LOCUS       c00488_gnlPro..        13970 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|PPNDKLOK_495.
ACCESSION   c00488_gnlPro..
VERSION     c00488_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-03 18:06:58
            Original ID  :: gnl|Prokka|PPNDKLOK_495
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 1209
            Orig. end    :: 15179
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13970
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[11209:14957]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..13748
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..13970
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13970
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             435..806
                     /locus_tag="ctg488_4"
                     /transl_table=11
                     /translation="MTLATNIANQSRRGYRDSSMNRDELIWNAQLAQSLLKGAATVSFE
                     VYDILRQQSNISRSLSADMRSVSEYNGINSYCMVHFIYRLNIFGSKAAREKMMNSGRRG
                     FGGPGRGPGGGFGGGHPRF"
     CDS             969..2408
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PLDc_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg488_5"
                     /sec_met_domain="PLDc_2 (E-value: 1.8e-27, bitscore: 86.0,
                     seeds: 83, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIDWNYIASVIATVAFDIIYFGAIIGTIVIVILDNRNPVKTMAWI
                     LILMFLPVVGLVFYFFFGRSQRREKIIGKKSYDRLLKKPMAEYLAQNCCETPKEYARLI
                     QLFQNTNQAFPFEGNRVDIYTGGYSKLQALLRELQKARLHIHMEYYIFEDDPVGRLVRD
                     VLIEKAREGVEVRVIYDDVGCWHVPHRFFEEMRDAGIEVRGFLKVRFPLFTSKVNYRNH
                     RKIVVIDGRIGFIGGMNLAERYMRGFSWGIWRDTHILLEGKAVHGLQTAFLLDWYFVDR
                     TLITASRYFPKIEAYGNSLVQIVTSEPIGPWKEIMQGLTVAISGAKKYFYMQTPYFLPT
                     EQILGAMQTAALAGVDIRLMLPEHADNRVTHLGSCSYLADVLRAGVKVYFYKKGFLHSK
                     LMVSDDMLSTVGSTNLDFRSFEHNFEVNAFMYDMETALQMREIFLQDQRESTQIFLKSW
                     EKRSSRQKAMESVVRLLAPLL"
     CDS             complement(2426..2917)
                     /locus_tag="ctg488_6"
                     /transl_table=11
                     /translation="VPRTFKARPTTDFAKENLFNVLSNYIDFEEGIVALDLFAGTGSIS
                     IELVSRGCDRVISVEKDGAHHAFISKIMKEVQTDKCLPIRGDVFKFINGSHERFDFIFA
                     DPPYELKELETIPDLIFKNNLLKEDGLFVLEHGKKNNFEDHPHFIERRVYGSVNFSFFR
                     "
     CDS             complement(2950..3744)
                     /locus_tag="ctg488_7"
                     /transl_table=11
                     /translation="MPDRAIAETIDFGKSEQYTLSIRLSTDGFSFSIYNPIHDSSLSFF
                     EKEVEASLSLTANLKQAFRELDFLNHTYKRVNILMADKRFTLIPLELFEDDQSEMIFYH
                     NHTPKENETVKYNILKKNNAVVIFGMDKSTCQFLSDQYPEARFYSQAAPLAEYFSAKSR
                     LGNSKKIYASIRRDAIDFFCYERGHLLLANSFECRKTGDRIYYLLYLWKQLNFDQERDE
                     LHLTGAFNDKEKLMQELRKYIQQVFIMNPASNIDMQALLTCE"
     CDS             complement(3752..4435)
                     /locus_tag="ctg488_8"
                     /transl_table=11
                     /translation="MKTVFNIVLGVCAIALVYICYASIMGPINFEKAKKHRDKAVVARL
                     IDIRKAQAEYRNIYKQYTASFDTLIDFVKTQKIPFVSKEGVLSDKQLEDGMTEKKAMAL
                     INKAKKTNNWKEVEAAGLMGFKRDTIWVAVTDTIYDKSFNADSLRYVPFGNGAQFEMYT
                     KNDTTKSGAPIFLFQANTPYDVYLNGLDKQEIANLKDLQVKLGKYAGLMVGSIDTPNNG
