LOCUS       c00245_gnlPro..        13825 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|FPBICPHB_276.
ACCESSION   c00245_gnlPro..
VERSION     c00245_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 20:57:34
            Original ID  :: gnl|Prokka|FPBICPHB_276
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13825
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13825
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[366:3825]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      367..3825
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..13825
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13825
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             2..136
                     /locus_tag="ctg245_1"
                     /transl_table=11
                     /translation="SYLQSIINDVHLTCFLLNSCTEKRIRGNLGKRPIKYKHDNDSKS"
     CDS             367..1059
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: SucD_FumR"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg245_2"
                     /sec_met_domain="SucD_FumR (E-value: 6.3e-121, bitscore:
                     392.4, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MWLSNSSVGRKVVMSVTGIALVLFLTFHMAMNLVAIISAEGYNLV
                     CEFLGANWYALVATLGLAALFVIHIIYAFWLTIQNRAARGSERYAVVDKPKTVEWASQN
                     MLVLGIIVILGLGLHLFNFWAKMQLPELVHNMGGVADTTYAADGVYHIMNTFSNPVYVV
                     LYLVWLGALWFHLTHGFWSSMQSLGWNNKIWINRWKCISNIYSTIVVVCFALVVVVFFV
                     KSLACGAC"
     CDS             1097..3040
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 197.1; E-value:
                     1.8e-60)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg245_3"
                     /sec_met_domain="FAD_binding_2 (E-value: 9.9e-61, bitscore:
                     197.1, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 5.4e-38,
                     bitscore: 121.1, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKIDSKIPEGQLAEKWSNYKAHQKLVNPANKRRLDIIVVGTGLA
                     GASAAASLGEMGFRVFNFCIQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRLFYDTIKG
                     GDYRAREANVYRLAEVSNAIIDQCVAQGVPFARDYGGTLDNRSFGGAQVSRTFYARGQT
                     GQQLLLGAYSALSRQVQKGTVKLYTRYEMLDLVVIEGRARGIIARNLVTGEIERFAAHA
                     VVIGTGGYGNAFFLSTNAMGSNGSVAIQCYKKGAYFANPCFAQIHPTCIPVHGDKQSKL
                     TLMSESLRNDGRIWVPKKIEDAKALQAGTKKPTEIPDEDRDFYLERRYPAFGNLVPRDV
                     ASRAAKERCDAGFGVNNTGLAVFLDFKYAIDRLGEDVVRARYGNLFDMYEEITDENPYK
                     TPMMIFPAIHYTMGGIWVDYELMTSIPGLFAIGEANFSDHGANRLGASALMQGLADGYF
                     VLPYTIQNYLADQIQVPRFSTDLPEFAAAEKEVKDKIQKIKAVNGKHSVDSIHKKLGHI
                     MWDFVGMARTKESLQKALTGIEEVKKDFWTNVRIPGDVNELNVELEKALRLIDFIEVGM
                     LMARDGLNREESCGGHFRTEYQTPEGEALRDDKNFSYVACWKYTGENSEPELIKEDLNY
                     QFVKVQTRNYKS"
     CDS             3070..3825
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer4_7"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer2_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg245_4"
                     /sec_met_domain="Fer4_7 (E-value: 3.3e-12, bitscore: 38.1,
                     seeds: 208, tool: rule-based-clusters)"
                     /sec_met_domain="Fer2_3 (E-value: 4.3e-26, bitscore: 82.3,
