LOCUS       gnlProkkaDEDALPJK_75   13171 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|DEDALPJK_75.
ACCESSION   gnlProkkaDEDALPJK_75
VERSION     gnlProkkaDEDALPJK_75
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-16 23:50:46
            Original ID  :: gnl|Prokka|DEDALPJK_75
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 83496
            Orig. end    :: 96667
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13171
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[5000:12024]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..12024
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..13171
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13171
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             512..1525
                     /locus_tag="ctg57_63"
                     /transl_table=11
                     /translation="MMKRHNILTVLAVLLLTFAACDKNSAPGFSFTTDSILTLTFDKEL
                     DAAFVGVGTQNYNPVGMRRSGDTLFIANRAEGSDGVWVVRASTGELLYSLTGWTYNGKN
                     EKFDNQVMDVAVSSDYIFVVNRSSRIDLFRRNDYSYVTTIGRTGWQSSSLLQCEAAEVA
                     GDKLFIRDKQKIKVVQISDCTPENRFKVPVFAQNTDSTSSNNGFNLESVARHEGLIYVS
                     DYETSRILVIDPATVAVKGEPVRFLRSYRMPNKPLSMGFFQNEMYVVCANNRIVRVDLR
                     TGKELGSYSSFAGGVGLGTPGRLFFHNDTFYLAGRNANAPRLIQGKVMFVEISELD"
     CDS             1645..2649
                     /locus_tag="ctg57_64"
                     /transl_table=11
                     /translation="MNLKFLYLLLLISALCISCSKDEEPSDKGSTSPQEPVYTTFTDAG
                     EVVVPGVLPANFTPRSVRVKGDTLFVANTNAADRSVLLLNLTTGELIGRIDSWVRKGVK
                     ETFNAEIGDMAVSDRYIFVGMYNSRINIFDRRTLQFVNAIGRSDGKWGDDIYSMTHCYG
                     LRECGERLMVRDKNTIRGYWIYEAVTEPAFRVPWIGKVKVSEGVGYDYQARIHGMAEYD
                     GRMYLTDWYNKSVQVFTPSKMEIVFGEETHITSDAVFKYDDIQPLGLLAYGGELLMSVQ
                     KSGKIQRYDPETGDLLGVLAEFPGKEIGRMEIARGMLYYIDLKAGKLMKAKGE"
     CDS             3970..4488
                     /locus_tag="ctg57_65"
                     /transl_table=11
                     /translation="MSEQQEYWFAARTKKDQEFSVRNALEKLGIEYFLPTQFVIRQLKY
                     RRRRVEVPVIKNLIFVRTTKDRAWSITKDDHVPLYYMKDLYTHTLLIVPNKQMEDFKFV
                     MDLAPENVTFDDLPLTIGTKVQVVKGEFCGIEGELSSLANRTYVVIRIHGVLSASVKVP
                     KSYLRILSA"
     CDS             4508..4981
                     /locus_tag="ctg57_66"
                     /transl_table=11
                     /translation="MNQVQNLQHIARELLYLGMDGSPIYTDHFRQLNTEVFRLSEALFS
                     MKGTTSEEEAAICLSLLMGYNATIYNDGDKESKIQSILDRSFAVLDHLPASLLKCQLLT
                     YCYGEVFEEDLAQEAHQIMDSWKNRALSEEELEVMETLQTMEDNRYPCSEVED"
     CDS             5001..5888
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 271; E-value:
                     1.9e-82)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg57_67"
                     /sec_met_domain="NTP_transf_3 (E-value: 5.8e-13, bitscore:
                     41.7, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKGIVLAGGSGTRLYPITKGISKQLLPIFDKPMIYYPISVLMLAG
                     IRKILIISTPYDLPGFQRLLGDGSDFGVHFLYAEQPSPDGLAQAFIIGEEFIGDDSVCL
                     VLGDNIFYGQSFTRMLQEAVRTVESENKATIFGYWVKDPERYGVAEFDNDGNVLSIEEK
                     PDTPKSNYAVVGLYFYPNRVVKVAKNITPSFRGELEITTVNQHFLLDQKLKVQLLGRGF
                     AWLDTGTHDSLSEASTFIEVIEKRQGLKIACLEGIALRQGWISSEKMKVLAQPMLKNQY
                     GQYLLKVIDELSVK"
     CDS             5899..6453
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) dTDP_sugar_isom"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg57_68"
                     /sec_met_domain="dTDP_sugar_isom (E-value: 3.3e-72,
                     bitscore: 234.0, seeds: 19, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEILKTTIEGLIIIEPKLFWDGRGYFFESFNQKEFEEKVCKIVFV
