LOCUS       gnlProkkaJAOHLMFG_283  13633 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JAOHLMFG_283.
ACCESSION   gnlProkkaJAOHLMFG_283
VERSION     gnlProkkaJAOHLMFG_283
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 00:00:06
            Original ID  :: gnl|Prokka|JAOHLMFG_283
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13633
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13633
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[953:3383]"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      954..3383
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
     cand_cluster    1..13633
                     /SMILES="NC([*])C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /kind="single"
                     /product="NRPS-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13633
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS-like"
                     /region_number="1"
                     /rules="cds((PP-binding or NAD_binding_4) and (AMP-binding
                     or A-OX))"
                     /tool="antismash"
     CDS             complement(56..949)
                     /locus_tag="ctg201_1"
                     /transl_table=11
                     /translation="MQTENFTLGKKELLILLGLTLVLPFPINWALIELNPLTLMAGADD
                     VPTWIGFGGSYIGGIIGGVISIMILNKTLQQTGVLHHDLKLLQLDTIIYTQQQDWFTGF
                     KQELAENLKSIDLYVLNTVVSSISMKNYAYAKEVLTEINKGLEYQMVAASFSFTSTHLS
                     SEEKKYMNLVRRVQTEYSSFIKDILYYIPLAETISSRKKLNYDQLMDYTLSQYDYLQGQ
                     EGESTASGAIIPRVMEIDPSDDIRKELERIMEERLTGRTYLYHLKSDLAEATHQLIIYE
                     ENRINSILHKPEREMN"
     CDS             complement(954..3383)
                     /NRPS_PKS="Domain: AMP-binding (12-401). E-value: 1.8e-83.
                     Score: 272.2. Matches aSDomain:
                     nrpspksdomains_ctg201_2_AMP-binding.1"
                     /NRPS_PKS="Domain: PP-binding (509-568). E-value: 2.7e-10.
                     Score: 32.6. Matches aSDomain:
                     nrpspksdomains_ctg201_2_PP-binding.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: PP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     260.1; E-value: 5.3e-79)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg201_2"
                     /sec_met_domain="AMP-binding (E-value: 3.1e-88, bitscore:
                     285.4, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 4.8e-11, bitscore:
                     32.6, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTNIQENLSRSLSTWGDKPAVVAKDGTVSYQMLERYSANIAQSI
                     RQRLSVTDPSGLRNICIGVCMERNKTLVPAILAIFRLGATYLPIDPSLPDNRKRYMAEN
                     ADMVLLLTDSSNEVGGIPSVRQLYLNGEQLSEPVVGDYTEVLPDDCAYIIYTSGTTGNP
                     KGVRISYRNLDTFTRNLVDKKLYHLSDPANRYLAFASISFDASILELMMCIPVGGTLIL
                     AGEDERRDISLLDELIRREKVNIAFFPPSLLGMFADLDFPSFKTLLFGAEAIGEKLFNR
                     LKQQPYRLMNVYGPTENTVLSTIRIVGKDTSYDDIGYPLKGTVCYVLSENLQQTTLGAT
                     GELCLGGPQVSLGYIGSVQLNEKSFISYDGERLYRTGDLVQQQPDGSIRFIGRKDTQVK
                     IRGFRIELTEIAERLNRDPDVERAHVVVVERNGRQLLGAYLQPSVSGNFHPEEVKERLR
                     AELPYYMIPNLWQVVDHFQRTINDKIDVRALPAFTSLELKYVPPVHPGEVILCGILKEM
                     LGLPQVSVEADLIDDLGLTSLDMLRLVTEANKKGCPINVSAVYTARNLRRLLLVPRQEP
                     IYWYRQQNLKKPVIILVCGSAYFNHLYFNLADRLYPKYDFLVVDAIYDHFNKVATDIPE
                     LLEYYVRTVQPMIRERTVYALTGFCMGAELAVGLAEMLHRSMGIMPKVFALDGQAWQNP
                     ALCQNYPLLVFPGDTDEMVRERNEIINIYFRTTPNLIYQGEVIVLLSGLFHQQAGLSPE
                     ESWTEENYRIFRTEYDNCERLWNKYYPNAPVLRLPADHWHFLEGESLEQLITVFLK"
     aSDomain        complement(1680..1856)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg201_2_PP-binding.1"
                     /evalue="2.70E-10"
                     /label="ctg201_2_PP-binding.1"
