LOCUS       c00217_gnlPro..        14706 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JAOHLMFG_303.
ACCESSION   c00217_gnlPro..
VERSION     c00217_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-03 17:26:16
            Original ID  :: gnl|Prokka|JAOHLMFG_303
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14706
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14706
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[67:4706]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      68..4706
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..14706
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14706
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             68..472
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg217_1"
                     /sec_met_domain="Glyoxalase_4 (E-value: 1e-23, bitscore:
                     75.4, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKISHIEHLGIAVKSIEEALPYYENVLGLKCYNIETVEDQKVRTA
                     FLKVGDTKIELLEPTCPESTIAKFIENKGAGVHHVAFAIEDGVANALAEAESKEIRLID
                     KAPRKGAEGLNIAFLHPKSTLGVLTELCEH"
     CDS             598..2151
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg217_2"
                     /sec_met_domain="CT_Btheta (E-value: 9.7e-291, bitscore:
                     955.9, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKVKELIELRAQARLGGGEKAIEKQHAKGKYTARERIAQL
                     LDEGSFEELDMFVQHRCTNFGQEKKHFLGDGVVTGYGTIEGRLVYVFAQDFTVFGGSLS
                     ETMAQKICKVMDMAMKMGAPVIGINDSGGARIQEGINALSGYAEIFQRNIMASGVIPQI
                     SGIFGPCAGGAVYSPALTDFTLMTEGTSYMFLTGPAVVKTVTGEDVSQEDLGGASVHAS
                     KSGVTHFTAETGEEGLAIIRKLLSFIPQNNLEEAPLVNCTDPIDRMDDLLNEIIPDSPN
                     KPYDMYEVIGAIIDNGEFLEVQKDYAKNLIIGFARMNGQSVGVVANQPKYLAGVLDSNA
                     SRKGARFVRFCDAFNIPLVTLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTV
                     TLRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVAVLYAKEAKDQENPAQFLA
                     DKEAEYTKLFANPYNAAKYGYIDDVIEPRNTRFRVIRALQQLQTKKLTNPAKKHGNIPL
                     "
     CDS             2172..3086
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg217_3"
                     /sec_met_domain="OAD_gamma (E-value: 6e-16, bitscore: 50.6,
                     seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKKRIGIFIALLAMVCMGLRAQSATSLRINEVLVVNDQNYQDDY
                     GLHNAWIEIFNTSFASVNLEGCFLTNDKNNPTKYPIPKGDVLTLIKPRQHALFWADGMP
                     NRGTFHVNFTLDPNKENYIALYDSNGKTLIDEVTIPAGQLADRSYAREKDGSANWVVKG
                     EGEHSYVTPSTNNMTIDKNPKIENFKKHDSIGIGMAIIAMSVVFIGLVLLYLSFKAVGN
                     VAVRLGKKNAMKATGITDKTEAKEKNLGSHTGEETAAIAMALHEYLNDAHDVEDMILTI
                     NKVKRTYSPWSSKIYTLRQTPKR"
     CDS             3112..3543
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 69.7; E-value:
                     4.8e-22)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg217_4"
                     /sec_met_domain="Biotin_lipoyl (E-value: 3.8e-22, bitscore:
                     69.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQYKYKINGNLYNVTVNDVEDNIANVEVNGTSYKVELDKPVKAA
                     PKPVTRPAAAPKTETGAPVVTKQPTASKKDGVKSPLPGVILDIKVKEGDTVKRGQTIII
                     LEAMKMENNINANKDGKVAEIKVNKGDSVLEGTDLVIIE"
     CDS             3546..4706
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg217_5"
                     /sec_met_domain="OAD_beta (E-value: 1.9e-153, bitscore:
