LOCUS       gnlProkkaCNNODJGE_103  13839 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CNNODJGE_103.
ACCESSION   gnlProkkaCNNODJGE_103
VERSION     gnlProkkaCNNODJGE_103
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 00:10:27
            Original ID  :: gnl|Prokka|CNNODJGE_103
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13839
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13839
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[917:3347]"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      918..3347
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
     cand_cluster    1..13839
                     /SMILES="NC([*])C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /kind="single"
                     /product="NRPS-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13839
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS-like"
                     /region_number="1"
                     /rules="cds((PP-binding or NAD_binding_4) and (AMP-binding
                     or A-OX))"
                     /tool="antismash"
     CDS             complement(20..913)
                     /locus_tag="ctg91_1"
                     /transl_table=11
                     /translation="MQTENFTLGKKELLILLGLILVLPFPINWALIELNPLTLMAGADD
                     VPTWIGFGGSYIGGIIGGVISIMILNKTLQQTGVLHHDLKLLQLDTIIYTQQQDWFTGF
                     KQELAENLKSIDLYVLNTVVSSISMKNYAYAKEVLTEINKGLEYQMVAASFSFTSTHLS
                     SEEKKYMSLVRRVQTEYSSFIKDILYYIPLAETISSRKKLNYDQLMDYTLSQYDYLQGQ
                     EGESTASGAIIPRVMEIDPSDDIRKELERIMEERLTGRTYLYHLKSDLAEATHQLIIYE
                     ENRINSILHKPEREMN"
     CDS             complement(918..3347)
                     /NRPS_PKS="Domain: AMP-binding (12-401). E-value: 1.8e-83.
                     Score: 272.2. Matches aSDomain:
                     nrpspksdomains_ctg91_2_AMP-binding.1"
                     /NRPS_PKS="Domain: PP-binding (509-568). E-value: 2.7e-10.
                     Score: 32.6. Matches aSDomain:
                     nrpspksdomains_ctg91_2_PP-binding.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: PP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     260.1; E-value: 5.3e-79)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg91_2"
                     /sec_met_domain="AMP-binding (E-value: 3.1e-88, bitscore:
                     285.4, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 4.8e-11, bitscore:
                     32.6, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTNIQENLSRSLSTWGDKPAVVAKDGTVSYQMLERYSANIAQSI
                     RQRLSVTDPSGLRNICIGVCMERNKTLVPAILAIFRLGATYLPIDPSLPDNRKRYMAEN
                     ADMVLLLTDSSNEVGGIPSVRQLYLNGEQLSEPVVGDYTEVLPDDCAYIIYTSGTTGNP
                     KGVRISYRNLDTFTRNLVDKKLYHLSDPANRYLAFASISFDASILELMMCIPVGGTLIL
                     AGEDERRDISLLDELIRREKVNIAFFPPSLLGMFADLDFPSFKTLLFGAEAIGEKLFNR
                     LKQQPYRLMNVYGPTENTVLSTIRIVGKDTSYDDIGYPLKGTVCYVLSENLQQTTLGAT
                     GELCLGGPQVSLGYIGSVQLNEKSFISYDGERLYRTGDLVQQQPDGSIRFIGRKDTQVK
                     IRGFRIELTEIAERLNRDPDVERAHVVVVERNGRQLLGAYLQPSVSGNFHPEEVKERLR
                     AELPYYMIPNLWQVVDHFQRTINDKIDVRALPAFTSLELKYVPPVHPGEVILCGILKEM
                     LGLPQVSVEADLIDDLGLTSLDMLRLVTEANKKGCPINVSAVYTARNLRRLLLVPRQEP
                     IYWYRQQNLKKPVIILVCGSAYFNHLYFNLADRLYPKYDFLVVDAIYDHFNKVATDIPE
                     LLEYYVRTVQPMIRERTVYALTGFCMGAELAVGLAEMLHRSMGIMPKVFALDGQAWQNP
                     ALCQNYPLLVFPGDTDEMVRERNEIINIYFRTTPNLIYQGEVIVLLSGLFHQQAGLSPE
                     ESWTEENYRIFRTEYDNCERLWNKYYPNAPVLRLPADHWHFLEGESLEQLITVFLK"
     aSDomain        complement(1644..1820)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg91_2_PP-binding.1"
                     /evalue="2.70E-10"
                     /label="ctg91_2_PP-binding.1"
                     /locus_tag="ctg91_2"
