LOCUS       gnlProkkaCJPEIBOF_184  13841 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CJPEIBOF_184.
ACCESSION   gnlProkkaCJPEIBOF_184
VERSION     gnlProkkaCJPEIBOF_184
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-30 19:33:05
            Original ID  :: gnl|Prokka|CJPEIBOF_184
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13841
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..582)
                     /locus_tag="ctg112_1"
                     /transl_table=11
                     /translation="MLIILKQDDSCQVAQTTCTTNSLEIRYKDYSVLKKTLDLNTKSIN
                     SNSCIELIIYGTHGNEKEICKLTKPDIKDLSYFFKGKVCRLVLDACHSACHIPHFKEML
                     TDDGIILCHVGICQVNSIETKTGKDTYERWINGNKEGLKVWSDGIVPAIYTQKNNTLTY
                     YECSKFEVDINHPFTETEFKTYCLNLKSKGI"
     protocluster    1..13841
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[10529:12959]"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10530..12959
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
     cand_cluster    1..13841
                     /SMILES="NC([*])C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /kind="single"
                     /product="NRPS-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13841
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS-like"
                     /region_number="1"
                     /rules="cds((PP-binding or NAD_binding_4) and (AMP-binding
                     or A-OX))"
                     /tool="antismash"
     CDS             930..2099
                     /gene_functions="other (smcogs) SMCOG1054:hypothetical
                     protein (Score: 219.1; E-value: 2.2e-66)"
                     /gene_kind="other"
                     /locus_tag="ctg112_2"
                     /transl_table=11
                     /translation="MAVKILSVDDELDLEVLLTQYFRRQIRKGEYEFAFAHNGLEALQK
                     LLETPDFDIILSDINMPEMDGLTLLAKVNELKNPAMKCIMVSAYGDMDNIRSAMNKGAF
                     DFATKPIDLDDLSRTIEKAIEQVRYIRESQQEHNQLESIKNDLAIAGEIQQTILPRSFP
                     PFPELTEVVDIYASMTPAKDVGGDFYDFFQIDDERIGLVIADVSGKGVPASLFMAVSRT
                     LLRATALRGVSSAECLTYANKLLCKESLDSMFVTVFYGIYHYKTGMMDYTNAGHNPPYL
                     LRGGRTVECLPVASNFVVGVFDDIEFESNTLTFGIGDTLLLYTDGVTEAFNDKREQFSE
                     SNLQDILASMHESSSAKEVVTSVLQSVKTFSGDYPQSDDITLLSLQRIK"
     CDS             2118..2423
                     /locus_tag="ctg112_3"
                     /transl_table=11
                     /translation="MEKYEIHFVGSVLDSNTSGDEQAKIVALIEQGHSVALNLSGCSYV
                     SSAGLRVMLYAFKLAKAKSRDVCLVGVSQEVKDVMHMTGFDKFFRFYQTLDELSQP"
     CDS             2438..2866
                     /locus_tag="ctg112_4"
                     /transl_table=11
                     /translation="MTLLQFRPVDGRLDEILSMLMHSREVASHPSLSYAIRLVSEEIIV
                     NILNYAYPQQAEGYLTLCLWDEDGEITLEFIDGGIPFNPLDKADPDISLPLEQREIGGL
                     GIFLVREMMDDVAYTYVNKENRLTIKKKYLQPTDEPVS"
     CDS             2863..4464
                     /locus_tag="ctg112_5"
                     /transl_table=11
                     /translation="MIKLNENIIRWIIAVPCILLTVCLVLYRAYRHSASDRERLALSLE
                     EFRDKEKKSVLIQRVSQQMEEIAYQQKDISEKRRQEAVAQTQKANRMQQQAELARERAL
                     AAQLEAEKAYRMADEQKNLAMERQLQAEQSKRVADTLAFLALGRSLGTLSVTQYRSGNM
                     ELASLLAYTAWWFTKRYDGDVYHPAVFNALSLSCRQDQLWFGHKGAVTGIKLLSGGEEK
                     ARAGRNPLPGLVTVGKYGEMIRWKSENGQTYTSELLLNDPCYDFRDVLLRSDSQMYALS
                     YCGQLISTDSAGIVTRFLPKGEYRQLISIASNLVLAVSTTGIYSFDCINHEIQPYFQPE
                     HSITCVGQMEGYLYVFFKNGTVALLSSDGTFLRFIDSLPENSVVTAFCPLTNERYAIGY
                     REGVILICDKNGNIRQKLIGHQAAVTAISRKGNKLFSSSYDCTLRLWDLRKGKTESAVI
                     VTSPGWIHTFCFHPDGTSVFIGDEQGRLYRVPVSPDHMATVVRQGLQRDFTREEWEYYI
                     GKQIPFESYYLKTYQP"
     CDS             4461..7298
