LOCUS       c00060_gnlPro..        15514 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GPFKCPEM_67.
ACCESSION   c00060_gnlPro..
VERSION     c00060_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-03 17:32:33
            Original ID  :: gnl|Prokka|GPFKCPEM_67
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15514
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15514
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[413:5514]"
                     /cutoff="2000"
                     /detection_rule="(Complex1_51K and minimum(5, [FMN_bind,
                     FeS, Fer4, Fer4_9, NQR2_RnfD_RnfE, Rnf-Nqr, RnfC_N,
                     SLBB]))"
                     /neighbourhood="10000"
                     /product="Rnf_complex"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      414..5514
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="2000"
                     /detection_rule="(Complex1_51K and minimum(5, [FMN_bind,
                     FeS, Fer4, Fer4_9, NQR2_RnfD_RnfE, Rnf-Nqr, RnfC_N,
                     SLBB]))"
                     /neighbourhood="10000"
                     /product="Rnf_complex"
                     /protocluster_number="1"
     cand_cluster    1..15514
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Complex1_51K and minimum(5, [FMN_bind,
                     FeS, Fer4, Fer4_9, NQR2_RnfD_RnfE, Rnf-Nqr, RnfC_N,
                     SLBB]))"
                     /kind="single"
                     /product="Rnf_complex"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15514
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Rnf_complex"
                     /region_number="1"
                     /rules="(Complex1_51K and minimum(5, [FMN_bind, FeS, Fer4,
                     Fer4_9, NQR2_RnfD_RnfE, Rnf-Nqr, RnfC_N, SLBB]))"
                     /tool="gutsmash"
     CDS             complement(3..209)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Epimerase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg60_1"
                     /sec_met_domain="Epimerase (E-value: 3.7e-13, bitscore:
                     42.6, seeds: 96, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKERILVTGGTGYIGSHTVVELQNSGYEVIIIDNLSNSNADVVDN
                     IEKVSGIRPVFEKLDCLDFDGLDA"
     CDS             complement(414..986)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: Rnf-Nqr"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg60_2"
                     /sec_met_domain="Rnf-Nqr (E-value: 3.8e-63, bitscore:
                     205.7, seeds: 650, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEYILIFISAIFVNNIVLSQFLGICPFLGVSKKVDTALGMSAAVA
                     FVLTIATIVTFLIQKFVLDAFGLQYLQTITFILVIAALVQMVEIILKKVSPALYQALGV
                     FLPLITTNCCILGVAILVIQKDYDLLTGVVYAFSTAIGFGLALVLFAGLREQMSLVKIP
                     EGMKGTPIALITAGLLAMAFMGFSGVV"
     CDS             complement(1000..1587)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: Rnf-Nqr"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg60_3"
                     /sec_met_domain="Rnf-Nqr (E-value: 6.6e-70, bitscore:
                     227.7, seeds: 650, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNFKVLMNGIVKENPTFVLLLGMCPTLGTTSSAINGMGMGLATM
                     FVLICSNVVISLIKNLIPDMVRIPSFIVVIASFVTLLQMVMQAYVPGLYATLGLFIPLI
                     VVNCIVLGRAEAFAAKNNALSSMFDGIGMGLGFTIALTLLGAVREFLGTGRVFNLSIIP
                     EEYGMLVFVLAPGAFIALGYLIALINSLKKAN"
     CDS             complement(1605..2273)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: FMN_bind"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg60_4"
                     /sec_met_domain="FMN_bind (E-value: 1.8e-23, bitscore:
                     76.1, seeds: 891, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKLESSLKNMLLVLTGVTAISVALLAYVNELTKGPIAEANAKTL
                     NEALKEVLPEFTNNPVAECDTVFSEKDGKKIVDFIIYPAKNGDQWVGTAVEAKSMGFGG
                     ELKVLVGFDAEGKIYNYSLLSHAETPGLGSKAADWFKEGNKGSIKGMNPGEQPLTVSKD
