LOCUS       gnlProkkaBGJMNBAA_275  13786 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|BGJMNBAA_275.
ACCESSION   gnlProkkaBGJMNBAA_275
VERSION     gnlProkkaBGJMNBAA_275
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-16 23:56:55
            Original ID  :: gnl|Prokka|BGJMNBAA_275
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13786
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..864)
                     /locus_tag="ctg204_1"
                     /transl_table=11
                     /translation="MQTENFTLGKKELLILLGLTLVLPFPINWALIELNPLTLMAGADD
                     VPTWIGFGGSYIGGIIGGVISIMILNKTLQQTGVLHYDLKLLQLDTIIYTQQQDWFTGF
                     KQELAENLKSIDLYVLNMVVSSISMKNYAYAKEVLTEINKGLEYQMVAASFSFTSTHLS
                     SEEKKYMNLVRRVQTEYSSFIKDILYYIPLAETISSRKKLNYDQLMDYTLSQYDYLQGQ
                     EGESTASGAIIPRVMEIDPSDDIRKELERIMEERLTGRTYLYHLKSDLAEATHQLIIYE
                     ENRINSI"
     protocluster    1..13786
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[868:3298]"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      869..3298
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
     cand_cluster    1..13786
                     /SMILES="NC([*])C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /kind="single"
                     /product="NRPS-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13786
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS-like"
                     /region_number="1"
                     /rules="cds((PP-binding or NAD_binding_4) and (AMP-binding
                     or A-OX))"
                     /tool="antismash"
     CDS             complement(869..3298)
                     /NRPS_PKS="Domain: AMP-binding (12-401). E-value: 4.8e-83.
                     Score: 270.8. Matches aSDomain:
                     nrpspksdomains_ctg204_2_AMP-binding.1"
                     /NRPS_PKS="Domain: PP-binding (509-568). E-value: 2.7e-10.
                     Score: 32.6. Matches aSDomain:
                     nrpspksdomains_ctg204_2_PP-binding.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     257.4; E-value: 3.6e-78)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg204_2"
                     /sec_met_domain="AMP-binding (E-value: 2.2e-87, bitscore:
                     282.6, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 4.8e-11, bitscore:
                     32.6, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTNIQENLSRSLSTWGDKPAVVAKDGTVSYQMLERYSANIAQSI
                     RQRLSVTDPSGLRNICIGVCMERNKILVPAILAIFRLGATYLPIDPSLPDNRKRYMAEN
                     ADMVLLLTDSSNEVGGIPSVRQLYLNGEQLSEPVVGDYTEVLPNDCAYIIYTSGTTGNP
                     KGVRISYRNLDTFTRNLVDKKLYHLSDPANRYLAFASISFDASILELMMCIPVGGTLIL
                     AGEDERRDISLLDELIRREKVNIAFFPPSLLGMFADLDFPSFKTLLFGAEAIGEKLFNR
                     LKQQPYRLMNVYGPTENTVLSTIRIVGKDTSYDDIGYPLKGTVCYVLSENLQQITLGAT
                     GELCLGGPQVSLGYIGSVQLNEKSFISYDGERLYRTGDLVQQQPDGSIRFIGRKDTQVK
                     IRGFRIELTEIAERLNRDPDVERAHVVVVERNGRQLLGAYLQPSVSGNFHPEEVKERLR
                     AELPYYMIPNLWQVVDHFQRTINDKIDVRALPAFTSLELKYVPPVHPGEVILCGILKEM
                     LGLPQVSVEADLIDDLGLTSLDMLRLVTEANKKGCPINVSAVYTARNLRRLLLVPRQEP
                     IYWYRQQNLKKPVIILVCGSAYFNHLYFNLADRLYPKYDFLVVDAIYDHFNKVATDIPE
                     LLEYYVRTVQPMIRERTVYALTGFCMGAELAVGLAEMLHRSMGIMPKVFALDGQAWQNP
                     ALCQNYPLLVFPGDTDEMVRERNEIINIYFRTTPNLIYQGEVIVLLSGLFHQQAGLSPE
                     ESWTEENYRIFRTEYDNCERLWNKYYPNAPVLRLPADHWHFLEGESLEQLITVFLK"
     aSDomain        complement(1595..1771)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg204_2_PP-binding.1"
                     /evalue="2.70E-10"
                     /label="ctg204_2_PP-binding.1"
                     /locus_tag="ctg204_2"
                     /protein_end="568"
                     /protein_start="509"