                     /locus_tag="ctg112_6"
                     /transl_table=11
                     /translation="MKKIVFLIMCLCSVYANSQEGIPFFVNYPASVYQAHNRNFDVVCD
                     SCGNVYFANFEGILHYDYNRWETIYTPGFSRVTRLFRDSEGRIWVGGYNVFGRIERDGR
                     GCITLRTLLSDLDTDSLGELEDMAEIDKRIYLKATSGRYYTVQSDSILTLVQVLPAQLQ
                     EKWRNQSSVSMNRAFSLPGGETISINSAHGLIMDDSGKKERFSVTERNGLCSNAVSGIA
                     ADGRGNLWGATDNGVFHVFIPSLFSRYTSGEGLKGEVISAVSYKGMIYTGTLQGLYVLK
                     QNTFVPVQGISQACWQLCLSPQGELYAASGDGVYVIRDYNHSEKLTDMAAYSLTFIGHT
                     NLLMGTMDGIYQYSADEERIKKISDVEKVVRLEVKKDRSVWAKTLYGEIYLREEGESSF
                     VLQDRESEEVMTEYTDNDGCHWQTNLKGKEVQVHHSQIDTEKFNQCLYAIRNYVVRVIY
                     IEEDRAAWFGGDFGLIRMDLEKARTFTPVAPRIYLREIYLNRDSVYWGGDLPEESGGAD
                     WQINSTVPRLGNDVRSIRFSFATDAPCFTGSNEYRYRLVGYDPEWSSWDSGTVKEYANL
                     SSGTYTFCVRARDIYGTESEMKQFRFSLLPPFYLQWYCLILYTVAFGMLLFLLFKWRMR
                     SLLKEKERLEALVGQRTKQLVQQKNEIEEKSLKLEKALKELGQAQDELVRQEKMATVGK
                     LTQGLIDRILNPLNYINNFSHLTSGLLKDLYQNLESVKELLDEDTYLDSVDVINMMRDN
                     LEKIEEHGSNTTRVLKAMEEILRDRNRQLEKTELIGLCRKDMELLSSYYQKEITAMHIA
                     VRTSLPDNPLFIDGNAEQLGKTIMSLLNNGMYAIAKKYGKKAYPAEIGLALESKDGQAV
                     IRLYDNGVGIEQSILDKIFDPFFTTKTTGEAAGIGLYLSKEIILNHHGQIAVRSEKDEL
                     TEFTITLPLWEEKSV"
     CDS             7321..8157
                     /gene_functions="regulatory (smcogs) SMCOG1003:sensor
                     histidine kinase (Score: 140.9; E-value: 1.2e-42)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg112_7"
                     /transl_table=11
                     /translation="MEKNISQEKRIEELEARLKEQEKLGSLGLLSAGIAHEIQNPLNFV
                     INFSKLSGQLLADLADRVDEAKARIPEAELEDIKDILSGLRENVDKIKEHGDRAISIIR
                     GILLYSRGKEDEFMPTQIQKLTKEYVWLAYHAMRANYKNFNIAIREDYAKDIPSIRLIP
                     QDFSRAVLNVMNNACYAVWKKWQNAPEGYSPEIMVTLEKLDKRIVLSIRDNGEGMSPEV
                     KRKLFDSFFTTKPVGQGTGLGMAIVRDIIENKHHGKVLFDSVLHEYTCFRFIIPIA"
     CDS             8154..10517
                     /gene_functions="transport (smcogs)
                     SMCOG1082:TonB-dependent siderophore receptor family
                     (Score: 169.9; E-value: 2.1e-51)"
                     /gene_kind="transport"
                     /locus_tag="ctg112_8"
                     /transl_table=11
                     /translation="MKPCLLYILCCFGVVQLSAQPADNIRNSFVKAETFYKSGDIDEAC
                     RILEENLSSFQGTMHTEACRLAALCCLALDRFPEAEKYVSLLLKDEPYYYISLQDPERF
                     ADMVRKHRETKVTLVTASQQVETPEEAPVPVTLITEEMIRAIHARCLRDVLIAYVPGIS
                     GLSSNEEMNLAMRGVYSPEQENILIMQDGQRLNSYITNAVSPDYGISLAKVKQIEVLRG
                     PASSLYGSVALTAVINIVTKDGVDVRNGSVSVSAGNRGQLAADLLLGKHDMNMDFMAWF
                     SLYRATGESVFVPAEKQYALYPRDGFIRLDNYSGFPAMDGGIKLQRGNLLFSFSMNYAK
                     KRQPYSMWLFSSPYSYERFRTFDGSGPGYSRWSAREQTVYSRTWQRITFSAAFYTDWNK
                     NVHYETAGDTLQDYPIFPNYDYQPIYPTRGVFQYIRWMDFNVGFNGRVNYAYDWGKLGK
                     GNMLGGVEWNRYTLYDSEYLEGMNFKEIVRTWIEKRLYTGHEMNTDAFLQIKHNLHQNW
                     IVNAGIRYDYKRRSNKRTLQAFSPRLSLIYLRNGLNIKASYSRAFVDAPYYYRNNEMDT
                     YSGGENLQAEYLSSYQVTCAYHHSPSHIDVECNLFYNRASHFLFTQPETRVYENAGSLD
                     MGGVEVVARYKADRLSLDGNLCFQKVLNYTNFFVTDGSVNNVPGFSMNLVANYFLLKKK
                     VQSWSAHLKLNCSSHCYTQVSVLEDGLNGDATNYTVRLPGYAVFSFTTRYKYKRIEGSL
                     GIENLFNNRYECGGATVPIRQKGRWISASILYNF"
     CDS             10530..12959
                     /NRPS_PKS="Domain: AMP-binding (12-401). E-value: 9.8e-84.
                     Score: 273.1. Matches aSDomain:
                     nrpspksdomains_ctg112_9_AMP-binding.1"
                     /NRPS_PKS="Domain: PP-binding (509-568). E-value: 2.7e-10.
