LOCUS       gnlProkkaOBCJLMGD_406  16052 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|OBCJLMGD_406.
ACCESSION   gnlProkkaOBCJLMGD_406
VERSION     gnlProkkaOBCJLMGD_406
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-30 19:20:55
            Original ID  :: gnl|Prokka|OBCJLMGD_406
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16052
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16052
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[5698:6052]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5699..6052
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..16052
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..16052
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             complement(268..453)
                     /locus_tag="ctg292_1"
                     /transl_table=11
                     /translation="MLTSYSSLIKILLFDNQLLIFWMHSVVKFFSYVQDVRSCLFIKLP
                     LRLSIACLSTYFHILL"
     CDS             complement(601..1236)
                     /NRPS_PKS="Domain: oMT (51-151). E-value: 4.4e-15. Score:
                     46.5. Matches aSDomain: nrpspksdomains_ctg292_2_oMT.1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089:methyltransferase (Score: 99.4; E-value:
                     3.7e-30)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg292_2"
                     /transl_table=11
                     /translation="MNKRGFVSKILQNFRKPEGFFGRMILWGMNTGHASLAQWGMSCLQ
                     WQPEWSVLDIGCGGGANLLQILQRCPQGKAYGIDISSESVTFARKKNKKYLGTRCFIEQ
                     GGVHRLPYPDYAFDAVTAFETVYFWGNLQHAFTEVARVLKPGGSFLICCEISDPANKAW
                     TGLVEGMEIHSCDELKAILSKSGFTDTAIFRTKKEELCLVSHRQTVRL"
     aSDomain        complement(784..1083)
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg292_2_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="4.40E-15"
                     /label="ctg292_2_oMT.1"
                     /locus_tag="ctg292_2"
                     /protein_end="151"
                     /protein_start="51"
                     /score="46.5"
                     /tool="antismash"
                     /translation="VLDIGCGGGANLLQILQRCPQGKAYGIDISSESVTFARKKNKKYL
                     GTRCFIEQGGVHRLPYPDYAFDAVTAFETVYFWGNLQHAFTEVARVLKPGGSFLI"
     CDS             1542..2882
                     /locus_tag="ctg292_3"
                     /transl_table=11
                     /translation="MNNVQQVKTYSQRKISDFLFILWAGGAALLSYSLVYALRKPYTAA
                     GFDGLEAFGMDYKVVVTIAQILGYVLSKFIGIKLISELKRENRMKFILISIILAEASLI
                     LFGLLPAPYNTGAMFLNGLSLGCMWGIIFSFIEGRRMTDILASLLGVSMVISSGTAKSA
                     GLYVMDTLNISEFWMPALIGGVALPLLALLGYALNRLPQPTAEDIAIKSKRETLNGKQR
                     WELFKNFMPFLTLLFIANVVLTILRDIKEDFLVKIIDVSQYSSWMFAQVDSVVTLIILI
                     IFGLMVFVRSNLKALSILLGLIIASMVVMAVVSFGYEQLQLNAIVWLFIQSLCLYLAFL
                     TFQTIFFDRFIACFKIRGNVGFFIAMNDFLGYTGTVIVLAVKEFFSPDINWTAFYNLMA
                     GYVGIICFVAFVCSFIYLHQRYRRENYGKTGVFRKKEEEKEVPDFVY"
     CDS             3127..4437
                     /locus_tag="ctg292_4"
                     /transl_table=11
                     /translation="MLAEKEYKVEAYLFNPKGELSADCQTNKELVEMMDNVKFSEVSTQ
                     FVPPALTMDHLVVDGLFGSGLNKPLSGGFAAVVKYINASPATVVAIDIPSGLMGEENTF
                     NVKANIIRAQLTLSLQLPKLAFLFAENSEFVGEWKLLDINLSREAIEETESNYALLEAE
                     EIHALIKPRNTFSHKGNFGHALLIAGSYGMAGASILAARACMRSGVGLLTVHAPIRNND
                     ILQISVPEAIIESDASDTYFACPTDTDDYQAVGIGPGIGRSEETEAALLEQLSGCQTPL
                     VLDADALNILANHRHALTTLPKGSILTPHPKELERMVGKCQNSYERLMKACELARTAKV
                     HIILKGAYSAIITPSGKCYFNSTGNPGMATAGSGDVLTGVVLALLAQGYPAEEAAKIGT
