LOCUS       gnlProkkaMCIBAJIN_75   14469 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|MCIBAJIN_75.
ACCESSION   gnlProkkaMCIBAJIN_75
VERSION     gnlProkkaMCIBAJIN_75
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 00:10:18
            Original ID  :: gnl|Prokka|MCIBAJIN_75
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 73414
            Orig. end    :: 87883
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14469
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:14272]"
                     /cutoff="20000"
                     /detection_rule="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14272
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     cand_cluster    1..14469
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14469
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="((LANC_like and (Lant_dehydr_N or Lant_dehydr_C))
                     and not (YcaO or TIGR03604))"
                     /tool="antismash"
     CDS             156..1190
                     /locus_tag="ctg64_60"
                     /transl_table=11
                     /translation="MRRSILDIFLFLLVIISTAACNNDLPFDLKENPPKLVMNAIINAD
                     STYNTLFLNLTGRNQIGQIKGATVEVRINGSLSETLRPDPHSSDKGRFYINSAFHPGDV
                     VRIDAMTDDGEHHAWAEVTVPQPIGKIEKVDTASIMRKPSNYGYGTPPRRHLRYQIKIK
                     DRPGEKNFYRIIVEQRKYWKYYWEQNDQTCWSSAMQKSFKLQTNEDVVLTDGKPSTEED
                     DENGLFGTVNNKYAIFDDSRFTDGSYTMNVYNDIYGWGFWGQEYIWIKTDVYIRILSIT
                     EKEYYYLRALNLLDSDAYDNTLSEPIAFPSNVNGGTGMVGFSTETNYMLTVKNNAVPPM
                     VPDL"
     CDS             1228..1515
                     /locus_tag="ctg64_61"
                     /transl_table=11
                     /translation="MFIIIGIMLTGMLLGYLLRSKRLTWIHKVITLLIWLLLFLLGIDV
                     GGNEAIVKGLHAIGLEALIITAAAVTGSTLAAWGLWYLLHTRYQKKEAKP"
     CDS             1512..2114
                     /locus_tag="ctg64_62"
                     /transl_table=11
                     /translation="MKGSLIIVSFFIVGTLCGLLQLIPYDFSQSKLSFYALCGLMFCVG
                     ISIGNDPQTLKSFRSLNPRLLFLPVMTILGTLAGCAVVSLFLSHRSPSDCMAVGSGFGY
                     YSLSSIFITEYKGAELGTIALLSNIMREIIALLCAPLLVKFFGKLAPISVGGATTMDTT
                     LPIITRCSGQEFVIVSIFHGFIVDFSVPFLVTLFCSI"
     CDS             2379..2732
                     /locus_tag="ctg64_63"
                     /transl_table=11
                     /translation="MKRLGLTLVAALCLVATTFAAGNQPTVAKWEGNINVNKLGKYLNL
                     SSVQAEEVANICNYFDEQMGRATTAKKNKDTMVRNAVYGNLKLMKKTLTDAQYTKYTTI
                     LNMTLKNKGIEVK"
     CDS             complement(2906..4021)
                     /locus_tag="ctg64_64"
                     /transl_table=11
                     /translation="MATKIKLNDCVPCIAIHPGEIIKDELDAREMKQKELASLMSMPTS
                     VLNDIIKGRRAVTPEVAVLLQEILGIDASYWLSLQNQYDIDRANINKKIVERKKNIEIW
                     KVISQYCSVKYFEKLNVIGTKISENIKIIYSIFGVTSVEELIASFSSEKELSYFKKSER
                     LKSDPINIFSWKHFAFYQSSQMLDVADFDENSLERLVQELNQMFVVNINTIDKTKEILS
                     RYGIKFIIVPKFDKTPIDGFSFWQGKNPTIVLTLRLNKIDNYAFALLHEIYHVYMHLFN
                     NREQKYIAIEGAEINKCEEEANKFAKCSLIGKDLWNTFLKQHSMISPHAMQMKIKQFAH
                     QHNINEAIVLGFYQHDINLYSIKSSISREIK"
     CDS             complement(4011..4334)
                     /locus_tag="ctg64_65"
                     /transl_table=11
                     /translation="MNIYTEDEALIELLEEGCTNDKRYKRLPKDVIKGYIKAYNHLKAA
                     TRIEDLFRIGSLHYERLKGDLKDFESVRCTGRWRLIFQSSTIDGSLIITEIELIEISNH
                     YGD"