                     /protein_end="568"
                     /protein_start="509"
                     /score="32.6"
                     /tool="antismash"
                     /translation="LCGILKEMLGLPQVSVEADLIDDLGLTSLDMLRLVTEANKKGCPI
                     NVSAVYTARNLRRL"
     aSModule        complement(1644..3311)
                     /complete
                     /domains="nrpspksdomains_ctg91_2_AMP-binding.1"
                     /domains="nrpspksdomains_ctg91_2_PP-binding.1"
                     /locus_tags="ctg91_2"
                     /monomer_pairings="X -> X"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(2118..2180)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg91_2_0004"
                     /evalue="1.50E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg91_2"
                     /protein_end="410"
                     /protein_start="389"
                     /score="36.2"
                     /tool="antismash"
                     /translation="FIGRKDTQVKIRGFRIELTEI"
     aSDomain        complement(2145..3311)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg91_2_AMP-binding.1"
                     /evalue="1.80E-83"
                     /label="ctg91_2_AMP-binding.1"
                     /locus_tag="ctg91_2"
                     /protein_end="401"
                     /protein_start="12"
                     /score="272.2"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="LSTWGDKPAVVAKDGTVSYQMLERYSANIAQSIRQRLSVTDPSGL
                     RNICIGVCMERNKTLVPAILAIFRLGATYLPIDPSLPDNRKRYMAENADMVLLLTDSSN
                     EVGGIPSVRQLYLNGEQLSEPVVGDYTEVLPDDCAYIIYTSGTTGNPKGVRISYRNLDT
                     FTRNLVDKKLYHLSDPANRYLAFASISFDASILELMMCIPVGGTLILAGEDERRDISLL
                     DELIRREKVNIAFFPPSLLGMFADLDFPSFKTLLFGAEAIGEKLFNRLKQQPYRLMNVY
                     GPTENTVLSTIRIVGKDTSYDDIGYPLKGTVCYVLSENLQQTTLGATGELCLGGPQVSL
                     GYIGSVQLNEKSFISYDGERLYRTGDLVQQQPDGSIRFIGRKDTQVKIR"
     CDS_motif       complement(2253..2339)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg91_2_0003"
                     /evalue="1.20E-08"
                     /label="NRPS-A_a6"
                     /locus_tag="ctg91_2"
                     /protein_end="365"
                     /protein_start="336"
                     /score="27.3"
                     /tool="antismash"
                     /translation="LGATGELCLGGPQVSLGYIGSVQLNEKSF"
     CDS_motif       complement(2841..2897)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg91_2_0002"
                     /evalue="1.50E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg91_2"
                     /protein_end="169"
                     /protein_start="150"
                     /score="26.8"
                     /tool="antismash"
                     /translation="AYIIYTSGTTGNPKGVRIS"
     CDS_motif       complement(3078..3119)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg91_2_0001"
                     /evalue="3.50E-03"
                     /label="NRPS-A_a2"
                     /locus_tag="ctg91_2"
                     /protein_end="90"
                     /protein_start="76"
                     /score="11.0"
                     /tool="antismash"
                     /translation="LAIFRLGATYLPID"
     CDS             complement(3360..5726)
                     /gene_functions="transport (smcogs)
                     SMCOG1082:TonB-dependent siderophore receptor family
                     (Score: 167; E-value: 1.6e-50)"
                     /gene_kind="transport"
                     /locus_tag="ctg91_3"
                     /transl_table=11
                     /translation="MKRCLLYILCCFGVVQLSAQPADNIRNSFVKAETFYKSGDIDEAC
                     RILEENLSSFQGTMHTEACRLAALCCLALDRFPEAEKYVSLLLKDEPYYYISLQDPERF
                     ADMVRKHRETKVTLVTASQQVETPEEAPVPVTLITEEMIRAIHARCLRDVLIAYVPGIS
                     GLSSNEEMNLAMRGVYSPEQENILIMQDGQRLNSYITNAVSPDYGISLAKVKQIEVLRG