                     YVHGLAGDFARKKQGVISMTAGDIISNLPLAWRLVSE"
     CDS             4510..5565
                     /locus_tag="ctg292_5"
                     /transl_table=11
                     /translation="MKKLIILTGLLLSTSAYAQTEVTAGVTRGKDYGVTYALPKTAINI
                     EVKVNKVTYTPGEFSKYADRYLRLTDVSGEPQEYWELVSVKAKSVGIPDSEHTYFVKLK
                     DKTVAPLIELTEDGIVKSINVPLSPKKSAPMQPATTQKKKINPRDFLTEEILMAGSTAK
                     MAELVAKEIYNIRESKNALVRGQADNMPKDGEQLKIMLANLEEQEAAMTEMFSGTLNKD
                     EKIFNIRLTPDKEMDNEVAFRFSKKLGIVANNDLAGEPVYITLKNLKTVNVPEDDGKKK
                     VDGIAYNVPGKAQVTLTEGKKQWFNEELPVTQFGTIEYLAPALFNKKSTVQVTFNPDTG
                     GLIKVDREEGE"
     CDS             complement(5699..6052)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg292_6"
                     /sec_met_domain="PF05402 (E-value: 3.1e-17, bitscore: 53.2,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="PqqD_RRE (E-value: 4.4e-10, bitscore:
                     29.8, seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADVKEKINLLDVIPFRSENITAEKGSDGTVTIAFPRFKYEWMRR
                     FLLPKGMSADIHVRLEDHGTAVWELIDGKRTVRRIIEELAEHFNYEENYESRITAYITQ
                     LQKDGFVKLVIEN"
     CDS             complement(6059..7321)
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 82.1; E-value: 5.1e-25)"
                     /gene_kind="transport"
                     /locus_tag="ctg292_7"
                     /transl_table=11
                     /translation="MLEKELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFT
                     GMGACILMVLGCGLKYYAISTTFPEGALIMGFKTQVFLAALGYAIFGVGVEIAGITVSK
                     IIVKWFKGKEMALAMGLEMATARIGTTLAMVLTVPIADYFGYTDESGSFHTNIPMPILL
                     CLIMLCIGTIAFFIYTFYDKKLDASLDAQGEEPEEPFRMKDVMLIVTNKGFWLIALLCV
                     LFYSAVFPFIKYATDLMVQKYNVDPKLAGNIPGLLPIGTIFLTPLFGTLYDRIGKGATL
                     MIIGAVMLIGVHTLFALPILNVWWFATVIMIVLGIAFSLVPSAMWPSVPKIIPEKQLGT
                     AYALIFWVQNWGLMGVPLLIGWVLNTYCKGPVVDGAQTYDYTLPMAIFACFGVLALIVA
                     LMLKAEDKKKGYGLQEANIKK"
     CDS             complement(7618..7878)
                     /locus_tag="ctg292_8"
                     /transl_table=11
                     /translation="MGVRKTTDFLEKATWGLAAFMVVMSIATAYVVPTSSSKTQDVIME
                     QAQQEEQTNPYNLPVGTTAPKTDAAAPVEAPATETPATPAN"
     CDS             complement(8003..8758)
                     /locus_tag="ctg292_9"
                     /transl_table=11
                     /translation="MISANLQQWIQHPETLNKDTLYELRTLVTRYPYFQSLRLLYLKNL
                     YLLHDISFGAELRKAILHVADRRKLFYLIEGERYILKPRKKNALPETEVLEEEPSLDRT
                     LSLIDAFLATVPEEVSAQTSLDYATDYTTYLLQEDDTPELEETPKLRGHELIDGFIERS
                     EEETSIRLQPADENKAISEEEESETHHEEDEDDSCFTETLAKIYVKQHRYSKALEIIKK
                     LSLKYPKKNAYFADQIRFLEKLIINAKSK"
     CDS             complement(8764..9285)
                     /locus_tag="ctg292_10"
                     /transl_table=11
                     /translation="MDWNKKIMRISLLVFTLVVGISCTVSYKFNGGNINYDKVKTISIA
                     DFPIKSDYVYAPLGTKFNEDLKDIFLRQTRLKLVNNNADLEIDGEITGYNQYNQAVSAD
                     GYSSETKLTITVNVRFVNNTNHEQDFEQQFSAFRVYDSRELLTAVQDGLIAEMTKEITD
                     QIFNATVANW"
     CDS             complement(9272..10498)
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 389.6; E-value:
                     3.4e-118)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg292_11"
                     /transl_table=11
                     /translation="MTKAEIQQVKLRFGIIGNTEALTRAIDVAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EADGGTIFLDEVGELPLPTQARLLRVLESGEFIKVGSSKVQKTDVRIVAATNVNLTQAI
