LOCUS       gnlProkkaHFNFGPLJ_88    3036 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HFNFGPLJ_88.
ACCESSION   gnlProkkaHFNFGPLJ_88
VERSION     gnlProkkaHFNFGPLJ_88
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 02:56:39
            Original ID  :: gnl|Prokka|HFNFGPLJ_88
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 3036
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..3036
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[2:2795]"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3..2795
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     cand_cluster    1..3036
                     /SMILES="NC(Cc1ccc(O)cc1)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..3036
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX))"
                     /tool="antismash"
     CDS             3..2795
                     /NRPS_PKS="Domain: AMP-binding (1-259). E-value: 1.4e-74.
                     Score: 243.0. Matches aSDomain:
                     nrpspksdomains_ctg60_1_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (366-433). E-value: 1.2e-27. Score:
                     87.8. Matches aSDomain: nrpspksdomains_ctg60_1_PCP.1"
                     /NRPS_PKS="Domain: Epimerization (443-755). E-value:
                     3.3e-156. Score: 513.0. Matches aSDomain:
                     nrpspksdomains_ctg60_1_Epimerization.1"
                     /NRPS_PKS="Domain: TIGR01720 (767-923). E-value: 1.3e-45.
                     Score: 146.8. Matches aSDomain:
                     nrpspksdomains_ctg60_1_TIGR01720.1"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     273.3; E-value: 5.5e-83)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg60_1"
                     /sec_met_domain="AMP-binding (E-value: 5.3e-95, bitscore:
                     305.4, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 2.1e-18, bitscore:
                     53.9, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="Condensation (E-value: 3.1e-74, bitscore:
                     236.8, seeds: 42, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLAYIIYTSGTTGRPKGVMVEHKGIANTLQWRRNAYAFNETDTIL
                     QLFSFSFDGFITSMFTPLLSGAKAVLLHEEEAKDILAIKHQLSRQRITHMIIVPVLYRA
                     LLDVVQPEDVKTLRVVTLAGEAADRELIDRSLAICPHTELANEYGPTENSVATTVMRHM
                     EKQAYVSIGQPIDGTQVLILNSNHQLQPIGVAGELCIAGTGLARGYVNLPELTERAFTQ
                     NPFKPETRMYRTGDAARWMADGTLEYLGRIDDQVKIRGYRVETKEIESVIRCINGVKDA
                     AVVAHVTASGQTELSAYVVTKPELSTNAVRSELQNKLPVFMHPAFIEKLDSLPLSPNGK
                     LDRGALPKPVYNHEGERPFLPPASKMEQILADIWKEVLGAEKIGTADSFFELGGDSIKA
                     LQVSARLHRIGKQMAVKDLFSHPTIQELAAYIRDSDTSSSQAAVEGDVQWSPVQKWFLS
                     QDIKEKHHFNQSVMLHRSTSVQEDALRKTLKAITCHHDALRMVFTQNEQGKWDQYNRPL
                     SHSDDALYGLQMIDLSAPDGTDGNRAYEPIIKRHVLDIQQKMDLKNGPLLQAGLFHTID
                     GDFLFLSAHHLVVDGISWRVLLEDLALGYRQAAGGEDIKLPPKTSSFKAYAKKLSDYAE
                     SQQLMKQLKYWREAEEYQTEALPFDQIDGTRAHEGQRSTISFTLNEKETAALLKDANSA
                     YNTDTQDMLLASVILALRHWTNQSAFKLSLEGHGREDVLEGIDVSRTIGWFTAIYPLLI
                     KLNADLPDSEEGMVHVLKTTKDTLRRVPDKGFGYGVIKYLTPPGKKDIDFTGAPEISFN
                     YLGQFESGRTAEVPEEDAFSFSPLGAGGDISTTWNREQSLDISAIAAEGKLTVNMTYDN
                     ARFQRKTIEQLSETCRQFLLQLIEHCQNKSETEKTISDYDDQELTEDALQEIADMLSFH
                     "
     aSDomain        6..779
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg60_1_AMP-binding.1"
                     /evalue="1.40E-74"
                     /label="ctg60_1_AMP-binding.1"
                     /locus_tag="ctg60_1"
                     /protein_end="259"
                     /protein_start="1"
                     /score="243.0"
                     /specificity="substrate consensus: Tyr"
                     /tool="antismash"
                     /translation="LAYIIYTSGTTGRPKGVMVEHKGIANTLQWRRNAYAFNETDTILQ
                     LFSFSFDGFITSMFTPLLSGAKAVLLHEEEAKDILAIKHQLSRQRITHMIIVPVLYRAL