                     /score="32.6"
                     /tool="antismash"
                     /translation="LCGILKEMLGLPQVSVEADLIDDLGLTSLDMLRLVTEANKKGCPI
                     NVSAVYTARNLRRL"
     aSModule        complement(1595..3262)
                     /complete
                     /domains="nrpspksdomains_ctg204_2_AMP-binding.1"
                     /domains="nrpspksdomains_ctg204_2_PP-binding.1"
                     /locus_tags="ctg204_2"
                     /monomer_pairings="X -> X"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(2069..2131)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg204_2_0004"
                     /evalue="1.50E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg204_2"
                     /protein_end="410"
                     /protein_start="389"
                     /score="36.2"
                     /tool="antismash"
                     /translation="FIGRKDTQVKIRGFRIELTEI"
     aSDomain        complement(2096..3262)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg204_2_AMP-binding.1"
                     /evalue="4.80E-83"
                     /label="ctg204_2_AMP-binding.1"
                     /locus_tag="ctg204_2"
                     /protein_end="401"
                     /protein_start="12"
                     /score="270.8"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="LSTWGDKPAVVAKDGTVSYQMLERYSANIAQSIRQRLSVTDPSGL
                     RNICIGVCMERNKILVPAILAIFRLGATYLPIDPSLPDNRKRYMAENADMVLLLTDSSN
                     EVGGIPSVRQLYLNGEQLSEPVVGDYTEVLPNDCAYIIYTSGTTGNPKGVRISYRNLDT
                     FTRNLVDKKLYHLSDPANRYLAFASISFDASILELMMCIPVGGTLILAGEDERRDISLL
                     DELIRREKVNIAFFPPSLLGMFADLDFPSFKTLLFGAEAIGEKLFNRLKQQPYRLMNVY
                     GPTENTVLSTIRIVGKDTSYDDIGYPLKGTVCYVLSENLQQITLGATGELCLGGPQVSL
                     GYIGSVQLNEKSFISYDGERLYRTGDLVQQQPDGSIRFIGRKDTQVKIR"
     CDS_motif       complement(2204..2290)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg204_2_0003"
                     /evalue="1.20E-08"
                     /label="NRPS-A_a6"
                     /locus_tag="ctg204_2"
                     /protein_end="365"
                     /protein_start="336"
                     /score="27.3"
                     /tool="antismash"
                     /translation="LGATGELCLGGPQVSLGYIGSVQLNEKSF"
     CDS_motif       complement(2792..2848)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg204_2_0002"
                     /evalue="1.50E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg204_2"
                     /protein_end="169"
                     /protein_start="150"
                     /score="26.8"
                     /tool="antismash"
                     /translation="AYIIYTSGTTGNPKGVRIS"
     CDS_motif       complement(3029..3070)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg204_2_0001"
                     /evalue="3.50E-03"
                     /label="NRPS-A_a2"
                     /locus_tag="ctg204_2"
                     /protein_end="90"
                     /protein_start="76"
                     /score="11.0"
                     /tool="antismash"
                     /translation="LAIFRLGATYLPID"
     CDS             complement(3311..5677)
                     /gene_functions="transport (smcogs)
                     SMCOG1082:TonB-dependent siderophore receptor family
                     (Score: 168.4; E-value: 5.9e-51)"
                     /gene_kind="transport"
                     /locus_tag="ctg204_3"
                     /transl_table=11
                     /translation="MKRCLLYILCCFGVVQLSAQPADNIRNSFVKAETFYESGDIDEAC
                     RILEENLSSFQGTMHTEACRLAALCCLALDRFPEAEKYVSLLLKDEPYYYISLQDPERF
                     ADMVRKHRETKVTLVTASQQVETPEEAPVPVTLITEEMIRAIHARCLRDVLIAYVPGIS
                     GLSSNEEMNLAMRGVYSPEQENILIMQDGQRLNSYITNAVSPDYGISLVKVKQIEVLRG