                     PASSLYGSVALTAVINIVTKDGVDVRNGSISVSAGNRGQLAADLLLGKHDMNMDFMAWF
                     SLYRATGESVFVPAEKQYALYPRDGFIRLDNYSGFPAMDGGIKLQRGNLLFSFSMNYAK
                     KRQPYSMWLFSSPYSYERFRTFDGSGPGYSRWSAREQAVYSRTWQRITFSTAFYTDWNK
                     NVHYETSGDTLQDYPIFPNYDYQPIIYPTRGAFQYIRWMDFNVGFNGRVNYAYDWGKLG
                     KGNMLGGVEWNRYTLYDSEYLEGMNFKEIVRTWIEKRLYTGHEMNTDAFFQIKHNLHKN
                     WIVNAGIRYDYKRRSNKRTLQAFSPRLSLIYLRNGLNIKASYSRAFVDAPYYYRNNEMD
                     TYSGGENLQAEYLSSYQVTCAYHHSPSHIDVECNLFYNRASHFLFTQPETRVYENAGSL
                     DMGGVEVVARYKADRLSLDGNLCFQKVLNYTNFFVTDGSVNNVPGFSMNLVANYFLLKK
                     KVQSWSAHLKLNCSSHCYTQVSVLEDGLNGDATNYTVRLPGYAVFSFTTRYKYKRIEGS
                     LGIENLFNNRYECGGATVPIRQKGRWISASILYNF"
     CDS             complement(5723..6559)
                     /gene_functions="regulatory (smcogs) SMCOG1003:sensor
                     histidine kinase (Score: 136.3; E-value: 3e-41)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg91_4"
                     /transl_table=11
                     /translation="MEKNISQEKRIEELEARLKEQEKLGSLGLLSAGIAHEIQNPLNFV
                     INFSKLSGQLLADLADRVDEAKARIPEAELEDIKDILSGLRENVDKIKEHGDRAISIIR
                     GILLYSRGKEDEFMPTQIQKLTKEYVWLAYHAMRANYKNFNIAIREDYAKDIPSIRLIP
                     QDFSRAVLNVMNNACYAVWKKWQNAPEGYSPEIMVTLEKLDKRIVLSIRDNGEGMGPEV
                     KRKLFDSFFTTKPVGQGTGLGMAIVRDIIENKHHGKVLFDSVLHEYTCFRFIIPIA"
     CDS             complement(6582..9419)
                     /locus_tag="ctg91_5"
                     /transl_table=11
                     /translation="MKKIVFLIMCLCSVYANSQEGIPFFVNYPASVYQAHNRNFDVVCD
                     SCGNVYFANFEGILHYDYSRWETIYTPGFSRVTRLFRDSEGRIWVGGYNVFGRIERDGR
                     GCITLRTLLSDLDTDSLGELEDMAEIDKRIYLKATSGRYYTVQSDSILAPVHVLPAQLQ
                     EKWRNQSSVSMNRAFSLPGGETISINSAHGLIMDDSGKKERFSVTERNGLCSNAVSGIA
                     ADGRGNLWGATDNGVFHVFIPSLFSRYTSGEGLKGEVISAVSYKGMIYTGTLQGLYVLK
                     QNTFVPVQGISQACWQLCLSPQGELYAASGDGVYVIRDYNHSEKLTDMAAYSLAFIGHT
                     NLLMGTMDGIYQYSADEERIKKISDVEKVVRLEVKKDRSVWAKTLYGEIYLREEGESSF
                     VLQDRESEEVMTEYTDNDGCHWQTNLKGKEVQVHHSQIDTEKFNQCLYAIRNYVVRVIY
                     IEEDRAAWFGGDFGLIRMDLEKARTFTPVAPRIYLREVCLNRDSVYWGGDLPEESGGAD
                     WQINSTVPRLGNDVRSIRFSFATDAPCFTGSNEYRYRLVGYDPEWSSWDSGTVKEYANL
                     SSGTYTFCVRARDIYGTESEMKQFRFSLLPPFYLQWYCLILYAVAFGMLLFVLFKWRMR
                     SLLKEKERLEVLVGQRTKQLVQQKNEIEEKSLKLEKALKELGQAQDELVRQEKMATVGK
                     LTQGLIDRILNPLNYINNFSHLTSGLLKDLYQNLESVKELLDEDTYLDSVDVINMMRDN
                     LEKIEEHGSNTTRVLKAMEEILRDRNRQLEKTELIGLCRKDMELLSSYYQKEITAMHIA
                     VRTSLPDNPLFIDGNAEQLGKTIMSLLNNGMYAIAKKYGKKAYPAEIGLALESKDGQVV
                     IRLYDNGVGIEQSILDKIFDPFFTTKTTGEAAGIGLYLSKEIILNHHGQIAVRSEKDEL
                     TEFTITLPLWEEKSV"
     CDS             complement(9416..11017)
                     /locus_tag="ctg91_6"
                     /transl_table=11
                     /translation="MIKLNENIIRWIIAVPCILLTVCLVLYRAYRHSASDRERLALSLE
                     EFRDKEKKSVLIQRVSQQMEEIAYQQKDISEKRRQEAVAQTQKANRMQQQAELARERAL
                     AAQLEAEKAYRMADEQKNLAMERQLQAEQSKRVADTLAFLALGRSLGTLSVTQYRSGNM
                     ELASLLAYTAWWFTKRYDGDVYHPAVFNALSLSCRQDQLWFGHKGAVTGIKLLSGGEEK
                     ARAGRNPLPGLVTVGKYGEMIRWKSENGQTYTSELLLNDPCYDFRDVLLRSDSQMYALS
                     YCGQLISTDSAGIVTRFLPKGEYRQLISIASNLVLAVSTTGIYSFDCVNHEIQPYFQPE
                     HSITCVGQMEGYLYVFFKNGTVALLSSDGTFLRFIDSLPENSVVTAFCPLANERYAIGC
                     REGVILICDKNGNIRQKLIGHQAAVTAISRKGNKLFSSSYDCTLRLWDLRKGKTESAVI
                     VTSPGWIHTFCFHPDGTSVFMGDEQGRLYRVPVSPDHMAAVVRQGLQRDFTREEWEYYI
                     GKQIPFESYYLKTYQP"