                     seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 1.3e-06, bitscore: 20.0,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKNISFTLKVWRQKGPKAKGAFETYQMKDIPGDTSFLEMLDILN
                     EQIINDGGEPIVFDHDCREGICGMCSLYINGHPHGPATGATTCQMYMRRFKDGDTITVE
                     PWRSAGFPVIRDLMVDRSAYDKIMQAGGYVSVNTGAPQDANAILISKDIADEAMDAAAC
                     IGCGACVAACKNGSAMLFVSAKVSQLNLLPQGKVEAARRAKAMLSKMDELGFGNCTNTR
                     ACEAECPKNISISNIARLNRDFIIAKLKD"
     CDS             complement(3906..4514)
                     /locus_tag="ctg245_5"
                     /transl_table=11
                     /translation="VQRLTLKRPFTFSRLNFDLHNVAGFYAALVLAVLCFTGLIFSLNW
                     FSRGVYSITSGGEELKPYVLPVSDTLQVVNRVTNPLDRLYTQLRLEEPAAKTFYFAFPG
                     QADGVYRVSVVHKRGSYYRTDNLFFDRYTLVSLKGAGPYAGKYTEASPADKFRRMNLEI
                     HDGRIWGLPGKIIMFLASLTGASLPVTGFIIWYRKRCKR"
     CDS             complement(5043..6263)
                     /locus_tag="ctg245_6"
                     /transl_table=11
                     /translation="MITMYRIYMYLLAACLLLGVTACEEEGLGNEETPFAPYVLSLGIN
                     SNGTTTYYVVTAPELMSGTINAVAKGIEQNGYRDYEQAGQTVFSIGGLGLTSATGIVRD
                     ANGYLTERGDFVFNSSLNAFTQMDGQNMIGLELPANKESGDQMTLYTVNISDVSITSQV
                     KAPVFPLNQLEWPSITGMCYSEGNVYVTYFPMNPSTFETLYTDTTFVAVYSYPDMQFKI
                     LMKDTRTGPAGSWNAFNGIFKVESGDMYIMSNSAIANGFSQSTKNAAFLRIPKGETHFD
                     DYYFDFETVSGGLKPAHIKYIGNGLVFAEVSTISPQTSADRWGDKSLKCCIIDLNNKTV
                     RDIKEIPVHNGDGGRRFAALVDGGYVYRPVTTSEGTYIYQVDPQAATAVRGAKVSTTFV
                     GGFFRLD"
     CDS             complement(6273..8690)
                     /locus_tag="ctg245_7"
                     /transl_table=11
                     /translation="MNHKVLYRVALFCLFSMLSAVLMHAGEQQQQSKGIVTGRIVDQQK
                     QPYYPVAVAIEGVYIGGYTNENGVYHINDVPAGSQTIVVSGIGVKTKKVPIHVTAGKVN
                     RIPDIEIDTQAEELEEVQVIGKSEARRQQEQAYAISVLDIKKAYNSAAPLNKLLNNVSS
                     VRIREEGGMGSNYNFSLNGFSGNQVKFFLDGIPMDNFGSSFNLANISANMAERVEVYKG
                     VLPVNLGADALGGAVNIVSRRDANYLDATYSFGSFNTHKVSVNGAYTHLKTGFTVRANA
                     FYNYSDNDYKVFVPIIDLATNKKIDERWVKRFNDAYRSGGIRLETGITNKPYADYLLAG
                     IILSKNDKDVQTGATMDAVYGGVKMKSESVIPSIRYKKDDLFLDGLSLSLYGTYNSVNT
                     FNVDPIARRYNWLGESVPSTSAGEGYYTDSKIKNREWLGNGNISYVIDGHQSLILNHVV
                     SAMRRTMNDKVRPDDENNNVPQQLTKNITGLGWQIRYDRWNANVFGKMYKLYSSTYKRL
                     DEYTENARWEKVRDHKTNFGYGAAATYYILPSLQAKFSYEHAYRLPESIEMFGDGLIQQ
                     RNPDLKPESSRNLNLGLSFIQTFGAHQLSADGNFIYRYTTDFILKGVSLTSNPTTGYEN
                     LGKVLTKGVEAAVRYNYKDLFHTGAGFTYQDITDRQRYEKTKDSFVGEGITENITYKER
                     LPNIPYLFANADAGVRFHDLIWRNSVLTFDYNLNYIHSYYLSFPGLGAKSSKKVIPEQF
                     SHDLALGYSMDNGKYSVVVECTNLTNQKLYDNYRLQKPGRAFNVKLRYFFSK"
     CDS             complement(8690..8827)
                     /locus_tag="ctg245_8"
                     /transl_table=11
                     /translation="MRQASGREIFFIIVFRYRSFGEYLNMVIVVRCRYTYLCGLIKQSD
                     "
     CDS             complement(8824..9834)
                     /locus_tag="ctg245_9"
                     /transl_table=11
