LOCUS       c00080_gnlPro..        12945 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|PPNDKLOK_80.
ACCESSION   c00080_gnlPro..
VERSION     c00080_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-03 18:06:58
            Original ID  :: gnl|Prokka|PPNDKLOK_80
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12945
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12945
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[187:7880]"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [Gly_430_pcre, Gly_8-9_TMA,
                     Gly_radical, Gly_radical_scatole, PFL-like, PFL_6_pcresol,
                     PFL_9_tma, PFL_acetate1, PFL_acetate2, PFL_proline,
                     PFL_toluene]) and not NRDD and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /neighbourhood="10000"
                     /product="GR_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      188..7880
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [Gly_430_pcre, Gly_8-9_TMA,
                     Gly_radical, Gly_radical_scatole, PFL-like, PFL_6_pcresol,
                     PFL_9_tma, PFL_acetate1, PFL_acetate2, PFL_proline,
                     PFL_toluene]) and not NRDD and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /neighbourhood="10000"
                     /product="GR_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..12945
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [Gly_430_pcre, Gly_8-9_TMA,
                     Gly_radical, Gly_radical_scatole, PFL-like, PFL_6_pcresol,
                     PFL_9_tma, PFL_acetate1, PFL_acetate2, PFL_proline,
                     PFL_toluene]) and not NRDD and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /kind="single"
                     /product="GR_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12945
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="GR_AA_metabolism"
                     /region_number="1"
                     /rules="(minimum(1, [Gly_430_pcre, Gly_8-9_TMA,
                     Gly_radical, Gly_radical_scatole, PFL-like, PFL_6_pcresol,
                     PFL_9_tma, PFL_acetate1, PFL_acetate2, PFL_proline,
                     PFL_toluene]) and not NRDD and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(188..1489)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     GR_AA_metabolism: PALP"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg80_1"
                     /sec_met_domain="PALP (E-value: 4.3e-31, bitscore: 97.6,
                     seeds: 146, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYYSTNKQAPLASLEEAVVKGLASDKGLFMPMTIKPLPQEFYDE
                     IENLSFREIAYRVADAFFGEDVPAETLKEIVYDTLNFDVPLVPVKENIYSLELFHGPTL
                     AFKDVGGRFMARLLGYFIRKEGRKQVNVLVATSGDTGSAVANGFLGVEGIHVYVLYPKG
                     KVSEIQEKQFTTLGRNITALEVDGTFDDCQALVKAAFMDQELNEQLLLTSANSINVARF
                     LPQAFYYFYAYAQLKKAGRAENVVICVPSGNFGNITAGLFGKKMGLPVRRFIAANNKND
                     IFYQYLQTGQYNPRPSVATIANAMDVGDPSNFARVLDLYGGSHAAIAAEISGTTYTDEQ
                     IRESVKACWQQTGYLLDPHGACGYRALEEGLQPGETGVFLETAHPAKFLQTVESIIGTE
                     VEIPAKLRAFMKGEKKSLPMTKEFADFKSYLLGK"
     CDS             complement(1636..2847)
                     /locus_tag="ctg80_2"
                     /transl_table=11
