LOCUS       gnlProkkaLBGLJAEN_23   13871 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LBGLJAEN_23.
ACCESSION   gnlProkkaLBGLJAEN_23
VERSION     gnlProkkaLBGLJAEN_23
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 02:51:18
            Original ID  :: gnl|Prokka|LBGLJAEN_23
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 139007
            Orig. end    :: 152878
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13871
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:8871]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..8871
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..13871
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13871
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     CDS             228..1613
                     /gene_functions="transport (smcogs) SMCOG1169:sugar
                     transport protein (Score: 438.3; E-value: 5e-133)"
                     /gene_kind="transport"
                     /locus_tag="ctg21_135"
                     /transl_table=11
                     /translation="MKKDTRKYMIYFFGALGGLLYGYDTGVISGALLFINNDIPLTTLT
                     EGLVVSMLLLGAIFGSALSGTCSDRWGRRKVVFVLSIIFIIGALACAFSQTIGMLIASR
                     VMLGLAVGGSTALVPVYLSEMAPTKIRGTLGTMNNLMIVTGILLAYIVNYLFTPFEAWR
                     WMVGLAAVPAVLLLIGIAFMPESPRWLVKRGREEEARRIMNITHDPKDIEMELAEMKQG
                     EAEKKETTLSVLKAKWIRPMLLIGVGLAIFQQAVGINTVIYYAPTIFTKAGLGTSASAL
                     GTMGIGILNVIMCITAMILIDRVGRKKLLIWGSVGITLSLAALSGVLLTLGLSASTAWM
                     TVVFLGVYIVFYQATWGPVVWVLMPELFPSKARGAATGFTTLVLSAANLIVSLVFPLML
                     SAMGIAWVFMVFSVICLLSFFFAFYMVPETKGKSLEEIEASLKKRFKKKKSTQNQVLNE
                     RTL"
     CDS             complement(1655..3535)
                     /locus_tag="ctg21_136"
                     /transl_table=11
                     /translation="MAKKEFKAESKRLLDMMINSIYTQKEIFLRELISNSSDAIDKIYY
                     KALTDDALTFDKDSYYIKVAADKDARTLTISDTGIGMTKDELEQHLGTIAKSGSLAFKK
                     ENELKDGHDIIGQFGVGFYAAFMVADVVTVISKALGSEEAYKWESAGADGYTIEPCEKD
                     SVGTDIILKIKENTEDDSYDEFLEEYRLKAIIKKYSDFIRYPIKMDTTINKPKEGSENE
                     FEEVQEEQTVNSMVPIWRKNKSELTDEDYEKFYAEKHYGFDKPLTHVHISVDGAVRYNA
                     ILFVPENMPFDYYSKEYEKGLELYSNGVLIMNKCADLLPDHFSFVKGMVDSEDLSLNIS
                     REMLQHDRQLKLIAKNISKKIKSELQSLLKKDREKYETFYKSFGRQLKFGVYNDFGANK
                     DQLKDLLLFYSSKEKKLVSLDEYVSRMPEEQKFIYYATGDSYDRIEKLPQTEMVADKGY
                     EILYFTEDIDEFAIKMLASYQEKEFKSVSSGDLGIDTDEDQKQSEEEESKYKDLFEEMK
                     NILSDKVKNVRISKRLKSHPVCLAADGEVTIEMEKILNAMPDSQNVKAEKVLEINPNHE
                     VFQTLQDAFEQDKEKLSLYTNLLYNQALLIEGLPIQDPVEFTNNICKVMV"
     CDS             4065..4886
                     /NRPS_PKS="Domain: PKS_KR (7-160). E-value: 1.3e-09. Score:
                     30.0. Matches aSDomain: nrpspksdomains_ctg21_137_PKS_KR.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     247.1; E-value: 3.1e-75)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg21_137"
                     /sec_met_domain="adh_short (E-value: 2.5e-33, bitscore:
                     109.6, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 1.5e-37, bitscore:
                     124.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGRLENKTAVITGAATGIGQATAEVFANEGARVMIGDINEDQMKE
                     TVEAIRQNGGQADAFHLDVSDENSVKAFADQIKEACGTIDILFNNAGVDQEGGKVHEYP
                     VDLFDRIIAVDLRGTFLCSKYLIPLMLEKGGSIINTSSMSGRAADLDRSGYNAAKGGIT