                     QDNESKSHYGVIRGLHFQKPPFAQSKLVRVIKGAVLDVAVDIRKGSPTFGKYFSVELTE
                     DNHRQFFIPRGFAHGFSVLSEEVIFQYKCDNFYHPEAEGAIVWNDTELKIDWKIPIEKI
                     TLSEKDKAYPNFMDQDFHFNY"
     CDS             6460..7743
                     /locus_tag="ctg57_69"
                     /transl_table=11
                     /translation="MIRSFLSRSPLYVLALYASVLIFLVYTCAYAYRKPFTAAIYEGEI
                     LWGFDVKILYVLSEIIGYALSKFIGVRILPSMKAGHRIYYIIGLLTFSEVALLGFALLP
                     VPLKVCSIFLSGLPLGMIWGVIFSYIEGRRISEILNVGLSVALIVSSGLVKTLGQFVMD
                     NLHVSEYWMPFTTGLLVYPVMLLCSWLLNQIPAPNEQDIIQRTKRAPMDGKDRRKFLRQ
                     FFWGICMLVVFYGALTVFRELRDSFAADIWKELHIEGAMIFTQTEVPIAVFVLVLMFLI
                     VFVRNNRLALNIIYCIAVTGGSLMVFSTLLYVYGFLSPIWWMILSGLGLYMGYIPFTYL
                     IERLIASLRVVSTAVFIIYLADSFGYLGTTGVFMVKNFVSADISWTVMLMRTALFSGFV
                     SVLSIFAIYCYFKQQLNSLILIPSEIHD"
     CDS             7736..8455
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 56.5; E-value:
                     3.8e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg57_70"
                     /sec_met_domain="NTP_transf_3 (E-value: 4.6e-15, bitscore:
                     48.6, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKTAMIMAAGLGTRFGHYTELVPKGFVEVGGKPMIIRSIETLLS
                     CGIERIILGTGYKKEAYEALQADFPQIETCFSPRYADTNSMYTLYNTRDVIGDDSFLLL
                     ESDLVFERKAILSLLDDEFPDVMLVSSLTKFQDQYYVEYDRNHILTSCSVDKDALEAKG
                     ELVGIHKLSNTFYRRMCADYATILESQPKLGYEYELLRMSRSVSPVRVLRVEGLKWYEI
                     DDEADLSYAEEHIIRYC"
     CDS             8475..9776
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 214.1;
                     E-value: 3.9e-65)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg57_71"
                     /sec_met_domain="CTP_transf_like (E-value: 1.9e-12,
                     bitscore: 39.9, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 6.9e-122, bitscore:
                     398.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 3.5e-64, bitscore:
                     208.8, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKKIYVGMTADIMHPGLIHIIHEATKYGDVIVGLLTDKAIAEHK
                     RLPYLTYDQRKEVVENIKGVCEVVPQEDWSYVPNLEKLKPDYIIHGDDWKTGPLREVRE
                     QVFEVMNAQGGKVIEIPYTRGINSSSLDKDIKAIGTTPDVRLKSLRRLIQAKPVVRILE
                     AHDGLCGLIIENLEVQKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAVIIEDKVGLKKNSLFGTDAIQTQDS
                     IEGFCDKIRAGKNAQVTGDFMIIARIESLIAGKPMSDALERAYAYVQAGADGIMIHSKD
                     KSGEDIREFCRTFRKEYAHVPIVVVPTTYDHVHESELHEWGANVVIYANHLLRAAYPAM
                     MNVARTILENERAEEVRPLCMPIKEILELIPGTK"
     CDS             9788..10924
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 70.6;
                     E-value: 1.9e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg57_72"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.1e-21, bitscore:
                     69.4, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3.7e-20, bitscore:
                     64.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVSVEKIYDTFLHHGVDFFTGVPDSLLKNICAYITDHAPRGKHII
                     AANEGSAVGIACGYYMASGNVPLVYMQNSGLGNTVNPLLSLADEKVYSLPLLLLVGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMKIPFIILDTDEDEALAQIHDAVVSAKSRSIPHAIV
                     IRKDTFGKYKLRQEALNDYPLSREEALMQVVDHLGDNDIVVSTTGKLSRELFEYRESKG
                     QGHARDFLTVGSMGHSSSIALGIALEKPDRRVYCLDGDGAFIMHMGAVSNIGDLSPKNY
                     RHVLFNNGAHESVGGQPTLGFRLDIASIAKGCGYAHVLTASDKEGLSCALEKLSGLSGP
                     VLLEIKVRIDSRDDLGRPTTTPVENKEHFMAFLKDTHS"
     CDS             10921..12024
                     /NRPS_PKS="Domain: Aminotran_5 (30-298). E-value: 6.2e-34.
