LOCUS       gnlProkkaIAKMFHHO_17   12139 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|IAKMFHHO_17.
ACCESSION   gnlProkkaIAKMFHHO_17
VERSION     gnlProkkaIAKMFHHO_17
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-30 20:19:45
            Original ID  :: gnl|Prokka|IAKMFHHO_17
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12139
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..1599
                     /gene_functions="transport (smcogs)
                     SMCOG1186:polysaccharide export protein (Score: 73.8;
                     E-value: 1.8e-22)"
                     /gene_kind="transport"
                     /locus_tag="ctg16_1"
                     /transl_table=11
                     /translation="MKEYRHHRCLRIIMKGNTQDDIRLQEGDVVIVPAYDVLVKISGKV
                     KRPMRFEMKKDENLATLIKYAGGFEADAYTRSLRVVRQNGEEYEVNTVKDMDYSIYTMR
                     NGDVVTAEAILNRFTNKLEIRGAVYRPGIYQLSGKLNTIRELVHEAQGLTGDAFLNRAV
                     LYRQREDLTSEVVQIDIKSIMNGTSPNLALMKNDILYIPSIHDLEDRGNVTVHGEVAHP
                     DSYPYADNMTLEDLIIQAGGLKEAASTVRIDVSRRIKNPRSTADNDTIGQMYTFSLKDG
                     FVIDGQPGFILEPYDQVYVRRSPGYQAQQNVVIDGEILFGGNYAMTNREERLSDLVNKA
                     GGPTSLAYLRGAKLTRVASAGEKKRMGDVIRLMSRQLGEAMIDSLGIGVEDTFTVGIDL
                     EKALTNPKGSADLVLREGDVVFIPKNTNTVTINGAVMVPNTVSYMKGKDVDYYLNQAGG
                     YSDNARKSKKFIVYMNGQVTKVKGSGKKQIEPGCEIIVPGKAKKKGNIANILGYATSFS
                     SLGMMIASIANLIKK"
     protocluster    1..12139
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[2825:7139]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2826..7139
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..12139
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12139
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             1614..2762
                     /locus_tag="ctg16_2"
                     /transl_table=11
                     /translation="MSEQRQDKNLLSEPHKTESDEIEIDLVDIFRKIIAIRKKLYKAVG
                     IGFIIGIIVAVSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVLFGKSLLASLRKELKNKEIEQDK"
     CDS             2826..3545
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 56.8; E-value:
                     3.3e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_3"
                     /sec_met_domain="NTP_transf_3 (E-value: 6.4e-17, bitscore:
                     52.2, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CGIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLITPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             3566..4867
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 209;
                     E-value: 1.4e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_4"
                     /sec_met_domain="CTP_transf_like (E-value: 2.1e-13,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 9e-122, bitscore:
                     395.5, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 1.1e-63, bitscore:
                     204.8, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKTILENERALEVRELCMPIKEILELIPGTK"
     CDS             4884..6008
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_5"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.2e-20, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1e-20, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             6018..7139
                     /NRPS_PKS="Domain: Aminotran_5 (30-335). E-value: 1.9e-33.
