LOCUS       c00170_gnlPro..        16293 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CJPEIBOF_253.
ACCESSION   c00170_gnlPro..
VERSION     c00170_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 21:02:43
            Original ID  :: gnl|Prokka|CJPEIBOF_253
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16293
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16293
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[417:6293]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      418..6293
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
     cand_cluster    1..16293
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /kind="single"
                     /product="TPP_fatty_acids"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16293
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_fatty_acids"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /tool="gutsmash"
     CDS             2..214
                     /locus_tag="ctg170_1"
                     /transl_table=11
                     /translation="TKEQKSDNRKKSKTRCLVEHVFGFEEQTMRGLVVRTVGLIRAKAN
                     VALTSLVYNISRYTQIIRLKPELLG"
     CDS             418..1650
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: HBT"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg170_2"
                     /sec_met_domain="HBT (E-value: 9.5e-18, bitscore: 55.7,
                     seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYKLLVLDVDGTLLNDEKEITPRTLATLLKVQQMGVHIVLASGR
                     PTYGILPLAKKLELGNYGGYILSYNGAQVINAKNGEVLLERRINPEMLPYLEKKARKNG
                     FAIFTYTEDRMIADQADNEHILQEAFLNRMELIEEPEFSVAVDFAPSKCMLVSDDEEAL
                     IGLEEHWKKRLNGALDVFRSEPYFLEVLPCGIDKSTSLGALLSHLDITPEEIIVIGDGV
                     CDVSMIQFAGLGIAMGNAQDSVKVCADVVTASNEEDGVALAVEKAILSEIRPAEIPLDQ
                     LNERARHALMGNLGIQYTYASEDRVEATMPVDERTRQPFGILHGGATLALAETVAGLGS
                     MILCQPDEIVVGMQVSGNHMSSAHEGDTVRAVGTIIHKGRSSHVWNVDVFTSTDKLVSS
                     IRVVNSILKKR"
     CDS             1647..2753
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Chorismate_bind"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg170_3"
                     /sec_met_domain="Chorismate_bind (E-value: 8.4e-54,
                     bitscore: 174.0, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLEETNNCEIIDELIRQGRSFAMYRNPGEEEPHFLMQTCGEVHL
                     IRKMEDLNGRTGFVIAPFRVTPQCPIILIRPDCHEIPSCAGNLHTPAQGDDAASYGQQL
                     RSDWSLGAKKAYEACFDVFIRALRERTFDKLVLSRRMTVRREPGFSPAAAFYRACRRYI
                     YSYVYLCYTPQTGVWMGSTPEIILSGEKGEWNTVALAGTQSLQNGELPQQWDEKNREEQ
                     EYVAAYIRKQLRSLGISPTEKGPYPAFAGALSHLKTDFHFSLNDSQRLGDLLKLLHPPP
                     AVCGLPKEEAYRFILDNEGYDRSYYSGFIGWLRPEGRTDLYVNLRCMNVKEDSLTLYAG
                     GGLLASSELDDEFQETEKKMQTMQNLNS"
     CDS             2774..4441
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg170_4"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1e-07, bitscore:
                     23.1, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYSDKKNILQLVALLRAHGVTKVVLCPGSRNAPIVHTLAGHPDFT
                     CYSVTDERSAGFFAIGLALQGGTPAAVCCTSGTALLNLHPAIAEAYYQKVSLVVISADR
                     PAAWINQMDGQTLPQPGVFRSLVKKSVDLPEIHTDEDEWYCNRLLNEALLELNHHGKGP
                     VHINVPVSEPLFQFTAESLPEVRVITRYQGLNVYDRDYDGLIDRLNKYNRRMMIVGQMN
                     LIYLFEKKYSKMLYKQFAWFTEHLGNQTVPGIPIRNFDAALYAMSPEMQEKMIPELVIT
                     YGGHIVSKRMKKYLRQHPPKEHWHVSPDGEVIDLFQGALTTIIEMDPFEFMEKIAFLLD
                     NRTPEYPRQWENFCKELPRPELPYSEMSAIGSLIQALPASCALHLANSSAVRYAQLYSL
                     PDTVEVCCNRGTSGIEGSLSTAIGYAAASKKLNFVVIGDLSFFYDMNALWNNHFGSNLR
                     ILLLNNGGGEIFHTLPGLEMSGTSHRFVTAVHKTSAKGWAEERGFLYQEVQDEKQLDEA