                     PASSLYGSVALTAVINIVTKDGVDVRNGSVSVSAGNRGQLAADLLLGKHDMNMDFMAWF
                     SLYRATGESVFVPAEKQYALYPRDGFIRLDNYSGFPAMDGGIKLQRGNLLFSFSMNYAK
                     KRQPYSMWLFSSPYSYERFRTFDGSGPGYSRWSAREQAVYSRTWQRITFNTAFYTDWNK
                     NVHYETSGDTLQDYPIFPNYDYQPIIYPTRGTFQYIRWMDFNVGFNGRVNYAYDWGKLG
                     KGNMLGGVEWNRYTLYDSEYLEGMNFKEIVRTWIEKRLYTGHEMNTDAFLQIKHNLHQN
                     WIVNAGIRYDYKRRSNKRTLQAFSPRLSLIYLRNGLNIKASYSRAFVDAPYYYRNNEMD
                     TYSGGENLQAEYLSSYQVTCAYHHSPSHIDVECNLFYNRASHFLFTQPETRVYENAGSL
                     DMGGVEVVARYKADRLSLDGNLCFQKVLNYTNFFVTDGSVNNVPGFSMNLVANYFLLKK
                     KVQSWSAHLKLNCSSHCYTQVSVLEDGLNGDATNYTIRLPGYAVFSFTTRYKYKRVEGS
                     LGIENLFNNRYECGGATVPIRQKGRWISASILYNF"
     CDS             complement(5674..6510)
                     /gene_functions="regulatory (smcogs) SMCOG1003:sensor
                     histidine kinase (Score: 141.1; E-value: 1e-42)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg204_4"
                     /transl_table=11
                     /translation="MEKNISQEKRIEELEARLKEQEKLGSLGLLSAGIAHEIQNPLNFV
                     INFSKLSGQLLADLADRVDEAKARIPEAELEDIKDILSGLRENVDKIKEHGDRAISIIR
                     GILLYSRGKEDEFMPTQIQKLTKEYVWLAYHAMRANYKNFNIAIREDYAKDIPSIRLIP
                     QDFSRAVLNVMNNACYAVWKKWQNAPEGYSPEIMVTLEKLDKRVVLSIRDNGEGMSPEV
                     KRKLFDSFFTTKPVGQGTGLGMAIVRDIIENKHHGKVLFDSVLHEYTCFRFIIPIA"
     CDS             complement(6533..9370)
                     /locus_tag="ctg204_5"
                     /transl_table=11
                     /translation="MKKIVFLIMCLCSVYANSQEGIPFFVNYPASVYQAHNRNFDVVCD
                     SCGNVYFANFEGILHYDYNRWETIYTPGFSRVTRLFRDSEGRIWVGGYNVFGRIERDGR
                     GCITLRTLLSDLDTNSLGELEDMAEIDKRIYLKATSGRYYTVQSDSILAPVQVLPAQLQ
                     EKWRNQSSVSMNRAFSLPGGETISINSAHGLIMDDSGKKERFSVTERNGLCSNAVSGIA
                     ADGRGNLWGATDNGVFHVFIPSLFSRYTSGEGLKGEVISAVSYKGMIYTGTLQGLYVLK
                     QNTFVPVQGISQACWQLCLSPQGELYAASGDGVYVIRDYNHSEKLTDMAAYSLTFIGHT
                     NLLMGTMDGIYQYSADEERIKKISDVEKVVRLEVKKDRSVWAKTLYGEIYLREEGKSSF
                     VLQDRESEEIMTEYTDNDGCHWQTNLKGKEVQVHHSQIDTEKFNQCLYAIRNYVVRVIY
                     IEEDRAAWFGGDFGLIRMDLEKARTFTPVVPRIYLREVCLNRDSVYWGGDLPEESGGAD
                     WQINSTVPRLGNDVRSIRFSFATDAPCFTGSNEYRYRLVGYDPEWSSWDSGTVKEYANL
                     SSGTYTFCVRARDIYGTESEMKQFRFSLLPPFYLQWYCLILYTVAFGMLLFVLFKWRMR
                     SLLKEKERLEALVGQRTKQLVQQKNEIEEKSLKLEKALKELGQAQDELVRQEKMATVGK
                     LTQGLIDRILNPLNYINNFSHLTSGLLKDLYQNLESVKELLDEDTYLDSVDVINMMRDN
                     LEKIEEHGSNTTRVLKAMEEILRDRNRQLEKTELIGLCRKDMELLSSYYQKEITAMHIA
                     VRTSLPDNPLFIDGNAEQLGKTIMSLLNNGMYAIAKKYGKKAYPAEIGLALESKDGQAV
                     IRLYDNGVGIEQSILDKIFDPFFTTKTTGEAAGIGLYLSKEIILNHHGQIAVRSEKDEL
                     TEFTITLPLWEEKSV"
     CDS             complement(9367..10968)
                     /locus_tag="ctg204_6"
                     /transl_table=11
                     /translation="MIKLNENIIRWIIAVPCILLTVCLVLYRAYRHSASDRERLALSLE
                     EFRDKEKKSVLIQRVSQQMEEIAYQQKDISEKRRQEAVAQTQKANRMQQQAELARERAL
                     AAQLEAEKAYRMADEQKNLAMERQLQAEQSKRVADTLAFLALGRSLGTLSVTQYRSGNM
                     ELASLLAYTAWWFTKRYDGDVYHPAVFNALSLSCRQDQLWFGHKGAVTGIKLLSGGEEK
                     ARAGRNPLPGLVTVGKYGEMIRWKSENGQTYTSELLLNDPCYDFRDVLLRSDSQMYALS
                     YCGQLISTDSAGIVTRFLPKGEYRQLISIASNLVLAVSTTGIYSFDCINHEIQPYFQPE
                     HSITCVGQMEGYLYVFFKNGTVALLSSDGTFLRFIDSLPENSVVTAFCPLTNERYAIGC
                     REGVILICDKNGNIRQKLIGHQAAVTAISRKGNKLFSSSYDCTLRLWDLRKGKTESAVI
                     VTSPGWIHTFCFHPDGTSVFIGDEQGRLYRVPVSPDHMATVVRQGLQRDFTREEWEYYI
                     GKQIPFESYYLKTYQP"
     CDS             complement(10965..11393)
