LOCUS       c00025_gnlPro..        15945 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|ICEEANDE_32.
ACCESSION   c00025_gnlPro..
VERSION     c00025_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2025-04-29 03:04:59
            Original ID  :: gnl|Prokka|ICEEANDE_32
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15945
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15945
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2732:5945]"
                     /cutoff="10000"
                     /detection_rule="(Amidinotransf and OTCace and OTCace_N and
                     AA_kinase)"
                     /neighbourhood="10000"
                     /product="Arginine2_Hcarbonate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2733..5945
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Amidinotransf and OTCace and OTCace_N and
                     AA_kinase)"
                     /neighbourhood="10000"
                     /product="Arginine2_Hcarbonate"
                     /protocluster_number="1"
     cand_cluster    1..15945
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Amidinotransf and OTCace and OTCace_N
                     and AA_kinase)"
                     /kind="single"
                     /product="Arginine2_Hcarbonate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15945
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Arginine2_Hcarbonate"
                     /region_number="1"
                     /rules="(Amidinotransf and OTCace and OTCace_N and
                     AA_kinase)"
                     /tool="gutsmash"
     CDS             complement(108..713)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg25_1"
                     /sec_met_domain="LysR_substrate (E-value: 9e-19, bitscore:
                     58.2, seeds: 361, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKLRIAYFNQLGRRQLDRIVDQFKQKHSDVEIELIGMGHDEAFD
                     KLAKNEVDLAISDLRDDQLDFKKEILGQEAVMAILQKGSYPSGVQMINKDDLADLTCFI
                     VAKPEEEAAELHLFKDIYQIRSPFIASNSVEEAALLVASGSGYFLMNEATASLISNDTL
                     QRLFLLSNGQQMWQKIAAFYTNEDAVIKDFILLAKKVY"
     CDS             complement(716..877)
                     /locus_tag="ctg25_2"
                     /transl_table=11
                     /translation="MSKQKKVRLLKFLSVVVSGINVVISLLIMFNKYQIRKDKKQISDE
                     GHAPLDEN"
     CDS             complement(893..2059)
                     /locus_tag="ctg25_3"
                     /transl_table=11
                     /translation="MKLKKNQDNLKQIASLIEYAFLKDSDLTTDSNFMPRYDHSDGYGY
                     FDQEKLTSYMMVNKFKAEIFGHHVPLAGIGYVASYPEYRGRGHISKLMKEILFDLHDQK
                     IPVANLAPFSEKFYRHYGFSNSIYQKEYRFSGAALASFRLPRKGKIIRGKWNDLIVQNG
                     VIQLYERQLHTDDERNTIIREAWWWNRLDDYYHHREIAVYFDEAGRPMSYLIYRIIDNC
                     FMADELYSITPQGLLSILGFMAAHIGSIKEFCMTLHEKSLLAELFPEQNELDIQLHPYM
                     MSRIIDFQKVLACMRPLQEGTFNIEVNYDDQCPWNIGVWQLTNYDHQVKCERKEDELVD
                     FSGPITTWTQILLGRLTMESAIKLGLITDYRIKKLDFVKGKVSFYDYF"
     CDS             complement(2180..2716)
                     /locus_tag="ctg25_4"
                     /transl_table=11
                     /translation="MNIFQEGNPQNIAQVLAGKDYRVALQQAIFKKYPDATLVDINLNI
                     PGPIKNNRYLIKLFDYGIKQLEEIWQNNGYDYKLVKALNNDAGCENFYVLRESSKVVKL
                     STILFEENNKIGRLFDADVLIKGKTALSRQELEYSSRRCYLCNRPAKECARSRRHSVEE
                     MQRYISSLYAKYVNN"
     CDS             complement(2733..3074)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Arginine2_Hcarbonate: AA_kinase"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg25_5"
                     /sec_met_domain="AA_kinase (E-value: 3.3e-19, bitscore:
                     60.0, seeds: 128, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VKDDSLQGVAGVIDKDFSAAKLAEDIQADELVILTTVDNAYVNYN
                     QPDQAPIGKIKIDQLKKYLEAGQFAAGSMKPKIEAVIDFVEKTGKTAIITSLRNASKLD
                     DGVGTIVYN"
     CDS             complement(3243..3665)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Arginine2_Hcarbonate: AA_kinase"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg25_6"