                     Score: 32.6. Matches aSDomain:
                     nrpspksdomains_ctg112_9_PP-binding.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     259.5; E-value: 8.4e-79)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg112_9"
                     /sec_met_domain="AMP-binding (E-value: 1.7e-88, bitscore:
                     286.3, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 4.8e-11, bitscore:
                     32.6, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTNIQKNLSRSLSTWGDKPAVVAKDGTVSYQMLERYSANIAQSI
                     RQRLSVTDPSGLRNICIGVCMERNKILVPAILAIFRLGATYLPIDPSLPDNRKRYMAEN
                     ADMVLLLTDSSNEVGGIPSVRQLYLNGEQLSEPVVGDYTEVLPDDCAYIIYTSGTTGNP
                     KGVRISYRNLDTFTRNLVDKKLYHLSDPANRYLAFASISFDASILELMMCIPVGGTLIL
                     AGEDERRDISLLDELIRREKVNIAFFPPSLLGMFADLDFPSFKTLLFGAEAIGEKLFNR
                     LKQQPYRLMNVYGPTENTVLSTIRIVGKDTSYDDIGYPLKGTVCYVLSENLQQTTLGAT
                     GELCLGGPQVSLGYIGNVQLNEKSFISYDGERLYRTGDLVQQQPDGSIRFIGRKDTQVK
                     IRGFRIELTEIAERLNRDPDVERAHVVVVERNGRQLLGAYLQPSVSGNFHPEEVKERLR
                     AELPYYMIPNLWQVVDHFQRTINDKIDVRALPAFTSLELKYVPPVHPGEVILCGILKEM
                     LGLPQVSVEADLIDDLGLTSLDMLRLVTEANKKGCPINVSAVYTARNLRRLLLVPRHEP
                     IYWYRQQNLKKPVIILVCGSAYFNHLYFNLADRLYPKYDFLVVDAIYDHFNKVATDIPE
                     LLEYYVRTVQPMIRERTVYALTGFCMGAELAVGLAEMLHRSMGIMPKVFALDGQAWQNP
                     ALCQNYPLLVFPGDTDEMVRERNEIINIYFRTTPNLIYQGEVIVLLSGLFHQQAGLSPE
                     ESWTEENYRIFRTEYDNCERLWNKYYPNAPVLRLPADHWHFLEGESLEQLITVFLK"
     aSDomain        10566..11732
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg112_9_AMP-binding.1"
                     /evalue="9.80E-84"
                     /label="ctg112_9_AMP-binding.1"
                     /locus_tag="ctg112_9"
                     /protein_end="401"
                     /protein_start="12"
                     /score="273.1"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="LSTWGDKPAVVAKDGTVSYQMLERYSANIAQSIRQRLSVTDPSGL
                     RNICIGVCMERNKILVPAILAIFRLGATYLPIDPSLPDNRKRYMAENADMVLLLTDSSN
                     EVGGIPSVRQLYLNGEQLSEPVVGDYTEVLPDDCAYIIYTSGTTGNPKGVRISYRNLDT
                     FTRNLVDKKLYHLSDPANRYLAFASISFDASILELMMCIPVGGTLILAGEDERRDISLL
                     DELIRREKVNIAFFPPSLLGMFADLDFPSFKTLLFGAEAIGEKLFNRLKQQPYRLMNVY
                     GPTENTVLSTIRIVGKDTSYDDIGYPLKGTVCYVLSENLQQTTLGATGELCLGGPQVSL
                     GYIGNVQLNEKSFISYDGERLYRTGDLVQQQPDGSIRFIGRKDTQVKIR"
     aSModule        10566..12233
                     /complete
                     /domains="nrpspksdomains_ctg112_9_AMP-binding.1"
                     /domains="nrpspksdomains_ctg112_9_PP-binding.1"
                     /locus_tags="ctg112_9"
                     /monomer_pairings="X -> X"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       10758..10799
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg112_9_0001"
                     /evalue="3.50E-03"
                     /label="NRPS-A_a2"
                     /locus_tag="ctg112_9"
                     /protein_end="90"
                     /protein_start="76"
                     /score="11.0"
                     /tool="antismash"
                     /translation="LAIFRLGATYLPID"
     CDS_motif       10980..11036
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg112_9_0002"
                     /evalue="1.50E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg112_9"
                     /protein_end="169"
                     /protein_start="150"
                     /score="26.8"
                     /tool="antismash"
                     /translation="AYIIYTSGTTGNPKGVRIS"
     CDS_motif       11538..11624
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg112_9_0003"
                     /evalue="1.00E-09"