                     502.1, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGDFVSFLGNNLVDFWGYTGFANATPGHLFMLLIGLFFIYLAVAK
                     EFEPMLLIPIGFGILIGNIPFNMEAGLKVGIYEEGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLIGAAAQFGIFGAYIIALLIGFEPNQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPVIQPPIMRALTTKHERLIRMKPPRIVSHTEKVIFP
                     IVGLLLTCFLVPSGLPLLGMLFFGNLLKESGVTRRLANTASGPLIDVITILLGLTVGAS
                     TQASQFLTWDSILIFILGAFSFIIATASGVMFVKFFNLFLKKGNKINPLIGNAGVSAVP
                     DSARISQVIGLEYDPTNYLLMHAMGPNVAGVIGSAVAAGILLGFLM"
     CDS             4855..6186
                     /locus_tag="ctg217_6"
                     /transl_table=11
                     /translation="MRTRTMKPLFLIFCLCLSPLLMGQNQNKIQEAMANYDYETAVELI
                     NKEPPTIPLLMQKAKALKGIGSNAEALRSIRQVIAEDSTNQQAHIEAAECCKAMAKYND
                     ALDYYRKAISLNPKNKYARLQFINLLCNTKNYAEAFGESSMMSETDSSAVVLHLQAQSL
                     EGMQQILPAIGCYEVIQDKYPDDYLAAAKLGNLNIVAGYPEYAIQATERYRERDSTNLI
                     VNQQNALAYCHAEQYPTAIKRYEKLCQQGDSSTQTLYYLGVSYYADEYYYEAHACFSKL
                     QKEMEENPNLLYYLGRCCAKTSWKKEGIEHLEKAIELTIPKDSTMIRLYKGLVDCCKLA
                     QDTPKQIQALRELYKYDKTNHKLLYDIAWNYSYQLKDNKSAERYLQAFLKTRKANARKE
                     EPVSEKGELVLGLENYYNAAENWLKDLQKEKFFKEGIPLESQKQ"
     CDS             6200..7492
                     /locus_tag="ctg217_7"
                     /transl_table=11
                     /translation="MKHWILLLYLGFSVMLRAQNTASVQEAMANYDYKTVIRLIDEESA
                     SPQLLIQKAKALKGLGRTAEALSTLQHIIIELPENQQALVEAAECCRQLSKFNEALGYY
                     RKVMELNPEHIYAHLQYTRLLYNYQRYGDALRESIALARKDSSATVLRLMAESMEGAGM
                     PVESMFCYLSIIRKYPSDYLSVAKLGSIFNTMKDYEGAIALTEAYRRTDSTNVEVNRQN
                     ALAYCLRKEYPTAIKRYQDLTARGDSTLLTCYYLGVSYYATKEYYKARDWLLKAKSCQS
                     PGANLLYYLGRSCSKTLWKQEGIGYLNQAIALTIPADSIMERLYSGLADCYRQTKQTRD
                     QIKATKEQYKYAPDKHILLYNLAFLSDKIGDTKATEHYLQAFLRTKSKQNAVLQQPDDD
                     EEEPAPYIDYYKSATNKLESIRKEKFLKGEK"
     CDS             7996..9846
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Alpha-amylase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg217_8"
                     /sec_met_domain="Alpha-amylase (E-value: 2.6e-63, bitscore:
                     206.2, seeds: 19, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKLLLLLGSFLLSLTTYAAMNISKIDPPFWFTGMNNPELQLMVY
                     GEGIGQASVSVNYPGVSLSSIVKLESNNYLLVYLHLDKEVKPGKMPITFTVGKKKLVKE
                     YELKARSKAGVDHKGFDASDALYLLMPDRFANGNPDNDQIEGMAEYKVDRNDPNARHGG
                     DLAGIEQNLDYFTDLGVTALWFTPVLENNMKGGSYHGYATTDYYKVDPRFGTNEEYRSL
                     IAKAHNRGIKVVMDMIFNHCGVEHPWIKDMPSKDWFNHADFKNNFVQTSYKLTPHVDPY
                     ASEYDFDQMNNGWFVEAMPDLNQKNPHVYKYLLQNSLWWIEYADIDGIRMDTYPYADYD
                     AMSNWMKELNEEYPNYNTVGETWVTEPAYTAWWQKDSKLSAPRNSHLKTVMDFSFFDKV
                     NTAKNEQTDTWFKGLDRVYNNFVYDYLYPNPASVLAFIENHDTDRFLGEGENLDMLKQA
                     STLLLTTRRIPQLYYGTEVMMNGVKSKSDGYVRKDFPGGWADDKENALTPEGRTRLQNE
                     SYNFYRNLLNWRKGNDVIAKGSMKQFMVQHGVYAYARQYKGKTVFVLLNGTDKEVKLPL
                     KYYAEVLKDKTQGKDVISGKVTALNEELTMAPRQSMVIEL"
     CDS             10004..10444
                     /locus_tag="ctg217_9"
                     /transl_table=11
                     /translation="MTNNESERELVLQTLRTWMAFRQAVQRVLKRHNVDMTFEMLQVMN
                     CLWNKQGISQQSLAEKTAKDKACLTNLINNLEKKNWVIRKEGPSDRRNRLIFLTPQGEE
                     LALTVKPLINDIYAQTGTEMEASRITECIEDLKRLHEVLNEI"
