LOCUS       gnlProkkaKIPFAGPK_331  13778 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KIPFAGPK_331.
ACCESSION   gnlProkkaKIPFAGPK_331
VERSION     gnlProkkaKIPFAGPK_331
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-30 19:32:32
            Original ID  :: gnl|Prokka|KIPFAGPK_331
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13778
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13778
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[842:3272]"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      843..3272
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
     cand_cluster    1..13778
                     /SMILES="NC([*])C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /kind="single"
                     /product="NRPS-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13778
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS-like"
                     /region_number="1"
                     /rules="cds((PP-binding or NAD_binding_4) and (AMP-binding
                     or A-OX))"
                     /tool="antismash"
     CDS             complement(2..838)
                     /locus_tag="ctg238_1"
                     /transl_table=11
                     /translation="MQTENFTLGKKELLILLGLTLVLPFPINWALIELNPLTLMAGADD
                     VPTWIGFGGSYIGGIIGGVISIMILNKTLQQTGVLHHDLKLLQLDTIIYTQQQDWFTGF
                     KQELAENLKSIDLYVLNMVVSSISMKNYAYAKEVLTEINKGLEYQMVAASFSFTSTHLS
                     SEEKKYMNLVRRVQTEYSSFIKDILYYIPLAETISSRKKLNYDQLMDYTLSQYDYLQGQ
                     EGESTASGAIIPRVMEIDPSDDIRKELERIMEERLTGRTYLYHLKSDLAEATHQLII"
     CDS             complement(843..3272)
                     /NRPS_PKS="Domain: AMP-binding (12-401). E-value: 2.4e-83.
                     Score: 271.8. Matches aSDomain:
                     nrpspksdomains_ctg238_2_AMP-binding.1"
                     /NRPS_PKS="Domain: PP-binding (509-568). E-value: 2.7e-10.
                     Score: 32.6. Matches aSDomain:
                     nrpspksdomains_ctg238_2_PP-binding.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: PP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     261.5; E-value: 2.1e-79)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg238_2"
                     /sec_met_domain="AMP-binding (E-value: 2e-88, bitscore:
                     286.1, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 4.8e-11, bitscore:
                     32.6, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTNIQENLSRSLSTWGDKPAVVAKDGTVSYQMLERYSANIAQSI
                     RQRLSVTDPSGLRNICIGVCMERNKTLVPAILAIFRLGATYLPIDPSLPDNRKRYMAEN
                     ADMVLLLTDSSNEVGGIPSVRQLYLNGEQLSEPVVGDYTEVLPDDCAYIIYTSGTTGNP
                     KGVRISYRNLDTFTRNLIDKKLYHLSDPANRYLAFASISFDASILELMMCIPVGGTLIL
                     AGEDERRDISLLDELIRREKVNIAFFPPSLLGMFADLDFPSFKTLLFGAEAIGEKLFNR
                     LKQQPYRLMNVYGPTENTVLSTIRIVGKDTSYDDIGYPLKGTVCYVLSENLQQTTLGAT
                     GELCLGGPQVSLGYIGSVQLNEKSFISYDGERLYRTGDLVQQQPDGSIRFIGRKDTQVK
                     IRGFRIELTEIAERLNRDPDVERAHVVVVERNGRQLLGAYLQPSVSGNFHPEEVKERLR
                     AELPYYMIPDLWQVVDHFQRTINDKIDVRALPAFTSLELKYVPPVHPGEVILCGILKEM
                     LGLPQVSVEADLIDDLGLTSLDMLRLVTEANKKGCPINVSAVYTARNLRRLLLVPRQEP
                     IYWYRQQNLKKPVIILVCGSAYFNHLYFNLADRLYPKYDFLVVDAIYDHFNKVATDIPE
                     LLEYYVRTVQPMIRERTVYALTGFCMGAELAVGLAEMLHRSMGIMPKVFALDGQAWQNP
                     ALCQNYPLLVFPGDTDEMVRERNEIINIYFRTTPNLIYQGEVIVLLSGLFHQQAGLSPE
                     ESWTEENYRIFRTEYDNCERLWNKYYPNAPVLRLPADHWHFLEGESLEQLITVFLK"
     aSDomain        complement(1569..1745)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg238_2_PP-binding.1"
                     /evalue="2.70E-10"
                     /label="ctg238_2_PP-binding.1"
                     /locus_tag="ctg238_2"
                     /protein_end="568"