                     /translation="MQQKTKSKLPNNHIPRDVIDSPAFSQGYFFIPSFIVFLNNSLTFV
                     VNIQTNTPVYMPSSVCGDPMMCQNCKKSVPNAIFHVYHRRGFHYPAQKCEENFILFLIK
                     GEMLVNSREYAGTMLKAGEFMLQPISSKIEMLAMTDVECIYYQFNQPELFCDIRYNRIM
                     KETDPPLIPSPLPIIPELQHFLESARTYLSEKKICRDLLSLKRKELAFILGYFYSDYDL
                     ASLVHPLSKYASSFECFVYQNYKKVKTVEEFAKLGGYSQTTFRRIFDNVFHEPVYEWML
                     SRRKEEIIYELQNTEATISEICYKFGFESLPHFSNFCKKSFGTSPRSIRLKRSSE"
     CDS             complement(9800..10813)
                     /locus_tag="ctg245_10"
                     /transl_table=11
                     /translation="MKKILFAAVAALAITGCSQNEEIEKAAKTAEIGFNAIVKNTTRAA
                     VTNMGNLGNFKVHSYITGTAFDGTTAELGTAYMNGVLFETIDNTTWTKATSDTKTYYWP
                     SDASKSVQFFAYPSTLISDFSIPDTGTAGYPSFNYTVDKEADEPGDLVVAYESNKTATS
                     EGVNAGKLTLNFKHILSRINFAYIPGNTNLTYTVTAVKIADIKGGTAKYTFSASNGAWD
                     VTSGTSKEYTYTVTQSPNVVENKSYYMLGGEDASLMLFPQDVAKKVITVTYTSKDDDGV
                     QVFSGDKTVTLPDNSKWEVGKNILYILTLPAGGTEMTVTPKVSEWNAAEDKEQTAQ"
     CDS             complement(10865..11779)
                     /locus_tag="ctg245_11"
                     /transl_table=11
                     /translation="MVLLSFLVVTGCSRRDILDDYPVSGVEVRLDWSGVTEKLPEGVRI
                     IFYPKGDNGRKVDTYLPVKGGHVGVPPGIYSVVVYNYDTETVLVRGDESYETIETYTGL
                     CNFGIAGTEKMVWGPEDFYTTCVDELMVEKSDESLILKLSPKLVVKTYHFSIKVTGIKN
                     ISQVFGSVVGMADHYLLGKSFSLCDGCPIYFDVVRGKDTIEGSFTTFGISQIVRTRAEN
                     TEVSLNLLLLKVDDTVQEVKVDVTEVIHKSEAGGETDKPEIDVPIEDEIKVDDVETPPD
                     GNGGMNGDVDDWEDETDIVIPVE"
     CDS             complement(11813..12784)
                     /locus_tag="ctg245_12"
                     /transl_table=11
                     /translation="MENRICILTLFVFLFLLSGESRAMVAMPDAWTRMMIGVNQKDWSL
                     LRERVQADLHVPDREDVLMLIDYHRDDRMKCENLLRRLNGGEAYRYIMNKILPLLYVYR
                     EHSPVPIPDDKAAGVFLSTANVLPRVKFVHPQPVVPEEGKIETPVIIEQRTVLALKNNL
                     LYDLALAPNIEVEIPLNRRWSVNAEYKCPWWLNSSREFCYQLLSGGVEGRCWLGNRKRR
                     NRLAGHFIGAYAEGGIYDFQFKGDGYQGRYYAASGLTYGYAKQIARHLSFEFSLGIGYL
                     TTEYKKYTPYEGDLVWKSSARYNFIGPTKAKVSLVWLITARR"
ORIGIN
        1 ctcttattta caaagtatta taaatgatgt ccatttgact tgttttcttc ttaattcatg
       61 cacagaaaag agaattagag gaaacctcgg aaaacgacca attaaatata agcatgataa
      121 cgactccaaa agctaacttc ttaaagacaa agattttact attctaacag attcacgaca
      181 aatcctttat acccccaacc gatcgtcccg tttaccccat cctctccgga cattcaggat
      241 taaagaatta tttctttaat tctttggtta atcaatgtat ttcgtgtact tttgcacaat
      301 gagaaagaag gctcgtaaaa cagaaattat agttctaaca attaaataat ttaaaatcaa
      361 tcatttatgt ggttaagtaa ttcatctgta ggaaggaaag tggtgatgag cgttaccggt
      421 atcgcccttg tcctgtttct aacgtttcac atggcgatga accttgttgc gatcatctcg
      481 gctgagggtt acaacttggt ttgtgagttc ctgggagcaa actggtatgc gttggtagct
      541 acgctgggcc tggctgccct cttcgtgatt cacattatct acgctttctg gctgacaata
      601 cagaatcgcg cagcacgtgg tagcgaacgt tacgccgtag ttgacaaacc taaaaccgtg
      661 gaatgggcat cacaaaacat gctggtgctg ggtatcatcg ttatcttagg tttgggcctt
      721 cacctcttta acttctgggc taaaatgcag ttacctgaat tggtgcacaa catgggagga
      781 gtagcagaca caacttatgc tgctgatggt gtttatcaca tcatgaacac tttctctaac