                     Score: 107.7. Matches aSDomain:
                     nrpspksdomains_ctg16_6_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 75.3; E-value:
                     7.2e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_6"
                     /sec_met_domain="Aminotran_5 (E-value: 6.3e-31, bitscore:
                     97.4, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVLVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        6108..7022
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg16_6_Aminotran_5.1"
                     /evalue="1.90E-33"
                     /label="ctg16_6_Aminotran_5.1"
                     /locus_tag="ctg16_6"
                     /protein_end="335"
                     /protein_start="30"
                     /score="107.7"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVLVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKIST"
     CDS             7136..7609
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1156:Chloramphenicol acetyltransferase (Score: 73.7;
                     E-value: 2.7e-22)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg16_7"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYSNIY
                     LGKNAEIRSGCYLIARDKIIIGENSTLAYGTTILTTADPNGPYNALAVLYPYKKAPVVI
                     GDNVWIGANVTILPGVTIGDYVVVAAGAVVTKDVPSGVLVAGVPAIVKKRFNK"
     CDS             7606..9051
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg16_8"
                     /sec_met_domain="Polysacc_synt (E-value: 9e-33, bitscore:
                     103.7, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEKTSLKNKAICGIFWSAVERFLSQGIQFVVTVIMARFLLPSDY
                     GMVGMLAIVLQLSQTLMDSGFTNALIRYKERTEIDYSTVFFFNILASLVIYFLIFFLAP
                     YISWFYKIGQLVEITRILSIVIVLNSFAIIPKTKLIIAVDFKTQSKVSFIAALVSGIIG
                     IWAAYLDFGVWALVGQTLVNGLLIVVLYAYFCRWKPLWIFSLKSFRLLFAFGSKLVLAN
                     ILNTLYKNLYAIVIGKKFSSVDLGFYTRAEQFAQFPSYNLSAIISRVTYPILSLVQNDN
                     DRLSALYRKYVRLSSAFIFPLMILLIVIAQPLVLLLLTEKWIGVVVLLQILCLDWMFDH
                     LSSINLNLLYVKGRSDLALRLEVIKKVLATGILLLSIPWGIVGMCWGRVMYSLIAVYLN
                     TYYTESLIKLSLIRQMRDILPSFFLALIMGGGTWYMILLLEGEIVQIVVGSVIALLLYG
                     TLLYCFSRSLFDEIWAVILKIKR"
     CDS             9051..9773
                     /locus_tag="ctg16_9"
                     /transl_table=11
                     /translation="MDKLSLIISKIRRNHWYRTYMRPIYLFVYGNRKLKNRNRIFLQYS
                     QELLTNFHQAMNEVGIPYWLEFGTLLGAVREHSFISHDFDLDVGLFKEDYSDIIREVLK
                     KYGFKRIRCITALDFIDAYEETYLYKGVTIDLFLFSREKNCDGVYCYDFVPVYSDIKRT
                     KKGDNAIRRIHFPRIDLIEYSFIGINTFVPENYEEHLCMHYGKDYMIPNPHWKDSDAQH
                     TDIFYGREIRIELFDKSK"
     CDS             9787..10800
                     /locus_tag="ctg16_10"
                     /transl_table=11
                     /translation="MFYLFFLLIVLFLLYIQSRKRQYSTVAGICVPIIIIFVVICRYRV
                     GYDYLTYYTLIENEEEAQILYLFSPLSIVWAEIALYFESPQMLFVLFGLPTFALLIFTL
                     KKYSKDYALSVTILICFFFFTSLSIIRQALALAICFYGYRFIVKRSLIKYILCILIAAL
                     FHPSAGVAIIIYWLPFLKFRLVVLLSIISIVAKPLFFYMLNILGVYTSYLDGKMDIEGG