                     /protein_start="509"
                     /score="32.6"
                     /tool="antismash"
                     /translation="LCGILKEMLGLPQVSVEADLIDDLGLTSLDMLRLVTEANKKGCPI
                     NVSAVYTARNLRRL"
     aSModule        complement(1569..3236)
                     /complete
                     /domains="nrpspksdomains_ctg238_2_AMP-binding.1"
                     /domains="nrpspksdomains_ctg238_2_PP-binding.1"
                     /locus_tags="ctg238_2"
                     /monomer_pairings="X -> X"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(2043..2105)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg238_2_0004"
                     /evalue="1.50E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg238_2"
                     /protein_end="410"
                     /protein_start="389"
                     /score="36.2"
                     /tool="antismash"
                     /translation="FIGRKDTQVKIRGFRIELTEI"
     aSDomain        complement(2070..3236)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg238_2_AMP-binding.1"
                     /evalue="2.40E-83"
                     /label="ctg238_2_AMP-binding.1"
                     /locus_tag="ctg238_2"
                     /protein_end="401"
                     /protein_start="12"
                     /score="271.8"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="LSTWGDKPAVVAKDGTVSYQMLERYSANIAQSIRQRLSVTDPSGL
                     RNICIGVCMERNKTLVPAILAIFRLGATYLPIDPSLPDNRKRYMAENADMVLLLTDSSN
                     EVGGIPSVRQLYLNGEQLSEPVVGDYTEVLPDDCAYIIYTSGTTGNPKGVRISYRNLDT
                     FTRNLIDKKLYHLSDPANRYLAFASISFDASILELMMCIPVGGTLILAGEDERRDISLL
                     DELIRREKVNIAFFPPSLLGMFADLDFPSFKTLLFGAEAIGEKLFNRLKQQPYRLMNVY
                     GPTENTVLSTIRIVGKDTSYDDIGYPLKGTVCYVLSENLQQTTLGATGELCLGGPQVSL
                     GYIGSVQLNEKSFISYDGERLYRTGDLVQQQPDGSIRFIGRKDTQVKIR"
     CDS_motif       complement(2178..2264)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg238_2_0003"
                     /evalue="1.20E-08"
                     /label="NRPS-A_a6"
                     /locus_tag="ctg238_2"
                     /protein_end="365"
                     /protein_start="336"
                     /score="27.3"
                     /tool="antismash"
                     /translation="LGATGELCLGGPQVSLGYIGSVQLNEKSF"
     CDS_motif       complement(2766..2822)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg238_2_0002"
                     /evalue="1.50E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg238_2"
                     /protein_end="169"
                     /protein_start="150"
                     /score="26.8"
                     /tool="antismash"
                     /translation="AYIIYTSGTTGNPKGVRIS"
     CDS_motif       complement(3003..3044)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg238_2_0001"
                     /evalue="3.50E-03"
                     /label="NRPS-A_a2"
                     /locus_tag="ctg238_2"
                     /protein_end="90"
                     /protein_start="76"
                     /score="11.0"
                     /tool="antismash"
                     /translation="LAIFRLGATYLPID"
     CDS             complement(3285..5651)
                     /gene_functions="transport (smcogs)
                     SMCOG1082:TonB-dependent siderophore receptor family
                     (Score: 167.8; E-value: 9.2e-51)"
                     /gene_kind="transport"
                     /locus_tag="ctg238_3"
                     /transl_table=11
                     /translation="MKRCLLYILCCFGVVQLSAQPADNIRNSFVKAETFYKSGDIDEAC
                     RILEENLSSFQGTMHTEACRLAALCCLALDRFPEAEKYVSLLLKDEPYYYISLQDPERF
                     ADMVRKHRETKVTLVTASQQVETPEEAPVPVTLITEEMIRAIHARCLRDVLIAYVPGIS