     CDS             complement(4638..5768)
                     /locus_tag="ctg64_66"
                     /transl_table=11
                     /translation="MAVINPFVVGGYVSPRYFCDRVAETENLIRNLINGRNVALVSTRR
                     MGKTGLIRHCFYQPLIKEGYYTFFIDIYATSSLKEFVFALGKGIFEKLKPQGNKFIDRF
                     FSIITSLRIGFKLDSITGEPILELGLGDIHAPETTLEEIFIYLEQADKPCIVAIDEFQQ
                     ISSYPEKNLEAILRTKVQHCSNSNFVFAGSQRHIMMNIFNSPSRPFYQSVSMMHLGAIP
                     LEVYKPFVKGLFEENGKKVTDQLVENVYTLFDGHTWYVQLMLNELFILTDKKGICDVPM
                     INLALNNIIATQDFTFQEIFSRLPEKQKEIMIAIAKEQKAKGVTSAAFIKKYRLTSASS
                     VQSGLKGLLEKDMLTQESGGYQVYDRLFNIWLRRNY"
     CDS             complement(5809..6765)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_4"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg64_67"
                     /sec_met_domain="Glycos_transf_4 (E-value: 2.8e-29,
                     bitscore: 94.4, seeds: 116, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MCYLLILVLLFLAELFYFRIADKCNIIDKPNERSSHTRITLRGGG
                     IIFYLGALTFFLTNQFEYPWFILALTLITFISFIDDIRSTSHGLRLVFHFTVMALMFYQ
                     WGLFSLPWWTLLVALIVCTGIINAYNFMDGINGITGGDSLVILVSLAYVNAEVISFTEQ
                     SFIYTMICSVLVFDFFNFRKRAKCFAGDVGSVSIAFVVLFLIGSLILQTKDFSWLVMLT
                     VYGVDSVLTIIHRLLLHENIGLPHRKHLYQIMVNELRIPHVVVSLVYMIVQIVIIIGYL
                     YCRGYGDWYLLGCILLLSGIYIVLMRKYFHLHLLPKR"
     CDS             8055..8618
                     /locus_tag="ctg64_68"
                     /transl_table=11
                     /translation="MAQLESKQLNKIGLHENATNRNMDEKLLLKCENSIRAYKIVNLLN
                     KHNIALRQHDESQDPRVGAYGAVTGIAIYVFAKDYEKALSIVSPILKDFNTISTFCPKC
                     GSENVKPITGNHKYITYLIFLCLFLILTPGIYIALPEDFGLRSSLINKIALMMVVLGFI
                     LMPIINHYNVNYKCKKCGNRFRHY"
     CDS             8956..10029
                     /NRPS_PKS="Domain: PKS_ER (37-232). E-value: 7.6e-21.
                     Score: 66.4. Matches aSDomain:
                     nrpspksdomains_ctg64_69_PKS_ER.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028:crotonyl-CoA reductase / alcohol dehydrogenase
                     (Score: 105.6; E-value: 4.9e-32)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg64_69"
                     /sec_met_domain="ADH_N (E-value: 4.5e-08, bitscore: 25.2,
                     seeds: 66, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNIIVCDSNINKKDIEGYKVVIDGYEYLFALLDIPVNKYTDKIS
                     DQSVVVRVSAFSCNYRDKGILYNFLKKCKDYNLKESYYYSFLGSEFVGKVIKIGRNVRS
                     FKIGDRVMSDNSYPFKVDGKIGGIVSNYASKRIQIFHESCLIKVPDSMSDIEAAAFSLT
                     ASTAHSMVSKSKLKEGDKVLVTSLFSNTSLGCLELLKNISGIKIYGLTTGYKEAQSLSE
                     KFKIQKIFTPDDFYTATNKMNINFNVIIDPFPDIHINYLHSYLNYSSRYISCGMSSHQN
                     EKIDFHKILYSLIVSNSQFIGNCLGLPYDLKAVINEYSHERYKVYVDSVYTGRQISDFI
                     NKSFNERHFGKVVYSYE"
     aSDomain        9067..9651
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg64_69_PKS_ER.1"
                     /evalue="7.60E-21"
                     /label="ctg64_69_PKS_ER.1"
                     /locus_tag="ctg64_69"
                     /protein_end="232"
                     /protein_start="37"
                     /score="66.4"
                     /tool="antismash"
                     /translation="NKYTDKISDQSVVVRVSAFSCNYRDKGILYNFLKKCKDYNLKESY
                     YYSFLGSEFVGKVIKIGRNVRSFKIGDRVMSDNSYPFKVDGKIGGIVSNYASKRIQIFH
                     ESCLIKVPDSMSDIEAAAFSLTASTAHSMVSKSKLKEGDKVLVTSLFSNTSLGCLELLK
                     NISGIKIYGLTTGYKEAQSLSEKFKIQKIFTP"