                     AEGRFREDLYYRLNTVPIQIPPLRERGEDVLLLFRKFASDFAEKYRMPAIQLTEDAKRV
                     LLSYSWPGNVRQLKNITEQISIIETNREINAPILQSYLPAQSTQRLPALFGVKTGKSFE
                     SEREILYQVLFDMRQDVTELKKLVHEIMSERGAVTSNVGTFYTPAPVVAPTPSVPAIIH
                     PVKPNCPDDDDIQDTEEYVEESLSLDEVEKEMIRKALEKHHGKRKSAAKDLNISERTLY
                     RKIKEYGLE"
     CDS             complement(10523..11620)
                     /locus_tag="ctg292_12"
                     /transl_table=11
                     /translation="MEDNKIKIGITQGDINGVGYEVILKTFADPVMLELCTPVIYGSPK
                     VAAYHRKSLDLPTNFSIVNTAAEAAHNRLSVVNCTDDEVKVEFSKPDPEAGKAALGALE
                     KAIEEFREGLIDVIVTAPINKHTIQSEGFAFPGHTEYIEQRLGNGSKSLMILMKEDFRV
                     ALVTGHIPVREITSSITKELIQEKLAIFNRSLKQDFGIGAPRIAVLALNPHAGDDGLLG
                     TEEQEIISPAIQEMAAKGILCYGPYPADGFMGSGNFTHFDGVLAMYHDQGLAPFKALAM
                     DEGVNYTAGLPVIRTSPAHGTAYDIAGKGVACEDSFRQAIYVAIDVFRNRQREKEAHAN
                     PLRKQYYEKRDDSDKLKLDTVDDDI"
     CDS             complement(11625..11972)
                     /locus_tag="ctg292_13"
                     /transl_table=11
                     /translation="MKANIPGAKEGMYMATDSSTVEVRPIDIHGDYTMEARGLWRIKGD
                     FMGGPFVSHTRLDKASHRIITTEVFIYSPDKMKRDLMRRLEASLYTLQLPTEKAQEQIP
                     MGIEQEEKTNK"
     CDS             complement(12746..13423)
                     /locus_tag="ctg292_14"
                     /transl_table=11
                     /translation="MTGKQGFTASLTANQILNQIAALPERDKLTNVVMMGMGEPLDNLD
                     EVLKALHILTASYGYGWSPKRITLSSVGLRKGLQRFIEESECHLAISLHSPFPSQRSEL
                     MPAERAFSIKEMVDLLKNYDFSKQRRLSFEYIVFKGVNDSLIYAKELLKLLRGLDCRVN
                     LIRFHAIPGVDLEGAGMEAMTSFRDYLTSHGLFTTIRASRGEDIFAACGMLSTAKQEES
                     NKN"
ORIGIN
        1 ataatcgggt acagaaaaag tattcgcacc ggatttgaat actatccgat acgttgaatt
       61 attttatttt aaacatatat cggacataaa gaaaagtata tttgtccgcc tatatattta
      121 cgggtgcaaa ggtaaaacct tcttttgagt ctccaaaact tttcacaggt tattttcatc
      181 ataggaagtt atatgactga atatcaaaga tataatttat ctctttgcaa ataaggaaag
      241 cagcaatata cataatacta atgtggctta taaaagaatg tggaaataag tggagaggca
      301 ggctatggag agtcttaacg gtaacttgat aaacagacaa ctacgcacat cttgaacgta
      361 agaaaagaat tttacgacag aatgcatcca gaatataagc aattgattat caaacaataa
      421 tatcttaata agagaactgt aggaagttaa cattaacagt acgttaatat taacttcgta
      481 attgcaagat attaattctt tagagatacg aagttaataa gctattgata aggagggaaa
      541 gcacttttac gggcattaac attgttaacg tattcgttgg taagagcgtc ccggcattgg
      601 ttacaaccgc acagtttgcc gatggcttac caggcacagt tcttctttct tcgtccggaa
      661 tatggccgtg tcggtaaaac cacttttgga aagaatcgcc ttcagttcat cacaggaatg
      721 aatctccatc ccttcaacaa gtcccgtcca agccttattg gcaggatcgc ttatctcaca
      781 acagataaga aaagatccac cgggctttaa cacacgcgcc acttccgtaa aagcatgctg
      841 caggttaccc cagaagtaga cagtctcgaa agcagtgacc gcatcgaacg cataatcagg
      901 atagggaagt cggtggactc ctccctgctc gataaagcag cgtgtaccga gatacttttt
      961 atttttttta cgcgcaaagg tgacactctc cgatgaaata tctatgccat acgctttccc
     1021 ttgcgggcaa cgttgcaata tctgtagcaa attggcacca ccaccgcaac cgatgtcgag
     1081 tacactccat tccggttgcc attgcaagca tgacattccc cattgcgcca atgatgcatg
     1141 tcctgtattc atcccccaaa gtatcattct tccgaaaaaa ccttcaggct tccggaaatt
     1201 ctgtaagatc ttgcttacaa agcctctctt attcatttgt ctgctgattt aatatttcag
     1261 gcaaaagtac agtttctgcc caaacaagca atacccagaa atagggaatt tatttcctaa
     1321 aagatatttg caggtatgca tctgcttccc gttaaaatta tgacgaacag atgcccggag
     1381 gtgcgatgct cttttcgttt ccgtttcata aatattacat aaacattaca acataacaga
     1441 ttcattatca atatctatta ataataaaca ttcatatatt cagtaacagg tctgtaacac
