LOCUS       c00342_gnlPro..        14380 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KGFGMFNE_447.
ACCESSION   c00342_gnlPro..
VERSION     c00342_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-03 17:45:19
            Original ID  :: gnl|Prokka|KGFGMFNE_447
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14380
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14380
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[168:4380](+)"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      169..4380
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     cand_cluster    1..14380
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /kind="single"
                     /product="Others_HGD_unassigned"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14380
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Others_HGD_unassigned"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /tool="gutsmash"
     CDS             169..4380
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg342_1"
                     /sec_met_domain="HGD-D (E-value: 1.2e-21, bitscore: 67.4,
                     seeds: 370, tool: rule-based-clusters)"
                     /sec_met_domain="BcrAD_BadFG (E-value: 3.7e-34, bitscore:
                     108.0, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNAYKVGLDIGSTTTKMVVLDKDGTTVLFSGYKRHQAKIQECLLG
                     FLYQIKEQLGDIPLSFHITGSVGMGISEKCSLPFVQEVVAATNYVRREHPHTATMIDIG
                     GEDAKVVFFQDGQATDLRMNGNCAGGTGAFIDQMAILLGVSIDELNELALRSNQVYSIA
                     SRCGVFCKTDIQNLMAKNISKENIAASIFHAVAVQTTVTLARGCNIVAPVLLCGGPLTF
                     IPALRKAFANYLNLSQDTDFILPEKGNLIPAWGAALAENNEESIHLSNLIQVIENKLSV
                     TSPFQSDLSPIFDSEEEYRSWKKEKDQYKIQYASLRPGLQEATIGIDSGSTTTKIVVLD
                     NNHRILYSYYHDNNGNPIKTVENGLQKLYEECRRRGTTLRIKGGCSTGYGEDLIKAAFH
                     MDAGIIETIAHYAAAKHISKEVSFILDIGGQDMKAIFVNDGVINRIEINEACSSGCGSF
                     ISTFAQSLDYSVEDFAKAACFSQAPCDLGTRCTVFMNSKVKQVLREGASVADIAAGLSY
                     SVVKNCLYKVLQLKDTEILGDHIVVQGGTMRNDSIVRSLEKLTGKQTFRSNCPELMGAL
                     GCALYAKQIENARVTELNEMLQWAQYTSKQLQCRGCENQCAIMRYTFNSENHYFSGNRC
                     EKVFSNKGSHADKGINTYDKKLELLFDRSADIPQPLFTIGIPRILNMYEEYPFWHTLFT
                     ACGIQVQLSEPSTFSKYETAAGMVMSDNICFPAKLVHSHIRNLTLQNVNRIFMPFVVFE
                     KKDKQQQNSYNCPIVSGYSEVIKSVQEENIPIDAPTITFKDEALLYKQCYEYLKSLGIR
                     DEVYKNAFSRALQEQYAFEEKIAAYNQEVLNEGREKHKLIILLAGRPYHSDPLIQHKVS
                     DMIAAMGVYVITDDIVRQQEISLEKTHYLSQWAFTNRILKATKWAAMQEGDIQYMQMIS
                     FGCGPDAFLIDEVRNLLKRYSKNLTLLKIDDVNNIGSIKLRVRSLVESLNFSLKHSQTK
                     DPEPFVSTAPFTKKDKKKKILAPFFTPFISPLIPSIMKVAGYEMETLPLSDTASCDWGL
                     KYSNNEVCYPATLIVGDIVKAFKSGRYDPANTCVAITQTGGQCRASNYISLIKKALIEN
                     GYTNTPVVSLAFGSGIENEQSGFKVNWLKVLPIILASVLYSDCIAKFYYAAVVREKERE
                     QAARLRDLYLDTAQPIIQKNKPEDLLSYLYLAARDFNKICEQRSCHKVGIVGEIFLKFN
                     PFAQKDVTSWLINQKIEVIPPLISDFFMQGFVNLKVRQNQHLQRKLTPDFVIDWLYKKV
                     QKQINKVNEIGKSFNYFIPFESIFEKAEKAKQVISLGTQFGEGWLISGEILSFASQGVN
                     HVISLQPFGCIANHIVEKGIEKRIKSLCPQMNILSLDFDSSVSDVNITNRLLLFIDNIN
                     N"
     CDS             4385..5005
                     /locus_tag="ctg342_2"
                     /transl_table=11