     CDS             10457..11524
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Biotin_lipoyl_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg217_10"
                     /sec_met_domain="Biotin_lipoyl_2 (E-value: 1e-11, bitscore:
                     36.2, seeds: 52, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTHQIKLKQLRRLKFRNIFLNTVCILLALAGISWTVNYFWKYAR
                     YEITNDAVVDQYIAPLNIRIPGYIKEVRFTEHQYVHAGDTLLILDDREYRIRLKDAEAA
                     LMDALGSKEVLNSGIRTSGVNVAVQEANIAETLARLSQQEAELNRYTRLLKKQAVSQQD
                     YELAKANFEATRARYNALLRQKEAAQSQYSETSKRSTGAEANILRKEADLEMARLNLSY
                     TVVTAPYDGYTGRRTLEPGQFVQGGQTLSYLVRGNDKWVTANYKETQIAHIYIGQKVRI
                     KVDAFSGRTFHGTVTAISEATGSKYSLVPTDNSAGNFVKVQQRIPVRIDLNDASPEEME
                     CLRAGMMVETEAVRP"
     CDS             11529..13124
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg217_11"
                     /sec_met_domain="MFS_1 (E-value: 3.8e-14, bitscore: 43.9,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVKLNLPTRPWVPQWLGIVTMFIVIFPITLLNGAYTGSMVEVSNT
                     LGVLSEDITMAYYSASVGMAVAYPIVPKIRTIATPKTLLLTDLLLQIFFSLVCAKTGSM
                     DVIMVCSFCMGFLKAFVMLEFIILIRPLFSPKNVRSEFYAYFYPIVFSGGQLSMAITAQ
                     LAYHYQWQHMYYFVTILLLIAILFVICFFRYARRPMHIPFKEMDGRSMFIIATAFLLTL
                     YTFTYGKTLDWFASPKIRVYVFVIPLLIALFIHRQRTQGKPFVSLKPLFLHKSIIGYGF
                     MVLAMFLTATSSLVTNYMNSIIRVDSIHANSLSLWLLPGYVVGAVICFWWFRWQRWRFR
                     FLISGGMFCYVIYLAILYFGITPYGTYEMLYLPILFRGVGMMVIFIAFGVFVVEDLDPR
                     LTLSNAFFLISFRSVLAPVLSASFFNNMLYYLQAKGMNILSENMTLTNPLAEQKYNQAL
                     SNALTQGHEFGEAGQLAANSLYSTLQQQSLLLALKTLIGYVLILALVIAVFAAFIPFHK
                     TLKVAVVKTGDDMV"
     CDS             complement(13219..14223)
                     /locus_tag="ctg217_12"
                     /transl_table=11
                     /translation="MVNYKDLGLVNTRDMFAKAIKGGYAIPAFNFNNMEQMQAIIKAAV
                     ETKSPVILQVSKGARQYANATLLRYMAQGAVEYAKELGCKNPEIVLHLDHGDTFETCKS
                     CIDSGFSSVMIDGSHLPYDENVALTKKVVEYAHQFDVTVEGELGVLAGVEDEVSSDHHT
                     YTEPDEVVDFVTKTGCDSLAISIGTSHGAYKFTPEQCHIDPKTGRMVPPPLAFDVLDGV
                     MKELPGFPIVLHGSSSVPEEEVATINQFGGALKAAIGIPEEELRKAAKSAVCKINIDSD
                     SRLAMTAAIRKVFAEKPAEFDPRKYLGPARDNMEKLYKHKIINVLGSDNKLAE"
ORIGIN
        1 gattttcttt gtgctgtttt ataccattcc gaaaagacga ttaataccaa aatttaaaaa
       61 tatagttatg aagatttcac acattgaaca tttgggcatt gccgtaaaaa gtatcgaaga
      121 agcccttccg tattatgaaa acgttttagg tttgaaatgc tacaacatcg aaactgtaga
      181 agatcaaaaa gtaagaacag ccttcctgaa agtaggtgat accaaaatcg aattactgga
      241 acccacatgt ccggaaagta ccatcgcgaa attcatcgaa aacaaaggtg caggtgttca
      301 tcacgtggca ttcgccattg aagacggcgt agccaatgcc ctagccgaag ccgaaagcaa
      361 agagatccgc ctgatcgaca aagctccgcg caaaggtgcc gaaggcctga acatagcttt
      421 ccttcacccg aaatcaactc tgggcgtact gacagaactc tgcgaacact aaaaagatgt
      481 acgattcgga cgatccgcgc cacggacaaa cggaattttt ctttgcatta aattccccat
      541 ctgggttgtc aatcgtccgg ttgtaaatat tataaccctt taaattaaga aaaactcatg
      601 agtaaccagc ttgaaaaagt aaaagagctt attgaacttc gtgctcaggc tcgtttaggt
      661 ggtggcgaaa aggctattga aaaacaacac gccaaaggca aatatacagc ccgcgagcgt
      721 attgcacagt tgcttgacga aggtagtttc gaagaactgg atatgtttgt tcaacacaga
      781 tgtaccaatt tcggacaaga gaaaaaacat ttcctcggcg acggtgtggt aaccggttat
