LOCUS       gnlProkkaFPBICPHB_187  13800 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|FPBICPHB_187.
ACCESSION   gnlProkkaFPBICPHB_187
VERSION     gnlProkkaFPBICPHB_187
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-30 19:26:43
            Original ID  :: gnl|Prokka|FPBICPHB_187
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13800
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13800
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[901:3331]"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      902..3331
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
     cand_cluster    1..13800
                     /SMILES="NC([*])C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /kind="single"
                     /product="NRPS-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13800
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS-like"
                     /region_number="1"
                     /rules="cds((PP-binding or NAD_binding_4) and (AMP-binding
                     or A-OX))"
                     /tool="antismash"
     CDS             complement(4..897)
                     /locus_tag="ctg168_1"
                     /transl_table=11
                     /translation="MQTENFTLGKKELLILLGLILVLPFPINWALIELNPLTLMAGADD
                     VPTWIGFGGSYIGGIIGGVISIMILNKTLQQTGVLHHDLKLLQLDTIIYTQQQDWFTGF
                     KQELAENLKSIDLYVLNTVVSSISMKNYAYAKEVLTEINKGLEYQMVAASFSFTSTHLS
                     SEEKKYMSLVRRVQTEYSSFIKDILYYIPLAETISSRKKLNYDQLMDYTLSQYDYLQGQ
                     EGESTASGAIIPRVMEIDPSDDIRKELERIMEERLTGRTYLYHLKSDLAEATHQLIIYE
                     ENRINSILHKPEREMN"
     CDS             complement(902..3331)
                     /NRPS_PKS="Domain: AMP-binding (12-401). E-value: 3.3e-83.
                     Score: 271.4. Matches aSDomain:
                     nrpspksdomains_ctg168_2_AMP-binding.1"
                     /NRPS_PKS="Domain: PP-binding (509-568). E-value: 2.7e-10.
                     Score: 32.6. Matches aSDomain:
                     nrpspksdomains_ctg168_2_PP-binding.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     259.3; E-value: 9.5e-79)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg168_2"
                     /sec_met_domain="AMP-binding (E-value: 7.5e-88, bitscore:
                     284.2, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 4.8e-11, bitscore:
                     32.6, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTNIQENLSRSLSTWGDKPAVVAKDGTVSYQMLERYSANIAQSI
                     RQRLSVTDPSGLRNICIGVCMERNKTLVPAILAIFRLGATYLPIDPSLPDNRKRYMAEN
                     ADMVLLLTDSSNEVGGIPSVRQLYLNGEQLSEPVVGDYTEVLPNDCAYIIYTSGTTGNP
                     KGVRISYRNLDTFTRNLVDKKLYHLSDPANRYLAFASISFDASILELMMCIPVGGTLIL
                     AGEDERRDISLLDELIRREKVNIAFFPPSLLGMFADLDFPSFKTLLFGAEAIGEKLFNR
                     LKQQPYRLMNVYGPTENTVLSTIRIVGKDTSYDDIGYPLKGTVCYVLSENLQQTTLGAT
                     GELCLGGPQVSLGYIGSVQLNEKSFISYDGERLYRTGDLVQQQPDGSIRFIGRKDTQVK
                     IRGFRIELTEIAERLNRDPDVERAHVVVVERNGRQLLGAYLQPSVSGNFHPEEVKERLR
                     AELPYYMIPNLWQVVDHFQRTINDKIDVRALPAFTSLELKYVPPVHPGEVILCGILKEM
                     LGLPQVSVEADLIDDLGLTSLDMLRLVTEANKKGCPINVSAVYTARNLRRLLLVPRHEP
                     IYWYRQQNLKKPVIILVCGSAYFNHLYFNLADRLYPKYDFLVVDAIYDHFNKVATDIPE
                     LLEYYVRTVQPMIRERTVYALTGFCMGAELAVGLAEMLHRSMGIMPKVFALDGQAWQNP
                     ALCQNYPLLVFPGDTDEMVRKRNEIINIYFRTTPNLIYQGEVIVLLSGLFHQQAGLSPE
                     ESWTEENYRIFRTEYDNCERLWNKYYPNAPVLRLPADHWHFLEGESLEQLITVFLK"
     aSDomain        complement(1628..1804)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg168_2_PP-binding.1"
                     /evalue="2.70E-10"
                     /label="ctg168_2_PP-binding.1"
                     /locus_tag="ctg168_2"
                     /protein_end="568"
