttttac gggcattaac attgttaacg tattcgttgg taagagcgtc ccggcattgg 601 ttacaaccgc acagtttgcc gatggcttac caggcacagt tcttctttct tcgtccggaa 661 tatggccgtg tcggtaaaac cacttttgga aagaatcgcc ttcagttcat cacaggaatg 721 aatctccatc ccttcaacaa gtcccgtcca agccttattg gcaggatcgc ttatctcaca 781 acagataaga aaagatccac cgggctttaa cacacgcgcc acttccgtaa aagcatgctg 841 caggttaccc cagaagtaga cagtctcgaa agcagtgacc gcatcgaacg cataatcagg 901 atagggaagt cggtggactc ctccctgctc gataaagcag cgtgtaccga gatacttttt 961 atttttttta cgcgcaaagg tgacactctc cgatgaaata tctatgccat acgctttccc 1021 ttgcgggcaa cgttgcaata tctgtagcaa attggcacca ccaccgcaac cgatgtcgag 1081 tacactccat tccggttgcc attgcaagca tgacattccc cattgcgcca atgatgcatg 1141 tcctgtattc atcccccaaa gtatcattct tccgaaaaaa ccttcaggct tccggaaatt 1201 ctgtaagatc ttgcttacaa agcctctctt attcatttgt ctgctgattt aatatttcag 1261 gcaaaagtac agtttctgcc caaacaagca atacccagaa atagggaatt tatttcctaa 1321 aagatatttg caggtatgca tctgcttccc gttaaaatta tgacgaacag atgcccggag 1381 gtgcgatgct cttttcgttt ccgtttcata aatattacat aaacattaca acataacaga 1441 ttcattatca atatctatta ataataaaca ttcatatatt cagtaacagg tctgtaacac 1501 taccctccta tttttgcacc ggaaaacaac aagcagatgt tatgaacaat gtacagcaag 1561 taaaaactta ttcgcagaga aaaatttctg atttcctttt cattctttgg gcaggcggag 1621 cagcgctgct ctcctattca ttggtatatg cactgagaaa gccttacaca gcagccggat 1681 ttgacggact tgaagcgttt ggaatggact acaaagtggt agttaccatc gcacaaatat 1741 taggatatgt actttctaaa ttcatcggaa ttaaattaat ctccgaattg aaacgggaaa 1801 accggatgaa gtttattctg atctccataa ttctggctga agcttcgtta atattgttcg 1861 gactgttgcc cgcaccttat aatacaggag ccatgtttct gaacggactt tcactgggat 1921 gtatgtgggg aatcattttt agctttatcg agggaagacg aatgacggac attcttgcca 1981 gcttactcgg agtcagtatg gtcatcagct cgggtaccgc caagtcggcc ggtttgtatg 2041 tcatggacac tttgaacatc agcgaattct ggatgcctgc cctgataggc ggagttgccc 2101 ttcctctact tgccttgttg ggatatgcac tcaaccggct tccacagcca acagccgaag 2161 acattgccat aaaatcgaaa cgggaaacac tgaacggcaa gcaacgatgg gagctattta 2221 agaatttcat gcctttcctc actctgctct ttatagctaa tgtggtactg actatcttga 2281 gagatataaa ggaggacttc ctggtaaaaa ttatcgatgt ctctcaatac tcttcgtgga 2341 tgtttgcaca ggtagacagc gtagtaaccc tcattattct gataattttc ggattaatgg 2401 tgttcgtcag aagcaacttg aaagcactgt cgatattact gggattgatc attgccagca 2461 tggtagtgat ggcagtcgtt tcgtttggtt acgaacaatt gcagctgaac gccatcgtct 2521 ggctattcat ccagagcctg tgtctctatc tggcttttct cactttccag actatcttct 2581 tcgaccgttt tatcgcttgc ttcaaaattc gaggtaacgt gggtttcttc attgctatga 2641 atgattttct gggctatacg ggaacagtca tagtattggc tgtcaaagaa ttcttttcac 2701 cggacattaa ctggacagct ttctacaatc tgatggcagg atatgtggga ataatctgtt 2761 tcgttgcttt tgtatgctct