      841 ggaacgatag aaggtagatt agtatatgtt ttcgcacaag atttcacagt attcggtggt
      901 tcactgtcgg aaaccatggc acaaaagatc tgtaaagtaa tggatatggc catgaagatg
      961 ggtgcccctg ttatcggtat caacgactcg ggtggcgcac gtattcagga aggcatcaac
     1021 gccctgtccg gttatgctga aatcttccag cgcaacatca tggcttcggg tgtcatccca
     1081 cagatttcag gtattttcgg tccgtgtgcc ggcggtgcgg tttactctcc cgccctgaca
     1141 gacttcacgc tgatgacgga aggtacatct tacatgttcc tcaccggacc ggctgttgtg
     1201 aaaacagtaa cgggtgaaga cgtgtctcag gaagatctgg gtggtgcaag cgtacatgcc
     1261 agcaagtccg gtgtaactca cttcactgcc gaaaccggtg aagaaggtct ggcgattatt
     1321 cgcaagcttc tcagctttat tccgcaaaac aacctggaag aagctccatt ggtgaactgt
     1381 accgacccca tcgaccgtat ggacgacctg ctgaacgaga tcatccccga cagcccgaac
     1441 aaaccgtacg atatgtacga agtgatcggc gccatcatcg ataacggaga attcctggaa
     1501 gtacagaaag attatgcgaa aaatcttatt atcggttttg cccgtatgaa cggacaatcg
     1561 gtaggtgtgg ttgccaatca gcctaaatac ctcgccggag tactcgacag caatgcttca
     1621 cgcaaaggtg cacgcttcgt tcgcttctgc gacgcattca acattccgct ggtgacattg
     1681 gtagacgttc cgggattcct tccaggtacg ggtcaggaat ataatggtgt aatcctgcac
     1741 ggagccaagt tgctgtacgc ttatggtgaa gccactgtgc ccaaggtaac tgttaccctg
     1801 cgtaaatctt acggtggttc gcacatcgta atgagttgca agcaactccg cggcgacatg
     1861 aactatgcat ggccgacagc cgaaatcgcc gtaatgggcg gtgccggtgc agtagcggta
     1921 ttgtatgcca aagaagccaa agatcaggaa aaccctgctc aattcctggc agacaaggaa
     1981 gccgagtaca ctaaactgtt cgccaacccg tacaatgcag ccaaatacgg ttacattgac
     2041 gacgttatcg aaccgagaaa cactcgtttc cgcgtgatcc gcgccctgca acagctgcag
     2101 accaaaaaat taaccaaccc tgctaaaaag cacggtaata ttccattgta acaaattaaa
     2161 catcgattgt tatgaataag aaaagaatcg ggatatttat cgctctgctg gcaatggttt
     2221 gcatggggct cagggcgcaa agtgccacca gtctgagaat caatgaggtt ttggtcgtca
     2281 acgaccagaa ctatcaggat gactacggac tgcacaatgc gtggatagag atattcaaca
     2341 cctctttcgc ttctgtaaat ctggaaggtt gctttctgac gaacgataaa aacaatccga
     2401 ccaaatatcc tattcccaaa ggcgacgtgc tgactctgat caagccgcgc caacatgctt
     2461 tgttctgggc agacggaatg cctaaccggg gtacgttcca cgtgaacttt acgctcgacc
     2521 cgaacaaaga gaattacatt gctttgtatg actctaacgg taaaactctg attgacgaag
     2581 taaccatacc cgccggtcag cttgccgacc gttcatacgc tcgcgaaaaa gacggaagtg
     2641 ccaactgggt agtaaaaggt gaaggagaac acagctatgt cactccgagc accaacaata
     2701 tgactatcga caaaaacccg aagatcgaga acttcaagaa acacgactct atcggtatcg
     2761 gtatggccat catcgccatg tcggtcgtat tcataggttt ggtactcttg tatctttcat
     2821 tcaaggcggt aggtaacgta gcggtcagac tgggtaagaa aaacgcgatg aaagccaccg
     2881 gtatcaccga caagacggaa gcgaaggaaa agaacctggg tagccacaca ggtgaagaaa
     2941 ccgccgcaat cgccatggct ttgcatgaat acctgaatga cgctcacgac gttgaagaca
     3001 tgattttgac tatcaacaaa gtgaaacgca cctactcacc ctggagttcg aagatctaca
     3061 cactgcgtca gactccgaaa agataattac taaccctaat aaaatgaagc aatgaaacaa
     3121 tataaatata aaatcaacgg caacctttac aacgttacag tgaacgatgt agaagataac
     3181 atagccaacg ttgaagtgaa cggaacctct tataaagtag agttggacaa gcccgtcaaa
     3241 gccgctccga aaccggtgac ccgtccggca gccgctccga aaacggaaac aggtgctccg
     3301 gtagtaacca aacaaccgac agcttccaaa aaagacggtg tgaaatctcc gcttccaggc
     3361 gttatcctcg acataaaagt gaaagaaggg gataccgtga agagaggcca gacgatcatc
     3421 atccttgagg ctatgaagat ggaaaacaac atcaatgcca ataaagacgg aaaagtagca
     3481 gaaattaaag ttaataaagg agattctgta cttgaaggta cagacctcgt aatcattgaa
     3541 taattatggg agatttcgta tcattcttag ggaataacct tgttgacttc tggggataca
     3601 ccggttttgc gaacgcgaca cccggacatc ttttcatgtt gctaatcggt ctcttcttta