                     AGNWE"
     CDS             4532..5950
                     /locus_tag="ctg488_9"
                     /transl_table=11
                     /translation="MINNYLERQIKENFSYQPTFEQEIAVKSLSEFLLSTANDTVFVLR
                     GYAGTGKTSLVGALVKAMDKLQQKSVLLAPTGRAAKVFSAYAGHPAFTIHKKIYRQQSF
                     SNEVSNFSINDNLTTHTLYIVDEASMISNEGLSGSMFGTGRLLDDLVEFVYSGAGCRLL
                     LMGDTAQLPPVGEEQSPALATEALKGYGLNVIEVDLTQVVRQVQSSGILWNATQIRQLI
                     AEDECFSLPKIKVSGFPDIQVVRGDELIDTLTGCYEKDGMDETIVVCRSNKRANIYNKG
                     IRAQILYREDELNTGDLLMVAKNNYFWTEKYKEIDFIANGEIAVVRRVRRTRELYGFRF
                     AEVLLAFPDQNDFELEANLLLDTLHSDAPALPKTENDRLFYSVLEDYVDITVKRERMKK
                     MKADPHYNALQVKYAYAVTCHKAQGGQWQNVFLDQGYMSDEYLTPDYFRWLYTAFTRAS
                     KTLYLVNYPEEQIE"
     CDS             complement(6046..7779)
                     /locus_tag="ctg488_10"
                     /transl_table=11
                     /translation="MKIKIYKSLAMCTLLLGLAACNDFEEMNTDPYAPVYDPEIIGATP
                     DGIDIDYELTPSALKSLQGTESAIGSVFANLTYEGLYNDYQVTTNLTHDIYAAYFANNV
                     SGFVTNSPTYGYNDGWSKRRWEHFYDNRTVEEYSQLIKTFWFCGKERYHNAFYMTRIYY
                     AFLISMQTDTYGAIPLEYYVKGAMPTDEKVKYMDQKDVYDVIFKMLDQAITALHNTPST
                     AQYSLGENDKCFGGDKDKWLRFANTLRLRLALRVSNVDPQLAKEQGEKAMADPAGLMQS
                     DDDNMKQTPKYSYITGGNENIYTLLYNWSANVVLSKEMERAYKEQSTILDPRCEILWWR
                     PTALEDLNQTEPKEDMTKDFNGCENGETSLGGSYTTTYSPSRVFIKQDQKKLDRKHWWC
                     YAREIVWLGYSESLFLRAEAALRGWAGAKGTAEDLYKEGIEASFNYYQIGADEEGQEKI
                     SKYMEGLKGLQAFKSGDREAQLEQIITQKWIAVYPNGNEGWAEFRRTDYPRYMKTPKGG
                     NNSGGEVANGKFIKRLRYPDSEVSNPNRPKDVDTQGTRLWWDVADTNDDGGNYVTPNNF
                     R"
     CDS             complement(7802..9679)
                     /locus_tag="ctg488_11"
                     /transl_table=11
                     /translation="MGIPNNIRLDDLKQYSTDGNAHVNWTGPTAGIRNPYYVLNQRHNS
                     DERWRAFGYYGMKINFTDWLHLSAKYAFDYYRTRIEETNAGDGINGESSIKDITDDEMN
                     REEQNFFESNAEIVLMGDKQLTDNFRLGFTVGGNFMYQNYESLNAGVRNMLDKGQWIFN
                     AANMLNTAGETGHERATNSVFGSLQLSWKEYLSLDLTARNDWSSTLPKKNNSFFYPSAN
                     LSFVVSDFVRSLDKTLPNWLTFAKVRLSAAQVGKDTDPYQLYNTYGFKFEKGELIPSKS
                     NVKMNDQLKPEISSSYEAGLDMKFLNNRLGFDFTYYYSRTKNQIMKVPAAAPWSGGKWV
                     NAGLITNKGFEMMIYSTPVQLKDFSFDLNVNLAKNVSNVEKLADGVDYIYFNGDSNFPI
                     NVGARPGHKLGEIYAKTLYKRDEQGNIIINKENGLPMTTTDADERLAKPIGNIQPNLLM
                     SVSPSFTYKGITLSAMFDMKFGGDIISISEMNATGSGMAKRTMNRGESDNFMMIFPGVY
                     EDGTPNTQKISASNYYGAQNAEDFIYDASFIKLKELAIGYTFPKSMLKKTPINSLNVSF
                     VARNLAYLLKHTPGTSPEGGYDTTMFSQAIDFMAVPYTRTFGFSVNLGF"
     CDS             10001..10702
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg488_12"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.7e-48, bitscore:
                     154.4, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LHRCSCNEHKEWLDSFLPYEQVEEEKVIRPELHPMGDTLSMGEVV
                     RAVSDATNHEAILVTDVGQNQMMSARYFKYSKDRSMITSGGLGTMGFGLPAAIGATFGR
                     PDRTVCVFMGDGGLQMNIQELGTIMEQKAPVKIIVLNNNFLGNVRQWQAMFFNRKYSFT
                     PMLNPDYIKIASAYDIPAKRVFTREELADAIDEMIATDGPFLLEACVIEEGNVLPMTPP