                     /protein_start="509"
                     /score="32.6"
                     /tool="antismash"
                     /translation="LCGILKEMLGLPQVSVEADLIDDLGLTSLDMLRLVTEANKKGCPI
                     NVSAVYTARNLRRL"
     aSModule        complement(1628..3295)
                     /complete
                     /domains="nrpspksdomains_ctg168_2_AMP-binding.1"
                     /domains="nrpspksdomains_ctg168_2_PP-binding.1"
                     /locus_tags="ctg168_2"
                     /monomer_pairings="X -> X"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(2102..2164)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg168_2_0004"
                     /evalue="1.50E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg168_2"
                     /protein_end="410"
                     /protein_start="389"
                     /score="36.2"
                     /tool="antismash"
                     /translation="FIGRKDTQVKIRGFRIELTEI"
     aSDomain        complement(2129..3295)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg168_2_AMP-binding.1"
                     /evalue="3.30E-83"
                     /label="ctg168_2_AMP-binding.1"
                     /locus_tag="ctg168_2"
                     /protein_end="401"
                     /protein_start="12"
                     /score="271.4"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="LSTWGDKPAVVAKDGTVSYQMLERYSANIAQSIRQRLSVTDPSGL
                     RNICIGVCMERNKTLVPAILAIFRLGATYLPIDPSLPDNRKRYMAENADMVLLLTDSSN
                     EVGGIPSVRQLYLNGEQLSEPVVGDYTEVLPNDCAYIIYTSGTTGNPKGVRISYRNLDT
                     FTRNLVDKKLYHLSDPANRYLAFASISFDASILELMMCIPVGGTLILAGEDERRDISLL
                     DELIRREKVNIAFFPPSLLGMFADLDFPSFKTLLFGAEAIGEKLFNRLKQQPYRLMNVY
                     GPTENTVLSTIRIVGKDTSYDDIGYPLKGTVCYVLSENLQQTTLGATGELCLGGPQVSL
                     GYIGSVQLNEKSFISYDGERLYRTGDLVQQQPDGSIRFIGRKDTQVKIR"
     CDS_motif       complement(2237..2323)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg168_2_0003"
                     /evalue="1.20E-08"
                     /label="NRPS-A_a6"
                     /locus_tag="ctg168_2"
                     /protein_end="365"
                     /protein_start="336"
                     /score="27.3"
                     /tool="antismash"
                     /translation="LGATGELCLGGPQVSLGYIGSVQLNEKSF"
     CDS_motif       complement(2825..2881)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg168_2_0002"
                     /evalue="1.50E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg168_2"
                     /protein_end="169"
                     /protein_start="150"
                     /score="26.8"
                     /tool="antismash"
                     /translation="AYIIYTSGTTGNPKGVRIS"
     CDS_motif       complement(3062..3103)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg168_2_0001"
                     /evalue="3.50E-03"
                     /label="NRPS-A_a2"
                     /locus_tag="ctg168_2"
                     /protein_end="90"
                     /protein_start="76"
                     /score="11.0"
                     /tool="antismash"
                     /translation="LAIFRLGATYLPID"
     CDS             complement(3344..5710)
                     /gene_functions="transport (smcogs)
                     SMCOG1082:TonB-dependent siderophore receptor family
                     (Score: 171.3; E-value: 7.8e-52)"
                     /gene_kind="transport"
                     /locus_tag="ctg168_3"
                     /transl_table=11
                     /translation="MKRCLLYILCCFGVVQLSAQPADNIRNSFVKAETFYKSGDIDEAC
                     RILEENLSSFQGTMHTEACRLAALCCLALDRFPEAEKYVSLLLKDEPYYYISLQDPERF
                     ADMVRKHRETKVTLVTASQQVETPEEAPVPVTLITEEMIRAIHARCLRDVLIAYVPGIS
                     GLSSNEEMNLAMRGVYSPEQENILIMQDGQRLNSYITNAVSPDYGISLAKVKQIEVLRG