ttcatctacc tgcaccaacg ctaccgcagg gagaattacg 2821 gaaagacagg ggtattcaga aaaaaagaag aagaaaaaga agttcccgat ttcgtatatt 2881 aattgctatc tttgtgggtc aaaaaactta aaatgaaagt tcaccatgaa gatttttcca 2941 agtagcagca tcaagaaact ggatgcttac accatagaac atgaaccgat tgcatcgatc 3001 gacctgatgg agcgggccgc acaggcactg accaaagcca tcaccgaacg ctgggacatc 3061 acaactcccg tcacggtatt tgccggaccg ggcaacaatg gcggagatgc ccttgccgta 3121 gcccgaatgt tggcggaaaa ggaatacaag gtcgaagcct atctgtttaa cccgaaaggg 3181 gaactgtctg ccgactgcca gaccaacaag gagctggtag agatgatgga taatgtgaag 3241 ttcagcgaag taagcacaca gtttgtacct cctgccctga caatggatca tctggtagtg 3301 gacggacttt ttggttcggg acttaataag ccgttaagtg gcggttttgc ggcagtagtg 3361 aaatatatca atgcatcgcc tgccaccgta gtcgccatcg atatcccctc gggactgatg 3421 ggggaagaga acacatttaa tgtaaaagcc aatatcatcc gtgcccaatt gacattgagc 3481 ctgcaattgc cgaaactggc tttcctcttt gccgaaaatt ccgaattcgt aggcgaatgg 3541 aaactgttgg atatcaacct cagtcgtgaa gcgattgaag aaacggaaag caattatgcc 3601 ttattggaag cggaagaaat acacgctctg atcaaacccc gtaacacttt ctcacacaaa 3661 ggaaactttg ggcatgctct gctgattgcc ggttcgtacg gcatggcagg cgcgtcgata 3721 ctggcagccc gcgcctgtat gcgttcgggt gtaggcttac tgacagtcca tgcacctata 3781 cgcaacaatg atatcctgca gatttcggtt ccggaggcaa ttatcgaatc ggatgccagc 3841 gatacctact ttgcctgccc tacagatacg gatgactatc aggctgtagg aatcggtccg 3901 ggcatcggac gctcggaaga gaccgaagct gcactgcttg aacaactcag tggttgccag 3961 acacctctgg tactggatgc cgatgcacta aacatattgg ccaaccaccg ccacgcactg 4021 accacattgc ccaaaggctc tattctgact ccccatccca aagaactgga acgcatggtg 4081 ggcaaatgcc agaactcata cgaacgactg atgaaggcct gtgaactggc ccgaaccgcc 4141 aaagtacata tcatattaaa aggagcctat tcggcaatta tcaccccctc gggcaagtgc 4201 tatttcaact ctacgggtaa tccgggtatg gcaacagccg gaagcggaga tgtattgaca 4261 ggtgtcgtgc tggctttgct cgcacaggga tatccggctg aagaagctgc caaaatcggt 4321 acttatgtac atggtctggc aggtgatttc gcacgcaaaa agcaaggcgt tatcagcatg 4381 acggcaggag acattatcag taatctgcca ttggcttggc gtctggtaag cgaataaaag 4441 ttaacaactt atgattttcc aaataacttc attaactttg ttttttaaac cagttaaaat 4501 aaaccggaaa tgaaaaagct aattatactg acagggctgt tactctctac ctcggcttat 4561 gcccagaccg aagttacagc gggagttacc cggggaaaag attacggtgt aacctatgca 4621 cttcctaaaa cagcaatcaa tattgaagtc aaagtcaata aagtgacata tactccggga 4681 gaattcagca agtatgccga ccgttatctc cggttgaccg atgtgtcggg tgagcctcag 4741 gaatattggg aactggtcag cgtcaaagca aaatctgtcg gtatccccga tagcgaacat 4801 acctattttg tcaagctgaa agataaaaca gtagctccgc taatagaatt gaccgaagat 4861 ggtatcgtaa aatcaatcaa cgtaccgcta tctcctaaaa aatcggctcc gatgcaaccc 4921 gccacgacac agaaaaagaa gataaatcca cgtgattttc tgaccgaaga gattctgatg 4981 gcaggttcta cggctaaaat