                     NLTKAMAIDYARDGIRVNSISPGTIETPLIDKLAGTKEQEMGEKFREANKWVTPLGRLG
                     QPKEMATVALFLASDDSSYVTGEDITADGGIMAYTWPGKMLLDEKWKEETK"
     aSDomain        4086..4544
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg21_137_PKS_KR.1"
                     /evalue="1.30E-09"
                     /label="ctg21_137_PKS_KR.1"
                     /locus_tag="ctg21_137"
                     /protein_end="160"
                     /protein_start="7"
                     /score="30.0"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="TAVITGAATGIGQATAEVFANEGARVMIGDINEDQMKETVEAIRQ
                     NGGQADAFHLDVSDENSVKAFADQIKEACGTIDILFNNAGVDQEGGKVHEYPVDLFDRI
                     IAVDLRGTFLCSKYLIPLMLEKGGSIINTSSMSGRAADLDRSGYNAAKG"
     CDS_motif       4092..4160
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg21_137_0001"
                     /evalue="7.70E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg21_137"
                     /protein_end="32"
                     /protein_start="9"
                     /score="15.4"
                     /tool="antismash"
                     /translation="VITGAATGIGQATAEVFANEGAR"
     CDS             complement(5001..5225)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg21_138"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 3.5e-09,
                     bitscore: 31.0, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENNNRFSELNVKEMEQIDGGGWRSALGGAFSGALVGASTVGVGG
                     AAVGGPVGGVGGAITGGIVGGIVGGINEW"
     CDS             complement(5243..5473)
                     /locus_tag="ctg21_139"
                     /transl_table=11
                     /translation="MDTKSIKDVELQALTLEEAEQIDGGSYAKYLGTSVVTGAGAGVVG
                     GVPGVILGAHAGAIAGSVGYLGGSLIAGKWL"
     CDS             complement(5662..6087)
                     /locus_tag="ctg21_140"
                     /transl_table=11
                     /translation="MKDERISHIENKIGHESFLLVIALVFVSFILSIMFKIPSTLMTII
                     ILFVGSGYYGLRAMSKGILRVNLKKKKKSSYFLLIVFTFILYMATSILFKIITFPFTTK
                     EFLFQILMYILWLIPFSLIMYTTYKFSNRQQKKELEN"
     CDS             complement(6077..6295)
                     /locus_tag="ctg21_141"
                     /transl_table=11
                     /translation="MNNNLKLERTRANLTQEQLAEKIGVTRQTIGLIEKGKYNPSLQLC
                     LKICIELKVTLNDVFWTYNREEESNEG"
     CDS             6440..6592
                     /locus_tag="ctg21_142"
                     /transl_table=11
                     /translation="MKLFYSYIIAGGLFCISLSYFFHLGVFNLALYLIYINYAFILYKR
                     AKSSK"
     CDS             6688..8871
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 302.4; E-value:
                     1.1e-91)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg21_143"
                     /sec_met_domain="Peptidase_C39 (E-value: 5.5e-44, bitscore:
                     143.3, seeds: 36, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR01193 (E-value: 1.7e-237, bitscore:
                     784.3, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFFNRYHCVRQLDQKDCGAACLSTIAKHYGSKLSLAYIRDIAGTD
                     TQGTSALGMVKAAEQLGFSAKAVRAEHTAFDQSITLPAIAHIIIDQQLLHYVVIHKISK
                     DKIIIADPGKGLVTYQKDDFFKIWTGILILLAPTETYKKQTETSNISADIFRLILQQKS
                     LIIHTFLASFIITIFGILGTFYFQTIIDQILPNGLSNTLHILSIGLLIMYLFKVFLIGF
                     RQYLMILLGQKLSISIMFGYFQHVLTLPMKFFSNRKVGEIISRFTDANKVIDAVVSASL
                     SVILDTIMLIMVGIFLYLQNTTLFLITLAFIPFYILTVWIFIKPYENINNTEMENNAQL