                     /translation="MATTEHSDLEQQIIKTAQQLFIEKGFVETSMSDIAATVGINRPTL
                     HYYFRTKDKMFKAVFGSIVMSLMPKIQDIVKQDIPFMERLSMILDEYIELFTSNPCLPR
                     FICGEIQRDVNHLLATAKELQFGDALSQVKDSILTAMEDGKLKKVPIHIVFLTVYSLLS
                     YPFLAKNLIVSLFLEDEAAFADFLQEWKQNIINQLQNLLCYEK"
     CDS             complement(5086..5508)
                     /locus_tag="ctg342_3"
                     /transl_table=11
                     /translation="MMRDAEKTVGNMIDKLKTAFIGSIDGEGFPTIKAMLQPRKREGIK
                     TIYLTTNTSSMRVAQYRENNHACIYFCDTRFFRGVMLRGMMDVLTDSASKEMIWQEGDT
                     MYYPEGVTDPDYCVLKFTAISGRFYSNFKSEDFVVE"
     CDS             complement(5601..6479)
                     /locus_tag="ctg342_4"
                     /transl_table=11
                     /translation="MKNSIPRYTFYKHKYGSELLVDVVELKYVKKFLTKSTVHTLNYYD
                     ITFITEGKGAFAVDNQTYEAIPCDVLFSKPGEIRNWDIHHIINGYALIFEEEFLSFLFK
                     DSLFVQHLSFFQIESSSSLLHLSDELYTRILETLHDIKMEIDSYQQGDVHVLRALLYEV
                     LMLLDRAYLKMISMEEGRSREVFNNHVSKFMNLVATHAKEQHSVQYYADKLCITPNYLN
                     EMITSTMGFSAKQYIQGKVMEEAKRLLVYTDFPIADIAFELCFSTVSYFIRSFRQHTGK
                     TPLLYRKAHKP"
     CDS             complement(6603..7151)
                     /locus_tag="ctg342_5"
                     /transl_table=11
                     /translation="MEAYLKKLCFEYQVDEREVKELLARMEMVYLDKGETIASATLPEQ
                     SLYIIVSGILHTYTTHEGEERTNRFFSAGDAVLCYNSSQYSIKTLTKCAAYYISEEEIE
                     ELCASSISFANLVRQLMEYQFYFKEEEDMNARKLTVRERYLSLLAEIPDILYRVPLKHI
                     NHYLGADVTSLGYLAGSSK"
     CDS             complement(7192..8556)
                     /locus_tag="ctg342_6"
                     /transl_table=11
                     /translation="MKELDLTQGSVPKVLLQFAVPFLIANVLQALYGGADLFVVGQYDD
                     SASVAAVAIGSQVMQTITGIILGITTGTTVLIAIAIGAKDNRKVAFTIGSSVWLFSITG
                     VVLTLVMVLFHSRIAELMHTPVEAMVDTKNYILVCSLGILFIVGYNVVCGILRGLGDSK
                     TPLYFVGLACVINIVLDFILVGYFHWGATGAAIATVTAQGVSFGIALWFLYRHGFHFDF
                     SRKDIRLNRNLSKKILVLGAPIALQDALINVSFLIITVIVNQMGVIASASLGVVEKIIV
                     FAMLPPMAISSAVATMTAQNYGAGLIKRMNKCLASGIGIALVFGVSVCVYSQFLPETLT
                     AFFTKDAAVVAMAADYLRGYSIDCIVVSFVFCINSYFSGQGNSLFPMIHSLIATFLFRI
                     PLSYWFSQIDSSSLFIMGFAPPISTVVSLLICIWYLRYTQRKLYLSGTMMPAMSN"
     CDS             complement(8794..10359)
                     /locus_tag="ctg342_7"
                     /transl_table=11
                     /translation="MENESSLLSFRHIYYRGKLNSCNYTCSYCPFGKKSHLADTTQDEQ
                     IWNRFIAAIEQWKGEPLQLFIIPYGEVLIHRYYRKGMVHLAALPQVAGISCQTNLSFPA
                     KHWLDEIRVAPTVISKIRLWASFHPEMTSVEKFAHQIHILHHAGIQVCAGAVGSPSAKA
                     VLNDLRNALLPDIYLFINAMQGLKAPLSQEDIQFFSQLDNLFEYDLKNAPAQWEVCAGG
                     RDNCFIDWKGDMYACPRSRVKIGNFYQGDGAVVPLSCKRKVCDCYIAFSNLNNHPLHRI
                     MGEGAFWRIPDKPLITTVFFDVDGTLADSQGKVPESYANALRYMAQSVSLYLATSLSME
                     QAKKKLGKALFDLFRGGVFADGGLLSYSRQIKCLPVKVYPEVYGESSKVTIHSYEGVVY
                     KYSILVRDKEQRESILTRLKENPCQVFHKAPLITVIHPEASKKEGVLQLCKALGLASEH
                     TLVVGNSLKDWPMMSVVSHSCAVMNAEPLLKERARYTLNPDRLAAFFRFSNGDPIDQTS
                     SDNS"
     CDS             complement(10371..11648)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Radical_SAM"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg342_8"