     1501 taccctccta tttttgcacc ggaaaacaac aagcagatgt tatgaacaat gtacagcaag
     1561 taaaaactta ttcgcagaga aaaatttctg atttcctttt cattctttgg gcaggcggag
     1621 cagcgctgct ctcctattca ttggtatatg cactgagaaa gccttacaca gcagccggat
     1681 ttgacggact tgaagcgttt ggaatggact acaaagtggt agttaccatc gcacaaatat
     1741 taggatatgt actttctaaa ttcatcggaa ttaaattaat ctccgaattg aaacgggaaa
     1801 accggatgaa gtttattctg atctccataa ttctggctga agcttcgtta atattgttcg
     1861 gactgttgcc cgcaccttat aatacaggag ccatgtttct gaacggactt tcactgggat
     1921 gtatgtgggg aatcattttt agctttatcg agggaagacg aatgacggac attcttgcca
     1981 gcttactcgg agtcagtatg gtcatcagct cgggtaccgc caagtcggcc ggtttgtatg
     2041 tcatggacac tttgaacatc agcgaattct ggatgcctgc cctgataggc ggagttgccc
     2101 ttcctctact tgccttgttg ggatatgcac tcaaccggct tccacagcca acagccgaag
     2161 acattgccat aaaatcgaaa cgggaaacac tgaacggcaa gcaacgatgg gagctattta
     2221 agaatttcat gcctttcctc actctgctct ttatagctaa tgtggtactg actatcttga
     2281 gagatataaa ggaggacttc ctggtaaaaa ttatcgatgt ctctcaatac tcttcgtgga
     2341 tgtttgcaca ggtagacagc gtagtaaccc tcattattct gataattttc ggattaatgg
     2401 tgttcgtcag aagcaacttg aaagcactgt cgatattact gggattgatc attgccagca
     2461 tggtagtgat ggcagtcgtt tcgtttggtt acgaacaatt gcagctgaac gccatcgtct
     2521 ggctattcat ccagagcctg tgtctctatc tggcttttct cactttccag actatcttct
     2581 tcgaccgttt tatcgcttgc ttcaaaattc gaggtaacgt gggtttcttc attgctatga
     2641 atgattttct gggctatacg ggaacagtca tagtattggc tgtcaaagaa ttcttttcac
     2701 cggacattaa ctggacagct ttctacaatc tgatggcagg atatgtggga ataatctgtt
     2761 tcgttgcttt tgtatgctct ttcatctacc tgcaccaacg ctaccgcagg gagaattacg
     2821 gaaagacagg ggtattcaga aaaaaagaag aagaaaaaga agttcccgat ttcgtatatt
     2881 aattgctatc tttgtgggtc aaaaaactta aaatgaaagt tcaccatgaa gatttttcca
     2941 agtagcagca tcaagaaact ggatgcttac accatagaac atgaaccgat tgcatcgatc
     3001 gacctgatgg agcgggccgc acaggcactg accaaagcca tcaccgaacg ctgggacatc
     3061 acaactcccg tcacggtatt tgccggaccg ggcaacaatg gcggagatgc ccttgccgta
     3121 gcccgaatgt tggcggaaaa ggaatacaag gtcgaagcct atctgtttaa cccgaaaggg
     3181 gaactgtctg ccgactgcca gaccaacaag gagctggtag agatgatgga taatgtgaag
     3241 ttcagcgaag taagcacaca gtttgtacct cctgccctga caatggatca tctggtagtg
     3301 gacggacttt ttggttcggg acttaataag ccgttaagtg gcggttttgc ggcagtagtg
     3361 aaatatatca atgcatcgcc tgccaccgta gtcgccatcg atatcccctc gggactgatg
     3421 ggggaagaga acacatttaa tgtaaaagcc aatatcatcc gtgcccaatt gacattgagc
     3481 ctgcaattgc cgaaactggc tttcctcttt gccgaaaatt ccgaattcgt aggcgaatgg
     3541 aaactgttgg atatcaacct cagtcgtgaa gcgattgaag aaacggaaag caattatgcc
     3601 ttattggaag cggaagaaat acacgctctg atcaaacccc gtaacacttt ctcacacaaa
     3661 ggaaactttg ggcatgctct gctgattgcc ggttcgtacg gcatggcagg cgcgtcgata
     3721 ctggcagccc gcgcctgtat gcgttcgggt gtaggcttac tgacagtcca tgcacctata
     3781 cgcaacaatg atatcctgca gatttcggtt ccggaggcaa ttatcgaatc ggatgccagc
     3841 gatacctact ttgcctgccc tacagatacg gatgactatc aggctgtagg aatcggtccg
     3901 ggcatcggac gctcggaaga gaccgaagct gcactgcttg aacaactcag tggttgccag
     3961 acacctctgg tactggatgc cgatgcacta aacatattgg ccaaccaccg ccacgcactg
     4021 accacattgc ccaaaggctc tattctgact ccccatccca aagaactgga acgcatggtg
     4081 ggcaaatgcc agaactcata cgaacgactg atgaaggcct gtgaactggc ccgaaccgcc
     4141 aaagtacata tcatattaaa aggagcctat tcggcaatta tcaccccctc gggcaagtgc
     4201 tatttcaact ctacgggtaa tccgggtatg gcaacagccg gaagcggaga tgtattgaca
     4261 ggtgtcgtgc tggctttgct cgcacaggga tatccggctg aagaagctgc caaaatcggt
     4321 acttatgtac atggtctggc aggtgatttc gcacgcaaaa agcaaggcgt tatcagcatg