                     LDVVQPEDVKTLRVVTLAGEAADRELIDRSLAICPHTELANEYGPTENSVATTVMRHME
                     KQAYVSIGQPIDGTQVLILNSNHQLQPIGVAGELCIAGTGLARGYVNLPELTERAFTQN
                     PFKPETRMYRTGDAARWMADGTLEYLGRIDDQVKIR"
     aSModule        6..2771
                     /complete
                     /domains="nrpspksdomains_ctg60_1_AMP-binding.1"
                     /domains="nrpspksdomains_ctg60_1_PCP.1"
                     /domains="nrpspksdomains_ctg60_1_Epimerization.1"
                     /domains="nrpspksdomains_ctg60_1_TIGR01720.1"
                     /locus_tags="ctg60_1"
                     /monomer_pairings="Tyr -> D-Tyr"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       9..68
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg60_1_0001"
                     /evalue="2.10E-11"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg60_1"
                     /protein_end="22"
                     /protein_start="2"
                     /score="35.5"
                     /tool="antismash"
                     /translation="AYIIYTSGTTGRPKGVMVEH"
     CDS_motif       573..662
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg60_1_0002"
                     /evalue="2.00E-15"
                     /label="NRPS-A_a6"
                     /locus_tag="ctg60_1"
                     /protein_end="220"
                     /protein_start="190"
                     /score="48.9"
                     /tool="antismash"
                     /translation="PIGVAGELCIAGTGLARGYVNLPELTERAF"
     CDS_motif       744..809
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg60_1_0003"
                     /evalue="2.40E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg60_1"
                     /protein_end="269"
                     /protein_start="247"
                     /score="35.6"
                     /tool="antismash"
                     /translation="YLGRIDDQVKIRGYRVETKEIE"
     aSDomain        1101..1301
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg60_1_PCP.1"
                     /evalue="1.20E-27"
                     /label="ctg60_1_PCP.1"
                     /locus_tag="ctg60_1"
                     /protein_end="433"
                     /protein_start="366"
                     /score="87.8"
                     /tool="antismash"
                     /translation="EQILADIWKEVLGAEKIGTADSFFELGGDSIKALQVSARLHRIGK
                     QMAVKDLFSHPTIQELAAYIRD"
     aSDomain        1332..2267
                     /aSDomain="Epimerization"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg60_1_Epimerization.1"
                     /evalue="3.30E-156"
                     /label="ctg60_1_Epimerization.1"
                     /locus_tag="ctg60_1"
                     /protein_end="755"
                     /protein_start="443"
                     /score="513.0"
                     /tool="antismash"
                     /translation="EGDVQWSPVQKWFLSQDIKEKHHFNQSVMLHRSTSVQEDALRKTL
                     KAITCHHDALRMVFTQNEQGKWDQYNRPLSHSDDALYGLQMIDLSAPDGTDGNRAYEPI
                     IKRHVLDIQQKMDLKNGPLLQAGLFHTIDGDFLFLSAHHLVVDGISWRVLLEDLALGYR
                     QAAGGEDIKLPPKTSSFKAYAKKLSDYAESQQLMKQLKYWREAEEYQTEALPFDQIDGT
                     RAHEGQRSTISFTLNEKETAALLKDANSAYNTDTQDMLLASVILALRHWTNQSAFKLSL
                     EGHGREDVLEGIDVSRTIGWFTAIYPLLIKL"
     CDS_motif       1482..1523
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg60_1_0004"
                     /evalue="7.60E-04"
                     /label="Cy2"
                     /locus_tag="ctg60_1"
                     /protein_end="507"
                     /protein_start="493"
                     /score="12.2"
                     /tool="antismash"
                     /translation="HHDALRMVFTQNEQ"
     CDS_motif       1740..1805
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg60_1_0005"
                     /evalue="1.60E-11"
                     /label="NRPS-E2"
                     /locus_tag="ctg60_1"
                     /protein_end="601"