     3661 tctaccttgc cgtagccaaa gaatttgaac cgatgctgct gatccccatt ggcttcggta
     3721 ttctgatcgg taatattcca ttcaatatgg aagccggatt aaaagtgggt atttacgaag
     3781 aaggttcggt actgaacatc ctttatcaag gagtaacctc cggctggtat ccgccgctca
     3841 ttttcctggg tatcggagcc atgacggact tctcggcgct gatctccaac cccaaattga
     3901 tgctgatcgg agctgctgcg caattcggta tcttcggcgc gtatatcatt gccctgctca
     3961 ttgggttcga acccaaccag gcgggtgcta tcggtatcat tggcggtgcc gacggaccga
     4021 cggccatctt cctttcgtcc aaactggctc ccaacctgat gggtgccatc gctgtgtcag
     4081 cctattctta catggcgctg gtgccggtga tacagccacc tatcatgcgt gcgctaacca
     4141 ccaaacacga gcgtctgatc cgcatgaaac caccgagaat cgtatcgcat acggaaaaag
     4201 taatcttccc catcgtgggt ctgttgctta catgcttcct ggttccttcg ggtctgcctt
     4261 tgctgggtat gctgttcttc ggtaatcttc tgaaagaaag tggagtaacc cgtcgtttgg
     4321 caaatacggc cagtggtccg ttgatcgatg tgatcactat cctgttggga ctgactgtgg
     4381 gagcttctac ccaagcttca caattcctca cctgggattc tatcttgatc tttatcctcg
     4441 gtgcattctc tttcatcatc gcaacagcgt caggtgtcat gtttgtcaaa ttcttcaatt
     4501 tattcttgaa gaaaggcaat aagatcaatc cgctgatcgg taatgcaggt gtatccgccg
     4561 tacccgactc ggcacgtatt tcacaggtaa tcggtttgga atatgatccg accaactatc
     4621 tgctgatgca cgccatgggt cctaacgtag cgggggttat cggttcggct gtagctgccg
     4681 gtatcctgct cggattcctc atgtaaacga catttttttc attagtaaag tagacgtcct
     4741 tcttttcgca aagaagggcg tctttttttt gcgttaatct atctaaaaga tattacgaaa
     4801 ctttcgtaga atggatattt ttactaactt gcggacaata aaacaatacg tcctatgaga
     4861 acaagaacaa tgaaaccact cttccttatt ttctgtcttt gcctcagtcc cctactgatg
     4921 ggccagaatc aaaacaaaat tcaggaagca atggcaaact atgactacga gactgccgtt
     4981 gaactgataa acaaggaacc tcccaccatc ccactgttaa tgcagaaagc aaaagccctg
     5041 aaaggaatcg gcagcaatgc ggaagctcta cgttccatcc gccaagtgat agcggaagac
     5101 tccaccaacc aacaggcaca catcgaagca gcggaatgct gtaaagcaat ggccaagtac
     5161 aacgatgcgc tggactacta ccggaaagcc atcagcctga atcccaaaaa caagtatgcc
     5221 cgtttgcaat tcatcaacct gctttgcaac accaaaaact atgctgaggc ttttggagaa
     5281 agttcaatga tgtccgaaac ggacagttcg gccgtagtgc tccacctaca ggctcaaagc
     5341 cttgaaggga tgcaacagat actaccggct atcggttgct atgaagtcat tcaggataaa
     5401 tatccggacg attatctggc tgcggccaaa ctcggaaacc tgaacattgt agctggatat
     5461 cccgaatatg ccatccaagc taccgaacgc tatagggaac gggactccac caacctgatt
     5521 gtcaaccagc aaaacgctct cgcctactgc cacgccgaac aatatccgac agccatcaaa
     5581 cgctatgaaa agctgtgcca acagggggac agcagtacac agaccttata ctatctggga
     5641 gtcagctatt acgcggatga atattattac gaagcgcacg cgtgtttcag caaactgcaa
     5701 aaagagatgg aagaaaatcc caatctgctc tattatctgg gacgttgctg cgccaagact
     5761 tcctggaaaa aagaaggcat cgaacacctg gagaaagcta tcgaactgac cattcccaaa
     5821 gacagcacca tgatccgact ttacaaaggc ttggtggatt gttgtaaact ggctcaggat
     5881 actccaaagc aaatccaggc tctcagagaa ctgtacaaat atgacaagac gaaccataaa
     5941 cttctttatg acatcgcctg gaactattca tatcaactca aagacaacaa atcggccgaa
     6001 cgttatctgc aggctttctt aaaaacccga aaggcgaatg ctaggaaaga agaaccggtg
     6061 agtgagaaag gggaacttgt actcggactt gaaaattatt acaacgctgc cgaaaattgg
     6121 ctgaaagact tacagaaaga aaagttcttc aaagaaggaa taccgttaga aagtcagaaa
     6181 caatagaatc tatcccctca tgaaacattg gatactcctc ctctatctgg gcttcagcgt
     6241 aatgctgcga gcccagaaca ccgcctccgt tcaagaagca atggcaaact atgactataa
     6301 aacggtgatc agactgattg atgaagaaag tgcatcacca cagttactca tacagaaagc
     6361 caaagcttta aaaggtttag ggcgtaccgc cgaagccctg tccactttgc aacatatcat