     4381 acggcaggag acattatcag taatctgcca ttggcttggc gtctggtaag cgaataaaag
     4441 ttaacaactt atgattttcc aaataacttc attaactttg ttttttaaac cagttaaaat
     4501 aaaccggaaa tgaaaaagct aattatactg acagggctgt tactctctac ctcggcttat
     4561 gcccagaccg aagttacagc gggagttacc cggggaaaag attacggtgt aacctatgca
     4621 cttcctaaaa cagcaatcaa tattgaagtc aaagtcaata aagtgacata tactccggga
     4681 gaattcagca agtatgccga ccgttatctc cggttgaccg atgtgtcggg tgagcctcag
     4741 gaatattggg aactggtcag cgtcaaagca aaatctgtcg gtatccccga tagcgaacat
     4801 acctattttg tcaagctgaa agataaaaca gtagctccgc taatagaatt gaccgaagat
     4861 ggtatcgtaa aatcaatcaa cgtaccgcta tctcctaaaa aatcggctcc gatgcaaccc
     4921 gccacgacac agaaaaagaa gataaatcca cgtgattttc tgaccgaaga gattctgatg
     4981 gcaggttcta cggctaaaat ggcggagttg gttgccaaag agatttataa cattcgtgaa
     5041 agtaaaaatg ccctggtacg cggacaggca gacaacatgc ccaaagatgg ggagcaactg
     5101 aagattatgc ttgccaacct ggaagagcaa gaggctgcca tgaccgaaat gttctcgggt
     5161 accttgaata aagacgaaaa gatattcaac atccgcctca ctccggataa ggaaatggac
     5221 aacgaagtag ccttccgctt ttcgaagaag ctgggcatag ttgctaataa cgatcttgca
     5281 ggagagccgg tttatatcac gctgaagaat ctgaaaaccg tcaacgtacc ggaagacgat
     5341 ggcaaaaaga aggtggacgg cattgcctat aatgtgcccg gcaaagcaca agtaacacta
     5401 acggagggga aaaagcaatg gtttaacgaa gaacttcctg tcacacaatt cggtactatc
     5461 gaatatctgg ctccggcgct tttcaataag aaatcgactg ttcaggttac tttcaacccg
     5521 gatacaggag gcttgatcaa ggtagataga gaagaaggag aataaagcat aatcaaaaac
     5581 tccggtcgat cttaaatgaa gtgcacccca aaagttcatg tttaactttt agggtgcact
     5641 tcatttttaa atcaaccgga gcctctttat tatattccga tagtatatcg taatgcaatc
     5701 agttctcaat cactaatttc acaaatccgt ctttctgcaa ctgagtgata taagccgtaa
     5761 tacgtgattc gtaattttct tcataattga agtgttctgc cagctcttca ataatccggc
     5821 gtacggttct ctttccgtca atcaactccc atacggcagt gccatgatct tccagccgga
     5881 catgaatatc cgcagacatt cctttaggca acaagaatcg ccgcatccac tcgtatttaa
     5941 accgggggaa agcaatggta acggtaccat cgcttccctt ttcggccgta atattttcac
     6001 tacggaaagg aattacatcc agaagattta ttttctcttt cacgtctgcc atatactgtt
     6061 attttttgat atttgcttcc tgcagtccgt atcccttctt cttgtcttcc gctttcaaca
     6121 ttaaagctac aatcagagcc aaaacaccga aacaagcaaa gatagccata ggcaaagtat
     6181 agtcataagt ctgcgctcca tccacaacag gacctttgca ataggtattc aacacccatc
     6241 cgatcaacag aggtaccccc atcaatcccc agttctgcac ccagaaaatc aaagcatagg
     6301 cagtacccag ttgtttctcc ggaataattt tcggaacaga aggccacatg gccgaaggca
     6361 ccagtgaaaa agcaataccc agaacaatca taatcacagt ggcaaaccac catacgttca
     6421 gaatgggaag cgcaaacaaa gtatgcacac caatcagcat gacggcaccg ataatcatca
     6481 acgtcgctcc cttaccgata cggtcataaa gagtaccaaa caacggagtc aggaagatgg
     6541 tacctatcgg tagtaatccc ggaatatttc cggccagctt agggtctacg ttatacttct
     6601 gcaccatcaa gtcggttgca tatttaataa aggggaaaac agcagaatag aatagtacac
     6661 acaataaagc aatcagccag aagcctttat tggtgacaat cagcataacg tccttcatac
     6721 ggaacggttc ttccggttct tctccctgag catctaaaga agcgtcaagt ttcttatcat
     6781 aaaaggtata aatgaaaaag gcgatagtac cgatgcacag catgatcagg cacaacaaaa
     6841 taggcatcgg aatattggta tggaaactgc cgctttcatc cgtatagccg aaataatcgg
     6901 caatgggaac ggtaagcacc atagccaaag tggtaccgat acgtgcggtt gccatctcga
     6961 gtcccatagc caaagccatc tctttacctt taaaccattt cacgataatc ttagagacgg
     7021 tgataccggc gatctctacg ccgacaccaa agatagcgta tcctaaagcc gccagaaaga
     7081 cctgagtctt gaaacccata atcaaagcac cttcagggaa agtagtagag atagcataat
     7141 attttagtcc acaacccaac accatcagta tacaagctcc cataccggtg aaacgaactc
     7201 ccatcttatc gagaataata ccaccgaaaa tcaacatgag caggaataca ttgaaccatc
     7261 cgtaagcact ggtaaagaat ccgtagtcca aactatccca gagaagctct ttctcgagca