                     GGQVDAITASTITSRAFLNAVNAAYGAYKGDGGANGTTGASQKAVQKSETAIVDSVVIK
                     "
     CDS             complement(2270..3262)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: NQR2_RnfD_RnfE"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg60_5"
                     /sec_met_domain="NQR2_RnfD_RnfE (E-value: 7.8e-119,
                     bitscore: 389.4, seeds: 472, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENKLIVSLSPHVHGGDSVQKNMYGVLIALIPAFIVSLVYFGLGA
                     LIVTATSVIACLFFEWAIGKFLLKKETTTICDGSAVITGVLLAFNLPSNLPVWIIILGA
                     LFAIGVGKMSFGGLGNNPFNPALAGRVFLLLSFPVQMTSWPVVGQLTAYTDATTAATPL
                     ALMKQAIHGDVSAFGQLPDAWSLFIGNNGGCLGEVSAAALILGLLYMLWKRIITWHIPV
                     SILVTVFVFSGIMHLANPEAYVSPVIQLLSGGLMLGAIFMATDYVTSPMSKKGMLIYGV
                     CIGLLTVVIRLFGAYPEGMSFAILIMNAFTPLINTYCKPKRFGEVAKKK"
     CDS             complement(3268..4605)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: SLBB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: RnfC_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: Complex1_51K"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg60_6"
                     /sec_met_domain="Fer4_7 (E-value: 1.1e-08, bitscore: 28.7,
                     seeds: 208, tool: rule-based-clusters)"
                     /sec_met_domain="SLBB (E-value: 9.4e-16, bitscore: 50.6,
                     seeds: 67, tool: rule-based-clusters)"
                     /sec_met_domain="Complex1_51K (E-value: 2.3e-50, bitscore:
                     163.6, seeds: 88, tool: rule-based-clusters)"
                     /sec_met_domain="RnfC_N (E-value: 3.9e-30, bitscore: 97.0,
                     seeds: 53, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 2.7e-05, bitscore: 17.7,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLKTFSIGGVHPHENKLSAHQPIVTAEVPAKAVILLGQHIGAPAK
                     PIVVKGDVVKVGTKIAEANGFVSAAIHSSVSGKVAKIDSIVDASGYAKPAIFIDVDGDE
                     WEESIDRSPELVKECELTSEEIVKKIADAGIVGLGGACFPTQVKLCPPPSFKAECVIIN
                     AVECEPYLTADHQLMLEHAEEVMVGVAILMKAVKVNKAFIGIENNKPDAIQLMTKVASS
                     YAGIEVVPLKVKYPQGGEKQLIDAITKRQVASGALPISTGAVVQNVGTAFAVYQAVQKN
                     KPLFERVITVTGKSVAQPSNFLARIGTPMQQLIDACGGLPEDTGKIIGGGPMMGKALVN
                     TDVPTAKGSSGILIMNRKEAKRGEVQNCIRCAKCVSACPMGLEPYLLSALAENTEFERM
                     ESERIMDCIECGSCQFTCPANRPLLDYCRLGKGKVGAMIRARQAKK"
     CDS             complement(4642..5514)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: Fer4"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: FeS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_17"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1016:4Fe-4S dicluster domain (Score: 36.6; E-value:
                     1.8e-11)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg60_7"
                     /sec_met_domain="Fer4_7 (E-value: 1e-11, bitscore: 38.4,
                     seeds: 208, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 2.9e-08, bitscore: 26.5,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_2 (E-value: 1.5e-08, bitscore: 27.5,
                     seeds: 214, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_6 (E-value: 7e-08, bitscore: 25.5,
                     seeds: 134, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_17 (E-value: 2.8e-08, bitscore: 27.4,
                     seeds: 82, tool: rule-based-clusters)"
                     /sec_met_domain="FeS (E-value: 3e-10, bitscore: 32.8,
                     seeds: 364, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 8.5e-06, bitscore: 19.3,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNLILIAVISLGAIALVLAAVLYVASKKFAVYEDPRIAQVSEVLP
                     QANCGGCGYPGCSGFADACVKAGSLEGKFCPVGGQPVMSQVASILGLDAGTAEPMVAVV
                     RCNGTCTNRPRTNMYDGAKSCAIAASLYGGETGCSYGCLGCGDCVAACQFDAIHMNPET
                     GLPEVDEEKCTACGACVKACPKAIIELRAKGKKSRRVYVSCVNKDKGAVARKACTVSCI