                     /label="NRPS-A_a6"
                     /locus_tag="ctg112_9"
                     /protein_end="365"
                     /protein_start="336"
                     /score="30.7"
                     /tool="antismash"
                     /translation="LGATGELCLGGPQVSLGYIGNVQLNEKSF"
     CDS_motif       11697..11759
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg112_9_0004"
                     /evalue="1.50E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg112_9"
                     /protein_end="410"
                     /protein_start="389"
                     /score="36.2"
                     /tool="antismash"
                     /translation="FIGRKDTQVKIRGFRIELTEI"
     aSDomain        12057..12233
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg112_9_PP-binding.1"
                     /evalue="2.70E-10"
                     /label="ctg112_9_PP-binding.1"
                     /locus_tag="ctg112_9"
                     /protein_end="568"
                     /protein_start="509"
                     /score="32.6"
                     /tool="antismash"
                     /translation="LCGILKEMLGLPQVSVEADLIDDLGLTSLDMLRLVTEANKKGCPI
                     NVSAVYTARNLRRL"
     CDS             12964..13839
                     /locus_tag="ctg112_10"
                     /transl_table=11
                     /translation="MQTENFTLGKKELLILLGLTLVLPFPINWALIELNPLTLMAGADD
                     VPTWIGFGGSYIGGIIGGIISIMILNKTLQQTGVLHHDLKLLQLDTIIYTQQQDWFTGF
                     KQELAENLKSIDLYVLNTVVSSISMKNYAYAKEVLTEINKGLEYQMVAASFSFTSTHLS
                     SEEKKYMNLVRRVQTEYSSFIKDILYYIPLAETISSRKKLNYDQLMDYTLSQYDYLQGQ
                     EGESTASGAIIPRVMEIDPSDDIRKELERIMEERLTGRTYLYHLKSDLAEATHQLIIYE
                     ENRINSILHKP"
ORIGIN
        1 aattcctttt gattttaaat tcagacaata agtcttaaat tcagtttcgg taaaagggtg
       61 attaatatct acttcgaatt tgctacattc gtagtaagtt aaagtgttat tcttttgagt
      121 atagatagct ggaacgattc catccgacca tacttttaat ccttccttat tgccatttat
      181 ccaccgttca taggtgtctt tacctgtttt agtttcgatg ctgtttactt ggcagatacc
      241 tacatgacat aatatgattc catcatctgt taacatctct ttgaaatgtg gaatatggca
      301 ggcgctatgg caagcatcaa gaactaatct acaaactttt cctttgaaga aatagctcag
      361 atcttttatg tctggtttgg ttagtttgca aatttccttt tcatttccgt gtgttccgta
      421 aataattaac tctatacagc tattgctatt aatagatttt gtgttcaaat ccagagtttt
      481 tttcagtaca ctataatctt tgtatcggat ttctaaagag tttgttgtac atgtcgtttg
      541 tgcaacttga caactatcat cttgttttaa aataataagc ataatagtaa ttcgtaaaaa
      601 gttcctactc tttcttcggc ttttcggaat ccgccgtttc tatttattct ttgtaagctt
      661 acggtgacaa aagtgagaag aaaagttcca tcttaaaaat ataatttctg aatacggaat
      721 agtttctttc aggagtgtaa atcaatcttt caggtgctgt cttctaaggc acgaaagcaa
      781 tatacctgta tgcttataag acaatatcgt ccattcggaa aaacattctt cctgtttaaa
      841 atataaaatt gtaaccgggt cggtcacgct ctatttttgc catcataaac gtcagaacaa
      901 acggttgaaa ttcataaata acaatagata tggcagtaaa aatattgagt gtagatgatg
      961 aactcgattt agaagtatta cttacccagt acttcaggcg acaaatacga aaaggtgaat
     1021 acgagttcgc ttttgcccat aacgggttgg aagctttaca gaaacttctg gaaactcccg
     1081 atttcgatat catcctgagt gatattaata tgccggagat ggatgggttg accctattgg
     1141 ctaaggtcaa tgaactgaaa aatccggcaa tgaagtgtat aatggtctct gcttatggag
     1201 acatggataa catacgttct gctatgaaca agggagcgtt tgattttgca accaaaccga
     1261 tcgatttgga tgatctgtcg cggactattg aaaaggcgat cgaacaggtt cgctatatcc
     1321 gtgagtcaca gcaggagcac aaccaactgg aatctatcaa aaatgacctg gccattgcgg
     1381 gagaaatcca gcaaacgatt cttccccgtt cctttcctcc ttttccggaa ctgacggaag
     1441 tggttgatat ttatgcttcc atgactccgg caaaagatgt aggtggcgat ttttatgatt
     1501 tcttccagat tgacgatgaa cgtatcgggc tggtgattgc tgacgtatcc gggaaagggg
     1561 tgccggcatc cttgttcatg gcggttagtc ggaccctgct ccgtgcaact gctcttcggg