ggcggagttg gttgccaaag agatttataa cattcgtgaa 5041 agtaaaaatg ccctggtacg cggacaggca gacaacatgc ccaaagatgg ggagcaactg 5101 aagattatgc ttgccaacct ggaagagcaa gaggctgcca tgaccgaaat gttctcgggt 5161 accttgaata aagacgaaaa gatattcaac atccgcctca ctccggataa ggaaatggac 5221 aacgaagtag ccttccgctt ttcgaagaag ctgggcatag ttgctaataa cgatcttgca 5281 ggagagccgg tttatatcac gctgaagaat ctgaaaaccg tcaacgtacc ggaagacgat 5341 ggcaaaaaga aggtggacgg cattgcctat aatgtgcccg gcaaagcaca agtaacacta 5401 acggagggga aaaagcaatg gtttaacgaa gaacttcctg tcacacaatt cggtactatc 5461 gaatatctgg ctccggcgct tttcaataag aaatcgactg ttcaggttac tttcaacccg 5521 gatacaggag gcttgatcaa ggtagataga gaagaaggag aataaagcat aatcaaaaac 5581 tccggtcgat cttaaatgaa gtgcacccca aaagttcatg tttaactttt agggtgcact 5641 tcatttttaa atcaaccgga gcctctttat tatattccga tagtatatcg taatgcaatc 5701 agttctcaat cactaatttc acaaatccgt ctttctgcaa ctgagtgata taagccgtaa 5761 tacgtgattc gtaattttct tcataattga agtgttctgc cagctcttca ataatccggc 5821 gtacggttct ctttccgtca atcaactccc atacggcagt gccatgatct tccagccgga 5881 catgaatatc cgcagacatt cctttaggca acaagaatcg ccgcatccac tcgtatttaa 5941 accgggggaa agcaatggta acggtaccat cgcttccctt ttcggccgta atattttcac 6001 tacggaaagg aattacatcc agaagattta ttttctcttt cacgtctgcc atatactgtt 6061 attttttgat atttgcttcc tgcagtccgt atcccttctt cttgtcttcc gctttcaaca 6121 ttaaagctac aatcagagcc aaaacaccga aacaagcaaa gatagccata ggcaaagtat 6181 agtcataagt ctgcgctcca tccacaacag gacctttgca ataggtattc aacacccatc 6241 cgatcaacag aggtaccccc atcaatcccc agttctgcac ccagaaaatc aaagcatagg 6301 cagtacccag ttgtttctcc ggaataattt tcggaacaga aggccacatg gccgaaggca 6361 ccagtgaaaa agcaataccc agaacaatca taatcacagt ggcaaaccac catacgttca 6421 gaatgggaag cgcaaacaaa gtatgcacac caatcagcat gacggcaccg ataatcatca 6481 acgtcgctcc cttaccgata cggtcataaa gagtaccaaa caacggagtc aggaagatgg 6541 tacctatcgg tagtaatccc ggaatatttc cggccagctt agggtctacg ttatacttct 6601 gcaccatcaa gtcggttgca tatttaataa aggggaaaac agcagaatag aatagtacac 6661 acaataaagc aatcagccag aagcctttat tggtgacaat cagcataacg tccttcatac 6721 ggaacggttc ttccggttct tctccctgag catctaaaga agcgtcaagt ttcttatcat 6781 aaaaggtata aatgaaaaag gcgatagtac cgatgcacag catgatcagg cacaacaaaa 6841 taggcatcgg aatattggta tggaaactgc cgctttcatc cgtatagccg aaataatcgg 6901 caatgggaac ggtaagcacc atagccaaag tggtaccgat acgtgcggtt gccatctcga 6961 gtcccatagc caaagccatc tctttacctt taaaccattt cacgataatc ttagagacgg 7021 tgataccggc gatctctacg ccgacaccaa agatagcgta tcctaaagcc gccagaaaga 7081 cctgagtctt gaaacccata atcaaagcac cttcagggaa agtagtagag atagcataat 7141 attttagtcc acaacccaac accatcagta tacaagctcc cataccggtg aaacgaactc 7201 ccatcttatc gagaataata ccaccgaaaa