                     /sec_met_domain="Radical_SAM (E-value: 2e-15, bitscore:
                     47.3, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNQPLPRYVDYMYSYPHKTAYRSFPSPVSLVPYLKQVEGQKASLY
                     FHIPFCSHKCGYCNLFSLQTNRADYIATYLETLHKQAQQLSPLTTGLAFDSFAIGGGTP
                     LLLTVPQLEYLLDTAALFGVHPSHTFTSVETSPEYADPARLDLLKQAGVARVSIGVQSF
                     LDEDLTALKRRPRRDMINQALEAIRKRQFPFFNIDLIYGIRRQTVASFLYSLEQALLFQ
                     PNELFIYPLYVRPGTAITERESDDVCFQMYCAACDLLKDRGFLQTSMRRFIHHPSTDAE
                     ISCGDEVMLSCGSGGRSYLGNLHYATRYTVCQRCIAGEIDDYMGTTDFTVARNGFILSQ
                     EERRQRFIIKNLMYYMGLDKAEYKRRFGESPDNVMLFRQLAERQWIENTDNGRVCLTSD
                     GMAYSDYIGQLFITPEIRELMETYSY"
     CDS             complement(11645..12499)
                     /locus_tag="ctg342_9"
                     /transl_table=11
                     /translation="MQIDELPAGEQTQNPDLDMNQVVGTHDILMLCFDTLRYDVSKEEE
                     EAGRTPVLNSHGGEWEKRHAPGNFTYPSHFAIFAGFLPSPAEPHSLRSRKWLFFPVQAG
                     TGRIPPAGSYPFTEATFVQSLANVGYETICIGGVNFFSKRNELGRVFPGYFTKSYWLPT
                     FGCTAPDSTEKQIDFALKKLENYPEDKRIFMYINFSAIHYPNCHYVEGKMKDDKESHAA
                     ALQYVDSQLPRLFQAFQKRGNTLVIALSDHGTCYGEDGYEYHCISHETVYTVPYKHFIL
                     TKK"
     CDS             complement(12486..13496)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg342_10"
                     /sec_met_domain="ATP-grasp_3 (E-value: 3e-08, bitscore:
                     23.6, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQIIVVSNSLSKRIEYFIEAGKHLQVEVRFMTYGELFNCLPQLRQ
                     AVIKLEPCVSDETNFLKYALLNQAYKETLQRLGEMRLSDDVCFLNTPHALLRALDKKET
                     KQVLMDRGLKVTPMLPSPRSFDELRELLTGCGRGCFLKPRYGSGAGGVMAVRYQPNRNK
                     WVVYTTLQQVDGVIHNTKRIHRLSTEKEMIPLAEAVMQTEAILEEWIPKEQLQGENYDL
                     RVVCRESEIDYIVVRCSKGSITNLHLNNKAHWWNELSLPEVVRQQIYFQCQEAVQSLDL
                     QYAGVDVLIERGTDIPYIIEVNGQGDHVYQDMFAHNSIYIQQIKNIKKRYNHANR"
ORIGIN
        1 tttatttaca caatcgtttt cctccctcac attccatctt tcttttttcc caattcgtta
       61 attaaaccca aaacttcaat tacgatttgc cgtatctacc atatttttac atacatttgc
      121 gtctgacata ggtgtcaaac acgaggtcta atttaagatg tttggtatat gaatgcatat
      181 aaagtgggtt tagatatagg ctctactacc actaagatgg tagtattgga taaagatgga
      241 actacagtct tgttttccgg atacaaaagg catcaggcaa aaatacaaga atgtttactc
      301 ggatttcttt atcaaataaa ggaacagttg ggtgatattc ctttatcttt ccacattacg
      361 ggctctgttg gaatgggaat ttcagagaaa tgctctctgc cgtttgtgca agaggttgta
      421 gctgcaacaa actatgtgcg ccgggagcat ccgcacacag ccactatgat cgatattgga
      481 ggagaagatg cgaaagttgt tttctttcag gacggacagg ctacagacct gcgcatgaat
      541 ggaaattgcg ccggcggaac cggggctttc attgaccaga tggctattct gcttggagtc
      601 tccatcgacg aattgaatga actagcactt cgttccaatc aggtatactc tatcgcttca
      661 cgctgcggag tattctgcaa aacggacata cagaatctga tggccaaaaa tatatctaaa
      721 gaaaatatag cagcttccat tttccatgca gtagccgtac agaccactgt cacacttgca
      781 cgcggttgca atatcgtagc tccggtatta ctctgcggtg gcccattgac ttttattccg
      841 gcccttcgga aagcatttgc caactatctg aatctgtcac aagatacaga tttcatatta
      901 ccggaaaaag gaaatctgat ccctgcctgg ggagcagcat tggcagagaa caatgaagaa
      961 agtattcatc tctccaacct gatacaggta atagaaaaca aactaagtgt tacctcacct