     1621 gtgtttcgtc ggcagaatgc cttacttatg ccaataagtt actgtgtaaa gagagcctgg
     1681 actctatgtt tgttacggtc ttttatggga tttatcatta taaaaccggc atgatggact
     1741 ataccaatgc cgggcataat cccccttatc tccttcgcgg cggacggact gttgaatgct
     1801 tgcctgtcgc ttctaatttt gtggtaggcg tgttcgatga tattgaattt gagagtaata
     1861 cattgacgtt cggcatcggt gacactttac ttctgtatac ggatggtgtc acagaggctt
     1921 ttaacgacaa gcgggaacaa ttctcggaaa gtaacttaca ggatatattg gcgtctatgc
     1981 acgaaagtag ttccgcaaaa gaggttgtta cgagtgtatt gcagtctgtt aagactttct
     2041 ccggagacta tcctcagtcc gatgacataa ccctgctttc tcttcaacga atcaaataat
     2101 attaaaataa aagaacgatg gaaaagtatg aaattcattt tgtaggttcc gtcttggatt
     2161 caaatacaag cggtgacgaa caagcaaaaa ttgtagctct tatcgagcaa ggacattctg
     2221 ttgcattaaa tctcagcggc tgttcttatg tatccagtgc cggattgaga gtcatgcttt
     2281 atgcctttaa gctggcgaaa gctaaaagta gagatgtttg ccttgtcggt gtgtcacaag
     2341 aggttaaaga cgtgatgcac atgaccggat tcgataaatt ctttcgtttt tatcagactc
     2401 tcgatgaatt atcacaaccc taaaaattac ctgagcaatg acgttacttc agtttcgccc
     2461 tgtcgatggg aggttagatg aaattcttag tatgctgatg catagtcgtg aagttgcttc
     2521 acatccttcc ctgtcttatg ccatccgttt ggtcagtgag gagatcattg tcaatattct
     2581 caattacgct tatccgcagc aggcagaagg ttatctgact ctgtgcttat gggatgaaga
     2641 cggagagatt actttggagt ttatagatgg tggtattcca ttcaatcctt tggataaagc
     2701 cgatcctgat atttcattac cgttagaaca acgtgaaata ggaggattgg gcattttcct
     2761 ggtacgtgaa atgatggatg acgtagcgta tacgtacgtg aataaggaga atcggttgac
     2821 cattaaaaag aaatatctgc aacccactga tgaacctgta tcatgatcaa gttaaacgaa
     2881 aatataatcc gttggatcat tgccgttcct tgtatacttt tgacagtatg tctggtccta
     2941 taccgggcat atcgtcattc ggcatcggac agggagcgtc ttgctctgtc tctggaggaa
     3001 ttccgggata aagaaaagaa atcggttctt atacaacggg tcagtcaaca aatggaggag
     3061 attgcttatc aacaaaagga tatttccgaa aagagaagac aggaagccgt tgcgcaaact
     3121 caaaaggcca accgaatgca acagcaggca gagttggcac gggaaagagc gcttgctgca
     3181 caattggagg ctgagaaagc gtatcggatg gcagatgaac aaaagaatct ggcgatggaa
     3241 cggcaactac aggccgaaca gtcgaagagg gttgccgata cattggcttt tctggctttg
     3301 ggacgttcat tggggacact ctctgttact caatatcggt cgggcaacat ggaattagct
     3361 tctctgttgg catataccgc ctggtggttt accaagcgat atgatggcga tgtatatcat
     3421 ccggctgttt tcaatgcatt gtctttgtct tgcaggcaag atcagctttg gttcgggcat
     3481 aaaggagctg ttaccgggat caaactgtta tccggaggcg aggaaaaagc aagagccggt
     3541 cggaatcctc tgccgggatt ggtcactgtc ggcaagtacg gtgagatgat acgttggaaa
     3601 tcggaaaatg ggcagaccta tacctccgaa ttactgttga atgatccctg ttatgatttt
     3661 cgggatgtgc tgttgcggtc cgattcacag atgtatgcct tgtcatactg cgggcagctt
     3721 atctccacgg attctgccgg tatcgttacc cgctttttgc ctaaaggaga atatcggcaa
     3781 ttgatttcga ttgcctctaa cttggtattg gcagtttcca caaccggtat ttattctttt
     3841 gactgtatca accatgagat acaaccttat tttcagccgg aacattcgat aacttgtgtc
     3901 ggtcaaatgg aaggctatct ctatgttttt tttaagaatg ggacagtagc tttactttcg
     3961 tcggatggta catttctcag atttatagac agcttgcccg agaatagtgt ggttactgca
     4021 ttctgtcctc ttaccaatga aagatatgcc attggctatc gtgaaggagt catcctgatt
     4081 tgtgataaga atggaaatat ccggcagaag ttgatagggc atcaggctgc ggttactgct
     4141 atttcccgga aagggaacaa actgttttcg agtagttacg attgtacgct gcgtctgtgg
     4201 gatcttcgta aaggaaagac cgagtcggcc gttattgtga caagtcccgg ttggatccat
     4261 actttttgct ttcatccgga cggtacatct gtctttatag gagacgaaca ggggcggttg
     4321 tatcgggtgc ctgtttcacc cgatcacatg gctactgttg tccgtcaggg gttacagcgt
     4381 gattttactc gagaagaatg ggagtattat atcggtaagc aaattccatt tgaatcctat
     4441 tacctaaaaa cgtatcagcc atgaaaaaga tagtcttttt gataatgtgt ctttgctcgg
     4501 tatatgcaaa ttcacaagaa ggtatcccgt tttttgtaaa ctatccggct tcggtttatc
     4561 aggcgcacaa tcgtaatttc gatgtcgttt gcgacagttg tggaaatgtc tattttgcta
     4621 atttcgaagg tatccttcat tatgactata accgttggga aactatttat acaccgggtt