                     MKTFTQPELLTQPVIMEVFTNKNKDARILKDYYHQLKN"
     CDS             4443..5447
                     /locus_tag="ctg170_5"
                     /transl_table=11
                     /translation="MMTKHKMNLFCGMLLLSASLFVEKAQAMFPERYVSEESAARADTI
                     NFRLASAGEAKRLIAAKDSYTANWSPFDIAARLENPEGKREDLVSLAVREVREWTAEEA
                     QQIEQIRKNLNDTIRKYGYRIPFPKEIVLVKTTMKDEGGAGGYTRSNWIALTDATFQRG
                     TEVSHTRLLVHETFHILTRLNPGFKKKLYRAIDFNILPKEIEFPEDIRKSRISNPDVSR
                     CDSYATFTIDGKPQNCTMIIYTNRPYTTGKFYQYINVGLIPLDESFKPLRESGKTVIYP
                     LQKATDFFDKVGRNTGYVIDPEEVLADNFAIALLNTPNVHTPELQKKVQELLK"
     CDS             5469..6293
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: ECH_1"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg170_6"
                     /sec_met_domain="ECH_1 (E-value: 8.3e-83, bitscore: 268.7,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="METKREWTPIKEYEDILFDYYNGIARITINRERYRNAFTPTTTGE
                     MSDAMRICREEPDINVVVLTGAGDKAFCSGGDQNVKGRGGYIGKDGVPRLSVLDVQKQI
                     RSIPKPVIAAVNGFAIGGGHVLHVVCDLSIASENAIFGQTGPRVGSFDAGFGSSYLARV
                     VGQKKAREIWFLCRKYNAQEALDMGLVNKVVPLDKLEDEYVQWAEEMMQLSPLALRMIK
                     AGLNAELDGQAGIQELAGDATLLYYLTDEAQEGKNAFLEKRKPDFKQYPKFP"
     CDS             6516..7361
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MR_MLE_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg170_7"
                     /sec_met_domain="MR_MLE_C (E-value: 1.9e-30, bitscore:
                     97.3, seeds: 401, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LPDYEQVLRSACQRLEQTGELDIESLRGYPSILFGLETALRHYET
                     QSWALWDTPFSRGEVGIPINGLIWMGSFDRMLQQIEVKMQAGYRCIKLKIGAINFEEEL
                     ALLRHIRAHYSAREIELRVDANGAFSPADAMDKLNRLAELDLHSIEQPIRAGQWEEMAR
                     LAAESPLPIALDEELIGCNALERKRELLAAIHPRYIILKPSLHGGISGGNEWIAEAEKQ
                     HIGWWITSALESNIGLNAIAQWCATFRNPLPQGLGTGLLFTDNVEMPLEIRKDCLWFCK
                     "
     CDS             7375..8469
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025:AMP-binding enzyme (Score: 60.1; E-value:
                     4.9e-19)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg170_8"
                     /sec_met_domain="AMP-binding (E-value: 2.8e-19, bitscore:
                     60.1, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIFNREEQHLMLEGSVLSKEDVKRLVACHTEEASGFLYELYRFLE
                     EWFSDSPYLTVKTSGSTGTPKLLKVRKEQMMQSARLTCEFLGLRQGDSVLLCMPLQYIA
                     GKMVVVRALVAGLNLVIRTPSGHPMADVDIPLRFAAMVPLQVYNTLQVSAEKERLCRTD
                     ILIIGGGAIDAGLEAEIRQLPVKVYSTYGMTETLSHIALRRLNGPDASMLYRPFPSVRL
                     SLSSEHTLVIDAPLVCDTTLVTNDVAEIYPDGSFSILGRKDNTINTGGIKVQAEQIEEI
                     LRPWMRVPFAITSVPDARLGEAVVLLVEKGADAELPETKMKELLSKYQLPKMILSVGAI
                     PLTETGKINRAACRQLALTYRTDR"
     CDS             8540..9397
                     /locus_tag="ctg170_9"
                     /transl_table=11
                     /translation="MNKICFFIGVFITLLLAGCSSNPISHVRVATFNIRYDNPGDSLNS
                     WKYRKEKVCEFIREKHPDVLGMQEVLNHQLKDLLSGLPDYAYVGVGREDGKTQGEYAPV
                     FYRKDKYDLLDSNTFWLSEHPDSIGKLGWDAACTRVATWAKLKDKTTGKEFLMLNTHFD
                     HVGTEARRNSALLIIDKIKEIAGTHPAMMTGDFNVSEEWEAYKTITSNEFVLKDAWKIA
                     GKQSGENYTFHDFGRVPVAEREKIDFIFVTPQIKVADAEIISSAITDSTYLSDHNAHLA
                     DLEF"
     CDS             9420..11435
                     /locus_tag="ctg170_10"
                     /transl_table=11
                     /translation="MKQILHILLIALMLMGFYSCVPKTELASPDGHIKVAFTADTDGKM
                     MYRVTVNDTLLLDNSPLGFEAKDGIDLNRGFRVVSTVFTDKDEIWTQPWGENKTNRNHY