     1021 ttccagagtg atctttctcc tatattcgac agtgaggaag aatatcggtc atggaaaaaa
     1081 gaaaaagacc agtataaaat tcaatatgcc agtctgcgtc ccggattaca ggaagcaact
     1141 atcggcatag actccggctc tactaccacc aaaatcgtag tactcgacaa caatcatcgt
     1201 atcctttact cctattatca cgacaacaac ggaaacccta taaaaacagt agagaacggc
     1261 ttgcagaaac tatatgaaga atgccggaga cgaggaacta ccctgcgcat aaaaggagga
     1321 tgttctaccg gttacggaga agatctgata aaagcggctt tccacatgga tgcgggaatc
     1381 attgaaacca tcgctcatta tgctgctgcc aaacatatca gcaaagaagt ttcttttatc
     1441 ctggatattg gaggacagga tatgaaagcc atctttgtga acgacggagt aatcaacaga
     1501 atcgaaatca atgaagcctg ttcctccggt tgcggttctt ttatcagcac atttgcgcaa
     1561 tcgctggatt acagtgtgga ggactttgcc aaagcagctt gtttttcgca agcaccatgt
     1621 gatctgggta cacgttgcac agtcttcatg aactccaaag taaaacaggt acttcgggaa
     1681 ggagcgtccg tagcggatat agctgccgga ttatcttatt ccgttgttaa aaactgcctg
     1741 tataaggttc tgcaattaaa agacacggag atacttggcg accatattgt cgtgcaggga
     1801 ggaaccatgc gtaatgattc catcgtacga agtctggaaa agctgaccgg gaaacaaacc
     1861 ttccgcagta actgtcctga attgatgggt gctcttggtt gtgccctata tgccaaacaa
     1921 atcgaaaatg cccgggtgac ggagctgaac gagatgctcc aatgggcaca atatacttcc
     1981 aagcaacttc aatgccgggg gtgcgagaac cagtgcgcca ttatgcgata tacgttcaac
     2041 agtgaaaacc attacttctc cggcaaccgg tgtgagaagg tgttttccaa taaaggaagc
     2101 catgcggaca aaggcatcaa tacgtatgat aaaaagctgg aattattatt cgaccggagc
     2161 gcagatattc cacaacccct attcaccata ggtattccac gtattctgaa catgtatgag
     2221 gaataccctt tctggcatac cttatttact gcttgtggca ttcaggtaca gttgtcggaa
     2281 ccctctacat tcagcaaata cgagactgct gccggcatgg tgatgtctga taacatctgc
     2341 ttccctgcca aacttgtgca cagtcatatc cgtaacctga cactgcaaaa cgtcaaccgg
     2401 atatttatgc cgttcgttgt tttcgagaaa aaggataagc aacagcaaaa cagctataat
     2461 tgccccatcg tttccggtta ttcggaagtc atcaaaagtg tacaggaaga gaatataccg
     2521 atagatgctc cgactatcac cttcaaagat gaagcattgc tgtataaaca atgctatgaa
     2581 tatctgaaat ctttgggtat cagggatgag gtatacaaaa atgccttctc acgcgcatta
     2641 caggaacaat atgctttcga agaaaaaatt gctgcctata atcaggaagt tctgaacgag
     2701 ggacgggaaa aacacaaact gattatctta ctcgccggac gcccttacca tagcgatcca
     2761 ctgatacagc acaaggtttc ggacatgatt gctgcgatgg gagtttatgt gataactgat
     2821 gatattgtcc gccagcagga gatttcattg gaaaagactc attacctctc tcaatgggca
     2881 tttaccaacc gtattctgaa agcaaccaag tgggcggcaa tgcaagaggg tgacatacaa
     2941 tatatgcaga tgatttcttt tggctgcggt ccggatgctt tccttataga tgaagtacgt
     3001 aacttactga agcgatacag caagaatctt actttgctca agatagacga tgttaataat
     3061 atcggctcca tcaaattacg agtccgctcg ttggtggaaa gcttgaattt cagtttgaaa
     3121 cattctcaaa cgaaagatcc cgagccattt gtttcaactg ctcctttcac caagaaagac
     3181 aaaaagaaga aaatcctcgc tccatttttt acgcctttca tctcaccact cattccgtcc
     3241 atcatgaaag tggccggata tgaaatggag actttaccgt tgagcgacac cgcatcatgc
     3301 gactggggat tgaaatactc caataatgaa gtatgttatc cggcaacatt gattgtcggc
     3361 gacatagtaa aagcctttaa aagcggacgt tatgatcctg ccaatacgtg cgttgccatc
     3421 acgcaaaccg gtggacaatg tcgtgccagc aactatattt cactgataaa aaaggcattg
     3481 attgagaatg gatacaccaa tacaccggtg gtatcacttg ctttcggcag tggtatcgaa
     3541 aatgagcaat ccggttttaa ggtaaactgg ctcaaggttt taccaatcat acttgcgtct
     3601 gtgttataca gtgattgcat tgccaaattc tattatgcag ctgtcgttcg tgagaaagaa
     3661 cgggaacagg ccgcccgtct gcgcgatctt tatctggata cagcacagcc catcatccag