     CDS             10001..11245
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140:Lanthionine synthetase C family protein (Score:
                     198.9; E-value: 2.2e-60)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg64_70"
                     /sec_met_domain="LANC_like (E-value: 3.8e-40, bitscore:
                     129.9, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKLYILMNSLNINVCKVMKRKTLIEEDKKKIEISNKIDEIYLIM
                     KENVHCNNWGVLDGFSSTILFLSRLYIYSKDDKILDDLYNRINLLISYLDKIKLPTICG
                     GYAGICWLFRYLYKEKLVESNNINEVLDGLEKYITKTFYNYYINDTDFLHGGLGIAFYF
                     LLSDTNYSENLCKVYLDRLDKNKQNQKDGSCMWTTQVYNGGENEAVANLSLSHGMASII
                     IFLAYYHSKTNNPKAKRLLQQAIEFYKRNTNPNNFYSMYSNWIKINSPSNLSESRLAWC
                     YGDLGIAKALNYAGVSLGNSDITNFSFEVLNKTIPRFMNSHVEDASFCHGSSGISHIYN
                     HFYQITGYDAYKNSAIFWLNDTLNRIKYLEVNSSFSTELNDVCSILTGLSGVGLSLLSS
                     IEDKEDNWNELLLLL"
     CDS             11262..13418
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155:Lantibiotic dehydratase domain protein (Score:
                     400.1; E-value: 2.9e-121)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg64_71"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.6e-123,
                     bitscore: 405.2, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 7.8e-10,
                     bitscore: 31.6, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKYIPYNQCIIRTPLFPINYIDKIEDFELSIFQQSFKEAVYIAT
                     PVLYQELYIKNNINERTINSAIKYYVRSCTRCTPYGIFAGCDIVPIRIDDNYSNIIMSD
                     LKNYKTYTRIDMNYLCELIRKLDLMPQIQNAITYHVNTTSYFLGKNLRYIEYRINKSKR
                     NYTFSEISHTPYLNNIIKALKKTPLTKKEIIRLLIKNKEIEEEEALNFVQTLIDEQILI
                     SNLEPSVVGEDLIQQLHHNLSEINYNLEFINSLIYLLKECDKESLGNKESIINNIYRLL
                     SDGMLFEQDTLMQVDTLNKVKQGIIGNNITKVIDKCIYFFSKFQPSHKSETFELFKRRF
                     YEKYEEQEVPLVVALDPQVGIGYGNWTENNGDINPLLQGLPNPFLDRSYKIDMDLTPVT
                     MLLIKKYEEAIKQGLHEIEILDEDLNEFEERDLKLPQCSVMLSVLSNDDTPSILLKGII
                     GGATSRLISRFEYLDSKIENFVNEINKRDELYYKDCIVAEVMHLPEDRIGNIQMHPNNR
                     QYGICYLSSPTTKYVKKIIPIDDITISVYHGQEVILKSKKNKKRIIPMLSTAHNTKNGL
                     PIYSFLSDYINQESMSYSFDWGSYFHNKSFLPRVIYSNVILKPARWLIHPNEFPQNKNL
                     NSDELYSWKLKQRIPDEILITLGDNQLYINFNKEHLVKIFISELKKKRPIILEEFLYSS
                     KNINLVESQEGFFANELIINLYKK"
     CDS             13415..14272
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg64_72"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.5e-35, bitscore:
                     114.7, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQRIFIIGGEWIYFKIYSGPKTIENIFINDIMCKINLLIKQRMI
                     DSFFFVRYMDPNYHIRLRLHCTNINNYAFILHLIYKTLNRYVKDLIITKVQLDTYTREL
                     ERYEYNEIVHFETFFYYDSCLITKCLKRLNCTDQDRYKISMKFIDSIMDICNFSLDEKI
                     NFTEKNSKAYFLELYQSDCTIGHILNLKYRKYRNEIEKCLNDESKHCWWNKEIKKNIYI
                     MRTIPLNILTGKNNKLSSIIHMHVNRMYRINQRTVELVIYSLSTDKTYILPNHIYICLT
                     NNVL"
ORIGIN
        1 atgccatgaa ccccactctg atatatcgca cctacaaaaa gactgaatat actcaaggcg
       61 aacaagcaca aggcaaccgc ataccggtca ttcggaaatt cactctgttg ccttgcattc
      121 cttcattcag ttatacatat aaattctaag tatttatgag acgatcaatt cttgatatat
      181 tccttttctt gctggttatc atatccactg cggcatgcaa taacgatctt cctttcgact
      241 tgaaggagaa tccgcccaag ttagtgatga atgccattat caacgccgac agcacctaca
      301 acaccttgtt tctgaacctc accggcagaa accagatcgg acaaataaaa ggagccaccg