     7321 taggctttaa aggggacatt acatcggtga ggaaatagcc gcaaagcata gtaaacgcga
     7381 ccagagcgag cacactccaa cgaagtgttt tggagtcact caatttgttt ttcaattgtt
     7441 ctgtcattgt aatatttaaa ctcagaaatt agtaaaagtg ttattgcgaa caaaggtaac
     7501 taaatctgcc ttgtatgcct aacaaaaaga tgcattttac ggcaaaaaat aagcgaagct
     7561 gcaagtttcg gtttgaaatt gcagcttcgc ttatcgtttc ttaaaaagaa tctgttgtta
     7621 gtttgccgga gtagccggag tttctgtggc aggggcttca accggagcag cagcgtctgt
     7681 cttcggtgca gtagtaccta cgggcaggtt ataagggttg gtctgctctt cctgctgtgc
     7741 ctgttccata atgacatctt gtgttttaga agaagaagtc ggaacgacat acgcagtagc
     7801 aatgctcatc acaaccataa atgcagctaa gccccaagtt gctttttcca gaaagtctgt
     7861 agttttgcgt acacccataa tctggttaga tgatgagaac cctgaagcaa gaccaccgcc
     7921 ttttgagttc tgaatcaaca caatgaagca catcagtatg gctgcaataa ccattaagat
     7981 aactaataat aagtacattt tgttattttg atttagcgtt aataatcaat ttctctaaaa
     8041 atctgatttg gtctgcaaag taagcatttt tttttggata tttcaaactt aattttttaa
     8101 taatttcaag tgccttggaa tatcgatgct gtttgacgta tattttggcc aatgtttcgg
     8161 tgaaacagct atcatcttca tcttcttcat gatgcgtctc gctctcttcc tcttcggaga
     8221 tagctttatt ttcatctgcc ggttgcaaac ggatggatgt ttcttcttca cttctttcga
     8281 taaagccgtc aatcaattca tgaccgcgaa gtttgggagt ttcttccagt tccggtgtat
     8341 cgtcttcttg cagcaaatag gtggtatagt ccgttgcata gtccaggctt gtctgggctg
     8401 aaacctcttc gggcacggtg gccagaaaag catcgatcag ggaaagcgta cgatcgaggc
     8461 tgggctcttc ctctaaaact tctgtttcgg gaagtgcgtt ctttttccga ggtttcaaaa
     8521 tatatcgttc accctcaatc agataaaaca gcttccggcg atcagccaca tgcaatatgg
     8581 ctttacgaag ctcggcaccg aaagagatat cgtgcaacaa atatagattt ttaagataga
     8641 gtaatcgcag tgactgaaaa taaggatagc gtgtgacaag cgttcgcaac tcgtacaaag
     8701 tatctttatt cagcgtttcc ggatgctgaa tccattgttg taagttagca gaaatcattc
     8761 taattaccag tttgctaccg ttgcgttaaa tatttgatct gtaatctctt tagtcatctc
     8821 cgcaatcagt ccgtcctgaa cggctgtcag caactccctc gaatcataga cacggaaggc
     8881 cgagaactgt tgctcgaagt cctgttcatg attcgtattg ttcacaaaac gaacattcac
     8941 tgtgatggtc agcttggttt cagaagagta tccgtcggcc gaaacagcct ggttatactg
     9001 gttatatccg gtaatctctc catcaatctc gaggtcggca ttattattca ccagtttcag
     9061 acgggtctga cgaaggaaaa tgtctttcag gtcctcgttg aacttagtgc ctaacggtgc
     9121 ataaacatag tccgacttaa taggaaagtc ggcaatagag atagtcttta ccttatcgta
     9181 attgatatta ccaccattaa acttataaga aacagtacac gaaattccta ctaccagtgt
     9241 gaaaaccagc agtgaaattc gcattatctt tttattccaa tccatattct tttatttttc
     9301 ggtaaagggt acgctcggat atattaagat cctttgccgc gctttttcgt ttgccatgat
     9361 gcttttcaag ggctttacgt atcatttctt tctcgacttc gtccaacgaa agcgactctt
     9421 ccacatactc ttcggtatct tgtatgtcat cgtcatcggg acaattgggc ttgaccggat
     9481 gaatgatggc aggcactgag ggcgtagggg ctactaccgg agccggcgta taaaacgtac
     9541 cgacattgga ggttaccgct ccgcgctcgg acatgatttc gtgtacaagc tttttcagtt
     9601 cggtcacatc ttgtcgcatg tcaaaaagga cctgatataa gatttcacgt tcactttcga
     9661 agctcttccc tgtctttaca ccgaacaggg caggcaatcg ctgcgtactc tgagcaggca
     9721 gataagattg caagataggg gcattaatct cacggttagt ctcaattata gagatttgct
     9781 ccgtgatatt cttcaactga cgcacattac ccggccagga ataagacagc aaaacccgtt
     9841 tggcatcttc ggtcagctgt atggcgggca tacgatactt ctctgcaaag tcacttgcaa
     9901 acttacggaa cagtaacagc acatcttctc cacgctcccg caaaggaggg atctggatgg
     9961 gcaccgtatt gagacgatag tataaatcct cacggaaacg tccctctgca atggcctggg
    10021 tcaaattgac attggtagca gccacaatgc ggacatccgt tttctgtact ttggaggagc
    10081 ctacttttat aaactcccca ctctcgagta cacgaagcaa acgtgcctgc gtgggcaaag
    10141 gcaattctcc gacttcatcc agaaaaatag ttccgccgtc ggcttcacca aaatagccct