     CDS             complement(11014..11442)
                     /locus_tag="ctg91_7"
                     /transl_table=11
                     /translation="MTLLQFCPVDGRLDEILSMLMHSREVASHPSLSYAIRLVSEEIIV
                     NILNYAYPQQAEGYLTLCLWDEDGEITLEFIDGGIPFNPLDKADPDISLPLEQREIGGL
                     GIFLVREMMDDVAYTYVNKENRLTIKKKYLQPTDEPVS"
     CDS             complement(11457..11762)
                     /locus_tag="ctg91_8"
                     /transl_table=11
                     /translation="MEKYEIHSVGSVLDSNTSGDEQAKIVALIGQGHSVALDLSGCSYV
                     SSAGLRVMLYAFKLAKAKSKDVCLVGVSQEVKDVMHMTGFDKFFRFYQTLDELSQP"
     CDS             complement(11781..12950)
                     /gene_functions="other (smcogs) SMCOG1054:hypothetical
                     protein (Score: 219.1; E-value: 2.2e-66)"
                     /gene_kind="other"
                     /locus_tag="ctg91_9"
                     /transl_table=11
                     /translation="MAVKILSVDDELDLEVLLTQYFRRQIRKGEYEFAFAHNGLEALQK
                     LLETPDFDIILSDINMPEMDGLTLLAKVNELKNPAMKCIMVSAYGDMDNIRSAMNKGAF
                     DFATKPIDLDDLSRTIEKAIEQVRYIRESQQEHNQLESIKNDLAIAGEIQQTILPRSFP
                     PFPELTEVVDIYASMTPAKDVGGDFYDFFQIDDERIGLVIADVSGKGVPASLFMAVSRT
                     LLRATALRGVSSAECLTYANKLLCKESLDSMFVTVFYGIYHYKTGMMDYTNAGHNPPYL
                     LRGGRTVECLPVASNFVVGVFDDIEFESNTLTFGIGDTLLLYTDGVTEAFNDKREQFSE
                     SNLQDILASMHESSSAKEVVTSVLQSVKTFSGDYPQSDDITLLSLQRIK"
     CDS             13298..13837
                     /locus_tag="ctg91_10"
                     /transl_table=11
                     /translation="MLIILKQDDSCQVAQTTCTTNSLEIRYKDYSVLKKTLDLNTKSIN
                     SDSCIELIIYGTHGNEKEICKLTKPDIKDLTYFFKGKVCRLVLDACHSACHIPHFKEML
                     TDDGIILCHVGICQVNSIETKTGKDTYERWINGNKEGLKVWSDGIVPAIYTQKNNTLTY
                     YECSKFEVDINHPFTET"
ORIGIN
        1 catattatat taatatatgt caattcattt ctctctcagg tttatgcaga atagagttta
       61 tacggttctc ttcataaata attaattgat gcgtagcctc tgcaagatct gacttcaggt
      121 gatacaaata ggtacgcccg gttaatcttt cttccattat ccgttctagt tctttccgta
      181 tatcatcaga tggatcgatt tccataacac gcggtatgat ggctcccgaa gctgtagact
      241 ccccttcctg accttgcaaa taatcatatt gggacaaagt atagtccatc agctgatcat
      301 agtttagttt tttcctggaa gatatcgttt ctgccaaagg aatatagtaa agaatatcct
      361 tgataaaaga gctatattca gtctgtacgc ggcgtaccag actcatatac tttttttctt
      421 cggatgataa atgcgtagaa gtgaaagaaa aggatgcggc aaccatctga tattcgagcc
      481 ctttattgat ttctgtcaac acctctttgg catatgcata gtttttcatg gatatagacg
      541 aaacaaccgt attcaacaca tacaaatcaa tagatttgag gttctctgcc agttcttgtt
      601 tgaaaccggt aaaccaatct tgttgctgag tataaattat ggtatctaac tgcaggagtt
      661 tcaaatcgtg atgaagtaca cctgtctgct gaagtgtctt gttcagaatc ataatcgaga
      721 tgacccctcc gatgattcct ccaatataac tgccgccgaa accaatccag gtgggcacat
      781 cgtctgcacc cgccatcaga gtcaacggat tcagttcgat taatgcccaa ttgattggaa
      841 aaggcagtac aagaatcaag ccaagcaaaa taagaagctc tttcttacct aaagtgaagt
      901 tttcagtctg cataaatcta cttcaaaaac acagttatta attgttccaa tgattcccct
      961 tctaaaaagt gccaatgatc tgccggcaat cgcaaaacag gagcgttcgg ataatattta
     1021 ttccataatc tttcgcaatt gtcatattct gtccggaata tacgatagtt ttcctccgtc
     1081 cacgactctt caggagacaa tcccgcctgt tgatggaaca atccggacag caaaacaata
     1141 acctctccct gataaatcag attaggagtg gttcgaaaat aaatatttat gatttcgttc
     1201 cgttcacgta ccatttcatc tgtatctccg ggaaatacca acaaaggata attttgacag
     1261 agagccggat tttgccaagc ctgtccatcc agagcaaaaa cttttggcat tatccccatg
     1321 gagcgatgta acatttcggc caggccgaca gccagttcag ctcccataca aaagccggta
     1381 agcgcataga cggtacgctc ccggatcatt ggctgaaccg tccggacata atattccaac
     1441 agttccggaa tatccgtggc cactttatta aaatgatcgt agatagcatc tacaactaga
     1501 aagtcatatt tgggataaag gcggtcggcc aaattaaagt acaaatgatt aaaataggca