                     TSKIVETLNGIETVKAYNAEYMMSFETEKRFVKYLRSAFKHGVIDNLQSSIKMFLDLAS
                     GALILWIGSTQVMKGTLTIGQLITYNALLTYFLNPLQNIIGLQSKLQSASVASKRLGEI
                     LKLEPELKEKEAQITSTSSITGPLSFNKINFRYGTRRLILKDITLHIQKGEKVAFVGES
                     GSGKSTLTKLLMKFYTAESGEVLINGYHINDIHTNALRESISYIPQESHFIQGSILENL
                     LLGNSGSFTFEEIIEVCKQTNVHDFVNDLPMRYDTLVEENGSNLSGGQKQRLAIARALL
                     RKPNILIMDESTSNLDTTTEQGISKMIYDQTVGITTIIIAHRLSTIMNCDKIFVMENGE
                     IIEYGNHNDLLKKKGKYYELWENQMPSRGMVTI"
     CDS             8872..10341
                     /gene_functions="transport (smcogs) SMCOG1029:RND family
                     efflux transporter MFP subunit (Score: 71.6; E-value:
                     9.3e-22)"
                     /gene_kind="transport"
                     /locus_tag="ctg21_144"
                     /transl_table=11
                     /translation="MKRNFFNLHDLKDSREFYESKPKPIGVFFTYILIALLIACIVFSF
                     YGKKEVILKTTADIQYTKPNSNVTNEVAGKVKTVDIKQVDKVKKGDTLLTLDNTEIQAQ
                     KKAVKADIKDLKEQAALNKTLKKSIENDKNLFSEDDHWGYQDQYLSYEKQSILLESSKE
                     NAKTQQKKLKKQKESIKDSLDKTKNKVKLKLQRISDLQDSIKNNKSFAKQDDKYSSYYN
                     SYQTNKQNVEQQLDDLRKMKDELDKNRFSQQKENLNGQLESLKQDMLVKLSEEKDELNQ
                     SLDEINSSIKSDDSDSDSDNSEETNYKLSIEQLKTNLLNQTSQKQTDLQTTLKSKEDDL
                     KMIDLQLEKYKIKAASDGYVNVLTNISPGDNLQAGTAILTIIPDKEKLKANIYIPSHEI
                     TNINEKDEVRFHIENTNQTIKGVITKISPDSISDQNGQKFYIAESTIEKNKVMNDNGST
                     LHLKNGMQTDVSIIVDSKRYIDYLLEILHLQ"
     CDS             complement(10859..12001)
                     /gene_functions="regulatory (smcogs) SMCOG1057:TetR family
                     transcriptional regulator (Score: 41.4; E-value: 3.5e-12)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg21_145"
                     /transl_table=11
                     /translation="MPESAEAQVKQALLALLEERDMQHITMKEIAERAKVSRGTLYLYY
                     EDKFSIIEDLIEDMKEGLGKALFDAFSHLDTLHLNKKRQTVHPTLSFVHEHRSFFSVMM
                     NRGHFHRFFKDVFHHDVLLAPIHVNLTPIEREIYGHYRALYTYAIILYWLNEDAAAAPE
                     AISQKVWELVSQKRFYWLFGQAVPGEREKGKPIDRRVVRTREALQQAFLDVLAEKQDYA
                     GITISDITRKSNIRRATFYDHYANKEELLRTMIQRSCAEIIDHLTIASSPNEFSLKEAE
                     KALASLLSALSNMPIVHFLNREWGVPHVIPDMFKALESFYLHQQTDIHAEKKLYAHYVS
                     AMIIGLLLYRLDEGKAHEPEVLAREFLQFLDVKKYKVVLL"
     CDS             12144..13481
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017:aldehyde dehydrogenase (Score: 303.6; E-value:
                     3.1e-92)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg21_146"
                     /sec_met_domain="Aldedh (E-value: 3.6e-101, bitscore:
                     333.0, seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEQKVKDDIQRVFQLQKKQQKALRASTAEQRKEKLQRFLDSVIAH
                     EEEIIEAIRKDVRKPYHEVKKAEIEGTKKAIRDNMNNLEQWMAPKEVGSSLSPEANGIL
                     MYEPKGVTLILGPWNYPFMLTMAPLAASLAAGNSAIVKLSDFTMNTSNIAAKVIRDAFD
                     EKEVAIFEGEVEVATELLDQPFDHIFFTGSTNVGKIVMTAAAKHLASVTLELGGKSPTI
                     IDSEYDLMDAAKKIAVGKFVNAGQTCIAPDYLFIKKDVQDRFAGILQTVVNAGFMEDDH
                     TPDRSKFTQIVNDRNFNRVKDLFDDAIEKGAEVVFGGVFDASDRTISPTVLKNVTPDMK
                     IMQEEIFAPILPMMNYEDIDEVIDYVNDRDKPLALYVFSKNQDMIDNVLQHTTSGNAAI
                     NDVVVHFSDVNLPFGGVNTSGIGSYHGVYGFKEFSHEKGVFIQASK"
ORIGIN