                     GGSVNQMLLEC"
     CDS             10716..11276
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg488_13"
                     /sec_met_domain="ALS_ss_C (E-value: 5.3e-19, bitscore:
                     58.4, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKTLYTLIVHSENFAGLLNQVTAVFTRRQINIESLNVSASSIKG
                     VHKYTITAWTDKDTIEKVVKQIEKKIDVLQAHYFTEDEIYFHEIALYKVSMPEFQSQPE
                     ASKVIRRYNARIVEVNPVFAIVEKNGISEEITSLYEELSALNCVLQFVRSGRVAITTSC
                     FERVNEFLADRETKYNLSKKEEK"
     CDS             11277..12020
                     /locus_tag="ctg488_14"
                     /transl_table=11
                     /translation="MSDNKKIGSYKFIAEPFHVDFNGRLTMGVLGNHLLNCAGFHASER
                     GFGIATLNEDNYTWVLSRLAIDLEEMPYQYEEFTVQTWVENVYRLFTDRNFAIIDKDGK
                     KIGYARSVWAMINLNTRKPADLLTLHGGSIVDYVCDEPCPIEKPSRIKVATDQPCAKLT
                     AKYSDIDINGHVNSIRYIEHILDLFPIDLYKSKRIQRFEMAYVAESYYGDELSFFEEEV
                     SENEYHVEIKKNGSEVVCRAKVKFV"
     CDS             12038..12622
                     /locus_tag="ctg488_15"
                     /transl_table=11
                     /translation="MKKIVFLLLLCVACCMNAQEFHLIPKVGLNLANTTGEVDSKVRPG
                     LNIGLGGDVMLTERFGIETGVYYSMQGSKYKGGGVSYTDKLDYINVPVYAKEFIYKGLY
                     VFGGPQFSFNVNSENKSSSDYGTTVIGMNVIRKFDCGVGLGAGYQFERGLLISLNYNIG
                     LINVNKSWASDSNPKANNSVVQLNVGWRFAL"
     CDS             12705..13748
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg488_16"
                     /sec_met_domain="IlvN (E-value: 1.3e-45, bitscore: 145.0,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 1.3e-40, bitscore: 129.1,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLNFGGVTENVVTREEFPLEKAREVLKNETIAVIGYGVQGPGQ
                     SLNLRDNGFNVIVGQRPGKTYEKAVADGWVPGETLFGIEEACEKGTIIMCLLSDAAVMS
                     VWPTIKPYLTAGKALYFSHGFAITWSDRTGVVPQKDIDVIMVAPKGSGTSLRTMFLEGR
                     GLNSSYAIYQDATGRAMERTIALGIGVGSGYLFETTFVREATSDLTGERGSLMGAIQGL
                     LLAQYEVLRENGHTPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMG
                     PFHDAIKPVVQKLYNSVKTGNEAQISIDSNSKPDYREKLEAELKALRESEMWQTAVTVR
                     KLRPENN"
ORIGIN
        1 atacaactcg acttgactca ggataaggaa ggagatgttt atgtatatgc aggaggagat
       61 aaaaactatc ctccgagtgc agttatgccg aacggttgtt tctttatcaa tgccatcgaa
      121 agacagcagc cgattgatga agataaactg gatcctatgg acaatctgga agagtttaac
      181 tccattaccg atgaagaatt ggatgcctac aagaaaaaan tgaatgaagc atctgccacc
      241 ggcagggcag tggtagccag tttcggtggc actgcattgg gagatgttgc ttttgtaccc
      301 ggtatggggc taaaagaacc gaagggtatc cgcagtgtgg tgcagccgaa cgcaataaac
      361 ttcgtccgga gaacaatcag gaaccttata catattctta tggagcaagt accaatatta
      421 cgatgccttg gaaaatgact ttggctacaa acatcgccaa tcaaagtcgt cgcggctatc
      481 gtgactcaag catgaaccgt gacgaactta tctggaatgc acaacttgcc cagtcattgc
      541 tgaaaggtgc tgctactgtt agttttgagg tttatgatat tttgagacaa cagagtaaca
      601 tcagccgttc attgtcagcc gatatgcgtt cggtatccga atataacggt attaatagtt
      661 actgtatggt acactttatc taccgtctga atatcttcgg cagtaaagct gctcgagaaa
      721 agatgatgaa tagtggtaga agaggttttg gtggacccgg tagaggtccc ggcggtggct
      781 ttggtggcgg acatccccgc ttttaataag atatcttgtt aacacaggca actttcctcc