      841 cctgtatatg tagtgctgta cctcgtttgg ctgggcgccc tttggttcca cctgactcat
      901 ggtttctgga gctctatgca atctttgggc tggaacaaca agatttggat caaccgctgg
      961 aaatgcatct ccaacatcta ttcaaccatc gttgttgtat gctttgctct ggtagtagtc
     1021 gtattcttcg ttaaatcgtt ggcatgcggt gcttgctaaa ttgtaaattg taaatgatta
     1081 aattgtaaat agcattatga ctaagataga ttcaaaaatt cctgaaggcc agctcgccga
     1141 aaaatggagt aactataagg ctcatcaaaa acttgttaac cctgccaaca aacgtcgcct
     1201 tgacattatc gttgtaggta ccggacttgc cggagcatct gctgccgctt ctctaggcga
     1261 aatgggtttc agagtattca atttctgtat tcaggattca ccccgccgtg ctcactctat
     1321 tgcagcacag ggtggtatca acgcagctaa aaactatcaa aatgatggtg actcggttta
     1381 ccgtcttttc tacgatacaa tcaaaggcgg tgactaccgt gcacgcgaag ccaacgttta
     1441 ccgtctggct gaggtatcaa acgctatcat cgaccaatgc gtagcacagg gtgtaccttt
     1501 cgcacgcgat tacggtggca cacttgacaa ccgttcattc ggtggtgcac aggtatcccg
     1561 tacgttctat gcccgcggcc agaccggaca gcagctgttg ctgggcgctt attcagcatt
     1621 gagccgtcag gtacaaaaag gtactgttaa actttacact cgttacgaaa tgctcgacct
     1681 cgttgtaatt gaaggacgtg cgcgcggtat cattgcccgt aacctcgtaa ctggtgaaat
     1741 cgaacgtttc gctgctcacg ctgtagttat cggtacaggt ggttacggaa acgcattctt
     1801 cctttctacc aacgctatgg gttccaacgg ttcagttgcc atccagtgct ataagaaagg
     1861 tgcttatttt gccaatcctt gtttcgctca gattcacccg acttgtatcc ccgtacacgg
     1921 tgacaaacag tctaagctga cattgatgtc tgaatcactt cgtaacgacg gtcgcatctg
     1981 ggttccgaag aagattgaag atgccaaagc attgcaggca ggcactaaaa agccgaccga
     2041 aattcctgat gaagaccgtg acttctatct ggaacgccgt taccccgcat ttggtaacct
     2101 tgttccccgt gacgtagctt cacgtgctgc caaagaacgc tgtgacgcag gttttggtgt
     2161 caacaatacc ggtttggccg tattccttga tttcaaatat gccatcgatc gtctgggtga
     2221 agatgtagtt cgcgcccgtt atggtaacct cttcgacatg tacgaagaaa tcactgacga
     2281 gaacccgtac aagactccga tgatgatatt ccctgctatc cactatacaa tgggtggtat
     2341 ctgggttgac tatgaattga tgacctctat cccgggtctg ttcgctattg gcgaagctaa
     2401 cttctctgac cacggtgcca accgtctggg tgcatctgca ttgatgcaag gtctggctga
     2461 cggatatttc gtattgcctt atactatcca gaactatctg gccgaccaga ttcaggtacc
     2521 acgtttctct acagacctgc ccgaatttgc ggcagcagag aaagaagtga aagataaaat
     2581 ccagaagatt aaagctgtaa acggaaaaca ttctgttgac tcaatccaca agaaactggg
     2641 tcacattatg tgggacttcg taggtatggc tcgtactaaa gaatctctgc agaaagccct
     2701 gacaggcatt gaagaggtga agaaagattt ctggaccaac gttcgcatcc cgggtgatgt
     2761 aaacgaactg aacgtagaac tggaaaaagc acttcgtctg atcgacttca ttgaagtagg
     2821 catgttgatg gctcgcgacg gtttgaaccg tgaagaatct tgcggtggac acttccgtac
     2881 cgaataccag accccggaag gtgaagcgtt acgtgacgat aagaacttct catacgtagc
     2941 ttgctggaaa tacaccggtg aaaattcaga accggagttg atcaaagaag atttgaacta
     3001 ccagttcgta aaagttcaga ctcgtaacta caagtcataa ttcggctaat caattaaagg
     3061 aaaacaaaaa tggataaaaa tatatcattc acactgaagg tatggcgcca gaaaggcccg
     3121 aaagcaaaag gtgcttttga aacatatcaa atgaaagata tcccgggcga tacgtcgttc
     3181 ctcgaaatgc tggatatcct gaacgaacag attattaatg acggtggcga acctatcgta
     3241 ttcgaccatg actgccgcga aggtatctgc ggtatgtgtt ctctttacat caacggacac
     3301 ccgcacggac ctgcgacagg tgctactacc tgccagatgt atatgcgtcg cttcaaagat
     3361 ggagacacca tcacagttga accttggcgt tctgccggtt tcccggtaat ccgtgacttg