     4681 tttcccgtgt cacccgtttg tttcgtgatt cggaaggtag gatatgggtg ggaggatata
     4741 acgtgttcgg acggatagag cgtgatggac gcggatgtat tacgttgaga acccttcttt
     4801 ccgatctgga cacagactct ttgggcgaat tggaagatat ggcagaaata gataaacgca
     4861 tttatctgaa agctacatca ggaagatatt atacggttca gtcagattcc attttgacac
     4921 tggttcaggt acttccggcc caattgcagg aaaagtggag aaatcaatcc tcagtctcaa
     4981 tgaatcgggc gttttctcta cccggaggag aaacaatctc gataaactct gcccatggat
     5041 taataatgga tgacagtggg aaaaaagaac ggttttccgt aactgagaga aatggcttat
     5101 gcagtaacgc tgtttcgggt attgcggccg atgggcgtgg caatctctgg ggagctacgg
     5161 ataacggtgt gtttcatgtt tttattccct ctttgttcag ccgttatacc tctggtgaag
     5221 gtctgaaggg agaggtaata tcggctgtct cttacaaagg aatgatatat accgggacct
     5281 tacagggatt atacgtattg aagcaaaaca cttttgttcc tgttcaggga atttcgcaag
     5341 catgttggca actgtgtctt tctccacaag gagaattata tgcagcgtcc ggcgatggtg
     5401 tgtatgtgat ccgggattat aatcattcgg aaaaactcac agatatggca gcttattcat
     5461 tgacattcat tgggcataca aaccttctga tgggcactat ggatgggatt tatcaatatt
     5521 cggcagatga ggaacggata aagaaaattt ccgatgtcga aaaagtcgtt cgtctggaag
     5581 tgaagaaaga tcgttctgta tgggctaaaa cgttgtacgg agaaatctat ttgcgggaag
     5641 agggcgaaag ctcttttgta cttcaagaca gagagagtga agaagtaatg accgagtata
     5701 cggacaacga tggctgtcat tggcagacaa atctgaaagg aaaagaggta caggtacatc
     5761 attcgcaaat tgatacggag aaattcaacc aatgcctgta tgccattcgg aattatgtcg
     5821 tgagggtgat ttatattgaa gaagacaggg cggcatggtt cggcggtgat tttggcttaa
     5881 ttcggatgga ccttgaaaag gcccggacat ttactccggt tgctccccgc atctatcttc
     5941 gtgaaattta tctgaaccgt gattctgtct attggggagg agatttgccg gaagagtccg
     6001 ggggagcgga ctggcagata aatagtacag tacctcgttt ggggaatgat gtacgttcca
     6061 ttcgtttttc atttgctacc gatgcgccct gtttcaccgg ttccaatgag tatagatatc
     6121 gcctggtcgg ttatgatccg gaatggagtt cgtgggattc cgggactgtg aaagagtatg
     6181 ccaatctttc gtcgggtacg tatacgtttt gtgtccgggc ccgtgatatt tacggcacag
     6241 agagtgaaat gaaacaattc cgcttttcgt tattgcctcc tttttatttg caatggtatt
     6301 gtctgatcct atataccgtt gcttttggaa tgctgttgtt cttattgttt aaatggagaa
     6361 tgcgcagttt gctgaaagag aaggagaggt tagaggccct tgtcggccaa cgtaccaaac
     6421 agttggtaca acaaaaaaat gaaattgagg aaaagtcctt aaaattggaa aaagcattga
     6481 aggagctggg ccaggcacaa gatgaattgg ttcgacaaga aaaaatggct actgtaggta
     6541 aactgactca agggttgatt gaccgtattc tgaatccgtt gaattacatt aataattttt
     6601 cccacctgac ctcaggatta ctgaaggacc tatatcagaa tctggagagt gtaaaagaac
     6661 ttttggatga agatacctac ttggattcgg tagatgtcat caacatgatg agagataatc
     6721 tggaaaagat tgaggaacat ggaagtaaca ccactcgtgt actgaaggcc atggaagaaa
     6781 tcctgagaga ccgtaacagg caactggaaa aaacagaatt aatcggttta tgccggaaag
     6841 acatggagct attgagcagt tattatcaga aggagattac ggctatgcac attgcggttc
     6901 gtacttcctt gcccgataat ccgttgttta ttgacgggaa tgccgaacaa ctgggaaaaa
     6961 ccattatgag tcttcttaac aatggtatgt atgccatagc caaaaaatac ggtaagaaag
     7021 cctatccggc agagattggc ctggcattgg aaagtaagga cggacaggca gtcattcgcc
     7081 tatatgacaa tggagtgggg atcgagcaga gtattctgga taaaatcttc gatccgttct
     7141 ttactaccaa aacaaccgga gaggcagcag gtatcggttt gtatctgagt aaggaaatca
     7201 tattaaatca ccatgggcag atagcagtac gttctgaaaa agatgaattg acagaattca
     7261 ctatcactct gccattgtgg gaggaaaagt cagtataaat aaacatagaa cagattgatt
     7321 atggaaaaaa acatttcaca agagaaacga attgaagagt tggaagcacg gctcaaagag
     7381 caggaaaagc tgggatcatt gggtttgttg agtgcaggca ttgcacacga gatacagaat
     7441 cctttgaatt ttgtcatcaa tttcagtaaa ctgtccggtc aattgttggc cgacctggcc
     7501 gatagggtgg atgaagcaaa agctcgtatt ccggaagcgg aactggaaga tatcaaagat
     7561 atactttccg ggctgagaga gaatgtggac aaaatcaaag agcatggtga tcgggctatc
     7621 agcattatcc gtggtatttt gctttactct agggggaaag aagacgaatt catgcctaca
     7681 caaatacaaa aattgactaa agaatatgtg tggctggctt atcatgccat gcgggccaat