     1561 gatccacaaa ccagaatgat tacgggtttc ttcaggtttt gctgcctgta ccaatagata
     1621 ggttcttgcc gcggaacgag caataatcgg cgcagattac gggcagtata aactgcagat
     1681 acgttgatgg gacatccttt tttattggcc tcggtaacaa gcctcaacat atccagcgaa
     1741 gttaatccca gatcatcaat caaatcggcc tcaacactga cttgaggcaa acctaacatt
     1801 tccttcaaaa ttccacataa gataacctcc cccggatgaa caggaggaac atacttcaac
     1861 tccaacgaag taaaagccgg gagcgcccgg acatcaattt tatcatttat agtacgctga
     1921 aaatgatcta ccacctgcca taaattgggt atcatgtagt aaggaagttc tgcacgcaaa
     1981 cgctctttga cctcttccgg atgaaagtta ccggagactg agggttgcaa ataggctccc
     2041 aataattgac gcccattccg ctcaacaact actacgtggg ctctctccac gtccggatct
     2101 ctattcaatc gttctgctat ttcagtcaat tcgatacgaa agccacgtat tttgacctga
     2161 gtatcttttc gcccgataaa ccgtattgaa ccgtccggtt gctgctgtac caagtcacct
     2221 gtcctgtaca accgttctcc atcgtacgag atgaatgatt tttcattcag ctgaacactc
     2281 ccaatatatc ccagcgaaac ctgaggtcct cccaagcaaa gttctcctgt agccccaaga
     2341 gttgtctgtt ggaggttttc agacaaaaca taacagacag ttcccttgag cggatagcca
     2401 atatcgtcat acgacgtatc tttgcctaca atccgtatgg tactgagtac ggtattctct
     2461 gtcggtccat atacattcat caaccggtaa ggctgctgtt tcagcctgtt aaataacttt
     2521 tcaccaatag cctccgcacc aaagagcaga gtcttaaagg atggaaagtc aaggtcggca
     2581 aacatgccca gcaacgaagg agggaaaaaa gcaatattca ccttctcgcg cctgatcagt
     2641 tcgtctagta aagaaatatc tctgcgttcg tcctcaccgg ccaggatcaa tgttcctccg
     2701 accggaatac acatcatcag ttctaatatg gaagcatcaa aactgatact cgcaaacgcc
     2761 agatacctgt ttgccggatc agacaaatga tacaatttct tatctaccag attcctcgta
     2821 aatgtatcca gattccgata actaatacgt acacctttgg gattgcctgt tgttccggaa
     2881 gtatatataa tataggcgca atcatcggga agaacttcag tatagtcacc aacaaccggt
     2941 tcggatagtt gctccccatt caggtaaagt tggcggacgg acggaattcc acctacttca
     3001 ttcgatgaat cggtcaacaa caaaaccata tccgcatttt cagccatata ccgtttacga
     3061 ttatccggca gcgagggatc tatcggtaaa taagttgccc ctaaccggaa aatagccaga
     3121 atggcaggta ctaaagtttt gtttcgttcc atacaaactc cgatacagat attccgaagt
     3181 ccggacggat cagttaccga taaacgttga cggatagatt gtgctatatt ggcagagtaa
     3241 cgttccagca tttgataaga gacggtaccg tcttttgcaa cgaccgccgg tttgtcaccc
     3301 caggtagaga gtgatcgaga aagattttct tgaatgtttg ttttcattat tagtttgatt
     3361 tagaaattat acaatatact ggcggaaatc caccttcctt tctggcggat aggaacagtc
     3421 gctcctccgc attcatatcg gttattgaaa agattctcaa tgcccagact gccttctatc
     3481 cttttatact tatatctggt agtgaaagaa aagacagcat aaccgggcaa acggactgtg
     3541 taattcgtcg catctccatt gagtccatct tccaatacac ttacctgagt gtagcagtgg
     3601 ctactgcaat tcaattttaa atgggcagac cagctctgta ctttcttttt aagtaaaaag
     3661 tagtttgcta caagattcat agaaaagccg ggtacgttat tcacagatcc atcggtaaca
     3721 aaaaaattgg tataattcaa tactttctga aaacacaggt ttccatccag gctcagtcgg
     3781 tctgccttat aacgagcaac aacctcgaca cctcccatat ccagagaacc ggcattttca
     3841 taaacacgtg tttccggctg tgtgaacagg aaatgggacg cccgattata aaataaatta
     3901 cactctacat ctatatgtga aggtgaatga tgataagcac aagttacctg atatgaactt
     3961 agatattcag cttgcagatt ttcgccaccc gaataggtat ccatttcatt gtttctgtaa
     4021 taatagggcg catcgacaaa tgctctggaa taactggctt tgatatttaa tccgttcctg
     4081 agataaatta gtgacagacg gggagaaaaa gcctgtaatg tccgcttatt acttcgccgt
     4141 ttatagtcat acctgatgcc ggcattgaca atccaatttt tatgcaggtt gtgtttaatc
     4201 tggaaaaagg catccgtgtt catctcgtgt cccgtgtaaa gtcgtttttc gatccacgtc
     4261 ctgacgatct ctttaaaatt cataccttcc aaatactcgg aatcataaag cgtataccga
     4321 ttccattcca caccgccaag catattgcct ttccccagct tcccccaatc ataggcatag
     4381 tttacacgcc cattaaagcc tacgttaaaa tccatccagc ggatgtattg aaatgctccg
     4441 cgagtcggat aaataatagg ttgataatca tagttaggaa aaataggata gtcttgtaaa
     4501 gtatctcccg aggtttcata atgtacgttt ttattccaat cggtataaaa tgcggtactg
     4561 aaagtgatcc gctgccacgt gcggctataa acagcctgtt ctcttgccga ccacctggaa