                     /translation="MKHIIILGDGMADWAVKSLGDKTLLQYAKTPYMDKLARMGRNGRL
                     ITVADGFHPGSEVANMSVLGYNLPKVYEGRGPLEAASIGVDLQPGEMAMRCNLICTEGD
                     ILKNHSAGHITTEEADVLIQYLQEKLGDDRVRFHTGVQYRHLLVVKGGNKQLDCTPPHD
                     VPLKPFRPLMVKPLVPEAEETASLLNELILKSQELLKDHPLNLKRMAEGKDPANSIWPW
                     SPGYRPQMERLSDTFPQVKRGAVISAVDLINGIGYYAGLRRIAVEGATGLYDTNYENKV
                     AAALEALKTDDFVYLHIEASDEAGHEGDVALKLKTIENLDSRAVGPIYEAVKEWEEPVA
                     IAVLPDHPTPCELRTHTNEPVPFFIWYPGIEPDSVQTFDEVAAVEGSYGLLKEDEFIKE
                     FMNR"
     CDS             complement(2859..4805)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     GR_AA_metabolism: Homoserine_dh"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg80_3"
                     /sec_met_domain="Homoserine_dh (E-value: 1.2e-51, bitscore:
                     164.3, seeds: 932, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINAQDIKNGTCIRMDGKLYFCIEFLHVKPGKGNTFMRTKLKDVV
                     SGYVLERRFNIGEKLEDLRVERRPYQYLYKEGEDYIFMNQETFDQHPIAHDLINGXYPV
                     CHKNIPILIKNTFNPDAQGTVIKQHVDHTKSKAIKGISSINDTSLITVQGLGMVGVIGV
                     NYRIFKALAKNGISVFLVSQASSENSTSIGVRNADADLACEVLNEEFAKEIEMGEISPI
                     QAEKNLATVAIVGENMKHTPGIAGKLFGTLGRNGINVIACAQGASETNISFVVDSKSLR
                     KSLNVIHDSFFLSEYQVLNLFICGVGTVGGSLVEQIRQQQKKLMVENGLKLHVVGIIDA
                     TKAMFSRAGFDLANYREELKEKGVDSSLDTIRDEIIGMNIFNSVFVDCTASPDIASLYK
                     DFLQHNISVVAANKIAASSAYENYRELKLIARQRGVKYLFETNVGAGLPIINTINDLIH
                     SGDKILKIEAVLSGTLNYIFNKISADVPFSRTIKMAQEERYSEPDPRIDLSGKDVIRKL
                     VILAREAGYKLEQEDVEKNLFVPNDFFEGSLEDFWKKVPSLDADFEARRKVLESENKHW
                     RFVAKLENGKASVGLQEVDRNHPFYGLEGSNNIILLTTERYKEYPMMIQGYGAGAGVTA
                     AGVFADIMSIANV"
     CDS             4999..5160
                     /locus_tag="ctg80_4"
                     /transl_table=11
                     /translation="MKRTFQPSNRKRKNKHGFRERMATANGRRVLAARRAKGRKKLTVS
                     DEYNGVKA"
     CDS             5372..6013
                     /locus_tag="ctg80_5"
                     /transl_table=11
                     /translation="MTIKEFFSFKANRFFWINIIAMVVVAVLIVVGTLKGLDIYTRHGE
                     AVIVPDVKGMSVSEAEKMFRNHGLTCVVSDSSYVKNKPSGIILDLNPSVGQKVKEGRTI
                     YLTINTLSTPLSVVPDVADNSSVRQAQAKLIAAGFKLTENRMVSGEKDWVYGVIYQGRQ
                     LQIGDKAPIGATLTLMVGDGVQSTATDSVDMVENAAMSVEDSGTDDDSWF"
     CDS             6043..6243
                     /locus_tag="ctg80_6"
                     /transl_table=11
                     /translation="MIEELPDDIEQDELDDIEPVGDENQLYEHFRVVVDKGQAMVRVDK
                     YLFERIVNASRNRIXPYPAAE"
     CDS             complement(6225..7880)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     GR_AA_metabolism: PFL-like"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg80_7"
                     /sec_met_domain="PFL-like (E-value: 1.4e-92, bitscore:
                     300.5, seeds: 123, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNERINYLKTYILDKRHHSQRRAPSSIGLDKLNTIYAQQGLSPVE
                     RATACFAALMNAELPVILPGEKIVFTRTLTQVPDIYTPEEWNEIKNKYYIHEKGTVCNI
                     SPNYAYTIQHGLEARKQEIRKRQENPSLNEKERVFLNSMYQCIISIQKLIEKYEQYALL