                     /sec_met_domain="AA_kinase (E-value: 4.4e-13, bitscore:
                     39.9, seeds: 128, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRIVVAFGGNAIEAGDNSAAAQEKQVKKTMKVVAKMIENGDQVA
                     IVHGNGPQVGNLLLQQYKGSSKDNLAMPLDTVVSMTQGSIGYWMQKALDDQFKHTNYPH
                     QAVALITQIIVNANDPTFKNPTKLIGPFYTFNEMQR"
     CDS             complement(3860..4468)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Arginine2_Hcarbonate: OTCace"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Arginine2_Hcarbonate: OTCace_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg25_7"
                     /sec_met_domain="OTCace (E-value: 1.9e-37, bitscore: 119.4,
                     seeds: 50, tool: rule-based-clusters)"
                     /sec_met_domain="OTCace_N (E-value: 1.3e-24, bitscore:
                     77.5, seeds: 1463, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGAGEIHLGKKESIEDTAKVLGSMFDDIEYRGFAQKDVEDLAKYS
                     GVPVWNGLTDKWHPTQMLADFMTIKEKFGHLKVLTLAYVGDGRDNVADSLLVAGSMLGV
                     NVHIVTPKPLFTHPDVQKIAEGFAKDSGSRNLITDDIEQGVKGANIIYTDVWVSMGEND
                     WSERIKLLKPYTVTMNMMYMTGTPDDQLIFMHCLPAFHD"
     CDS             complement(4567..4704)
                     /locus_tag="ctg25_8"
                     /transl_table=11
                     /translation="MKYLQNVFQGRSLLKCKDYTPTELNYLIDFALHLKELKKIFRMNI
                     "
     CDS             complement(4716..4988)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Arginine2_Hcarbonate: Amidinotransf"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg25_9"
                     /sec_met_domain="Amidinotransf (E-value: 7.6e-31, bitscore:
                     97.9, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VLKNYLHLSEIDLIPTGGGDAIAAPREQWNDGSNTLAIAPGEVVT
                     YDRNYVSNDLLRKHGILVHEIHSSELSRGRGGPRCMSCPLVREDL"
     CDS             complement(5218..5628)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Arginine2_Hcarbonate: Amidinotransf"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg25_10"
                     /sec_met_domain="Amidinotransf (E-value: 2.6e-28, bitscore:
                     89.6, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDYLIAMPVNEMVKQIIAGIRKNEMQNATPSLADLAENPDYPFYL
                     DPMPNVYFTRDQQATIGNGMTINRMTFRARRRESLFMETVLKHHPDFKNANIPIWCDRY
                     THGRLEGGDELILNNHVFSNRYFSKNFRCRNH"
     CDS             complement(5760..5945)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Arginine2_Hcarbonate: Amidinotransf"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg25_11"
                     /sec_met_domain="Amidinotransf (E-value: 1.9e-11, bitscore:
                     34.2, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDLIHVYSEIGKLETVMLHRPGRELENLSPDILNRMLIDDIPYL
                     KIAQKEHDYFAHTLEK"
     CDS             complement(6018..6872)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HTH_1"
                     /gene_functions="regulatory (smcogs) SMCOG1012:Bacterial
                     regulatory helix-turn-helix protein, lysR family (Score:
                     72.5; E-value: 6.7e-23)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg25_12"
                     /sec_met_domain="LysR_substrate (E-value: 2.1e-28,
                     bitscore: 89.7, seeds: 361, tool: rule-based-clusters)"
                     /sec_met_domain="HTH_1 (E-value: 2.5e-23, bitscore: 72.5,
                     seeds: 1330, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIKQLRYFLVVAKEKQITSAAKRLYIAQPPLSYQLKQLEIELGA
                     QLFKRTAHGIELTDAGQILQSYASEILSLSESVKNQVHKTVSGELGTIAIGMASSSTGL
                     IPMKSFQDLTKFYPEINFDIYEDNTFGIIDKLEKKTIDLGIVRTPYNRNGLNAKTLTTE
                     RMMAVTVDPKFKDKTGLRIKDLNEQPLIIYRRFEEIFNQTFAHHGIKPFYAVKCDDSRT
                     AITWAKRKMGIALVPESIASTYAPDDLIPIKYSNWITHLQLVRRKDQKVTPLMKRIIDS
                     LSR"
     CDS             7001..9274
                     /locus_tag="ctg25_13"