     6421 tatcgagctg cccgaaaatc agcaggcatt ggtagaggca gcagaatgtt gcaggcaatt
     6481 gagcaaattt aacgaggcct tggggtatta tcggaaggtg atggaactca atcccgaaca
     6541 tatttacgca cacttgcaat acacccgctt gttatacaac tatcagcgat acggcgatgc
     6601 attgcgtgag agtatcgcat tggccaggaa agacagttcc gccaccgtat tgcgactgat
     6661 ggcggaaagc atggaaggag ccggcatgcc ggtagaaagt atgttttgct atctttccat
     6721 catcaggaaa tatccctccg actatctctc ggtagctaag ctgggcagta tcttcaatac
     6781 aatgaaagat tacgaagggg caattgccct gacagaagca taccgccgga cggacagcac
     6841 caatgtagaa gtgaaccgtc aaaacgcact ggcgtattgt ctgcgcaaag aatatcccac
     6901 cgccatcaaa cgttatcagg atctgaccgc ccggggagac agcacactgc tgacatgtta
     6961 ttacctggga gtcagctact acgctacgaa agaatactat aaagcgcgcg attggctact
     7021 caaagcaaaa tcatgccagt cacccggcgc caacctactc tactatttgg gacgttcgtg
     7081 ctccaagaca ttatggaaac aagagggaat aggatatctg aaccaggcta tcgccctgac
     7141 tatccccgcc gacagtatca tggagcgctt atactcaggc ttggcagact gctacaggca
     7201 aaccaagcaa acccgggacc aaatcaaggc taccaaagaa caatacaaat atgcccctga
     7261 caagcatatt ttactttata acttggcgtt cttatcggac aaaataggag atactaaagc
     7321 cacagagcat tacttgcagg cttttctgcg aacaaaatcc aaacaaaatg cagtactaca
     7381 gcagccggat gatgacgaag aagaacccgc accctacata gattactaca aaagtgccac
     7441 caataaattg gaaagcatcc gaaaagagaa attcttaaag ggagaaaagt gaattgatcg
     7501 gatagatgca tcgtttcgga caattcacca ctgagtgcag acagagtttc acagagggag
     7561 aataatggaa aataaatttg aagatgtgcg gtagaaggca cagtagcacg taaccgaagt
     7621 cacatcggca cgcagccgaa attacggtgc tgtgtagcta aagttacggt gctgcgtagc
     7681 cgaagttacg gtgctgcgta gataaagtta cggtgctgcg taatcaaagt tacggtgctg
     7741 cgtaatcaaa gttacgatgc tgcgtagccg aagttacggt gctgcgtagc cgaagctatg
     7801 acggcatctc cttttccgga cgtcacgttc acctgattgc atcgaaaagt gctccttatc
     7861 ggttgagctc catcccggag aattctccaa tgaaaacgtt tgcataaata gatggcacac
     7921 agtaagaaag aaaacggaaa acaatccgat gatttaccct atattagcaa cattaaataa
     7981 taacgagcta atatcatgaa aaaattattg ttactcttag gttcattcct actgtcatta
     8041 accacttatg cagccatgaa catatccaaa atcgatccgc ccttctggtt caccggtatg
     8101 aacaatccgg aactccagtt aatggtatac ggtgaaggca tcggccaggc atccgtatca
     8161 gtaaattatc ccggtgtatc gctcagcagc atcgtgaaac tggaaagcaa caattacctg
     8221 cttgtctacc tacatctcga taaagaagta aagccgggca agatgcccat cacatttacg
     8281 gtcggaaaga agaaattggt gaaagagtac gaattgaaag cacgcagcaa agccggagtc
     8341 gatcacaaag gttttgacgc atcggatgca ttatatctgc tgatgccgga ccgttttgcc
     8401 aatggcaatc cggataacga ccagatagaa ggcatggccg aatataaagt ggaccgcaac
     8461 gacccgaacg cacgtcacgg aggcgacctg gccggtatcg aacaaaatct ggactatttt
     8521 accgacttgg gagtcaccgc actctggttc accccggtac tcgaaaataa tatgaaaggc
     8581 ggctcatatc acggatatgc aacaaccgat tattacaagg tagacccacg tttcggcact
     8641 aacgaggaat atcgctcact gatagcgaaa gcccacaacc ggggcattaa ggtcgtgatg
     8701 gacatgatct tcaatcattg cggagtagaa catccctgga tcaaggacat gccttcaaag
     8761 gactggttca accatgcgga cttcaagaac aactttgtgc aaacttccta caagctgact
     8821 ccacatgtag atccgtatgc ctcggagtac gatttcgacc agatgaacaa cggctggttc
     8881 gtggaagcca tgcctgacct caaccaaaag aaccctcacg tatacaaata cctcttgcag
     8941 aacagcctgt ggtggattga gtacgccgat atcgacggca tccggatgga cacctacccg
     9001 tatgccgatt acgatgccat gagcaactgg atgaaagaac tgaacgaaga ataccccaac
     9061 tacaacacgg tgggcgaaac ctgggttacc gaaccggcct atacagcctg gtggcagaaa
     9121 gactccaagc tctccgcccc gcgcaacagt cacttgaaaa cagtcatgga tttcagcttc