                     NNETEIAHTLHTIKTEGAQNFRQALQLLRILHFSIWEAGNYHNTLGRFDQYMYPFYQRD
                     LENGTLTKEEAFDLLEEFFLVCNKDSDLYPGMQQGDNGQSLVLGGRDPEGKYLFNDLSR
                     MCLQASYELKLIDPKINIRVDPKTPDEIFTLGSRLTKIGLGFPQYSNDDIIIPGLIRKG
                     YSKEDAYNYVVAACWEFIIPNRAMDIPNIDAVSLIGCVDRCLEKLNTCSDYSSFYTLVE
                     QEIQKEVNAICEKHRNLYIIPSPMMSLLMDGTIERAKDISEGSYYNNYGIHGTGIATAT
                     DTLAALKKYYFEEQSLDYTTLLTAIRSNFKGYEELQKKLREEAPKMGQDNDYADLIAKD
                     LLDSFDRSLADKRNERGGVYRAGXXXIXYYSAAG"
     CDS             complement(7877..8662)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Radical_SAM"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg80_8"
                     /sec_met_domain="Radical_SAM (E-value: 1.9e-29, bitscore:
                     92.4, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYIFAIVNPNTMKTGTIFSVEEFAIHDGPGIRTTIFLKGCPLRCA
                     WCHNPEGISPQPQYMIKKGVKSICGYQITVEELVTMIEKNRSIYTLNRGGVTLTGGEPL
                     FQPDFVIELLRQLPDIHTAIETSGYANTHIFNEVTSLADLILFDIKHTDPEMHRKYTGV
                     DNAIILENLALLCNSGRDFIIRIPLIPGVNDTRENMSAILEKIKDARNLIRVEILRYHR
                     TAGAKYAMIGETYHPPFDTGKAPQIYNVFEENNIKNLIV"
     CDS             complement(8861..12943)
                     /locus_tag="ctg80_9"
                     /transl_table=11
                     /translation="LFDSFLFQTFVLYVIKRRMKKSTFTLILFFSSVILYAQQNELMFH
                     SLGSQHGLTYSAVRDILQDSKGYIWIATLKGLNRYDGYNIKQYYKSDDGLSSNCIEKLL
                     LLGQDTLLMGTNEGLCLYDMMREKFTTIVPQTKAPLYVLDMAYDGRSVFIASDSGLYAY
                     SKTEQSMPLLHKGLIVKVTLDMNGNVWAVSPNTIYCFRPNGQMTRKITATEVSPDYPVE
                     FTSIYKDSQGTLWLGTTENGLYRYNKNYNQFVSVEFASQDRKDMRYIRCIQEDMRGNLW
                     IGTENGLFIYDYTDNSYIQYRQHAKDVQSGLTDNAIYTIYKSRGDIMWIGTFFGGVSYT
                     SLTENNFHYLIADNGKQYLKGKAISNIIKDKNGALWFASEDHGISILYPDGHIRYLNKS
                     THPSLNGDNVHALAEDHSGNIWIGNFIDGLQKVDLAKGYIRSYKNIAGGHAGLSNNSIY
                     KLYVHNPDTMFIGTSQGVNIYHFRTDSFTPFLPDVFRLIRIDDITRDLKGNIWFSTHFN
                     GIFRYHIPTHSIHRYQKGVTGCKTMASDNIYCSFVDSKGEVWFGTSNGGLMKYNAHADS
                     IQAFGKENELRQRDIYSIQEDSFGYLWMSTDNGIFSFNPESRSFAHYKVSDNLVSNQFN
                     ACPGYKDPDGTLFFGSINGVCFFRPEGLNHNSPTNDIHLTFSDFRIFNKHVQPSPDGIL
                     QNNIDSTSVIRLPHGMNTLTFDFLVINYNENCQSQLSCEYYLEGMETEWNATQQIPQSV
                     TYTNLDPGTYQFHVRVIGKNGVVFDRRKITINIRPHFLLSGFMITIYSLIGLLISFIIV
                     RFYQVRMRDKMDIRIERMEKNNLRELNKHKLNFFTYITHEFKTPLSILMAVFEDISIGR
                     NNTITGEEMKIINRNIQRLQFLINQLLEFRSVETDHARIEYVKGDIMTYGRSIFELFIP
                     VFRQKQIVFQYATSADSYYTVFDRDKIEKIISNLLSNAFKHSDPQSEINFRIDVDKASG
                     QLILSCHNSSSYIHPEQREAVMQPFHKTDSSDQKYSNTGIGLALVNGLVQLLSGTVEIE
                     SHQNSGTTFKVKLPLVEDSKDMIAPDETLDIVNSPDVVADTVYLLNNSGLKEDMNAANA
                     EKKMTVLLVEDNPDINNILKSKLLRLYKVKTAYNGQEAVELLKTHIIDIIISDIMMPYM
                     DGYELSKYIKTSREYSHIPVILITSQPSKENELQGLSAGADAYIEKPFTFDELNLRITN
                     LLKAKNNIREHYHDMKIFQLNEELNNKDEEFIKSLTQFVIEHIENPELSVDQLTTHMNI
                     SRTQLYNKLKKLLNLSATEFINKIKIDVAKVKIIKTNLTIAEISWQLGFNNPSYFSKTF
                     KRFCGVTPNEFKNGKSQ"
ORIGIN