                     NEMAVLLKNAANVELTLRFRAFDDGVAFRYEYEVPGVDSLLITDELTAFRFHEDGTSWS
                     IPASFETYELLYSKQKISEVENANTPFTFKTSGGVYGSIHEAALYDFPEMTLKKDGENT
                     LKSELASWPDGIKARKENRFTTAWRTIQIAPQAVGLINSSLILNLNEPCKLDTTDWIKP
                     MKYVGVWWGMHLGVETWKMDDRHGATTANAKKYIDFAHANNIEGVLFEGWNEGWESWGG
                     MQSFDFTKPYADFDMDEITRYAREKNVQIIGHHETGGNIPNYERQMEKAIKWYTDKGIH
                     ILKTGYAGAFPDGHSHHGQYGVNHYQKVVETAARYRMTLDAHEPIKDTGIRRTWPNMMT
                     REGARGMEWNAWSEGNPPSHHEMLPFTRLLGGPMDYTPGTFDILFTQTKDSPKRQKWND
                     QDKGNSRVNTTLAKQLANWVILYSPLQMASDMIEHYEGHPAFRFFRDFDPDCDESRALA
                     GEPGEFVAVVRKAKQNYFLGASTNEEPRVLPVSLDFLEKGKTYKAIIYADGEKADWKTN
                     PTEYQITEQEVTADDTLNIRMAAGGGQAISFMPLQK"
     CDS             complement(11412..12011)
                     /locus_tag="ctg170_11"
                     /transl_table=11
                     /translation="MAQTLTNLNINDNNAVISALREGDEEVFDHIYRYYFRGLCAFCSQ
                     YVTLSESEEIVQDTMMWLWENRKTLIPELTLKTLLFTIVKNKALNKISHFEIKRKVHQE
                     IAEKYETEFSSPDFYLENELFRLYEEALRKLPAEFRQAYEMNRSLQMTHKEIAEKLNVS
                     PQTINYRIGQALKILRSELKDYLPLIMLFLFLQGHK"
     CDS             12177..12803
                     /locus_tag="ctg170_12"
                     /transl_table=11
                     /translation="MDETKLLNYLKGESDAEECLEVEAWYHASAEHKKQLDQLYYMLFV
                     GERKVAMDGVDTENSLSVLKDRIKQKESEKKSVHRIRVSKWKRYAMPLAAFLCGLLVSA
                     GALYWISSGKSAGYVFATESGQRAQAVLPDGTKVWLNASTQIVYKPSFWKRERQVDLSG
                     EAYFEVSRNKTKPFVVNSNDVRTCVLGTKFNVRARPSEEKVVTTY"
     CDS             12800..13186
                     /locus_tag="ctg170_13"
                     /transl_table=11
                     /translation="LKGSVKVQLPGQSEEEGILLKPGQMLSVDTRTMQPMLTEANRPGD
                     VLLWINGKLKFEQATLQEIVQCLEKHFDVHFIISDAQLQKDRFTCTFSTDDDIRQILSI
                     LALTKRFDYKCEDNNIILTPKTNR"
ORIGIN
        1 taccaaggag cagaaatcag acaataggaa aaaatccaag acacgttgcc ttgtcgagca
       61 tgtattcggg tttgaggaac aaaccatgcg tggacttgtg gtgcgtacag tagggcttat
      121 tcgtgctaaa gccaatgtag cactcaccag tcttgtgtat aacatcagtc gttacacgca
      181 aataatcagg ctgaaacctg agttgttggg gtgaattatg cctgcacatc caatttttac
      241 aacaaacaca agttaattat tgtaaaaatt gggggggggt agaaaatatt cgctaaattt
      301 gaaagactaa agctcacaaa ttgggcagtt aaagagttct gctgtctgat acaagaggat
      361 aaattgaatt gatagaactc accttacctt tgtaatctaa acaaaaaact cgaggtcatg
      421 aagtataaac tgttagtcct tgatgtagac gggacattgc tcaatgatga gaaggagatt
      481 actcctcgta cccttgccac tttgttaaaa gtacagcaga tgggagtaca tattgttttg
      541 gcctccggtc ggcccactta tgggattttg cctttggcaa agaaactgga gctgggtaac
      601 tatggcggat acatcctgtc ctataacggc gcacaggtca ttaatgccaa aaatggggaa
      661 gtattgctcg aacggcgtat taaccccgaa atgttgcctt atctggagaa gaaagcccgt
      721 aaaaacggat ttgcaatctt tacttacacc gaagaccgaa tgattgctga tcaggcagat
      781 aatgaacaca ttcttcagga agcattcctc aatcggatgg agttgattga agaacccgaa
      841 ttttcggttg ccgttgattt tgctccttcc aaatgtatgt tggtcagtga tgacgaagag
      901 gcgcttatcg gattggaaga acattggaaa aaacgtttga acggagcgct cgatgtattc
      961 cggtcggaac cctatttcct ggaagtcctg ccatgtggca ttgacaaatc aacttcgttg
     1021 ggagccttgc tttcccattt ggatatcact ccggaagaaa tcattgttat cggtgatggc
     1081 gtttgcgatg tttccatgat ccagtttgcc ggattgggta tcgccatggg caatgctcag
     1141 gattcggtaa aggtatgtgc cgatgtggtg acggcttcga atgaagaaga cggagttgct
     1201 cttgccgtag aaaaagcgat tctttctgag attcgtccgg cagagattcc tctcgaccaa
     1261 ttgaacgagc gtgcacgtca tgccttgatg ggaaatctgg gcattcaata tacctatgct
     1321 tccgaagacc gggtagaggc tactatgccg gtagacgagc ggacccgtca gcctttcggc
     1381 attctgcacg gaggtgccac gttggcactg gccgagactg ttgccggact gggttcgatg