     7741 tataagaatt tcaatattgc tatccgtgaa gattatgcta aagatatccc ctcgatccgg
     7801 ctgatcccgc aggatttcag tcgggcagtc ttgaatgtga tgaataatgc ctgctatgca
     7861 gtatggaaaa aatggcagaa tgctcccgaa ggatattccc ccgagataat ggtgacctta
     7921 gaaaagttgg ataaaagaat tgtactttct attcgtgata acggagaggg catgagtccg
     7981 gaggtcaaac gaaaactatt tgactctttt ttcacaacaa aaccggtggg gcaggggaca
     8041 ggccttggta tggcaatcgt tcgtgatatt atagaaaaca aacaccatgg aaaagtattg
     8101 tttgattcgg tcctgcatga atatacttgt ttccggttta tcattcctat cgcatgaaac
     8161 cttgtctgct atatatcctt tgctgctttg gggttgtgca actgtcagct cagccggcgg
     8221 ataacatccg taattcgttt gtaaaggcgg aaacatttta taagagcgga gatatcgatg
     8281 aagcttgtcg tatcttggag gagaatctgt cgtcttttca aggtacgatg cataccgagg
     8341 cgtgccgttt ggctgcatta tgctgtttag ctttagaccg cttcccggaa gcggaaaagt
     8401 atgtttcgct gttattgaaa gacgaacctt attattatat ctcgcttcaa gatccggaac
     8461 gctttgcgga tatggtaagg aaacacaggg agactaaagt aactctggtc acagcctcac
     8521 aacaggtaga gaccccggaa gaagctccgg tgcctgttac tttaattacg gaggagatga
     8581 tacgggctat ccatgcccgg tgcctgcggg atgtactgat agcttatgtg cccggtatat
     8641 ccggtttgtc ttccaatgaa gagatgaatc tggctatgcg cggggtatat tctcccgaac
     8701 aggagaacat attgattatg caggatggac aacgtctgaa cagttatatt actaatgctg
     8761 tttcgccgga ttatggtatt agtctggcaa aagtcaaaca aatagaggtg ctgcgcggac
     8821 cggcttcttc gctttatggt agtgtggctt tgacagccgt gattaatata gttactaaag
     8881 acggggtgga tgttcgtaat ggttccgtat ctgtcagtgc cggtaatcgg ggccagttgg
     8941 ctgctgacct gctattggga aagcacgaca tgaacatgga ctttatggca tggttctcct
     9001 tgtaccgtgc aacgggagaa tcggtttttg tcccggccga aaaacaatat gctctttacc
     9061 ctagggacgg attcatccgt ctggacaatt attcgggatt tcctgccatg gatggaggaa
     9121 ttaaattgca acgtggaaat ttgcttttta gtttcagtat gaattacgcg aagaaaaggc
     9181 aaccttatag catgtggctc ttttcttctc catattctta tgagcggttt cgtacttttg
     9241 acggttccgg cccgggatat tccagatggt cggcaagaga acagactgtt tatagccgca
     9301 cgtggcagcg gatcactttc agtgccgcat tttataccga ttggaataaa aacgtacatt
     9361 atgaaaccgc aggagatact ttacaagact atcctatttt tcctaactat gattatcaac
     9421 ctatttatcc gactcgcgga gtgtttcaat atatccgctg gatggatttt aacgtaggct
     9481 ttaatgggcg tgtaaactat gcctatgatt gggggaagct ggggaaaggc aatatgcttg
     9541 gcggtgtgga atggaatcgg tatacgcttt atgattccga gtatttggaa ggtatgaatt
     9601 ttaaagagat cgtcaggacg tggatcgaaa aacgacttta cacgggacac gagatgaaca
     9661 cggatgcctt tcttcagatt aaacacaacc tgcatcaaaa ttggattgtc aatgccggca
     9721 tcaggtatga ctataaacgg cgaagtaata agcggacatt acaggctttt tctccccgtc
     9781 tgtcactgat ttatctcagg aacggattaa atatcaaagc cagttattcc agagcatttg
     9841 tcgatgcgcc ctattattac agaaacaatg aaatggatac ctattcgggt ggcgaaaatc
     9901 tgcaagctga atatctaagt tcatatcagg tgacttgtgc ttatcatcat tcaccttcac
     9961 atatagatgt ggagtgtaat ttattttata atcgggcgtc ccatttcctg ttcacacagc
    10021 cggaaacacg tgtttatgaa aatgccggtt ctctggatat gggaggtgtc gaggtcgttg
    10081 cccgttataa ggcagaccga ctgagcctgg atggaaacct gtgttttcag aaagtattga
    10141 attataccaa tttttttgtt accgatggat ctgtgaataa cgtacccggc ttttctatga
    10201 atcttgtagc aaactacttt ttacttaaaa agaaagtaca gagctggtct gcccatttaa
    10261 aattgaattg cagtagccac tgctacactc aggtaagtgt attggaagat ggactcaatg
    10321 gagatgcgac gaattacaca gtccgtttgc ccggttatgc tgtcttttct ttcactacca
    10381 gatataagta taaaaggata gaaggcagtc tgggcattga gaatcttttc aataaccgat
    10441 atgaatgcgg aggagcgact gttcctatcc gccagaaagg aaggtggatt tccgccagta
    10501 tattgtataa tttctaaatc aaactaataa tgaaaacaaa cattcaaaaa aatctttctc
    10561 gatcactctc tacctggggt gacaaaccgg cggtcgtagc aaaagacggt accgtctctt
    10621 atcaaatgct ggaacgttac tctgccaata tagcacaatc tatccgtcaa cgtttatcgg
    10681 taactgatcc gtccggactt cggaatatct gtatcggagt ttgtatggaa cgaaacaaaa
    10741 ttttagtacc tgccattctg gctattttcc ggttaggggc aacttattta ccgatagatc