                     /locus_tag="ctg201_2"
                     /protein_end="568"
                     /protein_start="509"
                     /score="32.6"
                     /tool="antismash"
                     /translation="LCGILKEMLGLPQVSVEADLIDDLGLTSLDMLRLVTEANKKGCPI
                     NVSAVYTARNLRRL"
     aSModule        complement(1680..3347)
                     /complete
                     /domains="nrpspksdomains_ctg201_2_AMP-binding.1"
                     /domains="nrpspksdomains_ctg201_2_PP-binding.1"
                     /locus_tags="ctg201_2"
                     /monomer_pairings="X -> X"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(2154..2216)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg201_2_0004"
                     /evalue="1.50E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg201_2"
                     /protein_end="410"
                     /protein_start="389"
                     /score="36.2"
                     /tool="antismash"
                     /translation="FIGRKDTQVKIRGFRIELTEI"
     aSDomain        complement(2181..3347)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg201_2_AMP-binding.1"
                     /evalue="1.80E-83"
                     /label="ctg201_2_AMP-binding.1"
                     /locus_tag="ctg201_2"
                     /protein_end="401"
                     /protein_start="12"
                     /score="272.2"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="LSTWGDKPAVVAKDGTVSYQMLERYSANIAQSIRQRLSVTDPSGL
                     RNICIGVCMERNKTLVPAILAIFRLGATYLPIDPSLPDNRKRYMAENADMVLLLTDSSN
                     EVGGIPSVRQLYLNGEQLSEPVVGDYTEVLPDDCAYIIYTSGTTGNPKGVRISYRNLDT
                     FTRNLVDKKLYHLSDPANRYLAFASISFDASILELMMCIPVGGTLILAGEDERRDISLL
                     DELIRREKVNIAFFPPSLLGMFADLDFPSFKTLLFGAEAIGEKLFNRLKQQPYRLMNVY
                     GPTENTVLSTIRIVGKDTSYDDIGYPLKGTVCYVLSENLQQTTLGATGELCLGGPQVSL
                     GYIGSVQLNEKSFISYDGERLYRTGDLVQQQPDGSIRFIGRKDTQVKIR"
     CDS_motif       complement(2289..2375)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg201_2_0003"
                     /evalue="1.20E-08"
                     /label="NRPS-A_a6"
                     /locus_tag="ctg201_2"
                     /protein_end="365"
                     /protein_start="336"
                     /score="27.3"
                     /tool="antismash"
                     /translation="LGATGELCLGGPQVSLGYIGSVQLNEKSF"
     CDS_motif       complement(2877..2933)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg201_2_0002"
                     /evalue="1.50E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg201_2"
                     /protein_end="169"
                     /protein_start="150"
                     /score="26.8"
                     /tool="antismash"
                     /translation="AYIIYTSGTTGNPKGVRIS"
     CDS_motif       complement(3114..3155)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg201_2_0001"
                     /evalue="3.50E-03"
                     /label="NRPS-A_a2"
                     /locus_tag="ctg201_2"
                     /protein_end="90"
                     /protein_start="76"
                     /score="11.0"
                     /tool="antismash"
                     /translation="LAIFRLGATYLPID"
     CDS             complement(3396..5762)
                     /gene_functions="transport (smcogs)
                     SMCOG1082:TonB-dependent siderophore receptor family
                     (Score: 166.1; E-value: 3e-50)"
                     /gene_kind="transport"
                     /locus_tag="ctg201_3"
                     /transl_table=11
                     /translation="MKPCLLYILCCFGVVQLSAQPADNIRNSFVKAETFYKSGDIDEAC
                     RILEENLSSFQGTMHTEACRLAALCCLALDRFPEAEKYVSLLLKDEPYYYISLQDPERF