        1 atcaaaacct tactccgcgc gggtaaggtt tttttaatgg tttctctgag cataaagtta
       61 tttcgttttt cctaaactca gcggatctgt gatcatctct tttggcttta acgtttccgt
      121 tttttcaaaa caaatgtttc aaatgagata ggaaatgggt actaatctat taactttgtt
      181 atacatttta gatactcatt ggctcaacaa ctgaggagga gacatttgtg aagaaagaca
      241 caaggaaata tatgatctac tttttcggcg ctttaggggg actgctatat ggttacgata
      301 caggtgttat ctccggagca ctcctgttta tcaataacga tattccttta acgacattga
      361 cagaaggatt ggttgtcagc atgctgctcc ttggcgcgat tttcggttct gccttgagcg
      421 gcacatgctc cgaccgctgg ggcaggagaa aggttgtatt tgtcctttcc atcattttca
      481 ttatcggagc gctcgcttgc gcgttttctc aaacaatcgg catgctgatt gcatctaggg
      541 tgatgctcgg gttggccgtc ggcggttcaa cggcgcttgt gcccgtgtat ctttccgaaa
      601 tggcaccgac gaaaattcgc gggacactcg gcacaatgaa caacttaatg attgtcaccg
      661 ggattttgct cgcctatatc gttaactatc tgttcacacc gtttgaagcg tggcgctgga
      721 tggtcggtct ggccgcagtg cctgccgtgc ttttattaat cggcatcgcg ttcatgccag
      781 aatcgccaag atggctcgtg aagcgcggcc gtgaagaaga agcgagacga atcatgaaca
      841 tcactcatga tccaaaagac atcgaaatgg aattggcaga gatgaagcaa ggagaagcag
      901 agaaaaaaga aacgacactc agcgtcctaa aagccaaatg gattcgcccc atgcttctga
      961 ttggcgtcgg ccttgccatt ttccagcagg cggtcggcat taacacggtc atctactacg
     1021 cgccaaccat ttttacgaag gccggtcttg gcacatcagc ttcggcgctc ggcacaatgg
     1081 ggatcggcat cctcaacgtc atcatgtgta tcactgccat gatcttaatt gaccgtgtcg
     1141 gccgcaaaaa acttctgatc tggggaagtg tcggcatcac actgagcctt gctgctttat
     1201 caggcgtgct cctaacgctc ggactttccg catcaacagc gtggatgaca gtagtctttc
     1261 tcggtgtcta tatcgtcttt taccaggcga catggggtcc ggtagtgtgg gtgctcatgc
     1321 ctgagctctt cccgtccaaa gcacgcggag ccgcgacagg gttcacgact ttggtgttat
     1381 cggcggctaa cctgatcgtg tcgcttgtct ttccgctgat gctaagcgcg atgggcatcg
     1441 catgggtctt tatggttttc tcagtcattt gtcttctctc atttttcttc gcgttctaca
     1501 tggtgccgga aaccaaaggg aaaagcttgg aggaaattga agcaagcctg aaaaaacggt
     1561 ttaaaaagaa gaaaagcacc caaaaccaag tgctgaatga gcgtacatta taaaaaaagg
     1621 aatcgtctcc ttatgggacg attccttttt ctgtttacac catgaccttg caaatattgt
     1681 tcgtaaattc cacagggtcc tgaatcggca ggccttcgat gaggagcgcc tgattgtaca
     1741 gaaggtttgt gtacaggctc agcttctctt tatcttgttc aaacgcgtcc tgcagtgttt
     1801 ggaatacctc gtgatttggg ttgatttcca gcactttttc cgccttcaca ttttggctgt
     1861 caggcatcgc atttaagatt ttttccatct caattgtcac ttcgccgtca gcagcaaggc
     1921 agactggatg tgatttaagc cgttttgaga ttctgacgtt tttcactttg tctgacagaa
     1981 tgtttttcat ttcctcaaac agatccttgt acttgctttc ctcttcctcg gactgctttt
     2041 gatcctcatc cgtgtctatg ccaaggtctc cgcttgatac ggacttgaat tctttttcct
     2101 gataagaagc cagcatttta attgcaaact catcgatgtc ctcagtaaag tagaggattt
     2161 catagccttt gtccgccacc atttccgttt gcggcagttt ctcaatgcgg tcgtaagaat
     2221 caccggtcgc gtaataaatg aatttctgct cctctggcat tctggaaaca tactcgtcta
     2281 agctgaccag ttttttctct tttgaagagt agaataagag gagatccttc aattgatcct
     2341 tattcgcgcc aaaatcattg tacacgccga atttcagctg tctgccgaac gacttgtaga
     2401 acgtctcgta tttctcgcgg tcttttttca acaggctttg cagctcgctt ttgattttct
     2461 tgctgatgtt tttcgcgatc agcttcagct ggcggtcatg ctgcagcatt tctctggaaa
     2521 tgttcagcga cagatcctca gaatcgacca tgcccttcac aaagctgaag tggtccggta
     2581 gcaggtctgc gcacttattc atgatcagca cgccattgga atacagctcc aagcctttct
     2641 catattcctt ggaatagtag tcaaacggca tgttttcagg gacgaataga atcgcgttgt
     2701 agcgaacggc tccatctaca ctgatatgaa cgtgtgtgag cggtttatca aacccgtaat
     2761 gcttttcagc atagaatttt tcataatcct catctgtcag ctcgcttttg ttttttctcc