                     GLSSNEEMNLAMRGVYSPEQENILIMQDGQRLNSYITNAVSPDYGISLAKVKQIEVLRG
                     PASSLYGSVALTAVINIVTKDGVDVRNGSISVSAGNRGQLAADLLLGKHDMNMDFMAWF
                     SLYRATGESVFVPAEKQYALYPRDGFIRLDNYSGFPAMDGGIKLQRGNLLFSFSMNYAK
                     KRQPYSMWLFSSPYSYERFRTFDGSGPGYSRWSAREQAVYSRTWQRITFSTAFYTDWNK
                     NVHYETSGDTLQDYPIFPNYDYQPIIYPTRGAFQYIRWMDFNVGFNGRVNYAYDWGKLG
                     KGNMLGGVEWNRYTLYDSEYLEGMNFKEIVRTWIEKRLYTGHEMNTDAFLQIKHNLHKN
                     WIVNAGIRYDYKRRSNKRTLQAFSPRLSLIYLRNGLNIKASYSRAFVDAPYYYRNNEMD
                     TYSGGENLQAEYLSSYQVTCAYHHSPSHIDVECNLFYNRASHFLFTQPETRVYENAGSL
                     DMGGVEVVARYKADRLSLDGNLCFQKVLNYTNFFVTDGSVNNVPGFSMNLVANYFLLKK
                     KVQSWSAHLKLNCSSHCYTQVSVLEDGLNGDATNYTVRLPGYAVFSFTTRYKYKRIEGS
                     LGIENLFNNRYECGGATVPIRQKGRWISASILYNF"
     CDS             complement(5648..6484)
                     /gene_functions="regulatory (smcogs) SMCOG1003:sensor
                     histidine kinase (Score: 141.1; E-value: 1e-42)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg238_4"
                     /transl_table=11
                     /translation="MEKNISQEKRIEELEARLKEQEKLGSLGLLSAGIAHEIQNPLNFV
                     INFSKLSGQLLADLADRVDEAKARIPEAELEDIKDILSGLRENVDKIKEHGDRAISIIR
                     GILLYSRGKEDEFMPTQIQKLTKEYVWLAYHAMRANYKNFNIAIREDYAKDIPSIRLIP
                     QDFSRAVLNVMNNACYAVWKKWQNAPEGYSPEIMVTLEKLDKRVVLSIRDNGEGMSPEV
                     KRKLFDSFFTTKPVGQGTGLGMAIVRDIIENKHHGKVLFDSVLHEYTCFRFIIPIA"
     CDS             complement(6507..9344)
                     /locus_tag="ctg238_5"
                     /transl_table=11
                     /translation="MKKIVFLIMCLCSVYANSQEGIPFFVNYPASVYQAHNRNFDVVCD
                     SCGNVYFANFEGILHYDYNRWETIYTPGFSRVTRLFRDSEGRIWVGGYNVFGRIERDGR
                     GCITLRTLLSDLDTDSLGELEDMAEIDKRIYLKATSGRYYTVQSDSILTPVQVLPAQLQ
                     EKWRNQSSVSMNRAFSLPGGETISINSAHGLIMDDSGKKERFSVTERNGLCSNAVSGIA
                     ADGRGNLWGATDNGVFHVFIPSLFSRYTSGEGLKGEVISAVSYKGMIYTGTLQGLYVLK
                     QNTFVPVQGISQACWRLCLSPQGELYAASGDGVYVIRDYNHSEKLTDMAAYSLAFIGHT
                     NLLMGTMDGIYQYSADEERIKKISDVEKVVRLEVKKDRSVWAKTLYGEIYLREEGESSF
                     VLQDRESEEVMTEYTDNDGCHWQTNLKGKEVQVHHSQIDTEKFNQCLYAIRNYVVRVIY
                     IEEDRAAWFGGDFGLIRMDLEKARTFTPVAPRIYLREICLNRDSVYWGGDLPEESGGAD
                     WQINSTAPRLGNDVRSIRFSFATDAPCFTGSNEYRYRLVGYDPEWSSWDPGTVKEYANL
                     SSGTYTFCVRARDIYGTESEMKQFRFSLLPPFYLQWYCLILYAVAFGMLLFLLFKWRMR
                     SLLKEKERLEALVGQRTKQLVQQKNEIEEKSLKLEKALKELGQAQDELVRQEKMATVGK
                     LTQGLIDRILNPLNYINNFSHLTSGLLKDLYQNLESVKELLDEDTYLDSVDVINMMRDN
                     LEKIEEHGSNTTRVLKAMEEILRDRNRQLEKTELIGLCRKDMELLSSYYQKEITAMHIA
                     VRTSLPDNPLFIDGNAEQLGKTIMSLLNNGMYAIAKKYGKKAYPAEIGLALESKDGQAV
                     IRLYDNGVGIEQSILDKIFDPFFTTKTTGEAAGIGLYLSKEIILNHHGQIAVRSEKDEL
                     TEFTITLPLWEEKSV"
     CDS             complement(9341..10942)
                     /locus_tag="ctg238_6"
                     /transl_table=11
                     /translation="MIKLNENIIRWIIAVPCILLTVCLVLYRAYRHSASDRERLALSLE
                     EFRDKEKKSVLIQRVSQQMEEIAYQQKDISEKRRQEAVAQTQKANRMQQQAELARERAL
                     AAQLEAEKAYRMADEQKNLAMERQLQAEQSKRVADTLAFLALGRSLGTLSVTQYRSGNM
                     ELASLLAYTAWWFTKRYDGDVYHPAVFNALSLSCRQDQLWFGHKGAVTGIKLLSEGEEK
                     ARAGRNPLPGLVTVGKYGEMIRWKSENGQTYTSELLLNDPCYDFRDVLLRSDSQMYALS
                     YCGQLISTDSAGIVTRFLPKGEYRQLISIASNLVLAVSTTGIYSFDCVNHEIQPYFQPE
                     HSITCVGQMEGYLYVFFKNGTVALLSSDGTFLRFIDSLPENSVVTAFCPLTNERYAIGC
                     REGVILICDKNGNIRQKLIGHQAAVTAISRKGNKLFSSSYDCTLRLWDLRKGKTESAVI
                     VTSPGWIHTFCFHPDGTSVFIGDEQGRLYRVPVSPDHMATVVRQGLQRDFTREEWEYYI
                     GKQIPFESYYLKTYQP"