                     KYTQLIYFLLFIICFVLGSKNIDKNKCNLFNVLLLSFVFVSFLGAHLGGRIAFYFNIYY
                     CLLIPKVVKGLDGQLREQVKLLSYFLCISYFLLYLFVPFIKGVPSYYIPYKFIFFK"
     CDS             10805..11764
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1123:polyprenol-monophosphomannose synthase ppm1
                     (Score: 57.2; E-value: 3.2e-17)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg16_11"
                     /sec_met_domain="Glycos_transf_2 (E-value: 1.1e-42,
                     bitscore: 135.7, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLISIIVPCYNSERYLSDCLLSILNQTYVNWEVICIDDGSQDNTL
                     SILNHYATLDERFKIISQSNAGVSVARNKALSQCQGEYICFVDSDDLIEPNFLITLLQL
                     ISHQADLAICGFTRSMVFCMDDAQGYIEMSGKRCIERIILDKSFNPQICCMLFRHNIIK
                     EKQLEFVIGCTRGEDREFILKYLVYSNKVCYTNNLLYHYRVNDQSAMAIFSIKSLTSIE
                     ASQRTVNYYKKVNYSVRGLEFEFSRTLWKFMILAILSGQNDLYQIIREKYDLKRQMEHL
                     YSHPGLSEKLTARLFVWNEALFKWVFSIIRYLYKKRWR"
ORIGIN
        1 cggaaagaat atcgccacca tcgatgttta cgaattatca tgaaaggcaa cacacaggat
       61 gacatccgcc ttcaggaagg tgacgtggtt atcgtccccg cgtacgatgt cttggtaaag
      121 atcagcggca aggtaaaacg tcctatgcgt ttcgaaatga agaaagacga gaaccttgcc
      181 actttaatca aatatgccgg cggctttgaa gctgacgcct acacccgttc attacgtgtt
      241 gtccgtcaga atggtgagga atatgaggtc aacacagtca aggatatgga ctacagcatc
      301 tacacaatgc gtaacggcga cgttgtaaca gccgaagcca tccttaaccg cttcacaaac
      361 aaactggaaa tccgtggcgc tgtctatcgt cccggcatct accagctcag cggtaaactg
      421 aatacgatcc gcgaacttgt ccatgaagcc cagggcctga ccggtgacgc tttcctgaat
      481 cgtgccgtcc tttatcgcca gcgtgaggat ttgaccagtg aagttgttca gatagatatc
      541 aagtctatca tgaacggtac ttccccgaac cttgccctga tgaagaatga cattctctac
      601 atcccgagca ttcacgatct ggaagatcgt ggcaatgtca cagttcacgg tgaagtcgcg
      661 caccccgatt cctatcccta tgctgataac atgacacttg aggatctgat catccaggcc
      721 ggtggcttga aagaagccgc ctctactgtc cgcattgatg tgtcgagacg aatcaagaat
      781 ccccgtagta ccgcggataa tgatactatc ggtcagatgt ataccttctc tttaaaggat
      841 ggttttgtca tcgacggtca gcccggtttt atccttgagc cttatgatca ggtttatgtc
      901 cgtcgcagtc cgggctatca ggcgcaacag aatgtagtca ttgatggtga aatattgttt
      961 ggaggaaatt atgccatgac caaccgtgag gaacgtcttt ccgatctggt gaataaagcg
     1021 ggtggtccta ccagtcttgc ctatctccgt ggtgcgaaat tgacccgtgt ggcaagtgcc
     1081 ggtgagaaga aacgtatggg tgatgtgatt cgcctgatga gcaggcaatt gggtgaagcc
     1141 atgattgact ctttgggtat tggtgttgag gataccttta cggtaggcat tgatctggag
     1201 aaggctttga ctaatcctaa gggtagtgcc gaccttgtct tacgtgaagg tgatgtggtc
     1261 tttataccta agaatactaa tactgtaact atcaatggtg ctgttatggt ccccaatacg
     1321 gtttcttata tgaagggaaa ggatgtggat tattacctga atcaggccgg tggctattct
     1381 gataatgcaa ggaagagtaa gaagttcatt gtttacatga atggtcaggt gacgaaggtt
     1441 aagggtagtg gtaagaaaca gattgagccg gggtgtgaga ttattgtgcc tggtaaggct
     1501 aagaagaaag ggaacatagc taatatttta ggttatgcta cttccttcag ttctttgggt
     1561 atgatgattg cttctattgc taatcttata aagaaataat agaatttact tttatgtcag
     1621 aacaacgaca ggataaaaac ttgctctctg aaccacacaa gacagaaagt gatgagatag