     2821 agatcggcac catgctgttg accgtctgct cttcctgcac ctcttcaaat tcattttcgc
     2881 tgccttcctt cggcttatta atggttgtat ccattttgat cgggtagcga atgaagtcgg
     2941 agtacttctt gatgatcgct tttaaacgat attcctctaa aaactcgtca tagctgtcat
     3001 cttctgtgtt ctctttgatt ttcaggataa tgtctgtacc gacagaatcc ttttcacacg
     3061 gttcaatcgt atagccgtct gcacccgcag actcccattt ataagcctct tcgctgccca
     3121 gcgctttact gatgactgtc acgacatcgg caaccataaa tgccgcgtaa aaaccgacac
     3181 cgaactgccc gataatgtca tgtccgtctt tcagctcgtt ttccttttta aacgcgaggg
     3241 aaccgctttt tgcaattgtt ccaagatgct gttcaagctc atcctttgtc attccgatcc
     3301 ccgtatcaga gatggttaat gttctcgcat ctttgtcagc tgcgaccttt atgtagtaac
     3361 tgtctttatc aaacgtaagc gcatcgtccg taagcgcttt gtaatagatt ttgtcaatcg
     3421 catcactcga attggagatt aactcgcgca ggaaaatttc tttttgggta taaatggagt
     3481 taatcatcat atccagcaag cgtttagact ctgctttaaa ctcttttttt gccactcttg
     3541 atcgctcctt taccattatg taaacccttt tcagcatcta tttatcacat aagatgacaa
     3601 ttgtcaatta gattgataga tgcatatata tgtaaattta acattagttg gatttgtttt
     3661 cactcttttt ctcactcatt ctcataaaaa agagaggctt catcatcctc tctttttttc
     3721 tgtgtcattc cagcggccaa actcccgctt catccaaata tgcaccggat agaaaaacaa
     3781 accgaacggt atcaaaaata atagattatg ccatgaagca tttagaaacg cgcttgctgt
     3841 aactggaaat gtaatctctt tgaatagaaa cgagatgaga gtcagcagaa taaatgcaga
     3901 tggaattgta acgaagcaat aaaacttgag ctccttctta tgctggattt tcaactcaca
     3961 caccccccaa ccaatttcca gcctatctta acacatgcat ttcctttctc gcatgtttat
     4021 gactgcacag agcgggaaga caaatagaaa aaggaggtcg tgtcatggga agacttgaaa
     4081 acaaaaccgc agtgatcaca ggcgccgcga caggcattgg acaagcgacg gcagaggttt
     4141 ttgccaatga aggcgcgcgt gtgatgatcg gggacatcaa tgaagaccaa atgaaagaaa
     4201 cagttgaagc aatcagacaa aatggaggac aggcggacgc ctttcacctc gatgtgtcag
     4261 atgaaaacag cgtgaaagct tttgctgatc aaatcaagga ggcgtgcgga acgattgata
     4321 ttttgtttaa taacgccggc gttgatcagg aaggcggaaa ggtgcacgaa tatccggttg
     4381 acctgtttga ccgcattatc gccgtcgacc tgcgcggcac attcctttgc agcaaatatc
     4441 tgattccgct catgctcgaa aaaggaggct ccatcatcaa cacctcctcc atgtcaggcc
     4501 gggccgcgga ccttgaccgc tccggctaca acgcagcaaa aggcggcatc acaaacctga
     4561 caaaagcgat ggcgattgac tacgcacggg acggaatccg cgtcaattcc atttcgccgg
     4621 gtacgatcga aaccccgctg attgataaac tagcgggcac caaagaacag gaaatgggcg
     4681 aaaagttccg cgaagcaaac aagtgggtca caccgctcgg acgcctcggc cagccgaaag
     4741 aaatggcgac ggtggcgctg ttcctcgctt cagacgacag ctcatacgtc acaggagaag
     4801 acatcaccgc agacggcggc atcatggcgt atacatggcc tgggaagatg ctgttagatg
     4861 agaaatggaa ggaggagacg aaataaacat gctgcgcaat tttatgcgtt aattaacaat
     4921 tataaaatat aatacgaccg ggaagagaag actcttgccg gtcgtatacc atagtactaa
     4981 actagtcgtt tatgtatttt tcaccattca ttgattccgc cgacaatgcc gccaactata
     5041 ccgccagtaa tagctccgcc gacaccgcca acagggccgc caacagctgc tccaccgacg
     5101 cctactgttg aagcaccgac taatgctccg gaaaaagctc cgccaagagc acttctccag
     5161 cctccgccat caatttgttc catttctttt acgtttaatt cagaaaaacg attattattt
     5221 tccattgatg tgttatccct ccttaaagcc attttcctgc aattaatgat ccgcctaaat
     5281 aaccaactga tcctgcaatt gcacctgcat gggcaccaag aataacacct ggaactcctc
     5341 caactacacc cgcaccggca cctgtaacaa cagaagtgcc aagatatttc gcataactgc
     5401 ctccatcaat ttgttcagct tcttcaagag tcaatgcctg aagttcaacg tcttttatgc
     5461 tttttgtgtc catcaatatt cctcctcgaa gttattcagg taaataatta ctagtataaa
     5521 tttaccacgt ggattatgat attacataat aaatcctaaa tcaatagttt tttccataaa