tcaacatgag caggaataca ttgaaccatc 7261 cgtaagcact ggtaaagaat ccgtagtcca aactatccca gagaagctct ttctcgagca 7321 taggctttaa aggggacatt acatcggtga ggaaatagcc gcaaagcata gtaaacgcga 7381 ccagagcgag cacactccaa cgaagtgttt tggagtcact caatttgttt ttcaattgtt 7441 ctgtcattgt aatatttaaa ctcagaaatt agtaaaagtg ttattgcgaa caaaggtaac 7501 taaatctgcc ttgtatgcct aacaaaaaga tgcattttac ggcaaaaaat aagcgaagct 7561 gcaagtttcg gtttgaaatt gcagcttcgc ttatcgtttc ttaaaaagaa tctgttgtta 7621 gtttgccgga gtagccggag tttctgtggc aggggcttca accggagcag cagcgtctgt 7681 cttcggtgca gtagtaccta cgggcaggtt ataagggttg gtctgctctt cctgctgtgc 7741 ctgttccata atgacatctt gtgttttaga agaagaagtc ggaacgacat acgcagtagc 7801 aatgctcatc acaaccataa atgcagctaa gccccaagtt gctttttcca gaaagtctgt 7861 agttttgcgt acacccataa tctggttaga tgatgagaac cctgaagcaa gaccaccgcc 7921 ttttgagttc tgaatcaaca caatgaagca catcagtatg gctgcaataa ccattaagat 7981 aactaataat aagtacattt tgttattttg atttagcgtt aataatcaat ttctctaaaa 8041 atctgatttg gtctgcaaag taagcatttt tttttggata tttcaaactt aattttttaa 8101 taatttcaag tgccttggaa tatcgatgct gtttgacgta tattttggcc aatgtttcgg 8161 tgaaacagct atcatcttca tcttcttcat gatgcgtctc gctctcttcc tcttcggaga 8221 tagctttatt ttcatctgcc ggttgcaaac ggatggatgt ttcttcttca cttctttcga 8281 taaagccgtc aatcaattca tgaccgcgaa gtttgggagt ttcttccagt tccggtgtat 8341 cgtcttcttg cagcaaatag gtggtatagt ccgttgcata gtccaggctt gtctgggctg 8401 aaacctcttc gggcacggtg gccagaaaag catcgatcag ggaaagcgta cgatcgaggc 8461 tgggctcttc ctctaaaact tctgtttcgg gaagtgcgtt ctttttccga ggtttcaaaa 8521 tatatcgttc accctcaatc agataaaaca gcttccggcg atcagccaca tgcaatatgg 8581 ctttacgaag ctcggcaccg aaagagatat cgtgcaacaa atatagattt ttaagataga 8641 gtaatcgcag tgactgaaaa taaggatagc gtgtgacaag cgttcgcaac tcgtacaaag 8701 tatctttatt cagcgtttcc ggatgctgaa tccattgttg taagttagca gaaatcattc 8761 taattaccag tttgctaccg ttgcgttaaa tatttgatct gtaatctctt tagtcatctc 8821 cgcaatcagt ccgtcctgaa cggctgtcag caactccctc gaatcataga cacggaaggc 8881 cgagaactgt tgctcgaagt cctgttcatg attcgtattg ttcacaaaac gaacattcac 8941 tgtgatggtc agcttggttt cagaagagta tccgtcggcc gaaacagcct ggttatactg 9001 gttatatccg gtaatctctc catcaatctc gaggtcggca ttattattca ccagtttcag 9061 acgggtctga cgaaggaaaa tgtctttcag gtcctcgttg aacttagtgc ctaacggtgc 9121 ataaacatag tccgacttaa taggaaagtc ggcaatagag atagtcttta ccttatcgta 9181 attgatatta ccaccattaa acttataaga aacagtacac gaaattccta ctaccagtgt 9241 gaaaaccagc agtgaaattc gcattatctt tttattccaa tccatattct tttatttttc 9301 ggtaaagggt acgctcggat atattaagat cctttgccgc gctttttcgt ttgccatgat 9361 gcttttcaag ggctttacgt atcatttctt tctcgacttc gtccaacgaa agcgactctt 9421 ccacatactc ttcggtatct tgtatgtcat cgtcatcggg