                     ADMVRKHRETKVTLVTASQQVETPEEAPVPVTLITEEMIRAIHARCLRDVLIAYVPGIS
                     GLSSNEEMNLAMRGVYSPEQENILIMQDGQRLNSYITNAVSPDYGISLAKVKQIEVLRG
                     PASSLYGSVALTAVINIVTKDGVDVRNGSISVSVGNRGQLAADLLLGKHDMNMDFMAWF
                     SLYRATGESVFVPAEKQYALYPRDGFIRLDNYSGFPAMDGGIKLQRGNLLFSFSMNYAK
                     KRQPYSMWLFSSPYSYERFRTFDGSGPGYSRWSAREQAVYSRTWQRITFSTAFYTDWNK
                     NVHYETSGDTLQDYPIFPNYDYQPIIYPTRGAFQYIRWMDFNVGFNGRVNYAYDWGKLG
                     KGNMLGGVEWNRYTLYDSEYLEGMNFKEIVRTWIEKRLYTGHEMNTDAFLQIKHNLHKN
                     WIVNAGIRYDYKRRSNKRTLQAFSPRLSLIYLRNGLNIKASYSRAFVDAPYYYRNNEMD
                     TYSGGENLQAEYLSSYQVTCAYHHSPSHIDVECNLFYNRASHFLFTQPETRVYENAGSL
                     DMGGVEVVARYKADRLSLDGNLCFQKVLNYTNFFVTDGSVNNVPGFSMNLVANYFLLKK
                     KVQSWSAHLKLNCSSHCYTQVSVLEDGLNGDATNYTIRLPGYAVFSFTTRYKYKRIEGS
                     LGIENLFNNRYECGGATVPIRQKGRWISASILYNF"
     CDS             complement(5759..6595)
                     /gene_functions="regulatory (smcogs) SMCOG1003:sensor
                     histidine kinase (Score: 141; E-value: 1.1e-42)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg201_4"
                     /transl_table=11
                     /translation="MEKNISQEKRIEELEARLKEQEKLGSLGLLSAGIAHEIQNPLNFV
                     INFSKLSGQLLADLADRVDEAKARIPEAELEDIKDILSGLRENVDKIKEHGDRAISIIR
                     GILLYSRGKEDEFMPTQIQKLTKEYVWLAYHAMRANYKNFNIAIREDYAKDIPSIRLIP
                     QDFSRAVLNVMNNACYAVWKKWHNAPEGYSPEIMVTLEKLDKRIVLSIRDNGEGMSPEV
                     KRKLFDSFFTTKPVGQGTGLGMAIVRDIIENKHHGKVLFDSVLHEYTCFRFIIPIA"
     CDS             complement(6618..9455)
                     /locus_tag="ctg201_5"
                     /transl_table=11
                     /translation="MKKIVFLIMCLCSVYANSQEGIPFFVNYPASVYQAHNRNFDVVCD
                     SCGNVYFANFEGILHYDYNRWETIYTPGFSRVTRLFRDSEGRIWVGGYNVFGRIERDGR
                     GCITLRTLLSDLDTDSLGELEDMAEIDKRIYLKATSGRYYTVQSDSILTPVQVLPAQLQ
                     EKWRNQSSVSMNRAFSLPGGETISINSAHGLIMDDSGKKERFSVTERNGLCSNAVSGIA
                     ADGRGNLWGATDNGVFHVFIPSLFSRYTSGEGLKGEVISAVSYKGMIYTGTLQGLYVLK
                     QNTFVPVQGISQACWQLCLSPQGELYAASGDGVYVIRDYNHSEKLTDMAAYSLTFIGHT
                     NLLMGTMDGIYQYSADEERIKKISDVEKVVRLEVKKDRSVWAKTLYGEIYLREEGESSF
                     VLQDRESEEVMTEYTDNDGCHWQTNLKGKEVQVHHSQIDTEKFNQCLYAIRNYVVRVIY
                     IEEDRAAWFGGDFGLIRMDLEKARTFTPVAPRIYLREVCLNRDSVYWGGDLPEESEGAD
                     WQINSTVPRLGNDVRSIRFSFATDAPCFTGSNEYRYRLVGYDPEWSSWDSGTVKEYANL
                     SSGTYTFCVRARDIYGTESEMKQFRFSLLPPFYLQWYCLILYTVAFGMLLFLLFKWRMR
                     SLLKEKERLEALVGQRTKQLVQQKNEIEEKSLKLEKALKELGQAQDELVRQEKMATVGK
                     LTQGLIDRILNPLNYINNFSHLTSGLLKDLYQNLESVKELLDEDTYLDSVDVINMMRDN
                     LEKIEEHGSNTTRVLKAMEEILRDRNRQLEKTELIGLCRKDMELLSSYYQKEITAMHIA
                     VRTSLPDNPLFIDGNAEQLGKTIMSLLNNGMYAIAKKYGKKAYPAEIGLALESKDGQAV
                     IRLYDNGVGIEQSILDKIFDPFFTTKTTGEAAGIGLYLSKEIILNHHGQIAVRSEKDEL
                     TEFTITLPLWEEKSV"
     CDS             complement(9452..11053)
                     /locus_tag="ctg201_6"
                     /transl_table=11
                     /translation="MIKLNENIIRWIIAVPCILLTVCLVLYRAYRHSASDRERLALSLE
                     EFRDKEKKSVLIQRVSQQMEEIAYQQKDISEKRRQEAVAQTQKANRMQQQAELARERAL
                     AAQLEAEKAYRMADEQKNLAMERQLQAEQSKRVADTLAFLALGRSLGTLSVTQYRSGNM
                     ELASLLAYTAWWFTKRYDGDVYHPAVFNALSLSCRQDQLWFGHKGAVTGIKLLSGGEEK
                     ARAGRNPLPGLVTVGKYGEMIRWKSENGQTYTSELLLNDPCYDFRDVLLRSDSQMYALS
                     YCGQLISTDSAGIVTRFLPKGEYRQLISIASNLVLAVSTTGIYSFDCINHEIQPYFQPE
                     HSITCVGQMEGYLYVFFKNGTVALLSSDGTFLRFIDSLPENSVVTTFCPLTNERYAIGC
                     REGVILICDKNGNIRQKLIGHQAAVTAISRKGNKLFSSSYDCTLRLWDLRKGKTESAVI