     1681 aaattgattt ggtcgatatc tttcgcaaga ttattgctat tcgtaaaaaa ttatacaaag
     1741 ccgttggaat tggttttatt attggaataa ttgtagcggt aagtatccct aaacagtata
     1801 cagtaaaggt taccctttct cctgaaatgg gtaatgcgaa ggggagtaat ggtttagccg
     1861 gacttgctgc ctcgttttta ggagatgggg ctctaatagg ggaaagcaca gatgccttga
     1921 acgcttctct ttcagcagat attgtttctt caactccttt tttattggaa cttttagaaa
     1981 tggaagtctc cgtttctaaa aaggatgata aaatgacttt ggggtcttat ctcgatgaag
     2041 agtcatctcc ttggtgggat tatcttatag gttttccggg catagtaata ggaggagtta
     2101 aatcattatt cggagaagat acggttcctg ccagtggagg gcggcaagga actatcgaat
     2161 tgacgaaaga agtaaatgag aagattaatt ttcttaaaaa gaagattagt gcatccattg
     2221 ataagaaaac cgccataacg agcattacgg tcaccttaca aaatccgcag atcactgcgg
     2281 ttatagcaga ttctgtcgtt cataaattac aggaatatat tattgggtat cgaacttcaa
     2341 aagtaaaaga agactgtgcg tatttggaac ggttgtttaa agaacgtcag caggaatatt
     2401 atgctgctca aagaaaatat gcggattatg tagacgccca tgataatgtg gttcttcaaa
     2461 gtgtacgtgc tgagcaggag cgtttacaga acgacatgag tttggcttat cagatatata
     2521 gtcaggttgc taatcagttg caggtatcca gagccaaagt acaggaggaa aagccagtct
     2581 ttgcagtagt tgagcctgcc gttgtacctt tgaaaccttc aggtatggga ctcaaaattt
     2641 atattttatt atttgtgttc ctgtccgtat ctggtactct cgtgtgggtg ctttttggca
     2701 aaagtctgct ggctagcttg agaaaagaac tgaaaaataa ggagatagaa caggataaat
     2761 gatgctaaaa cgtcgtttac aacattctta catcaattaa attcacttac tatattatta
     2821 aacgaatgat acgtacagct atgataatgg ctgcgggcat gggaacccgt tttggccaat
     2881 atacagaatt gatacctaaa gggttcgtca aagtgggagg tattccaatg atagttcgtt
     2941 ctattgatac tttgttatca tgtggcattg agcgaattgt aatcggtaca ggatataaac
     3001 aagaagttta tgaagaattg aagacagact atcctatgct tgaaacctgt tttagtcctc
     3061 gttatgctga aacaaatagt atgtatactt tatataatac gcgggagatt ctgggcaatg
     3121 atgatttttt attgttagag tcagatttga tttttgagaa acaagcaata atgagcttat
     3181 tggagtgtcc tgcggcagat gcaatgctaa taactccagt gacaaagttt caagatcagt
     3241 attatgtgga acatgatgat aattttcgcc tttcttcatg ttctgtcaat aagaataaac
     3301 taaacgctaa aggcgaattg gtcggcatcc ataaactatc cggttccttt tacaaaataa
     3361 tgtgtgctga ttatgcgagt attgttgatg aacaacccaa tttgggatat gagtatgaat
     3421 tactacgaat atcttgttct caatctcctg tttatgtgca taaagtagaa gggctgaaat
     3481 ggtatgaaat cgatgacata tcagatttgg aatatgcaga gaaatatatt gttccgtatt
     3541 gttaattaaa ataatatatc aaattatgag taagacagtt tatattggga tgactgcgga
     3601 tattatgcat ccaggactta tccgcattat taatgaggct actaaatacg gtgatgttat
     3661 aattggtctt cttacagata aagctattgc ggagcataaa cgccttcctt atctgaccta
     3721 tgaacaacga aaagaggtag ttcagaatat taaaggcgta tgtaaagttg ttcctcaaga
     3781 agaatggagc tatgttgaga atctcaaacg cattaaacct gactatataa ttcatggtga
     3841 cgactggaaa accgggcctt tacgtgaaga acgtgtgcgc gtatttgaag tgatgaatga
     3901 acagggagga aaggttatcg aaattccata tactttggga attaattcat cttctttgga
     3961 taaagatatt aaggctatag gtacaacccc tgatgtacgt ttaaaatcac ttcgtcgttt
     4021 gataaatgcc aaacccgtag ttcgtatttt ggaagctcat gatggactat gtggcttgat
     4081 aattgaaaat caggaaatat taaaagggga taagagggaa gtatttgacg gaatgtggtc
     4141 tagtagcctt acggattcaa ccagtaaagg taaacctgat attgaggcgg ttgatttaac