                     PASSLYGSVALTAVINIVTKDGVDVRNGSISVSAGNRGQLAADLLLGKHDMNMDFMAWF
                     SLYRATGESVFVPAEKQYALYPRDGFIRLDNYSGFPAMDGGIKLQRGNLLFSFSMNYAK
                     KRQPYSMWLFSSPYSYERFRTFDGSGPGYSRWSAREQAVYSRTWQRITFSTTFYTDWNK
                     NVHYETSGDTLQDYPIFPNYDYQPIIYPTRGAFQYIRWMDFNVGFNGRVNYAYDWGKLG
                     KGNMLGGVEWNRYTLYDSEYLEGMNFKEIVRTWIEKRLYTGHEMNTDAFLQIKHNLHQN
                     WIVNAGIRYDYKRRSNKRTLQAFSPRLSLIYLRNGLNIKASYSRAFVDAPYYYRNNEMD
                     TYSGGENLQAEYLSSYQVTCAYHHSPSHIDVECNLFYNRASHFLFTQPETRVYENAGSL
                     DMGGVEVVARYKADRLSLDGNLCFQKVLNYTNFFVTDGSVNNVPGFSMNLVANYFLLKK
                     KVQSWSAHLKLNCSSHCYTQVSVLEDGLNGDATNYTVRLPGYAVFSFTTRYKYKRIEGS
                     LGIENLFNNRYECGGATVPIRQKGRWISASILYNF"
     CDS             complement(5707..6543)
                     /gene_functions="regulatory (smcogs) SMCOG1003:sensor
                     histidine kinase (Score: 136.3; E-value: 3e-41)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg168_4"
                     /transl_table=11
                     /translation="MEKNISQEKRIEELEARLKEQEKLGSLGLLSAGIAHEIQNPLNFV
                     INFSKLSGQLLADLADRVDEAKARIPEAELEDIKDILSGLRENVDKIKEHGDRAISIIR
                     GILLYSRGKEDEFMPTQIQKLTKEYVWLAYHAMRANYKNFNIAIREDYAKDIPSIRLIP
                     QDFSRAVLNVMNNACYAVWKKWQNAPEGYSPEIMVTLEKLDKRIVLSIRDNGEGMGPEV
                     KRKLFDSFFTTKPVGQGTGLGMAIVRDIIENKHHGKVLFDSVLHEYTCFRFIIPIA"
     CDS             complement(6566..9403)
                     /locus_tag="ctg168_5"
                     /transl_table=11
                     /translation="MKKIVFLIMCLCSVYANSQEGVPFFVNYPASVYQAHNRNFDVVCD
                     SCGNVYFANFEGILHYDYNRWETIYTPGFSRVTRLFRDSEGRIWVGGYNVFGRIERDGR
                     GCITLRTLLSDLDTDSLGELEDMAEIDKRIYLKATSGRYYTVQSDSILTPVQVLPAQLQ
                     EKWRNQSSVSMNRAFSLPGGETISINSAHGLIMDDSGKKERFSVTERNGLCSNAVSGIA
                     ADGRGNLWGATDNGVFHVFIPSLFSRYTSGEGLKGEVISAVSYKGMIYTGTLQGLYVLK
                     QNTFVPVQGISQACWQLCLSPQGELYAASGDGVYVIRDYNHSEKLTDMAAYSLAFIGHT
                     NLLMGTMDGIYQYSADEERIKKISDVEKVVRLEVKKDRSVWAKTLYGEIYLREEGESSF
                     VLQDRESEEVMTEYTDNDGCHWQTNLKGKEVQVHHSQIDTEKFNQCLYAIRNYVVRVIY
                     IEEDRAAWFGGDFGLIRMDLEKARTFTPVAPRIYLREVCLNRDSVYWGGDLPEESGGAD
                     WQINSTVPRLGNDVRSIRFSFATDAPCFTGSNEYRYRLVGYDPEWSSWDSGTVKEYANL
                     SSGTYTFCVRARDIYGTESEMKQFRFSLLPPFYLQWYCLILYTVAFGMLLFLLFKWRMR
                     SLLKEKERLEALVGQRTKQLVQQKNEIEEKSLKLEKALKELGQAQDELVRQEKMATVGK
                     LTQGLIDRILNPLNYINNFSHLTSGLLKDLYQNLESVKELLDEDTYLDSVDVINMMRDN
                     LEKIEEHGSNTTRVLKAMEEILRDRNRQLEKTELIGLCRKDMELLSSYYQKEITAMHIA
                     VRTSLPDNPLFIDGNAEQLGKTIMSLLNNGMYAIAKKYGKKAYPAEIGLALESKDGQAV
                     IRLYDNGVGIEQSILDKIFDPFFTTKTTGEAAGIGLYLSKEIILNHHGQIAVRSEKDEL
                     TEFTITLPLWEEKSV"
     CDS             complement(9400..11001)
                     /locus_tag="ctg168_6"
                     /transl_table=11
                     /translation="MIKLNENIIRWIIAVPCILLTVCLVLYRAYRHSASDRERLALSLE
                     EFRDKEKKSVLIQRVSQQMEEIAYQQKDISEKRRQEAVAQTQKANRMQQQAELARERAL
                     AAQLEAEKAYRMADEQKNLAMERQLQAEQSKRVADTLAFLALGRSLGTLSVTQYRSGNM
                     ELASLLAYTAWWFTKRYDGDVYHPAVFNALSLSCRQDQLWFGHKGAVTGIKLLSGGEEK
                     AKAGRNPLPGLVTVGKYGEMIRWKSENGQTYTSELLLNDPCYDFRDVLLRSDSQKYALS
                     YCGQLISTDSAGIVTRFLPKGEYRQLISIASNLVLAVSTTGIYSFDCINHEIQPCFQPE
                     HSITCVGQMEGYLYVFFKNGTVALLSSDGTFLRFIDSLPENSVVTAFCPLANERYAIGC
                     REGVILICDKNGNIRQKLIGHQAAVTAISRKGNKLFSSSYDCTLRLWDLRKGKTESAVI
                     VTSPGWIHTFCFHPDGTSVFMGDEQGRLYRVPISPDHMAAVVRQGLQRDFTREEWEYYI
                     GKQIPFESYYLKTYQP"