    10201 ttcgctcacc gatggctccc gtaaaagccc ctttttcatg accgaacagt tccgaatcga
    10261 tggttccttc aggaatagca ccacagttga cagcaatata ctgtccatgc tttcggcgac
    10321 tgtattggtg aatgatctga gggaaacttt ccttaccaac accactctct ccggttatta
    10381 gcacggacaa atcggtaggt gccacctgta tggcaacatc tatcgcacgc gtcaaagctt
    10441 cagtgttacc aataataccg aaccttagtt ttacctgttg tatttccgct tttgtcatat
    10501 tcgcactaaa ctcccttcct gattaaatat catcatctac tgtatcgagc ttcagtttat
    10561 cactgtcgtc tcgtttctcg taatactgtt tacgtaacgg attggcatgt gcttccttct
    10621 cacgttgacg gttacggaat acgtcgatcg ctacataaat agcctgacgg aatgaatctt
    10681 cgcaagcaac gccttttcct gcaatatcat aggctgtacc atgcgcggga gaagtgcgta
    10741 tcaccggcaa acccgccgtg tagttcacac cttcatccat ggccaatgcc ttgaaaggag
    10801 ccaatccctg atcgtgatac atggccagta ctccgtcaaa atgggtgaaa ttgcccgatc
    10861 ccataaatcc gtcagccgga taagggccat agcacaagat tcccttggca gccatttcct
    10921 gaatagcagg agaaatgatt tcctgttctt ccgtaccgag caatccgtcg tctccggcat
    10981 gcggattcag tgccaacact gcgatgcgcg gcgcaccaat cccgaaatcc tgtttcaacg
    11041 accggttgaa tatggcaagt ttctcctgaa tcagttcctt ggttattgaa gaggttatct
    11101 cacgaaccgg aatatgtcct gttaccaaag ctacccggaa atcctctttc atcaggatca
    11161 tcagtgattt tgaaccattc cccagacgtt gttcgatata ttccgtatgt ccgggaaaag
    11221 caaatccttc ggactgaatc gtatgcttat tgataggagc cgtcactatg acatcgatca
    11281 agccttccct gaactcctct atcgccttct caagtgctcc caaagctgct ttaccggctt
    11341 ccggatcggg ttttgagaac tctactttca cctcgtcatc cgtacagttg accacgctca
    11401 ggcgattgtg ggcagcttct gcagcggtat tgacaatact gaagttagta ggcaaatcga
    11461 gcgacttgcg gtgatatgca gccactttcg gagagccgta aatgaccggt gtacagagtt
    11521 ccaacatgac ggggtcggca aacgttttta aaatgacttc gtatcctacc ccgtttatgt
    11581 ctccctgagt gatgccaatt tttattttgt tatcttccat tttgttattt gttagttttc
    11641 tcctcctgct ctatgcccat cggaatctgt tcctgcgcct tctcggtagg aagttgcaaa
    11701 gtatacagag atgcttccaa tcggcgcatc aggtcacgtt tcattttatc gggtgagtaa
    11761 ataaatactt ctgtagtgat aatacggtgg ctggctttat ccagacgggt gtgcgaaaca
    11821 aacgggccac ccatgaaatc gccctttatg cgccacagtc cgcgtgcttc cattgtgtaa
    11881 tctccatgaa tatcaatcgg acgaacctct acggtagacg aatcagtcgc catgtacata
    11941 ccctctttgg cacccggaat attagccttc atcactgaat cgcgcttatg gataaagaac
    12001 tctttcgtaa aggtatcctt atctgtatac gggtaagagt agattacaaa gttctggtct
    12061 ccggtagcgg cattagtacc tgcccagaaa aagtcttctc ctgtcttcga actgctcagt
    12121 tcggccggaa gccagatatc actgttgaac atgctaccta ctttcgttga aatatagtca
    12181 ttatgatttt tctccaggaa agagatctga cggttcattt cggcacgggt aaagaagtct
    12241 ataatcggct gtttgttctc ttcgacaaac ttctcaaatg atgcctcgtc cggagcctga
    12301 atagtcaaaa tcatctgggg agatgcatat acatccttgg catacttgaa tttaggttgg
    12361 gtataaatgt cctgtatatc tacgataata atgttgcgca ccaacttcag gatggcatca
    12421 aaatctttgg gagaagtaga catgatcctg aacgaacgtt ccgattgcgg aagtccgggc
    12481 acatctgtat caagcacatt gtacaaagct ctaccggcag gacgctccca cacaggcttc
    12541 tcaaccacaa cgaggacttc ataagcacgt ccgctggaag ttggagtaaa cacactcttc
    12601 ttgccgcttt tacaagaaaa caacactact gctacaagag ccatactgag gtaaaacagg
    12661 tactttttca tatgcatcaa ttttaatgtt ttcacaaatc tacgaaatgg tcgtatactt
    12721 tcatccaatg tgctgataat ttatattaat tcttgttact ctcctcctgt ttagccgtcg
    12781 ataacatccc gcaagcggca aaaatatctt ctccccggga agctcgaatg gtagtgaaca
    12841 gtccatgtga ggtcaggtag tcacgaaatg acgtcatagc ctccataccg gcaccctcga
    12901 ggtctacccc aggaatggca tgaaaccgga ttaagttcac ccggcagtca agcccacgca
    12961 gcaatttcaa cagctcctta gcataaatca gcgaatcatt gacgccctta aaaacaatgt
    13021 attcaaacga aagtctgcgc tgtttactaa aatcatagtt ttttaacaga tcgaccattt
    13081 ctttaatcga gaaagccctt tcggccggca tcagctcaga acgttgtgaa ggaaaaggag