     4201 tacccgattg caagatttga ataatattct ggagtgtact actaaaccta ttatttttga
     4261 tggagataca ggtggtaaaa ttgaacattt cgtatttaca gtacgcactt tagaacgtca
     4321 tggaatctca gctataataa ttgaagataa agttggatta aaaaagaatt cattgtttgg
     4381 tacggatgtt attcaaactc aagatacaat cgaaggtttc tgtaataaga tcaaagcagg
     4441 aaaggcatct cagattactg atgattttat gattatcgct cgtattgaga gccttatagc
     4501 gggaaagccg gtaagtgatg ctttagagag agcttttgca tatgtccaag cgggagcgga
     4561 cggtattatg atacatagca aaaataagtc gggtgaagat ataaaagaat tttgtttggc
     4621 gtttcgaaaa cagtatgctc atgtacctat cgtggttgtg cctactacat atgatcatat
     4681 ttatgagtct gaattgtgtg attggggtgt gaatataatt atttatgcta atcatatgct
     4741 tcgtgccgct tatcctgcta tgatgaatgt cgcaaagaca atattagaga atgaacgtgc
     4801 tttagaggtg cgcgaactgt gtatgcccat aaaggaaata ttggaactga ttccgggtac
     4861 taaataaaaa gaggaatatc attatgttaa gcgtagaaaa agtttatgaa acgtttctga
     4921 gtcatgacgt tgattttttt acaggagttc cagactcatt actaaaaaat atttgtgcct
     4981 atatcacaga ccatacttca cgtgagaaac atatcatagc tgctaatgaa ggtgcggctg
     5041 taggaattgc ttcaggttat tatatggcat caggtaaggt tcctgtggtt tatatgcaaa
     5101 attccggctt gggtaatact gttaatcctc tgctgtctct tgcagatgaa caagtataca
     5161 gttttccaat gcttttgatg attggctggc gtggtgaacc gggaacaaaa gatgaacctc
     5221 agcataaaaa acagggtgag gtaactttag atttgttgaa agcaatgcgg attccttata
     5281 taattcttga ttcaaatgag aatgatgcat ttattcagct ccatgatatc atacaatcag
     5341 caaaaactaa gaatattcct catgcaataa ttattcggaa agatgttttt ggcaaatata
     5401 aacttcaaaa agagttcgga tgtaattatc ctttatctcg tgaggatgct ttgcaaatag
     5461 ttgtggatta tctgcctgaa aattcagtgg tcgtttctac tactggcaag ctttctcgtg
     5521 agttatttga atatcgagaa atgaaagagc aaggtcatga acatgatttt ctcacggtag
     5581 gctctatggg acatagttca tcaatctctt tgggtattgc tatagcaaag caagatagac
     5641 ctgtttattg cttggatggt gatggagcat ttattatgca tttaggggca attagtaaca
     5701 ttggcgattt atctcctaaa aactattatc atattttgtt taacaatggt gctcacgagt
     5761 ctgtaggagg acagcctact ttaggattta gtttagatat tccggctatt gtccggggga
     5821 gcggatataa gcatacttat actgtttgta caaaagttga aattgaagaa gcaatgaagc
     5881 agcttccaaa gttatgtggt cctgttttgt tggaaataaa ggttaaaata gattctcggg
     5941 agaatttggg acgtcccacg actactccta tagagaataa ggagcatttt atggattttt
     6001 taaaataaat atattcgatg aaaatagaaa gaaaaatatt attaaatcct gggcctgcca
     6061 ctactactga cagtgtaaaa atggcacaag ttgttccgga tatttgtcct cgcgagaaag
     6121 aattcgcagg tatgatgaaa caacttcggg acgatttggt cagagttgct catgggaatt
     6181 tggaaaaaca taccgctgta ttattttgtg gctcaggaac catcaatatt gatatatgtc
     6241 taaattctct tcttcctgaa gacaaaaggg tgcttatagt gaataatggg gcatatagta
     6301 cccgtgctgt agaagtgtgt caatattatg gtttgcctca tattaatttg gaattttccg
     6361 tttacgaacg tcctgattta tcggtggtgg aaaatgtgtt gcaagaaaat cctgatatag
     6421 ctatggttta tactactcat cacgagacgg gtacaggaat tctgaaccct attcgcgaga
     6481 tgggcgctat agctcataaa tatcaggcta aatttgtcgt cgatactact tcttctttgg
     6541 gcatgattcc ttttgatata gagaaagata atgtggattt ttgtatggca tctgctcaaa
     6601 aaggacttca agcgatgaca ggtctttctt ttattatagg caatgaggaa cagattaagt