     5581 aatatatata acctatcatc aatttatata tagtaaaaga gagcttaacc taattcagtt
     5641 atttaggtta agctctctta attaattctc taattctttt ttctgctgcc tgtttgaaaa
     5701 tttatatgta gtatacatga tgagactaaa aggaattagc cataagatat acataagaat
     5761 ttggaataaa aattctttag ttgtaaaagg aaatgtaatg attttaaata atatcgacgt
     5821 tgccatatac agaataaaag taaaaacaat taaaagaaag tacgaacttt tcttcttctt
     5881 tttcagattg actcgtaaaa taccttttga catagctctt aatccataat atccgcttcc
     5941 aacaaacaat atgataattg tcattaacgt actcggtatt ttaaacataa tcgaaagtat
     6001 aaaagagaca aaaaccaaag caattactaa aagaaagctt tcatgaccta tcttattttc
     6061 aatatgactt attctctcat ccttcattag attcttcctc cctgttatac gtccaaaata
     6121 catcattcag agtaactttc aattctatac aaattttcaa acataattgt aaagaaggat
     6181 tatacttccc tttttcaatt aatccaatcg tctgtcttgt cactccaatt ttttcggcaa
     6241 gttgttcctg tgttaaattc gctcttgttc tttccaactt caaattatta ttcattggca
     6301 agtctccatt ggtttattta tctgtagcat atcatacatg aaaaaaccat gcaaactata
     6361 tattgcattt atccatatat attttacatt ttgtccatta tatcttacaa tgaatttaac
     6421 atttatagga gttggtaaaa tgaaattgtt ctatagctat ataatcgcag ggggtttatt
     6481 ttgtatatct ctttcttatt tttttcactt aggtgtattt aatcttgctt tatatcttat
     6541 ctatatcaac tacgcattta tattatataa acgtgccaaa agctctaaat agcaataaat
     6601 atttacctga aaaaggttga caaaccctga aaatgtaata aaatgatgtc tattctaaaa
     6661 aatgaccttc attatggaga gtagtatatg ttttttaata gatatcattg tgtacgacaa
     6721 cttgatcaaa aagattgtgg agcagcctgc ctatcaacaa ttgcaaaaca ttatggttca
     6781 aagctctccc tagcttatat acgtgacatt gctggaactg atacacaagg tactagtgct
     6841 cttggaatgg taaaagccgc cgaacaattg gggttttcag caaaagccgt gcgtgcagag
     6901 catacagctt ttgatcagtc cattacgctt ccagcaattg cacatattat tatagatcag
     6961 caattattgc attacgttgt tatacataaa attagtaaag ataagattat cattgcggat
     7021 cctggaaaag ggctcgttac atatcaaaaa gatgattttt ttaagatttg gacaggcatc
     7081 ttaatacttt tagcacctac tgagacttat aaaaaacaga ccgaaacaag taatataagt
     7141 gccgatattt tcaggttgat tcttcagcaa aaatcgttga ttatacatac gtttttagca
     7201 tcctttatta ttaccatctt cgggatcctc ggtacttttt actttcagac gatcatcgat
     7261 caaatcctgc ctaatggatt aagtaacaca ttacatattc tttcaatcgg ccttttgatt
     7321 atgtatttat ttaaggtttt cttaataggt tttaggcaat acctaatgat tctcctagga
     7381 caaaaattaa gtatctccat tatgtttgga tactttcaac atgtgcttac tttgccaatg
     7441 aaatttttca gtaatcgaaa agtcggagaa attatatcca gatttactga tgctaataaa
     7501 gtgatcgatg cagttgtcag tgcatcgctt tcggtcatac tcgataccat tatgcttatt
     7561 atggttggta ttttcttata tctgcagaat actactttat ttctcatcac attggctttc
     7621 ataccttttt atattttgac ggtttggata tttataaaac cctacgaaaa tataaataac
     7681 acagaaatgg aaaacaatgc gcagctgact tcaaagattg ttgagacgct taacggcatc
     7741 gaaactgtta aagcatacaa tgcggaatat atgatgtcat ttgaaacaga aaaaagattt
     7801 gtgaaatact tacgatcagc ttttaaacac ggagttattg ataatcttca gagttccata
     7861 aaaatgtttt tggatttagc aagcggtgca ttgatactgt ggatcggatc aactcaggtc
     7921 atgaaaggca cccttactat cggtcagctt attacatata atgccttatt aacctacttc
     7981 ttaaatcctt tacaaaacat catcggccta caatctaagc ttcaatcagc ttctgttgcg
     8041 tccaaaaggc tcggagaaat tctaaagcta gaacccgaat taaaagagaa agaggcacaa
     8101 ataacatcga cgtcgtcaat tacaggtccg ctttctttta ataaaatcaa ttttcgatac
     8161 ggaactcgaa ggctcatctt aaaagatatt acactgcata ttcaaaaagg agagaaagtt
     8221 gcctttgttg gagaaagcgg ttcaggaaaa tctactttga ctaagctttt aatgaaattt
     8281 tatacagctg aatcaggtga ggttttaatc aatggttatc atataaatga tattcacacc