                     /locus_tag="ctg204_7"
                     /transl_table=11
                     /translation="MTLLQFRPVDGRLDEILSMLMHSREVASHPSLSYAIRLVSEEIIV
                     NILNYAYPQQAEGYLTLCLWDEDGEITLEFIDGGIPFNPLDKADPDISLPLEQREIGGL
                     GIFLVREMMDDVAYTYVNKENRLTIKKKYLQPTDEPVS"
     CDS             complement(11408..11713)
                     /locus_tag="ctg204_8"
                     /transl_table=11
                     /translation="MEKYEIHFVGSVLDSNTSGDEQAKIVALIEQGHSVALDLSGCSYV
                     SSAGLRVMLYAFKLAKAKSRDVCLVGVSQEVKDVMHMTGFDKFFRFYQTLDELSQP"
     CDS             complement(11732..12901)
                     /gene_functions="other (smcogs) SMCOG1054:hypothetical
                     protein (Score: 219.1; E-value: 2.2e-66)"
                     /gene_kind="other"
                     /locus_tag="ctg204_9"
                     /transl_table=11
                     /translation="MAVKILSVDDELDLEVLLTQYFRRQIRKGEYEFAFAHNGLEALQK
                     LLETPDFDIILSDINMPEMDGLTLLAKVNELKNPAMKCIMVSAYGDMDNIRSAMNKGAF
                     DFATKPIDLDDLSRTIEKAIEQVRYIRESQQEHNQLESIKNDLAIAGEIQQTILPRSFP
                     PFPELTEVVDIYASMTPAKDVGGDFYDFFQIDDERIGLVIADVSGKGVPASLFMAVSRT
                     LLRATALRGVSSAECLTYANKLLCKESLDSMFVTVFYGIYHYKTGMMDYTNAGHNPPYL
                     LRGGRTVECLPVASNFVVGVFDDIEFESNTLTFGIGDTLLLYTDGVTEAFNDKREQFSE
                     SNLQDILASMHESSSAKEVVTSVLQSVKTFSGDYPQSDDITLLSLQRIK"
     CDS             13249..13785
                     /locus_tag="ctg204_10"
                     /transl_table=11
                     /translation="MLIILKQDDSCQVAQTTCTTNSLEIRYKDYSVLKKTLDLNTKSIN
                     SNSCIELIIYGTHGNEKEICKLTKPDIKDLSYFFKGKVCRLVLDACHSACHIPHFKEML
                     TDDGIILCHVGICQVNSIETKTGKDTYERWINGNKEGLKVWSDGIVPAIYTRKNNTLTY
                     YECSKFEVDINHPFTG"
ORIGIN
        1 aatagagttt atacggttct cttcataaat aattaattga tgcgtagcct ctgcaagatc
       61 tgacttcagg tgatacaaat aggtacgccc ggttaatctt tcttccatta tccgttctag
      121 ttctttccgt atatcatcag atggatcgat ttccataaca cgcggtatga tggctcccga
      181 agctgtagac tccccttcct gaccttgcaa ataatcatat tgggacaaag tatagtccat
      241 cagctgatca tagtttagtt ttttcctgga agatatcgtt tctgccaaag gaatatagta
      301 aagaatatcc ttgataaaag agctatattc agtctgtacg cggcgtacca gattcatata
      361 ctttttttct tcggatgata aatgcgtaga agtgaaagaa aaggatgcgg caaccatctg
      421 atattcaagc cctttattga tttctgtcaa cacctctttg gcatatgcat agtttttcat
      481 ggatatagac gaaacaacca tattcaacac atacaaatca atagatttga gattctctgc
      541 cagttcttgt ttgaaaccgg taaaccaatc ttgttgctga gtataaatta tggtatctaa
      601 ctgcaggagt ttcaaatcgt aatgaagtac acctgtctgc tgaagtgtct tgttcagaat
      661 cataattgag atgacccctc cgatgattcc tccaatataa ctgccgccga aacctatcca
      721 ggtgggcaca tcgtctgcac ccgccatcag agtcaacgga ttcagttcga ttaatgccca
      781 attgattgga aaaggcagta caagagtcaa gccaagtaaa ataagaagct ctttcttacc
      841 taaagtgaag ttttcagtct gcataaatct acttcaaaaa cacagttatt aattgttcca
      901 atgattcccc ttctaaaaag tgccaatgat ctgccggcaa tcgcaaaaca ggagcgttcg
      961 gataatattt attccataat ctttcgcaat tgtcatattc tgtccggaat atacgatagt
     1021 tttcctccgt ccacgactct tcaggagaca atcccgcctg ttgatggaac aatccggaca
     1081 gcaaaacaat aacctctccc tgataaatca gattaggagt ggttcgaaaa taaatattta
     1141 tgatttcgtt ccgttcacgt accatttcat ctgtatctcc gggaaatacc aacaaaggat
     1201 aattttgaca gagagccgga ttttgccaag cctgtccatc cagagcaaaa acttttggca
     1261 ttatccccat ggagcgatgt aacatttcgg ccaggccgac agccagttca gctcccatac
     1321 agaagccggt aagcgcatag acggtacgct cccggatcat tggctgaacc gtccggacat
     1381 aatattccaa cagttccgga atatccgtag caactttatt aaaatgatcg tagatagcat
     1441 ctacaactag aaagtcatat ttgggataaa ggcggtcggc caaattaaag tacaaatgat
     1501 taaaataggc agatccacaa accagaatga ttacgggttt cttcaggttt tgctgcctgt