     3721 aaaaataaac cggaggactt gttgagctac ttatatctcg ctgccagaga cttcaacaaa
     3781 atctgtgaac agagatcctg tcacaaagta ggtattgttg gggaaatatt cctgaagttc
     3841 aacccttttg ctcaaaagga cgtcacctca tggctcatca accagaagat cgaagtgatt
     3901 ccgccactga taagtgattt cttcatgcag ggatttgtca acctgaaagt gagacagaac
     3961 caacacttgc agcgaaaact cactcccgac tttgttatcg actggttata caagaaagtc
     4021 cagaagcaga ttaataaagt gaatgaaatc ggcaaaagtt tcaattactt cataccgttc
     4081 gaatctatct ttgaaaaggc agaaaaagct aaacaagtca tctccttggg cacccagttt
     4141 ggagagggtt ggctgatatc cggtgaaata ctatcctttg cttcccaagg agtcaatcat
     4201 gtcattagct tgcaaccttt cggatgcatt gccaatcaca ttgtagaaaa aggaatagaa
     4261 aaacgtataa aatcgctgtg ccctcaaatg aatatactat ctttagactt tgacagtagc
     4321 gtcagcgatg tgaacataac aaacagatta ttacttttta ttgacaacat aaacaactaa
     4381 aattatggct acaacggaac atagcgattt agagcagcaa ataataaaaa ctgcccaaca
     4441 actttttata gaaaaaggat ttgtggagac cagcatgagt gatattgctg caacggtagg
     4501 aatcaaccgg cccactttac attattattt cagaaccaaa gataagatgt tcaaagccgt
     4561 gttcggctcg atagtcatgt ctttaatgcc gaaaatacag gatatagtaa aacaggatat
     4621 cccatttatg gagcgactaa gcatgattct ggatgagtat attgagcttt tcacaagtaa
     4681 tccctgtctt cccagattca tttgcggaga aatacagcgt gatgtaaacc acttgcttgc
     4741 cactgcaaaa gaacttcagt tcggagatgc tttatcccaa gtgaaagaca gtatactgac
     4801 agcaatggaa gacggtaaac ttaaaaaggt tccgatacat attgtatttc tgactgtcta
     4861 cagcctattg agctatccat ttcttgccaa gaacctgata gtatctttat tcttggaaga
     4921 tgaagccgct tttgctgact tcctgcaaga atggaaacaa aacatcatca accaattgca
     4981 gaacttattg tgttatgaga aatagtatag acactataaa caaaaagaga ctgaatattc
     5041 agtctctttt tgtttattac cattccaatc accccatctt gcaccttatt cgaccacaaa
     5101 atcttccgat ttaaaattac tatagaaacg tcctgaaata gcagtaaact tcaatacaca
     5161 gtaatcggga tccgtcactc cctccggata atacatggta tctccctcct gccagatcat
     5221 ctctttactg gcactatccg tcaagacgtc catcataccg cgtagcatga cccctctaaa
     5281 gaatctcgta tcgcagaagt agatacatgc atggttgttc tcccggtatt gcgccacacg
     5341 catggacgaa gtatttgttg tcagataaat cgtttttatc ccctctcttt ttctgggttg
     5401 cagcattgct ttgatggtag gaaatccttc accgtctatc gaaccgataa aagctgtttt
     5461 cagcttatca atcatgttgc ctactgtttt ttccgcgtct ctcatcattt tactttttat
     5521 tattggttta ttatctgatg cgaaagtaga gaaatgccag gaaagcaatg caataaaaag
     5581 aaaggtagaa atagcacttt ttacggtttg tgtgctttac gatacaataa cggagttttt
     5641 cccgtatgct gtcggaagct acggataaaa taagaaaccg ttgaaaaaca gagttcaaat
     5701 gcaatatcag ctataggaaa gtccgtataa acaagcagcc tcttggcctc ttccatcacc
     5761 ttgccctgaa tatattgttt tgcgctgaac cccatggtcg aggttatcat ctcattgaga
     5821 tagttaggag taatgcagag cttatccgca taatattgaa ccgaatgttg ctcttttgca
     5881 tgtgtcgcaa ccaaattcat gaatttactt acatgattat tgaaaacttc cctacttctg
     5941 ccctcctcca tcgaaatcat tttaagataa gcacgatcca gcaacatcag gacttcataa
     6001 agcaatgctc tcaaaacgtg tacatcgccc tgttgatacg aatcaatctc catctttata
     6061 tcatgcaagg tttcaagtat gcgtgtataa agctcatcag acaaatgtag tagcgatgaa
     6121 gaactttcta tctgaaaaaa cgaaagatgc tgtacaaaca aagaatcttt aaagaggaaa
     6181 gacaaaaact cttcttcgaa aatcagagca tacccattga tgatatgatg aatatcccag
     6241 ttccggattt cccccggttt agaaaaaagg acgtcacatg gaattgcttc ataggtttgg
     6301 ttatcgactg caaaagctcc cttaccttct gttataaaag taatatcata ataatttaga