acaattgggc ttgaccggat 9481 gaatgatggc aggcactgag ggcgtagggg ctactaccgg agccggcgta taaaacgtac 9541 cgacattgga ggttaccgct ccgcgctcgg acatgatttc gtgtacaagc tttttcagtt 9601 cggtcacatc ttgtcgcatg tcaaaaagga cctgatataa gatttcacgt tcactttcga 9661 agctcttccc tgtctttaca ccgaacaggg caggcaatcg ctgcgtactc tgagcaggca 9721 gataagattg caagataggg gcattaatct cacggttagt ctcaattata gagatttgct 9781 ccgtgatatt cttcaactga cgcacattac ccggccagga ataagacagc aaaacccgtt 9841 tggcatcttc ggtcagctgt atggcgggca tacgatactt ctctgcaaag tcacttgcaa 9901 acttacggaa cagtaacagc acatcttctc cacgctcccg caaaggaggg atctggatgg 9961 gcaccgtatt gagacgatag tataaatcct cacggaaacg tccctctgca atggcctggg 10021 tcaaattgac attggtagca gccacaatgc ggacatccgt tttctgtact ttggaggagc 10081 ctacttttat aaactcccca ctctcgagta cacgaagcaa acgtgcctgc gtgggcaaag 10141 gcaattctcc gacttcatcc agaaaaatag ttccgccgtc ggcttcacca aaatagccct 10201 ttcgctcacc gatggctccc gtaaaagccc ctttttcatg accgaacagt tccgaatcga 10261 tggttccttc aggaatagca ccacagttga cagcaatata ctgtccatgc tttcggcgac 10321 tgtattggtg aatgatctga gggaaacttt ccttaccaac accactctct ccggttatta 10381 gcacggacaa atcggtaggt gccacctgta tggcaacatc tatcgcacgc gtcaaagctt 10441 cagtgttacc aataataccg aaccttagtt ttacctgttg tatttccgct tttgtcatat 10501 tcgcactaaa ctcccttcct gattaaatat catcatctac tgtatcgagc ttcagtttat 10561 cactgtcgtc tcgtttctcg taatactgtt tacgtaacgg attggcatgt gcttccttct 10621 cacgttgacg gttacggaat acgtcgatcg ctacataaat agcctgacgg aatgaatctt 10681 cgcaagcaac gccttttcct gcaatatcat aggctgtacc atgcgcggga gaagtgcgta 10741 tcaccggcaa acccgccgtg tagttcacac cttcatccat ggccaatgcc ttgaaaggag 10801 ccaatccctg atcgtgatac atggccagta ctccgtcaaa atgggtgaaa ttgcccgatc 10861 ccataaatcc gtcagccgga taagggccat agcacaagat tcccttggca gccatttcct 10921 gaatagcagg agaaatgatt tcctgttctt ccgtaccgag caatccgtcg tctccggcat 10981 gcggattcag tgccaacact gcgatgcgcg gcgcaccaat cccgaaatcc tgtttcaacg 11041 accggttgaa tatggcaagt ttctcctgaa tcagttcctt ggttattgaa gaggttatct 11101 cacgaaccgg aatatgtcct gttaccaaag ctacccggaa atcctctttc atcaggatca 11161 tcagtgattt tgaaccattc cccagacgtt gttcgatata ttccgtatgt ccgggaaaag 11221 caaatccttc ggactgaatc gtatgcttat tgataggagc cgtcactatg acatcgatca 11281 agccttccct gaactcctct atcgccttct caagtgctcc caaagctgct ttaccggctt 11341 ccggatcggg ttttgagaac tctactttca cctcgtcatc cgtacagttg accacgctca 11401 ggcgattgtg ggcagcttct gcagcggtat tgacaatact gaagttagta ggcaaatcga 11461 gcgacttgcg gtgatatgca gccactttcg gagagccgta aatgaccggt gtacagagtt 11521 ccaacatgac ggggtcggca aacgttttta aaatgacttc gtatcctacc ccgtttatgt 11581 ctccctgagt gatgccaatt tttattttgt tatcttccat tttgttattt gttagttttc 11641 tcctcctgct ctatgcccat