     4621 tatcccgggc cggaaccgtc aaaagtacga aaccgctcat aagaatatgg agaagaaaag
     4681 agccacatgc tataaggttg ccttttcttc gcgtaattca tactgaaact aaaaagcaaa
     4741 tttccacgtt gcaatttaat tcctccatcc atggcaggaa atcccgaata attgtccaga
     4801 cggatgaatc cgtccctggg gtaaagagca tattgttttt cggccgggac aaaaaccgat
     4861 tctcccgttg cacggtacaa ggagaaccat gccataaagt ccatgttcat gtcgtgcttt
     4921 cccaatagca ggtcagcagc caactggccc cgattaccgg cgctgacaga tatggaacca
     4981 ttacgaacat ccaccccgtc tttagtaact atattaatca cggctgtcaa agccacactg
     5041 ccataaagcg aagaagccgg tccgcgcagc acctctattt gtttgacttt tgccagacta
     5101 ataccataat ccggcgaaac agcattagta atataactgt tcagacgttg tccatcctgc
     5161 ataatcaata tgttctcctg ttcgggagaa tataccccgc gcatagccag attcatctct
     5221 tcattggaag acaaaccgga tataccgggc acataagcta tcagtacatc ccgcaggcac
     5281 cgggcatgga tagcccgtat catctcctcc gtaattaaag taacaggcac cggagcttct
     5341 tccggggtct ctacctgttg tgaggctgtg accagagtta ctttagtctc cctgtgtttc
     5401 cttaccatat ccgcaaagcg ttccggatct tgaagcgaga tataataata aggttcgtct
     5461 ttcaataaca gcgaaacata cttttccgct tccgggaagc ggtctaaagc taaacagcat
     5521 aatgcagcca aacggcacgc ctcggtatgc atcgtacctt gaaaagacga cagattctcc
     5581 tccaagatac gacaagcttc atcgatatct ccgctcttat aaaatgtttc cgcctttaca
     5641 aacgaattac ggatgttatc cgccggctga gctgacagtt gcacaacccc aaagcagcaa
     5701 aggatatata gcagacagcg tttcatgcga taggaatgat aaaccggaaa caagtatatt
     5761 catgcaggac cgaatcaaac aatacttttc catggtgttt gttttctata atatcacgaa
     5821 cgattgccat accaaggcct gtcccctgcc ccaccggttt tgttgtgaaa aaagagtcaa
     5881 atagttttcg tttgacctcc ggacccatgc cctctccgtt atcacgaata gaaagtacaa
     5941 ttcttttatc caacttttct aaggtcacca ttatctcggg ggaatatcct tcgggagcat
     6001 tctgccattt tttccatact gcatagcagg cattattcat cacattcaag actgcccgac
     6061 tgaaatcctg cgggatcagc cggatcgagg ggatatcttt agcataatct tcacggatag
     6121 caatattgaa attcttataa ttggcccgca tggcatgata agccagccac acatattctt
     6181 tagtcaattt ttgtatttgt gtaggcatga attcgtcttc tttccccctg gagtaaagca
     6241 aaataccacg gataatgctg atagcccgat caccatgctc tttgattttg tccacattct
     6301 ctctcagccc ggaaagtata tctttgatat cttccagttc cgcttccgga atacgagctt
     6361 ttgcttcatc caccctatcg gccaggtcgg ccaacaattg accggacagt ttactgaaat
     6421 tgatgacaaa attcaaagga ttctgtatct cgtgtgcaat gcctgcactc aacaagccca
     6481 atgatcccag cttttcctgc tctttgagcc gtgcttccaa ctcttcaatt cgtttctctt
     6541 gtgaaatgtt tttttccata atcaatctgt tctatgttta tttatactga cttttcctcc
     6601 cacaatggca gagtgatagt gaattctgtc aattcatctt tttcagaacg tactgctatc
     6661 tgcccatggt gatttaatat gatttcctta ctcagataca aaccgatacc tgctgcctct
     6721 ccggttgttt tggtagtaaa gaacggatcg aagattttat ccagaatact ctgctcgatc
     6781 cccactccat tgtcatatag gcgaatgact acctgtccgt ccttactttc caatgccagg
     6841 ccaatctctg ccggataggc tttcttaccg tattttttgg ctatggcata catgccattg
     6901 ttaagaagac tcataatggt ttttcccagt tgttcggcat tcccgtcaat aaacaacgga
     6961 ttatcgggca aggaagtacg aaccgcaatg tgcatagccg taatctcctt ctgataataa
     7021 ctgctcaata gctccatgtc tttccggcat aaaccgatta attctgtttt ttccagttgc
     7081 ctgttacggt ctctcaggat ttcttccatg gccttcagta cacgagtggt gttacttcca
     7141 tgttcctcaa tcttttccag attatctctc atcatgttga tgacatccac cgaatccaag
     7201 taggtatctt catccaaaag ttcttttaca ctctccagat tctgatatag gtccttcagt
     7261 aatcctgagg tcaggtggga aaaattatta atgtaattca acggattcag aatacggtca
     7321 atcaaccctt gagtcagttt gcctacagta gccatttttt cttgtcgaac caattcatct
     7381 tgtgcctggc ccagctcctt caatgctttt tccaatttta aggacttttc ctcaatttca
     7441 tttttttgtt gtaccaactg tttggtacgt tggccgacaa ggacctctaa cctctccttc
     7501 tctttcagca aactgcgcat tctccattta aacaatacga acaacagcat cccaaaagca
     7561 acggcatata gaatcagaca ataccattgc aaataaaaag gaggcaataa cgaaaagcgg
     7621 aattgtttca tttcactctc tgtgccgtaa atatcacggg cccggacaca aaacgtatac
     7681 gtacccgacg aaaggttggc atactctttc acagtcccgg aatcccacga actccattcc