      361 tagaagtacg catcaacggt tctctcagtg aaactctccg tcccgatccg catagcagcg
      421 ataaagggcg cttttatata aacagtgctt tccatccggg cgatgtggtc cgtatagatg
      481 ctatgacgga tgacggcgaa caccacgcat gggccgaagt caccgtacct caacccatcg
      541 ggaagataga aaaagtggat acggcctcca tcatgagaaa gccgagtaac tatggctacg
      601 gaactccgcc aagacgacat ctccgttacc aaatcaaaat caaggaccgc ccgggagaga
      661 agaattttta tcggatcatt gtggaacaac ggaaatactg gaaatactat tgggaacaaa
      721 atgaccagac ctgttggagt tcggcaatgc agaaaagctt taaactgcaa acaaacgaag
      781 acgtggtgtt gaccgacggc aaacccagta cggaagaaga tgatgaaaac ggactgttcg
      841 gcactgtcaa taacaagtat gccatatttg acgactcacg tttcaccgac ggaagttata
      901 cgatgaacgt ctataacgat atctacggat ggggattctg gggacaggag tatatctgga
      961 taaagacgga tgtctacatc cgcatactca gcattaccga aaaagaatat tattatttaa
     1021 gagcgttgaa tctgctcgac tccgatgcct acgacaacac cctgagcgag cctatcgctt
     1081 tcccaagcaa tgtgaacgga ggtaccggaa tggtagggtt cagtacagaa acaaactata
     1141 tgctgacagt taaaaacaac gcagttcccc caatggtacc ggatttataa agaaaccact
     1201 atctttgtgc cctaaaaaca catttatatg tttataatta tcggaatcat gctcacgggc
     1261 atgctactgg gttacctgtt acgtagcaaa aggctcacgt ggatacataa agtcatcaca
     1321 ttattaatat ggctgttgct cttcctgctc ggcatcgatg taggaggcaa cgaagccatc
     1381 gtgaaaggat tgcatgccat cgggctggaa gctctcatca tcacggcagc tgccgtaacc
     1441 ggaagcacac tggctgcctg gggactttgg tatctgctcc atacacgcta tcagaaaaag
     1501 gaggctaaac catgaaaggc agtctcatta tcgtctcttt cttcattgtc ggcactctgt
     1561 gcggacttct tcagttgatc ccgtacgatt tcagccaaag taaactcagt ttttatgcct
     1621 tatgcgggct gatgttctgc gtcggcatta gcataggcaa cgatccgcag acactgaaaa
     1681 gtttccggtc actgaatccc cgcctactct tcctgcccgt catgaccatt ctgggaacat
     1741 tggctggatg tgccgtagtc agcctctttt tgtcccatcg ttcaccgtcc gattgtatgg
     1801 cggtaggttc cggattcggg tattattcac tctcaagtat attcatcacc gagtacaaag
     1861 gagccgaatt gggtaccatc gcattgcttt caaacatcat gcgcgaaatc atcgctttgc
     1921 tttgtgcccc cctattggta aagttcttcg gaaaactagc acccatttca gtcggaggag
     1981 ccaccaccat ggacacgact cttcccatta tcacccgttg ttccggacag gaatttgtca
     2041 tcgtctccat tttccatgga ttcattgtag actttagcgt accgtttctg gtgacattat
     2101 tctgttccat ataggcatca tattacaaaa cgatttcatt tttctctaat atcccatctt
     2161 ttttacagca tatttttgat atacatcaag aaatgatatc attctgccca cttttctttc
     2221 tttgcgcttt tatgttgaat aacatatttg tatatttgca taggtaaaaa gaaaaagcta
     2281 agcgcttagc aattgttttt aataggtatt agggtcctta tgacaaggat aaggacaaag
     2341 attagttttc aggaataaca attaaaaaag taggtattat gaaaagatta ggattaacat
     2401 tagtggcagc gctatgcctt gttgctacta catttgcagc aggcaatcaa cctacagttg
     2461 caaaatggga aggtaacatc aatgtgaata aattgggtaa atacctgaat ttatcttctg
     2521 tacaggcaga agaagtagcc aacatttgca actattttga cgaacagatg ggaagagcca
     2581 ccactgcgaa aaagaacaag gataccatgg ttcgtaacgc tgtttacggc aatctgaaat
     2641 tgatgaaaaa gacgttgaca gatgctcagt acactaagta tactacaata ttgaacatga
     2701 ctttgaagaa caaaggcatc gaagtaaagt aggaacttga ttgatgaata aaaggataaa
     2761 agaccggtgt cgtcgaatga actgacatcg gtcttttatt tttatgccaa tcactgacaa
     2821 agatggttaa cactgatgtt tccggttaaa tcagtaattc ctcctaagcc agatattgaa
     2881 aagtctatca tacacctgat accctctatt ttatctctct tgatattgag cttttaatag
     2941 aatacaaatt aatatcatgc tgataaaatc ctaaaacaat agcctcattg atattatgtt
     3001 gatgagcaaa ttgttttatt ttcatttgca ttgcatgtgg agatatcatg gaatgttgtt
     3061 tgaggaatgt attccataag tctttaccaa ttaaagaaca cttggcgaat ttatttgctt
     3121 cttcctcgca tttatttatt tcagctcctt ctatggcaat atatttctgt tctctattgt