                     GCGKCVKTCPFEAITLENNLAYIDYNKCKSCRKCVEVCPQHTIIELNFPPRKPKEETPV
                     AEAAKTAEA"
     CDS             5695..5889
                     /locus_tag="ctg60_8"
                     /transl_table=11
                     /translation="MRKARRTACMPMEVAPIIVTSSPIFHADEVSVTSITFSLLSAEEQ
                     CPLTLQVEQADVWMILTKT"
     CDS             complement(6190..6594)
                     /locus_tag="ctg60_9"
                     /transl_table=11
                     /translation="MIKQDYLIRMIQEIISLIVNAILNKKKFRKDEWTEYDCLTRQILG
                     VSQEELLSMSLDEMIDCYEGDPNRMGKIELAAVTLLKVSDEVESDILQKSKLRQDGLSL
                     LKYVQKESSTFSIQRTNLIRMIEINESLKM"
     CDS             complement(6723..8156)
                     /locus_tag="ctg60_10"
                     /transl_table=11
                     /translation="MKTSHISTLAFAILFSSSVMAQKTNKPVSETVQSEVKADTLSETL
                     QQYLVLKLNLDGPKPKIDTVSILYNKYIGELEYLNDPSVPMRYIKTDPDYYRLFVPLTY
                     YNSPIAEYSTMHWKFKEPFVTPSLSSQLLPPYDTLQFSKAERASRLVNVALMDLYLNHP
                     NLVVNTEDHIMSRKLYHGDKKIEVPKTEVKSLFRADKVEDNVGEAEMVISKPNWWVTGG
                     NGSLQITQNYISDNWYKGGESNNAVMANLQLFANYNDREKVQFENLFEAKLGFNSSPSD
                     EYHKYLVNTDQLRLYSKLGIQAANNWYYTITGEFKTQFVKGYKANSEELVAAFLAPADV
                     IVSVGMDYKLKKKKFNLSVFMSPLTYNLRYIGNKNVDETKFGLDKGKCSKNDFGAQVQP
                     TISWTIIPSIVVDSRLNYLTNYKWVRVEWENTFNFVLNRYLSTKLFVHARFDDSAKPTT
                     GSSYFQLKELLSFGLNYKW"
     CDS             8540..10141
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg60_11"
                     /sec_met_domain="GATase (E-value: 8.6e-55, bitscore: 178.5,
                     seeds: 97, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VGETKYIFVTGGVASSLGKGIISSSIGKLLQARGYKVTIQKFDPY
                     INIDPGTLNPYEHGECYVTVDGHEADLDLGHYERFLGIQTTKANNITTGRIYKSVIDKE
                     RRGDYLGKTIQVIPHITDEIKRNVKLLGNKYKFDFVITEIGGTVGDIESLPYLESIRQL
                     KWELGQNALCVHLTYVPFLSAAQELKTKPTQHSVKELQSLGVQPDILVLRTEHDLNTNL
                     RKKVALFCNVAENAVVQSIDASTIYEVPLLMQEQGLDETILQKMGLPVGERPPLGPWKD
                     FLNRRANATETVTIAMVGKYVELQDAYKSILESLSQAATYNDRKVKIEYVSSEHLTPDN
                     VDEQLGHVNGVVICPGFGSRGIEGKFVAAKYTREHNIPTFGICLGMQCMAIEFARNVLG
                     YADANSIEMDEKTKHNVIDIMEEQKAITNMGGTMRLGAYECVLKKDSKVYEAYKEEHIQ
                     ERHRHRYEFNNDYRKQFEEAGMKCVGINPESDLVEIVEIPTLKWYIGTQFHPEYSSTVL
                     HPHPLFVSFIKAAIDK"
     CDS             10190..12046
                     /locus_tag="ctg60_12"
                     /transl_table=11
                     /translation="MDKNTITGLVLIGILLVGFSFLSRPSKEQIAAQKRYYDSIAVVQQ
                     QEEALRAKTEAALANEKEETAADSASLFFNATKGKEAFTTIQNNLVEITLDNKGGRVYS
                     ALLKNYMGQDKKPVVLFNGSDASMNFNFYNKKGALQTKDFYFEAVNKTDSSVTMRLAAD
                     SASYIDFIYTLKPDNYLMSFVIKATGMDGKLAASTNYVDISWSQRARQIEKGYTYENRL
                     ADLTYKYTGDDVDNLSASKDDEKSVSERLDWIAFKNQFFSSVFIAEQDFEKTTVKSKME
                     KQGSGYIKDYSAEMSTFFDPTGKQPTDMYFYFGPNHYKTLTALDKGREEKWELNNLVYL
                     GWPLIRWINKWITINVFDWLSGWGLSMGIVLLLLTIMVKIVVFPATWKTYMSSAKMRVL
                     KPKIDEINKKYPKQEDAMKKQQEVMGLYSQYGVSPMGGCLPMLLQFPILMALFMFVPSA
                     IELRQQSFLWADDLSTYDAFITFPFHIPFLGNHLSLFCLLMTVTNILNTKYTMQQQDTG
                     AQPQMAAMKWMMYLMPIMFLFVLNDYPSGLNYYYFISTLISVVTMIILRRTTDENKLLT
                     ELEAKKKDPKQMKKTGFAARLEAMQKQQEQLAKERANKQNKK"
     CDS             12135..13466
                     /locus_tag="ctg60_13"
                     /transl_table=11
                     /translation="MTTKYTYKEIWIIAYPILISLIMEQLIGMTDTAFLGRVGEVELGA
                     SAIAGVYYLAIFMMAFGFSIGAQILIARRNGEQQYQAIGPIFYQGVYFLLSLAVVAFTL
                     SLCFSPHILKKVISSEHIYDASISYINWRVFGFFFSFVGVMFRAFFVGTTQTKTLTLNS
                     VVMVLSNVVFNYILIFGKFGAPQLGIAGAAIGSSLAEMVSVIFFVIYTWRRIDCKKYAL
                     NHLPGFRPEMLKRILNVSFWTMIQNFFSLSTWFMFFLFVEHLGERALAITNIIRNVSGI