      841 ggacagatgc aaaatctctt taattttgta tcggtccgga gggattatcg ttttgaatcg
      901 ggacagttgt tgttcgtatc cgatattttc catacatttg ttctttgtat aatccgcgga
      961 gggcgaatat gatagattgg aactacatag caagtgtaat agctaccgtt gcctttgata
     1021 ttatttattt cggggctatt atcggtacga ttgtcatcgt gattctcgac aatcgtaatc
     1081 cggtgaagac aatggcatgg attctgatcc tgatgtttct tccggttgta gggttggttt
     1141 tctatttctt ttttgggcgt agccaaaggc gtgagaagat tatcggtaag aaaagttatg
     1201 accgtttgct taaaaaaccg atggcagagt atttggcgca gaactgctgt gaaacgccga
     1261 aggaatatgc acggctgata cagctgttcc agaatacgaa ccaggctttt ccgtttgagg
     1321 gaaatcgggt cgatatttac actggcggat attctaaact acaagctctg ttgagagagc
     1381 tgcaaaaggc gaggcttcat attcatatgg aatattacat ctttgaggat gatcctgtgg
     1441 gacgattggt acgtgatgta ctgatcgaga aagcgcggga gggagtcgag gtgcgtgtga
     1501 tctatgacga tgtaggatgt tggcatgttc ctcatcgctt tttcgaagag atgagagatg
     1561 caggaattga ggtacgcggt tttttgaagg tccgttttcc cttgttcacg agtaaagtga
     1621 attatcgcaa tcaccggaag attgtggtga ttgacggacg tattggattt atcggtggaa
     1681 tgaatcttgc cgaacgttat atgcgtggct tttcgtgggg aatctggaga gatacgcata
     1741 tattgcttga aggaaaagcg gtacatggtc ttcagactgc ttttttgctc gattggtatt
     1801 tcgtggatcg cactctgatc actgcttcgc gctactttcc taagatagaa gcttatggca
     1861 attctttggt acagattgtg acaagtgaac cgatcggtcc ctggaaagag attatgcaag
     1921 ggttgacagt agccatatcc ggtgctaaga aatatttcta tatgcagacg ccttacttct
     1981 tacctaccga acaaattttg ggtgcaatgc agactgctgc attggcagga gtagatatcc
     2041 ggttaatgtt gcctgagcat gcggataatc gtgttacaca tttgggctcc tgttcttatc
     2101 tggcagatgt attgcgtgca ggagtcaagg tctattttta taaaaagggt ttcctgcatt
     2161 ctaaattaat ggtttcggat gatatgcttt cgacagtggg gtctaccaat ctcgatttcc
     2221 gtagttttga acataatttt gaagtaaatg cctttatgta tgatatggag acagcattgc
     2281 agatgcggga gattttcttg caggatcagc gggaaagtac tcagattttc ctgaagagct
     2341 gggaaaaacg ttcttcgcgt cagaaggcaa tggagtctgt agttcgatta ttggctccgt
     2401 tgctataagg aaaaccttct tcaatctatc tgaagaagga aaaattgaca ctcccgtata
     2461 cccttctttc tataaagtgg ggatgatctt caaagttatt ctttttgcca tgttccagaa
     2521 caaacaggcc atcctctttc agcaggttgt tcttgaaaat taaatccgga attgtttcca
     2581 actcttttag ttcataggga ggatcggcaa aaatgaaatc aaaccgttca tgactgccat
     2641 ttatgaattt aaatacatct ccacggatag gcaggcattt gtctgtttgc acctctttca
     2701 tgattttgct gatgaaagca tgatgggctc cgtctttctc cacactgatg acgcggtcac
     2761 acccacgtga aaccagctct atactgatac tgcctgtacc ggcaaacaga tcgagagcaa
     2821 caatgccctc ttcaaaatct atgtaattgg ataatacatt aaacagattc tctttggcaa
     2881 aatctgttgt cggacgtgcc ttgaaggttc tgggcacatc aaatcttctt cttttatata
     2941 ttccgctgat tactcgcatg ttaataaggc ttgcatgtca atattgcttg cagggttcat
     3001 tatgaatacc tgctgtatgt atttacgtaa ctcctgcatt agtttctctt tatcattaaa
     3061 tgcacctgtc aggtgaagtt cgtcccgttc ctgatcaaaa ttcaactgtt tccatagata
     3121 gagcagatag tagattcggt cacctgtttt gcgacattca aatgaattgg caagaagcag
     3181 atgcccacgc tcataacaga aaaagtcgat ggcatcacgg cgaatagaag catatatctt
     3241 tttactgttg cctaatctgc ttttcgccga aaaatattct gctaatggag ctgcttgtga
     3301 ataaaatctt gcttcgggat actgatcgga taagaattgg caagtacttt tatccatgcc
     3361 gaagatgact acggcattat tcttttttaa aatattatat tttaccgttt cattttcttt
     3421 gggagtgtgg ttatggtaga atatcatttc ggactgatca tcctcaaaca gttcaagggg