     6361 gtgtggacag tacttttagt caggaacttc ttcacatact tcagttctac tacatcgacc
     6421 aaaagttcac tcccatactt atgcttataa aaagtatatc gaggtattga gtttttcatt
     6481 cagaatacaa aaatagtatt ccttaccaaa taatccaaag acttttcaaa ttcgattcga
     6541 ttgaataagc catgaaccat ctgataagga atacatagaa aaatatgtct aggttatatt
     6601 tcctatttag aacttccggc cagatatccc aaactggtca catctgcccc caagtaatga
     6661 ttaatgtgct tcaatggcac cctgtacaga atatctggaa tttccgccaa taaagagagg
     6721 tacctttccc ttactgtcag cttgcgggca ttcatatcct cttcctcttt aaagtaaaac
     6781 tgatactcca tcagttgacg gaccagattc gcaaatgaaa ttgaagatgc acacaactct
     6841 tcaatctcct cttcactgat gtaataagca gcacatttcg tcagtgtctt gatagaatac
     6901 tgacttgaat tatagcataa cacagcatca cccgcagaga aaaaccgatt ggttctctct
     6961 tctccttcat gagtggtata tgtatgcaaa ataccggaaa caataatgta caagctctgc
     7021 tctggcaatg tggcagaagc aatcgtttct cctttatcca gatacaccat ttccattcga
     7081 gccaacagct ctttcacttc tctttcatcc acctgatact caaaacagag tttcttcaaa
     7141 taagcttcca tacaaaatag attttagtta atatatgtca cttaaaaaca cctaattcga
     7201 catagcaggc atcattgtgc cactcaaata taatttcctt tgggtatatc gtaaatacca
     7261 gatacagatc aataatgaaa cgaccgttga aatgggtgga gcaaatccca tgataaacag
     7321 cgacgagcta tctatctggc tgaaccagta tgacaacggt atacggaaca ggaaagtggc
     7381 tatcagactg tgaatcatcg ggaataacga gtttccttgt ccgctgaaat aagaattaat
     7441 gcagaacacg aaactaacca cgatgcagtc gatgctatac cctcgcaaat aatctgccgc
     7501 cattgccacc acagcagcat ctttcgtaaa gaaagcagta agagtctccg gcaggaattg
     7561 cgaatacacg caaaccgaca caccgaaaac aagagcaatc ccaatccccg aagccagaca
     7621 tttattcatt ctcttgataa gtcccgctcc atagttctgt gcagtcatgg ttgccacagc
     7681 cgatgatata gccatcggag gcagcatagc aaacacaatg attttctcaa caacccccag
     7741 ggaagcagat gcaatgactc ccatctgatt gacaatgaca gtgataatca gaaaagaaac
     7801 attgattaaa gcatcctgca aagcaatagg tgctcccaac accaagatct ttttagacag
     7861 attccggttc aatcgaatat ctttccgtga aaagtcaaaa tggaatccgt gccggtataa
     7921 gaaccagagc gctattccaa agctgactcc ttgtgcagtt acagtagcga tagccgctcc
     7981 cgtagccccc caatggaaat aaccgaccaa tataaaatcg agcactatat ttatcacaca
     8041 tgccagccca acaaaataaa gtggtgtttt agaatcaccc aatccacgca aaataccaca
     8101 tacaacatta tatcctacta taaacagaat acccagagag cataccaaaa tatagttttt
     8161 cgtatctacc atcgcttcga caggagtatg catcagttct gctatccgac tatgaaaaag
     8221 caccatgacc aaagttagca ctacgccggt tattgaaaac aaccatacgg aagacccgat
     8281 agtaaaagct actttccgat tgtctttagc tccgatagca atagcaatca gcactgttgt
     8341 cccggtagta atacccagaa taatacctgt aattgtctgc atcacctgac taccaatagc
     8401 tacggctgcc acacttgccg aatcatcata ttgtccgaca acgaaaaggt cagctccgcc
     8461 ataaagtgcc tggagcacat tggcaatcag aaaaggtact gcaaactgca acaatacctt
     8521 cggtacgctt ccttgtgtca aatctaactc tttcatagtt tcttcgatac ttttcctctt
     8581 tatcttattt tgttacaaca taaaaaaagt gccggacaag cgaatgattt gcaccattca
     8641 tcttatccag cactataatt attattatag caccctccga tgaggatttt tatgcctgtc
     8701 cctatttcag ggctgcaaat atgggctttg ttttcataat taccaaattt taaccggctt
     8761 ttattttctt atgaagatgt aactagctat atatcaacta ttatcagacg aggtttggtc
     8821 tataggatct ccgttagaaa aacgaaagaa agctgccaac cgatccggat tcagcgtata
     8881 acgtgcgcgt tcttttaata agggttccgc attcattacg gcacaagaat gagaaaccac
     8941 ggacatcatc ggccagtcct ttaacgaatt tcctacaact aaagtgtgtt cagaagctaa
     9001 acccaaagcc ttacataact gaagcacccc ctctttttta ctcgcttcag gatgaatgac