        1 cgccactccc ccccagaagt atctctgaga ccgttttcac aaacaatttc ccgtcagcat
       61 ctccatccgg gaaaagagcc gccggctgtg ggaaaagcat atttcaccat agaaagcgca
      121 aagcattcac attaataatc cataacaaaa gtcatctaca tcaccctgtg ccctcaaggg
      181 agagtctcta cttgcccagc agatagctct tgaaatcagc aaactccttc gtcatcggca
      241 aacttttctt ttcgcctttc ataaaagccc ggagcttagc aggtatttcg acctcggtac
      301 caatgatgct ctccaccgtt tgcaggaatt tggccggatg ggccgtttcg aggaatacgc
      361 ctgtctcacc cggctgcaag ccttcctcca atgcacggta accgcatgct ccatgaggat
      421 cgagcagata acccgtctgc tgccagcacg ctttcacgct ttcacgaatc tgctcgtcgg
      481 tgtacgtcgt tccggatatc tcggcagcga tggctgcatg cgaaccgcca tacaggtcga
      541 gcacacgggc aaagttgctc ggatcaccca catccatcgc attggcaatg gtggcaacgg
      601 acggacgggg attgtactgt cctgtctgca aatattgata gaaaatatca ttcttattgt
      661 tggcggcgat aaaacggcgg acgggcaagc ccatcttttt gccgaacaag cctgcagtaa
      721 tgttaccaaa gtttccgctc ggcacacaga tgacgacatt ctctgcccgg ccggccttct
      781 tcaattgcgc ataggcataa aaataataga atgcctgcgg caggaaacgt gccacgttga
      841 tagagttagc cgaggtcagc aacaactgtt cgttcagttc ctgatccata aaggctgctt
      901 tcaccagcgc ctggcagtca tcaaacgttc cgtccacctc cagggctgta atattccgcc
      961 ccagcgtagt gaactgtttt tcctgtatct cgctgacttt tcccttcgga tagagcacat
     1021 acacatgaat accctctacc cccaaaaagc cattggctac cgcactaccg gtatctccgg
     1081 aagtggcaac gagcacattc acctgtttcc gcccctcttt ccggatgaag tatcccaaca
     1141 aacgggccat aaaccgtcca cctacatctt taaaagccaa tgtaggaccg tggaaaagct
     1201 ccagggaata gatgttctcc ttcaccggca ccaacgggac atcaaaattc aacgtatcat
     1261 aaacgatctc tttcagcgtt tccgccggaa catcttctcc aaagaaagca tctgccaccc
     1321 ggtaagcgat ttcccggaaa gaaagattct ctatctcgtc ataaaactct tgaggcaagg
     1381 gcttgatggt catgggcatg aatagcccct tatcagaagc aagtcctttg actaccgctt
     1441 cttcaagcga agcaagcgga gcttgtttgt tagtactata atatttcatg ggtattttta
     1501 taaatggttt cggagtcggt gcaccacaga ttacacggat tttcacagaa ctttcaatct
     1561 ttttatcaat aaaaataaat cattcatctg tgaaaatccg tgtaatctgt ggtgaacaaa
     1621 ctctgttcct attccttaac ggttcataaa ctctttaata aattcatcct ctttcagcaa
     1681 tccgtaactg ccctccactg ctgcaacttc atcgaaggtc tgcacgctgt ccggctcgat
     1741 acccggatac cagataaaaa acgggaccgg ctcgttggta tgcgtacgca gttcgcaggg
     1801 agtaggatga tcgggtaata cggcaatcgc taccggctct tcccactcct tcacagcctc
     1861 gtagatagga cctacggcac ggctatccag gttttcaatc gttttcagtt tcagcgccac
     1921 atcaccctca tgaccggctt cgtcactggc ttcaatgtgc agatagacaa agtcgtccgt
     1981 tttcagggcc tccagtgcgg cggccacttt attctcgtaa ttggtatcgt acagccccgt
     2041 tgccccttct accgcaatac ggcgcagccc ggcataatat ccgataccgt tgatcagatc
     2101 gacggccgag atgacagctc ccctcttcac ttgcgggaag gtgtcggaca gacgttccat
     2161 ttgcggacgg taacccgggc tccacggcca gatgctgttg gcagggtctt tcccctcagc
     2221 catccgcttc aggttcagcg gatgatcttt cagcagttcc tgagacttca ggatcagttc
     2281 attgagcagg ctagcagtct cttcggcctc cggtaccaaa ggtttcacca tcagcggacg
     2341 gaaaggcttc aaaggcacat cgtgcggagg ggtgcagtcg agttgcttgt ttccgccttt
     2401 caccaccagc agatggcggt attgcacccc ggtatgaaac ctcacccggt cgtcccccag
     2461 tttctcctga aggtattgaa tcaacacatc cgcctcttct gttgtgatat gccctgccga
     2521 atgattcttc aggatatctc cttccgtaca aatcagattg caacgcattg ccatctcgcc