     3481 gattagggtg aaacgcttgt ctgccatcag aatgtttacc cgtttgtaag tatgattcag
     3541 aaagtccaat tcacggaaag cctgtttgag attggctgta agagataatg aagcctcgac
     3601 ctccttctca aagaaagaga gcgaactatc gtgaatcgga ttgtagatag aaaaagaaaa
     3661 tccatccgta ctaagacgga tggacaatgt atattgttcc gatttaccaa agtcaatcgt
     3721 ttctgcaatt gctctatcgg gcatattcgg attattccca gttacctgcg ccgttgttag
     3781 gagtatcgat agaacctacc atcaaaccgg catatttacc caatttaacc tgaaggtctt
     3841 tcaagtttgc aatttcttgc ttgtcaagtc cgttcaagta tacatcatat ggagtgttgg
     3901 cctggaacaa gaagatagga gctcctgatt tagttgtatc gtttttagtg tacatttcga
     3961 actgtgcacc attaccgaac ggaacatatc tcaaagagtc tgcattgaat gacttatcgt
     4021 agatcgtatc tgttacggca acccatattg tatcacgttt gaagcccatc aggccggcag
     4081 cttcaacttc tttccagttg ttagtctttt tagccttgtt gatcagagcc atggctttct
     4141 tttcagtcat accgtcttcc agctgcttgt cgctcaatac gccttcttta gatacgaaag
     4201 gaatcttttg tgtcttaacg aaatcgatca gtgtgtcaaa gcttgcagta tactgcttgt
     4261 aaatgttacg atattctgcc tgagctttac gaatatcaat caagcgggca acaactgctt
     4321 tgtctctgtg ctttttagct ttttcgaagt tgataggacc catgatacta gcatagcaaa
     4381 tgtaaaccaa agcaatggcg catacaccta gtacgatatt aaatactgtt ttcatgataa
     4441 atatgttttt tttagtttat attcgtagcg caaaaataaa ataaataaat ctaattaacg
     4501 atagttcttg taactttttt ctcgtacaaa aatgataaat aactatttag agcggcaaat
     4561 taaggaaaat ttttcttatc agccaacttt tgagcaagaa atagctgtaa aatctctttc
     4621 ggagtttcta ctttctacgg ctaatgatac ggtttttgtg cttcgtggat atgcgggaac
     4681 aggaaagact tctcttgtcg gggccttagt gaaagcgatg gataagttac aacagaaatc
     4741 ggttttactg gctcctacgg gaagagcggc taaagtattt tctgcttacg caggacaccc
     4801 ggcttttacc attcataaaa agatatacag gcagcagtct ttttcgaatg aagtaagtaa
     4861 tttttcaatt aatgataatc tgactactca tacattatat attgtagatg aggcttccat
     4921 gatttcgaat gaaggtttgt ccggttcgat gttcggtacc ggacgtctgt tggatgattt
     4981 ggtggagttt gtctattccg gtgcagggtg tcgtttattg ttgatgggag atacggctca
     5041 gttgcctccg gtaggagaag agcaaagtcc ggcacttgct accgaggcat tgaaaggata
     5101 tggactgaat gtcatagagg ttgatctcac acaggtggta cgtcaggttc agtcgtccgg
     5161 tattttatgg aatgccactc agattcggca gttgattgct gaagatgagt gtttttcgct
     5221 gcctaagata aaagtaagcg gatttccgga tatacaggtg gtacgtggcg acgagttgat
     5281 cgataccctg accggctgct acgaaaaaga cggaatggac gagacgattg tggtatgccg
     5341 ttccaataaa cgggctaata tatataataa aggtatacgt gctcagattc tttacaggga
     5401 agatgaactg aatacgggtg acttactcat ggtagcgaag aataattact tctggacaga
     5461 gaagtataaa gaaatagatt ttatagcgaa cggagagatt gctgtggttc gtcgggtgag
     5521 gcgtactcgt gaactgtatg gtttcaggtt tgctgaagta cttcttgcgt ttcccgatca
     5581 aaatgacttt gagttggaag ctaatttgtt gcttgatacg cttcattcgg atgcacctgc
     5641 tttacccaaa acagaaaacg accggctttt ttattctgta cttgaagact atgtggacat
     5701 caccgtcaag cgggagcgaa tgaaaaaaat gaaagctgac ccacactaca atgctctaca
     5761 ggtgaagtac gcttatgcgg tgacctgtca taaggcgcag ggcgggcaat ggcaaaatgt
     5821 ttttcttgac caggggtata tgtcggatga gtatctgaca cctgattatt tccgttggct
     5881 gtatacagct tttacgcgtg catcgaaaac tctctatctg gtgaattatc cggaagagca
     5941 aatagagtga ccggactata aataagacag ggaacccatc tcgggctccc tgtttctttt
     6001 gtgtaactta atttattgtc agtgcatgaa tatgaatctc gttgtttagc ggaagttgtt
     6061 tggggtaacg taattgcctc catcatcatt ggtgtcggct acgtcccacc ataaacgagt