                     Score: 109.3. Matches aSDomain:
                     nrpspksdomains_ctg57_73_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 80.5; E-value:
                     1.9e-24)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg57_73"
                     /sec_met_domain="Aminotran_5 (E-value: 5.8e-31, bitscore:
                     99.9, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIERKILLNPGPATTTDTVKLAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGDLSKHTAVLFCGSGTINIDICLNSLLPADKKVLVVNNGAYSTRAVEVCEYY
                     GLPHIDLKFSVYELPDLSVIEKTLSDNPDIALVYTTHHETGTGILNPIREIGKIAHSHG
                     AVFVVDTTSSLGMIPFDIGKDNVDFCMASAQKGLQAMTGLSFIIGDESLIRASRDYPKR
                     SYYCNLYLQYDYFEKTGEMHFTPPVQTVYAARQALDEYFAVGEEAKFARHKRVFEAIHK
                     GLQELGLQYAIKREWQSGLVVSVLYPDDPLWDFDKVHDYCYERGFTIYPGKISTTNTFR
                     LCALGEIDVEDIERFFEVMREAVKFVK"
     aSDomain        11011..11814
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg57_73_Aminotran_5.1"
                     /evalue="6.20E-34"
                     /label="ctg57_73_Aminotran_5.1"
                     /locus_tag="ctg57_73"
                     /protein_end="298"
                     /protein_start="30"
                     /score="109.3"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGDLSKHTAVLFCGSGTINIDICL
                     NSLLPADKKVLVVNNGAYSTRAVEVCEYYGLPHIDLKFSVYELPDLSVIEKTLSDNPDI
                     ALVYTTHHETGTGILNPIREIGKIAHSHGAVFVVDTTSSLGMIPFDIGKDNVDFCMASA
                     QKGLQAMTGLSFIIGDESLIRASRDYPKRSYYCNLYLQYDYFEKTGEMHFTPPVQTVYA
                     ARQALDEYFAVGEEAKFARHKRVFEAIHKGLQELGLQYAIKREWQS"
     CDS             12035..12847
                     /locus_tag="ctg57_74"
                     /transl_table=11
                     /translation="MEDLNRYNKEGSDLRKLQYRMLELLEVLDKICKKHNLPYWLEGGT
                     LLGAVRHGGFIPWDDDLDVQMLRSDYKKLLKILPKELPGNIALQTFKTDKGYYRYVAKL
                     RDLNSKLISTSVDYKDCKFQGVFIDIIPMEFIKSKFLNKVSIYIRWKIVALKVKIPNDK
                     LGLKILLFNIIYFFENLMHFSFRLVDLFIRKNRELSYSYGIDFYEYSCPIEYIFPLSSI
                     TFENKVFWAPHDVDGMLRRNYGNNYMEIPPEDQREIQAHSLGVIFNEK"
     CDS             12849..13169
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg57_75"
                     /sec_met_domain="Polysacc_synt (E-value: 9.2e-22, bitscore:
                     70.0, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLHSIFKNSLYKGALNFFNLVLPLLVTPYLYRILSPETIGQVEYS
                     TSIFGYFSLFGVLGIYNYGLREVSKNRDRQEKVKSIYANLFLIGCLSNFIVACIYLLFI
                     RLS"
ORIGIN
        1 tgacagcaaa tgcagcccgc tactatgcca catcggtggt gaatatggct gtcatgttca
       61 gttccgaaat ttttcgtgat tcattgatga actacaaagg tagcattcac aatgatgcag
      121 gaaaggagat cgaccgtgaa gggctactga attcaattct caataaacaa agtcttgtgt
      181 tcggagtggt taccggttcc ggtatcgccg ggctcggtgg aggaaatgct ttgggattgc
      241 gtgaagaata tctggccgga ttcttctacc agaaccgggt ggcaatcgat tgcaactggg
      301 tgcttcatgt ctggattcac gagctagggc actgtctggg ctatggtcat tctagcagcc
      361 tgtgttacgg gtcggtgccc gatgaaatag taccgaaagt gtatcgctac atgatgaagc
      421 accgcatgct gccttatatc atcaatccct ttaagagtta caatgattat aatcccggca