     8341 aacgcgttaa gggaaagtat aagttatatc cctcaagaat ctcattttat acaaggatca
     8401 attcttgaaa accttttgct cggtaactca ggcagtttta cctttgaaga gattatagaa
     8461 gtatgcaaac aaacaaatgt acacgatttt gtcaatgatt taccaatgag atacgatact
     8521 ctcgtagagg aaaacgggtc taatttatct ggaggccaga agcaaagact cgcaattgcc
     8581 agagcattat taagaaaacc taacattctc ataatggatg aatcaacaag caatctcgat
     8641 acgactaccg aacagggaat atcaaaaatg atatacgatc agactgttgg tataactacg
     8701 attataatcg ctcaccgttt gagtacaatt atgaattgtg acaaaatatt tgtcatggaa
     8761 aatggagaaa tcatagagta tgggaaccac aatgatttat tgaagaaaaa aggcaagtac
     8821 tatgagttgt gggagaacca aatgccatcc agagggatgg tgactattta gatgaaacgt
     8881 aactttttca atttacatga tttgaaggat agcagagaat tctatgaatc aaaacccaaa
     8941 ccaattggtg ttttctttac atatatactg atagctttac ttattgcatg tattgttttt
     9001 agtttctatg gaaagaaaga agtgattcta aaaacgacag ctgacatcca atatacaaag
     9061 cctaacagca acgtaacaaa cgaagtagcc ggcaaagtaa aaacagttga cattaaacag
     9121 gttgataagg tgaaaaaggg agatactcta ttaactctag acaatacgga aatccaagcg
     9181 cagaaaaaag ctgttaaagc agatatcaaa gatttaaaag aacaagctgc gttaaacaaa
     9241 actctaaaaa aaagtattga aaatgacaaa aatttattca gtgaggacga tcattggggt
     9301 tatcaagatc aatatctctc gtacgaaaaa caaagtattt tgttagagtc atcaaaagaa
     9361 aatgcaaaaa ctcagcagaa aaaacttaag aagcagaaag aaagcataaa agatagtctg
     9421 gataagacaa aaaacaaagt caaactaaag cttcaaagaa tttctgatct gcaagactcc
     9481 attaaaaaca ataaatcctt tgccaaacag gatgataagt acagttctta ctataatagt
     9541 tatcaaacta acaaacaaaa tgtagagcag cagcttgatg atctacggaa gatgaaagat
     9601 gagcttgata aaaaccgttt ttcacagcag aaagagaact tgaacggaca gcttgaaagt
     9661 ttaaaacaag atatgttagt aaaactaagt gaagaaaaag acgaattaaa tcaatctctt
     9721 gatgagatta acagttcaat taaaagtgac gattctgaca gtgattccga taactcagag
     9781 gaaacaaatt ataagctttc tattgaacag ctcaaaacaa acttgctaaa tcagacatct
     9841 caaaagcaaa cagatcttca gaccactctt aaatcaaaag aggatgatct aaagatgata
     9901 gatttacaat tagaaaaata taaaataaaa gcagcaagtg acggctatgt taatgtacta
     9961 acaaatatat ctccaggtga caatttacaa gcaggcactg ctattttgac tattatccct
    10021 gataaagaga agcttaaagc taatatttat attccgagtc atgagatcac aaatattaat
    10081 gaaaaagatg aagtaagatt ccatattgaa aatacaaatc aaaccatcaa aggtgtcatt
    10141 acaaaaataa gtccagacag tattagtgat caaaacggac aaaaatttta tattgctgaa
    10201 agcacaatag agaaaaataa agttatgaac gataacggat caactttaca cttaaaaaat
    10261 ggaatgcaga ccgatgtatc aattatagtg gattctaaaa ggtacattga ttatctacta
    10321 gaaatactac atttacaata atataataaa tataaatcca acagaggcaa tctgtttatg
    10381 ggttactcac cggtctgaaa taatgtactt agaataagtg aaccactcaa aataaactat
    10441 tatgcaattt cttttttgtg gatttatttc ttgttttatg taattatgct ataattacaa
    10501 ctaaattttc aacagaaagg tcaagcaatt tatgtcgcaa aacaaactat tatttttact
    10561 cttttcattt tcttctatca ttcacttgct cttcaatacg attttagatc ctacttcaag
    10621 ctggaaatct tggtcggtga acattgcgct aattctttta gcccttctat ttttaaattt
    10681 tactttgaaa gaaaagaaag aaactcacaa gaccaagtga cataacgaca caaagcccgg
    10741 actgactatc cgggcaaatt tatatcctgt aaacgttacc tctcttaggt tttcttttca
    10801 taacatactg aagttactct ccggccttcc atttcagcca ctggctggtt tctctcgttt
    10861 atagcaatac aaccttatac tttttcacat ccaaaaactg caaaaactcc ctcgccagca
    10921 cttctggctc atgcgccttt ccttcatcca gccgatacaa aagcaacccg ataatcattg
    10981 cggatacata atgggcataa agctttttct ctgcgtgaat atcagtttgc tgatgcagat
    11041 aaaacgattc cagtgctttg aacatatcag gtatcacatg aggaacaccc cattcccgat