cggaatctgt tcctgcgcct tctcggtagg aagttgcaaa 11701 gtatacagag atgcttccaa tcggcgcatc aggtcacgtt tcattttatc gggtgagtaa 11761 ataaatactt ctgtagtgat aatacggtgg ctggctttat ccagacgggt gtgcgaaaca 11821 aacgggccac ccatgaaatc gccctttatg cgccacagtc cgcgtgcttc cattgtgtaa 11881 tctccatgaa tatcaatcgg acgaacctct acggtagacg aatcagtcgc catgtacata 11941 ccctctttgg cacccggaat attagccttc atcactgaat cgcgcttatg gataaagaac 12001 tctttcgtaa aggtatcctt atctgtatac gggtaagagt agattacaaa gttctggtct 12061 ccggtagcgg cattagtacc tgcccagaaa aagtcttctc ctgtcttcga actgctcagt 12121 tcggccggaa gccagatatc actgttgaac atgctaccta ctttcgttga aatatagtca 12181 ttatgatttt tctccaggaa agagatctga cggttcattt cggcacgggt aaagaagtct 12241 ataatcggct gtttgttctc ttcgacaaac ttctcaaatg atgcctcgtc cggagcctga 12301 atagtcaaaa tcatctgggg agatgcatat acatccttgg catacttgaa tttaggttgg 12361 gtataaatgt cctgtatatc tacgataata atgttgcgca ccaacttcag gatggcatca 12421 aaatctttgg gagaagtaga catgatcctg aacgaacgtt ccgattgcgg aagtccgggc 12481 acatctgtat caagcacatt gtacaaagct ctaccggcag gacgctccca cacaggcttc 12541 tcaaccacaa cgaggacttc ataagcacgt ccgctggaag ttggagtaaa cacactcttc 12601 ttgccgcttt tacaagaaaa caacactact gctacaagag ccatactgag gtaaaacagg 12661 tactttttca tatgcatcaa ttttaatgtt ttcacaaatc tacgaaatgg tcgtatactt 12721 tcatccaatg tgctgataat ttatattaat tcttgttact ctcctcctgt ttagccgtcg 12781 ataacatccc gcaagcggca aaaatatctt ctccccggga agctcgaatg gtagtgaaca 12841 gtccatgtga ggtcaggtag tcacgaaatg acgtcatagc ctccataccg gcaccctcga 12901 ggtctacccc aggaatggca tgaaaccgga ttaagttcac ccggcagtca agcccacgca 12961 gcaatttcaa cagctcctta gcataaatca gcgaatcatt gacgccctta aaaacaatgt 13021 attcaaacga aagtctgcgc tgtttactaa aatcatagtt ttttaacaga tcgaccattt 13081 ctttaatcga gaaagccctt tcggccggca tcagctcaga acgttgtgaa ggaaaaggag 13141 aatgcaggct gatagccaga tgacattcgc tttcttcaat aaagcgttga agtcctttcc 13201 gcaatcctac agacgacaaa gtaatacgct tggggctcca tccgtatcca tacgaagcgg 13261 tcaggatatg cagtgctttt aatacttcat ccaaattatc gagaggctcg cccatcccca 13321 tcatcacgac attagtcaac ttatcccgct ctggcaatgc tgcgatttga ttcaagatct 13381 gattggctgt cagacttgcg gtaaatcctt gtttacccgt catgcagaac ttacagttca 13441 ttttacagcc tacctgagaa gacacgcaca atgtcgcccg atcctcgtcc ggaatataca 13501 ccgcttcaac aaaatgattg tcactcacct gataaagata cttcaccgta ccatctacgg 13561 aacgcatctc atcaacaggc gcggatatcc ccaaatcata ctctcccttg agcaactctc 13621 tatgcttcaa cgacagattg gtcatttcat caatagaagt cactttttta tcgtataacc 13681 aggaagcgat ctgtttggct gcaaaagcag gcatccccaa atctttggtg acagattgca 13741 attcggtaag ggtcattcct aaaagcggat atttgggcat atttactaca aatatttatt 13801 tattcatgca aatgtaagga ataaaagtcg attttaaaaa agagaaggga caaaagttaa 