     1441 attctctgcc agcccgacga gattgtggtt ggtatgcagg tcagcggtaa ccacatgtca
     1501 tctgcccacg agggagatac cgtacgtgcc gtcggtacca ttatccacaa aggacgttca
     1561 tcacatgtct ggaatgtaga cgtatttacg tcgacggaca agttggtgtc ttccatacgg
     1621 gtagtgaata gtatattaaa gaagagatga cgttagaaga aacaaataat tgtgagatta
     1681 tagatgaatt gatccgtcag ggaaggagct tcgcaatgta tcgtaatccg ggcgaagagg
     1741 aacctcactt tctgatgcag acttgcggag aagtacacct tatccggaaa atggaagatt
     1801 tgaatggtcg gacaggcttt gtcatcgccc ctttccgggt cactccgcaa tgtcctatca
     1861 tattgatccg gccggattgt catgagattc cttcctgcgc cggaaacttg catacccctg
     1921 cacaggggga cgatgcggca tcgtacgggc aacagctccg aagcgactgg tcactcgggg
     1981 cgaagaaagc ctatgaggct tgtttcgatg tctttatcag ggctttgagg gaacgtactt
     2041 ttgataagtt ggtactatcc cgcagaatga cggtgaggag agagccggga ttctctcccg
     2101 cagcggcttt ctaccgggct tgcaggcgtt acatctattc gtatgtctat ctttgctata
     2161 ctccgcaaac cggggtgtgg atgggcagta ctccggaaat cattttatcg ggtgagaaag
     2221 gagaatggaa tacggtagcg ttggcaggaa cccagtcttt acagaatggt gagcttccgc
     2281 aacaatggga tgaaaagaac cgggaggagc aggagtatgt ggcggcatat attcgtaaac
     2341 aactccgctc gttggggatt tctccgacgg agaaaggacc ttatccggct tttgccgggg
     2401 cattgtctca cctgaaaacg gatttccact tctcgctgaa cgacagtcag aggttgggag
     2461 atttattgaa gctgttgcat ccccctcccg ccgtatgcgg attgccaaaa gaagaagctt
     2521 accggtttat ccttgacaat gaaggctatg accgcagcta ttattccgga tttataggct
     2581 ggttgaggcc ggaagggaga acggacctgt atgtcaactt acgctgtatg aatgtgaaag
     2641 aagattcgtt gacattgtat gccggaggcg gcctgctggc ctcttccgaa ttggatgatg
     2701 agtttcagga gacggaaaag aagatgcaga ccatgcagaa cttgaactcc taaataaaat
     2761 aatatataaa gcgatgtatt cagataagaa aaacatattg cagttggtag cgttgctccg
     2821 tgcacatggg gtgacgaaag tcgttttatg tcccggaagc cggaatgcac cgattgtaca
     2881 tacacttgcc ggacatcccg acttcacttg ttactcggta acagacgagc ggagtgccgg
     2941 cttttttgct atcgggcttg ctttacaggg cggaactcct gccgctgttt gttgcacatc
     3001 gggcacggct ttgttgaatt tgcatcctgc catagcagag gcctactacc agaaagtatc
     3061 tttagtagtt atttccgccg atcgtcctgc cgcctggatc aaccagatgg acggacagac
     3121 tttacctcag ccgggtgttt tccggtcatt ggtgaagaag tctgtcgatc tgcccgaaat
     3181 acatacggac gaggatgaat ggtactgcaa ccgcttgctg aacgaagcat tgcttgaact
     3241 gaatcatcat ggtaaaggcc ctgtgcacat caacgtgccg gtttccgaac ccctgttcca
     3301 gtttacggca gagtcacttc ccgaagtacg tgtcatcaca cgttatcaag gactgaatgt
     3361 ttatgatcgc gactatgacg gcttgatcga ccgcctcaat aaatacaacc gccgtatgat
     3421 gatcgtcggc cagatgaacc tgatttatct gttcgaaaag aaatattcaa agatgctcta
     3481 caagcagttt gcctggttca cggagcattt aggcaatcag accgttccgg gcatcccgat
     3541 ccggaacttc gatgcagccc tctatgccat gtcacccgag atgcaagaga agatgattcc
     3601 cgaattggtg atcacttacg gggggcatat cgtctctaaa cgaatgaaaa agtatcttcg
     3661 ccagcatccg cccaaagagc attggcatgt gtcgccggat ggtgaagtga tcgatctgtt
     3721 ccaaggggca ttgactacga ttatcgagat ggacccattt gaatttatgg agaagatagc
     3781 ttttctgctg gataaccgta caccggaata tccccggcaa tgggagaact tctgcaagga
     3841 gcttccccga ccggagttgc cttattccga aatgtctgct atcggatcac tcattcaggc
     3901 gttgcctgct tcgtgtgctt tgcatctggc caatagttcc gccgtgcgtt atgcccagct
     3961 ttattcgctt cccgatacgg tagaggtttg ttgcaaccgg ggtacgagcg gcattgaagg
     4021 ttccctttcc acagcgatcg gttatgctgc cgcttcgaag aagttgaact ttgtggtcat
     4081 tggtgatctg agctttttct atgatatgaa tgccctgtgg aacaatcatt ttggaagtaa
     4141 cctccgtatt ctgcttttga ataatggggg aggggagatt tttcatactt tgccgggact
     4201 tgaaatgtcc ggtacttccc atcgctttgt gactgccgtg cataagacgt ctgccaaggg
     4261 atgggccgaa gaacggggat tcctctatca ggaagtgcag gatgaaaaac agttggacga
     4321 agccatgaaa actttcactc aacccgagtt actgactcaa cctgtcatta tggaggtttt