                     VTSPGWIHTFCFHPDGTSVFIGDEQGRLYRVPVSPDHMATVVRRGLQRDFTREEWEYYI
                     GKQIPFESYYLKTYQP"
     CDS             complement(11050..11478)
                     /locus_tag="ctg201_7"
                     /transl_table=11
                     /translation="MTLLQFRPVDGRLDEILSMLMHSREVASHPSLSYAIRLVSEEIIV
                     NILNYAYPQQAEGYLTLCLWDEDGEITLEFIDGGIPFNPLDKADPDISLPLEQREIGGL
                     GIFLVREMMDDVAYTYVNKENRLTIKKKYLQPTDEPVS"
     CDS             complement(11493..11798)
                     /locus_tag="ctg201_8"
                     /transl_table=11
                     /translation="MEKYEIHFVGSVLDSNTSGDEQAKIVALIEQGHSVALNLSGCSYV
                     SSAGLRVMLYAFKLAKAKSRDVCLVGVSQEVKDVMHMTGFDKFFRFYQTLDELSQP"
     CDS             complement(11817..12986)
                     /gene_functions="other (smcogs) SMCOG1054:hypothetical
                     protein (Score: 219.1; E-value: 2.2e-66)"
                     /gene_kind="other"
                     /locus_tag="ctg201_9"
                     /transl_table=11
                     /translation="MAVKILSVDDELDLEVLLTQYFRRQIRKGEYEFAFAHNGLEALQK
                     LLETPDFDIILSDINMPEMDGLTLLAKVNELKNPAMKCIMVSAYGDMDNIRSAMNKGAF
                     DFATKPIDLDDLSRTIEKAIEQVRYIRESQQEHNQLESIKNDLAIAGEIQQTILPRSFP
                     PFPELTEVVDIYASMTPAKDVGGDFYDFFQIDDERIGLVIADVSGKGVPASLFMAVSRT
                     LLRATALRGVSSAECLTYANKLLCKESLDSMFVTVFYGIYHYKTGMMDYTNAGHNPPYL
                     LRGGRTVECLPVASNFVVGVFDDIEFESNTLTFGIGDTLLLYTDGVTEAFNDKREQFSE
                     SNLQDILASMHESSSAKEVVTSVLQSVKTFSGDYPQSDDITLLSLQRIK"
     CDS             13334..13633
                     /locus_tag="ctg201_10"
                     /transl_table=11
                     /translation="MLIILKQDDSCQVAQTTCTTNSLEIRYKDYSVLKKTLDLNTKSIN
                     SDSCIELIIYGTHGNEKEICKLTKPDIKDLSYFFKGKVCRLVLDACHSACHIPHF"
ORIGIN
        1 tataaattca tttttaatac tgaaataaaa aaataccata ttatattaat atatgtcaat
       61 tcatttctct ctcaggttta tgcagaatag agtttatacg gttctcttca taaataatta
      121 attgatgcgt agcctctgca agatctgact tcaggtgata caaataggta cgcccggtta
      181 atctttcttc cattatccgt tctagttctt tccgtatatc atcagatgga tcgatttcca
      241 taacacgcgg tatgatggct cccgaagctg tagactcccc ttcctgacct tgcaaataat
      301 catattggga caaagtatag tccatcagct gatcatagtt tagttttttc ctggaagata
      361 tcgtttctgc caaaggaata tagtaaagaa tatccttgat aaaagagcta tattcagtct
      421 gtacgcggcg taccagattc atatactttt tttcttcgga tgataaatgc gtagaagtga
      481 aagaaaagga tgcggcaacc atctgatatt cgagcccttt attgatttct gtcaacacct
      541 ctttggcata tgcatagttt ttcatggata tagacgaaac aaccgtattc aacacataca
      601 aatcaataga tttgagattc tctgccagtt cttgtttgaa accggtaaac caatcttgtt
      661 gctgagtata aattatggta tctaactgca ggagtttcaa atcgtgatga agtacacctg
      721 tctgctgaag tgtcttgttc agaatcataa tcgagatgac ccctccgatg attcctccaa
      781 tataactgcc gccgaaacca atccaggtgg gcacatcgtc tgcacccgcc atcagagtca
      841 acggattcag ttcgattaat gcccaattga ttggaaaagg cagtacaaga gtcaagccaa
      901 gcaaaataag aagctctttc ttacctaaag tgaagttttc agtctgcata aatctacttc
      961 aaaaacacag ttattaattg ttccaatgat tccccttcta aaaagtgcca atgatctgcc
     1021 ggcaatcgca aaacaggagc gttcggataa tatttattcc ataatctttc gcaattgtca
     1081 tattctgtcc ggaatatacg ataattttcc tccgtccacg actcttcagg agacaatccc
     1141 gcctgttgat ggaacaatcc ggacagcaaa acaataacct ctccctgata aatcagatta
     1201 ggagtggttc gaaaataaat atttatgatt tcgttccgtt cacgtaccat ttcatcggta
     1261 tctccgggaa ataccaacaa aggataattt tgacagagag ccggattttg ccaagcctgt
     1321 ccatccagag caaaaacttt tggcattatc cccatggagc gatgtaacat ttcggccagg
     1381 ccgacagcca gttcagctcc catacaaaag ccggtaagcg catagacggt acgctcccgg
     1441 atcattggct gaaccgtccg gacataatat tccaacagtt ccggaatatc cgtggccact