     9061 tgttatcagc ggagctttat gaaagacctg gcagggattt tctttcaacc gggtaagaat
     9121 agattctctc tgttctttat cacgtaccaa tatactatac ttgtaaacca ctccttcata
     9181 actatgaata gtaacttttg acgattctcc atatacctcc ggatatactt tcaccggcaa
     9241 acacttaatc tgccgcgaat aagataataa acctccatct gcaaacactc ctcccctgaa
     9301 taaatcgaaa agagcctttc ccagcttttt cttcgcctgc tccatcgaca gagaagtggc
     9361 aagatataag gaaacggact gtgccatata tcgcaaagcg ttagcataac tttctggaac
     9421 ttttccctgt gaatcagcca gtgttccatc cacatcgaag aaaacagtcg taataagtgg
     9481 cttgtccggg attcgccaga atgccccttc tcccattatt cgatgtaaag ggtgattgtt
     9541 caggttacta aatgcaatat aacagtcaca aaccttcctc ttgcaagata acggcacaac
     9601 agctccatca ccttgataaa aattacctat cttcacccgg cttcggggac aagcatacat
     9661 atcccctttc caatcgataa aacaattatc ccttcctcct gcgcaaactt cccattgtgc
     9721 cggagcattc ttcaagtcat actcaaaaag attatccagt tgactgaaaa actgaatatc
     9781 ttcctgactt aatggtgcct ttaacccttg catagcatta atgaataaat aaatatccgg
     9841 caaaagagca ttccgtaaat cattgagtac ggcctttgca gagggacttc ctaccgctcc
     9901 ggcacatacc tgtattcccg catgatggag tatatgaatc tgatgcgcaa atttctctac
     9961 cgaagtcatc tcaggatgaa aactagccca aagccttatc ttacttatca cagtgggagc
    10021 cacacgaatc tcatcaagcc agtgtttagc cggaaaagaa aggttagtct gacaggaaat
    10081 tccggccacc tgtggcaatg ccgccaaatg caccattcct ttccgataat aacgatggat
    10141 caatacttca ccgtaaggaa taataaataa ctgcaacggc tcccctttcc attgttcaat
    10201 agctgctata aaacgattcc atatctgttc atcctgtgtc gtatctgcca gatgcgactt
    10261 cttgccgaaa gggcaataag aacaggtata gttgcagcta ttcaatttgc cgcgataata
    10321 tatatgcctg aaggaaagta aagagctttc gttttccatt tctatttcgt tcaataagaa
    10381 taagtttcca tcagttctct tatttcagga gtaatgaaca actgaccaat ataatcggag
    10441 tatgccattc cgtcggaagt cagacaaaca cgaccgttat ccgtattttc tatccattgc
    10501 cgttcagcta actgtcggaa caacatcaca ttatccggtg attctccaaa gcgacgctta
    10561 tattcggcct tatcaagccc catataatac atcagatttt taatgatgaa acgttgtcgc
    10621 cgttcttcct gagaaagaat aaatccatta cgagccactg taaaatcagt agtgcccata
    10681 taatcatcta tctctccggc aatacaacgc tggcaaacag tataccgggt ggcataatgc
    10741 aaattaccca ggtaactgcg tccgccggag ccacacgaca gcatcacttc atccccacat
    10801 gagatttccg catcagtaga cggatgatga ataaaacgtc gcatcgaagt ttgtagaaag
    10861 cctctgtctt tcaacaaatc acaagcggca caatacatct gaaaacagac atcatcggat
    10921 tcccgctctg tgatagccgt tcccggtcgc acatatagcg gatagataaa gagttcgtta
    10981 ggctgaaaca gaagagcctg ttccaatgaa taaagaaagc tggccacagt ttgtcttctg
    11041 attccgtaaa tcaaatcaat attaaaaaac gggaattgtc tcttccgaat agcctccagc
    11101 gcctgattaa tcatgtctcg ccggggacgt cttttcaaag cagttaaatc ttcgtcaagg
    11161 aaactctgta cgccaatact cacacgagcc actcctgctt gcttcaataa gtccaaacgg
    11221 gcaggatcgg catattccgg cgatgtttct acggaagtaa aggtatgtga aggatgcact
    11281 ccgaataagg cagctgtatc cagtaagtat tccagttgag gaacagtgag gagcaacggt
    11341 gtgcctcctc caatggcgaa actatcaaat gccagtccgg tagtgagtgg agacaactgt
    11401 tgcgcctgct tgtgaagagt ttccaaataa gttgcgatat aatccgcacg atttgtttgc
    11461 agagaaaaca ggttgcaata tccacattta tgactacaaa aaggaatatg gaaataaagc
    11521 gatgctttct gtccttccac ctgtttcagg taaggaacca gcgaaaccgg ggacggaaaa
    11581 gaacgataag cagttttatg tggataacta tacatatagt ctacatatcg tggtagcggt
    11641 tgattcattt tttcgttaaa ataaagtgtt tgtaagggac tgtataaacc gtttcgtgag