     4381 caccaataaa aataaagatg cacggatatt gaaagactac tatcaccaac taaaaaacta
     4441 atatgatgac taagcacaag atgaacctat tttgtgggat gctacttttg tcagcttccc
     4501 tgtttgtgga gaaagctcaa gccatgtttc ccgagagata cgtatcggag gaatcggcag
     4561 ccagggcaga tacaatcaat tttcggttgg cttctgccgg agaagcaaaa cgcctgatag
     4621 cggccaaaga ttcttatacg gctaattgga gtccgtttga catcgctgcc cgacttgaaa
     4681 atcctgaagg caaaagagaa gacctcgtca gcctggccgt tcgtgaagtg cgtgaatgga
     4741 cagcggaaga agcgcagcag atcgagcaga tcaggaagaa cctgaatgat acgattcgta
     4801 aatacggcta tcggattcca tttccgaaag agattgtgct ggtaaagaca acaatgaaag
     4861 acgaaggagg ggcgggagga tacacacgca gtaactggat cgcattgacg gacgctactt
     4921 ttcagcgggg gaccgaagtt tctcacacac gcctgctggt gcatgaaact ttccacatcc
     4981 tgacacgtct caatcccgga ttcaaaaaga aactgtacag agctatcgac ttcaacatcc
     5041 tgcccaaaga gattgagttc cccgaagata tacggaaaag ccgtatctcc aatcccgatg
     5101 tcagtcgttg cgatagttat gcgactttta ccattgacgg taagccacag aactgcacta
     5161 tgattatcta taccaacaga ccctatacca cgggtaagtt ctatcagtat atcaatgtgg
     5221 ggctgattcc gttggacgag tcgttcaagc ctctccggga gagtgggaag acagtgattt
     5281 atccattaca gaaagcgacc gacttctttg ataaagtagg gcggaacacc ggatatgtca
     5341 tagatccgga agaggtactg gcggataatt ttgcaattgc tttattgaac acgcccaatg
     5401 tacatacacc cgaactgcaa aagaaagtac aggaattact gaaataataa tcatcaaaat
     5461 aaatagaaat ggaaactaaa agagaatgga ctcctattaa agaatacgaa gatattctgt
     5521 ttgattacta taacggcatt gcccgtatta cgatcaatcg cgaacgttac cggaatgctt
     5581 tcacccctac tacaacaggc gaaatgagcg atgcgatgcg catctgtcgt gaagagcccg
     5641 atatcaatgt tgtggtattg accggtgcag gcgataaggc cttctgttcg ggaggcgacc
     5701 agaacgtaaa gggccgtggc ggatacatcg gtaaagacgg agtgccccgc ctgagtgtat
     5761 tggatgtgca aaaacaaatc cgttcgattc cgaaaccggt tattgctgcc gttaacggat
     5821 ttgccatcgg aggcggacac gtgttgcatg tcgtatgcga tctctctatt gcttccgaaa
     5881 atgcgatctt cggacagaca ggtcctcgtg taggtagttt cgatgccggc ttcggatcat
     5941 cttatcttgc ccgcgttgtg gggcagaaga aggcccgtga gatctggttc ctttgtcgca
     6001 agtataatgc gcaggaggct ctggatatgg ggctggtcaa taaagtggta ccgctggata
     6061 aactggaaga cgagtatgtt cagtgggcgg aggagatgat gcagcttagt ccgttagcac
     6121 tccgcatgat taaagccggt ctgaatgccg aactcgacgg tcaagccggt attcaggaac
     6181 tggcaggtga tgccactctg ctttattacc ttaccgatga agcacaggaa ggcaagaatg
     6241 cttttctgga gaagcgtaaa ccggacttta aacaatatcc taaatttcca taagcagaca
     6301 gaggccttct tgatgggagg ccttttcttt atatcatttt tatgtataca atcaacatta
     6361 ttccacgcgt tcttcatttc aagcaacctg cgggaacttc gcgtggttct tatactaccc
     6421 ggaatgtctg gtatatccat ctttcttcca tagagtgtcc gggacgtgtc ggagtaggag
     6481 agtgtgctcc gttacccaaa ctgagttgtg atgacttgcc ggattatgaa caggtgcttc
     6541 ggagtgcctg tcagcgactg gaacaaacgg gagaactgga tatagaatct ttacgtgggt
     6601 atccttctat tctgttcgga ctcgagacag cactgcgcca ttacgaaaca cagagctggg
     6661 cattatggga tactcctttt tcgcgcggag aagtcggtat acctattaac ggacttatct
     6721 ggatgggaag ttttgacaga atgctgcaac agatcgaagt caagatgcag gcgggatatc
     6781 gctgtatcaa actaaaaatc ggtgcgataa actttgaaga agaattagcc ctgttgagac
     6841 atatccgtgc tcactattcc gccagagaaa tagagttgag agtggatgcc aatggagctt
     6901 tctcacctgc cgatgctatg gataaactga atcggttggc cgaattggac ctacattcca
     6961 tagaacagcc tatccgggcc gggcagtggg aggaaatggc ccgtctggcg gctgagtccc
     7021 cgcttcctat tgctttggac gaagaactga taggttgcaa tgcccttgaa agaaaacggg
     7081 aattgctggc ggctatccac ccccggtata tcatactgaa accatctctg catggcggga
     7141 tcagtggtgg caacgaatgg attgcagaag cggaaaagca acatatcggt tggtggatca
     7201 catctgcgct ggagtcgaat atcggtctga atgccatagc ccaatggtgt gcgactttcc
     7261 ggaatccgtt gccacaagga ttaggtaccg ggctactgtt tacggacaat gtcgagatgc
     7321 ccctcgagat tcgaaaagat tgtttatggt tttgcaaata agaggagtcg gcacatgata