     1501 ttattaaaat gatcgtagat agcatctaca actagaaagt catatttggg ataaaggcgg
     1561 tcggccaaat taaagtacaa atgattaaaa taggcagatc cacaaaccag aatgattacg
     1621 ggtttcttca ggttttgctg cctgtaccaa tagataggtt cttgccgcgg aacgagcaat
     1681 aatcggcgca gattacgggc agtataaact gcagatacgt tgatgggaca tcctttttta
     1741 ttggcctcgg taacaagcct caacatatcc agcgaagtta atcccagatc atcaatcaaa
     1801 tcggcctcaa cactgacttg aggcaaacct aacatttcct tcaaaattcc acataagata
     1861 acctcccccg gatgaacagg aggaacatac ttcaactcca acgaagtaaa agccgggagc
     1921 gcccggacat caatcttatc atttatagta cgctgaaaat gatctaccac ctgccataaa
     1981 ttgggtatca tgtagtaagg aagttctgca cgcaaacgct ctttgacctc ttccggatga
     2041 aagttaccgg agactgaggg ttgcaaatag gctcccaata attgacgccc attccgctca
     2101 acaactacta cgtgggctct ctccacgtcc ggatctctat tcaatcgttc tgctatttca
     2161 gtcaattcga tacgaaagcc acgtattttg acctgagtat cttttcgccc gataaaccgt
     2221 attgaaccgt ccggttgctg ctgtaccaag tcacctgtcc tgtacaaccg ttctccatcg
     2281 tacgagatga atgatttttc attcagctga acactcccaa tatatcccag cgaaacctga
     2341 ggtcctccca agcaaagttc tcctgtagcc ccaagagttg tctgttggag gttttcagac
     2401 aaaacataac agacagttcc cttgagcgga tagccaatat cgtcatacga cgtatctttg
     2461 cctacaatcc gtatggtact gagtacggta ttctctgtcg gtccatatac attcatcaac
     2521 cggtaaggct gctgtttcag cctgttaaat aacttttcac caatagcctc cgcaccaaag
     2581 agcagagtct taaaggatgg aaagtcaagg tcggcaaaca tgcccagcaa cgaaggaggg
     2641 aaaaaagcaa tattcacctt ctcgcgcctg atcagttcgt ctagtaaaga aatatctctg
     2701 cgttcgtcct caccggccag gatcaatgtt cctccgaccg gaatacacat catcagttct
     2761 aatatggaag catcaaaact gatactcgca aacgccagat acctgtttgc cggatcagac
     2821 aaatgataca atttcttatc taccagattc ctcgtaaatg tatccagatt ccgataacta
     2881 atacgtacac ctttgggatt tcctgttgtt ccggaagtat atataatata ggcgcaatca
     2941 tcgggaagaa cttcagtata gtcaccaaca accggttcgg atagttgctc cccattcagg
     3001 taaagttggc ggacggacgg aattccacct acttcattcg atgaatcggt caacaacaaa
     3061 accatatccg cattttcagc catataccgt ttacgattat ccggcagcga gggatctatc
     3121 ggtaaataag ttgcccctaa ccggaaaata gccagaatgg caggtactaa agttttgttt
     3181 cgttccatac aaactccgat acagatattc cgaagtccgg acggatcagt taccgataaa
     3241 cgttgacgga tagattgtgc tatattggca gagtaacgtt ccagcatttg ataagagacg
     3301 gtaccgtctt ttgcaacgac cgccggtttg tcaccccagg tagagagtga tcgagaaaga
     3361 ttttcttgaa tgtttgtttt cattattagt ttgatttaga aattatacaa tatactggcg
     3421 gaaatccacc ttcctttctg gcggatagga acagtcgctc ctccgcattc atatcggtta
     3481 ttgaaaagat tctcaatgcc cagactgcct tctatccttt tatacttata tctggtagtg
     3541 aaagaaaaga cagcataacc gggcaaacgg attgtgtaat tcgtcgcatc tccattgagt
     3601 ccatcttcca atacacttac ctgagtgtag cagtggctac tgcaattcaa ttttaaatgg
     3661 gcagaccagc tctgtacttt ctttttaagt aaaaagtagt ttgctacaag attcatagaa
     3721 aagccgggta cgttattcac agatccatcg gtaacaaaaa aattggtata attcaatact
     3781 ttctgaaaac acaggtttcc atccaggctc agtcggtctg ccttataacg ggcaacgacc
     3841 tcgacacctc ccatatccag agaaccggca ttttcataaa cacgtgtttc cggctgtgtg
     3901 aacaggaaat gggacgcccg attataaaat aaattacact ctacatctat atgtgaaggt
     3961 gaatgatgat aagcacaagt cacctgatat gaacttagat attcagcttg cagattttcg
     4021 ccacccgaat aggtatccat ttcattgttt ctgtaataat agggcgcatc gacaaatgct
     4081 ctggaataac tggctttgat atttaatccg ttcctgagat aaattagtga cagacgggga
     4141 gaaaaagcct gtaatgtccg cttattactt cgccgtttat agtcatacct gatgccggca
     4201 ttgacaatcc aatttttatg caggttgtgt ttaatctgaa gaaaggcatc cgtgttcatc
     4261 tcgtgtcccg tgtaaagtcg tttttcgatc cacgtcctga cgatctcttt aaaattcata
     4321 ccttccaaat actcggaatc ataaagcgta taccgattcc attccacacc gccaagcata
     4381 ttgcctttcc ccagcttccc ccaatcatag gcatagttta cacgcccatt aaagcctacg
     4441 ttaaaatcca tccagcggat gtattgaaat gctccgcgag tcggataaat aataggttga
     4501 taatcatagt taggaaaaat aggatagtct tgtaaagtat ctcccgaggt ttcataatgt