     CDS             complement(10939..11367)
                     /locus_tag="ctg238_7"
                     /transl_table=11
                     /translation="MTLLQFRPVDGRLDEILSMLMHSREVASHPSLSYAIRLVSEEIIV
                     NILNYAYPQQAEGYLTLCLWDEDGEITLEFIDGGIPFNPLDKADPDISLPLEQREIGGL
                     GIFLVREMMDDVAYTYVNKENRLTIKKKYLQPTDEPVS"
     CDS             complement(11382..11687)
                     /locus_tag="ctg238_8"
                     /transl_table=11
                     /translation="MEKYEIHFVGSVLDSNTSGDEQAKIVALIEQGHSVALDLSGCSYV
                     SSAGLRVMLYAFKLAKAKSRDVCLVGVSQEVKDVMHMTGFDKFFRFYQTLDELSQP"
     CDS             complement(11706..12875)
                     /gene_functions="other (smcogs) SMCOG1054:hypothetical
                     protein (Score: 219.1; E-value: 2.2e-66)"
                     /gene_kind="other"
                     /locus_tag="ctg238_9"
                     /transl_table=11
                     /translation="MAVKILSVDDELDLEVLLTQYFRRQIRKGEYEFAFAHNGLEALQK
                     LLETPDFDIILSDINMPEMDGLTLLAKVNELKNPAMKCIMVSAYGDMDNIRSAMNKGAF
                     DFATKPIDLDDLSRTIEKAIEQVRYIRESQQEHNQLESIKNDLAIAGEIQQTILPRSFP
                     PFPELTEVVDIYASMTPAKDVGGDFYDFFQIDDERIGLVIADVSGKGVPASLFMAVSRT
                     LLRATALRGVSSAECLTYANKLLCKESLDSMFVTVFYGIYHYKTGMMDYTNAGHNPPYL
                     LRGGRTVECLPVASNFVVGVFDDIEFESNTLTFGIGDTLLLYTDGVTEAFNDKREQFSE
                     SNLQDILASMHESSSAKEVVTSVLQSVKTFSGDYPQSDDITLLSLQRIK"
     CDS             13223..13777
                     /locus_tag="ctg238_10"
                     /transl_table=11
                     /translation="MLIILKQDDSCQVAQTTCTTNSLEIRYKDYSVLKKTLDLNTKSIN
                     SNSCIELIIYGTHGNEKEICKLTKPDIKDLSYFFKGKVCRLVLDACHSACHIPHFKEML
                     TDDGIILCHVGICQVNSIETKTGKDTYERWINGNKEGLKVWSDGIVPAIYTRKNNTLTY
                     YECSKFEVDINHPFTGTEFKTY"
ORIGIN
        1 aaataattaa ttgatgcgta gcctctgcaa gatctgactt caggtgatac aaataggtac
       61 gaccggttaa tctttcttcc attatccgtt ctagttcttt ccgtatatca tcagatggat
      121 cgatttccat aacacgcggt atgatggctc ccgaagctgt agactcccct tcctgacctt
      181 gcaaataatc atattgggac aaagtatagt ccatcagctg atcatagttt agttttttcc
      241 tggaagatat cgtttctgcc aaaggaatat agtaaagaat atccttgata aaagagctat
      301 attcagtctg tacgcggcgt accagattca tatacttttt ttcttcggat gataaatgcg
      361 tagaagtgaa agaaaaggat gcggcaacca tctgatattc aagcccttta ttgatttctg
      421 tcaacacctc tttggcatat gcatagtttt tcatggatat agacgaaaca accatattca
      481 acacatacaa atcaatagat ttgagattct ctgccagttc ttgtttgaaa ccggtaaacc
      541 aatcttgttg ctgagtataa attatggtat ctaactgcag gagtttcaaa tcgtgatgaa
      601 gtacacctgt ctgctgaagt gtcttgttca gaatcataat cgagatgacc cctccgatga
      661 ttcctccaat ataactgccg ccgaaaccta tccaggtggg cacatcgtct gcacccgcca
      721 tcagagtcaa cggattcagt tcgattaatg cccaattgat tggaaaaggc agtacaagag
      781 tcaagccaag taaaataaga agctctttct tacctaaagt gaagttttca gtctgcataa
      841 atctacttca aaaacacagt tattaattgt tccaatgatt ccccttctaa aaagtgccaa
      901 tgatctgccg gcaatcgcaa aacaggagcg ttcggataat atttattcca taatctttcg
      961 caattgtcat attctgtccg gaatatacga tagttttcct ccgtccacga ctcttcagga
     1021 gacaatcccg cctgttgatg gaacaatccg gacagcaaaa caataacctc tccctgataa
     1081 atcagattag gagtggttcg aaaataaata tttatgattt cgttccgttc acgtaccatt
     1141 tcatctgtat ctccgggaaa taccaacaaa ggataatttt gacagagagc cggattttgc
     1201 caagcctgtc catccagagc aaaaactttt ggcattatcc ccatggagcg atgtaacatt
     1261 tcggccaggc cgacagccag ttcagctccc atacagaagc cggtaagcgc atagacggta
     1321 cgctcccgga tcatcggctg aaccgtccgg acataatatt ccaacagttc cggaatatcc
     1381 gtagcaactt tattaaaatg atcgtagata gcatctacaa ctagaaagtc atatttggga
     1441 taaaggcggt cggccaaatt aaagtacaaa tgattaaaat aggcagatcc acaaaccaga
     1501 atgattacgg gtttcttcag gttttgctgc ctgtaccaat agataggttc ttgccgcgga