     CDS             complement(10998..11426)
                     /locus_tag="ctg168_7"
                     /transl_table=11
                     /translation="MTLLQFRPVDGRLDEILSMLMHSREVASHPSLSYAIRLVSEEIIV
                     NILNYAYPQQAEGYLTLCLWDEDGEITLEFIDGGIPFNPLDKADPDISLPLEQREIGGL
                     GIFLVREMMDDVAYTYVNKENRLTIKKKYLQPTDEPVS"
     CDS             complement(11441..11746)
                     /locus_tag="ctg168_8"
                     /transl_table=11
                     /translation="MEKYEIHSVGSVLDSNTSGDEQAKIVALIGQGHSVALDLSGCSYV
                     SSAGLRVMLYAFKLAKAKSKDVCLVGVSQEVKDVMHMTGFDKFFRFYQTLDELSQP"
     CDS             complement(11765..12934)
                     /gene_functions="other (smcogs) SMCOG1054:hypothetical
                     protein (Score: 220.1; E-value: 1.1e-66)"
                     /gene_kind="other"
                     /locus_tag="ctg168_9"
                     /transl_table=11
                     /translation="MAVKILSVDDELDLEVLLTQYFRRQIRKGEYEFAFAHNGLEALQK
                     LLETPDFDIILSDINMPEMDGLTLLAKVNELKNPAMKCIMVSAYGDMDNIRSAMNKGAF
                     DFATKPIDLDDLSRTIEKAIEQVRYIRESQQEHNQLESIKNDLAIAGEIQQTILPRSFP
                     PFPELTEVVDIYASMTPAKDVGGDFYDFFQIDDERIGLVIADVSGKGVPASLFMAVSRT
                     LLRATALRGVSSAECLTYANKLLCKESLDSMFVTVFYGIYHYKTGMMDYTNAGHNPPYL
                     LRGGRTVEFLPVASNFVVGVFDDIEFESNTLTFGIGDTLLLYTDGVTEAFNDKREQFSE
                     SNLQDILASMHESSSAKEVVTSVLQSVKTFSGDYPQSDDITLLSLQRIK"
     CDS             13282..13800
                     /locus_tag="ctg168_10"
                     /transl_table=11
                     /translation="MLIILKQDDSCQVAQTTCTTNSLEIRYKDYSVLKKTLDLNTKSIN
                     SDSCIELIIYGTHGNEKEICKLTKPDIKDLTYFFKGKVCRLVLDACHSACHIPHFKEML
                     TDDGIILCHVGICQVNSIETKTGKDTYERWINGNKEGLKVWSDGIVPAIYTQKNNTLTY
                     YECSKFEVDI"
ORIGIN
        1 atgtcaattc atttctctct caggtttatg cagaatagag tttatacggt tctcttcata
       61 aataattaat tgatgcgtag cctctgcaag atctgacttc aggtgataca aataggtacg
      121 cccggttaat ctttcttcca ttatccgttc tagttctttc cgtatatcat cagatggatc
      181 gatttccata acacgcggta tgatggctcc cgaagctgta gactcccctt cctgaccttg
      241 caaataatca tattgggaca aagtatagtc catcagctga tcatagttta gttttttcct
      301 ggaagatatc gtttctgcca aaggaatata gtaaagaata tccttgataa aagagctata
      361 ttcagtctgt acgcggcgta ccagactcat atactttttt tcttcggatg ataaatgcgt
      421 agaagtgaaa gaaaaggatg cggcaaccat ctgatattcg agccctttat tgatttctgt
      481 caacacctct ttggcatatg catagttttt catggatata gacgaaacaa ccgtattcaa
      541 cacatacaaa tcaatagatt tgaggttctc tgccagttct tgtttgaaac cggtaaacca
      601 atcttgttgc tgagtataaa ttatggtatc taactgcagg agtttcaaat cgtgatgaag
      661 tacacctgtc tgctgaagtg tcttgttcag aatcataatc gagatgaccc ctccgatgat
      721 tcctccaata taactgccgc cgaaaccaat ccaggtgggc acatcgtctg cacccgccat
      781 cagagtcaac ggattcagtt cgattaatgc ccaattgatt ggaaaaggca gtacaagaat
      841 caagccaagc aaaataagaa gctctttctt acctaaagtg aagttttcag tctgcataaa
      901 tctacttcaa aaacacagtt attaattgtt ccaatgattc cccttctaaa aagtgccaat
      961 gatctgccgg caatcgcaaa acaggagcgt tcggataata tttattccat aatctttcgc
     1021 aattgtcata ttctgtccgg aatatacgat agttttcctc cgtccacgac tcttcaggag
     1081 acaatcccgc ctgttgatgg aacaatccgg acagcaaaac aataacctct ccctgataaa
     1141 tcagattagg agtggttcga aaataaatat ttatgatttc gttccgttta cgtaccattt
     1201 catcggtatc tccgggaaat accaacaaag gataattttg acagagagcc ggattttgcc
     1261 aagcctgtcc atccagagca aaaacttttg gcattatccc catggagcga tgtaacattt
     1321 cggccaggcc gacagccagt tcagctccca tacagaagcc ggtaagcgca tagacggtac
     1381 gctcccggat cattggctga accgtccgga cataatattc caacagttcc ggaatatccg
     1441 tggccacttt attaaaatga tcgtagatag catctacaac tagaaagtca tatttgggat
     1501 aaaggcggtc ggccaaatta aagtacaaat gattaaaata ggcagatcca caaaccagaa