     3181 tgaaaagatg catataaaca tggtatatct catgcaataa agcgaaagca taattatcaa
     3241 ttttgtttaa tcgtaatgtt aatacaatgg ttggattttt tccttgccaa aaagaaaatc
     3301 catcaatcgg tgtcttgtcg aatttaggca ctatgataaa tttaattcca tatcgtgata
     3361 gaatttcttt tgtcttatca atagtgttta tgtttacaac aaacatttga ttcaattcct
     3421 gcacaagcct ttctaaactg ttttcatcaa aatcggcaac atccagcatt tgtgaacttt
     3481 gatagaaagc aaaatgtttc catgagaaaa tgttaatggg gtcactcttt aaccgttcag
     3541 atttcttaaa ataagaaagt tccttttctg aagaaaacga agctattagt tcttcaactg
     3601 aagttacacc gaaaattgaa tatattattt ttatgttttc tgatattttc gttccaataa
     3661 catttaattt ctcgaaatat ttaacagaac aatattgaga aattactttc catatctcaa
     3721 tattcttttt tcgttctact attttcttat ttatatttgc tcggtctata tcatattgat
     3781 tttgtaatga taaccaatat gaagcatcta ttcctaaaat ttcctgtagc aaaacagcaa
     3841 cttcaggagt tacagcacga cgtcccttta taatatcatt gagtactgaa gtaggcatgc
     3901 tcataagtga agccaactct ttttgcttca tttctcttgc atccaattca tccttaatga
     3961 tttcacccgg atgaatggct atacaaggta cgcaatcgtt taatttaatt ttagtcgcca
     4021 taatggttgg atatttctat taattctatt tcagtaatta tcaatgaacc gtctattgtg
     4081 gagctttgaa atattaatct ccaccgtccg gtacatctaa ccgattcaaa gtcttttaag
     4141 tctcctttca atcgttcata atgcagactt ccgattctga ataaatcttc tattcttgtg
     4201 gctgctttta aatgattata tgcttttata taacctttga ttacatcctt aggaagtctc
     4261 ttgtatcttt tgtcgttggt gcaaccctct tccaacaact caattagtgc ttcatcttct
     4321 gtatagatat tcatgcaatt cgttatcttt ctgcaaagat aaggatttta ttcttttcga
     4381 taatatatac cataaaataa attatcaaat ttgataatta cgcaatatcg tttctcaaaa
     4441 aaaaacaata agaaaggata tattgtttcg tgaaaaacaa cttttcaaaa ttattagtat
     4501 ataaatgatt ggcaaaccat ttaattcaat tcatatgctg catttattct caatacgtcc
     4561 ctgtccatcc tccaagttga ttatttcaaa cctgtcctct tccgcgaaga tggttaacac
     4621 tgatgtttcc ggttaaatca gtaattcctc ctaagccaga tattgaaaag tctatcatac
     4681 acctgatacc ctccagactc ctgagtcaac atgtcttttt ccagtaaacc cttcaacccc
     4741 gactgcaccg aactggcaga agtcaaccga tattttttaa taaatgcagc agaagtaact
     4801 ccttttgctt tctgctcctt ggcaatggca atcattatct ctttttgctt ttccggaaga
     4861 cgagaaaata tttcttgaaa agtaaagtct tgtgtagcaa ttatattgtt tagtgccaga
     4921 tttatcatag gtacatcaca gatacccttt ttgtctgtca aaataaaaag ttcattcaac
     4981 attaactgca cataccaagt gtgcccatca aacagggtat atacattctc taccaattga
     5041 tctgtcactt tcttaccatt ctcctcaaac aatcccttca caaaaggttt atatacctcc
     5101 aaaggaattg ctcctaagtg catcatactc acgctttgat aaaatggcct ggaaggactg
     5161 ttgaatatat tcatcattat atgcctttga cttcctgcaa aaacaaaatt agagttactg
     5221 caatgctgaa ctttagtcct taaaatagct tccagatttt tctccggata tgaactgatt
     5281 tgctgaaatt catctattgc tacaatacaa ggcttgtctg cctgctccag atagataaag
     5341 atttcttcta aagtagtttc aggagcatga atatctccca aaccaagttc taaaatcggt
     5401 tctcctgtaa tactatctaa tttaaatcca atccttaaag aggtaattat agaaaagaaa
     5461 cgatctatga atttattccc ctggggcttt aacttctcaa aaatcccttt acccaaagca
     5521 aaaacaaact ctttcaaact tgaagtcgca tatatatcaa taaagaaagt ataatagcct
     5581 tctttaatca aaggctgata aaaacaatgc cttatcaatc ccgtttttcc cattcggcga
     5641 gttgaaacaa gagccacatt tctcccattt atcaagttac ggatcaagtt ttctgtttca
     5701 gcaactctat cacaaaaata acgaggagaa acgtatcctc caactacaaa aggattaata
     5761 acagccataa caaaattatc atatttataa ttattgcaaa tataataatt atcttttagg
     5821 taaaagatgc aagtgaaaat atttgcgcat aagaacaata tatattccac tcagcaaaag
     5881 gatacagccc aataaatacc aatcaccata accccggcaa tataaatacc cgatgataat
     5941 cacaatttgc acaatcatat acaccaacga taccaccacg tgcggtattc tcaattcatt