     7381 tttaatagag aagaacaaca cctaatgttg gaaggcagtg tgctttccaa ggaggacgtg
     7441 aaaaggctgg tggcttgtca cacggaggag gcatcgggat ttttgtacga actttaccga
     7501 tttctggaag agtggttcag tgattctcct tatctgacag tgaaaacttc cggttctact
     7561 gggactccca aactgctgaa ggtccgtaag gagcagatga tgcaaagtgc ccggctgact
     7621 tgtgagtttc tgggacttcg acaaggagat agcgtattgt tgtgtatgcc tttgcaatat
     7681 attgccggga agatggtggt ggtccgggca ttggtggcag ggttgaatct ggttatccgg
     7741 actccttccg ggcatccgat ggcggacgtg gacataccgc ttcgctttgc cgctatggtg
     7801 ccgttgcagg tttacaacac actgcaggta tcggcagaaa aagagaggct ctgccggacc
     7861 gatattctta ttataggcgg aggggcaata gatgcagggt tggaagctga aatacggcaa
     7921 ttaccggtta aggtttattc tacgtatggc atgacagaaa ccctttcaca tattgcttta
     7981 agacggttga acggaccgga tgcgagtatg ttgtaccggc cttttccttc ggtacggctt
     8041 tctctttcgt ccgaacatac attggtgatc gatgctccat tggtttgtga taccactttg
     8101 gtgacaaatg atgttgcgga gatttatccc gatggcagct tctctatttt gggcaggaag
     8161 gataatacca tcaataccgg aggtatcaaa gtacaggcag agcagataga agagatactt
     8221 cgtccctgga tgagagttcc ttttgcaatc acttctgttc ccgatgccag attaggagag
     8281 gcggttgtgc ttttggtaga gaagggggca gatgcagagt taccggaaac aaagatgaag
     8341 gagcttctgt ccaaatatca gttacccaag atgattttgt cagtcggggc tatacccttg
     8401 acggaaacgg gaaagatcaa tcgtgccgct tgccggcaac ttgccctcac ttatcggaca
     8461 gatcgctaag tgttttttct tctttagttg tatcatatac gaaatagctt taaatttaat
     8521 aaccaacaca tataaactaa tgaataagat ttgctttttt atcggagttt ttattaccct
     8581 gcttttggcg ggttgcagtt ctaatccgat ttcccatgtt cgtgtggcga cctttaatat
     8641 ccgctatgat aatccgggcg acagtttgaa ttcctggaag tatcgtaaag agaaggtctg
     8701 tgaatttatc cgtgagaaac atcccgatgt gctgggaatg caggaagtac tgaatcatca
     8761 gttgaaagac ctgttgtccg gcctgcccga ttatgcctat gtaggtgtgg gacgcgagga
     8821 tggaaagact cagggggaat atgctcctgt attctatcgg aaagataaat atgatttgtt
     8881 agacagtaat acattctggc tttccgaaca tccggatagt atcggcaaac ttggttggga
     8941 tgccgcatgt acccgcgtgg ctacttgggc taaattaaag gataaaacta ccggaaaaga
     9001 gtttctgatg ttaaacaccc attttgacca cgttggtacg gaagctcgtc gtaacagtgc
     9061 cctgcttatt attgataaga taaaagaaat agccggtacg catcctgcta tgatgaccgg
     9121 agactttaat gtttctgaag agtgggaagc ttacaaaacg atcacatcca atgagtttgt
     9181 cttgaaagat gcatggaaga tagccgggaa acagtccggt gagaactaca ctttccatga
     9241 tttcggaaga gtacctgtgg ccgaacggga aaagatcgat ttcattttcg taactccgca
     9301 aatcaaggtg gcagatgcag agattatttc ttctgcgatt acagattcca cctatttgtc
     9361 cgatcataat gcacatctgg ctgatttgga attctaaacc gtataaacga attgtaacca
     9421 tgaaacagat tttgcatata ttactcatcg ccttgatgct gatgggcttt tatagttgtg
     9481 ttccgaagac ggaattagcc tctccggacg gacatatcaa agtggctttt actgcggata
     9541 ccgatggaaa gatgatgtat cgggtgactg tcaacgatac ccttttattg gataactctc
     9601 cgctcggttt cgaagcgaaa gacggaatcg atcttaatcg gggatttcgt gtggtgagca
     9661 ctgtctttac cgataaagac gagatctgga cgcagccttg gggagagaat aaaacgaacc
     9721 ggaatcatta taatgaaatg gcggttcttc tgaaaaatgc cgctaatgtg gaattgactc
     9781 ttcgttttcg tgcatttgat gatggtgtag cctttcgtta cgagtatgag gtgcccggtg
     9841 tcgactcttt gttgatcacc gatgaactga ctgctttccg ctttcatgaa gacgggacct
     9901 cttggtctat tcctgccagt ttcgagactt atgaattgct gtactcgaaa cagaagatca
     9961 gtgaagtgga gaatgccaat actcctttca ctttcaaaac atccggaggg gtgtatggca
    10021 gcattcatga agccgctctt tatgattttc cggaaatgac tttgaagaag gatggtgaaa
    10081 atactctgaa atccgaactt gcctcatggc ccgatggaat taaagctcgt aaagagaatc
    10141 gttttaccac tgcatggcgt accattcaga ttgctccgca agctgtcgga ctgattaatt
    10201 cgtcgttgat ccttaacctg aatgaacctt gtaaactgga taccaccgac tggatcaagc
    10261 cgatgaaata tgtcggtgtc tggtggggga tgcatctggg agtggaaacc tggaagatgg
    10321 acgatcggca tggcgctaca accgccaatg ccaagaaata cattgatttt gctcatgcca