     2581 cggctgcaaa tcgacaccga tgctggcagc ctcgagtggt ccgcgccctt cgtatacttt
     2641 cggaagattg tatcccagaa ccgacatatt ggctacttca cttcccggat ggaacccgtc
     2701 ggctacggtt atcaaccgtc cgttccgtcc catacgggcc agtttatcca tataaggcgt
     2761 ttttgcatat tgcaggagcg tcttgtctcc caacgacttt acagcccagt cggccattcc
     2821 gtcacccagt atgatgatgt gtttcataag cttctttttt atacgtttgc aatgctcata
     2881 atgtcagcaa atacaccggc cgccgtcact ccggcacccg caccgtatcc ctgaatcatc
     2941 atcggatatt ctttatagcg ttcggtggtg agcaagatga tgttattgct gccttccagt
     3001 ccgtagaaag gatggttgcg gtccacttcc tgcaaaccga cggatgcttt gccgttctcc
     3061 agcttggcaa cgaaacgcca atgtttattc tcactctcga gcaccttgcg gcgagcttcg
     3121 aaatcagcat ccagactagg cacttttttc cagaagtctt ccagcgaacc ttcaaagaag
     3181 tcattcggta cgaaaagatt cttctccacg tcttcctgtt ccagcttgta tccggcctca
     3241 cgcgccagga tcacgagctt acggatcacg tccttaccgc tcaggtcgat gcgcggatcg
     3301 ggttccgaat aacgctcttc ctgcgccatc ttgatggtac ggctgaaggg aacatcggca
     3361 ctgatcttat tgaaaatata gttcagcgta cccgaaagca ctgcctcgat cttcagaatc
     3421 ttatcaccgc tatgtatcag gtcattgatg gtattgataa tcggaagtcc ggcccccacg
     3481 ttggtttcaa acagatattt cacaccacgc tggcgggcta tcagcttcag ttcacggtaa
     3541 ttctcgtaag ccgatgaagc agcaatctta ttggccgcca ccacagaaat gttatgttgc
     3601 aggaagtcct tatatagaga ggcaatgtcc ggactggccg tacaatccac aaataccgaa
     3661 ttgaatatat tcatgccgat aatctcgtca cgtatagtat ccagcgaact gtccactccc
     3721 ttctctttca gctcttcgcg atagttggcc agatcgaatc cggcacggct gaacatcgcc
     3781 ttcgtcgcat cgataatacc taccacatgg agtttcaggc cattttctac catcagcttc
     3841 ttctgctgct ggcggatctg ctcgacaaga cttcctccca ccgtgcccac accgcagata
     3901 aagaggttga gcacctgata ttcggagagg aagaacgagt cgtgaatcac attcagcgat
     3961 ttacgcaacg actttgaatc gacaacaaac gagatgttgg tctcggaagc tccctgtgca
     4021 caggctatca cattgatgcc atttcgtccc agcgtaccga acagctttcc ggcaatgccc
     4081 ggcgtatgtt tcatgttctc acccacgata gctaccgtag ccaggttctt ctctgcctgg
     4141 ataggcgaaa tctcacccat ttcgatctct ttggcaaact cttcgttcag cacttcgcaa
     4201 gccagatcgg catcggcatt acgcacaccg atagaggtac tgttctccga tgaagcctgc
     4261 gaaacgagga acacactgat tccattcttt gccagcgcct taaagatgcg gtagttgaca
     4321 ccgatcacgc ccaccatacc taaaccctgt acggtaatca ggctcgtgtc gttgatggac
     4381 gaaatccctt tgatggcttt gctcttcgtg tggtctacgt gttgtttgat caccgttccc
     4441 tgggcatccg ggttgaaagt attcttaatc aggatcggta tgtttttgtg acataccgga
     4501 taganaccgt tgatcaggtc gtgagcgatc gggtgttgat cgaatgtttc ctgattcatg
     4561 aagatataat cttcaccttc tttgtacagg tactgatagg gacgacgttc aacgcgtaag
     4621 tcttccagct tctcaccgat attgaagcga cgttcgagaa cgtagccgct tactacatct
     4681 ttcagttttg tacgcatgaa ggtgttacct ttacccggtt taacgtggag gaattcgata
     4741 cagaaataca gtttgccatc catgcggata caagttccgt tcttgatgtc ttgagcatta
     4801 atcatacttg atattcttta ttttatagat tgttattgag ttatcttcga accttttcgg
     4861 gtgcaaaagt aatctaaatc ggcaaaaaac acaaaatgtt ttgactaaaa atgacttaac
     4921 tcttggttta tttaaaaaaa gtgcctattt ttgcagcccg aatccgtaga agtaataaca
     4981 taaaaacaag atacagtaat gaaaagaaca tttcaaccct ctaacagaaa gagaaaaaac
     5041 aaacacggtt tccgtgagag aatggctaca gctaacggcc gtagagtatt ggctgcacgt
     5101 cgcgctaaag gtcgtaagaa actgactgtt tctgacgaat acaacggagt gaaggcataa