     6121 tccctgtgta tctacatctt tcggacggtt cgggttagat acttcactgt ccgggtatct
     6181 caggcgtttg atgaacttcc cgtttgcaac ttcaccccct gagttgttgc ctcctttagg
     6241 tgttttcata tagcggggat agtctgtacg gcggaactct gcccatcctt cgttaccgtt
     6301 gggatatacg gcaatccatt tctgggtgat gatttgttcc aactgtgctt ctctgtcacc
     6361 actcttgaag gcttgtaagc ctttcaatcc ttccatgtat ttgctgatct tttcttgtcc
     6421 ttcctcgtca gcaccaatct gatagtagtt gaaggaagct tcaatgcctt ccttatagag
     6481 atcttcagcg gtacctttag caccggccca tcctcggaga gcggcttctg ctcggaggaa
     6541 caggctttcg gagtaaccca gccatactat ttcgcgtgca taacaccacc aatgtttgcg
     6601 gtcgagtttt ttctgatctt gcttgatgaa tacacggctt ggagaataag tcgttgtgta
     6661 gcttcctccc aatgaagtct caccgttttc gcaaccattg aagtcttttg tcatgtcttc
     6721 tttgggttcg gtttggttca ggtcctcaag agcggtcggt ctccaccaca atatttcgca
     6781 acgtgggtcg agaatggtcg attgttcttt ataagctcgt tccatttctt tggataacac
     6841 tacgttagca ctccagttgt acagaagtgt gtagatgttt tcgttaccac ccgtgatgta
     6901 cgagtatttg ggagtctgct tcatattatc atcatcgctt tgcatcaatc cggcagggtc
     6961 ggccatggct ttctcaccct gttctttagc aagttgggga tctacattcg atacacgtag
     7021 tgccaatcgt aaacgaaggg tattggcaaa acgaagccat ttgtctttgt cgcctccaaa
     7081 gcacttgtcg ttttcaccca ggctgtattg tgcagtagaa ggagtgttgt gcagtgcagt
     7141 gatggcctga tcgagcattt taaagataac gtcgtataca tctttctgat ccatgtattt
     7201 cactttctcg tctgtgggca ttgcaccttt tacgtagtat tccaatggaa tggctccata
     7261 agtgtctgtt tgcatagaga tcaggaatgc gtagtagata cgggtcatat agaacgcatt
     7321 gtgatagcgt tcttttccgc agaaccagaa tgttttgatc aactgactgt attcttctac
     7381 agtgcggtta tcgtagaagt gctcccagcg tcttttggac catccgtcgt tataaccgta
     7441 ggtaggcgag ttggtcacga atccgctaac gttgttggca aagtaagcag cgtagatgtc
     7501 atgagtcagg ttggtcgtaa cctgataatc attatacagt ccttcgtaag tcaggttggc
     7561 gaacaccgaa ccgatggcgc tttccgtgcc ttgaaggctt ttcagtgcac tgggtgtcag
     7621 ttcgtagtcg atatcgattc cgtcaggtgt ggcaccgatt atttccggat cgtataccgg
     7681 tgcgtaggga tcggtattca tttcttcgaa atcattacat gcagccagtc ctaacaggag
     7741 agtgcacatg gcaagcgatt tgtatatttt gattttcata ctgtatcttt aatttataaa
     7801 attagaaacc aaggttaact gagaatccga atgtacgggt ataaggtaca gccataaagt
     7861 cgatggcttg agagaacatg gttgtgtcgt aaccaccttc cggacttgtt cccggagtat
     7921 gtttcaacag ataagccagg ttacgtgcta cgaacgaaac attcagcgag ttgatcggcg
     7981 ttttcttcag catgcttttg gggaatgtat agccgatggc cagttccttc agcttgatga
     8041 aagaagcatc atagataaag tcttctgcgt tctgtgctcc gtaatagttg gatgctgaga
     8101 tcttctgagt attgggtgtt ccgtcttcgt atacacccgg gaagatcatc ataaagttat
     8161 cgctttctcc acgattcata gtacgtttag ccatacccga gcctgttgcg ttcatttcgg
     8221 agatagagat gatatcgcca ccgaatttca tatcgaacat ggccgacagt gtaatgcctt
     8281 tgtaggtgaa cgacggagat acagacatca gcaagttagg ctggatgttg ccgataggtt
     8341 tagccaggcg ttcgtcagca tctgtggtcg tcataggcaa gccgttctct ttatttataa
     8401 tgatgttgcc ctgttcgtca cgtttgtaga gagtcttggc atagatttca cccaatttgt
     8461 gacccgggcg tgcacctacg ttgatcggga agttagagtc gccattgaag tagatgtagt
     8521 ctacaccgtc agccagtttc tctacgttcg atacgttctt ggccagattg acattcagat
     8581 cgaaagagaa gtctttcaat tgtaccggtg tagagtagat catcatttcg aaacctttgt
     8641 tggtgatcag accggcattg acccatttac ctccactcca gggagcagcg gcgggcactt