                     /transl_table=11
                     /translation="MSEKFHGLTQAEADKRLKEDGLNEAPEPEYNFFKEFLSKLWNLSA
                     WVLEGALILECILGKWIQSLFVLLMLLFAAFNGASKKKQSRRVLNTISHKLTPKVAVER
                     DGKWIKIDSKQLVRGDLISLQRGDVLAADVKMVSGKIACDESSITGESKPVKKNIDDTA
                     YAGTTVVEGDGLAIVTATGKDSRSGKTINLINNSAAPGHLQQLLTKIIYYLCLLDGVLT
                     LVIIIASFFKGGNFDTFINMLPFLAMMFIASIPVAMPSTFALSNSFEATRLSKEGVLTA
                     DLTGIQDAANLNLLLLDKTGTITENKTAVASWSNLSDLPDKDVLALVGSATDKRNAGII
                     DIAIDEYLKENDIPVMDVEHFTPFTSDTGYSMAEVDGHNVKLGSFKQLSLIDKNANEAV
                     EGINFKAGRSVAVLIDDKLAGVFILQDKVRKDSKAALAELKKRGVRPIMLTGDNQRTAA
                     AVAEQVDLTGNVISIHDFDESTDIDELAGIADVLPEDKLKMVKFFQEKGYIVGMTGDGV
                     NDSPALKQAEVGIAVSNAADVAKRSSKMVLLDDGLSSIVKILDAGHRVYQRMTTWSLAK
                     LARTAELTMLLTFGYLFFNYIPMALNAMVIYTIMNNMVTMMIGTDRTHITYKPENWNMA
                     RLAKIAFSLAAGWTVIGIAFFSYLNMHGWSHNSISTMVYVYLVLSAMLIVLITRTRKYF
                     WQDYPSKLVGIVQIADVALTFILALCGLAMAQISWQNLLITVVVALIAAIIIDLIYQPV
                     MKNR"
     CDS             complement(9343..9840)
                     /locus_tag="ctg25_14"
                     /transl_table=11
                     /translation="MRKQIISAAGIMLAVIGLGAATTQSVDAVVTNPVRQGKRLNLTRN
                     ATVYNRHGVKVGHLRKGKLYKVRAIKVINGNTYVKIRKNRFVKEEAFLPYMKTTVKVVN
                     RIKKHSFVYDENGEKIPGKFLKRGAKVNYLGHKEINEKPFIKIADGEYVKALNALTTVT
                     NY"
     CDS             10102..10668
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PLDc_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg25_15"
                     /sec_met_domain="PLDc_2 (E-value: 2e-09, bitscore: 28.1,
                     seeds: 83, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLVLTVLPGIGFILYLFFGRQLSHDEIFAIQEEQKKVQRHYLAEQ
                     RDMLKEHDLLPEKERLPRVRMLSELNLNNDDAILTFDNQVKVFISGPELFDQMITDIKN
                     AKKSVSLELYTFYSNQLGHRVLKALEEAAANGAKVRVIYDTSGSRGTKPSFFDHLRAAK
                     LSHLFPLQKSTGLLPHDSITTYIEN"
     CDS             10906..11463
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PLDc_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg25_16"
                     /sec_met_domain="PLDc_2 (E-value: 4.4e-28, bitscore: 88.4,
                     seeds: 83, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIIKMSLCKLFPQDLIINITASDEAEGIIAGAKKYIYIQTPYLIP
                     EESILEALIIAANSGIDVRIMVPCMPDHPFVYRATEYYAKYLVAHGVKVYKYNDGFIHA
                     KTMVSGSNISSVGSANQDFRSYTLNFEVNSFNYNPALTQELKKIFEKDLDKCTLLTNDY
                     FAQQSSWLKFKQYFSRLLSPIF"
     CDS             11594..12388
                     /locus_tag="ctg25_17"
                     /transl_table=11
                     /translation="LANRVKIGVLNLMHDKLDTQQRFARVLPDADLTFFYPRMHYQNRP
                     VPPEVAKTSQPLDLNQIKEFDGFIITGAPLDHLDFDQVTYIEEVRCLLQLLDKYKLQQL
                     YFCWGAMAALDYFYNIQKRILSKKIFGVFPHLIIEPHPLLNGLSKGFIAPHARYAEMDK
                     TQIMQDPRLTINSVDDNGHLFMVSSLEKPEQNFIFSHIEYGRKGLKKEYEREIAAHPER
                     HYKKPENYSLSNLLFQWKDTQKTFFNNWLTQVKKSKLVLLDK"
     CDS             12404..13333
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg25_18"
                     /sec_met_domain="PALP (E-value: 5.9e-69, bitscore: 223.2,
                     seeds: 146, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTIYNSVTELIGNTPLLKLNRVVPDDAADVYVKLEFENPAGSIK
                     DRIALAMIEKAEREGNLKPGGTIVEPTSGNTGIGLAMVAAAKDYHIIIVMPETMSVERR
                     KLMKGYGAELILTPGADGMKGSIAKAEELVKEKGYFMPMQFENTENPNIHELTTGPEII
                     AAMNGIGKSVDAFVAGVGTGGTLSGIGHALRRENPSTKIFALEPTESPLLKDGKTGKHG
                     IQGIAAGFIPKNLDKDIYDDIITVSTDEAMATAREVAKNEGFLPGISAGANIHGAIEIA
                     KKLGKGHAVVTVVPDGGDRYLSTALFNA"
     CDS             complement(13477..14004)
                     /locus_tag="ctg25_19"
                     /transl_table=11
                     /translation="MAIDFSKYIASVKDFPNKGIVFRDITPILQDGELYRIATHELAEY