     6001 aaccatgatc tgatacaaat gtttccggtg aggcaaacca atattttcat gtagcaacaa
     6061 ccggtgtatg attgtcaaca cactatccac tccatataca gtaagcatca caagccagct
     6121 gaaatctttc gtttgaagaa tcaaactccc gatcaggaac aggactacaa aagctatact
     6181 gaccgaaccc acatcaccgg cgaagcattt cgctctctta cggaaattaa agaagtcaaa
     6241 caccaacaca gaacaaatca tcgtataaat aaaactctgt tctgtgaagg agatcacttc
     6301 tgcattcaca tatgccaaag aaaccaggat aaccaatgaa tccccgccgg taatgccgtt
     6361 aataccatcc ataaagttat aggcattgat aatccccgta cagacgatca aagcgacaag
     6421 caacgtccac caaggcaagc tgaacaaccc ccattgatag aacatcaggg ccattaccgt
     6481 aaaatggaag actaaacgca aaccatgcga agtagaacgg atatcatcta taaaactgat
     6541 aaaagtgatc aaggtcaaag ccaatataaa ccaaggatat tcaaactgat tcgtcagaaa
     6601 aaaagttaat gcacccaaat agaagatgat tcctccacct ctcagagtaa tccgagtgtg
     6661 tgaactccgc tcgtttggct tatcgataat attgcattta tcagcaatac ggaaataaaa
     6721 aagttctgcc aggaatagca gaactaagat tagcagataa cacataaact attcgttctt
     6781 tttaatgaaa taaaaccaaa gttgaagtcc taaaaaggca aaagaaatac cccctattag
     6841 gagtcctata atcccccaaa aatccactca caatacctcc ttattctatc tgaaaattct
     6901 ccaaaacatt cataggtttc cacccaagtt cacgcatagc cttttcatta ctaagagtca
     6961 aagagtgcgt gatcttacga agttttaaac tgtttattgg ggcattttcc ccaagacaat
     7021 caccaaaaat ggccatactt ttagcaaaca ataaggaata gatattggtc tttttttatt
     7081 caattgctta catatcacca tctctaattc acgaaaactc agctggtaac tgtcacaaac
     7141 attatatatc cctccctttt caatcaatag aggaacaaga ttagttatat cctgaaccat
     7201 caaaacactt ttccgagctt ctcccccagc aatacttaag tacttaccat ttctaatccc
     7261 atgaatcatc gctcctaaat ttcccggagg attaggtccg gcaatttagg ctactattga
     7321 cggaacgata gattcagacg caatgctgaa taattactta tacgacttct tgtcgcacga
     7381 gatacctaaa gagacaaaaa atcaaatgat tttcaacaat ttgattatga gtaaattgta
     7441 aaattttata atattttctc ataactacgg tgttgcattg atactgttac actattggta
     7501 agtgatgtac ttcctagtaa ggctacacca ttggattaat tcttttattt gctcagaaag
     7561 agcgagaaaa atcttcagct taatctaata aatgattcct gtttgctgca gaaaaaattt
     7621 cttcctagta aagatggaac tcgaagaggt gtaatacaaa agaaaaaaat acaagaagca
     7681 taaaaagaaa gaaaagccta ttctcaaact tattgatccg cctttcctgt tggtagagga
     7741 gattcatctt agcatgaaaa agacaataga taaaaaacgg tattcagaaa gatcgttttg
     7801 ctaaaatcag aacgagtatt agttcttgcc tacaacttta aattttattt acagaataat
     7861 atattttaaa acaaaatcta agtaataatt ggaatatgaa ctataaaaat caatattctt
     7921 tttgtaacct gattttttcg taagatagac aaaagtgtta aattacgcaa aatacatcag
     7981 catatattta taatcaaatt tattttgact atattagaaa aatgttcctt caatctttaa
     8041 atataatatg aacaatggca cagttagaat ctaaacaatt aaacaaaatt ggtttacatg
     8101 agaatgctac caatagaaac atggatgaaa aattattatt aaagtgcgaa aatagtattc
     8161 gcgcttacaa aattgtgaat ttgctcaaca agcataatat tgcattacga cagcatgacg
     8221 agagtcagga tcctagggtt ggtgcatatg gcgccgtaac tggtattgct atatatgtat
     8281 ttgctaagga ttatgaaaag gctttatcta tagtttcccc tattcttaaa gattttaata
     8341 ccatcagtac attctgtcca aaatgtggaa gtgaaaatgt aaaacccatt actggtaatc
     8401 acaaatatat tacttattta attttccttt gcctgttcct tatacttact cctggtattt
     8461 atattgcttt gcctgaagat tttggactca ggtcttccct aataaataaa atagctttaa
     8521 tgatggttgt gctaggtttt attttaatgc caattattaa ccattataat gttaattata
     8581 agtgtaaaaa atgcggcaat agatttaggc attattagct ttattgttca taatcgattc
     8641 tattgtttta ttacaacaga atcaagttaa taaaaagaga ttgtcctata taataaatgt
     8701 ttttattatg aggtttaaaa ttccgactta tgtatacatc actatctatt tgaaataaat
     8761 ggaatgagga tctttcagtt atatattcta taagtattct atccattagg aatcattact