     1561 tgattacggg tttcttcagg ttttgctgcc tgtaccaata gataggttca tgccgcggaa
     1621 cgagcaataa tcggcgcaga ttacgggcag tataaactgc agatacgttg atgggacatc
     1681 cttttttatt ggcctcggta acaagcctca acatatccag cgaagttaat cccagatcat
     1741 caatcaaatc ggcctcaaca ctgacttgag gcaaacctaa catttccttc aaaattccac
     1801 ataagataac ctcgcccgga tgaacaggag gaacatactt caactccaat gaagtaaaag
     1861 ccgggagcgc ccggacatca atcttatcat ttatagtacg ctgaaaatga tctaccacct
     1921 gccataaatt gggtatcatg tagtaaggaa gttctgcacg caaacgctct ttgacctctt
     1981 ccggatgaaa gttaccggag actgagggtt gcaaataagc tcccaataat tgacgcccat
     2041 tccgctcaac aactactacg tgggctctct ccacgtccgg atctctattc aatcgttctg
     2101 ctatttcagt caattcgata cgaaaaccac gtatcttgac ctgagtatct tttcgcccga
     2161 taaaccgtat tgaaccgtcc ggttgctgct gtaccaggtc acctgtcctg tacaaccgtt
     2221 ctccatcgta cgagatgaat gatttttcat tcagctgaac actcccaata tatcccagcg
     2281 aaacctgagg tcctcccaag caaagttctc ctgtagcccc aagagttgtc tgttggaggt
     2341 tttcagacaa aacataacag acagttccct tgagcggata gccaatatcg tcatacgacg
     2401 tatctttgcc tacaatccgt atggtactga gtacggtatt ctctgtcggt ccatatacat
     2461 tcatcaaccg gtaaggctgc tgcttcagcc tgttaaataa cttttcacca atagcctccg
     2521 caccaaagag cagagtctta aaggatggaa agtcaaggtc ggcaaacatg cccagcaacg
     2581 aaggaggaaa aaaagcaata ttcaccttct cgcgcctgat cagttcgtct agtaaagaaa
     2641 tatctctgcg ttcgtcctca ccggccagga tcaatgttcc tccgaccgga atacacatca
     2701 tcagttctaa tatggaagca tcaaaactga tactcgcaaa cgctagatac ctgtttgccg
     2761 gatcagacaa atgatacaat ttcttatcta ccagattcct cgtaaatgta tccagattcc
     2821 gataactaat acgtacacct ttgggattac ctgttgttcc ggaagtatat ataatatagg
     2881 cgcaatcatt gggaagaact tcagtatagt caccaacaac cggttcggat agttgctccc
     2941 cattcaggta aagttggcgg acggacggaa ttccacctac ttcattcgat gaatcggtca
     3001 acaacaaaac catatccgca ttttcagcca tataccgttt acgattatcc ggcagcgagg
     3061 gatctatcgg taaataagtt gcccctaacc ggaaaatagc cagaatggca ggtactaaag
     3121 ttttgtttcg ttccatacaa actccgatac agatattccg aagtccggac ggatcagtta
     3181 ccgataaacg ttgacggata gattgtgcta tattggcaga gtaacgttcc agcatttgat
     3241 aagagacggt accgtctttt gcaacgaccg ccggtttgtc accccaggta gagagtgatc
     3301 gagaaagatt ttcttgaatg tttgttttca ttattagttt gatttagaaa ttatacaata
     3361 tactggcgga aatccacctt cctttctggc ggataggaac agtcgctcct ccgcattcat
     3421 atcggttatt gaaaagattc tcaatgccca gactgccttc tatcctttta tacttatatc
     3481 tggtagtgaa agaaaagaca gcataaccgg gcaaacggac tgtgtaattc gtcgcatctc
     3541 cattgagtcc atcttccaat acacttacct gagtgtagca gtggctactg caattcaatt
     3601 ttaaatgggc agaccagctc tgtactttct ttttaagtaa aaagtagttt gctacaagat
     3661 tcatagaaaa gccgggtacg ttattcacag atccatcggt aacaaaaaaa ttggtataat
     3721 tcaatacttt ctgaaaacac aggtttccat ccaggctcag tcggtctgcc ttataacggg
     3781 caacaacctc gacacctccc atatccagag aaccggcatt ttcataaaca cgtgtttccg
     3841 gctgtgtgaa caggaaatgg gacgcccgat tataaaataa attacactct acatctatat
     3901 gtgaaggtga atgatgataa gcacaagtca cctgatatga acttagatat tcagcttgca
     3961 gattttcgcc acccgaatag gtatccattt cattgtttct gtaataatag ggcgcatcga
     4021 caaatgctct ggaataactg gctttgatat ttaatccgtt cctgagataa attagtgaca
     4081 gacggggaga aaaagcctgt aatgtccgct tattacttcg ccgtttatag tcatacctga
     4141 tgccggcatt gacaatccaa ttttgatgca ggttgtgttt aatctgaaga aaggcatccg
     4201 tgttcatctc gtgtcccgtg taaagtcgtt tttcgatcca cgtcctgacg atctctttaa
     4261 aattcatacc ttccaaatac tcggaatcat aaagcgtata ccgattccat tccacaccgc
     4321 caagcatatt gcctttcccc agcttccccc aatcataggc atagtttaca cgcccattaa
     4381 agcctacgtt aaaatccatc cagcggatgt attgaaatgc tccgcgagtc ggataaataa
     4441 taggttgata atcatagtta ggaaaaatag gatagtcttg taaagtatct cccgaggttt
     4501 cataatgtac gtttttattc caatcggtat aaaatgtggt actgaaagtg atccgctgcc
     4561 acgtgcggct ataaacagcc tgttctcttg ccgaccacct ggaatatccc gggccggaac