                     AKSRKADVIVGPEARGFIVGCPVATELGLGFVPARKPHKLPREVERASYDLEYGSNSLE
                     MHKDAIKPGQRVVLCDDLMATAGTLRASKELIENLGGKLVGAAFYIELPDLKGREKLPD
                     VDIYSLVQYHGA"
ORIGIN
        1 tctatcaaac aggtccgaat ggacttttta ttttttatca agtgttcaac ttaattttac
       61 aatcagcgca tttttatttt tacagtattt tgctgttcca agatagatta atatactttt
      121 ttagctaaca aaataaaatc tttaattact gcatcttcat tggtataaaa agctgcaatc
      181 ttttgccaca tttgttgtcc attagacaat aaaaacaatc gttgtaaagt atcattacta
      241 attaaactgg cggttgcttc attcattaaa aaatatcctg atccagaagc tactaacaat
      301 gctgcctctt ctacggaatt tgaagcaatg aatgggcttc taatctgata aatatcttta
      361 aataaatgga gttctgcagc ctcttcttca ggcttagcta caataaaaca ggttaaatca
      421 gctagatcat ctttattgat catctgaaca ccgctaggat aactaccctt ttgcaaaata
      481 gccattactg cttcctgacc taagatttct ttcttaaaat cgagctgatc atcgcgcaaa
      541 tcactaatcg ctaaatcaac ttcatttttg gctaatttat caaaagcttc atcgtgtccc
      601 attccaatta attcaatttc tacatcagaa tgtttttgct taaattggtc tacaattcga
      661 tctaattgtc ttctaccaag ttggttaaag tatgctattc tcaatttttt catagttaat
      721 tttcatccaa tggggcatga ccttcatctg atatttgttt tttatctttt ctaatttgat
      781 atttgttgaa cataatcaat agcgaaataa ccacatttat tccactaact accacgctta
      841 aaaattttag taatctaact ttcttttgct tactcatttt ggataccttc ttctaaaaat
      901 aatcataaaa tgagacttta ccttttacaa agtccaactt tttaattcga taatctgtga
      961 tcaaaccaag tttaattgcg gattccatag ttaaacgtcc taataagatt tgagtccatg
     1021 ttgtaattgg accagagaaa tcaactagtt catcttcttt tcgttcacac ttaacttggt
     1081 gatcataatt agttaattgc caaacgccaa tattccatgg acactgatca tcataattaa
     1141 cttcgatgtt aaaagtaccc tcttgcaatg ggcgcatgca tgccaagact ttttggaaat
     1201 caataattct actcatcata tatggatgaa gttgaatatc caattcattt tgctctggaa
     1261 aaagttcagc caataaagac ttctcatgca atgtcataca aaactcttta attgacccta
     1321 tatgagctgc cataaagcct aatatgctta ataatccttg aggcgtaatt gaatataatt
     1381 catcagccat aaaacagtta tcaattatgc gataaatcaa gtagctcatc ggccgaccag
     1441 cttcatcgaa gtaaacagca atctctcgat gatgataata atcatctaat ctattccacc
     1501 accaagcttc tctgatgatc gtatttcttt catcgtcagt atgcaactga cgttcatata
     1561 attgaatcac accattttga acaatcaaat cattccattt tccacgaatt atcttacctt
     1621 tgcgtggtaa tctgaaagaa gcaagtgcag cccccgaaaa gcgatattct ttttggtaaa
     1681 tactattgct aaaaccataa tgacgataaa atttttctga aaatggagct agatttgcaa
     1741 ctgggatttt ttgatcatgc aaatcaaaaa gaatttcttt cattaattta gatatatgtc
     1801 cacgtcctct gtattcagga tatgatgcca cataaccaat acctgccagt ggaacatgat
     1861 gaccaaatat ctcagcttta aacttattga ccatcatata actggtcaat ttttcttgat
     1921 caaaatatcc atatccatca ctatgatcat atcggggcat aaagttacta tctgtagtca
     1981 aatcagaatc ttttaaaaaa gcatattcaa tcaatgaagc aatttgtttt aaattgtctt
     2041 ggtttttctt taatttcata gttttcctta caatatatat tcataacttt acttatattt
     2101 tagaacattt tatgtatttt tcgttagctt tttttaagat ttaaatgaaa aaacgggatg
     2161 attagcctcc catcccgttt taattattta catacttcgc atataaacta gaaatgtatc
     2221 tttgcatctc ttctactgag tgtcgccgtg atcgagcaca ctctttagca gggcgattgc
     2281 ataaatagca gcggcgacta gagtattcaa gctcttggcg tgaaagtgca gttttccctt
     2341 taattaatac atcggcatca aataatcgtc ctattttatt attttcttca aataaaattg
     2401 tagataattt aactactttg ctagattctc gcaaaacata gaaattttca catccagcat
     2461 cattatttaa tgcttttact aatttatagt catatccatt attctgccat atttcttcta
     2521 attgtttaat tccgtaatca aataatttga ttaaatatcg attattttta attggccccg
     2581 ggatatttaa gtttatatca accaaagtcg catcaggata ctttttaaaa atagcttgct
     2641 gcaaagctac acgataatct tttccagcta atacctgagc aatattttgc ggatttcctt
     2701 cttgaaaaat gttcatttat atctcaccgc agttaattat aaacaattgt acctactcca
     2761 tcatcaagtt tacttgcatt tcttaaagaa gtaataattg cagtctttcc tgttttctct
     2821 acgaaatcaa tgacagcttc aatttttggc ttcatgctgc ctgcagcaaa ttggccagct
     2881 tctagatact tctttaattg atcaatcttt atttttccaa taggagcttg atcaggttga
     2941 ttatagttca cgtaggcatt gtcaacagta gttagaataa ctaattcatc tgcttgaata
     3001 tcttcagcta gttttgcggc actgaagtct ttatcaatta ctcctgctac gccttgcaaa