    10381 ataacatcga aggtgtgttg tttgaggggt ggaatgaagg atgggaaagt tggggaggta
    10441 tgcagagttt tgactttact aaaccttatg ccgactttga tatggatgaa ataactcgtt
    10501 atgcacgtga aaagaatgtt cagatcatcg gacatcatga aaccggtgga aacattccca
    10561 actacgagcg ccagatggag aaggcaatca agtggtatac cgataagggc attcatattc
    10621 tgaaaacagg ttatgccggt gcttttcctg acggacattc acatcatgga caatatggag
    10681 tgaaccatta tcaaaaagtg gttgagacgg ctgcccgtta tcgtatgact cttgatgcgc
    10741 acgaacctat caaagatacc ggtatacgac gtacctggcc caatatgatg acacgtgaag
    10801 gcgctcgcgg tatggagtgg aatgcctgga gcgagggtaa tcctccttca catcatgaaa
    10861 tgttgccgtt tacccgctta ttgggtggtc cgatggacta tactccgggt acttttgata
    10921 ttttgtttac acagacgaaa gattctccta aacgtcagaa gtggaatgat caggataagg
    10981 gcaatagtcg cgtcaataca acattggcca agcagttggc taattgggtg attttatatt
    11041 ctccgttaca aatggcatct gatatgatcg agcactatga agggcatcct gccttccggt
    11101 tcttccgtga tttcgatcct gattgtgacg aatcgagggc attggccggt gagccgggag
    11161 agtttgtagc agtggtacgg aaggctaaac agaattattt cctgggtgcc tctacgaacg
    11221 aagaaccgcg ggtcttgcct gtcagtcttg attttttaga gaaggggaag acttataaag
    11281 caatcatcta tgctgatggt gagaaagctg attggaaaac caatccgaca gagtatcaga
    11341 ttacggaaca ggaggtgact gcagacgata cgttgaatat ccgtatggca gccggtggcg
    11401 gacaagctat ttcatttatg cccttgcaga aataaaaaca acatgatcag cgggagataa
    11461 tcctttagtt cggaccgtaa tattttcagg gcttgcccta tgcgataatt gattgtttgc
    11521 ggagagacgt tcagtttctc cgcaatttct ttatgagtca tttgaagact tcgattcatt
    11581 tcgtatgcct ggcgaaattc ggccggtagt tttcttaaag cctcttcgta caatctgaat
    11641 agttcgtttt ccaggtaaaa gtcaggtgaa gagaactccg tttcatattt ttccgcaatt
    11701 tcctgatgca ccttgcgttt tatttcaaaa tgagagattt tattaagcgc tttgttcttg
    11761 acgatagtaa agagaagagt ctttaaagta agttccggta taagggtttt tctgttttcc
    11821 catagccaca tcatagtatc ctgcacgatt tcttccgatt cgctcagagt gacatattga
    11881 gagcaaaagg cgcataatcc acgaaaatag taacggtaga tatgatcaaa cacctcttca
    11941 tccccttctc gcagggctga tataacggca ttattatcat ttatgtttag gttagtcaga
    12001 gtctgtgcca ttcttctctc cattgttatt agcgaacaaa cgtagctaaa tttttgctac
    12061 ctgcaaaatg attttctgaa gaaaaaaaag tttgtgtttt atttagtaac tttgttttct
    12121 gaactgtatt atacgtaaca gtgtatgata taggtattaa agatttggtt aaaacaatgg
    12181 atgaaacaaa actactgaac tatctgaaag gagaatcaga tgccgaagag tgtctggaag
    12241 tggaggcatg gtatcatgct tctgcagaac acaaaaaaca actggaccaa ctttattata
    12301 tgctttttgt cggtgaacgt aaggtggcaa tggatggtgt ggacaccgaa aattcactaa
    12361 gcgttttgaa ggaccggata aagcaaaaag agtcagagaa aaaatcagtg catagaatac
    12421 gtgtatcaaa atggaaacgt tacgcgatgc ctttggcagc tttcctgtgc ggtctgttgg
    12481 tgtctgccgg tgccctatac tggatttcct ccggaaagtc ggcaggatat gtttttgcta
    12541 ccgaatcagg gcagcgggca caggcagttt taccggatgg aacgaaagta tggttgaatg
    12601 cttcaacaca gatcgtctat aagccttctt tctggaagcg ggaaagacag gtcgacttga
    12661 gtggtgaggc ttattttgag gtatcacgta ataagacaaa accctttgtt gttaatagta
    12721 atgatgtcag gacttgcgtg ctcggtacaa aattcaatgt ccgggcacgt ccgtccgaag
    12781 aaaaggtggt gaccacttat tgaagggatc agtaaaagtc caattgccgg ggcagtctga
    12841 agaggaaggt attttgttga agccgggaca gatgctgagt gtggataccc gtacgatgca
    12901 acccatgctt acagaagcca accgtccggg agatgtattg ctatggatta acggaaaact
    12961 gaaattcgaa caggccacac ttcaggaaat agtgcagtgt cttgaaaaac attttgatgt
    13021 tcatttcatt atttcggatg cacaactgca aaaagaccgt tttacctgta cttttagtac
    13081 ggacgatgat ataagacaaa ttctttctat actcgctctt accaaacgtt tcgattataa
    13141 atgtgaggat aacaatataa tattgactcc taagacgaat agataacaaa aatattttat
    13201 aacctaaatc acgaagaggg ggctgtttct gtaaagaaat agttcccttt ttttatcttc
    13261 tgatctgtat tcttattctt tttttattct tttttcgaaa aaatccgctt cttgatttag