     9181 ttcgacaaag tcaacacagc caagaatgaa caaacggaca cttggttcaa aggattggac
     9241 cgtgtctaca acaattttgt atacgattat ctgtatccca atccggcttc cgtactggct
     9301 ttcatcgaga atcatgacac cgaccgtttc ctgggtgaag gcgaaaacct cgatatgctg
     9361 aaacaggcct ccaccctttt attgaccacc cgacgcatcc cgcaactcta ttatggaacg
     9421 gaggtgatga tgaacggagt aaagagtaaa agcgacggct atgtacgaaa ggacttcccg
     9481 ggcggatggg cggacgataa agagaatgcc ctgactcccg agggacgtac ccgattgcag
     9541 aatgaaagct ataacttcta ccgcaacctg ctgaactggc gtaagggcaa cgatgtgatc
     9601 gccaaaggca gcatgaaaca gttcatggta cagcacggcg tatatgctta tgcacgccaa
     9661 tataaaggga aaacggtctt cgtcctgttg aacggtacgg ataaagaggt gaaacttccc
     9721 ctgaaatact atgccgaagt gctgaaagac aagactcaag gaaaagacgt cattagcgga
     9781 aaagtaacgg cactcaatga agaactgaca atggcacccc gccaatcgat ggttatagag
     9841 ctttaatctc acaccggtta taaccgcata agcaaagggc acaaaggatt tcacccgaca
     9901 tcctctgtgc cctttgtgta gcctaatgcg aataataata gtcaaacgtt tgactattat
     9961 cgaagaatat tcctaccttt gcaccgacta aaagaatacg acgatgacaa acaacgaatc
    10021 ggagcgcgag ctcgtcctac aaaccttacg aacctggatg gcattccgcc aggccgttca
    10081 gcgggtactc aaacgtcaca acgtggatat gaccttcgag atgctgcaag taatgaactg
    10141 cctgtggaac aaacaaggca tcagccagca atccctggct gagaaaacag caaaggacaa
    10201 ggcttgcctg accaatctga ttaataatct ggaaaagaaa aactgggtga tacggaaaga
    10261 aggcccctcc gaccgccgaa accgcctgat tttcctgacg ccccaaggcg aagaacttgc
    10321 cctcaccgtg aaacccctga tcaacgatat ctatgcccaa accggaacag agatggaggc
    10381 aagccggata acggaatgca tcgaagatct gaagagactg catgaagtgc tcaatgagat
    10441 ctaaaagaaa tccgccatgt ccacccatca gataaagcta aaacaattga gaagactgaa
    10501 gttcaggaac atctttctca acacagtatg catcctgctg gcattggcag gtatttcatg
    10561 gacagtaaac tacttctgga aatacgcccg ctacgagata accaatgatg ccgtagtgga
    10621 tcaatacatc gctccgctaa acatccggat accgggctat atcaaagaag tacgttttac
    10681 cgaacaccag tatgttcatg ccggcgacac gttactgata ctggacgacc gggaataccg
    10741 gatccggctg aaagacgcgg aagcggcctt gatggatgcc ttgggatcaa aggaagtgtt
    10801 aaactccggc atccggactt caggagtaaa tgtagccgta caagaagcca acatagccga
    10861 aacactggca cgcctttcac agcaagaagc ggaactgaac cgatataccc ggctcttgaa
    10921 aaagcaggcc gtcagccaac aggattatga actggccaaa gcgaacttcg aagcgacccg
    10981 ggcaagatac aacgccctgt tgcgacaaaa agaagcggcc caatcgcagt attccgaaac
    11041 cagcaaacgc agtacaggcg ccgaagccaa tatcctccgg aaggaggccg acctggagat
    11101 ggcccgacta aacctgtcgt ataccgttgt caccgcaccc tatgacggat acacgggacg
    11161 acgtacactt gaaccgggac agttcgtaca aggcggacaa actctttcct acctggtacg
    11221 gggcaatgac aagtgggtga cagccaatta taaagagact caaatagccc atatctatat
    11281 cgggcaaaaa gtccgcatca aagtagatgc tttcagcgga cgcacttttc acgggaccgt
    11341 aaccgccatt tccgaagcca ccggatcgaa atactccctg gtaccgaccg acaattcggc
    11401 agggaacttc gtcaaagtgc agcaacgcat tccggtccgc atcgatctca atgacgcctc
    11461 acccgaagag atggaatgtc tccgtgcagg gatgatggta gaaacggaag cggtccgccc
    11521 ttaggcttat ggtgaagctc aatctgccta cccgtccctg ggtgcctcaa tggttgggca
    11581 tcgtgaccat gtttattgtc atctttccca tcaccctgct caacggtgcc tacacaggaa
    11641 gtatggtcga agtatcgaac acgctgggag tattgagcga agatattacc atggcttact
    11701 attcagcttc ggtagggatg gctgttgcct atcccatcgt accgaaaata cgcaccatag
    11761 ccactccgaa aaccttactg cttaccgacc tgctgctaca gatattcttc agcctggtat
    11821 gcgccaaaac cggtagtatg gacgtcatca tggtatgcag tttctgtatg ggatttctca
    11881 aagccttcgt catgttggag ttcatcatcc tgatccgccc gctcttcagt ccgaaaaacg