     8821 taaaaataaa aatatactta agtttgactc gtttttatcc aaaagtataa tagataggat
     8881 atatttctat ttttatagaa ctccaagaat gctgatttaa ttgagaaaat gtaaattgat
     8941 aaataaataa aaaacatgaa aaatataata gtctgtgatt ccaatataaa taaaaaagat
     9001 attgaaggtt ataaagtagt aattgatggt tacgagtatt tatttgcttt gcttgatatt
     9061 ccggtaaata aatacaccga caaaattagt gatcagtctg tagttgttag agttagtgct
     9121 ttttcatgta attacagaga taaaggaata ttgtacaact ttttaaaaaa atgcaaagat
     9181 tacaatttaa aagaatcata ttattattca tttctgggat ctgaatttgt gggtaaagtc
     9241 ataaaaatag gtaggaatgt gcggtctttt aaaattggtg atagagttat gtccgataat
     9301 agttatcctt ttaaggttga tggcaagatt ggtgggattg tcagcaatta cgcatcaaaa
     9361 cgtatacaaa tatttcatga atcatgtcta ataaaagttc ctgactctat gtctgatata
     9421 gaagcagctg ctttttcact gactgcttct accgctcatt ctatggtgtc taagtcaaaa
     9481 ttaaaagaag gggataaggt tctagtgaca tcattgttct ccaatacatc cttaggatgt
     9541 ttggaattac tcaaaaatat aagtgggata aaaatatatg gattaacaac tggatataaa
     9601 gaagctcaat cattatcgga aaaatttaaa attcaaaaga tattcacacc agatgacttt
     9661 tatactgcaa caaataaaat gaatatcaat tttaatgtga taatagatcc atttcctgac
     9721 atacatataa attatcttca ttcatattta aattattctt cacgatacat atcatgtgga
     9781 atgagttctc accaaaatga gaagatagat tttcataaaa ttttgtatag cctgatagta
     9841 tccaattccc aatttatagg gaattgccta ggattaccat atgatcttaa agctgtaatt
     9901 aatgagtaca gtcatgaacg gtataaagtg tatgtggact ctgtatacac tggaagacaa
     9961 atttctgatt ttataaataa atcctttaac gaaagacatt ttggaaaagt tgtatattct
    10021 tatgaatagt cttaacatta atgtatgtaa agttatgaaa agaaaaacat taattgaaga
    10081 agataagaaa aaaatagaaa tatctaataa aatagatgaa atatacctta ttatgaaaga
    10141 aaatgttcat tgtaataatt ggggagtttt agatggcttt tcgagtacta ttttatttct
    10201 gtcacgctta tacatctatt caaaagatga taagatattg gatgatttat acaatagaat
    10261 taatttatta atatcttatt tggataagat aaaacttcct actatatgtg gagggtatgc
    10321 tggaatatgt tggctattca gataccttta taaagaaaaa ttagttgaaa gcaataatat
    10381 taatgaggtc ttagatggac tagagaaata cataacgaaa acattttaca attactacat
    10441 aaatgataca gattttttac atggaggatt aggtattgca ttttattttt tactttctga
    10501 tacaaattat agcgaaaacc tttgtaaagt gtatttggat agacttgata aaaacaaaca
    10561 aaatcaaaaa gatggaagtt gtatgtggac aacacaagtt tacaatggag gagagaatga
    10621 agctgttgca aatcttagct tatctcatgg aatggcttca ataattatat ttcttgcata
    10681 ttatcatagc aaaacaaaca atcccaaagc caagagatta ttacagcaag caatagaatt
    10741 ttacaaaaga aacactaatc ccaataattt ttattccatg tatagtaatt ggattaaaat
    10801 aaactcacct agtaaccttt cggagtctag gttagcttgg tgttacggtg atcttggcat
    10861 tgcaaaagca ttaaattatg caggagtatc attgggtaat agcgatatta ctaatttttc
    10921 ttttgaagtt ttaaataaaa caataccgag gttcatgaat agccacgttg aagatgcatc
    10981 tttttgtcat ggttctagtg gaatttctca tatatataat catttttacc agataacagg
    11041 ttatgacgca tataaaaatt ctgcaatatt ttggctgaat gatactctta atagaattaa
    11101 atatttagag gttaactcct catttagtac cgaacttaat gatgtttgtt ctattctaac
    11161 aggattgtct ggtgttggtt tgtccttact atcttcaata gaagataagg aagataattg
    11221 gaatgaatta ttattattat tgtaatttaa atttatataa aatgaataaa tatattcctt
    11281 ataatcaatg cattattaga acaccgttat ttcctattaa ttacattgat aaaatagaag
    11341 actttgagtt atcaatattt cagcaatcat ttaaagaagc agtttatatt gcaactcctg
    11401 ttctctacca agaattatat ataaaaaata atataaatga aaggactata aattccgcta
    11461 taaaatatta tgtccgtagt tgtacaagat gtacaccata cggtattttt gcgggttgtg
    11521 atatagtacc tattagaatt gatgataatt attctaacat aattatgtca gaccttaaaa
    11581 attataagac atatacacgt atagatatga actatttatg tgaacttata agaaagttag