     8701 tcatgatctg gttcttcgtg cggctataat aataggtaaa gtcaaatccc aaacggttgt
     8761 tgaggaactt catatccaaa cctgcttcgt aagaagaaga gatttccggt ttcagctggt
     8821 cgttcatttt cacgttcgat ttgcttggaa tcagctcacc tttttcaaat ttaaatccgt
     8881 acgtattgta taactgatac gggtccgtat ctttacctac ttgtgcggca gacaaacgta
     8941 ccttggcgaa agtcagccag ttgggcagtg ttttgtccag tgaacggaca aaatcagaaa
     9001 cgacaaaact taagttggca gacgggtaga agaaagagtt gttcttcttc ggcagtgtag
     9061 acgaccagtc gttacgggca gtcaagtcca gtgacagata ttctttccaa gagagttgca
     9121 aagatccgaa tactgaattt gttgcgcgtt catgtccggt ttctccggca gtgttcagca
     9181 tattggctgc attgaaaatc cattgtccct tatccagcat attgcgtacg ccggcattca
     9241 gtgattcata attctggtac atgaagttac cacctaccgt gaatcccaaa cggaaattgt
     9301 cagtcagctg tttgtcaccc atcaatacga tttctgcgtt cgattcgaag aagttctgtt
     9361 cctcgcggtt catttcgtca tcggtgatat ctttgatact gctctcaccg ttgataccgt
     9421 cacctgcgtt cgtttcttcg attcgggtac gataataatc gaatgcatat ttggcagaca
     9481 agtgcaacca gtcagtaaag ttgattttca ttccataata tccgaatgct ctccaacgtt
     9541 cgtcagagtt gtggcgctgg ttcaggacgt aataagggtt acggataccg gcagtaggac
     9601 ctgtccagtt tacgtgtgca ttgccatctg tcgaatattg tttcaggtcg tccaggcgaa
     9661 tattgttagg aatacccatc aattgagcga ttgctccgat aaagcgatag acaaggctaa
     9721 gcgtaatatc agtgctttgc tggatgttcg acctgaaaag gctgcggttg tgagaagtaa
     9781 tgagattgtt acggtggatc cgagatcggt tcttataaat gaaattattg agataaaagt
     9841 cggtgagcgt gtaccgttgg atggagtaat gttggatgaa gtgtgcatgg tatgcaccgg
     9901 gtgcagcagg agcttatgta gtagaatcta tcatccacaa ccagaaaaag atggttcctt
     9961 gctcagtaat gcttgaaggc gaatatggcg aatctgatct ttgcatcggt gttcctgcaa
    10021 cgagcataaa gaatggctgg atagtttcct gccttatgaa caggtggaag aagaaaaggt
    10081 aatccgtccg gaattgcatc cgatgggaga tacgctttcg atgggggaag tggtgcgtgc
    10141 ggtaagcgat gcgaccaatc atgaagcgat attggtgacc gatgtcggtc aaaaccagat
    10201 gatgtctgcc cggtacttta aatattcaaa agaccggagt atgattactt ccggaggact
    10261 tggtaccatg ggattcgggt tgccggctgc tatcggtgca acctttggcc gaccggaccg
    10321 tacggtttgt gtatttatgg gtgacggtgg tctgcaaatg aacattcagg agttgggaac
    10381 cattatggaa cagaaggcac cggttaaaat tatcgtatta aacaataatt tcctgggcaa
    10441 tgtacgccaa tggcaggcaa tgttcttcaa ccgtaaatac tcgttcacac ccatgctgaa
    10501 tcccgattat attaagattg cttctgctta tgatataccg gccaaaagag tctttacccg
    10561 tgaagaactg gctgatgcga ttgacgagat gattgcgaca gacggtccgt tcctgttgga
    10621 agcttgtgtg attgaagagg gaaatgtgtt gccgatgacc cctccgggag gttcagttaa
    10681 ccagatgttg ttggaatgct aataagttag gaattatgga taagacatta tatacattaa
    10741 ttgttcattc agagaacttt gccggattgt tgaatcaggt tacggcagta tttacccgtc
    10801 ggcagattaa tatagaaagc ctgaatgttt cggcttcatc tatcaagggg gtgcataaat
    10861 atactattac ggcttggacc gataaagata cgatagagaa ggttgtcaaa cagattgaga
    10921 agaagatcga tgtgcttcag gcacattatt tcactgaaga tgaaatctat tttcatgaaa
    10981 tagctcttta taaggtgtct atgcccgaat ttcagtcaca gccggaagct tcgaaggtga
    11041 ttcgtcgcta taatgcacgg attgtggaag tgaatccggt atttgccatc gtcgagaaaa
    11101 atggaatcag tgaagaaatt acttctctct acgaagagtt gagtgcattg aattgtgtgt
    11161 tgcaatttgt gcgttcggga cgtgtggcaa tcactaccag ttgctttgaa cgtgtgaacg
    11221 agtttctggc agatcgtgag accaaatata acttaagcaa gaaagaggaa aagtgaatga
    11281 gtgacaataa gaagataggg agttataagt ttattgcgga gccttttcat gtagacttca