      481 tcaatgatgc cgacaatccc gacatagagc tatgatgaag agacataaca tactgacggt
      541 actggcagtc ctgctgctca cctttgccgc atgcgataaa aatagtgccc ccggattcag
      601 tttcacgact gactccatcc ttacattgac tttcgataaa gagctggatg ccgcctttgt
      661 cggagtgggg acccaaaatt acaatccggt gggaatgcgg cgttcgggcg atactctttt
      721 cattgccaac cgtgccgaag gttctgacgg tgtgtgggtg gtacgcgctt cgaccgggga
      781 gttgctttat tcgctgaccg gctggaccta caacgggaaa aacgagaagt tcgacaatca
      841 ggtgatggat gtggcggtca gcagcgatta catctttgtg gtgaaccgtt cgtcccggat
      901 cgacctgttc cgacggaacg attattcgta tgtgaccacc atcgggcgta ccggatggca
      961 gtcgagttct ctgttgcaat gcgaagcggc cgaagtggct ggtgataaat tgttcatccg
     1021 tgacaaacag aagattaaag tggtgcagat ttcagattgt acgcctgaaa atcgttttaa
     1081 ggttcctgtc tttgctcaga atacggacag tacgtcttct aataacggtt ttaatcttga
     1141 gtccgttgcg cggcatgaag gcttgatcta tgtgtccgac tacgaaacct cacgcatcct
     1201 ggtgatcgat cccgccaccg tggcggtcaa gggagagccg gtacgctttt tgcgctctta
     1261 ccgcatgccg aacaaaccgc tcagtatggg attctttcag aacgaaatgt atgttgtctg
     1321 cgcaaataac cgcatcgtga gagtagacct ccgtaccggg aaagagctcg gctcttattc
     1381 atcctttgcc ggaggagtgg ggctgggaac tcccggacgc ctctttttcc ataatgatac
     1441 attctatctt gcagggcgca atgccaatgc tccccggctg atacagggga aagttatgtt
     1501 tgttgaaata tccgagctgg actaaaaaaa tgaataatta cgattcgctg cagattatgc
     1561 aggtttgtac actcctctat atccggatga cggtttaaga gaagaaaact ttctgtgtcg
     1621 tctgtggtga gaaaacaatc aagcatgaat ttgaaatttt tatatctgtt attattgata
     1681 tctgccctgt gtatatcctg ttccaaggac gaagaacctt cggataaggg cagtacttct
     1741 ccccaagagc cggtttacac cacctttaca gatgccggcg aagtggttgt tcccggagtg
     1801 cttccggcca atttcactcc ccggtccgta cgggtcaagg gggacacttt gtttgttgcc
     1861 aataccaatg ccgccgaccg ttccgtgctg ttgctgaacc tgacgacagg cgaactgatc
     1921 ggacgtatcg attcatgggt acggaaaggt gtcaaagaga cctttaatgc cgagataggc
     1981 gacatggctg tttctgaccg ttatatcttt gtgggtatgt acaactcccg tattaatatt
     2041 tttgaccgtc gcacccttca gtttgtcaat gccatcgggc gttcagacgg aaagtgggga
     2101 gacgatattt atagcatgac ccattgctac ggacttcgtg agtgtggcga gagactgatg
     2161 gtgcgtgata aaaataccat tcgcggctat tggatttacg aagccgttac cgaacctgcg
     2221 ttccgggttc cctggatcgg aaaggtgaaa gtgtccgaag gagtcggata tgactatcag
     2281 gcccgtatcc atggtatggc agagtatgac gggcgtatgt atctgaccga ctggtacaac
     2341 aagagtgtgc aagtgttcac tccgtcgaaa atggagatcg tgttcggtga agagacacat
     2401 atcacttccg atgccgtgtt taagtacgat gatattcaac cgctcggact gcttgcctac
     2461 ggaggcgaat tactgatgtc ggtacaaaag agtgggaaaa tacagcgtta tgatccggag
     2521 acaggagacc tgctcggagt gctggccgag tttccgggta aggagatcgg gcgcatggag
     2581 atagcccggg gaatgcttta ctacattgac ctcaaagccg ggaaactgat gaaggcaaaa
     2641 ggagaataaa gaacggcgag agtgtgtcat gactcaccac agagcaatct gtggtgaata
     2701 cgagtttcga cacaccctcg ttctttcatc tgcatgtcct atccgaagca gaagtaatac
     2761 tcagaaccgt cgctgacata aaaagaatct gctttctttt cgataaaaag aactgttctc
     2821 ttttgccaac catccgacag caagcattac atcgtctata ttcaggcagg tcaagctgca
     2881 aagttctttc acagagactt ttcttgcatg tataagtatt cgtcatactt ttctggagtt
     2941 ttctccgatt ttcacttttt ccatattact atttatagcc tatttaaatc aaatttggtg