     6661 tttcaaaaaa atatcccaag cgttcttact attgtaatct ttatttgcag tatgagaatt
     6721 ttgagagaac aggtgaaatg cattttactc caccggtaca aactatttac gccactcgtc
     6781 aggcattaaa tgaatatttt gaagtgggcg aagaagctaa gtttgcccgt cacaaaagag
     6841 tttttgaggc tattcattca ggtataaatg aaattggtct taaaagtgta ataaagcgtg
     6901 aatggcagtc aggactggtt gtcttagttc aatacccaga agatcccaac tgggattttg
     6961 agaaaataca tgattattgt tatgagcgtg gatttacgat ttatccaggt aagatatcaa
     7021 ctgaggatac ttttagaatc tgtgctttag gagagataga agtagatgat attgagaact
     7081 tctttaaagt actaaaagct gcattaaatc attataacgt cacattaccg atgtcatgat
     7141 tgcagaaata ttattgaaga ttcgtcattt ttatttttcc cttcgtggta tacacttcca
     7201 tccggaaagt gttatttctg gagtgcctat tcgtagcttt cgcttagtag gcaaatatag
     7261 caatatctac ttaggtaaaa atgctgaaat acgttcaggc tgttatctga ttgctcgtga
     7321 taaaatcatt attggagaaa actcaacact cgcctatgga acgactatat tgacaactgc
     7381 tgatcctaat ggaccgtata atgcattagc agttctttat ccttataaaa aggcaccggt
     7441 agttatagga gataatgttt ggattggggc taatgttacc atccttcctg gagtaactat
     7501 tggtgattac gttgtagtag cagctggagc tgttgtaaca aaagatgtac cttcaggagt
     7561 attggtagct ggtgtaccag ctattgtgaa aaaacgtttt aataaatgaa agaaaaaact
     7621 tctttaaaga acaaagccat atgtggaatc ttttggagtg cagttgaacg atttttatca
     7681 caggggatac agtttgtagt tacagtcatt atggcgcgtt ttctattgcc atctgattat
     7741 ggaatggtag gaatgttagc aatagttctt caattatctc aaacgttaat ggatagtggt
     7801 tttactaatg cccttattcg ttataaggaa cgtactgaaa ttgattattc aacagttttc
     7861 ttttttaata tattagcatc attagttatt tattttctaa ttttttttct agctccttat
     7921 atatcgtggt tttataaaat aggtcaatta gttgagatta ctagaatttt atctattgtt
     7981 attgttttaa attcctttgc gattattcct aaaactaaat taataatagc tgtagatttt
     8041 aaaactcaat caaaagtctc atttattgca gctttggttt caggtattat tggcatttgg
     8101 gctgcatatt tagattttgg agtttgggct ttagttggac aaactttagt aaacggattg
     8161 ttgattgtag ttttgtatgc atatttttgt agatggaaac cattgtggat attttcattg
     8221 aaatcgtttc gtttattatt tgcttttggg tcaaaattag tattagctaa tattcttaat
     8281 actttatata aaaatctgta tgctatagtt ataggaaaga agttttcgtc ggttgattta
     8341 ggattttata ctcgtgcgga acaatttgct cagtttcctt catataattt gagtgcaata
     8401 atttctagag tgacataccc catattgagc cttgtgcaaa atgataatga tagattatct
     8461 gctttatata ggaaatatgt ccgtttatct tctgctttta tctttccatt gatgattttg
     8521 ttaattgtca tagctcagcc actggtatta ttgcttttga cagaaaaatg gataggagta
     8581 gttgtattgc ttcaaatatt gtgtttagat tggatgtttg atcatttgag tagtataaat
     8641 ttgaatttac tatatgtaaa gggacgttca gacttggctt tacgtttaga agttataaaa
     8701 aaagtgttag cgacggggat ccttcttcta tctattcctt gggggattgt aggtatgtgt
     8761 tgggggcgtg ttatgtattc attgattgct gtgtatttga atacttatta tacagaatca
     8821 ttgattaaat taagtcttat tagacagatg agagatatac taccaagctt ttttttagca
     8881 ttaataatgg gaggaggtac ttggtatatg attttattgt tagagggtga aattgttcaa
     8941 attgtagtag gaagtgttat tgctttattg ctatatggaa cgttgttgta ttgcttttct
     9001 cgatccttgt ttgatgaaat atgggcggtt atattaaaaa taaaaaggta atggataaac
     9061 tgagtttgat tattagtaaa atacgacgga atcattggta tagaacctat atgcgtccta
     9121 tatatttatt tgtttatggc aatagaaaat tgaagaatag aaatagaata tttttgcagt