                     PFMVTMAFAATCGSLVSNLIGAGEIKCVPGTIRQHIRIGYIFVLPLVILFALFPNLILS
                     IYTDIPDLREASIPSLWVLCSAYLILVPANVYFQAVSGTGNTRTALGLELCVLAIYLIY
                     ITYMILYLRVDVAVCWTTEHLYGICILFLSYLYIKKGNWQKKQI"
ORIGIN
        1 acggcatcta aaccgtcaaa atccaagcaa tccagtttct cgaaaacagg acgaatacct
       61 gatacctttt cgatattatc tacgacatca gcatttgaat tagataaatt atcaatgatg
      121 attacttcgt atccactgtt ttgcagctct accacagtat gagagccgat atatccggtt
      181 ccgcctgtta ctaaaattct ttctttcata atgtgtataa tggttagttt tttcggttta
      241 cttgtaaagt gtttgcaaat gtaacaaaat taatttagat aaatgcacaa aaaacgaata
      301 ttatttcata acgcaaacag ggattaagac aaaataacag aaaaagcggc ggaagaacta
      361 ccccaccggt agcctatccg ccgctccatc cttcagttgt ttgtcgtcag gatttataca
      421 actccggaga atcccataaa tgccatagcc agcaatccgg ctgtaattaa agcaatcgga
      481 gtacctttca ttccttcggg aattttcaca agactcatct gctcacggag tccggcgaaa
      541 agtaccaggg ccagaccgaa accaatagca gtagagaatg catatacaac acccgtcagt
      601 aggtcataat ctttttggat aacaagaatt gccacaccca agatacaaca attcgttgta
      661 atcaagggaa ggaatacgcc caatgcctga taaagtgcgg gagaaacttt cttcagaata
      721 atttctacca tctgcaccaa tgcagcgata accaagataa acgtgatagt ctgcaagtac
      781 tgcaacccga aggcatcgag tacaaacttc tggatcagga acgttacgat cgtagcaatg
      841 gtaagcacga aagctaccgc tgcactcata cccaatgcag tatccacctt cttggaaaca
      901 cccaagaaag gacagattcc cagaaattgc gacaacacaa tgttattaac aaagattgcc
      961 gagataaata tcaatatata ttccataatc gtttatattt taattcgctt tcttaaggct
     1021 gttaatcaac gcaatcagat atcccaatgc gataaacgca cccggagcaa gcacaaagac
     1081 aagcataccg tattcttccg gaatgattga caagttgaat accctgcctg tacccaggaa
     1141 ctcacgaaca gctcccagca atgtaagggc aattgtaaag cccaatccca taccgattcc
     1201 gtcgaacata gaagaaagtg cattattctt ggctgcaaat gcttctgcac gtcccaacac
     1261 aatgcagttc acaacaatca atggaataaa aagtcccaat gtagcgtaca gtccgggtac
     1321 atatgcttgc attaccatct gaagcaaagt cacaaaagat gcaatgacta caatgaatga
     1381 cggaatacgc accatgtccg gaatcaggtt ctttatcaat gaaatcacta cattggaaca
     1441 gatcaataca aacatagtgg caagccccat gcccatacca ttaatggccg aggaagtcgt
     1501 accgagtgta ggacacatac caagcaggag cacaaatgtc ggattctctt taacaatccc
     1561 attcattaat actttaaagt tattcatatc tttatactcc tttcttattt aatgactact
     1621 gaatcgacaa tcgcagtttc ggacttctgc acagctttct gcgaagcacc ggtcgtacca
     1681 ttagcaccgc catcgccttt ataagcacca taggcagcat tcacagcatt caaaaatgca
     1741 cgtgaagtga tagtagaagc agtaatggca tctacctgtc cgccgtcttt acttacagtc
     1801 agcggttgct cacccggatt cattccctta atgctgcctt tgtttccttc tttgaaccag
     1861 tcggccgcct tggaaccaag tcccggagtt tcggcatgtg acaacaaaga atagttgtag
     1921 attttacctt cagcatcaaa accaacaagt actttcaatt ctccgccaaa tcccatcgac
     1981 ttggcttcta ctgctgttcc tacccattga tctccgtttt tagccggata aatgataaag
     2041 tcaacaatct tcttgccatc tttctcacta aacacggtat cacactctgc gaccggatta
     2101 tttgtaaatt cgggcaaaac ttcttttaaa gcttcattca atgtcttcgc attcgcctct
     2161 gcaatgggac ctttagtcaa ctcattcaca taagccagca aagctaccga aatagctgtt
     2221 actccggtga gtaccagcaa catatttttc aatgatgatt ctaacttttt catttcttct
     2281 tcgctacctc cccaaagcgt tttggtttgc aatacgtatt gattagcgga gtgaatgcat
     2341 tcataatcag aatagcaaac gacatacctt ccggatatgc accaaacaga cggataacaa
     2401 ccgtcagcaa accgatgcag acaccataaa tcaacatacc ttttttactc atcggagagg
     2461 tgacatagtc tgttgccata aagatagcac ccagcatcag acctcccgaa agcaactgga
     2521 tcaccggaga aacataagct tcgggatttg ccagatgcat gataccggaa aatacaaata
     2581 cagtaaccag aatggataca gggatatgcc atgtaatgat tctcttccat aacatataaa
     2641 gaagacccaa aatcagggca gcagcactca cttcacccag acatccacca ttgttaccaa
     2701 taaacagact ccaagcatcg ggcagttgac caaaagccga gacatcccca tgaatagcct
     2761 gtttcatcaa tgccaaagga gtggcggcag tagtagcatc ggtataagca gtcaactgac
     2821 cgaccaccgg ccaggaagtc atctgtaccg ggaatgacaa taacagaaac acacgccctg
     2881 ccagtgccgg gttaaacgga ttgttcccca agccgccaaa tgacatctta ccgacaccaa