     3001 gtaaattctt tatctccaag ttgataattg tcctttttgc ttgctttaat aagaaaaaac
     3061 agacaccggc tgaataagat aactcaagtt ttggaagtga atttatgccg tctgaaccgg
     3121 tatcttcatc cttatacttt tcttcaatta acattgttaa cgccttttac aggttgtcag
     3181 gttcttgtgc gcaaataaca agtcttttgc atttaaagaa cttcttattt atatccaaag
     3241 aacaagcttt aactttgtgt taaaacaaag cttttgaaga cagaaatctt actttttaaa
     3301 gatgttgatt ttcagatagt ttagtctaag attcgcttct tcacctcacg aatggacact
     3361 tcgggcgaaa gccgggatac ttgctttttt gtcaactata aacgagggct tgcacttccg
     3421 aaaactgaat tagattccat gagtaaaaga aaacttacca ccaaacttga cgaagaacct
     3481 gttttctaaa gtaggtgtcg tctcgcgcgt aaggagaaat ttttttgtgt aaatgatagg
     3541 aggctagggt acttacctat tggactacaa acagatacgt aatataaagt agatggaaga
     3601 aaaggggagg ggtgtttcaa aaaacgttcg tttataaaca caaaggtaag gcacattttt
     3661 ataacaacaa aatattttta taaataaatt gagtttttct ttctttatct attttagtat
     3721 actgattata agagtattat atacatgaaa tagaatcttt atatatgtgt tttttctata
     3781 agaacatgat ttttagaaaa ggtcgaaaaa aggtgttcca aaagacgaac gttttttgaa
     3841 acaatttcat tcgttttacc actaaaaata gtttcggaaa ttcttacggt ttgaatggga
     3901 aaagatgtct cgtccaaacc gcgtagcgca cccgaaagta acctctcgac ttttaatatc
     3961 cactaataaa tgtctgaaca acaggagtat tggtttgccg ctcggacaaa gaaggatcag
     4021 gagttttctg ttcgcaatgc tttagaaaag cttggaatag aatactttct tccaacacaa
     4081 tttgtcatcc gtcaactgaa atatcgtcgt cgtagggtag aagttcctgt tatcaagaat
     4141 cttatttttg tccggaccac gaaagaccgt gcctggtcta tcacgaagga tgatcatgtt
     4201 cctctttatt atatgaagga tctctatacc catactttgt tgatcgttcc caacaaacag
     4261 atggaagatt tcaagtttgt gatggattta gctccggaaa atgtaacttt tgatgatctt
     4321 ccccttacca ttggtacaaa agtgcaggtc gtcaaaggag aattttgtgg cattgagggc
     4381 gaattgtcca gccttgccaa ccgtacttac gtagtgattc gtatccacgg agttctttct
     4441 gccagcgtca aagtacctaa aagttacctt cgtattcttt cagcgtaatt cgtaatttca
     4501 aaattatatg aatcaagtcc aaaatctgca acacattgcc cgtgagttgc tttatttggg
     4561 tatggatggt tctcccatct ataccgatca tttccgtcaa ctgaacaccg aagtttttcg
     4621 cttgtccgaa gcccttttct ctatgaaagg taccacatcc gaggaagaag cagcgatttg
     4681 tctgtccctg ttaatgggct ataatgctac catttacaat gatggcgaca aagaatctaa
     4741 gatacaaagc attttagatc gctcttttgc cgtattggac catcttcctg cttctctatt
     4801 gaaatgccaa ttgctgactt attgctatgg cgaggtattc gaggaggatt tagcacaaga
     4861 agcacatcaa ataatggata gctggaaaaa tagggcactt tcagaagaag aattggaagt
     4921 gatggagaca ttgcagacaa tggaagataa tcggtatccg tgtagtgagg tagaagattg
     4981 ataaaataac atataaaaaa atgaaaggta ttgttttggc gggtggttca ggaacacgtt
     5041 tatatcctat tactaaagga ataagcaagc agttgcttcc tatttttgat aaaccgatga
     5101 tttattatcc tatttcagtt cttatgttag caggaattcg gaaaatatta attatttcta
     5161 ctccgtatga tttgccagga tttcaacgtt tattaggtga cggctctgac tttggggttc
     5221 atttccttta tgctgagcaa ccttctcctg atggcttggc gcaggctttt attattggtg
     5281 aagaatttat aggagatgac tcagtatgtt tggttttagg agataatatt ttttatgggc
     5341 agagttttac tcgtatgtta caagaggcag tccgtacagt agagtcagaa aataaagcaa
     5401 ccattttcgg ttattgggtg aaggatcccg aacgttacgg tgtagcagag tttgacaatg
     5461 atggcaatgt acttagtata gaagaaaaac ctgatacacc taaatctaat tatgccgttg
     5521 taggacttta tttttatcca aatagagttg ttaaagtggc aaaaaatata actccttctt