     3421 atggttgacc gttcggctta tgacaagatc atgcaggccg gtggttacgt aagcgtaaac
     3481 acaggtgctc ctcaggatgc caacgctatc cttatctcta aggatatcgc cgacgaggct
     3541 atggatgccg ctgcatgtat cggttgcggt gcttgtgtag ctgcttgtaa gaatggttct
     3601 gccatgttgt tcgtatcagc taaggtcagc cagctgaacc tccttccaca aggaaaagta
     3661 gaagcagcac gccgtgcaaa agctatgctt tctaagatgg acgaactggg attcggtaac
     3721 tgtacaaaca cacgtgcttg tgaagcagag tgtccgaaga acatttcaat cagcaacatc
     3781 gctcgtttga accgcgattt catcatcgca aaactgaaag actaagcaca acttagcatt
     3841 tgattaataa gtaggaaaat tccccaccgg tatcggtggg gaatttttgt atatggagag
     3901 cagtgttatc tcttacagcg cttacgatac caaatgataa agccggtcac aggaagtgaa
     3961 gcacccgtca ggctcgcaag gaacattata attttaccgg gaagccccca gatgcgcccg
     4021 tcatgaatct ccagattcat acgacggaac ttatcggcgg gagaggcctc ggtatattta
     4081 ccggcataag gaccggctcc tttcaaagaa accagtgtat accggtcaaa aaacaaatta
     4141 tcagtacggt agtaagaccc tcttttatgt acaacactga cccggtaaac accatcggct
     4201 tgtccgggga aagcaaaata aaaggtcttg gcagcaggtt cttcaagccg tagctgagta
     4261 taaagtctgt ccaaagggtt tgtcacacga ttgacaacct gcaatgtatc ggataccggt
     4321 aaaacgtagg gcttcaactc ttcaccaccc gaagtgatgc tgtacacgcc tctgctaaac
     4381 caattcaggc taaatatcaa tccggtaaaa cataatacgg ccagcaccaa tgcagcataa
     4441 aaacccgcaa cattatgcag gtcgaagtta agccttgaaa aggtaaaggg gcgtttcaga
     4501 gtcaaccgtt gcacaagtgc cttgcgtgtc cagcttctgg gccaccaaag tatcactccc
     4561 gttatcaggg tgatgaggaa aatcaataca ctgtaaccaa caatcggact cccgatctcc
     4621 ctggggagcc ataaagtgcg atgcccgcta agcaccaacc ggaagaaatc gaaatcaccg
     4681 ttatgattca ctaccgactt caatacctgt ccgctatacg gattgataaa aacagtactc
     4741 atccctgctt ccggctgata gtagtccacc caggccgcat ccgatctttc accgtaagtg
     4801 atggctgtgg ccgaagctcc tcccatgaca gaatccgcta tcgcaagtaa gcgggaaggc
     4861 ggcaaaaact ctttctccaa tggagctaca aagcgccaag gttgtgtggc atcggtaatt
     4921 tcgtctttaa atgcatacat gcagccggtg atgcagacta tgaataccac aatacccgaa
     4981 aacaatccaa gccataaatg aagtttcgca caagccttcc gaaaagtctt attcatctcc
     5041 tatcaatcca gacggaagaa accgccgaca aacgtggttg aaactttagc tcccctgacc
     5101 gcagtagccg cctgaggatc tacctgataa atgtaagtac cctctgaagt agtgaccgga
     5161 cgataaacat aacctccgtc taccagagcg gcaaaacgcc gtccgccatc tccgttatgc
     5221 accggaatct ctttaatgtc acgtaccgtt ttattattaa gatcgataat gcagcatttc
     5281 aaactcttat ctccccaacg gtcggcggat gtctgcggac tgatggtgct gacctcggca
     5341 aataccagac cattaccgat atatttgata tgggcaggtt tcaatcctcc cgaaaccgtc
     5401 tcaaagtcaa aatagtagtc atcaaaatgc gtctcacctt tagggatacg aaggaaagca
     5461 gcattcttgg tactttgtga gaacccgttg gcaatggcag aattagacat gatgtacata
     5521 tcgccggact ctaccttaaa aataccgtta aatgcattcc acgaaccggc aggaccggta
     5581 cgcgtatctt tcatcaatat cttaaactgc atatccggat aagagtatac cgcaacaaaa
     5641 gtagtatcgg tatataaagt ctcaaaagtg gaagggttca tcggaaaata agtaacgtac
     5701 acattacctt cactataaca catacccgtg atactcggcc attcgagttg attcagcgga
     5761 aataccggag ctttgacctg agaagtgata gaaacatcac tgatatttac ggtatataag
     5821 gtcatttggt ccccactctc cttattagcc ggaagttcaa ggccgatcat gttctgcccg
     5881 tccatttgtg taaacgcatt cagcgaactg ttaaagacaa agtctccacg ctccgtcaga
     5941 tagccgtttg catcacgtac aattccggtt gcactggtca gtcccagtcc gccaatactg