     2941 tagcaaacaa agcacctaaa ataataatcc atacaggtaa gttagacggt agattgaacg
     3001 ccagcaacac tcccgtgatg acagcagaac cgtcacaaat agtagtggtt tctttcttca
     3061 gcaagaactt accgattgcc cattcaaaaa acaaacaggc tatcacagaa gtagctgtga
     3121 caatcagtgc acccagtccg aaatatacga gcgaaacgat aaaggcagga atcagcgcaa
     3181 tcagcacacc gtacatattc ttttgtacgc tgtctccacc atgaacgtga ggcgataatg
     3241 atacaattaa tttattttcc atacttatta ttttttagct tgacgtgcac gaatcatagc
     3301 tcctactttc cccttaccca gacgacagta gtcgagtaac ggacgattgg caggacaagt
     3361 gaactggcaa gagccacact cgatacaatc catgattctt tctgattcca ttctttcaaa
     3421 ttctgtgttc tcagccaaag cggaaagcag atacggctcc agtcccatcg ggcaggcact
     3481 cacacacttt gcacaacgaa tgcagttctg tacttctccg cgttttgcct ctttccggtt
     3541 cataatcaaa attccggaac ttcctttagc agtgggcaca tcagtattaa ccaatgcttt
     3601 acccatcatc ggaccaccgc caattatttt tccggtatcc tccggcaaac cgccacaggc
     3661 atcgatcaac tgctgcatcg gagtaccaat acgcgccaaa aagttagaag gctgggcaac
     3721 agacttaccg gtcaccgtaa tgacacgctc aaacaaaggc ttatttttct gtacagcttg
     3781 atatacggca aatgcagtac ctacattctg cacaactgct cctgtagaga taggtaatgc
     3841 gccgcttgca acctggcgct tcgtaatagc atcgattaac tgcttctcac ccccttgagg
     3901 atacttcact ttcaaaggaa caacttcaat accggcataa ctggatgcga ctttcgtcat
     3961 cagttggata gcatcgggtt tattgttttc gatacctata aaagccttat tgactttcac
     4021 cgccttcatc agaatagcca cccctaccat tacctcctcg gcatgctcca acatcagttg
     4081 atggtcggct gtcaagtaag gttcacactc tacagcgttg ataatcacgc attctgcttt
     4141 aaatgaagga ggcggacaaa gtttgacttg agttgggaaa caagctcctc ccaaaccaac
     4201 aatgcctgca tctgctatct tcttcacaat ctcttccgaa gtcaattcgc actcttttac
     4261 caattcagga ctacgatcga tagactcttc ccattcatcc ccgtctacat caataaaaat
     4321 agcaggttta gcataaccgc tcgcatcgac aatagagtca atcttagcga ctttaccact
     4381 gacagaagag tgaatggctg ccgaaacaaa gccattagct tcggctattt tagtgcccac
     4441 cttcaccaca tcacctttta ccacaatagg cttagcaggc gcaccgatat gctgccccag
     4501 cagtatcaca gcttttgccg gaacctctgc cgtaacaata ggttgatgtg ctgagagttt
     4561 attttcgtgt ggatgaacac caccaattga aaatgtcttc aacatacaat tctgtatttt
     4621 atctgtttat tactcgtttt tttaagcttc ggcagttttg gcagcttcgg caacaggcgt
     4681 ttcctcttta ggtttacgag gagggaaatt caactcgatg atagtgtgct gcggacaaac
     4741 ttcaacgcac ttgcgacaag acttacattt attgtaatcg atgtaagcga gattgttttc
     4801 aagtgtaatt gcctcgaacg gacaagtttt gacacactta ccacaaccga tgcaacttac
     4861 cgtacaggct ttgcgtgcga cagccccttt gtctttgttg acacaagata catatacacg
     4921 acgcgatttc ttacctttgg cacgaagctc gattatcgct ttcggacagg cttttacaca
     4981 agctccgcaa gccgtacact tttcttcatc cacctcagga agtcctgttt ccggattcat
     5041 gtgaatagca tcgaactggc aggcagccac acagtcgcca catcccaaac atccatagct
     5101 acagccggtc tctccgccat aaagcgaagc agcaatagca cagctctttg caccgtcata
     5161 catatttgta cgcggacggt tcgtgcaggt tccgttacat ctaaccactg caaccatcgg
     5221 ttctgcagtt ccggcgtcca atccgagaat agaggcaacc tgagacatca caggctgtcc
     5281 acccaccgga caaaacttac cttccagcga accggctttg acgcaagcat cggcaaatcc
     5341 gctgcaaccc ggataaccac atccaccgca gttagcctga ggcaacactt cggatacctg
     5401 ggcaattcgt gggtcttcgt acacggcaaa tttcttagaa gcaacataca atactgcagc
     5461 caatacaagc gcaatagctc ccaaagaaat cactgcaatc agaatcaaat tcataatttt
     5521 tagttattta ttggttttat agtaaaagaa aatttttgtt tcaaccgagt tctgttcaac
     5581 catattatat aataataagg aataagcacc gccaaagcag caaatgcccc atatagttca
     5641 ctatgaagaa ctgtcttgaa aatgaaaagg ccaaagatta aaagaaagag aggaatgaga
     5701 aaagccagaa gaaccgcttg catgcccatg gaggtggcac caataatcgt cacctcgtcc
     5761 cctatcttcc atgcagacga agtatcggta acttcaatta ccttctcctt gctatctgcc
     5821 gaagagcaat gtcccttgac actgcaagtc gagcaagccg atgtctggat gatcctcaca
     5881 aaaacctgag aaccacttat gttttccaca ataccttgat gagttattat attagtcatt
     5941 ttgcaaactg cacattacaa attgcggcaa atttaagcat aagtttgaaa attacgaagt
     6001 atttgaatgt tttttatagt gtaatatgaa gtctttttaa agtaattttt gctctatcaa