    13321 tatgtttata agttgaaatg tactattaac agaaaagaga tatagttaac ctaaaaatct
    13381 gtagtgatga ataatgaccc ttaatttgaa accaacctta acatgtatta gcgatccttt
    13441 atgctaaacc tttcaatttt acctaaaaac attttctaat taaaaaaaga acaagatgaa
    13501 gaaatcagtg aaacacaagt ttcagtactt gctatttttt ctattgtcga tgcctgcttt
    13561 tatctttgct tcagcgcaag atatacgggt gaatatcgac tttaccaaag cctctttggg
    13621 cagtgtcctg aatgaaatag gacgtcaaac ctcattatct attgtgtata acaccgggga
    13681 tgttaacccc actcaacctg tttctatcaa ggcttctaac gaaaatatca cgacggtcat
    13741 gaaccgtctg cttcgtggga cgggactttc ctattctatt atgaacaaac atcttattct
    13801 ttcgaccact gataagaacc attcgattca acaggagaaa gttacggtta cgggaaatat
    13861 ttcggatgcc aaaggcgaac cactgatcgg agtgagtatt ctggtgaaag gaacatcgaa
    13921 cgggacaatt accgatatga acgggcactt ctccttgccg gttgcgaaag gagatgttat
    13981 tgagatctcc tatatcggtt atgctccgca ggccattacg gtgacagact ccaagccttt
    14041 gaagattgtt atgaaagaag acgcagaagt gcttgacgaa gtggtagtga ctgccttagg
    14101 tatcaagcgg gcgcaaaagg cgttgagtta caacgtacag caagtaggtg gtgatgctat
    14161 caatacagtg aaggatgcca attttatcaa ctctttgcaa ggtaaagttg ccggagtaac
    14221 aatcaataac tcagccggtg gagttggttc tgcttcgaga gtcgtgatgc gcggtaccaa
    14281 gtccattacg aaagataata atgctcttta tgtaattgac ggtattccga tgttcaatgt
    14341 aagctttggt aagagtgaag gttcttttgc cacccaaagc ggttcggacg gagtagcgga
    14401 tcttaacccg gatgatattg aaagtatcaa tatgctgacc ggtccttctg cggcagcttt
    14461 gtatggtaat gcggctgcca atggagtcgt attgatcaat accaagaaag gatctgccga
    14521 aaagacaact ctgactgtca gcaataatac gatgttctct gacgcataca tgatgccgga
    14581 gatgcaaaac cggtatggaa acaatccggg agaatttgca agctggggca ataaaaccaa
    14641 gcaaagctat gatccttccc gtttctttaa taccggagtg aatgtaatta acgctatttc
    14701 tttttcgacc ggaacaaaga aaaaccagac ctatgcgtcg gcttcaacaa ccaatgcgac
    14761 aggtattttg cctaataaca gttatagccg ctacaatttc tctatccgga atacggccac
    14821 tttcctgaaa gataggctga ctctggatgt aggtgccagc tatatcattc agaatgacaa
    14881 gaatataacg gcacagggac aatacttcaa cccgctgccg gcactctacc tctttccccg
    14941 taacgacaat tttgaggaga tccgtatgtt cgaacgatat agcgaaagcc gtggagtgaa
    15001 cgtacagttt tggccttacg gacatcaggg attaagtttg caaaatccat attggattat
    15061 gaaacgcatg aaccgcaaga cagaaaagaa gcgctacatg attaatgcaa gcttaactta
    15121 taagctcacg gattggctca atgtagccgg acgtgtcaag gtggataatt ccgatattcg
    15181 catgactcag gaacgttatg catcgactct gactaccttt gccggtgcca atggtttcta
    15241 ttccgatcaa aatcgtacgg accgcaatac gtatgccgat atgatggtaa acattgataa
    15301 gagaataggg gacttctcgc tgaatgccaa tatcggtgcg tctatcaagg atttggttta
    15361 cgaacaaatg ggaaatgaag gtgatttggc agggatacct aacttcttta cagtgagaaa
    15421 catcaattat gaaagtaatt ataaacctaa acagttcgga tatcatgacc aatctcaggg
    15481 tgtatttgcc aatatagaat tgggatggcg gagcatggca tatctgaccc tgaccggacg
    15541 aaatgactgg gagtcccaac ttgcatttac caagcattct tcattctttt atccttccat
    15601 cggaggttct gtcgttttat ccgagatgtt ccggttgccc gagtttattt cttatgcaaa
    15661 gctacgtggc tcatacagtt ctgtggcttc atcttttgaa cgttatttat cgaatccggg
    15721 ttttgagttc aatgaacaat cccatcagtg gggatcttca accactctgc ctgccaccaa
    15781 cttgaagccg gaagataccc gttcgtggga gatcggtttg aatgccagac tgtggaatca
    15841 tttcagtata gatgccactt actatcattc gaatacctat aaccagacct ttaatatcac
    15901 tctggcatcg tcgagtggtt attcttcggc cattgtacaa acgggtaata ttcaaaacta
    15961 cggtttggag ttggcgttag gatacaataa tacatgggga gactttagct ggaacagtag
    16021 tctgacttat acgatgaatc gtaataaagt gaaacgtctt gccagcggtg ctacgaatcc
    16081 gataaccggt gaaattatcg atatgcccga actgcgtatg gctgtgctgg gtgccgacgg
    16141 atatggtccc agagttatat tgagagaggg cggaacaatg ggagacctct atgtggataa
    16201 agggttgcgt acagacggta acggtaatat ctgggtagat tctcagacag gcaaagttgg
    16261 agtgcaggat tatgccgaac cgaagaaaat tgg
//