     4621 cgtcaaaagt acgaaaccgc tcataagaat atggagaaga aaagagccac atgctataag
     4681 gttgcctttt cttcgcgtaa ttcatactga aactaaaaag caaatttcca cgttgcaatt
     4741 taattcctcc atccatggca ggaaatcccg aataattgtc cagacggatg aatccgtccc
     4801 tggggtaaag agcatattgt ttttcggccg ggacaaaaac cgattctccc gttgcacggt
     4861 acaaggagaa ccatgccata aagtccatgt tcatgtcgtg ctttcccaat agcaggtcag
     4921 cagccaactg gccccgatta ccggcgctga cagatatgga accattacga acatccaccc
     4981 cgtctttagt aactatatta atcacggctg tcaaagccac actgccataa agcgaagaag
     5041 ccggtccgcg cagcacctct atttgtttga cttttgccag actaatacca taatccggcg
     5101 aaacagcatt agtaatataa ctgttcagac gttgtccatc ctgcataatc aatatgttct
     5161 cctgttcggg agaatatacc ccgcgcatag ccagattcat ctcttcattg gaagacaaac
     5221 cggatatacc gggcacataa gctatcagta catcccgcag gcaccgggca tggatagccc
     5281 gtatcatctc ctccgtaatt aaagtaacag gcaccggagc ttcttccggg gtctctacct
     5341 gttgtgaggc tgtgaccaga gttactttag tctccctgtg tttccttacc atatccgcaa
     5401 agcgttccgg atcttgaagc gagatataat aataaggttc gtctttcaat aacagcgaaa
     5461 catacttttc cgcttccggg aagcggtcta aagctaaaca gcataatgca gccaaacggc
     5521 acgcctcggt atgcatcgta ccttgaaaag acgacagatt ctcctccaag atacgacaag
     5581 cttcatcgat atctccgctc ttataaaatg tttccgcctt tacaaacgaa ttacggatgt
     5641 tatccgccgg ctgagctgac agttgcacaa ccccaaagca gcaaagaata tatagcagac
     5701 agcgtttcat gcgataggaa tgataaaccg gaaacaagta tattcatgca ggaccgaatc
     5761 aaacaatact tttccatggt gtttgttttc tataatatca cgaacgattg ccataccaag
     5821 gcctgtcccc tgccccaccg gttttgttgt gaaaaaagag tcaaatagtt ttcgtttgac
     5881 ctccggaccc atgccctctc cgttatcacg aatagaaagt acaattcttt tatccaactt
     5941 ttctaaggtc accattatct cgggggaata tccttcggga gcattctgcc attttttcca
     6001 tactgcatag caggcattat tcatcacatt caagactgcc cgactgaaat cctgcgggat
     6061 cagccggatc gaggggatat ctttagcata atcttcacgg atagcaatat tgaaattctt
     6121 ataattggcc cgcatggcat gataagccag ccacacatat tctttagtca atttttgtat
     6181 ttgtgtaggc atgaattcgt cttctttccc cctggagtaa agcaaaatac cacggataat
     6241 gctgatagcc cgatcaccat gctctttgat tttgtccaca ttctctctca gcccggaaag
     6301 tatatctttg atatcttcca gttccgcttc cggaatacga gcttttgctt catccaccct
     6361 atcggccagg tcggccaaca attgaccgga cagtttactg aaattgatga caaaattcaa
     6421 aggattctgt atctcgtgtg caatgcctgc actcaacaaa cccaatgatc ccagcttttc
     6481 ctgctctttg agccgtgctt ccaactcttc aattcgtttc tcttgtgaaa tgtttttttc
     6541 cataatcaat ctgttctatg tttatttata ctgacttttc ctcccacaat ggcagagtga
     6601 tagtgaattc tgtcaattca tctttttcag aacgtactgc tatctgccca tggtgattta
     6661 atatgatttc cttactcaga tacaaaccga tacctgctgc ctctccggtt gttttggtag
     6721 taaagaacgg atcgaagatt ttatccagaa tactctgctc gatccccact ccattgtcat
     6781 ataggcgaat gactgcctgt ccgtccttac tttccaatgc caggccaatc tctgccggat
     6841 aggctttctt accgtatttt ttggctatgg catacatacc attgttaaga agactcataa
     6901 tggtttttcc cagttgttcg gcattcccgt caataaacaa cggattatcg ggcaaggaag
     6961 tacgaaccgc aatgtgcata gccgtaatct ccttctgata ataactgctc aatagctcca
     7021 tgtctttccg gcataaaccg attaattctg ttttttccag ttgcctgtta cggtctctca
     7081 ggatttcttc catggccttc agtacacgag tggtgttact tccatgttcc tcaatctttt
     7141 ccagattatc tctcatcatg ttgatgacat ctaccgaatc caagtaggta tcttcatcca
     7201 aaagttcttt tacactctcc agattctgat ataggtcctt cagtaatcct gaggtcaagt
     7261 gggaaaaatt attaatgtaa ttcaacggat tcagaatacg gtcaatcaac ccttgagtca
     7321 gtttacctac agtagccatt ttttcttgtc gaaccaattc atcttgtgcc tggcccagct
     7381 ccttcaatgc tttttccaat tttaaggact tttcctcaat ttcatttttt tgttgtacca
     7441 actgtttggt acgttggccg acaagggcct ctaacctctc cttctctttc agcaaactgc
     7501 gcattctcca tttaaacaat aagaacaaca gcattccaaa agcaacggta tataggatca
     7561 gacaatacca ttgcaaataa aaaggaggca ataacgaaaa gcggaattgt ttcatttcac
     7621 tctctgtgcc gtaaatatca cgggcccgga cacaaaacgt atacgtaccc gacgaaaggt