    10801 cctcgctgcc ggacaatcgt aaacggtata tggctgaaaa tgcggatatg gttttgttgt
    10861 tgaccgattc atcgaatgaa gtaggtggaa ttccgtccgt ccgccaactt tacctgaatg
    10921 gggagcaact atccgaaccg gttgttggtg actatactga agttcttccc gatgattgcg
    10981 cctatattat atatacttcc ggaacaacag gcaatcccaa aggtgtacgt attagttatc
    11041 ggaatctgga tacatttacg aggaatctgg tagataagaa attgtatcat ttgtctgatc
    11101 cggcaaacag gtatctggcg tttgcgagta tcagttttga tgcttccata ttagaactga
    11161 tgatgtgtat tccggtcgga ggaacattga tcctggccgg tgaggacgaa cgcagagata
    11221 tttctttact agacgaactg atcaggcgcg agaaggtgaa tattgctttt ttccctcctt
    11281 cgttgctggg catgtttgcc gaccttgact ttccatcctt taagactctg ctctttggtg
    11341 cggaggctat tggtgaaaag ttatttaaca ggctgaaaca gcagccttac cggttgatga
    11401 atgtatatgg accgacagag aataccgtac tcagtaccat acggattgta ggcaaagata
    11461 cgtcgtatga cgatattggc tatccgctca agggaactgt ctgttatgtt ttgtctgaaa
    11521 acctccaaca gacaactctt ggggctacag gagaactttg cttgggagga cctcaggttt
    11581 cgctgggata tattgggaat gttcagctga atgaaaaatc attcatctcg tacgatggag
    11641 aacggttgta caggacaggt gacctggtac agcagcaacc ggacggttca atacggttta
    11701 tcgggcgaaa agatactcag gtcaagatac gtggttttcg tatcgaattg actgaaatag
    11761 cagaacgatt gaatagagat ccggacgtgg agagagccca cgtagtagtt gttgagcgga
    11821 atgggcgtca attattggga gcttatttgc aaccctcagt ctccggtaac tttcatccgg
    11881 aagaggtcaa agagcgtttg cgtgcagaac ttccttacta catgataccc aatttatggc
    11941 aggtggtaga tcattttcag cgtactataa atgataagat tgatgtccgg gcgctcccgg
    12001 cttttacctc gttggagttg aagtatgttc ctcctgttca tccgggggag gttatcttat
    12061 gtggaatttt gaaggaaatg ttaggtttgc ctcaagtcag tgttgaggcc gatttgattg
    12121 atgatctggg attaacttcg ctggatatgt tgaggcttgt taccgaggcc aataaaaaag
    12181 gatgtcccat caacgtatct gcagtttata ctgcccgtaa tctgcgccga ttattgctcg
    12241 ttccgcggca tgaacctatc tattggtaca ggcagcaaaa cctgaagaaa cccgtaatca
    12301 ttctggtttg tggatctgcc tattttaatc atttgtactt taatttggcc gaccgccttt
    12361 atcccaaata tgactttcta gttgtagatg ctatctacga tcattttaat aaagtggcca
    12421 cggatattcc ggaactgttg gaatattatg tccggacggt tcagccaatg atccgggagc
    12481 gtaccgtcta tgcgcttacc ggcttttgta tgggagctga actggctgtc ggcctggccg
    12541 aaatgttaca tcgctccatg gggataatgc caaaagtttt tgctctggat ggacaggctt
    12601 ggcaaaatcc ggctctctgt caaaattatc ctttgttggt atttcccgga gatacagatg
    12661 aaatggtacg tgaacggaac gaaatcataa atatttattt tcgaaccact cctaatctga
    12721 tttatcaggg agaggttatt gttttgctgt ccggattgtt ccatcaacag gcgggattgt
    12781 ctcctgaaga gtcgtggacg gaggaaaact atcgtatatt ccggacagaa tatgacaatt
    12841 gcgaaagatt atggaataaa tattatccga acgctcctgt tttgcgattg ccggcagatc
    12901 attggcactt tttagaaggg gaatcattgg aacaattaat aactgtgttt ttgaagtaga
    12961 tttatgcaga ctgaaaactt cactttaggt aagaaagagc ttcttatttt gcttggcttg
    13021 actcttgtac tgccttttcc aatcaattgg gcattaatcg aactgaatcc gttgactctg
    13081 atggcgggtg cagacgatgt gcccacctgg attggtttcg gcggcagtta tattggagga
    13141 atcatcggag ggatcatctc gattatgatt ctgaacaaga cacttcagca gacaggtgta
    13201 cttcatcacg atttgaaact cctgcagtta gataccataa tttatactca gcaacaagat
    13261 tggtttaccg gtttcaaaca agaactggca gagaatctca aatctattga tttgtatgtg
    13321 ttgaatacgg ttgtttcgtc tatatccatg aaaaactatg catatgccaa agaggtgttg
    13381 acagaaatca ataaagggct cgaatatcag atggttgccg catccttttc tttcacttct
    13441 acgcatttat catccgaaga aaaaaagtat atgaatctgg tacgccgcgt acagactgaa
    13501 tatagctctt ttatcaagga tattctttac tatattcctt tggcagaaac gatatcttcc
    13561 aggaaaaaac taaactatga tcagctgatg gactatactt tgtcccaata tgattatttg
    13621 caaggtcagg aaggggagtc tacagcttcg ggagccatca taccgcgtgt tatggaaatc
    13681 gatccatctg atgatatacg gaaagaacta gaacggataa tggaagaaag attaaccggg
    13741 cgtacctatt tgtatcacct gaagtcagat cttgcagagg ctacgcatca attaattatt
    13801 tatgaagaga accgtataaa ctctattctg cataaacctg a
//