    11941 tacgaagtga attctatgcc tacttctacc ccatcgtttt ctccggaggt cagctatcga
    12001 tggctatcac cgctcaactg gcctatcact accaatggca gcacatgtac tattttgtca
    12061 ccatcctctt gctgatcgcc attctgttcg tcatctgttt cttccgctat gcaaggcgtc
    12121 ccatgcacat tccgttcaaa gagatggacg gaagaagcat gttcatcatc gccaccgctt
    12181 tcctgctaac gctctataca tttacctacg ggaaaacact cgattggttc gcatccccga
    12241 agatcagagt atatgtattc gtcatcccgc tcctgatagc tctcttcatc catcggcagc
    12301 gtacacaagg caaacccttt gtcagcctga aaccactctt tctgcataaa tccatcatcg
    12361 gatatggctt catggtactc gccatgttcc tgacagccac cagttcactg gtaaccaact
    12421 atatgaacag catcatccga gtagacagca tacacgccaa ttcgctgagc ctgtggctat
    12481 tgcccggata tgtggtagga gccgtcattt gcttctggtg gttccgatgg caacgatggc
    12541 ggtttcgctt cctcatttca ggaggtatgt tctgctacgt catctatctg gctatcctct
    12601 actttggtat caccccttat ggaacctatg aaatgctcta cctccccatc ctgttccggg
    12661 gagtggggat gatggtcata ttcattgcgt tcggtgtgtt tgttgtcgaa gatttagacc
    12721 cgcgcctgac gttgtccaat gccttcttcc tgatttcatt ccgctcagta ttggctccgg
    12781 tcctgtccgc ttcgttcttt aacaacatgc tttactatct gcaggcaaag gggatgaaca
    12841 ttctttcgga aaacatgacg ctgaccaatc cgctggccga acaaaaatac aatcaggcat
    12901 tgagcaatgc cctgacgcaa gggcacgaat tcggcgaggc cggacaattg gcagccaaca
    12961 gcctgtactc cactttgcag cagcaatccc tgctgcttgc cctgaaaacc ctaatcggct
    13021 atgtactgat actggcactg gtgattgctg tcttcgcagc gttcattcct ttccataaaa
    13081 cgctgaaggt ggctgtagtg aagacgggtg acgatatggt ataatgagaa gggatacaaa
    13141 aaagccaccc aattgcttga gtggcttctt aaaatataaa ttaaatcaag taaaactttt
    13201 aaatactaga tttggaattt attcagctaa cttgttgtca gaacccagca cgttgataat
    13261 tttgtgcttg tagagttttt ccatattgtc gcgagccggt cccagatatt tacgcgggtc
    13321 gaactcagcc ggtttttctg cgaatacctt acggatagca gcagtcatag ccaggcgaga
    13381 gtctgagtcg atgttgatct tgcaaacagc agacttagcg gctttacgca gttcctcttc
    13441 aggaataccg atagcagctt tcagtgcacc accaaactgg ttgatagttg caacctcttc
    13501 ttcaggaact gaagatgatc cgtgaagaac gatagggaat cccggaagtt ctttcattac
    13561 accgtccaat acgtcgaatg ccaacggagg aggaaccata cggcctgtct tcggatcgat
    13621 gtggcactgt tccggagtaa atttgtaagc accgtgagaa gtaccgatag agatagccaa
    13681 tgaatcgcaa cctgtcttgg taacgaaatc aactacttcg tccggttcag tatatgtgtg
    13741 gtggtcagaa gaaacttcgt cttctacacc tgccaatacg ccaagttcac cttctacagt
    13801 tacatcgaac tggtgagcgt attcaacaac tttcttagtc agagcaacgt tttcgtcgta
    13861 aggaaggtga gaaccgtcga tcattacaga agagaagcct gagtcgatac agcttttgca
    13921 agtttcgaaa gtatctccgt ggtcgaggtg caaaacgatt tcaggatttt tgcagccgag
    13981 ttcttttgca tattctacag caccctgagc catgtaacgc agtaatgtag cgttagcata
    14041 ttgacgagca ccttttgata cctgcaaaat aaccggagac ttagtttcta cagcagcctt
    14101 gatgatagcc tgcatctgtt ccatattgtt gaagttgaat gcagggattg catatccacc
    14161 cttgatagcc ttagcaaaca tatctctagt gtttaccaga cctaaatctt tgtaattaac
    14221 cattttgttt aaaagtttat tgttagtgaa ttaaaaattc tatgcaaaag taagaataat
    14281 cctttgaata gagaaaccct cgggcggaaa tatccgtttg aggagcgtaa ttcaattcta
    14341 tttcaaatta tttcccatcc tttaagagct gtttgtaatg tctacgtagc aaataaaggt
    14401 tttttattgt ttcctcatat atataatggt aggcaaatga tcgctgtaac catccaacca
    14461 cactctgcca ccatatgtac gcaggggtgc acccttatat ttaccatcct gctgaaacag
    14521 gtaatcgcgc atgaaaactt cattgtgatc atatttcaat ccttttgttg cttgaagcag
    14581 agtggatgaa aggatgatct gatcgaacag attccatttg ccgcgataga gcaaagtgcc
    14641 cactccctta tcttccagcg tcacccacca ggggttgtaa aggtcatctt cagtcatatc
    14701 ttcgac
//