    11101 tgagaaaatg gacaatgggc atatttgaca aagcagaaag cagactggcg agcgccttct
    11161 ccgcttcctt taaggaaaat tcattcgggc tggaggcaat cgtcaggtga tcaatgatct
    11221 ccgcacatga tcgctgtatc atggttcgga gcaattcctc tttattggca tagtgatcat
    11281 aaaaagttgc gcggcggata ttgcttttac gcgtaatatc cgaaatcgtg atgcccgcgt
    11341 agtcttgttt ctccgccaat acgtccagaa atgcctgctg gagcgcctct ctcgttcgaa
    11401 ccacccgcct gtcgattggc ttgcccttct ctcgctctcc tggcacagct tgtccaaaca
    11461 gccaataaaa tctcttttga gaaacaagct cccatacctt ttggctgata gcttccggag
    11521 ccgcggccgc atcctcattc agccaataca ggataattgc gtatgtgtac aaggcccggt
    11581 aatgtccgta aatttctcgt tcgatcggcg tcaaattcac atggatcgga gccagcagca
    11641 catcatggtg aaacacatcc ttaaaaaaac gatggaaatg ccctctgttc atcatcacag
    11701 aaaaaaagga tcgatgctcg tgaacaaagg acagcgtcgg atgcaccgtt tgccgttttt
    11761 tgttcaagtg gagggtatcc aaatgactga aagcatcaaa aagcgcttta cccagccctt
    11821 ccttcatgtc ttcgattaaa tcctcaatga ttgaaaactt atcctcataa taaaggtaga
    11881 gcgtcccacg gctcactttg gccctttcag cgatttcttt cattgtgata tgttgcatat
    11941 ctctttcttc caataaagcc agcagcgcct gtttcacttg agcttcggca gattccggca
    12001 caaaagacac ctccaatcat tagacagttg ttcaatatat gtacggtaac gtatagatgg
    12061 ttcaccgttg tctttcttat aaaaaaggta ccaccttata ataggtccga gaaaagaaga
    12121 aagcaaatga gggggatctt acaatggaac agaaagtaaa ggacgacatc cagcgtgtct
    12181 ttcagcttca gaaaaaacag caaaaagcct tgcgtgcttc aacagcggaa cagcgcaaag
    12241 agaagcttca gcgcttttta gattccgtca tcgcccatga ggaagaaatc attgaagcga
    12301 tccgcaaaga cgtccgcaaa ccatatcacg aggtcaaaaa agcggaaatc gaaggaacga
    12361 aaaaagcgat cagagataat atgaacaacc tggaacaatg gatggcgcct aaggaagtcg
    12421 gttcatcgtt aagccctgag gcaaacggga ttcttatgta cgagcctaaa ggcgtcacac
    12481 tcatcctcgg cccgtggaac tatccgttta tgctgacgat ggcgccgctt gccgcttctc
    12541 tcgcagccgg aaacagcgcg attgtgaagc tgtccgattt cacgatgaac acgagcaaca
    12601 ttgccgctaa agtgataaga gacgcttttg atgaaaaaga agtcgcgatt tttgaaggag
    12661 aggttgaggt ggcaaccgaa ctacttgatc agccgttcga ccatattttc ttcactggaa
    12721 gcacaaatgt cgggaaaatc gtcatgacag cggctgccaa acacttggca tctgtcacac
    12781 ttgagcttgg cggcaagagc ccgacgatta ttgacagtga atacgatctg atggacgcag
    12841 cgaaaaagat cgccgtcggg aaattcgtaa acgccggcca aacctgcatc gcacctgatt
    12901 acctgttcat taaaaaagac gttcaggaca ggtttgcggg gattttacaa acagtcgtca
    12961 acgctggatt tatggaggat gatcataccc cagaccgcag caaatttacg cagatcgtca
    13021 atgaccgcaa cttcaaccgc gtcaaagatc tgttcgacga tgccatcgaa aaaggggcgg
    13081 aagtggtgtt cggcggcgtc tttgatgcca gcgaccgcac gatctcgcca accgttttga
    13141 aaaacgtcac gcctgacatg aaaatcatgc aggaggaaat cttcgcaccg attctgccaa
    13201 tgatgaacta tgaagacatc gacgaggtca ttgattacgt aaatgaccgc gataaaccgc
    13261 ttgcacttta tgtgttcagc aaaaaccaag acatgattga caacgtcctt cagcacacga
    13321 catcaggaaa tgccgccatc aatgatgtcg tcgtccattt cagtgacgtc aacctgccat
    13381 tcggcggcgt caacacaagc ggaatcggct cctatcatgg ggtatacgga ttcaaagagt
    13441 tttctcacga aaagggtgta tttattcaag cctccaaata atcgtaacga agagaatctg
    13501 catcatcttg caggttcttt ttttatcttt atatcaccta aataaagaga ttaaaagtga
    13561 taaaatacca tttttactac gagaccaaac cctgcagccc ctaacgtata atacccagaa
    13621 aactttaaag gagtaaaatg atacatggaa aaaccagcag gattttggat tcgggcagcc
    13681 gcctctatta ttgatgtatt tattatagct atattctctt tcattatgat tttcattaac
    13741 accttcattg tgttgccact cattgatgca gcaggtacac acatgtcaga agcccaatat
    13801 gagtttttca tgttgatcat tggcacaatc cctgttttgg ccatcatatt tattttcgct
    13861 attctttact a
//