     5581 tccgaggaga attagaaata acaactgtta atcaacattt tcttttggat caaaaactaa
     5641 aggttcaatt attaggccgt ggttttgctt ggttagatac gggtacgcac gactctttat
     5701 ctgaagcaag tacctttatt gaagtgatcg agaaacgtca aggtttaaaa atcgcttgtt
     5761 tggaagggat tgcactgagg caaggatgga tttcttcgga gaagatgaaa gtattagcac
     5821 agccaatgtt gaaaaatcaa tatggccaat atttattgaa agttattgat gaattatcag
     5881 taaagtaaat gtctttttat ggaaatattg aaaacgacaa tagaaggact tattattatt
     5941 gagcctaaac ttttttggga cggtcggggc tatttctttg aatcttttaa tcaaaaagaa
     6001 tttgaagaga aagtatgtaa gattgtgttt gttcaagata acgaatccaa gtctcactat
     6061 ggcgttatac gcggtcttca tttccagaaa cctccttttg ctcagagtaa attagttaga
     6121 gttattaaag gggctgttct tgatgttgca gttgatattc gtaaaggttc accgacattt
     6181 gggaaatatt tttcagtaga actaacagaa gataatcatc gtcagttttt tattccaaga
     6241 ggattcgctc atggctttag tgtattaagt gaagaggtca tttttcaata taaatgtgat
     6301 aatttttatc atccggaagc ggaaggggcg attgtttgga atgatacaga attgaagatt
     6361 gattggaaga taccaattga aaaaattaca ttgagcgaaa aggataaagc atatcctaat
     6421 ttcatggatc aagactttca ttttaattac tagaagataa tgattcgttc ctttctttcc
     6481 cgttctcccc tttacgtttt ggctctctat gccagcgttt tgatttttct ggtttatact
     6541 tgtgcctatg cctaccgtaa gccatttacc gcagccattt atgaaggtga gattctttgg
     6601 ggattcgatg tcaaaatcct gtatgtcctt tctgagatta tcggctacgc cctttccaag
     6661 ttcatcggtg ttcgtattct gccttcgatg aaagcgggtc accgcatcta ttatataata
     6721 gggctgctta ctttttccga agttgctttg ttgggttttg cacttcttcc ggttcctttg
     6781 aaggtgtgtt ctatttttct gagcggtctt cccctgggta tgatctgggg tgtcattttt
     6841 agctatatcg aaggacgtcg tatcagtgaa atattgaatg tcgggctgag cgttgctttg
     6901 atagtctctt ccggtttggt gaaaaccttg ggacaattcg tgatggataa tttgcatgtg
     6961 tcggaatatt ggatgccttt taccaccggt ttgttggtat accctgttat gttgctttgc
     7021 agctggcttc tcaatcagat tccggctccc aatgagcaag atatcataca gcgtaccaaa
     7081 cgtgctccga tggatggtaa agacaggcgt aaatttttga ggcaattctt ttggggaatc
     7141 tgcatgctgg ttgtttttta cggtgccctg accgtgttcc gtgagcttcg tgactctttc
     7201 gctgccgata tttggaagga gctccatatt gagggtgcaa tgatctttac tcagacagag
     7261 gttcccattg ccgtttttgt ccttgtactg atgttcctga ttgtgtttgt ccgtaataac
     7321 cgtttggctc ttaatatcat ttattgcatc gccgtcacag gcggttcctt aatggttttt
     7381 tccacattgc tttatgtgta cggttttctt tctcctattt ggtggatgat tctttccggt
     7441 cttggtctgt atatggggta tattcctttc acttacctga tagaacgtct gattgcttcc
     7501 cttagggtgg ttagtacggc tgtttttatt atttatttgg ccgattcttt cggctatctg
     7561 ggcactacgg gtgtgtttat ggtcaagaac ttcgtttctg ctgacatttc ctggactgtc
     7621 atgctgatgc gtactgccct tttttcagga tttgtttctg tcctgtcgat ttttgcgatt
     7681 tactgttatt tcaagcaaca attgaattca cttatattaa ttccctctga aattcatgat
     7741 taaaacagca atgatcatgg ctgccggtct tggtacccgc ttcgggcatt ataccgagct
     7801 tgtgcccaaa ggttttgtgg aggttggtgg aaaacctatg attatccgct ctatcgaaac
     7861 ccttctttcc tgcggtatcg aacgtatcat cctcggtacg ggttataaaa aagaggctta
     7921 tgaagccctt caggcggatt tcccccagat agagacctgt ttcagtcccc gttatgccga
     7981 tactaacagt atgtacactc tgtacaatac gcgtgacgtg ataggcgatg acagtttcct
     8041 gctgcttgaa tcggaccttg tttttgaacg caaggccatc ctctcgctgc tggatgacga