     1561 acgagcaata atcggcgcag attacgggca gtataaactg cagatacgtt gatgggacat
     1621 ccttttttat tggcctcggt aacaagcctc aacatatcca gcgaagttaa tcccagatca
     1681 tcaatcaaat cggcctcaac actgacttga ggcaaaccta acatttcctt caaaattcca
     1741 cataagataa cctcgcccgg atgaacagga ggaacatact tcaactccaa tgaagtaaaa
     1801 gccgggagcg cccggacatc aatcttatca tttatagtac gctgaaaatg atctaccacc
     1861 tgccataaat cgggtatcat gtagtaagga agttctgcac gcaaacgttc tttgacctct
     1921 tccggatgaa agttaccgga gactgagggt tgcaaataag ctcccaataa ttgacgccca
     1981 ttccgctcaa caactactac gtgggctctc tccacgtccg gatctctatt caatcgttct
     2041 gctatttcag tcaattcgat acgaaagcca cgtattttga cctgagtatc ttttcgcccg
     2101 ataaaccgta ttgaaccgtc cggttgctgc tgtaccaagt cacctgtcct gtacaaccgt
     2161 tctccatcgt acgagatgaa tgatttttca ttcagctgaa cactcccaat atatcccagc
     2221 gaaacctgag gtcctcccaa gcaaagttct cctgtagccc caagagttgt ctgttggagg
     2281 ttttcagaca aaacataaca gacagttccc ttgagcggat agccaatatc gtcatacgac
     2341 gtatctttgc ctacaatccg tatggtactg agtacggtat tctctgtcgg tccatataca
     2401 ttcatcaacc ggtaaggctg ctgtttcagc ctgttaaata acttttcacc aatagcctcc
     2461 gcaccaaaga gcagagtctt aaaggatgga aagtcaaggt cggcaaacat gcccagcaac
     2521 gaaggaggaa aaaaagcaat attcaccttc tcgcgcctga tcagttcgtc tagtaaagaa
     2581 atatctctgc gttcgtcctc accggccagg atcaatgttc ctccgaccgg aatacacatc
     2641 atcagttcta atatggaagc atcaaaactg atactcgcaa acgccagata cctgtttgcc
     2701 ggatcagaca aatgatacaa tttcttatct atcagattcc tcgtaaatgt atccagattc
     2761 cgataactaa tacgtacacc tttaggattg cctgttgttc cggaagtata tataatatag
     2821 gcgcaatcat cgggaagaac ttcagtatag tcaccaacaa ccggttcgga tagttgctcc
     2881 ccattcaggt aaagttggcg gacggacgga attccaccta cttcattcga tgaatcggtc
     2941 aacaacaaaa ccatatccgc attttcagcc atataccgtt tacgattatc cggcagcgag
     3001 ggatctatcg gtaaataagt tgcccctaac cggaaaatag ccagaatggc aggtactaaa
     3061 gttttgtttc gttccataca aactccgata cagatattcc gaagtccgga cggatcagtt
     3121 accgataaac gttgacggat agattgtgct atattggcag agtaacgttc cagcatttga
     3181 taagagacgg taccgtcttt tgcaacgacc gccggtttgt caccccaggt agagagtgat
     3241 cgagaaagat tttcttgaat gtttgttttc attattagtt tgatttagaa attatacaat
     3301 atactggcgg aaatccacct tcctttctgg cggataggaa cagtcgctcc tccgcattca
     3361 tatcggttat tgaaaagatt ctcaatgccc agactgcctt ctatcctttt atacttatat
     3421 ctggtagtga aagaaaagac agcataaccg ggcaaacgga ctgtgtaatt cgtcgcatct
     3481 ccattgagtc catcttccaa tacacttacc tgagtgtagc agtggctact gcaattcaat
     3541 tttaaatggg cagaccagct ctgtactttc tttttaagta aaaagtagtt tgctacaaga
     3601 ttcatagaaa agccgggtac gttattcaca gatccatcgg taacaaaaaa attggtataa
     3661 ttcaatactt tctgaaaaca caggtttcca tccaggctca gtcggtctgc cttataacgg
     3721 gcaacgacct cgacacctcc catatccaga gaaccggcat tttcataaac acgtgtttcc
     3781 ggctgtgtga acaggaaatg ggacgcccga ttataaaata aattacactc tacatctata
     3841 tgtgaaggtg aatgatgata agcacaagtc acctgatatg aacttagata ttcagcttgc
     3901 agattttcgc cacccgaata ggtatccatt tcattgtttc tgtaataata gggcgcatcg
     3961 acaaatgctc tggaataact ggctttgata tttaatccgt tcctgagata aattagtgac
     4021 agacggggag aaaaagcctg taatgtccgc ttattacttc gccgtttata gtcatacctg
     4081 atgccggcat tgacaatcca atttttatgc aggttgtgtt taatctggag aaaggcatcc
     4141 gtgttcatct cgtgtcccgt gtaaagtcgt ttttcgatcc acgtcctgac gatctcttta
     4201 aaattcatac cttccaaata ctcggaatca taaagcgtat accgattcca ttccacaccg
     4261 ccaagcatat tgcctttccc cagcttcccc caatcatagg catagtttac acgcccatta
     4321 aagcctacgt taaaatccat ccagcggatg tattgaaatg ctccgcgagt cggataaata
     4381 ataggttgat aatcatagtt aggaaaaata ggatagtctt gtaaagtatc tcccgaggtt
     4441 tcataatgta cgtttttatt ccaatcggta taaaatgcgg tactgaaagt gatccgctgc
     4501 cacgtgcggc tataaacagc ctgttctctt gccgaccacc tggaatatcc cgggccggaa
     4561 ccgtcaaaag tacgaaaccg ctcataagaa tatggagaag aaaagagcca catgctataa