     4561 acgtttttat tccaatcggt ataaaatgcg gtactgaaag tgatccgctg ccacgtgcgg
     4621 ctataaacag cctgttctct tgccgaccac ctggaatatc ccgggccgga accgtcaaaa
     4681 gtacgaaacc gctcataaga atatggagaa gaaaagagcc acatgctata aggttgcctt
     4741 ttcttcgcgt aattcatact gaaactaaaa agcaaatttc cacgttgcaa tttaattcct
     4801 ccatccatgg caggaaatcc cgaataattg tccagacgga tgaatccgtc cctggggtaa
     4861 agagcatatt gtttttcggc cgggacaaaa accgattctc ccgttgcacg gtacaaggag
     4921 aaccatgcca taaagtccat gttcatgtcg tgctttccca atagcaggtc agcagccaac
     4981 tggccccgat taccgacgct gacagatatg gaaccattac gaacatccac cccgtcttta
     5041 gtaactatat taatcacggc tgtcaaagcc acactgccat aaagcgaaga agccggtccg
     5101 cgcagcacct ctatttgttt gacttttgcc agactaatac cataatccgg cgaaacagca
     5161 ttagtaatat aactgttcag acgttgtcca tcctgcataa tcaatatgtt ctcctgttcg
     5221 ggagaatata ccccgcgcat agccagattc atctcttcat tggaagacaa accggatata
     5281 ccgggcacat aagctatcag tacatcccgc aggcaccggg catggatagc ccgtatcatc
     5341 tcctccgtaa ttaaagtaac aggcaccgga gcttcttccg gggtctctac ctgttgtgag
     5401 gctgtgacca gagttacttt agtctccctg tgtttcctta ccatatccgc aaagcgttcc
     5461 ggatcttgaa gcgagatata ataataaggt tcgtctttca ataacagcga aacatacttt
     5521 tccgcttccg ggaagcggtc taaagctaaa cagcataatg cagccaaacg gcacgcctcg
     5581 gtatgcatcg taccttgaaa agacgacaga ttctcctcca agatacgaca agcttcatcg
     5641 atatctccgc tcttataaaa tgtttccgcc tttacaaacg aattacggat gttatccgcc
     5701 ggctgagctg acagttgcac aaccccaaag cagcaaagga tatatagcag acaaggtttc
     5761 atgcgatagg aatgataaac cggaaacaag tatattcatg caggaccgaa tcaaacaata
     5821 cttttccatg gtgtttgttt tctataatat cacgaacgat tgccatacca aggcctgtcc
     5881 cctgccccac cggttttgtt gtgaaaaaag agtcaaatag ttttcgtttg acctccggac
     5941 tcatgccctc tccgttatca cgaatagaaa gtacaattct tttatccaac ttttctaagg
     6001 tcaccattat ctcgggggaa tatccttcgg gagcattatg ccattttttc catactgcat
     6061 agcaggcatt attcatcaca ttcaagactg cccgactgaa atcctgcggg atcagccgga
     6121 tcgaggggat atctttagca taatcttcac ggatagcaat attgaaattc ttataattgg
     6181 cccgcatggc atgataagcc agccacacat attctttagt caatttttgt atttgtgtag
     6241 gcatgaattc gtcttctttc cccctggagt aaagcaaaat accacggata atgctgatag
     6301 cccgatcacc atgctctttg attttgtcca cattctctct cagcccggaa agtatatctt
     6361 tgatatcttc cagttccgct tccggaatac gagcttttgc ttcatccacc ctatcggcca
     6421 ggtcggccaa caattgaccg gacagtttac tgaaattgat gacaaaattc aaaggattct
     6481 gtatctcgtg tgcaatgcct gcactcaaca aacccaatga tcccagcttt tcctgctctt
     6541 tgagccgtgc ttccaactct tcaattcgtt tctcttgtga aatgtttttt tccataatca
     6601 atctgttcta tgtttattta tactgacttt tcctcccaca atggcagagt gatagtgaat
     6661 tctgtcaatt catctttttc agaacgtact gctatctgcc catggtgatt taatatgatt
     6721 tccttactca gatataaacc gatacctgct gcctctccgg ttgttttggt agtaaagaac
     6781 ggatcgaaga ttttatccag aatactctgc tcgatcccca ctccattgtc atataggcga
     6841 atgactgcct gtccgtcctt actttccaat gccaggccaa tctctgccgg ataggctttc
     6901 ttaccgtatt ttttggctat ggcatacata ccattgttaa gaagactcat aatggttttt
     6961 cccagttgtt cggcattccc gtcaataaac aacggattat cgggcaagga agtacgaacc
     7021 gcaatgtgca tagccgtaat ctccttctga taataactgc tcaatagctc catgtctttc
     7081 cggcataaac cgattaattc tgttttttcc agttgcctgt tacggtctct caggatttct
     7141 tccatggcct tcagtacacg agtggtgtta cttccatgtt cctcaatctt ttccagatta
     7201 tctctcatca tgttgatgac atctaccgaa tccaagtagg tatcttcatc caaaagttct
     7261 tttacactct ccagattctg atataggtcc ttcagtaatc ctgaggtcag gtgggaaaaa
     7321 ttattaatgt aattcaacgg attcagaata cggtcaatca acccttgagt cagtttacct
     7381 acagtagcca ttttttcttg tcgaaccaat tcatcttgtg cctggcccag ctccttcaat
     7441 gctttttcca attttaagga cttttcctca atttcatttt tttgttgtac caactgtttg
     7501 gtacgttggc cgacaagggc ctctaacctc tccttctctt tcagcaaact gcgcattctc