     5161 gtattagcca ttgcaaacga ataagaagaa gtgaaggagg attcctttgc ttctttttgt
     5221 tttagaaccg gttccaattt gattacggta tcaggcgcaa ggtggaaaac caaaagagag
     5281 ggttttgata cgctttttta aaaactcggt gaaagtctgt gatactgtgt aacgaaaata
     5341 gtatctttgt ccgcattaac agcttataat tatgacgata aaagaatttt tttctttcaa
     5401 ggccaataga ttcttctgga taaacatcat agccatggtt gtagtggctg tgctcatagt
     5461 ggttggcaca cttaaaggac tggatatata cacacgccat ggcgaagctg taatagtgcc
     5521 cgacgtaaaa ggaatgtctg taagcgaagc ggaaaagatg ttccggaatc atggactgac
     5581 ttgtgtggtg tccgactcca gttacgtaaa aaataaacct tccggcatta tcctggatct
     5641 taacccgtcg gtcgggcaga aagtgaaaga aggacgaaca atctatctga caataaatac
     5701 cctcagtact cctttgagtg tggtgcctga tgtggccgat aacagttccg tgcgtcaggc
     5761 gcaggcaaag ttgatcgccg caggctttaa acttaccgaa aaccggatgg tgagcggaga
     5821 gaaggactgg gtatatggcg tgatctatca gggacgccaa ttgcagattg gagataaagc
     5881 tcccatcggc gctacgctga ctctgatggt aggtgacgga gtgcagtcta ccgcaaccga
     5941 ttctgtcgat atggtggaaa atgctgctat gtctgttgag gattccggaa cagatgatga
     6001 ttcctggttt taatataaga aacgtatacg tagaaaaaac gcatgataga agaattgcct
     6061 gacgatattg aacaggacga attggatgat atagaacccg taggtgacga aaaccagctc
     6121 tatgaacatt tccgcgtggt agtggataaa gggcaggcaa tggtcagggt cgataaatat
     6181 ttgtttgaac gcatcgtcaa tgcttcgcgc aatcgcatan aaccctatcc cgcagcagag
     6241 tagtannnaa tgntanncnn acctgcccgg taaacacctc cgcgttcatt tcgtttatcg
     6301 gccaatgacc gatcaaaaga gtcgagaaga tctttggcta tcaagtcggc atagtcatta
     6361 tcctgtccca ttttgggcgc ttcttctctt aatttttttt gtaactcttc gtagcctttg
     6421 aagttgcttc ttatggcagt aagcagggtt gtataatcca ggctttgctc ttcgaaatag
     6481 tattttttca gggcagcaag ggtatcggta gcggttgcaa tgcctgttcc gtggattccg
     6541 tagttgttgt agtaggaacc ttccgaaata tctttggctc tttcgatggt gccgtccatc
     6601 agtaaagaca tcattggaga agggatgatg tagagattgc ggtgtttctc gcagatcgca
     6661 ttgacctcct tttgtatttc ctgctccacc aatgtataaa aggatgaata gtccgaacag
     6721 gtatttagtt tttcaaggca ccggtctaca catccgatta aagaaacggc atcaatgtta
     6781 ggtatatcca tggctcggtt agggatgata aattcccagc aggcagccac tacgtaattg
     6841 tatgcgtctt ctttggaata gcctttccgt ataagtcccg gaatgatgat atcatcattg
     6901 ctgtattggg ggaaacccag ccctattttg gtcagacggg aacctaaagt gaatatttcg
     6961 tcaggggtct ttgggtctac acgaatgttg attttaggat caattagttt taattcgtaa
     7021 cttgcctgca ggcacatgcg ggacaggtcg ttgaataagt atttgccctc cggatcgcgt
     7081 cctcccaaaa ccaggctctg cccattgtca ccctgttgca tacctggata caggtcgctg
     7141 tccttattgc atacaaggaa aaattcttca agcagatcga atgcttcttc tttggtgagt
     7201 gttccatttt ccaggtccct ctgatagaaa ggatacatat attgatcgaa gcggccgagg
     7261 gtattgtgat agttgcctgc ttcccaaata gagaaatgga gaattctcaa aagctgtaga
     7321 gcttgtctga agttttgagc gccttcggtc tttatggtat gtaaagtgtg cgcaatttct
     7381 gtctcgttat tgagcaatgc atattgttca tacttctcaa ttagtttctg tatggatatg
     7441 atgcattggt acatgctatt gaggaatact ctctcttttt catttaagga gggattttcc
     7501 tgacgctttc ggatctcctg ttttctcgct tccagtccgt gttgaatggt ataagcgtaa
     7561 ttgggggaga tattacatac cgtacctttt tcgtggatgt aatatttgtt ttttatttcg
     7621 ttccattctt caggggtgta tatatccggt acttgcgtaa gggtacgggt aaaaacgatc
     7681 ttttcacccg gaagtataac cgggagttca gcgttcatca aagctgcgaa acaggctgta