     6001 aacaccgttt gtccggcctg ttcataatca cgatatccgt tttgctcgat acctttggcc
     6061 accgcattga ttgttccgga catcaattcg ggggcagtaa ccacataata agtggtagtc
     6121 ccattggaat tgatacccag gctgagtaca tagggagcaa aaggagtttc ctcatttccc
     6181 aatccttctt cttcacatgc cgtgacaccc aataaaaggc aggcagcaag gagatacata
     6241 taaattcgat acattgtaat catcagactt ttttatttac taaagaaata tctcagtttc
     6301 acattaaagg cacgcccggg tttctgcaag cggtagttat catacagctt ttgattggtc
     6361 agattggtac actccacaac cacactatac tttccgttgt ccattgaata ccccaatgcc
     6421 agatcgtgtg agaactgttc ggggattact tttttagagc tttttgcacc caagcccggg
     6481 aacgaaagat aatacgaatg aatataatta agattatagt caaacgtcag cacagagttt
     6541 ctccaaatca aatcgtgaaa acgaacccct gcatcggcat tagcaaacaa ataagggatg
     6601 ttcggcaaac gctctttata ggtaatattc tctgtgatac cttcgccgac aaagctgtcc
     6661 ttcgtcttct catatcgctg ccggtcggta atgtcctgat aagtaaaacc ggctcccgta
     6721 tggaacagat ctttatagtt atatctgaca gcagcctcaa caccctttgt caacacctta
     6781 cccagattct cgtaaccggt ggtcggatta ctggtcaggc tgaccccttt caggataaag
     6841 tctgtcgtat aacgataaat gaagtttcca tcagccgaaa gttgatgggc tccgaaagtt
     6901 tgaatgaagc tcaaccccag attcaaattc cggctgcttt ccggttttaa atccggattc
     6961 cgctgctgaa tcaacccgtc tccaaacatt tcgatacttt ccggcaaacg ataggcatgc
     7021 tcgtaagaga acttagcctg caaagagggt aagatataat aagtagccgc cgcaccgtat
     7081 ccgaaattgg ttttatgatc ccgcactttt tcccaacggg cattctctgt atattcatcc
     7141 aaccgcttat aggtagaact gtacaactta tacatctttc cgaatacatt ggcattccaa
     7201 cgatcatagc ggatctgcca tcccaagcct gtgatattct tagtcagttg ctgaggtaca
     7261 ttgttgtttt catcatccgg ccgtacttta tcattcatgg ttctccgcat agcagaaacc
     7321 acatggttca gtatcaatga ttggtgaccg tcgatcacgt aactgatgtt tccgtttcct
     7381 aaccattcgc ggttctttat cttggaatcc gtataatacc cttctcctgc agaagtagac
     7441 ggaacggatt ctcccaacca gttgtaacgg cgggcgatgg gatccacatt gaaagtattt
     7501 acagaattat acgttccgta aagtgacagc gaaagtccgt caagaaacag atcgtctttc
     7561 ttataacgaa tagaagggat cacagattca ctcttcattt ttacgccacc gtaaacggca
     7621 tccatcgtag caccagtctg tacatcttta tcattcttcg aaagaataat gcctgcaagc
     7681 agatagtcgg cataaggctt attggttatt cccgtctcca ggcggatacc tcctgaccgg
     7741 taggcatcat taaagcgctt tacccaccgc tcgtctatct tcttattggt agccagatcg
     7801 atgatgggca caaacacttt ataatcattg tcggaatagt tatagaaagc attggcacgc
     7861 accgtgaaac ctgttttcag atgggtatag gctccattca ccgagacttt atgagtattg
     7921 aaagagccaa aagaataggt cgcatccaga taattggcat ctctacggct gacgatattc
     7981 accgctcctc ccaaggcatc ggcacccaga tttacaggta ataccccttt atatacctct
     8041 acacgctcag ccatgttagc cgagatatta gcgaggttaa aagacgatcc gaaattatcc
     8101 atcggtattc cgtccaaaaa gaatttcacc tgattgcccg aaaatccgtt caagctgaaa
     8161 ttatagttag accccatacc accttcctca cggatacgga cactcgacac attgttcaat
     8221 aatttgttga gaggtgcagc gctattatac gctttcttga tgtcgagtac cgatatggca
     8281 tacgcctgct cctgctgccg gcgagcttca gattttccaa tcacctgtac ttcttccagc
     8341 tcttccgcct gggtatcgat ctctatgtcc ggaatccggt tcacttttcc ggcagtcaca
     8401 tgtatcggca cctttttagt tttcactcct atgcccgata caactatcgt ctgactgccc
     8461 gccggcacat cattgatatg ataaactcca ttctcgttgg tatatccgcc aatataaaca
     8521 ccttcaatgg caactgcaac cggatagtaa ggttgcttct gttggtcgac gattcgacct
     8581 gtcactatac ctttactttg ttgttgctgt tcgccggcat gcataagaac ggctgacagc