13861 taggaagagg gaaagagata gcaaaaagaa aggccgttcc gtgcggaaca gcctttcgta 13921 tattaaaacg acgttatcta aaaaaacaaa tccgttttta gaagaacagg tatcgtttat 13981 cttttacatc gcctttcaga taaagatcgt tcataaaacg acttgccaga cgggcatgca 14041 tgttttccaa tgtagcctct tctgattggg catcgaatgt ttcgttcagc ttatctttgg 14101 catatacctg caacacaaac acaccgccat tacccttgat aggagcgctc agcttattga 14161 tatccgaaac cgaagcgtat gcgcctacca gcggctcact actacgcaaa gcggctacat 14221 aagcaggcgc tgcaaatgtt acgtgtttta cagaatcact tactgcattg gccatcgatg 14281 tgtactgggc aattgtagtt gcattggcag ccttcatgtc ggccatgatc ttctcagctt 14341 tcttatcacg aatgatttca gctctcaact gatcctgaac ctgggccaaa ggacgataac 14401 cttcttcgat cacgctaacc agaccaacaa ccaacatgcg gtcgctttcg ccacattcat 14461 ataagccgga aacttcaccc ggttttgcag caaaggccca tttcagtgct tctttagtcc 14521 ctctgatacc accgattccg tgttctgagc tatacagatc atttctttcg agcaatttat 14581 agcctgattc ttcagcattg gccgcaacct tgtctactgt cgggttagct gcaataaact 14641 ggctgaattc attataagct ttattataag tttctttgct gaactcaact gcacgcttga 14701 taacggcaac tttatattta tctttcacag ctttcttgtc agtcacctgc aaaatgatat 14761 tgccttgtcc caatgctacg ttagagagtt cgtttactcc cagattgttg atagtgctga 14821 taaatttcaa gttatcgcca tcaacctgtg cattttcgta gttagcagac gaaatccagt 14881 tggattcacc tgtttgtccg tacttcttag ccagagctgt aaagtcggcc ccacccttaa 14941 tagcagtata gatgctgtca gccaaagctt ttgttttagc agcgtcttct gtgtaaacct 15001 gaatctgacg gaactgtaca gaatcggcag cagccacttt agacaacacc ttgaacgaat 15061 tgatagtatt gtcgcctgca ttgtagtaag ggccatatac ttgtccaatc gaagctgaat 15121 ccatgcgtgc aactacatct gacgggaaag ctttcttggt atagtacaaa tcaacatacg 15181 gatattccga tccggtagaa cggatgaaag tagtataatc accattggca gtagccagtt 15241 ggtttgtata atcagtcact tcctgctgga tagcagctct gtcttctgca ctggctgtca 15301 cctgtacatc gatgtatttg atgttgcgtg tttcaacata ttgtttgaac tgttctttct 15361 tcttgttata gagatctttc agttcagact ctttcactgt gatagtagag tctacaatag 15421 aagaataagg aacagcagcc aacagaatat ccgactggtt tactcttgcg tcgaatgcat 15481 cctgtgcttc aaccggatta gagaaaagag ctttagtcac cagtgcctgg tatttttccg 15541 ccaaacggct ctggatcagt gtcttttcta caaatgacca aagtttgtgc attccttcat 15601 agtattccac atattgagac ggcatcttgg tcttgtccat tttagagtag tcagccaaga 15661 atttcttcaa catatcttta tcgaaagcgc ccgtttgagg attgcggaac ggagtctgct 15721 gcagcaacgg attcacacct tcgttaatga ttgattgaat ttcagccttc gaaacagtaa 15781 taccgagctt cttcgcttct ttttcaatca gtttattgtt cacatagcta cgccatactt 15841 cgtctttcac ctgattggtc tgttcatcat tcaatgaact cattccgctt gagaacttga 15901 taacctcggt atattcttct accatgttct ggtagtcctg agcagaaaga gtttctccat 15961 tgacttcgcc tacatcatgc gattggtgtg gctggagaac tttccaggca tcgcccgcaa 16021 tgaaagcaaa caaagccaaa ccaataacga tc //