     7741 gcacgttcta caggagataa accttgttgg gcataaattg tgttcaattt gtccagcccg
     7801 atacttgacg gtgctctcct ttgtgaatgg tgtcgtttat ctaaaatata cgtttttaga
     7861 tagttaattc tttcgttcat acaattagat ttttgatatt attttcttca aatacattat
     7921 agatttgtgg cgcctttccg gtatcgaacg gaggatgata cgtttctccg atcattgcgt
     7981 atttggcacc tgctgtacgg tgatatctaa ggatttcgac acgtatcagg ttcctggcat
     8041 ctttgatttt ttcaagaatg gcactcatgt tttcccgggt atcattaaca cccgggatta
     8101 aaggtatccg aatgataaaa tctcgtccgg aattacagag taaagcaaga ttttccagta
     8161 taatcgcatt atccactcct gtatatttcc ggtgcatttc cgggtccgta tgtttgatgt
     8221 cgaataaaat aagatcagct aaagaagtaa cctcattgaa aatgtgagtg tttgcgtatc
     8281 cgcttgtttc gatagccgta tgtatgtccg gaagttgtcg gagcagttcg ataacaaaat
     8341 ccggttgaaa taagggttct ccgccggtta gtgtaactcc tccccggttg agcgtataaa
     8401 tggaccggtt cttttcgatc atggtaacca attcttccac agttatctga tatccacaaa
     8461 tacttttaac tcctttttta atcatgtatt gcggctgtgg cgatatacct tcgggattat
     8521 ggcaccatgc acagcgtaga ggacatccct tgagaaatat cgttgttcgg attcccggtc
     8581 cgtcatggat ggcaaattcc tcgacactga atattgttcc tgttttcatt gtgtttggat
     8641 taacaatggc aaatatatac ataatatttt aaacaggtac gaactggtat gtatgttgtt
     8701 gagcatatat tcatataata ttaagaatat taatagctca aattaccttt ataggtaatg
     8761 tttatgggag taaagacgat tattcgacat ttacaaataa tggatgtctc agatcactgt
     8821 taaggcgtaa tggaccgaat aaaatggcaa aacggtctgt ctattggctt ttaccgtttt
     8881 taaattcatt aggtgtcact ccacaaaaac gcttgaatgt cttactgaaa tagctgggat
     8941 tattgaatcc gagttgccat gagatttcag caatagtcag attagtcttt ataatcttta
     9001 ctttagcaac atcgatcttg attttattga taaactcggt tgcactcagg tttaatagtt
     9061 ttttcagttt attgtatagt tgagttcgac tgatattcat gtgagtggtc agttggtcga
     9121 cactcaattc cgggttctca atgtgttcga tgacgaattg tgtcaatgat ttgataaatt
     9181 cctcgtcttt gttgttgagt tcttcattga gttggaatat tttcatgtcg tgataatgtt
     9241 cgcggatatt atttttggct ttaagcaagt tggtaattct aagattcaat tcatcgaaag
     9301 tgaatggttt ttcgatatag gcgtcggctc ctgcagataa accttgcaat tcgttttctt
     9361 tcgaaggctg tgaagtgatg agaatgaccg ggatatggga gtactcacga gaagttttaa
     9421 tatatttact caattcatat ccgtccatat aaggcatcat aatgtcactg atgataatgt
     9481 cgatgatatg tgtttttagc aactctacag cttcctgtcc gttataagcc gttttcacct
     9541 tatataaacg gagtagctta ctttttaaaa tgttattgat atccggatta tcttccacca
     9601 aaagtacagt catctttttc tcggcatttg cagcattcat atcctctttt agtccggagt
     9661 tattgagcag gtatacagta tctgccacta cgtcgggtga gttaacgata tccaaagttt
     9721 cgtccggtgc aatcatatcc ttagagtctt cgaccaaagg taattttact ttaaaggtcg
     9781 taccgctgtt ttgatgactt tctatctcaa ctgttcctga aagcagctga actagaccat
     9841 tcaccaaagc cagtccaata cccgtattgg aatacttttg atcggatgaa tcggttttgt
     9901 gaaaaggctg catgacagct tcccgctgtt ccggatgaat atatgaactg ctgttatgac
     9961 aggagagaat caattgtccg gaagctttgt ctacatcaat cctgaagttt atttcacttt
    10021 gaggatcaga atgtttgaaa gcattactga gcagattact gatgattttc tctatcttgt
    10081 ctctatcgaa taccgtataa taagagtcgg ctgaagttgc atattgaaaa acaatctgct
    10141 tttgtctgaa gacgggaata aacagttcga agatgctgcg tccataagtc ataatatctc
    10201 ctttgacata ttcgatgcgt gcatggtcgg tttctacaga gcgaaattcc aaaagttgat
    10261 tgatcaggaa ttgaagccgt tggatattcc gattgatgat tttcatttct tcaccggtaa
    10321 ttgtattgtt tcgtccgatt gatatatctt cgaatacagc cataaggata gataaaggag