     7681 tggcatactc tttcacagtc ccggaatccc acgaactcca ttccggatca taaccgacca
     7741 ggcgatatct atactcattg gaaccggtga aacagggcgc atcggtagca aatgaaaaac
     7801 gaatggaacg tacatcattc cccaaacgag gtactgtact atttatctgc cagtccgctc
     7861 ccccggactc ttccggcaaa tctcctcccc aatagacaga atcacggttc agacaaactt
     7921 cacgaagata gatgcgggga gcaaccggag taaatgtccg ggccttttca aggtccatcc
     7981 gaattaaacc aaaatcaccg ccgaaccatg ccgccctgtc ttcttcaata taaatcaccc
     8041 tcacgacata attccgaatg gcatacaggc attggttgaa tttctccgta tcaatttgcg
     8101 aatgatgtac ctgtacctct tttcctttca gatttgtctg ccaatgacag ccatcgttgt
     8161 ccgtatactc ggtcattact tcttcactct ctctgtcttg aagtacaaaa gagctttcgc
     8221 cctcttcccg caaatagatt tctccgtaca acgttttagc ccatacagaa cgatctttct
     8281 tcacttccag acgaacgact ttttcgacat cggaaatttt ctttatccgt tcctcatctg
     8341 ccgaatattg ataaatccca tccatagtgc ccatcagaag gttcgtatgc ccaatgaatg
     8401 ccaatgaata agctgccata tctgtgagtt tttccgaatg attataatcc cggatcacat
     8461 acacaccatc gccggacgct gcatataatt ctccttgtgg agaaagacac agttgccaac
     8521 atgcttgcga aattccctga acaggaacaa aagtgttttg cttcaatacg tataatccct
     8581 gtaaggtccc ggtatatatc attcctttgt aagagacagc cgatattacc tctcccttca
     8641 gaccttcacc agaggtataa cggctgaaca aagagggaat aaaaacatga aacacaccgt
     8701 tatccgtagc tccccagaga ttgccacgcc catcggccgc aatacccgaa acagcgttac
     8761 tgcataagcc atttctctca gttacggaaa accgttcttt tttcccactg tcatccatta
     8821 ttaatccatg ggcagagttt atcgagattg tttctcctcc gggtagagaa aacgcccgat
     8881 tcattgagac tgaggattga tttctccact tttcctgcaa ttgggccgga agtacctgaa
     8941 ccggtgtcaa aatggaatct gactgaaccg tataatatct tcctgatgta gctttcagat
     9001 aaatgcgttt atctatttct gccatatctt ccaattcgcc caaagagtct gtgtccagat
     9061 cggaaagaag ggttctcaac gtaatacatc cgcgtccatc acgctctatc cgtccgaaca
     9121 cgttatatcc tcccacccat atcctacctt ccgaatcacg aaacaaacgg gtgacacggg
     9181 aaaagcccgg tgtataaata gtttcccaac ggttatagtc ataatgaagg ataccttcga
     9241 aattagcaaa atagacattt ccacaactgt cgcaaacgac atcgaaatta cgattatgcg
     9301 cctgataaac cgaagccgga tagtttacaa aaaacgggac accctcttgt gaatttgcat
     9361 ataccgagca aagacacatt atcaaaaaga ctatcttttt catggctgat acgtttttag
     9421 gtaataggat tcaaatggaa tttgcttacc gatataatac tcccattctt ctcgagtaaa
     9481 atcacgctgt aacccctgac ggacaacagc agccatgtga tcgggtgaaa taggcacccg
     9541 atacaaccgc ccctgttcgt ctcccataaa gacagatgta ccgtccggat gaaagcaaaa
     9601 agtatgaatc caaccggggc ttgtcacaat aacagccgac tcggtctttc ctttacgaag
     9661 atcccacaga cgcagcgtac aatcgtaact actcgaaaac agtttgttcc ctttccggga
     9721 aatagcagta accgcagcct gatgccctat caacttctgc cggatatttc cattcttatc
     9781 acaaatcagg ataactcctt cacgacagcc aatggcatat ctttcattgg caagaggaca
     9841 gaatgcagta accacactat tctcgggcaa gctgtctata aatctgagaa atgtaccatc
     9901 cgacgaaagt aaagctactg tcccattctt aaaaaaaaca tagagatagc cttccatttg
     9961 accgacacaa gttatcgaat gttccggttg aaaacaaggt tgtatctcat ggttgataca
    10021 gtcaaaagaa taaataccgg ttgtggaaac cgccaatacc aagttagagg caatcgaaat
    10081 caattgccga tattctcctt taggcaaaaa gcgggtaacg ataccggcgg aatccgtgga
    10141 gataagctgc ccgcagtatg acaaggcata cttctgtgaa tcggaccgca acagcacatc
    10201 ccgaaaatca taacagggat cattcaacag taattcggag gtataggtct gcccattttc
    10261 cgatttccaa cgtatcatct caccgtactt gccgacagtg accaatcccg gcagaggatt
    10321 ccgaccggct tttgcttttt cctcgcctcc ggataacagt ttgatcccgg taacagctcc
    10381 tttatgcccg aaccaaagct gatcttgcct gcaagacaaa gacaatgcat tgaaaacagc
    10441 cggatgatat acatcgccat catatcgctt ggtaaaccac caggcggtat atgccaacag
    10501 agaagctaat tccatgttgc ccgaccgata ttgagtaaca gagagtgtcc ccaatgaacg
    10561 tcccaaagcc agaaaagcca atgtatcggc aaccctcttc gactgttcgg cctgtagttg
    10621 ccgttccatc gccagattct tttgttcatc tgccatccga tacgctttct cagcctccaa
    10681 ttgtgcagca agcgctcttt cccgtgccaa ctctgcctgc tgttgcattc ggttggcctt