     1561 accaatagat aggttcttgc cgcggaacga gcaataatcg gcgcagatta cgggcagtat
     1621 aaactgcaga tacgttgatg ggacatcctt ttttattggc ctcggtaaca agcctcaaca
     1681 tatccagcga agttaatccc agatcatcaa tcaaatcggc ctcaacactg acttgaggca
     1741 aacctaacat ttccttcaaa attccacata agataacctc gcccggatga acaggaggaa
     1801 catacttcaa ctccaatgaa gtaaaagccg ggagcgcccg gacatcaatc ttatcattta
     1861 tagtacgctg aaaatgatct accacctgcc ataaattggg tatcatgtag taaggaagtt
     1921 ctgcacgcaa acgctctttg acctcttccg gatgaaagtt accggagact gagggttgca
     1981 aataagctcc caataattga cgcccattcc gctcaacaac tactacgtgg gctctctcca
     2041 cgtccggatc tctattcaat cgttctgcta tttcagtcaa ttcgatacga aaaccacgta
     2101 tcttgacctg agtatctttt cgcccgataa accgtattga accgtccggt tgctgctgta
     2161 ccaagtcacc tgtcctgtac aaccgttctc catcgtacga gatgaatgat ttttcattca
     2221 gctgaacact cccaatatat cccagcgaaa cctgaggtcc tcccaagcaa agttctcctg
     2281 tagccccaag agttatctgt tggaggtttt cagacaaaac ataacagaca gttcccttga
     2341 gcggatagcc aatatcgtca tacgatgtat ctttgcctac aatccgtatg gtactgagta
     2401 cggtattctc tgtcggtcca tatacattca tcaaccggta aggctgctgt ttcagcctgt
     2461 taaataactt ttcaccaata gcctccgcac caaagagcag agtcttaaag gatggaaagt
     2521 caagatcggc aaacatgccc agcaacgaag gagggaaaaa agcaatattc accttctcgc
     2581 gcctgatcag ttcgtctagt aaagaaatat ctctgcgttc gtcctcaccg gccaggatca
     2641 atgttcctcc gaccggaata cacatcatca gttctaatat ggaagcatca aaactgatac
     2701 tcgcaaacgc cagatacctg tttgccggat cagacaaatg atacaatttc ttatctacca
     2761 gattcctcgt aaatgtatcc agattccgat aactaatacg tacacctttg ggattgcctg
     2821 ttgttccgga agtatatata atataggcgc aatcattggg aagaacttca gtatagtcac
     2881 caacaaccgg ttcggatagt tgctccccat tcaggtaaag ttggcggacg gacgggattc
     2941 cacctacttc attcgatgaa tcggtcaaca acaaaaccat atccgcattt tcagccatat
     3001 accgtttacg attatccggc agcgagggat ctatcggtaa ataagttgcc cctaaccgga
     3061 aaatagccag aatggcaggt actaaaattt tgtttcgttc catacaaact ccgatacaga
     3121 tattccgaag tccggacgga tcagttaccg ataaacgttg acggatagat tgtgctatat
     3181 tggcagagta acgttccagc atttgataag agacggtacc gtcttttgca acgaccgccg
     3241 gtttgtcacc ccaggtagag agtgatcgag aaagattttc ttgaatgttt gttttcatta
     3301 ttagtttgat ttagaaatta tacaatatac tggcggaaat ccaccttcct ttctggcgga
     3361 taggaacagt cgctcctccg cattcatatc ggttattgaa aagattctca atgcccagac
     3421 tgccttctac ccttttatac ttatatctgg tagtgaaaga aaagacagca taaccgggca
     3481 aacggattgt gtaattcgtc gcatctccat tgagtccatc ttccaataca cttacctgag
     3541 tgtagcagtg gctactgcaa ttcaatttta aatgggcaga ccagctctgt actttctttt
     3601 taagtaaaaa gtagtttgct acaagattca tagaaaagcc gggtacgtta ttcacagatc
     3661 catcggtaac aaaaaaattg gtataattca atactttctg aaaacacagg tttccatcca
     3721 ggctcagtcg gtctgcctta taacgggcaa cgacctcgac acctcccata tccagagaac
     3781 cggcattttc ataaacacgt gtttccggct gtgtgaacag gaaatgggac gcccgattat
     3841 aaaataaatt acactctaca tctatatgtg aaggtgaatg atgataagca caagtcacct
     3901 gatatgaact tagatattca gcttgcagat tttcgccacc cgaataggta tccatttcat
     3961 tgtttctgta ataatagggc gcatcgacaa atgctctgga ataactggct ttgatattta
     4021 atccgttcct gagataaatc agtgacagac ggggagaaaa agcctgtaat gtccgcttat
     4081 tacttcgccg tttatagtca tacctgatgc cggcattgac aatccaattt tgatgcaggt
     4141 tgtgtttaat ctgaagaaag gcatccgtgt tcatctcgtg tcccgtgtaa agtcgttttt
     4201 cgatccacgt cctgacgatc tctttaaaat tcataccttc caaatactcg gaatcataaa
     4261 gcgtataccg attccattcc acaccgccaa gcatattgcc tttccccagc ttcccccaat
     4321 cataggcata gtttacacgc ccattaaagc ctacgttaaa atccatccaa cggatgtatt
     4381 gaaatgttcc gcgagtcgga taaataatag gctgataatc atagttagga aaaataggat
     4441 agtcttgtaa agtatctccc gaggtttcat aatgtacgtt tttattccaa tcggtataaa
     4501 atgcggtatt gaaagtgatc cgctgccacg tgcggctata aacagcctgt tctcttgccg
     4561 accatctgga atatcccggg ccggaaccgt caaaagtacg aaaccgctca taagaatatg