     7561 catttaaaca ataagaacaa cagcattcca aaagcaacgg tatataggat cagacaatac
     7621 cattgcaaat aaaaaggagg caataacgaa aagcggaatt gtttcatttc actctctgtg
     7681 ccgtaaatat cacgggcccg gacacaaaac gtatacgtac ccgacgaaag gttggcatac
     7741 tctttcacag tcccggaatc ccacgaactc cattccggat cataaccgac caggcgatat
     7801 ctatactcat tggaaccggt gaaacagggc gcatcggtag caaatgaaaa acgaatggaa
     7861 cgtacatcat tccccaaacg aggtactgta ctatttatct gccagtccgc tccctcggac
     7921 tcttccggca gatctcctcc ccaatagaca gaatcacggt tcagacaaac ttcacgaaga
     7981 tagatgcggg gagcaaccgg agtaaatgtc cgggcctttt caaggtccat ccgaattaaa
     8041 ccaaaatcac cgccgaacca tgccgccctg tcttcttcaa tataaatcac cctcacgaca
     8101 taattccgaa tggcatacag gcattggttg aatttctccg tatcaatttg cgaatgatgt
     8161 acctgtacct cttttccttt cagatttgtc tgccaatgac agccatcgtt gtccgtatac
     8221 tcggtcatta cttcttcact ctctctgtct tgaagtacaa aagagctttc gccctcttcc
     8281 cgcaaataga tttctccgta caacgtttta gcccatacag aacgatcttt cttcacttcc
     8341 agacgaacga ctttttcgac atcggaaatt ttctttatcc gttcctcatc tgccgaatat
     8401 tgataaatcc catccatagt gcccatcaga aggttcgtat gcccaatgaa tgtcaatgaa
     8461 taagctgcca tatctgtgag tttttccgaa tgattataat cccggatcac atacacacca
     8521 tcgccggacg ctgcatataa ttctccttgt ggagaaagac acagttgcca acatgcttgc
     8581 gaaattccct gaacaggaac aaaagtgttt tgcttcaata cgtataatcc ctgtaaggtc
     8641 ccggtatata tcattccttt gtaagagaca gccgatatta cctctccctt cagaccttca
     8701 ccagaggtat aacggctgaa caaagaggga ataaaaacat gaaacacacc gttatccgta
     8761 gctccccaga gattgccacg cccatcggcc gcaatacccg aaacagcgtt actgcataag
     8821 ccatttctct cagttacgga aaaccgttct tttttcccac tgtcatccat tattaatcca
     8881 tgggcagagt ttatcgagat tgtttctcct ccgggtagag aaaacgcccg attcattgag
     8941 actgaggatt gatttctcca cttttcctgc aattgggccg gaagtacctg aaccggtgtc
     9001 aaaatggaat ctgactgaac cgtataatat cttcctgatg tagctttcag ataaatgcgt
     9061 ttatctattt ctgccatatc ttccaattcg cccaaagagt ctgtgtccag atcggaaaga
     9121 agggttctca acgtaataca tccgcgtcca tcacgctcta tccgtccgaa cacgttatat
     9181 cctcccaccc atatcctacc ttccgaatca cgaaacaaac gggtgacacg ggaaaaaccc
     9241 ggtgtataaa tagtttccca acggttatag tcataatgaa ggataccttc gaaattagca
     9301 aaatagacat ttccacaact gtcgcaaacg acatcgaaat tacgattgtg cgcctgataa
     9361 accgaagccg gatagtttac aaaaaacggg ataccttctt gtgaatttgc atataccgag
     9421 caaagacaca ttatcaaaaa gactatcttt ttcatggctg atacgttttt aggtaatagg
     9481 attcaaatgg aatttgctta ccgatataat actcccattc ttctcgagta aaatcacgct
     9541 gtaacccccg acggacaaca gtagccatgt gatcgggtga aacaggcacc cgatacaacc
     9601 gcccctgttc gtctcctata aagacagatg taccgtccgg atgaaagcaa aaagtatgga
     9661 tccaaccggg acttgtcaca ataacggccg actcggtctt tcctttacga agatcccaca
     9721 gacgcagcgt acaatcgtaa ctactcgaaa acagtttgtt ccctttccgg gaaatagcag
     9781 taaccgcagc ctgatgccct atcaacttct gccggatatt tccattctta tcacaaatca
     9841 ggatgactcc ttcacgacag ccaatggcat atctttcatt ggtaagagga cagaatgtag
     9901 taaccacact attctcgggc aagctgtcta taaatctgag aaatgtacca tccgacgaaa
     9961 gtaaagctac tgtcccattc ttaaaaaaaa catagagata gccttccatt tgaccgacac
    10021 aagttatcga atgttccggc tgaaaataag gttgtatctc atggttgata cagtcaaaag
    10081 aataaatacc ggttgtggaa actgccaata ccaagttaga ggcaatcgaa atcaattgcc
    10141 gatattctcc tttaggcaaa aagcgggtaa cgataccggc ggaatccgtg gagataagct
    10201 gcccgcagta tgacaaggca tacatctgtg aatcggaccg caacagcaca tcccgaaaat
    10261 cataacaggg atcattcaac agtaattcgg aggtataggt ctgcccattt tccgatttcc
    10321 aacgtatcat ctcaccgtac ttgccgacag tgaccaatcc cggcagagga ttccgaccgg
    10381 ctcttgcttt ttcctcgcct ccggataaca gtttgatccc ggtaacagct cctttatgcc
    10441 cgaaccaaag ctgatcttgc ctgcaagaca aagacaatgc attgaaaaca gccggatgat
    10501 atacatcgcc atcatatcgc ttggtaaacc accaggcggt atatgccaac agagaagcta
    10561 attccatgtt gcccgaccga tattgagtaa cagagagtgt ccccaatgaa cgtcccaaag