     8641 atagaaaaaa gacagaataa agctactctg tacaacactt tgtggttcat taatcactct
     8701 gtttaattag tccgcaaagg tacgtatatc gacaccggac gacaatcacc atatttaggt
     8761 attcaccgaa actccgatac ctaaatacaa tgataaaaaa aatctctctt ccagaggcct
     8821 gtctcattcg gatgaacgct tcaatcgaat gctgcgtggc gaggtaccaa atgacttttt
     8881 acagaagttt gagaaatgcg gtaaagattc gaacccgaat ttataacaga tttcagagat
     8941 ggtagcctct gtattctgaa gttcgtaaat gatctcctct ttgcggcggc taagcatcca
     9001 ctcatacacc ggctcatgaa aaacattatc gaaaatcctc ctgaatgtag tctggctata
     9061 tcctccaagt ttagcaaact cttcaacagt cttcaccttc ttatagttct gatatacaaa
     9121 gcactcaaac gaagaagcat atttagagag aggatgtacc aaggaagcca ggtcataatc
     9181 cgaataaaaa taaccgagta tgaaagcaag ctctttccgc tttaatgata agagatcccg
     9241 acaaatcttc ttttcgctca gataagtacg tgcagactca agaaaatgtt gaagttcggg
     9301 aataatgggt aagggtgagg gaattaacgg aggatcagtc tccttcatga tacgattata
     9361 ccggatatca caaaacaatt caggttgatt aaactgataa tagatacatt ccacatcggt
     9421 catggccagc atttctattt tcgaactgat gggctgaagc ataaattctc cggctttaag
     9481 cattgttccg gcatactccc ggctattcac cagcatttct cccttgataa gaaacaaaat
     9541 gaaattctcc tcacattttt gtgcaggata atggaaacca cgtctatggt aaacatggaa
     9601 aatggcatta ggaactgact ttttacagtt ctgacacatc atgggatctc cacaaacgga
     9661 gctgggcata tatacgggtg tgtttgtttg tatgtttacg acaaatgtaa gagaattatt
     9721 tagaaagaca ataaaagaag gaataaaaaa atagccctgc gaaaaggcag ggctatcaat
     9781 tacatctctt ggtatatggt tattgggcag tttgctcttt gtcttctgct gcattccatt
     9841 cactaacctt cggagtaacc gtcatctcgg tacctcctgc aggcaaggtc aaaatataga
     9901 gtatattctt acctacctcc catttggaat tgtcgggaag tgtcactgtt ttgtcaccac
     9961 tgaatacctg aactccatca tcatctttac ttgtgtaagt cacagtaatt actttttttg
    10021 ctacatcctg aggaaacaac ataagagatg cgtcttcgcc acccagcata tagtaacttt
    10081 tattttctac aacatttgga gactgtgtaa cggtataagt gtattcttta gaggttccac
    10141 ttgtaacatc ccatgctccg tttgatgcgc taaaagtata tttagctgta cctcctttta
    10201 tatcggcaat cttcacggca gttactgtat atgtcagatt tgtatttccc gggatatacg
    10261 caaaattaat tcgggataat atatgtttaa aattcaaagt cagcttacct gcatttacac
    10321 cttccgaagt ggccgtttta ttactttcgt atgcgactac caaatctccc ggttcatcgg
    10381 cctctttatc aactgtataa ttaaacgaag gatatcctgc agtaccggta tcgggaatgc
    10441 taaaatcgct aatcagcgta gaaggatacg caaagaactg cactgattta ctcgcatccg
    10501 aaggccaata ataagtttta gtatcagaag tggcttttgt ccaagttgta ttatctattg
    10561 tttcaaacaa aacaccattc atataagcag tacccaattc agcggtagta ccgtcaaaag
    10621 cagttccggt aatataagag tgcactttaa aattacctaa attccccata ttggtaaccg
    10681 ccgctcttgt ggtattcttc acaatcgcat tgaacccgat ctccgcagtt ttcgccgcct
    10741 tctcaatctc ctcattctgt gagcaacctg tgattgccaa tgcagcaact gccgcaaata
    10801 aaatcttttt cataatagta tgttttataa attaataatt atctctttta tctgcctacc
    10861 ggtgtcattc caccggtatc actatatctg tttcatcctc ccaatcatcc acatccccat
    10921 tcataccgcc gttaccatcc ggaggagttt ccacatcatc tacttttatt tcatcttcga
    10981 taggaacatc aatttccggt ttatcagttt ctccaccagc ctccgatttg tgtatcactt
    11041 cggttacatc aaccttcact tcctgcactg tatcatccac cttcagcagt agcaaattca
    11101 aagatacttc cgtattctcg gcacgagtac gtacgatctg agagattcca aaagtcgtaa
    11161 aacttccctc gattgtatct tttcccctaa ctacatcaaa atagatcgga cagccgtcac