                     /protein_start="579"
                     /score="36.3"
                     /tool="antismash"
                     /translation="LFLSAHHLVVDGISWRVLLEDL"
     CDS_motif       2211..2258
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg60_1_0006"
                     /evalue="3.60E-08"
                     /label="NRPS-E5"
                     /locus_tag="ctg60_1"
                     /protein_end="752"
                     /protein_start="736"
                     /score="25.5"
                     /tool="antismash"
                     /translation="DVSRTIGWFTAIYPLL"
     aSDomain        2304..2771
                     /aSDomain="TIGR01720"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg60_1_TIGR01720.1"
                     /evalue="1.30E-45"
                     /label="ctg60_1_TIGR01720.1"
                     /locus_tag="ctg60_1"
                     /protein_end="923"
                     /protein_start="767"
                     /score="146.8"
                     /tool="antismash"
                     /translation="HVLKTTKDTLRRVPDKGFGYGVIKYLTPPGKKDIDFTGAPEISFN
                     YLGQFESGRTAEVPEEDAFSFSPLGAGGDISTTWNREQSLDISAIAAEGKLTVNMTYDN
                     ARFQRKTIEQLSETCRQFLLQLIEHCQNKSETEKTISDYDDQELTEDALQEI"
     CDS_motif       2319..2381
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg60_1_0007"
                     /evalue="7.10E-10"
                     /label="NRPS-E6"
                     /locus_tag="ctg60_1"
                     /protein_end="793"
                     /protein_start="772"
                     /score="31.0"
                     /tool="antismash"
                     /translation="TKDTLRRVPDKGFGYGVIKYL"
     CDS_motif       2421..2450
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg60_1_0008"
                     /evalue="2.80E-03"
                     /label="NRPS-E7"
                     /locus_tag="ctg60_1"
                     /protein_end="816"
                     /protein_start="806"
                     /score="10.2"
                     /tool="antismash"
                     /translation="PEISFNYLGQ"
     aSDomain        2824..2910
                     /aSDomain="NRPS-COM_Nterm"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg60_2_NRPS-COM_Nterm.1"
                     /evalue="2.20E-17"
                     /label="ctg60_2_NRPS-COM_Nterm.1"
                     /locus_tag="ctg60_2"
                     /protein_end="29"
                     /protein_start="0"
                     /score="53.9"
                     /tool="antismash"
                     /translation="MDNIKKIKNIYPLSHMQEGMLFHSFLRKE"
     CDS             2824..3036
                     /NRPS_PKS="Domain: NRPS-COM_Nterm (0-29). E-value: 2.2e-17.
                     Score: 53.9. Matches aSDomain:
                     nrpspksdomains_ctg60_2_NRPS-COM_Nterm.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Condensation"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg60_2"
                     /sec_met_domain="Condensation (E-value: 6.3e-20, bitscore:
                     58.5, seeds: 42, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDNIKKIKNIYPLSHMQEGMLFHSFLRKEEGAYVEQSLFAIKGSL
                     SYEWFQRSIQAIIDRHDIFRTVFLPR"
     CDS_motif       2854..2895
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg60_2_0001"
                     /evalue="6.90E-07"
                     /label="C1_DCL_004-017"
                     /locus_tag="ctg60_2"
                     /protein_end="24"
                     /protein_start="10"
                     /score="20.5"
                     /tool="antismash"
                     /translation="YPLSHMQEGMLFHS"
     CDS_motif       2914..3030
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg60_2_0002"
                     /evalue="4.70E-17"
                     /label="C2_DCL_024-062"
                     /locus_tag="ctg60_2"
                     /protein_end="69"
                     /protein_start="30"