     6061 tcgggtatgg atacagaaaa agcaggcttt tcacctgctt tactaagaaa atgttatcat
     6121 cttctgatat ttttaaagaa attagaaaca aaaaccaatt cttttatcac tttctgttta
     6181 tttccccttc tacattttaa gagattcatt aatctcaatc atccgaatca aattcgtccg
     6241 ctgaattgaa aaggtactgc tttctttctg aacatatttt agcaaggaaa gcccatcctg
     6301 acgtaatttg gacttttgca aaatatcaga ttccacctcg tccgaaactt tcaacaaagt
     6361 cacggccgcc aattctatct tccccattct attaggatct ccttcataac agtcaatcat
     6421 ttcatccagg ctcatactta acaattcctc ttgagaaact cctaaaatct gtctcgtcag
     6481 gcaatcatat tcagtccatt catccttacg gaacttcttt ttattcaata tcgcatttac
     6541 aattaacgaa atgatttcct gaatcatccg tatcagatag tcttgtttaa tcataatatc
     6601 ctctttttga attagaactt acttaccacg gggagaatta acctcaccgg aaagaagaga
     6661 gccgactgaa gattccagtc ggcccctatt tcatatattt acattatgtc aattattccc
     6721 gattaccatt tataattcag accaaaactt agcaactcct tcagctggaa ataactgctg
     6781 ccagtagtcg gcttcgcact gtcgtcaaag cgtgcatgta caaatagttt ggtagaaaga
     6841 taacggttca atacgaagtt gaaagtattc tcccactcta cacgcaccca tttatagttc
     6901 gtcagatagt tcaaacggga atcgactaca atagacggaa taatagtcca tgaaatagta
     6961 ggttgaacct gtgcaccgaa gtcattcttc gagcatttgc ctttatccaa tccaaacttg
     7021 gtttcgtcca cgtttttgtt acctatataa cgaaggttat aagtcaacgg agacatgaat
     7081 acagaaagat tgaatttttt ctttttcaac ttatagtcca taccgacact gactatcaca
     7141 tctgcaggag caaggaaagc agctaccaac tcttcactgt tagccttata tccctttacg
     7201 aactgggttt taaactctcc tgtaatagta tagtaccaat tattggcagc ctgaatacct
     7261 aatttagaat acaaacgcaa ctggtcggta ttaaccaggt atttatgata ttcgtctgac
     7321 ggagaagaat tgaatcctaa tttagcttcg aacagatttt caaactgtac tttctcacgg
     7381 tcattgtaat tagcaaacaa ctgcagattg gccattacgg cattattgct ctcacctccc
     7441 ttgtaccagt tgtccgaaat atagttctgg gtaatctgaa gcgaaccgtt acctcctgtc
     7501 acccaccaat tgggcttgga gatcaccatt tccgcttcac ccacattgtc ttccacctta
     7561 tccgcacgga acaggctttt cacttctgtt ttcgggactt caatcttctt atcgccatga
     7621 tacaacttac ggctcatgat atgatcttcg gtattaacga ctaaattagg atggttcaga
     7681 tatagatcca tcaaagcaac attcaccagc cgggaagctc tctcagcttt agaaaactgc
     7741 aatgtgtcat acggcggcaa taattgcgaa gaaagagagg gagtaacaaa aggttcctta
     7801 aacttccagt gcatggtaga atattccgcg atgggagagt tataataagt cagcggtaca
     7861 aacagtcggt agtaatccgg atctgtctta atataacgca tgggtacaga aggatcatta
     7921 agatattcca actctcctat atacttatta tataagatgg acaccgtatc tatcttaggc
     7981 ttcggaccat ccagattcag tttcaggaca aggtactgtt gaagcgtctc ggaaagtgta
     8041 tctgctttca cttcactctg cactgtttca gaaaccggtt tgttcgtctt ctgcgccatc
     8101 actgacgaag aaaacaggat cgcaaatgct aatgttgaga tgtgactagt cttcattttt
     8161 ataacaaatt tggggcaaat ttacattaaa tagtttagat tacataaaat ttgctcgatt
     8221 ttaataggaa taacctatca aatgaatcta tacaacaatt cagctgtttt attggaacgt
     8281 gtgttatctc tcagaataat acagatcgaa ctgagaaccg ccttcccccg gctcgatagt
     8341 gcaagttgaa taaaggcgtg cttatatgcc ggcaaacatg tgactgtttg tcgttcaaac
     8401 atttcggtac ccggaattgc attttttaat aaatttgttt tgtagaaagc atccgttctt
     8461 ccccattttt ttgtaatttt gcggttttta agattcaaat caaaggattt agaaacaaat
     8521 tattaaaaca gttatagctg tgggagaaac aaagtatatt ttcgtcaccg gtggtgttgc
     8581 ctcttcttta ggaaaaggta tcatttcatc ttccatcggt aaattgctgc aagcaagagg
     8641 ttataaagta actatccaga agtttgaccc gtacatcaac attgacccgg gaacattgaa
     8701 cccttatgaa cacggagaat gctacgtgac tgtagacggc catgaagccg atcttgactt
     8761 aggacactac gaacgtttcc tgggcatcca gacaacgaag gccaacaaca tcacgacagg
     8821 ccgtatctat aagagcgtca tcgataaaga acgccgtgga gattatttgg ggaaaaccat
     8881 tcaggtgatt cctcatatca ccgatgaaat caaacgtaac gtcaagttac tgggtaacaa
     8941 gtataagttc gactttgtaa tcacagaaat tggcggaaca gtaggtgata tcgaatcttt
     9001 gccttatctg gaaagtattc gtcagttgaa atgggaactg ggtcagaatg ccttgtgtgt
     9061 acacctgact tatgtacctt tcctgtccgc cgcccaagag ttaaaaacca aaccgactca
     9121 acattccgta aaagagttgc aatcactcgg tgtacagccg gatatcctgg tgctacgtac
     9181 cgaacatgac ctgaatacca acttgcgcaa gaaggtcgct ctgttctgta atgtagccga