     4621 ggttgccttt tcttcgcgta attcatactg aaactaaaaa gcaaatttcc acgttgcaat
     4681 ttaattcctc catccatggc aggaaatccc gaataattgt ccagacggat gaatccgtcc
     4741 ctggggtaaa gagcatattg tttttcggcc gggacaaaaa ccgattctcc cgttgcacgg
     4801 tacaaggaga accatgccat aaagtccatg ttcatgtcgt gctttcccaa tagcaggtca
     4861 gcagccaact ggccccgatt accggcactg acagatatgg aaccattacg aacatccacc
     4921 ccgtctttag taactatatt aatcacggct gtcaaagcca cactgccata aagcgaagaa
     4981 gccggtccgc gcagcacctc tatttgtttg acttttgcca gactaatacc ataatccggc
     5041 gaaacagcat tagtaatata actgttcaga cgttgtccat cctgcataat caatatgttc
     5101 tcctgttcgg gagaatatac cccgcgcata gccagattca tctcttcatt ggaagacaaa
     5161 ccggatatac cgggcacata agctatcagt acatcccgca ggcaccgggc atggatagcc
     5221 cgtatcatct cctccgtaat taaagtaaca ggcaccggag cttcttccgg ggtctctacc
     5281 tgttgtgagg ctgtgaccag agttacttta gtctccctgt gtttccttac catatccgca
     5341 aagcgttccg gatcttgaag cgagatataa taataaggtt cgtctttcaa taacagcgaa
     5401 acatactttt ccgcttccgg gaagcggtct aaagctaaac agcataatgc agccaaacgg
     5461 cacgcctcgg tatgcatcgt accttgaaaa gacgacagat tctcctccaa gatacgacaa
     5521 gcttcatcga tatctccgct cttataaaat gtttccgcct ttacaaacga attacggatg
     5581 ttatccgccg gctgagctga cagttgcaca accccaaagc agcaaaggat atatagcaga
     5641 cagcgtttca tgcgatagga atgataaacc ggaaacaagt atattcatgc aggaccgaat
     5701 caaacaatac ttttccatgg tgtttgtttt ctataatatc acgaacgatt gccataccaa
     5761 ggcctgtccc ctgccccacc ggttttgttg tgaaaaaaga gtcaaatagt tttcgtttga
     5821 cctccggact catgccctct ccgttatcac gaatagaaag tacaactctt ttatccaact
     5881 tttctaaagt caccattatc tcgggggaat atccttcggg agcattctgc cattttttcc
     5941 atactgcata gcaggcatta ttcatcacat tcaagactgc ccgactgaaa tcctgcggga
     6001 tcagccggat cgaggggata tctttagcat aatcttcacg gatagcaata ttgaaattct
     6061 tataattggc ccgcatggca tgataagcca gccacacata ttctttagtc aatttttgta
     6121 tttgtgtagg catgaattcg tcttctttcc ccctggagta aagcaaaata ccacgaataa
     6181 tgctgatagc ccgatcacca tgctctttga ttttgtccac attctctctc agcccggaaa
     6241 gtatatcttt gatatcttcc agttccgctt ccggaatacg agcttttgct tcatccaccc
     6301 tatcggccag gtcggccaac aattgaccgg acagtttact gaaattgatg acaaaattca
     6361 aaggattctg tatctcgtgt gcaatgcctg cactcaacaa gcccaatgat cccagctttt
     6421 cctgctcttt gagccgtgct tccaactctt caattcgttt ctcttgtgaa atgttttttt
     6481 ccataatcaa tctgttctat gtttatttat actgactttt cctcccacaa tggcagagtg
     6541 atagtgaatt ctgtcaattc atctttttca gaacgtactg ctatctgccc atggtgattt
     6601 aatatgattt ccttactcag atacaaaccg atacctgctg cctctccggt tgttttggta
     6661 gtaaagaacg gatcgaagat tttatccaga atactctgct cgatccccac tccattgtca
     6721 tataggcgaa tgactgcctg tccgtcctta ctttccaatg ccaggccaat ctctgccgga
     6781 taggctttct taccgtattt tttggctatg gcatacatac cattgttaag aagactcata
     6841 atggtttttc ccagttgttc ggcattcccg tcaataaaca acggattatc gggcaaggaa
     6901 gtacgaaccg caatgtgcat agccgtaatc tccttctgat aataactgct caatagctcc
     6961 atgtctttcc ggcataaacc gattaattct gttttttcca gttgcctgtt acggtctctc
     7021 aggatttctt ccatggcctt cagtacacga gtggtgttac ttccatgttc ctcaatcttt
     7081 tccagattat ctctcatcat gttgatgaca tctaccgaat ccaagtaggt atcttcatcc
     7141 aaaagttctt ttacactctc cagattctga tataggtcct tcagtaatcc tgaggtcaag
     7201 tgggaaaaat tattaatgta attcaacgga ttcagaatac ggtcaatcaa cccttgagtc
     7261 agtttaccta cagtagccat tttttcttgt cgaaccaatt catcttgtgc ctggcccagc
     7321 tccttcaatg ctttttccaa ttttaaggac ttttcctcaa tttcattctt ttgttgtacc
     7381 aactgtttgg tacgttgacc gacaagggcc tctaacctct ccttctcttt cagcaaactg
     7441 cgcattctcc atttaaataa taagaacaac agcattccaa aagcaacggc atatagaatc
     7501 agacaatacc attgcaaata aaaaggaggc aataacgaaa agcggaattg tttcatttca
     7561 ctctctgtac cgtaaatatc acgggcccgg acacaaaacg tatacgtacc cgacgaaagg
     7621 ttggcatact ctttcacagt cccgggatcc cacgaactcc attccggatc ataaccgacc