                     /score="54.3"
                     /tool="antismash"
                     /translation="GAYVEQSLFAIKGSLSYEWFQRSIQAIIDRHDIFRTVFL"
ORIGIN
        1 atcatttggc ttatatcatt tatacctctg gaacgacggg ccgtccaaaa ggggtaatgg
       61 tcgagcataa aggtattgcc aacactcttc agtggcggcg aaacgcttat gcattcaacg
      121 agacagatac cattctgcag ctcttttctt tctcatttga cggctttata actagtatgt
      181 ttacaccgct tttgtcaggt gcaaaagccg ttttgcttca tgaagaggaa gcgaaggata
      241 ttctggccat taagcatcag ctgtctcgtc agcggattac acatatgatt attgtgcctg
      301 ttttatatcg agcgcttttg gacgtagtgc agccggaaga tgtaaagacg cttagagtcg
      361 tcacactggc gggagaagcg gctgaccgcg aattgatcga ccgcagctta gctatatgtc
      421 cgcataccga actcgccaac gaatatggac cgacagaaaa cagcgtggcg actaccgtca
      481 tgagacatat ggaaaagcag gcatacgtaa gcatcggcca gccgattgac gggactcaag
      541 tgctgatttt aaatagcaat catcagcttc agccaatcgg tgttgcggga gagctttgta
      601 tagcaggaac agggcttgca agagggtacg tcaatcttcc agaactgaca gagagagcat
      661 tcacgcagaa tccatttaaa cccgaaacac gaatgtaccg aacaggagac gccgccagat
      721 ggatggccga cggtacactc gaatatctcg gaagaatcga tgatcaagtc aaaatcagag
      781 gataccgtgt agaaacgaaa gaaattgaat cggtcatccg gtgtataaat ggtgtaaaag
      841 acgccgcagt agttgctcat gtaacagcgt caggacaaac cgaattaagt gcttatgtgg
      901 tgacaaaacc agagttgagc acaaatgctg tacgctcaga attacaaaac aagctgccgg
      961 tgtttatgca ccctgcgttt attgaaaaac tggactcact tccattgtca ccaaacggca
     1021 agctggatcg cggagcactt ccaaaacctg tatacaacca cgaaggtgaa cgtccattcc
     1081 tcccgccagc cagcaaaatg gaacaaatac tggcagatat ttggaaagaa gtactggggg
     1141 cagaaaagat cggaacagct gattcgttct ttgagcttgg cggagattcg atcaaagcgt
     1201 tacaggtatc tgcgcggctt caccggatag gcaagcaaat ggcagtgaaa gatttgttta
     1261 gccatccgac cattcaagaa ttggcagctt atatccgtga ttcagataca agttccagcc
     1321 aagctgcggt tgagggagac gtacagtggt cgcctgttca aaaatggttc ctttctcaag
     1381 atataaaaga aaaacaccat tttaatcagt ccgtaatgct gcatcgaagc acctctgtac
     1441 aagaagacgc actgcgcaaa acgttaaaag caataacgtg tcatcatgat gcgctgcgaa
     1501 tggtgtttac acagaatgaa caaggaaagt gggatcaata taatcggcct ctcagtcatt
     1561 cggacgacgc gttgtacggc cttcagatga ttgatttatc agctccggac ggcactgatg
     1621 gaaatagagc gtatgagcct attatcaaac gtcatgtact tgatattcag cagaaaatgg
     1681 atttgaagaa tggtccgctg ctgcaagccg gtcttttcca cacaattgac ggtgatttct
     1741 tatttttatc tgctcatcac ctcgtcgttg acggcatttc atggcgggtt ctgcttgaag
     1801 atttggcttt agggtatcgc caagctgcag gcggggagga tatcaaactg ccgcctaaaa
     1861 caagctcgtt taaagcgtat gcgaaaaagc tctctgacta cgctgaaagc cagcagctaa
     1921 tgaaacagct caagtattgg cgcgaagccg aagagtatca aacagaggca ttgccttttg
     1981 atcaaatcga tggaactaga gcacacgagg gacaacggtc cacgatttca tttaccttaa
     2041 acgagaaaga gacagcagca ctcttaaaag acgccaacag cgcatataac actgatacgc
     2101 aggacatgct gctcgcttct gtcattcttg cgctgcgcca ttggaccaat caatccgcct
     2161 tcaaactatc attagagggc cacgggcgag aggatgtatt agaaggaata gatgtgagcc
     2221 ggacgattgg atggtttacc gccatttatc cgttattgat taaactgaac gcagacttgc
     2281 cagattcgga agaaggcatg gttcatgtgc taaaaacaac aaaagataca ctgagacgtg
     2341 tacctgacaa aggattcggc tacggtgtca tcaaatattt gactccgcct ggcaaaaaag
     2401 acatcgattt cacaggtgca ccagaaatca gctttaatta tcttggtcaa tttgaaagcg
     2461 gccgcacagc tgaagtacct gaggaggacg ccttctcatt ctctccgctg ggtgccggag
     2521 gtgatatcag cacaacatgg aaccgtgaac agtcgctgga tatcagcgca atcgctgcag
     2581 aaggaaaatt gactgtcaat atgacttatg acaatgcccg ctttcagcgc aaaaccatcg
     2641 aacagcttag cgaaacatgc cgtcaatttt tattacagct gatcgaacac tgccagaaca
     2701 aaagcgaaac agaaaagacg atcagcgatt atgatgatca agaactgacc gaggacgcgc
     2761 tgcaagagat tgctgatatg ctcagttttc actaatgaaa ccgtgaagaa aggtgcagac
     2821 actatggata acatcaaaaa aatcaagaac atttatcctc tgagtcatat gcaggaggga
     2881 atgctgtttc attccttcct ccgtaaagag gagggggcat acgttgagca gtcgctcttc
     2941 gccattaaag gaagcctcag ctatgaatgg tttcagcgca gcattcaagc cattatcgac
     3001 cgccatgata ttttcagaac cgtgtttttg ccgagg
//