    11641 atttaatgcc acagatacag aatgcaatta catatcatgt aaatacaact tcgtattttt
    11701 taggtaaaaa tttgcgctat attgagtatc gcatcaataa atctaaacgg aattatacct
    11761 tctctgaaat ttctcataca ccatatttaa acaatataat aaaagcatta aagaagaccc
    11821 ctttaacaaa aaaggaaata attaggctat tgataaaaaa taaagaaata gaagaggaag
    11881 aagctttaaa ttttgttcag acacttattg atgaacaaat cttaattagt aatttggagc
    11941 catctgtggt tggcgaagat ttgattcaac aattgcatca taatctttca gaaattaatt
    12001 ataatctaga attcattaat tctctcatat atttattaaa agaatgtgac aaggaatcac
    12061 taggaaataa agaatcgatt attaataata tataccgttt attatcggat ggtatgttat
    12121 ttgagcaaga tactctaatg caagtagata ctttaaataa agttaaacaa ggcataatag
    12181 gaaataacat tactaaagtt attgataaat gcatatactt cttttcaaaa tttcagccaa
    12241 gccataaatc tgagactttt gagcttttta agaggagatt ttatgaaaag tatgaagagc
    12301 aggaagtacc actagttgta gcattagacc cacaagtagg aattggttat ggaaactgga
    12361 ctgagaacaa tggcgatata aatcctttat tacaagggtt gcccaatcct tttttagacc
    12421 gatcttataa gatcgatatg gatctgactc cagtcacgat gttgctaata aaaaagtatg
    12481 aagaggctat aaaacaagga ttgcatgaga ttgaaatact agatgaagat ttaaatgaat
    12541 tcgaagaacg tgacttaaaa cttcctcagt gttcagtcat gctctctgtt ttatcaaatg
    12601 atgatacgcc atctatttta ttaaaaggga taattggggg tgctacttct agattgattt
    12661 caagatttga atatttagat tctaaaattg aaaattttgt aaatgaaata aataaacgtg
    12721 atgaattata ttataaagat tgcatagtcg ctgaggtaat gcatcttcca gaggatagaa
    12781 ttggaaatat tcaaatgcat cctaataata gacaatatgg aatttgctat ttatctagtc
    12841 caaccactaa gtatgtaaag aagatcatac caattgatga tataaccatt tcagtgtacc
    12901 atggacaaga agttatattg aaatcaaaaa agaataagaa aagaattatt ccaatgttat
    12961 caactgcaca taatacaaaa aatgggcttc caatatatag ctttttatca gattatataa
    13021 atcaagaatc catgtcttac tcttttgatt ggggatcata ttttcataat aaatcatttc
    13081 tcccaagagt tatctattct aatgtaatac taaaaccagc tagatggtta attcatccca
    13141 atgaatttcc acaaaataaa aatttaaata gcgatgaatt gtattcttgg aaactaaaac
    13201 agagaatacc agacgaaata ttaataactt tgggggacaa tcaattatat ataaatttca
    13261 acaaagaaca tcttgttaaa atttttatta gtgagctcaa gaaaaagaga ccaattattt
    13321 tagaagaatt tctatatagt tctaaaaata taaatcttgt tgagtctcaa gaaggttttt
    13381 ttgctaatga acttataata aatctatata agaaatgaca cagcgtatat ttataatagg
    13441 aggagaatgg atatatttta aaatatattc tggaccgaaa acaatagaaa atatttttat
    13501 taatgatatt atgtgcaaga taaatcttct tataaaacag agaatgatag attcattctt
    13561 ctttgtaaga tatatggatc ctaattatca tattaggtta agattacatt gcactaatat
    13621 aaataattat gcatttattc ttcatcttat ttataaaact cttaaccgtt atgttaagga
    13681 tttaatcata actaaagttc aattagacac ttatacaaga gaattggaaa ggtatgaata
    13741 caatgagata gttcattttg agactttttt ttactacgac agctgtttga ttactaagtg
    13801 tcttaaaaga ctaaattgta cagaccaaga tagatataaa atatcgatga agtttattga
    13861 ttcgattatg gatatatgta attttagcct tgatgaaaaa attaatttta cagaaaagaa
    13921 tagtaaagca tattttttag aattatatca atctgattgt actattgggc atatattaaa
    13981 tttgaaatat agaaaatata gaaatgaaat tgagaaatgt ttgaatgatg agagtaaaca
    14041 ctgttggtgg aataaagaga taaaaaaaaa tatatatatt atgagaacta ttcctctaaa
    14101 catcttgacc ggtaaaaata ataaactttc tagcataatt cacatgcatg taaatcgtat
    14161 gtatagaatt aaccagagaa ctgtagaatt agtaatttat tcactatcaa ccgacaaaac
    14221 ctacattttg ccgaaccata tttatatatg cctgacaaac aacgtattat aatactgttt
    14281 gtcatttttg ttaaacctac cccctctcta aaacaacgac atttgtattc cggtaggact
    14341 tttgtttcgg cttttcaacc gcttagcata tgagcgccta ccctcagtga ctacccaagc
    14401 caattccaaa tggcttatca aatgtatccg tatcaaggct gcaattgttg agaacgcttt
    14461 agagctttt
//