     7681 aggcgatatc tatactcatt ggagccggtg aaacagggcg catcggtagc aaatgaaaaa
     7741 cgaatggaac gtacatcatt ccccaaacga ggtgctgtac tatttatctg ccagtccgct
     7801 cccccagact cttccggcaa atctcctccc caatagacag aatcacggtt cagacaaatt
     7861 tcacgaagat agatgcgggg agcaaccgga gtaaatgtcc gggccttttc aaggtccatc
     7921 cgaattaaac caaaatcacc gccgaaccat gccgccctgt cttcttcaat ataaatcacc
     7981 ctcacgacat aattccgaat ggcatacagg cattggttga atttctccgt atcaatttgc
     8041 gaatgatgta cctgtacctc ttttcctttc agatttgtct gccaatgaca gccatcgttg
     8101 tccgtatact cggtcattac ttcttcactc tctctgtctt gaagtacaaa agagctttcg
     8161 ccctcttccc gcaaatagat ttctccgtac aacgttttag cccatacaga acgatctttc
     8221 ttcacttcca gacgaacgac tttttcgaca tcggaaattt tctttatccg ttcctcatct
     8281 gccgaatatt gataaatccc atccatagtg cccatcagaa ggttcgtatg cccaatgaat
     8341 gccaatgaat aagctgccat atctgtgagt ttttccgaat gattataatc ccggatcaca
     8401 tacacaccat cgccggacgc tgcatataat tctccttgtg gagaaagaca cagtcgccaa
     8461 catgcttgcg aaattccctg aacaggaaca aaagtgtttt gcttcaatac gtataatccc
     8521 tgtaaggtcc cagtatatat cattcctttg taagagacag ccgatattac ctctcccttc
     8581 agaccttcac cagaggtata acggctgaac aaagagggaa taaaaacatg aaacacaccg
     8641 ttatccgtag ctccccagag attgccacgc ccatcggccg caatacccga aacagcgtta
     8701 ctgcataagc catttctctc agttacggaa aaccgttctt ttttcccact gtcatccatt
     8761 attaatccat gggcagagtt tatcgagatt gtttctcctc cgggtagaga aaacgcccga
     8821 ttcattgaga ctgaggattg atttctccac ttttcctgca attgggccgg aagtacctga
     8881 accggtgtca aaatggaatc tgactgaacc gtataatatc ttcctgatgt agctttcaga
     8941 taaatgcgtt tatctatttc tgccatatct tccaattcgc ccaaagagtc tgtgtccaga
     9001 tcggaaagaa gggttctcaa cgtaatacat ccgcgtccat cacgctctat ccgtccgaac
     9061 acgttatatc ctcccaccca tatcctacct tccgaatcac gaaacaaacg ggtgacacgg
     9121 gaaaaacccg gtgtataaat agtttcccaa cggttatagt cataatgaag gataccttcg
     9181 aaattagcaa aatagacatt tccacaactg tcgcaaacga catcgaaatt acgattgtgc
     9241 gcctgataaa ccgaagccgg atagtttaca aaaaacggga taccttcttg tgaatttgca
     9301 tataccgagc aaagacacat tatcaaaaag actatctttt tcatggctga tacgttttta
     9361 ggtaatagga ttcaaatgga atttgcttac cgatataata ctcccattct tctcgagtaa
     9421 aatcacgctg taacccctga cggacaacag tagccatgtg atcgggtgaa acaggcaccc
     9481 gatacaaccg cccctgttcg tctcctataa agacagatgt accgtccgga tgaaagcaaa
     9541 aagtatggat ccaaccgggg cttgtcacaa taacggccga ctcggtcttt cctttacgaa
     9601 gatcccacag acgcagcgta caatcgtaac tactcgaaaa cagtttgttc cctttccggg
     9661 aaatagcagt aaccgcagcc tgatgcccta tcaacttctg ccggatattt ccattcttat
     9721 cacaaatcag gatgactcct tcacgacagc caatggcata tctttcattg gtaagaggac
     9781 agaatgcagt aaccacacta ttctcgggca agctgtctat aaatctgaga aatgtaccat
     9841 ccgacgaaag taaagctact gtcccattct taaaaaaaac atagagatag ccttccattt
     9901 gaccgacaca agttatcgaa tgttccggct gaaaataagg ttgtatctca tggttgacac
     9961 agtcaaaaga ataaatacct gttgtggaaa ccgccaatac caagttagag gcaatcgaaa
    10021 tcaattgccg atattctcct ttaggcaaaa agcgggtaac gataccggcg gaatccgtgg
    10081 agataagctg cccgcagtat gacaaggcat acatctgtga atcggaccgc aacagcacat
    10141 cccgaaaatc ataacaggga tcattcaaca gtaattcgga ggtataggtc tgcccatttt
    10201 ccgatttcca acgtatcatc tcaccgtact tgccgacagt gaccaatccc ggcagaggat
    10261 tccgaccggc tcttgctttt tcctcgcctt cggataacag tttgatcccg gtaacagctc
    10321 ctttatgccc gaaccaaagc tgatcttgcc tgcaagacaa agacaatgca ttgaaaacag
    10381 ccggatgata tacatcgcca tcatatcgct tggtaaacca ccaggcggta tatgccaaca
    10441 gagaagctaa ttccatgttg cccgaccgat attgagtaac agagagtgtc cccaatgaac
    10501 gtcccaaagc caaaaaagcc aatgtatcgg caaccctctt cgactgttcg gcctgtagtt
    10561 gccgttccat cgccagattc ttttgttcat ctgccatccg atacgctttc tcagcctcca
    10621 attgtgcagc aagcgctctt tcccgtgcca actctgcctg ctgttgcatt cggttggcct
    10681 tttgagtttg cgcaacggct tcctgtcttc tcttttcgga aatatccttt tgttgataag