    10741 ttgagtttgc gcaacggctt cctgtcttct cttttcggaa atatcctttt gttgataagc
    10801 aatctcctcc atttgttgac tgacccgttg tataagaacc gatttctttt ctttatcccg
    10861 gaattcctcc agagacagag caaggcgctc cctgtccgat gccgaatgac gatatgcccg
    10921 gtataggacc agacatactg tcaaaagtat acaaggaacg gcaatgatcc aacggatgat
    10981 attttcgttt aacttgatca tgatacaggt tcatcagtgg gttgcagata tttcttttta
    11041 atggtcaacc gattctcctt attcacgtac gtatacgcta cgtcatccat catttcacgt
    11101 accaggaaaa tgcccaatcc tcctatttca cgctgttcta acggtaatga aatatcagga
    11161 tcggctttat ccaaaggatt gaatggaata ccaccatcta taaactccaa agtaatctct
    11221 ccgtcttcat cccataagca cagagtcaga taaccttctg cctgctgcgg ataagcgtaa
    11281 ttgagaatat tgacaatgat ctcctcactg accaaacgga tggcataaga cagggaagga
    11341 tgtgaagcaa cttcacgact atgcatcagc atactaagaa tttcatctaa cctcccatcg
    11401 acagggcgaa actgaagtaa cgtcattgct caggtaattt ttagggttgt gataattcat
    11461 cgagagtctg ataaaaacga aagaatttat cgaatccggt catgtgcatc acgtctttaa
    11521 cctcttgtga cacaccgaca aggcaaacat ccttactttt agctttcgcc agcttaaaag
    11581 cataaagcat gactctcaat ccggcactgg atacataaga acagccgctg agatctaatg
    11641 caacagaatg tccttgcccg ataagagcta caatttttgc ttgttcgtca ccgcttgtat
    11701 ttgaatccaa gacggaacct acagaatgaa tttcatactt ttccatcgtt cttttatttt
    11761 aatattattt gattcgttga agagaaagca gggttatgtc atcggactga ggatagtctc
    11821 cggagaaagt cttaacagac tgcaatacac tcgtaacaac ctcttttgcg gaactacttt
    11881 cgtgcataga cgccaatata tcctgtaagt tactttccga gaattgttcc cgcttgtcgt
    11941 taaaagcctc tgtgacacca tccgtataca gaagtaaagt gtcaccgatg ccgaacgtca
    12001 atgtattact ctcaaattca atatcatcga atacgcctac cacaaaatta gaagcgacag
    12061 gcaagaattc aacagtccgt ccgccacgaa ggagataagg gggattatgc ccggcattgg
    12121 tatagtccat catgccggtt ttataatgat aaatcccata aaagaccgta acaaacatag
    12181 agtccaggct ctctttacac agtaacttat tggcataagt aaggcattct gctgacgaaa
    12241 caccccgaag agcagttgca cggagcaggg tccgactaac cgccatgaac aaggatgccg
    12301 gcaccccttt cccggatacg tcagcaatca ccagcccgat acgttcatcg tcaatctgga
    12361 agaaatcata aaaatcgcca cctacatctt ttgccggagt catggaagca taaatatcaa
    12421 ccacttccgt cagttccgga aaaggaggaa aggaacgggg aagaatcgtt tgctggattt
    12481 ctcccgcaat ggccaggtca tttttgatag attccagttg gttgtgctcc tgctgtgact
    12541 cacggatata gcgaacctgt tcgatcgcct tttcaatagt ccgcgacaga tcatccaaat
    12601 cgatcggttt ggttgcaaaa tcaaacgctc ccttgttcat agcagaacgt atgttatcca
    12661 tgtctccata agcagagacc attatacact tcattgccgg atttttcagt tcattgacct
    12721 tagccaatag ggtcaaccca tccatctccg gcatattaat atcactcagg atgatatcga
    12781 aatcgggagt ttccagaagt ttctgtaaag cttccaaccc gttatgggca aaagcgaact
    12841 cgtattcacc ttttcgtatt tgtcgcctga agtactgggt aagtaatact tctaaatcaa
    12901 gttcatcatc tacactcaat atttttactg ccatatctat tgttatttat gaatttcaac
    12961 cgtttgttct gacgtttatg atggcaaaaa tagagagtga ccgccccggt tacaatttta
    13021 tattttaaac aggaagaatg tttttccgaa tggacgatat tgtcttataa gcatacaggt
    13081 atattgcttt cgtggcttag aagacagcac ctgaaagatt gatttacact cctgaaagaa
    13141 actattccgt attcagaatt tatattttta agatggaact tttcttctca cttttgtcac
    13201 cgtaagctta caaagaataa atagaaacgg cggattccga aaagccgaag aaagagtagg
    13261 aactttttac gaatcactat tatgcttatt attttaaaac aagatgatag ttgtcaagtt
    13321 gcacaaacga catgtacaac aaactcttta gaaatccgat acaaagatta tagtgtactg
    13381 aaaaaaactc tggatttgaa cacaaaatct attaatagcg atagctgtat agagttaatt
    13441 atttacggaa cacacggaaa tgaaaaggaa atttgcaaac taaccaaacc agacataaaa
    13501 gatctgacct atttcttcaa aggaaaagtt tgtagattag ttcttgatgc ttgccatagc
    13561 gcctgccata ttccacattt caaagagatg ttaacagatg atggaatcat attatgtcat
    13621 gtaggtatct gccaagtaaa cagcatcgaa actaaaacag gtaaagacac ctatgaacgg
    13681 tggataaatg gcaataagga aggattaaaa gtatggtcgg atggaatcgt tccagctatc
    13741 tatactcaaa agaataacac tttaacttac tacgaatgta gcaaattcga agtagatatt
//