     3061 ctatcgtctt tcactacaac aggaattcca tcacctccgg cagcaatagg aacaaacttg
     3121 ctctttagta aagtgtcaat gcctggtgca ttaataattt taacgggctt tggagaagaa
     3181 actacttgac gatagcctcg acctgtatct tgcttataag tatattcagg atgatagatt
     3241 ttttacctct gcatttcgtt aaatgtataa aatgggccaa ttagtttagt tggattctta
     3301 aaagttggat cattcgcatt aactattatc tgagtaatta aagcaacagc ttgatgtgga
     3361 taatttgtat gtttaaattg atcgtctaag gccttttgca tccaatagcc gatactgcct
     3421 tgagtcattg atactactgt atcaagcggc atagcgagat tatctttact tgaacctttg
     3481 tattgttgca aaagcaaatt accaacctgc gggccattac catgaacaat cgctacctga
     3541 tcaccatttt caatcatttt agcaacaacc ttcattgtct ttttaacctg cttttcttgg
     3601 gcagctgcac tattatcacc tgcttcaata gcattgccac cgaaagctac aactattctt
     3661 ttcatcttta tttacttcct tcatcaactg acggaataaa caaattgccc aaagtagcgg
     3721 ccattattgc tttgatagaa tgcaatctat tttccgcttc agtaaattgc caagcgtatt
     3781 gagagttaaa gacttcatct gtaacttcca cttcacttag accatatttt tcataaattt
     3841 ctttgccaac tttagcagtt caatcatgaa acgcaggcaa acagtgcata aagattagtt
     3901 gatcatccgg ggtgcctgtc atatacatca tattcattgt aaccgtgtaa ggctttaaca
     3961 atttgattct ctcactccag tcattttcac ccattgatac ccagacatca gtataaataa
     4021 tatttgcacc tttaacgcct tgttcaatgt catcagtaat caaatttctt gatccagaat
     4081 ctttggcaaa accttctgca attttttgta catcagggtg agtgaataaa ggctttggcg
     4141 taactatgtg tacattaact ccaagcatgc tgccagccac taaaagactg tcggcaacat
     4201 tatcacgtcc atcgcctaca taagctaaag taagtacctt taaatgtcca aacttttctt
     4261 taatagtcat aaagtcagcc aacatttggg tcggatgcca tttatctgtt aaaccattcc
     4321 aaacagggac accagaatat ttagccaaat cttctacatc tttttgagca aaaccgcgat
     4381 attcaatgtc atcaaacata ctgcccaaaa ccttggcagt atcttcaata ctttcctttt
     4441 tacctaaatg aatttcacca gcacccatat attcaggatt tgcgcctaaa tcattgcatg
     4501 caactacaaa ggctgaacgt gttcttgttg aagatttttc aaataaaaga gctatattct
     4561 ttccttttaa atattcatgc ggaatatttt ctttagttcc ttcaaatgaa gtgcaaaatc
     4621 aattagatag ttaagctccg ttggagtata gtctttgcat tttaataaac ttctgccttg
     4681 aaacacattt tgtaaatatt tcattttgac gcctcttaca aatcttcacg aacaagtgga
     4741 catgacatac atcttggacc tccacggcca cgagaaagct cacttgaatg aatttcatga
     4801 actaaaatgc catgctttct taacaaatca tttgatacat aattacgatc atatgtaacg
     4861 acttcacctg gcgcaatagc caaagtattc gagccatcat tccactgctc tcttggggct
     4921 gcaattgcat ccccacctcc ggttggaatt aggtcaatct ccgataagtg caaataattc
     4981 tttaacactt tgatcaaatc agtttctggg gtaattttaa tctcaccatg atcatcttgc
     5041 tctaaaacat aaatatcaat ctttcctgat ttgtctaaaa taaaaggatg aacagtacac
     5101 taatcataat taatcattgt aaagactgta tccagatgca tcatggcatg attatgtggt
     5161 attttaattg ctaaaattgt gtcataacta gaatgaccaa acaggctatg agcaaggtca
     5221 gtgattgcgg cagcggaagt tctttgagaa ataccgattg ctaaaaacat gattgtttaa
     5281 aatcagctca tcgccacctt ctaaacgtcc atgagtgtaa cgatcacacc aaataggaat
     5341 attggcattt ttaaagtcgg gatgatgctt taaaacggtt tccataaata atgactcacg
     5401 tcttctagct ctaaacgtca ttctattaat agtcatgcca ttaccaatag ttgcttgttg
     5461 atcacgagta aaatacacat ttggcattgg atccaaataa aatggataat ctggattttc
     5521 agctagatcg gctaatgaag gagttgcatt ttgcatttca ttttttctaa taccagcaat
     5581 tatttgctta accatttcat ttactggcat tgctattaaa tagtccatca gtaattgatg
     5641 taatggatct tcttttttat attggattct tctaataatt gatctacaaa ttttgtacgg
     5701 acatcttcat tagtcaaaga gtgagctaat aaatcttcta aataaacgac atgaactccc
     5761 tatttttcca aagtgtgggc aaaatagtca tgctcttttt gagctatttt taaatatgga
     5821 atatcgtcaa ttaacattcg atttaagata tccggtgaaa gattttctaa ttctcttccc
     5881 ggtcgatgca gcataactgt ttctaatttg ccaatttcgg aataaacatg aattaagtca
     5941 gtcattatag cgcctcctaa ttcaaattat gtatccgctt acaataatta aggatcaatt
     6001 aggtagaagt tacaatctta acggcttagt gaatctatta ttcttttcat taaaggcgtc
     6061 accttttgat ccttgcgcct cactaattgc aaatgcgtaa tccaattact atatttaata
     6121 ggaataagat catcaggtgc atacgtagaa gcaatagatt caggaacaag agcaatcccc
     6181 atttttctct tcgcccaagt aatcgctgtt ctagaatcat cacatttaac agcataaaac
     6241 ggcttaatcc catgatgagc aaaagtctgg ttaaaaattt cttcaaatct tcgataaata