    10741 caatctcctc catttgttga ctgacccgtt gtataagaac cgatttcttt tctttatccc
    10801 ggaattcctc cagagacaga gcaagacgct ccctgtccga tgccgaatga cgatatgccc
    10861 ggtataggac cagacatact gtcaaaagta tacaaggaac ggcaatgatc caacggatga
    10921 tattttcgtt taacttgatc atgatacagg ttcatcagtg ggttgcagat atttcttttt
    10981 aatggtcaac cgattctcct tattcacgta cgtatacgct acgtcatcca tcatttcacg
    11041 taccaggaaa atgcccaatc ctcctatttc acgttgttct aacggtaatg aaatatcagg
    11101 atcggcttta tccaaaggat tgaatggaat accaccatct ataaactcca aagtaatctc
    11161 tccgtcttca tcccataagc acagagtcag ataaccttct gcctgctgcg gataagcgta
    11221 attgagaata ttgacaatga tctcctcact gaccaaacgg atggcataag acagggaagg
    11281 atgtgaagca acttcacgac tatgcatcag catactaaga atttcatcta acctcccatc
    11341 gacagggcga aactgaagta acgtcattgc tcaggtaatt tttagggttg tgataattca
    11401 tcgagagtct gataaaaacg aaagaattta tcgaatccgg tcatgtgcat cacgtcttta
    11461 acctcttgtg acacaccgac aaggcaaaca tctctacttt tagctttcgc cagcttaaag
    11521 gcataaagca tgactctcaa tccggcactg gatacataag aacagccgct gagatctaat
    11581 gcaacagaat gtccttgctc gataagagct acaatttttg cttgttcgtc accgcttgta
    11641 tttgaatcca agacggaacc tacaaaatga atttcatact tttccatcgt tcttttattt
    11701 taatattatt tgattcgttg aagagaaagc agggttatgt catcggactg aggatagtct
    11761 ccggagaaag tcttaacaga ctgcaataca ctcgtaacaa cctcttttgc ggaactactt
    11821 tcgtgcatag acgccaatat atcctgtaag ttactttccg agaattgttc ccgcttgtcg
    11881 ttaaaagcct ctgtgacacc atccgtatac agaagtaaag tgtcaccgat gccgaacgtc
    11941 aatgtattac tctcaaattc aatatcatcg aacacgccta ccacaaaatt agaagcgaca
    12001 ggcaagcatt caacagtccg tccgccgcga aggagataag ggggattatg cccggcattg
    12061 gtatagtcca tcatgccggt tttataatga taaatcccat aaaagaccgt aacaaacata
    12121 gagtccaggc tctctttaca cagtaactta ttggcataag taaggcattc tgccgacgaa
    12181 acaccccgaa gagcagttgc acggagcagg gtccgactaa ccgccatgaa caaggatgcc
    12241 ggcacccctt tcccagatac gtcagcaatc accagcccga tacgttcatc gtcaatctgg
    12301 aagaaatcat aaaaatcgcc acctacatct tttgccggag tcatggaagc ataaatatca
    12361 accacttccg tcagttccgg aaaaggagga aaggaacggg gaagaatcgt ttgctggatt
    12421 tctcccgcaa tggccaggtc atttttgata gattccagtt ggttgtgctc ctgctgtgac
    12481 tcacggatat agcgaacctg ttcgatcgcc ttttcaatag tccgcgacag atcatccaaa
    12541 tcgatcggtt tggttgcaaa atcaaacgct cccttgttca tagcagaacg tatgttatcc
    12601 atgtctccat aagcagagac cattatacac ttcattgccg gatttttcag ttcattgacc
    12661 ttagccaata gggtcaaccc atccatctcc ggcatattaa tatcactcag gatgatatcg
    12721 aaatcgggag tttccagaag tttctgtaaa gcttccaacc cgttatgggc aaaagcgaac
    12781 tcgtattcac cttttcgtat ttgtcgcctg aagtactggg taagtaatac ttctaaatcg
    12841 agttcatcat ctacactcaa tatttttact gccatatcta ttgttattta tgaatttcaa
    12901 ccgtttgttc tgacgtttat gatggcaaaa atagagcgtg accgccccgg ttacaatttt
    12961 atattttaaa caggaaaaat gtttttccga atggacgata ttgtcttata agcatacagg
    13021 tatattgctt tcgtgcctta gaagacagca cctgaaagat tgatttacac tcctgaaaga
    13081 aactattccg tattcagaaa ttatattttt aagatggaac ttttcttctc acttttgtca
    13141 ccgtaagctt acaaagaata aatagaaacg gcggattccg aaaagccgaa gaaagagtag
    13201 gaacttttta cgaattacta ttatgcttat tattttaaaa caagatgata gttgtcaagt
    13261 tgcacaaacg acatgtacaa caaactcttt agaaatccga tacaaagatt atagtgtact
    13321 gaaaaaaact ctggatttga acacaaaatc tattaatagc aatagctgta tagagttaat
    13381 tatttacgga acacacggaa atgaaaagga aatttgcaaa ctaaccaaac cagacataaa
    13441 agatctgagc tatttcttca aaggaaaagt ttgtagatta gttcttgatg cttgccatag
    13501 cgcctgccat attccacatt tcaaagagat gttaacagat gatggaatca tattatgtca
    13561 tgtaggtatc tgccaagtaa acagcatcga aactaaaaca ggtaaagaca cctatgaacg
    13621 gtggataaat ggcaataagg aaggattaaa agtatggtcg gatggaatcg ttccagctat
    13681 ctatactcga aagaataaca ctttaactta ctacgaatgt agcaaattcg aagtagatat
    13741 taatcaccct tttaccggaa ctgaatttaa gacttatt
//