     7741 ggatcataac cgaccaggcg atatctatac tcattggaac cggtgaaaca gggcgcatcg
     7801 gtagcaaatg aaaaacgaat ggaacgtaca tcattcccca aacgaggtac tgtactattt
     7861 atctgccagt ccgctccccc ggactcttcc ggcaaatctc ctccccaata gacagaatca
     7921 cggttcagac aaacttcacg aagatagatg cggggagcaa ccggagtaaa tgtccgggcc
     7981 ttttcaaggt ccatccgaat taaaccaaaa tcaccgccga accatgccgc cctgtcttct
     8041 tcaatataaa tcaccctcac gacataattc cgaatggcat acaggcattg gttgaatttc
     8101 tccgtatcaa tttgcgaatg atgtacctgt acctcttttc ctttcagatt tgtctgccaa
     8161 tgacagccat cgttgtccgt atactcggtc attacttctt cactctctct gtcttgaagt
     8221 acaaaagagc tttcgccctc ttcccgcaaa tagatttctc cgtacaacgt tttagcccat
     8281 acagaacgat ctttcttcac ttccagacga acgacttttt cgacatcgga aattttcttt
     8341 atccgttcct catctgccga atattgataa atcccatcca tagtgcccat cagaaggttc
     8401 gtatgcccaa tgaatgccaa tgaataagct gccatatctg tgagtttttc cgaatgatta
     8461 taatcccgga tcacatacac accatcgccg gacgctgcat ataattctcc ttgtggagaa
     8521 agacacagtt gccaacatgc ttgcgaaatt ccctgaacag gaacaaaagt gttttgcttc
     8581 aatacgtata atccctgtaa ggtcccggta tatatcattc ctttgtaaga gacagccgat
     8641 attacctctc ccttcagacc ttcaccagag gtataacggc tgaacaaaga gggaataaaa
     8701 acatgaaaca caccgttatc cgtagctccc cagagattgc cacgcccatc ggccgcaata
     8761 cccgaaacag cgttactgca taagccattt ctctcagtta cggaaaaccg ttcttttttc
     8821 ccactgtcat ccattattaa tccatgggca gagtttatcg agattgtttc tcctccgggt
     8881 agagaaaacg cccgattcat tgagactgag gattgatttc tccacttttc ctgcaattga
     8941 gccggaagta cgtgaaccgg tgccaaaatg gaatctgact gaaccgtata atatcttcct
     9001 gatgtagctt tcagataaat gcgtttatct atttctgcca tatcttccaa ttcgcccaaa
     9061 gagtctgtgt ccagatcgga aagaagggtt ctcaacgtaa tacatccgcg tccatcacgc
     9121 tctatccgtc cgaacacgtt atatcctccc acccatatcc taccttccga atcacgaaac
     9181 aaacgggtga cacgggaaaa gcccggtgta taaatagttt cccaacggct atagtcataa
     9241 tgaaggatac cttcgaaatt agcaaaatag acatttccac aactgtcgca aacgacatcg
     9301 aaattacgat tgtgcgcctg ataaaccgaa gccggatagt ttacaaaaaa cgggatacct
     9361 tcttgtgaat ttgcatatac cgagcaaaga cacattatca aaaagactat ctttttcatg
     9421 gctgatacgt ttttaggtaa taggattcaa atggaatttg cttaccgata taatactccc
     9481 attcttctcg agtaaaatca cgctgtaacc cctgacggac aacagcagcc atgtgatcgg
     9541 gtgaaacagg cacccgatac aaccgcccct gttcgtctcc cataaagaca gatgtaccgt
     9601 ccggatgaaa gcaaaaagta tgaatccaac cggggcttgt cacaataacg gccgactcgg
     9661 tctttccttt acgaagatcc cacagacgca gtgtacaatc gtaactactc gaaaacagtt
     9721 tgttcccttt ccgggaaata gcagtaaccg cagcctgatg ccctatcaac ttctgccgga
     9781 tatttccatt cttatcacaa atcaggataa ctccttcacg acagccaatg gcatatcttt
     9841 cattggcaag aggacagaat gcagtaacca cactattctc gggcaagctg tctataaatc
     9901 tgagaaatgt accatccgac gaaagtaaag ctactgtccc attcttaaaa aaaacataga
     9961 gatagccttc catttgaccg acacaagtta tcgaatgttc cggctgaaaa taaggttgta
    10021 tctcatggtt gacacagtca aaagaataaa tacctgttgt ggaaaccgcc aataccaagt
    10081 tagaggcaat cgaaatcaat tgccgatatt ctcctttagg caaaaagcgg gtaacgatac
    10141 cggcggaatc cgtggagata agctgcccgc agtatgacaa ggcatacatc tgtgaatcgg
    10201 accgcaacag cacatcccga aaatcataac agggatcatt caacagtaat tcggaggtat
    10261 aggtctgccc attttccgat ttccaacgta tcatctcacc gtacttgccg acagtgacca
    10321 atcccggcag aggattccga ccggctcttg ctttttcctc gcctccggat aacagtttga
    10381 tcccggtaac agctccttta tgcccgaacc aaagctgatc ttgcctgcaa gacaaagaca
    10441 atgcattgaa aacagccgga tgatatacat cgccatcata tcgcttggta aaccaccagg
    10501 cggtatatgc caacagagaa gctaattcca tgttgcccga ccgatactga gtaacagaga
    10561 gtgtccccaa tgaacgtccc aaagccagaa aagccaatgt atcggcaacc ctcttcgact
    10621 gttcggcctg tagttgccgt tccatcgcca gattcttttg ttcatctgcc atccgatacg
    10681 ctttctcagc ctccaattgt gcagcaagcg ctctttcccg tgccaactct gcctgctgtt
    10741 gcattcggtt ggccttttga gtttgcgcaa cggcttcctg tcttctcttt tcggaaatat