    10381 tcttaaactc atgggtgata taagtgaaaa aattcagctt gtgtttattc agttcgcgca
    10441 ggttgttttt ttccattctt tcgatgcgga tatccatttt gtctcgcata cgcacttggt
    10501 agaagcggac aattataaaa ctgataagaa gtccgataag agaataaata gtgatcatga
    10561 aaccactcag caaaaagtga ggacgaatgt taatggttat tttccgacgg tcgaatacaa
    10621 ctccgttttt tcctatgacc cgtacgtgaa attggtaggt gcccggatca aggttggtat
    10681 atgtgactga ttgtgggatt tgttgtgttg cattccattc ggtctccata ccttccagat
    10741 agtattcaca ggaaagttgt gattggcaat tttcattata gttgattacc agaaaatcaa
    10801 aagtcagggt attcataccg tgaggtaagc gaatgacaga tgtgctgtcg atattattct
    10861 gtagaatgcc gtctggtgat ggttgtacgt gtttattaaa aatcctgaaa tccgagaaag
    10921 tcagatgaat atcgtttgta ggactgttat ggttcagtcc ttccggtcgg aagaagcata
    10981 ccccattgat actgccaaag aaaagggtac cgtcaggatc tttatagccc ggacaggcat
    11041 tgaactggtt ggaaaccaga ttatcggata ctttataatg ggcaaaactc cgactttccg
    11101 gattgaaaga gaagataccg ttatccgtac tcatccataa atagccaaag ctatcttcct
    11161 gtatggaata aatatctctt tggcggagtt cattctcctt tccgaacgcc tgtatactgt
    11221 ctgcatgtgc attgtatttc atcaatcctc cgttgctggt accgaaccag acctctcctt
    11281 tggagtcaac aaaactacaa taaatattat cgctggccat tgttttacag cctgtcactc
    11341 ctttttgata tcgatggata ctatgggtcg gaatatgata ccgaaaaata ccgttgaaat
    11401 gtgtggaaaa ccagatattt cctttgagat cacgtgtgat gtcgtcaata cgtataagcc
    11461 ggaatacatc cggaaggaag ggagtgaatg aatcggtccg gaaatgatag atattgacac
    11521 cttggctggt tcctataaac atagtatcag gattatgaac ataaagttta tagattgaat
    11581 tattggatag tcccgcgtgt ccccctgcta tgtttttata tgaacgaata tagccttttg
    11641 ctaaatcgac tttttgcaac ccatcgataa agttgccaat ccagatatta ccggagtgat
    11701 cttcggctaa tgcatggaca ttatctccgt ttaatgacgg gtgtgtcgat ttgtttaaat
    11761 acctgatgtg accatccggg taaagaatag aaattccatg atcttcggat gcaaaccaca
    11821 aagctccgtt tttatcttta atgatgttgc tgattgcttt tcctttcagg tattgtttcc
    11881 cattatctgc tatcaggtag tggaaattat tttcggtcag gctggtgtaa ctgacccctc
    11941 cgaagaaagt gccgatccac ataatgtcac cccggctttt ataaatagta tagatcgcat
    12001 tatcggtcag tccggattgg acatcttttg catgctgccg atattgtatg tagctgttat
    12061 ctgtatagtc atagatgaaa agtccgtttt cggttccgat ccataaattt ccacgcatat
    12121 cttcttggat gcagcgaata taacgcatat cctttctgtc ttgtgaagcg aactccacgg
    12181 atacgaattg attatagttc ttgttgtatc ggtacagtcc gttttcggtc gttcccagcc
    12241 atagagtccc ctgcgaatct ttataaatag aagtaaactc gacaggataa tccggagaaa
    12301 cctcagtagc tgtgattttt ctggtcattt gtccgtttgg gcggaaacaa taaatcgtat
    12361 ttggactcac tgcccataca tttccattca tatccagcgt tacttttaca atcaatccct
    12421 tatggagtag tggcatactt tgctctgtct tactatatgc atatagcccg gaatcggacg
    12481 caatgaaaac tgaacgtccg tcgtaggcca tgtccaatac atatagtggg gccttggttt
    12541 gcggaacaat agtggtgaac ttctctctca tcatatcata caagcacagt ccttcattgg
    12601 tacccatcaa tagagtatcc tgaccgagga gtagcagttt ctcgatgcag tttgaagaga
    12661 gtccgtcatc tgacttataa tattgtttga tgttgtatcc atcatacctg ttcagtcctt
    12721 tgagggttgc aatccaaata tatccttttg aatcctgcag aatatcccgt acggcactat
    12781 aggtaagtcc gtgttgacta cccagggagt ggaacataag ttcattctgt tgtgcatata
    12841 ggataacaga agaaaaaaat aaaatcaggg taaaagtgct cttcttcatt cgtctcttaa
    12901 ttacgtacaa cacaaaagtc tgaaataaaa acgaatcaaa aagat
//