    11701 atatgcaatg atattcatat ccatcctctc catagcaagt gccatgatcg gaaagagcaa
    11761 tcaccagcgt atttccccgc ttctgaaagg cctgaaataa acggggtagc tgactgtcga
    11821 catattgcag cgcggcagcg tgtgattcct tatcatcctt cattttgcct tccacataat
    11881 gacagttcgg ataatgaata gcagaaaaat tgatatacat aaaaatccgt ttgtcctccg
    11941 gatagttttc gagtttcttc aatgcaaaat caatttgttt ttcagtacta tcgggtgccg
    12001 tgcatccaaa ggtcggcagc caataacttt tagtaaagta accgggaaac acacgcccca
    12061 gttcattacg cttgctgaag aagttcaccc ctcctataca aatcgtttca taacctacat
    12121 tggcaaggct ttgcacaaaa gttgcttccg taaacggata acttcccgca ggcggaatac
    12181 gtcccgtacc agcttgcaca gggaaaaaca accacttacg gctgcgtagc gaatgaggtt
    12241 ccgccggaga aggcagaaat cctgcaaaga tggcaaaatg agacgggtaa gtaaaatttc
    12301 ccggcgcatg tcttttttcc cattctcctc cgtgactgtt cagtaccggt gttcttcctg
    12361 cctcttcttc ctccttgctg acatcataac gcaaggtatc aaagcaaagc atcaatatat
    12421 catgagtacc caccacctga ttcatatcca gatccggatt ttgggtctgt tcgccagccg
    12481 gcagttcatc tatttgcatg gttatatctc ttttttatgt tttttatctg ttgaatataa
    12541 atagaattat gagcaaacat atcctgatac acatgatctc cctgtccgtt gacttctatt
    12601 atataaggaa tatctgttcc tctctctatc agtacatcca ctccggcata ctgcaaatcc
    12661 aaagattgaa ccgcttcctg acactgaaaa tagatttgtt gccgcactac ttccggcaaa
    12721 gacaattcgt tccaccaatg tgccttattg ttcagatgca gattggttat gcttccttta
    12781 ctgcatctca caacgatata atcaatttca gattcccggc acactacccg gagatcataa
    12841 ttctctccct gcaactgctc tttaggaatc cattcttcta aaatagcttc tgtttgcatc
    12901 accgcttccg ccaacgggat catctctttt tccgtactca aacggtggat acgtttggtg
    12961 ttatgaatga ctccatccac ttgttgcaag gtagtataga ctacccattt attccggttg
    13021 ggttgatagc gaacagccat aacgcctccc gcccccgaac cgtaacgggg ttttaaaaag
    13081 catcctctcc cgcaaccggt aagaagctct ctcaactcat caaaagaacg gggagaaggt
    13141 aacatcggag tcactttcaa ccctctgtcc atcaacactt gtttagtttc ctttttatca
    13201 agagcacgta ataaagcatg gggagtattc aaaaagcaca cgtcatcaga taacctcatc
    13261 tcgcctaaac gttgcagtgt ctccttatat gcctgattca acagcgcata tttcaggaaa
    13321 ttcgtttcat cgcttacaca aggttccagt ttgataactg cctgccgtag ttgcggcaag
    13381 cagttaaaaa gttccccgta agtcataaaa cgaacttcca cctgcaagtg tttgcctgct
    13441 tcaataaagt attctatacg tttggacaga gagttgctga caacgattat ctgcatctcc
    13501 tattctgtaa tcatcgggta ataccacaat tcaccatcat attcatctgc ctcttcagtt
    13561 tcagcaatat ctattttcat agggagactc tgcaactgtt tcttcatctc cttgctcaaa
    13621 taattatagc gcatattgat aaacttcaaa tgagcgatct tatccatatt atccagcaat
    13681 aattgggcac cttcatcttt gagagtacca gccgaaacat ccattgtttc aagttgggga
    13741 agaatatctg actccaggaa catttctaca atcttgtcct gttcttcaga gttgacgatc
    13801 cccagataag tcagcttcgg gaaacgttct ttggagaaca acggacggaa tatctcaata
    13861 tcagcttcaa atccataatc ttccacacca acatatagaa tcagtttttc cagattgggg
    13921 aaatcagaac caaaaatatc ttctaccact tcggtaggca ggccaccact gataatttcg
    13981 agtgaccgca actccggccg tgaagtcttt cccaaacgca gattattggt tcctttgatt
    14041 ttcagatctt tcaatttagg catggcatcg agcagcggac taatatcagc ttgttcaatc
    14101 catgaaatct cctgttcttc ctgctcaata tctccccaga acaagccttc tatttgtgcg
    14161 aacttctcct tattttcaat cattccctgt aataaggcag aacagtcgcc accctcataa
    14221 tcccaacaac cgattgttat ttgtttatat tcagagagat gtttatcttt caatatctta
    14281 tccagaagat tcacattgtt ttcatactca tcataactca aagtatattt cttggcttcc
    14341 actttcattt cacgtgcagt ttcttcagca gtttctacat
//