     6301 atgaggggct gctcatttag atctttaatc cttaatcccg tcttatcctt aaatttggga
     6361 tcaacagtaa ctgccatcat tctttcagta gttaaagttt ttgcatttaa gccattacga
     6421 ttataaggcg tacgcacaat tcctaaatcg attgtcttct tttccaattt atcgataatg
     6481 ccaaaggtat tatcttcata aatatcaaag ttgatttccg gataaaactt agttaaatct
     6541 tgaaaacttt tcataggaat tagtccagtt gatgatgaag ccatgcctat tgcaatcgtg
     6601 cctagttcac ctgaaacagt tttatgaacc tgatttttca cgctttctga taaagagaga
     6661 atttcactag catagctctg caaaatttgt ccagcatctg ttaattcaat tccatgagca
     6721 gtacgcttaa ataattgtgc tcctagttct atttctagtt gctttaattg ataactcagc
     6781 ggcggttgtg caatgtatag tcttttagct gctgaagtga tttgcttttc tttggctact
     6841 actaaaaagt agcgtaattg tttaatattc attaataatc tatctttttt attttagttg
     6901 tatctcttat taaaaatttc tatatcttat attttaattt agtattttca ttcaaacaac
     6961 atatgtgcta ctttattaag gtagatttgg agggaataaa atgtctgaaa aatttcatgg
     7021 cttaactcaa gccgaagcag ataagagact taaggaagat gggttaaacg aagcacctga
     7081 acccgaatac aactttttta aggaatttct atcaaaatta tggaatcttt ctgcctgggt
     7141 tctagaaggt gccttaatcc tcgaatgtat cttaggcaaa tggattcaat ctttgttcgt
     7201 cttgttgatg cttctttttg cggcttttaa cggtgcatcc aagaagaaac agtcacggcg
     7261 ggtattaaat accatttcac ataagctaac ccctaaggtg gctgtagaac gcgatggtaa
     7321 gtggatcaaa attgactcta agcaattagt tagaggcgac ttaatctcac ttcaacgtgg
     7381 agatgtactt gcagccgatg taaaaatggt tagcggtaag atcgcctgtg atgaaagctc
     7441 aattaccggt gaatctaagc ccgttaaaaa gaacattgat gacacagctt atgctggtac
     7501 tactgttgtt gaaggcgatg gattagcaat tgttactgca actggtaaag attcaagaag
     7561 tggtaagacc attaacttga tcaacaattc agctgcacct ggtcacttgc aacaactttt
     7621 aactaagatt atttactacc tttgcctact tgacggtgta cttaccttag ttattatcat
     7681 tgcttcattc tttaagggtg gtaattttga tacgtttatc aacatgttgc cattcttagc
     7741 catgatgttc atcgcttcaa ttccggttgc gatgccgtca acctttgcat tgtccaattc
     7801 atttgaagca acccgtttaa gtaaagaagg cgtcttaaca gctgatttaa ctggtatcca
     7861 agatgcagct aacttaaact tgcttttact tgataagacg ggaacaatca ctgaaaacaa
     7921 aactgcagtt gctagttgga gcaatttaag cgatttgcca gataaagatg tacttgcttt
     7981 agtcggtagt gcaactgata agcgcaatgc aggtatcatt gatatcgcca ttgatgaata
     8041 cttaaaagaa aacgatatcc ctgtcatgga cgttgaacac tttaccccat ttacttctga
     8101 cactggctat tctatggctg aagtagatgg tcacaatgtt aagttaggtt catttaagca
     8161 actttcatta atcgataaga atgcaaatga agcagttgaa ggcatcaatt ttaaagctgg
     8221 acgctcagtt gccgtgttaa ttgatgacaa acttgcggga gtatttatct tacaagataa
     8281 agtaagaaag gactctaagg ctgctttagc agaacttaaa aaacggggcg tacgtccaat
     8341 catgttaact ggtgataatc aaagaactgc cgcagcagtc gctgaacaag ttgatttaac
     8401 tggtaacgtt atctctattc atgactttga tgaaagcacc gatattgatg aattagcagg
     8461 aattgccgat gttttacctg aagataaact taagatggtt aaattcttcc aagaaaaagg
     8521 ttatatcgtt ggtatgactg gtgatggtgt taacgactct cctgctttaa agcaagctga
     8581 agttggtatt gctgtttcta acgctgccga tgttgccaag cgttcaagta agatggtgct
     8641 tctagatgat ggcttaagct ctattgttaa aattcttgat gctggtcacc gtgtatatca
     8701 acgaatgact acttggtcac ttgctaagct cgccagaacc gccgaattaa ctatgctttt
     8761 aaccttcggc tatctcttct tcaactatat tccaatggca ttaaatgcta tggttattta
     8821 cacaatcatg aataacatgg ttaccatgat gattggtacc gaccgtaccc atattactta
     8881 caaaccagaa aattggaata tggcaaggtt agccaaaatc gcattctctc ttgctgcagg
     8941 ttggacagtt atcggtatcg cttttttcag ctacctcaac atgcatggct ggagtcacaa
     9001 ttctatctct accatggtct atgtttactt agttctaagt gcaatgttaa ttgtattaat
     9061 tactagaact cgtaaatact tctggcaaga ttatccatct aaacttgtag gtattgttca
     9121 aattgccgat gtcgcattaa cctttatttt agctttatgc ggtttagcaa tggctcaaat
     9181 tagttggcaa aacttattaa ttaccgttgt ggttgcatta attgcagcaa ttattattga
     9241 tttgatttat caaccagtaa tgaaaaacag ataattaact taaaacaaaa acactctgaa
     9301 aactaaatta ctacaatgta gttttcagag tgtttttttt gattaataat tagtaactgt
     9361 agtcaaggca ttcaaagcct taacatattc accatcagca attttgataa atggtttttc
     9421 attaatttct ttatggccta aatagttaac cttagcacca cgctttaaaa atttgcctgg
     9481 gattttttca ccattctcat cataaacaaa ggaatgcttt ttgattctat taactacttt