     9241 aaacgcagtt gttcagtcaa tcgacgcttc aactatttat gaagtacctc tgttgatgca
     9301 agagcaaggc ctggacgaaa ccatactcca aaagatgggt ctgcctgtag gcgaacgtcc
     9361 gccgttgggt ccttggaaag acttcctgaa ccgtcgtgcc aatgcaactg aaacagtaac
     9421 cattgcaatg gtaggtaaat atgttgaatt gcaggatgcc tacaaatcta ttctggaatc
     9481 cttgtcacaa gctgctacct acaatgaccg caaagtaaaa atagaatatg tatcatccga
     9541 acatctgact ccggacaatg tagacgaaca attgggacat gtaaacggag tagttatctg
     9601 tccgggattc ggttcacgcg gtatcgaagg taagttcgta gctgccaaat acacccgcga
     9661 acacaacatt ccgacattcg gtatctgtct gggtatgcaa tgtatggcta tcgagtttgc
     9721 ccgtaatgtg ttgggttatg ccgatgccaa ctccattgaa atggatgaaa agaccaagca
     9781 caacgtgatc gacatcatgg aagagcagaa agccatcacc aatatgggag gtactatgcg
     9841 tctgggagct tacgaatgtg tattgaagaa agactctaag gtatacgaag cctacaaaga
     9901 agaacacatt caggagcgtc atcgccaccg ctacgaattc aacaacgact atcgcaaaca
     9961 attcgaagag gccggcatga agtgtgtagg tatcaacccc gagtccgact tggtagaaat
    10021 tgtagagatt cctacattga aatggtacat cggaacacag ttccatccgg aatacagcag
    10081 taccgtacta cacccgcatc cgttgttcgt gtcgttcatc aaggctgcaa tcgataagta
    10141 aagatcgtta tcgtatagat tattaatcat taatcactta aaaaagagaa tggataaaaa
    10201 caccatcaca ggcctcgttt taataggtat attactggta ggattcagtt ttctgagccg
    10261 tcccagcaag gagcaaatag ccgctcaaaa gcggtattat gactctatag ccgtggtaca
    10321 gcagcaagaa gaagcactga gagccaaaac cgaagctgcg ctggctaacg aaaaagaaga
    10381 aacagcagcc gactcagcat cgctcttctt caatgccacc aaaggtaaag aggcgtttac
    10441 tactatccag aataatttgg tagaaatcac tctggataac aaaggcggcc gtgtttactc
    10501 tgccctgttg aaaaactaca tgggacagga taagaaaccg gttgtgttgt tcaacggcag
    10561 cgatgcttcc atgaacttca acttctataa caagaagggg gccctccaga caaaagactt
    10621 ctattttgaa gcagtcaata aaacagatag cagtgtaacg atgcgtctag ctgccgacag
    10681 tgccagctat atcgatttca tttatacact gaaacctgat aactacttga tgagctttgt
    10741 gatcaaagct acgggaatgg acggaaaatt ggctgccagc acaaactatg tggacatctc
    10801 atggtcacaa cgtgcccgcc agatcgaaaa gggatatact tacgaaaacc gtttggcaga
    10861 cctcacctac aaatacaccg gtgatgatgt ggataacctt tcggcaagta aagacgacga
    10921 aaagtccgtt tcggaacgtc tggactggat cgctttcaag aatcagttct tctcttccgt
    10981 attcatcgca gaacaggatt tcgaaaagac tacggttaaa tcgaaaatgg agaaacaggg
    11041 aagcggttac ataaaggact attccgccga gatgagtacg ttctttgatc cgaccggcaa
    11101 acaacctacc gatatgtatt tctacttcgg cccgaaccac tacaaaacgt tgactgcgtt
    11161 ggataaggga cgtgaagaga aatgggaact taacaacctg gtatatctgg gctggccgct
    11221 gattcgttgg attaacaaat ggatcaccat caacgtattc gactggttat ccggctgggg
    11281 attaagtatg ggtatcgttc tgttgttact caccatcatg gtgaaaatag tcgttttccc
    11341 ggcaacatgg aagacctata tgtcatcagc caaaatgcgg gtgctgaaac cgaaaatcga
    11401 tgagatcaac aagaaatacc ccaaacagga agatgcgatg aagaaacagc aggaggtgat
    11461 gggattgtac agccagtacg gtgtaagccc gatgggtggc tgtctgccga tgttgttgca
    11521 attccctatc ctgatggcat tgttcatgtt cgtaccgagt gctatcgaac ttcgtcagca
    11581 gagtttcctt tgggcggatg acttgtcgac ttatgacgca ttcatcactt tcccgttcca
    11641 tattccattc ttgggtaatc acctcagttt gttctgcttg ctgatgactg ttaccaacat
    11701 cctgaatacg aagtacacaa tgcaacagca ggatacgggt gcccagccgc aaatggctgc
    11761 gatgaagtgg atgatgtacc tgatgccgat catgttcctc ttcgtcttga acgactatcc
    11821 ttcaggattg aactattact acttcatttc gactctgatc agtgtagtaa ccatgatcat
    11881 attgcgccgg acaactgacg aaaacaaatt gcttaccgaa ctggaagcta agaagaaaga
    11941 tccgaaacag atgaagaaga ccggatttgc cgcacgcctg gaagctatgc aaaaacaaca
    12001 ggaacaattg gcaaaagaac gggctaataa gcagaataag aaataagaga tagaaatcag
    12061 cttaaatacc gaagagccgg acaagcagtg tatgtttgtc cggctttctt ttcctttatt
    12121 gaacagatta caacatgact actaaataca catacaaaga aatatggatt atcgcctacc
    12181 ccatcctgat cagcctgatc atggaacagc tgataggcat gaccgacact gcttttctgg
    12241 gacgtgtggg cgaagtcgaa ctgggagcct cggccattgc cggtgtatac tatctggcta
    12301 tttttatgat ggcattcgga ttcagtatag gtgcacaaat cctgattgcc cgtcgtaacg