     8101 attcccggat gtgatgcttg tctcttctct gaccaagttc caggatcagt attatgtgga
     8161 atatgaccgc aatcacatcc ttacttcctg ttcggtagac aaggacgccc ttgaggcaaa
     8221 aggcgagctg gtcggtatcc ataaactttc caatactttc taccgccgga tgtgcgccga
     8281 ttatgcgacc atcctggagt cccagcctaa actgggttac gagtacgaac tgctccgcat
     8341 gtcccgttcc gtttcccctg tccgtgtgct cagggtggag ggtcttaaat ggtatgaaat
     8401 cgatgatgaa gccgaccttt cgtatgctga ggagcacatc atccgctatt gttaaaaaca
     8461 aatcttttcc atatatgaac aagaaaatct atgtcggtat gaccgcggat atcatgcatc
     8521 cggggttgat ccatattatt catgaagcta ctaaatacgg tgatgtcatc gtcggtctgc
     8581 tgacggacaa ggccatcgcc gaacacaaac gcctccctta ccttacctat gatcagcgta
     8641 aggaggttgt tgagaatatc aaaggggttt gcgaagttgt tccccaggag gattggagct
     8701 atgttccgaa tctggaaaaa ctcaagcctg actatatcat ccacggcgac gactggaaaa
     8761 cgggcccgtt gcgcgaggtg cgcgaacagg tttttgaggt gatgaacgcc caggggggca
     8821 aggtaatcga gatcccttat acccggggca tcaactcctc ctcgctcgac aaggatatca
     8881 aggcgatcgg gactacccct gacgtacgtc ttaagtccct ccgccgcctg atccaggcca
     8941 agcctgtggt ccgtatcctg gaggctcacg acgggctttg cggtctgatt attgagaatc
     9001 ttgaagtcca gaagggtgat aagcgcgagg tctttgacgg catgtggtcc agcagcctga
     9061 ccgactccac gagtaagggt aaaccggata ttgaagcggt cgaccttacc acccgtttac
     9121 aggacctgaa caatatcctt gaatgcacca ccaagcctat tatttttgat ggagacacgg
     9181 gtggcaagat cgaacacttt gtctttactg tgcgcacttt ggaacgtcac ggcatttctg
     9241 cggtaatcat tgaagataaa gttggtctga agaagaattc cctttttggt actgacgcta
     9301 tccagactca ggatagtatc gagggtttct gcgataagat cagagcaggg aagaatgccc
     9361 aggtcaccgg tgactttatg atcattgcgc gtatcgaaag ccttattgcc ggcaaaccca
     9421 tgagtgacgc cctcgaacgt gcttatgcct atgtacaggc gggggcggac ggcatcatga
     9481 tccacagcaa ggataagtcg ggtgaggata tccgtgagtt ctgccggact ttccgcaaag
     9541 aatacgccca tgttcccatt gtcgttgttc cgacgactta tgaccatgtg cacgaatccg
     9601 aacttcacga atggggtgcc aacgtagtca tttacgccaa ccaccttctc cgtgccgctt
     9661 atccggccat gatgaacgtg gccaggacca tccttgaaaa cgagcgcgcc gaggaggtcc
     9721 gtccgctttg tatgcctatc aaggaaattc tggaattgat tccgggcact aaataaatca
     9781 gacggttatg gtaagtgtag aaaagatata cgatacgttc cttcatcacg gtgttgactt
     9841 ctttacgggt gttcccgatt cccttttgaa gaatatttgc gcctatatca cggatcatgc
     9901 tccgcgtggt aagcatatca tcgccgccaa tgaaggttcc gcggtgggca ttgcctgcgg
     9961 ttattatatg gcttctggca acgttccttt ggtttatatg cagaactccg gtctgggaaa
    10021 tacggtgaat cccctcttgt cccttgcgga cgagaaagtg tacagccttc ctcttctttt
    10081 gctggtcggt tggcgcggtg agcccggcac gaaagacgaa ccccagcata agaagcaggg
    10141 cgaggttacc cttgatcttc tgaaagccat gaaaattcct tttataattc tggatacgga
    10201 tgaagacgag gccctggcgc agatccatga cgcggttgtc tcggcgaaga gccggtcgat
    10261 tccccatgcg attgtcatcc gtaaagatac gtttggaaaa tataaattgc gtcaggaagc
    10321 cttgaatgac tatcctctgt cccgcgagga ggcgctaatg caggttgtcg accacctcgg
    10381 ggacaatgac attgtggttt ccaccacggg caagctctcc cgtgagcttt tcgagtaccg
    10441 tgaatcgaaa gggcaggggc acgcaaggga tttcctaact gtgggttcca tgggtcacag
    10501 ttcttccatt gccctgggga ttgcccttga gaagcctgac cgccgtgtct actgtcttga
    10561 cggtgacggt gcctttatca tgcacatggg tgctgtcagc aatatcggcg atctttctcc