     9541 tacagtagtc ttcatatatg gcaagaaggc ttcttcctta acaaatctat ttttacgaat
     9601 ctttacataa gtattaccat taattacttt tatggcacgt actttgtaaa gctttccctt
     9661 tcttaaatgt ccaactttaa caccatgtct attataaaca gtagcatttc tagttagatt
     9721 taatctctta ccttgtctaa ctggattagt aacaactgca tcaacgcttt gtgtagttgc
     9781 tgcgcctaat ccaataactg ctaacattat acctgcagca gaaataattt gttttctcat
     9841 cataatccac ccccgtagtg tttataccat tctccatccc ttattttatc aaaaattatc
     9901 gaattggaag cattttttac tcatctgttt tataactatt tgcttaattc tgctaaaatt
     9961 atttataaca ctacttaatt catgatttta acttgggata taatccgtag gactatcgaa
    10021 gtcttatgga ttatcaatat tgcgtttgct gtatggacgg tctttagaag tcgccgcagc
    10081 gttgttgcaa cttgggcata gatgcttgta ttaaccgttc tgcccggtat cggttttatc
    10141 ctatatcttt tctttggtcg tcagctttca catgatgaaa tctttgctat tcaagaagag
    10201 caaaaaaagg tacaaagaca ttatttagct gagcaacgcg acatgcttaa agagcacgat
    10261 cttctacctg aaaaagagcg tcttccacga gtaagaatgc tttcggaact aaatcttaac
    10321 aacgatgatg cgattttaac ttttgataat caggtcaaag tatttatttc tggaccagaa
    10381 ctttttgacc aaatgattac tgatatcaaa aatgccaaaa aatctgtcag cttagaatta
    10441 tatacttttt attctaacca attagggcat cgtgttttaa aagccttgga agaggctgca
    10501 gctaatggtg ctaaggtaag agtaatttat gatacctctg gatcaagagg cactaagcca
    10561 agcttttttg accatttaag ggcggcgaag ctcagccatt tatttccact tcaaaaaagc
    10621 actggtttac taccccacga ctcaattacc acttacatag aaaattagtt attattgacc
    10681 accatattgg ctatattggc ggatttaata ttggagatca atatgtcaat aaatcaccaa
    10741 aattcggtca ttggcgggat acccatttac gtgtaattgg gcaatcacca attctaatgg
    10801 aggtccggtt tgcaatggac tggaacacgt caatcagaag aacaaattta cctaaatttg
    10861 aattaaagga acttaaacca tttactgtca atcgaaaaga tatcaatgat aataaaaatg
    10921 tcgctatgca aattgtttcc tcaggacctg ataatcaaca ttacggcatc agacgaggct
    10981 gagggaatta ttgcaggagc taaaaaatac atttatattc aaacgcctta tttaattccc
    11041 gaagaatcaa ttcttgaagc cttaattatc gctgctaaca gcggtattga tgttcgaatt
    11101 atggttcctt gcatgcccga tcatccattt gtttatcgtg ctacagaata ctatgctaag
    11161 tatttagtag cccatggcgt taaagtatac aaatataatg atggttttat tcatgcaaaa
    11221 actatggtta gcggttctaa tatttcttca gttggttccg ccaatcaaga tttccgaagc
    11281 tatacattaa actttgaggt aaactcattc aactacaacc ctgctttaac tcaagaatta
    11341 aagaaaattt ttgagaagga cttagataaa tgtacccttt taactaatga ctactttgct
    11401 caacaatcat catggttaaa atttaagcaa tacttctcaa gattattatc acctattttt
    11461 taatgaaaag ccctctatcg gtctatccga tgggggtttt actttgtatt ttaaaaatgc
    11521 agttttattt ctttacttat tttttataag ttatataata atgataacta ttaaaaagta
    11581 aggaggataa aacttggcta atagagtaaa aataggcgtt ttgaatttaa tgcacgataa
    11641 gttagatact caacaaagat ttgcacgcgt tttgccagat gcagacctga ctttctttta
    11701 tccacgtatg cattatcaaa atcgtcctgt cccacctgaa gttgcaaaaa cttcccagcc
    11761 attagatctt aatcaaatca aagagtttga tggctttatc attacgggcg cacctttaga
    11821 tcatcttgat tttgatcaag ttacctacat cgaggaagtc cgatgtttgc tccaactatt
    11881 agataaatac aagttgcagc aattatattt ttgctggggt gcaatggccg ctttagatta
    11941 tttttacaat attcaaaaaa gaattttatc gaaaaaaatc tttggtgttt ttcctcattt
    12001 aattatcgaa ccacatcctt tattaaatgg actcagcaaa ggatttatcg ctccacatgc
    12061 tcgttacgct gaaatggata aaacacagat tatgcaagat ccacgattaa ccattaattc
    12121 agttgacgat aatgggcatc tatttatggt ctcttcttta gaaaagcctg agcaaaattt
    12181 tattttctct catatcgaat atggccgaaa aggccttaaa aaagaatatg aaagagagat
    12241 tgctgcacat ccagagcgac attataagaa gccagaaaat tattcattat caaatctatt
    12301 gtttcaatgg aaagatactc agaaaacatt tttcaataac tggctaactc aagttaaaaa
    12361 aagcaaatta gtattattag ataaataaaa cgaggcatac attatgtcta caatttataa
    12421 ttcagttaca gaacttatcg gcaacactcc attacttaag ttgaatcgcg ttgtacctga
    12481 cgacgcggca gatgtctatg taaagttaga atttgaaaac ccagctggtt caattaaaga
    12541 cagaattgct ttagctatga tcgaaaaagc tgaacgtgaa ggcaacctaa agccaggtgg
    12601 cacaattgta gaacctactt caggcaatac cggtatcggt ttagccatgg ttgctgcagc
    12661 taaggactat cacattatta ttgttatgcc agaaactatg agcgttgagc ggcgtaaatt