     4621 gagaagaaaa gagccacatg ctataaggtt gccttttctt cgcgtaattc atactgaaac
     4681 taaaaagcaa atttccacgt tgcaatttaa ttcctccatc catggcagga aatcccgaat
     4741 aattgtccag acggatgaat ccgtccctag ggtaaagagc atattgtttt tcggccggga
     4801 caaaaaccga ttctcccgtt gcacggtaca aggagaacca tgccataaag tccatgttca
     4861 tgtcgtgctt tcccaatagc aggtcagcag ccaactggcc ccgattaccg gcactgacag
     4921 atacggaacc attacgaaca tccaccccgt ctttagtaac tatattaatc acggctgtca
     4981 aagccacact gccataaagc gaagaagccg gtccgcgcag cacctctatt tgtttgactt
     5041 ttaccagact aataccataa tccggcgaaa cagcattagt aatataactg ttcagacgtt
     5101 gtccatcctg cataatcaat atgttctcct gttcgggaga atataccccg cgcatagcca
     5161 gattcatctc ttcattggaa gacaaaccgg atataccggg cacataagct atcagtacat
     5221 cccgcaggca ccgggcatgg atagcccgta tcatctcctc cgtaattaaa gtaacaggca
     5281 ccggagcttc ttccggggtc tctacctgtt gtgaggctgt gaccagagtt actttagtct
     5341 ccctgtgttt ccttaccata tccgcaaagc gttccggatc ttgaagcgag atataataat
     5401 aaggttcgtc tttcaataac agcgaaacat acttttccgc ttccgggaag cggtctaaag
     5461 ctaaacagca taatgcagcc aaacggcacg cctcggtatg catcgtacct tgaaaagacg
     5521 acagattctc ctccaagata cgacaagctt catcgatatc tccgctctca taaaatgttt
     5581 ccgcctttac aaacgaatta cggatgttat ccgccggctg agctgacagt tgcacaaccc
     5641 caaaacagca aaggatatat agcagacagc gtttcatgcg ataggaatga taaaccggaa
     5701 acaagtatat tcatgcagga ccgaatcaaa caatactttt ccatggtgtt tgttttctat
     5761 aatatcacga acgattgcca taccaaggcc tgtcccctgc cccaccggtt ttgttgtgaa
     5821 aaaagagtca aatagttttc gtttgacctc cggactcatg ccctctccgt tatcacgaat
     5881 agaaagtaca actcttttat ccaacttttc taaggtcacc attatctcgg gggaatatcc
     5941 ttcgggagca ttctgccatt ttttccatac tgcatagcag gcattattca tcacattcaa
     6001 gactgcccga ctgaaatcct gcgggatcag ccggatcgag gggatatctt tagcataatc
     6061 ttcacggata gcaatattga aattcttata attggcccgc atggcatgat aagccagcca
     6121 cacatattcc ttagtcaatt tttgtatttg tgtaggcatg aattcgtctt ctttccccct
     6181 ggagtaaagc aaaataccac gaataatgct gatagcccga tcaccatgct ctttgatttt
     6241 gtccacattc tctctcagcc cggaaagtat atctttgata tcttccagtt ccgcttccgg
     6301 aatacgagct tttgcttcat ccaccctatc ggccaggtcg gccaacaatt gaccggacag
     6361 tttactgaaa ttgatgacaa aattcaaagg attctgtatc tcgtgtgcaa tgcctgcact
     6421 caacaagccc aatgatccca gcttttcctg ctctttgagc cgtgcttcca actcttcaat
     6481 tcgtttctct tgtgaaatgt ttttttccat aatcaatctg ttctatgttt atttatactg
     6541 acttttcctc ccacaatggc agagtgatag tgaattctgt caattcatct ttttcagaac
     6601 gtactgctat ctgcccatgg tgatttaata tgatttcctt actcagatac aaaccgatac
     6661 ctgctgcctc tccggttgtt ttggtagtaa agaacggatc gaagatttta tccagaatac
     6721 tctgctcgat ccccactcca ttgtcatata ggcgaatgac tgcctgtccg tccttacttt
     6781 ccaatgccag gccaatctct gccggatagg ctttcttacc gtattttttg gctatggcat
     6841 acataccatt gttaagaaga ctcataatgg tttttcccag ttgttcggca ttcccgtcaa
     6901 taaacaacgg attatcgggc aaggaagtac gaaccgcaat gtgcatagcc gtaatctcct
     6961 tctgataata actgctcaat agctccatgt ctttccggca taaaccgatt aattctgttt
     7021 tttccagttg cctgttacgg tctctcagga tttcttccat ggccttcagt acacgagtgg
     7081 tgttacttcc atgttcctca atcttttcca gattatctct catcatgttg atgacatcta
     7141 ccgaatccaa gtaggtatct tcatccaaaa gttcttttac actctccaga ttctgatata
     7201 gatccttcag taatcctgag gtcaggtggg aaaaattatt aatgtaattc aacggattca
     7261 gaatacggtc aatcaaccct tgagtcagtt tgcctacagt agccattttt tcttgtcgaa
     7321 ccaattcatc ttgtgcctgg cccagctcct tcaatgcttt ttccaatttt aaggactttt
     7381 cctcaatttc atttttttgt tgtaccaact gtttggtacg ttggccgaca agggcctcta
     7441 acctctcctt ctctttcagc aaactgcgca ttctccattt aaacaatacg aacaacagca
     7501 tcccaaaagc aacggtatat aggatcagac aataccattg caaataaaaa ggaggcaata
     7561 acgaaaagcg gaattgtttc atttcactct ctgtaccgta aatatcacgg gcccggacac
     7621 aaaacgtata cgtacccgac gaaaggttgg catactcttt cacagtcccg gaatcccacg