    10621 caagaattac aggcacgtcc ttttcaataa cggtgcccat gaatctgtcg gcggtcaacc
    10681 cacgctcggt ttccgtctgg atatcgcctc gatagcgaaa ggttgcggtt atgcgcatgt
    10741 actgactgcc tccgacaagg aagggctttc gtgtgcgctt gagaagctgt ccggcctgtc
    10801 cggcccggtt cttcttgaaa ttaaggtccg gatcgattca cgtgatgatc tgggtcgccc
    10861 tacgactact ccggtagaga ataaagagca ttttatggca tttttaaaag atacgcattc
    10921 atgaatatcg aaagaaagat ccttttgaat ccgggtcccg ccaccacgac ggatacggtg
    10981 aagctggcgc aggttgttcc cgatatctgt ccgcgtgaga aagagtttgc gggtatgatg
    11041 aaacagttac gtgacgacct ggtccgcgtt gcgcatggag acctctccaa acatacggcc
    11101 gtcctgtttt gcggctcggg gacgatcaat atcgatatct gcctgaactc tcttcttcct
    11161 gcggataaga aagttctggt tgtcaataac ggtgcctaca gcacccgtgc ggtggaagtc
    11221 tgcgaatatt acggtcttcc ccatatcgat ttgaagtttt ccgtttacga acttcccgac
    11281 ctgtcggtaa tcgaaaagac gctttccgac aatccggaca tcgctttggt ctataccacg
    11341 caccatgaaa cgggtacggg tatcttgaac cccatccgtg agatcggaaa aatagcccat
    11401 tcgcacggtg ccgtttttgt tgtcgacacc acttcctccc tgggtatgat tccttttgat
    11461 atcgggaagg ataatgttga cttttgtatg gcttcggctc agaaaggcct tcaggccatg
    11521 acggggcttt cctttatcat aggtgatgaa tccctgatac gtgcttcaag ggattatccg
    11581 aaacgttcct actattgtaa cctctattta caatacgatt actttgagaa gacgggcgag
    11641 atgcatttta ctcctcctgt tcaaaccgtt tacgctgccc gtcaggctct tgatgaatat
    11701 tttgcagtag gtgaagaggc taaattcgcc cgtcacaaga gggtctttga agccatccat
    11761 aaaggtttgc aagagcttgg tcttcagtat gcgatcaaac gtgaatggca gtcgggtctt
    11821 gttgtttctg tattgtatcc tgatgatccc ctctgggatt ttgataaggt tcatgattac
    11881 tgctatgaac gtggctttac gatctacccg ggtaagattt ccacaacgaa tacattccgg
    11941 ctttgtgcgt tgggagagat tgatgtggag gatattgaga ggttctttga ggtgatgaga
    12001 gaagctgtga aatttgttaa ataaatttgt attaatggaa gacttaaata gatataataa
    12061 agagggttca gatttaagaa agcttcaata ccgtatgctg gaattattgg aagttttaga
    12121 taagatatgt aaaaagcata accttccata ttggctagag ggagggacct tattaggtgc
    12181 agtaaggcat ggaggattta ttccttggga cgatgattta gatgttcaaa tgcttcgttc
    12241 tgattataaa aaattattaa aaatactgcc caaagaatta cctggtaaca ttgctcttca
    12301 gacatttaaa acggataaag gatattatcg ttatgtagct aaactaagag atttaaattc
    12361 taaattgatt tctacatcgg tagattataa ggattgtaaa tttcaaggag tatttatcga
    12421 tattattcca atggaattta ttaagagtaa gtttttaaat aaagtttcta tatatatacg
    12481 atggaagatt gttgcattga aagtgaaaat acctaatgat aaattgggat tgaaaattct
    12541 tttatttaat attatatatt tctttgaaaa tttgatgcat ttttctttta gactagtaga
    12601 tttatttatt cgaaaaaatc gagaacttag ctattcttat ggtattgatt tttatgaata
    12661 tagttgtcct attgagtata tttttccatt aagttctata acgtttgaga ataaagtgtt
    12721 ctgggctcct catgatgttg atggtatgtt gagaaggaat tatgggaata attatatgga
    12781 aatacctcct gaagatcaga gagagataca ggcgcattct ttaggagtca tttttaacga
    12841 aaaataaagt gcttcattct atatttaaaa attcactgta taaaggggct ttgaattttt
    12901 ttaatttagt acttcccctg ttggttacgc cttatttata tcgtatacta tctccggaga
    12961 caattgggca agtagaatat tctacttcta tttttggata ttttagtttg tttggagtac
    13021 ttggtattta taactatggg ttacgtgaag ttagtaaaaa tagagataga caagaaaaag
    13081 taaaatctat ctatgccaat ttgttcctga ttggttgttt aagtaatttt atagtagcgt
    13141 gtatatattt actttttata agattatctt t
//