    12721 aatgaagggc tatggtgctg aacttatttt gacaccaggt gcagacggta tgaagggttc
    12781 aattgctaag gccgaagaat tagttaaaga gaaaggctac ttcatgccaa tgcaatttga
    12841 aaatacagaa aatcctaata ttcatgaatt aactactggt ccagaaatta ttgccgcaat
    12901 gaatggtatc ggcaaatccg ttgatgcctt tgttgctggt gttggtactg gtggtacttt
    12961 atcaggaatt ggacatgcac ttaggcgtga aaatccatcc actaagatat ttgcacttga
    13021 gccaactgaa tctccactct taaaagatgg aaaaacaggt aaacatggta tccaaggtat
    13081 tgccgcaggt ttcatcccta agaatttaga taaggatatc tacgatgata taattacagt
    13141 ttctactgat gaagcaatgg ctacagctcg tgaagtagct aaaaacgaag gcttcttacc
    13201 tggtatttca gctggtgcaa acatccatgg tgcaatcgaa attgctaaaa agttaggcaa
    13261 gggacatgct gtggttactg tagttccaga cggcggtgat cgttaccttt caactgcatt
    13321 atttaatgct taaaacttaa tttctgtaaa caaatactcc taagtaaaat ttccttagga
    13381 gtattatttt tatttctgtt gattgtgcac cagtcaatgt tggtacaaca cttttagtat
    13441 aatgaccttt actaattaga tcaatattga atttatttaa gcaccatgat attgcactaa
    13501 gctgtaaata tcaacatcag gcaacttttc tctacccttt aaatcaggca attcaatgta
    13561 aaatgcagca cctacaagct taccaccaag attttcaatt aattccttag aagctcttaa
    13621 agtacctgca gtagccatta aatcgtcaca gagaacaact ctttggccag gcttaattgc
    13681 atctttatgc atttcaaggc tatttgaacc gtattccaag tcatatgaag cacgttcaac
    13741 ttctcttggc aacttatgtg gctttcttgc tggaacaaaa cctaagccta actcagttgc
    13801 aacaggacag cctacaataa agccacgtgc ttcaggacct acgattacat ctgcctttct
    13861 actctttgca tattctgcca attcatgagt agcaatacga tacaattcac catcttgcaa
    13921 aataggtgta atatcgcgaa agacaattcc cttattagga aagtccttaa cacttgcaat
    13981 atatttacta aaatcaatcg ccataagaag aaaaacctcc ataattctgt gcgtttgtat
    14041 tcaaacactt ttgacttgta tattttacca aagatttgtt ataaaagtac tgaaatcttg
    14101 atatttatct atctttttac caaattatta acatatgtaa ttaatttttg agtaggcatc
    14161 gttcttagtt gattaataaa tttaatttgt gaactcgttg ccattaaata tttagaagct
    14221 gtcaatggtt gcttctttgg attagactca ccaactaatt tttgatcgtc taatttaaca
    14281 aaacctaatt caaagaatac tcgcaaaata aacaatacac tatcataatc caaacctaga
    14341 tatggtgcta cagtgcgata gtcttcaggc tttaatgctg gatgggcata aatatacttt
    14401 aacacttttc cgaaataact ctttgctgga atttgttcaa caggtaactg atctaataaa
    14461 aagcataaat aaatttgttg ataatctttt tttaaagctg catttaattc cacttgattg
    14521 cgaggcacat caagcaaagc tactgtttca cccgattgat cataatcttt aaccaagcta
    14581 attttatcat catcaatttg aaggctattc ttaacaattg gaatattctt tttgtcaaaa
    14641 agcaaataac gatctgcaag gcccatgaca aatttctctt gtcttaaatc aattactgat
    14701 gttggcacag ctaattttgg ggatgcaaag gctattcctt ccatgatgcc ttgcaaagat
    14761 acttgtttgc gataagtatt caaagagaga gtaacaaaga tttttgaaat aaatggtaac
    14821 aaattattat tcaaataatc cttattaaat cccacaattg ctaaattgcc gtctttttta
    14881 ttagctatta atttaacatg attcttatct tttcctattt tgaaaaagtg tgtaatagtt
    14941 ggatccgaaa tactaaaaat tggctgcgga tcaccagtac caaatggtcc cacttgatta
    15001 atttgagcca aagtttgagg tgataagtca tgcataggca attccatatc gtactcttta
    15061 gtctctaaac caccgtcaac atgaaaatcg gcttcaaact tttcccgtag gtcatttact
    15121 ttatcttctt ccatggataa accacaagca aaatcatgac ctccaaattt ggtcaataga
    15181 ctttctttta acggattaag agcatcaaat aagttaaaac cactgagtga acgacctgat
    15241 cccttaatct ccccttcatc gtttttagtt aaaacaattg ttggtttatg cagtttttcc
    15301 actatcttgt tagcaacaag ccccaaaact ccttcatgaa aatcaggatc atataaaact
    15361 aaagtatttt gcttttgcca actattttca cgaactaatt ccatgcagcg atcgtaaacc
    15421 tcagtagtta gctctttacg cttattattt aagtcttcaa tctgatctgc gatcttctgt
    15481 gcctcaagat catcatcact aagcaaaagc tctactgcca gattagcatt agccaaacgt
    15541 ccaacagcat taagtctagg agcaatatta aagcctacat ctgtctcatt aatcgtttct
    15601 agcgttaaac cggcattttt gataagcgct cttaagcccg gtcgttcggt ttgattaaga
    15661 acatctaacc cacgttttac aataatatgg ccttcaccag taactttaac catgtcacca
    15721 atagtaccga tcattgctaa atctagcaat tctggtacag gatcctgcat aagctcacga
    15781 caaattgtat aagctacacc tgcaccacaa taatcatcaa aaggatattc ttgaccagga
    15841 taattacagt gaacaattgc ataagcatct ggcttatttt cttgaaaagt atggtgatcc
    15901 gtaataatag tatcaacgcc atgttcttta gcgtattcaa cttct
//