    10801 ccttttgttg ataagcaatc tcctccattt gttgactgac ccgttgtata agaaccgatt
    10861 tcttttcttt atcccggaat tcctccagag acagagcaag acgctccctg tccgatgccg
    10921 aatgacgata tgcccggtat aggaccagac atactgtcaa aagtatacaa ggaacggcaa
    10981 tgatccaacg gatgatattt tcgtttaact tgatcatgat acaggttcat cagtgggttg
    11041 cagatatttc tttttaatgg tcaaccgatt ctccttattc acgtacgtat acgctacgtc
    11101 atccatcatt tcacgtacca ggaaaatgcc caatcctcct atttcacgct gttctaacgg
    11161 taatgaaata tcaggatcgg ctttatccaa aggattgaat ggaataccac catctataaa
    11221 ctccaaagta atctctccgt cttcatccca taagcacaga gtcagataac cttctgcctg
    11281 ctgcggataa gcgtaattga gaatattgac aatgatctcc tcactgacca aacggatggc
    11341 ataagacagg gaaggatgtg aagcaacttc acgactatgc atcagcatac taagaatttc
    11401 atctaacctc ccatcgacag ggcaaaactg aagtaacgtc attgctcagg taatttttag
    11461 ggttgtgata attcatcgag agtctgataa aaacgaaaga atttatcgaa tccggtcatg
    11521 tgcatcacgt ctttaacctc ttgtgacaca ccgacaaggc aaacatcctt acttttagct
    11581 ttcgccagct taaaagcata aagcatgact ctcaatccgg cactggatac ataagaacag
    11641 ccgctgagat ctaatgcaac agaatgtcct tgcccgataa gagctacaat ttttgcttgt
    11701 tcgtcaccgc ttgtatttga atccaagacg gaacctacag aatgaatttc atacttttcc
    11761 atcgttcttt tattttaata ttatttgatt cgttgaagag aaagcaaggt tatgtcatcg
    11821 gactgaggat agtctccgga gaaagtctta acagactgca atacactcgt aacaacctct
    11881 tttgcggaac tactttcgtg catagacgcc aatatatcct gtaagttact ttccgagaat
    11941 tgttcccgtt tgtcgttaaa agcctctgtg acaccatccg tatacagaag taaagtgtca
    12001 ccgatgccga acgtcaatgt attactctca aattcaatat catcgaatac gcctaccaca
    12061 aaattagaag cgacaggcaa gcattcaaca gtccgtccgc cgcgaaggag ataaggagga
    12121 ttatgcccgg cattggtata gtccatcatg ccggttttat aatgataaat cccataaaag
    12181 accgtaacaa acatagagtc caggctctct ttacacagta acttattggc ataagtaagg
    12241 cattctgccg atgaaacacc ccgaagagca gttgcacgga gcagggttcg actaactgcc
    12301 atgaacaagg atgccggcac ccctttcccg gatacgtcag caatcaccag cccgatacgt
    12361 tcatcgtcaa tctggaagaa atcataaaaa tcgccaccta catcttttgc cggagtcatg
    12421 gaagcataaa tatcaaccac ttccgtcagt tccggaaaag gaggaaagga acggggaaga
    12481 atcgtttgct ggatttctcc cgcaatggcc aggtcatttt tgatagattc cagttggttg
    12541 tgctcctgct gtgactcacg gatatagcga acctgttcga tcgccttttc aatagtccgc
    12601 gacagatcat ccaaatcgat cggtttggtt gcaaaatcaa acgctccctt gttcatagca
    12661 gaacgtatgt tatccatgtc tccataagca gagaccatta tacacttcat tgccggattt
    12721 ttcagttcat tgaccttagc caatagggtc aacccatcca tctccggcat attaatatca
    12781 ctcaggatga tatcgaaatc gggagtttcc agaagtttct gtaaagcttc caacccgtta
    12841 tgggcaaaag cgaactcgta ttcacctttt cgtatttgtc gcctgaagta ctgggtaagt
    12901 aatacttcta aatcaagttc atcatctaca ctcaatattt ttactgccat atctattgtt
    12961 atttatgaat ttcaaccgtt tgttctgacg tttatgatgg caaaaataga gagtgaccgc
    13021 cccggttaca attttatatt ttaaacagga agaatgtttt tccgaatgga cgatattgtc
    13081 ttataagcat acaggtatat tgctttcgtg gcttagaaga cagcacctga aagattgatt
    13141 tacactcctg aaagaaacta ttccgtattc agaatttata tttttaagat ggaacttttc
    13201 ttctcacttt tgtcaccgta agcttacaaa gaataaatag aaacggcgga ttccgaaaag
    13261 ccgaagaaag agtaggaact ttttacgaat cactattatg cttattattt taaaacaaga
    13321 tgatagttgt caagttgcac aaacgacatg tacaacaaac tctttagaaa tccgatacaa
    13381 agattatagt gtactgaaaa aaactctgga tttgaacaca aaatctatta atagcgatag
    13441 ctgtatagag ttaattattt acggaacaca cggaaatgaa aaggaaattt gcaaactaac
    13501 caaaccagac ataaaagatc tgacctattt cttcaaagga aaagtttgta gattagttct
    13561 tgatgcttgc catagcgcct gccatattcc acatttcaaa gagatgttaa cagatgatgg
    13621 aatcatatta tgtcatgtag gtatctgcca agtaaacagc atcgaaacta aaacaggtaa
    13681 agacacctat gaacggtgga taaatggcaa taaggaagga ttaaaagtat ggtcggatgg
    13741 aatcgttcca gctatctata ctcaaaagaa taacacttta acttactacg aatgtagcaa
    13801 attcgaagta gatattaatc acccttttac cgaaactga
//