    11221 acaaactaaa acttttgcct aacaaataat gatcggccat ccccactaca ctgccaaaga
    11281 cttgggatat atttttaatc ccggttactt taatgctgaa gtggtaagtt ttcactacca
    11341 gcttcggaga tagtttcagt atcaaagatt catcgctttt ttccaccatc aactcgtcca
    11401 cacaagtcgt ataaaagtcc tcaggccccc aaaccatctt ctctgtaccg gcaattccaa
    11461 aattacaaag accggtataa gtttcaatcg tctcgtatga ctcatcaccc cggaccaata
    11521 cggtttccgt atcataattg tagactacca cggaatagat accaggggga actcctacat
    11581 gccctccttt cacaggcaga taggtgtcta ctttacgtcc gttgtcccct ttcggataga
    11641 aaataatccg aactccttcc ggcaacttct ccgtcactcc gctccaatcc agccgcactt
    11701 ccacaccact caccggataa tcgtccagaa tatcccgccg gctgcatccc gtcaccacca
    11761 gaaacgagag gagaaccatg caaagcaacc ttgttatatc tttcattcat tatcatctcc
    11821 ttgctgttat aagccacacc aaagatactt ttgccttggt ggggcctatg aagttatagc
    11881 gtgcactact tttccaaacc aagtctccct cataaggagt gtacttcttg tactccgtag
    11941 tcagataacc tatgcccagg ctgaattcaa acgagagatg ccgtgcaatc tgctttgcat
    12001 atccataagt cagccctgaa gctgcataat atcttccttg atagccgtct cctttaaact
    12061 ggaaatcata aattccccct tcggcataag ctccaatgaa atgtcccgcc aagcggttcc
    12121 tccgcttccg gttgcccaac cagcaacgac cttcaacgcc tcccgaaagc aattgatagc
    12181 aaaactcccg gctactattg agccaccacg gacatttata ctcggcattg accgaccagc
    12241 gtctgttcaa tggtatttcc acctctatat tcggtgccaa tgccaggtcg tatagcaggt
    12301 tgtttttcag tgcaagcact gttctctgtt ctattattac tggtgtttct atttttccct
    12361 cttccgggac caccggttga ggatgtacga atttcactcg gggcaataca ttcgccgtac
    12421 tcaaaaacac accggcagct ttatcatccg gtatgggtac aggtgaatgt tctctgtata
    12481 catataaaag cggtaagatt ttattcataa tatagcggta tgcttctcca ccgttcaacc
    12541 tgcgtaataa attctcacat ttcatccggt catcgcggtg ataatcgatc aacatcagca
    12601 catcctcacg atccggaacg tggaggtcag cctgcactct ttcacgtaac agtgaccaat
    12661 ccttctggtt tacaccaatc atcattctgg tccaggcatc cggcattgct accatggccc
    12721 ggctttctcc cgaaagcaga aagagaaaaa caaaaagggt cagtatgcag atacggtttt
    12781 ccataatttg tctgtttgtg caatacaaat atagaagttc aaatcgatac ataataattt
    12841 aatcaaagct aaatacaagc tctgaatgct tctgtgaaac gattgaaagg aatttgcaag
    12901 tttggcggtg aagcaccccc gcacttgggt agctttccgg ccaatgccgg cctctaaaag
    12961 tgggtactgc cgttgcttaa atcttcttac ttaccacctg acttacttat cccagcaaga
    13021 aaatagatct gtctctacga catacgttgt ccgacatggg ggtgtcagac cgtccgacac
    13081 ccccatgtta aacctcccga catccccatg tcagactatg aagagtggga acctaatgaa
    13141 gaaagctttt caaggaaagt gaagggaggt taaaagcaaa agagttattg ccgatgttta
    13201 gcccacttgt aaaagagaac agtaaaaaac agtaaaagaa actcaaagag agccaatatt
    13261 aagaagaata tttggataat agataagaga aacctacatt tgtacagtga tttttttcat
    13321 agtattagat ttaaggttaa caaaaggttg gagtcaggcg tgactccttt ttttttgcct
    13381 tttttatctg agtaactggt aaactcctcc tgccagaacc cgaataacgc ctttcatttc
    13441 aagttcaaac agaatagcac tgatcttatt aatgggaata tcggcctgaa ccatcaatgc
    13501 gtttatttgc agatcgccca gctttccgag aatatcgaca attctcagtt cctcggcaga
    13561 cagatccgga aagaggtttc gctgtacggt ttccggcttg acacttttca aatcgctgtc
    13621 ccagcccatt gctttcacaa agtccgatgc agactccagc aaaacagctt tgttatcttg
    13681 tatcaactgg ttgcatccct ttgaatattc gtccgtgacc cgcccgggaa aagcaaaaca
    13741 atcgcgatga tagcttccgg caatatccgc tgtaatcagc gaaccgcctt tagcggcaga
    13801 ctccaccaca atagtagcat cactt
//