     7681 aactccattc cggatcataa ccgaccaggc gatatctata ctcattggaa ccggtgaaac
     7741 agggcgcatc ggtagcaaat gaaaaacgaa tggaacgtac atcattcccc aaacgaggta
     7801 ctgtactatt tatctgccag tccgctcccc cggactcttc cggcaaatct cctccccaat
     7861 agacagaatc acggttcaga caaacttcac gaagatagat gcggggaaca accggagtaa
     7921 atgtccgggc cttttcaagg tccatccgaa ttaaaccaaa atcaccgcca aaccatgccg
     7981 ccctgtcttc ttcaatataa atcaccctca cgacataatt ccgaatggca tacaggcatt
     8041 ggttgaattt ctccgtatca atttgcgaat gatgtacctg tacctctttt cctttcagat
     8101 ttgtctgcca atgacagcca tcgttgtccg tatactcggt cattatttct tcactctctc
     8161 tgtcttgaag tacaaaagag cttttgccct cttcccgcaa atagatttct ccgtacaacg
     8221 ttttagccca tacagaacga tctttcttca cttccagacg aacgactttt tcgacatcgg
     8281 aaattttctt tatccgttcc tcatctgccg aatattgata aatcccatcc atagtgccca
     8341 tcagaaggtt cgtatgccca atgaatgtca atgaataagc tgccatatct gtgagttttt
     8401 ccgaatgatt ataatcccgg atcacataca caccatcgcc ggacgctgca tataattctc
     8461 cttgtggaga aagacacagt tgccaacatg cttgcgaaat tccctgaaca ggaacaaaag
     8521 tgttttgctt caatacgtat aatccctgta aggtcccggt atatatcatt cctttgtaag
     8581 agacagccga tattacctct cccttcagac cttcaccaga ggtataacgg ctgaacaaag
     8641 agggaataaa aacatgaaac acaccgttat ccgtagctcc ccagaggttg ccacgcccat
     8701 cggccgcaat acccgaaaca gcgttactgc ataagccatt tctctcagtt acggaaaacc
     8761 gttctttttt cccactgtca tccattatta atccatgggc agagtttatc gagattgttt
     8821 ctcctccggg tagagaaaac gcccgattca ttgagactga ggattgattt ctccactttt
     8881 cctgcaattg ggccggaagt acctgaaccg gtgccaaaat ggaatctgac tgaaccgtat
     8941 aatatcttcc tgatgtagct ttcagataaa tgcgtttatc tatttctgcc atatcttcca
     9001 attcgcccaa agagtttgtg tccagatcgg aaagaagggt tctcaacgta atacatccgc
     9061 gtccatcacg ctctatccgt ccgaacacgt tatatcctcc cacccatatc ctaccttccg
     9121 aatcacgaaa caaacgggtg acacgggaaa aacccggtgt ataaatagtt tcccaacggt
     9181 tatagtcata atgaaggata ccttcgaaat tagcaaaata gacatttcca caactgtcgc
     9241 aaacgacatc gaaattacga ttgtgcgcct gataaaccga agccggatag tttacaaaaa
     9301 acgggatacc ttcttgtgaa tttgcatata ccgagcaaag acacattatc aaaaagacta
     9361 tctttttcat ggctgatacg tttttaggta ataggattca aatggaattt gcttaccgat
     9421 ataatactcc cattcttctc gagtaaaatc acgctgtaac ccctgacgga caacagtagc
     9481 catgtgatcg ggtgaaacag gcacccgata caaccgcccc tgttcgtctc ctataaagac
     9541 agatgtaccg tccggatgaa agcaaaaagt atggatccaa ccggggcttg tcacaataac
     9601 ggccgactcg gtctttcctt tacgaagatc ccacagacgc agcgtacaat cgtaactact
     9661 cgaaaacagt ttgttccctt tccgggaaat agcagtaacc gcagcctgat gccctatcaa
     9721 cttctgccgg atatttccat tcttatcaca aatcaggatg actccttcac gacagccaat
     9781 ggcatatctt tcattggtaa gaggacagaa tgcagtaacc acactattct cgggcaagct
     9841 gtctataaat ctgagaaatg taccatccga cgaaagtaaa gctactgtcc cattcttaaa
     9901 aaaaacatag agatagcctt ccatttgacc gacacaagtt atcgaatgtt ccggctgaaa
     9961 ataaggttgt atctcatggt tgatacagtc aaaagaataa ataccggttg tggaaactgc
    10021 caataccaag ttagaggcaa tcgaaatcaa ttgccgatat tctcctttag gcaaaaagcg
    10081 ggtaacgata ccggcggaat ccgtggagat aagctgcccg cagtatgaca aggcatacat
    10141 ctgtgaatcg gaccgcaaca gcacatcccg aaaatcataa cagggatcat tcaacagtaa
    10201 ttcggaggta taggtctgcc cattttccga tttccaacgt atcatctcac cgtacttgcc
    10261 gacagtgacc aatcccggca gaggattccg accggctctt gctttttcct cgcctccgga
    10321 taacagtttg atcccggtaa cagctccttt atgcccgaac caaagctgat cttgcctaca
    10381 agacaaagac aatgcattga aaacagccgg atgatataca tcgccatcat atcgcttggt
    10441 aaaccaccag gcggtatatg ccaacagaga agctaattcc atgttgcccg accgatattg
    10501 agtaacagaa agtgtcccca atgaacgtcc caaagccaga aaagccaatg tatcggcaac
    10561 cctcttcgac tgttcggcct gtagttgccg ttccatcgcc agattctttt gttcatctgc
    10621 catccgatac gctttctcag cctccaattg tgcagcaagc gctctttccc gtgccaactc
    10681 tgcctgctgt tgcattcggt tggccttttg agtttgcgca acggcttcct gtcttctctt