    13141 aatgcaggct gatagccaga tgacattcgc tttcttcaat aaagcgttga agtcctttcc
    13201 gcaatcctac agacgacaaa gtaatacgct tggggctcca tccgtatcca tacgaagcgg
    13261 tcaggatatg cagtgctttt aatacttcat ccaaattatc gagaggctcg cccatcccca
    13321 tcatcacgac attagtcaac ttatcccgct ctggcaatgc tgcgatttga ttcaagatct
    13381 gattggctgt cagacttgcg gtaaatcctt gtttacccgt catgcagaac ttacagttca
    13441 ttttacagcc tacctgagaa gacacgcaca atgtcgcccg atcctcgtcc ggaatataca
    13501 ccgcttcaac aaaatgattg tcactcacct gataaagata cttcaccgta ccatctacgg
    13561 aacgcatctc atcaacaggc gcggatatcc ccaaatcata ctctcccttg agcaactctc
    13621 tatgcttcaa cgacagattg gtcatttcat caatagaagt cactttttta tcgtataacc
    13681 aggaagcgat ctgtttggct gcaaaagcag gcatccccaa atctttggtg acagattgca
    13741 attcggtaag ggtcattcct aaaagcggat atttgggcat atttactaca aatatttatt
    13801 tattcatgca aatgtaagga ataaaagtcg attttaaaaa agagaaggga caaaagttaa
    13861 taggaagagg gaaagagata gcaaaaagaa aggccgttcc gtgcggaaca gcctttcgta
    13921 tattaaaacg acgttatcta aaaaaacaaa tccgttttta gaagaacagg tatcgtttat
    13981 cttttacatc gcctttcaga taaagatcgt tcataaaacg acttgccaga cgggcatgca
    14041 tgttttccaa tgtagcctct tctgattggg catcgaatgt ttcgttcagc ttatctttgg
    14101 catatacctg caacacaaac acaccgccat tacccttgat aggagcgctc agcttattga
    14161 tatccgaaac cgaagcgtat gcgcctacca gcggctcact actacgcaaa gcggctacat
    14221 aagcaggcgc tgcaaatgtt acgtgtttta cagaatcact tactgcattg gccatcgatg
    14281 tgtactgggc aattgtagtt gcattggcag ccttcatgtc ggccatgatc ttctcagctt
    14341 tcttatcacg aatgatttca gctctcaact gatcctgaac ctgggccaaa ggacgataac
    14401 cttcttcgat cacgctaacc agaccaacaa ccaacatgcg gtcgctttcg ccacattcat
    14461 ataagccgga aacttcaccc ggttttgcag caaaggccca tttcagtgct tctttagtcc
    14521 ctctgatacc accgattccg tgttctgagc tatacagatc atttctttcg agcaatttat
    14581 agcctgattc ttcagcattg gccgcaacct tgtctactgt cgggttagct gcaataaact
    14641 ggctgaattc attataagct ttattataag tttctttgct gaactcaact gcacgcttga
    14701 taacggcaac tttatattta tctttcacag ctttcttgtc agtcacctgc aaaatgatat
    14761 tgccttgtcc caatgctacg ttagagagtt cgtttactcc cagattgttg atagtgctga
    14821 taaatttcaa gttatcgcca tcaacctgtg cattttcgta gttagcagac gaaatccagt
    14881 tggattcacc tgtttgtccg tacttcttag ccagagctgt aaagtcggcc ccacccttaa
    14941 tagcagtata gatgctgtca gccaaagctt ttgttttagc agcgtcttct gtgtaaacct
    15001 gaatctgacg gaactgtaca gaatcggcag cagccacttt agacaacacc ttgaacgaat
    15061 tgatagtatt gtcgcctgca ttgtagtaag ggccatatac ttgtccaatc gaagctgaat
    15121 ccatgcgtgc aactacatct gacgggaaag ctttcttggt atagtacaaa tcaacatacg
    15181 gatattccga tccggtagaa cggatgaaag tagtataatc accattggca gtagccagtt
    15241 ggtttgtata atcagtcact tcctgctgga tagcagctct gtcttctgca ctggctgtca
    15301 cctgtacatc gatgtatttg atgttgcgtg tttcaacata ttgtttgaac tgttctttct
    15361 tcttgttata gagatctttc agttcagact ctttcactgt gatagtagag tctacaatag
    15421 aagaataagg aacagcagcc aacagaatat ccgactggtt tactcttgcg tcgaatgcat
    15481 cctgtgcttc aaccggatta gagaaaagag ctttagtcac cagtgcctgg tatttttccg
    15541 ccaaacggct ctggatcagt gtcttttcta caaatgacca aagtttgtgc attccttcat
    15601 agtattccac atattgagac ggcatcttgg tcttgtccat tttagagtag tcagccaaga
    15661 atttcttcaa catatcttta tcgaaagcgc ccgtttgagg attgcggaac ggagtctgct
    15721 gcagcaacgg attcacacct tcgttaatga ttgattgaat ttcagccttc gaaacagtaa
    15781 taccgagctt cttcgcttct ttttcaatca gtttattgtt cacatagcta cgccatactt
    15841 cgtctttcac ctgattggtc tgttcatcat tcaatgaact cattccgctt gagaacttga
    15901 taacctcggt atattcttct accatgttct ggtagtcctg agcagaaaga gtttctccat
    15961 tgacttcgcc tacatcatgc gattggtgtg gctggagaac tttccaggca tcgcccgcaa
    16021 tgaaagcaaa caaagccaaa ccaataacga tc
//