    12361 gtgaacagca ataccaggct atcgggccca tcttttatca gggtgtctac tttctgcttt
    12421 cactcgcagt ggtagcattc actctttcgc tgtgcttctc accgcacata ctgaaaaagg
    12481 tcattagctc ggagcatata tacgatgcgt ccatcagcta catcaactgg agggtcttcg
    12541 gctttttctt ctcctttgtc ggagtaatgt ttcgtgcatt cttcgtgggt acaactcaga
    12601 ccaaaaccct gacactgaac tctgtggtca tggtattatc caatgtggtg ttcaactaca
    12661 tactgatttt cggtaagttc ggtgctccac agttaggtat cgccggagcc gccatcggtt
    12721 cgtcactggc cgaaatggtt tcggtcatct tcttcgtcat ttacacctgg agacggatag
    12781 actgtaaaaa gtatgccttg aatcatctgc ccggattccg gccggagatg ctgaaacgga
    12841 tcctgaacgt atccttttgg acaatgattc agaacttttt ctcactgtcc acttggttca
    12901 tgttcttcct atttgtcgaa cacttaggcg aacgtgcact ggccataacc aatatcatcc
    12961 gtaacgtatc gggcatcccg tttatggtca ccatggcatt tgcagctact tgcggctccc
    13021 tggtgagtaa cctgatcggt gcgggcgaaa tcaagtgtgt tcccggaacg atccgccagc
    13081 acatccgtat cggttatatt ttcgtgctgc cgctggttat actcttcgca ctgtttccta
    13141 acctgatatt gagtatctat acggatattc ccgatttgcg ggaggcctcc atcccttctt
    13201 tatgggtact atgctccgct tatctgatac tcgtacctgc caacgtctat tttcaggcag
    13261 tatccggaac aggcaacaca cgtacggcgt tgggattgga actctgtgta ctggccattt
    13321 atctgatcta tatcacctat atgattctct atctgagagt ggatgtagcc gtctgctgga
    13381 ctacggaaca tctgtacgga atctgtatcc tgttcctttc atacctttat ataaagaaag
    13441 gaaactggca gaaaaagcag atttgacctg atttttgctt atcttcgcag cactattatg
    13501 gaagagaaca caagtaaatt actaattatt aaaataacta tgagacaagt aaacctattt
    13561 attatgtcgg cagcaatgat gttagcatct tgtggtggaa ccaaagatgc aggcaaaaca
    13621 gatcaggcgc tgatcggtaa atccgatatc aagatcgaag gaaagcggat gactcccgaa
    13681 gcgctttggg cgatgggacg tatcggcgga ctggccgtat cgcctgacgg aaagcaaata
    13741 gcctatactg tggcttatta cagtgtcccc gagaacaaga gcaaccggga agtttttgtg
    13801 atgaatgcgg atggaacgga taatcgacag attacccaca ctccttatca ggaaaatgaa
    13861 gtgacttggg tggcagacgg aagcaagctg ctcttcctga gcaacgacaa cggcagcagc
    13921 caactgtatg aaatgaatcc ggacggtagc ggacgcaagc agatctccaa gtatgacgga
    13981 gacatcgagg gatattccat ctcaccggac ggtaaaaaga tactcttcat cgctcaagtg
    14041 aaaacagtaa agagcacggc tgataaatac cccgacctgg ataaagcgac cggaatcatc
    14101 atcaccgacc tgatgtataa acattgggac gaatgggtga ccaccgctcc acatcctttc
    14161 atcgccgact ttgatggcaa atcaatctcc aacatcatag atgtgctgga aggagaacct
    14221 tacgaaagcc cgatgaaacc ttggggaggt atcgaacaat tggcttggaa tacgacttcg
    14281 gacaaggtgg cttatccctg ccgcaaaaaa acgggactgg cttatgccat atctaccaac
    14341 tcggatatct atgtatatga cctgaatacc aagaaaacaa taaacatcac cgaaggtatg
    14401 atgggttatg atacaaaccc gcaatattct ccggatggaa aaagcattgc ctggcaaagc
    14461 atggagcgcg acggttacga agctgaccag aaccgcctct tcgtcatgaa cctggaaacg
    14521 ggcgagaaac gttttgtaag taaagctttc gattcgaatg tagatgcatt cgtatggagc
    14581 cgggatgcca agacgatcta cttcaccggt gtatggcatg gcgagacaca aatttattca
    14641 ctcgatctgg ctaacgattc cgtacgcccc gtcacttcgg gtatgtacga ctacgaaggc
    14701 gttgccctct tcggagacaa actgattgcc aaacgccatt caatgagtat gggtgacgaa
    14761 atttacgcaa tagctttgga cggacaaacc acgcaactga cccaagagaa caagcaaatc
    14821 tatgaccaga tcgaaatggg taaagtagaa ggccgctgga tgaaaacaac tgacagcaaa
    14881 gagatgctga catgggtcat ctatccacct caattcgatc cgaataagaa gtacccgaca
    14941 ctgcttttct gcgaaggtgg tcctcagagt ccggtaagcc agttctggag ttatcgttgg
    15001 aacatgcaga ttatggccgc caacggttat atcgtcgtag ctccgaatcg tcgcggactt
    15061 ccgggcttcg gattggaatg gaacgaggct atcagcggtg attacggtgg tcaatgtatg
    15121 aaggattatt tcacggctat cgacgaaatg gccaaagagc cgtttgtgga tagtgatcgt
    15181 ctgggttgtg taggtgccag cttcggagga ttttctgtgt attggttggc cggacatcac
    15241 gacaagcgct tcaaggcatt cattgcccac gacggtatct tcaatatgga aatgcaatat
    15301 ctggagacag aagaaaaatg gtttgccaac tgggatatgg gcggcgctta ctgggaaaaa
    15361 cagaatccga cagcccaacg tacatttgcc aattctcccc atttgtttgt cgaaaaatgg
    15421 gatactccaa ttctctgtat ccacggtgag aaagactacc gcatccttgc caaccaggca
    15481 atggctgcat tcgatgctgc cgtgatgcgt ggtg
//