    11341 acggacgttt gacaatgggg gtgcttggca accatctgtt gaactgtgcc ggctttcatg
    11401 ccagtgaacg cggctttgga atcgctacat tgaatgagga caattataca tgggtattgt
    11461 ctcgtctggc catcgatctg gaagagatgc cttatcaata tgaagagttt actgtacaga
    11521 catgggtgga gaatgtatat cgtcttttta ctgatcgtaa ttttgccatt atagacaagg
    11581 acggcaagaa gatcggatat gcccgttcgg tatgggccat gattaattta aatacccgca
    11641 agccagctga tttgctgacg ttgcatggcg gtagtattgt ggactatgta tgtgacgaac
    11701 cttgtccgat cgaaaagcct tcgcgtatca aagtggctac tgaccaacct tgtgctaagt
    11761 tgacagctaa atacagcgat atcgacatca atggtcatgt gaacagcatt cgttatatag
    11821 aacatatcct cgatttgttt ccgatcgatt tgtataaatc gaaacggatt cagcgatttg
    11881 aaatggccta tgtggcagaa agttattatg gcgacgagct ttcttttttt gaagaggaag
    11941 taagtgagaa tgaatatcac gtcgagatta agaaaaacgg cagtgaagtt gtatgccggg
    12001 caaaagtgaa gtttgtgtag tttaaaatgt gattaaaatg aagaagattg tttttctttt
    12061 gctgctctgt gttgcttgct gtatgaatgc acaggagttt catctgattc cgaaggtcgg
    12121 tttgaatctg gcaaatacta ccggggaggt ggattctaaa gtgcgtcccg gactcaatat
    12181 cggtctggga ggtgatgtca tgctgaccga acgctttgga atagaaacag gagtgtatta
    12241 ctccatgcag ggaagcaaat ataaaggggg cggagtctct tatacggata aactggatta
    12301 tatcaatgtt ccggtatatg cgaaagaatt tatatataag gggctgtatg tgtttggagg
    12361 gccgcagttc agtttcaatg tgaactcaga gaacaaatca tcctctgact atggtaccac
    12421 agtcataggc atgaatgtga ttcgcaagtt tgattgtgga gtggggcttg gagccggtta
    12481 tcagtttgaa cgtggtctgc tgatctctct aaactataac atcggactga ttaacgtaaa
    12541 caaatcttgg gcaagcgact ctaatcctaa agcaaacaat agtgtggtcc agctaaatgt
    12601 cggttggcgt tttgcactgt aagataaaga atataagttt aattattaat aatcggtttt
    12661 gttttcgtcc gaacggaaca agacttttaa aacaaaaaag aaaaatggca caattgaatt
    12721 ttggcggtgt tacggaaaat gtagtaaccc gtgaagaatt tcctttggaa aaagctcgtg
    12781 aggtattgaa gaatgaaaca atcgctgtta tcggttacgg tgtgcaggga ccgggtcaat
    12841 cactgaacct gcgcgataat ggcttcaatg taatcgttgg tcagcgtccg ggaaaaacat
    12901 atgaaaaagc agtggcagac ggctgggttc cgggtgaaac actgttcggc atcgaagagg
    12961 catgcgagaa aggtactatt attatgtgtc tgttgtcaga tgcagccgta atgtctgtat
    13021 ggcctactat caaaccttac ctgactgccg ggaaagcact ctatttctct cacggtttcg
    13081 caattacatg gagcgatcgc accggtgttg ttccacagaa agatattgat gtcattatgg
    13141 tcgctccgaa gggttcgggt acttcactcc gtacgatgtt ccttgaaggt cgcggactga
    13201 actcttcgta tgccatctat caggatgcta ccggcagagc tatggagaga accatcgcat
    13261 tgggtatcgg cgtaggttcc ggatatctgt ttgaaacgac ttttgtccgt gaagctactt
    13321 ccgacctgac aggtgaacgt ggttcgctga tgggagctat acaaggtttg ctgttggctc
    13381 agtatgaggt tttgcgtgag aacggtcata ctccatctga ggcatttaac gaaacggttg
    13441 aggagttaac tcagtcattg atgccgctgt ttgctaagaa tggtatggat tggatgtatg
    13501 ccaactgctc gactacggct cagcgtggtg ctcttgactg gatgggcccg ttccacgatg
    13561 ctattaaacc cgttgttcag aaattatata atagtgtaaa gaccggtaac gaggcacaga
    13621 tctctatcga ctctaattca aaaccggatt atcgcgagaa actggaggcc gaactgaagg
    13681 cattgcgtga aagcgaaatg tggcagacag ctgttactgt tcgtaaactt cgtccggaga
    13741 ataattgatc tgaatagatt atacaactta tgataaaagg aggaaactgc tgtttcctcc
    13801 ttttattttg cttgtaatta gtgttttgtg tctgagttgt tagaatggta tgttgtagaa
    13861 tatgaaaaat agatagattg tttggataga taaatcaagt ttaatatata tctttgtgcc
    13921 ctgatcaaac aacaaacaat attatatcat atgaaaaatc gtatttatac
//