    10741 ttcggaaata tccttttgtt gataagcaat ctcctccatt tgttgactga cccgttgtat
    10801 aagaaccgat ttcttttctt tatcccggaa ttcctccaga gacagagcaa gacgctccct
    10861 gtccgatgcc gaatgacgat atgcccggta taggaccaga catactgtca aaagtataca
    10921 aggaacggca atgatccaac ggatgatatt ttcgtttaac ttgatcatga tacaggttca
    10981 tcagtgggtt gcagatattt ctttttaatg gtcaaccgat tctccttatt cacgtacgta
    11041 tacgctacgt catccatcat ttcacgtacc aggaaaatgc ccaatcctcc tatttcacgt
    11101 tgttctaacg gtaatgaaat atcaggatcg gctttatcca aaggattgaa tggaatacca
    11161 ccatctataa actccaaagt aatctctccg tcttcatccc ataagcacag agtcagataa
    11221 ccttctgcct gctgcggata agcgtaattg agaatattga caatgatctc ctcactgacc
    11281 aaacggatgg cataagacag ggaaggatgt gaagcaactt cacgactatg catcagcata
    11341 ctaagaattt catctaacct cccatcgaca gggcgaaact gaagtaacgt cattgctcag
    11401 gtaattttta gggttgtgat aattcatcga gagtctgata aaaacgaaag aatttatcga
    11461 atccggtcat gtgcatcacg tctttaacct cttgtgacac accgacaagg caaacatctc
    11521 tacttttagc tttcgccagc ttaaaggcat aaagcatgac tctcaatccg gcactggata
    11581 cataagaaca gccgctgaga tctaatgcaa cagaatgtcc ttgctcgata agagctacaa
    11641 tttttgcttg ttcgtcaccg cttgtatttg aatccaagac ggaacctaca aaatgaattt
    11701 catacttttc catcgttctt ttattttaat attatttgat tcgttgaaga gaaagcaggg
    11761 ttatgtcatc ggactgagga tagtctccgg agaaagtctt aacagactgc aatacactcg
    11821 taacaacctc ttttgcggaa ctactttcgt gcatagacgc caatatatcc tgtaagttac
    11881 tttccgagaa ttgttcccgc ttgtcgttaa aagcctctgt gacaccatcc gtatacagaa
    11941 gtaaagtgtc accgatgccg aacgtcaatg tattactctc aaattcaata tcatcgaaca
    12001 cgcctaccac aaaattagaa gcgacaggca agcattcaac agtccgtccg ccgcgaagga
    12061 gataaggggg attatgcccg gcattggtat agtccatcat gccggtttta taatgataaa
    12121 tcccataaaa gaccgtaaca aacatagagt ccaggctctc tttacacagt aacttattgg
    12181 cataagtaag gcattctgcc gacgaaacac cccgaagagc agttgcacgg agcagggtcc
    12241 gactaaccgc catgaacaag gatgccggca cccctttccc agatacgtca gcaatcacca
    12301 gcccgatacg ttcatcgtca atctggaaga aatcataaaa atcgccacct acatcttttg
    12361 ccggagtcat ggaagcataa atatcaacca cttccgtcag ttccggaaaa ggaggaaagg
    12421 aacggggaag aatcgtttgc tggatttctc ccgcaatggc caggtcattt ttgatagatt
    12481 ccagttggtt gtgctcctgc tgtgactcac ggatatagcg aacctgttcg atcgcctttt
    12541 caatagtccg cgacagatca tccaaatcga tcggtttggt tgcaaaatca aacgctccct
    12601 tgttcatagc agaacgtatg ttatccatgt ctccataagc agagaccatt atacacttca
    12661 ttgccggatt tttcagttca ttgaccttag ccaatagggt caacccatcc atctccggca
    12721 tattaatatc actcaggatg atatcgaaat cgggagtttc cagaagtttc tgtaaagctt
    12781 ccaacccgtt atgggcaaaa gcgaactcat attcaccttt tcgtatttgt cgcctgaagt
    12841 actgggtaag taatacttct aaatcgagtt catcatctac actcaatatt tttactgcca
    12901 tatctattgt tatttatgaa tttcaaccgt ttgttctgac gtttatgatg gcaaaaatag
    12961 agagtgatcg acccggttac aattttatat tttaaacagg aagaatgttt ttccgaatgg
    13021 acgatattgt cttataagca tacaggtata ttgctttcgt ggcttagaag acagcacttg
    13081 aaagattgat ttacactcct gaaagaaact attccgtatt cagaatttat atttttaaga
    13141 tggaactttt cttctcactt ttgtcaccgt aagcttacaa agaataaata gaaacggcgg
    13201 attccgaaaa gccgaagaaa gagtaggaac tttttacaaa tcactattat gcttattatt
    13261 ttaaaacaag atgatagttg tcaagttgca caaacgacat gtacaacaaa ctctttagaa
    13321 atccgataca aagattatag tgtactgaaa aaaactctgg atttgaacac aaaatctatt
    13381 aatagcaata gctgtataga gttaattatt tacggaacac acggaaatga aaaggaaatt
    13441 tgcaaactaa ccaaaccaga cataaaagat ctgagctatt tcttcaaagg aaaagtttgt
    13501 agattagttc ttgatgcttg ccatagcgcc tgccatattc cacatttcaa agagatgtta
    13561 acagatgatg gaatcatatt atgtcatgta ggtatctgcc aagtaaacag catcgaaact
    13621 aaaacaggta aagacaccta tgaacggtgg ataaatggca ataaggaagg attaaaagta
    13681 tggtcggatg gaatcgttcc agctatctat actcgaaaga ataacacttt aacttactac
    13741 gaatgtagca aattcgaagt agatattaat caccctttta ccggaa
//