    10621 ccagaaaagc caatgtatcg gcaaccctct tcgactgttc ggcctgtagt tgccgttcca
    10681 tcgccagatt cttttgttca tctgccatcc gatacgcttt ctcagcctcc aattgtgcag
    10741 caagcgctct ttcccgtgcc aactctgcct gctgttgcat tcggttggcc ttttgagttt
    10801 gcgcaacggc ttcctgtctt ctcttttcgg aaatatcctt ttgttgataa gcaatctcct
    10861 ccatttgttg actgacccgt tgtataagaa ccgatttctt ttctttatcc cggaattcct
    10921 ccagagacag agcaagacgc tccctgtccg atgccgaatg acgatatgcc cggtatagaa
    10981 ccagacatac tgtcaaaagt atacaaggaa cggcaatgat ccaacggatt atattttcgt
    11041 ttaacttgat catgatacag gttcatcagt gggttgcaga tatttctttt taatggtcaa
    11101 ccgattctcc ttattcacgt acgtatacgc tacgtcatcc atcatttcac gtaccaggaa
    11161 aatgcccaat cctcctattt cacgttgttc taacggtaat gaaatatcag gatcggcttt
    11221 atccaaagga ttgaatggaa taccaccatc tataaactcc aaagtaatct ctccgtcttc
    11281 atcccataag cacagagtca gataaccttc tgcctgctgc ggataagcgt aattgagaat
    11341 attgacaatg atctcctcac tgaccaaacg gatggcataa gacagggaag gatgtgaagc
    11401 aacttcacga ctatgcatca gcatactaag aatttcatct aacctcccat cgacagggcg
    11461 aaactgaagt aacgtcattg ctcaggtaat ttttagggtt gtgataattc atcgagagtc
    11521 tgataaaaac gaaagaattt atcgaatccg gtcatgtgca tcacgtcttt aacctcttgt
    11581 gacacaccga caaggcaaac atctctactt ttagctttcg ccagcttaaa ggcataaagc
    11641 atgactctca atccggcact ggatacataa gaacagccgc tgagatttaa tgcaacagaa
    11701 tgtccttgct cgataagagc tacaattttt gcttgttcgt caccgcttgt atttgaatcc
    11761 aagacggaac ctacaaaatg aatttcatac ttttccatcg ttcttttatt ttaatattat
    11821 ttgattcgtt gaagagaaag cagggttatg tcatcggact gaggatagtc tccggagaaa
    11881 gtcttaacag actgcaatac actcgtaaca acctcttttg cggaactact ttcgtgcata
    11941 gacgccaata tatcctgtaa gttactttcc gagaattgtt cccgcttgtc gttaaaagcc
    12001 tctgtgacac catccgtata cagaagtaaa gtgtcaccga tgccgaacgt caatgtatta
    12061 ctctcaaatt caatatcatc gaatacgcct accacaaaat tagaagcgac aggcaagcat
    12121 tcaacagtcc gtccgccgcg aaggagataa gggggattat gcccggcatt ggtatagtcc
    12181 atcatgccgg ttttataatg ataaatccca taaaagaccg taacaaacat agagtccagg
    12241 ctctctttac acagtaactt attggcataa gtaaggcatt ctgccgacga aacaccccga
    12301 agagcagttg cacggagcag ggtccgacta accgccatga acaaggatgc cggcacacct
    12361 ttcccggata cgtcagcaat caccagcccg atacgttcat cgtcaatctg gaagaaatca
    12421 taaaaatcgc cacctacatc ttttgccgga gtcatggaag cataaatatc aaccacttcc
    12481 gtcagttccg gaaaaggagg aaaggaacgg ggaagaatcg tttgctggat ttctcccgca
    12541 atggccaggt catttttgat agattccagt tggttgtgct cctgctgtga ctcacggata
    12601 tagcgaacct gttcgatcgc cttttcaata gtccgcgaca gatcatccaa atcgatcggt
    12661 ttggttgcaa aatcaaacgc tcccttgttc atagcagaac gtatgttatc catgtctcca
    12721 taagcagaga ccattataca cttcattgcc ggatttttca gttcattgac cttagccaat
    12781 agggtcaacc catccatctc cggcatatta atatcactca ggatgatatc gaaatcggga
    12841 gtttccagaa gtttctgtaa agcttccaac ccgttatggg caaaagcgaa ctcgtattca
    12901 ccttttcgta tttgtcgcct gaagtactgg gtaagtaata cttctaaatc gagttcatca
    12961 tctacactca atatttttac tgccatatct attgttattt atgaatttca accgtttgtt
    13021 ctgacgttta tgatggcaaa aatagagagt gatcgacccg gttacaattt tatattttaa
    13081 acaggaagaa tgtttttccg aatggacgat attgtcttat aagcatacag gtatattgct
    13141 ttcgtggctt agaagacagc acttgaaaga ttgatttaca ctcctgaaag aaactattcc
    13201 gtattcagaa tttatatttt taagatggaa cttttcttct cacttttgtc accgtaagct
    13261 tacaaagaat aaatagaaac ggcggattcc gaaaagccga agaaagagta ggaacttttt
    13321 acaaatcact attatgctta ttattttaaa acaagatgat agttgtcaag ttgcacaaac
    13381 gacatgtaca acaaactctt tagaaatccg atacaaagat tatagtgtac tgaaaaaaac
    13441 tctggatttg aacacaaaat ctattaatag cgatagctgt atagagttaa ttatttacgg
    13501 aacacacgga aatgaaaagg aaatttgcaa actaaccaaa ccagacataa aagatctgag
    13561 ctatttcttc aaaggaaaag tttgtagatt agttcttgat gcttgccata gcgcctgcca
    13621 tattccacat ttc
//