     9181 attcacaaga gctgctaact aactttcatc aagcaatgaa tgaagtggga attccttatt
     9241 ggttagaatt tggaactctt ttaggtgctg ttagagaaca cagttttata agtcatgatt
     9301 ttgatcttga tgtgggcctt tttaaggaag attattcaga tataataaga gaggtcttaa
     9361 aaaaatatgg tttcaaaaga ataaggtgta taaccgccct tgattttatt gatgcttatg
     9421 aggaaactta tctttataaa ggtgtgacaa ttgatctttt ccttttttca agagagaaaa
     9481 attgtgatgg ggtctattgt tatgattttg ttccagtata ttcagatata aagagaacta
     9541 aaaaaggtga taatgcaatc cggagaattc attttcctag aattgatttg attgaatatt
     9601 catttattgg aattaatact tttgttcctg aaaattatga ggaacatctt tgtatgcatt
     9661 atggtaaaga ctatatgatt ccaaatcctc attggaaaga ttcagatgcg caacatactg
     9721 atatctttta tggtagagag attagaattg aattgtttga taaaagtaaa taatagtaga
     9781 taatacatgt tctatctatt ttttttacta attgtgctat ttttgttata tatacaaagt
     9841 aggaaaagac aatattctac tgtagcggga atttgtgttc ctattattat aatttttgtt
     9901 gtaatttgtc gttatagagt ggggtatgac tatttaacgt attatacatt aattgaaaat
     9961 gaagaagagg cacagatttt atacttattt tctcctttaa gcattgtttg ggcagagatt
    10021 gctttatatt ttgaatctcc acagatgtta tttgttcttt ttgggcttcc aacatttgct
    10081 cttctaatat ttactttaaa aaaatattca aaagattatg cgttatcagt aactatttta
    10141 atttgtttct tcttttttac atcactcagt attattcgac aagctttggc tttggctatt
    10201 tgtttttatg gttatcgttt tatagtaaaa cgttcactaa ttaaatatat attatgtata
    10261 ttgattgcag ctttattcca tccttctgca ggagtagcga ttattatata ttggttgcca
    10321 tttctaaagt ttagattagt tgtattatta tctataatat caatagtagc caaaccttta
    10381 tttttttata tgctaaatat attaggggtg tatacctctt atcttgatgg caagatggat
    10441 attgaaggtg ggaaatatac tcaattaata tactttttgt tgtttattat ttgttttgtt
    10501 ttgggaagta aaaacataga taaaaacaag tgtaatttat ttaatgtttt attgttaagt
    10561 tttgttttcg tatctttttt aggagctcat ttaggcggga gaatagcgtt ttattttaat
    10621 atatattatt gtttgttgat tcctaaagtg gttaaaggat tggatgggca actaagagag
    10681 caagtgaagc ttctttctta ttttctatgt atttcttatt tcttattgta cctattcgtt
    10741 ccattcataa aaggtgtacc ctcatattat atcccatata agtttatatt tttcaaatag
    10801 taaaatgttg atatctataa ttgtcccttg ttataattct gaaagatatt tgtctgattg
    10861 tttattgtct atattgaatc aaacctatgt taattgggag gtgatttgta tagatgatgg
    10921 aagtcaagat aatacattat ctattttaaa tcattacgct acattggatg agcgttttaa
    10981 aattatttct cagtctaatg caggagtgtc tgtcgcaaga aataaggctc tatcccagtg
    11041 tcaaggagag tatatttgct ttgttgatag tgatgacctg atagaaccta attttttgat
    11101 aacactttta cagcttataa gtcatcaggc tgatttggca atctgtggtt ttactcgttc
    11161 tatggttttc tgtatggatg atgctcaagg atatatagaa atgagtggta aacgttgtat
    11221 agaaagaatt attctagata aaagtttcaa tcctcagatt tgttgtatgt tatttcgaca
    11281 taatattata aaagagaaac aattagaatt tgtgataggg tgtactcgtg gtgaagatcg
    11341 tgaatttata ttgaaatatt tagtttattc taataaggtt tgttatacaa acaatcttct
    11401 ttatcactat cgtgtaaatg atcagtcagc catggcaatc ttttctatta aaagtttgac
    11461 aagtatagaa gcttcacaac gcacggtcaa ctactataaa aaagtgaatt attctgttag
    11521 agggcttgaa tttgaatttt cacgtacatt gtggaaattc atgattttag ctattttgtc
    11581 tgggcaaaat gatttatatc aaatcattcg agaaaagtat gatctaaaaa gacaaatgga
    11641 acatctttat tctcatccag gactatccga aaaacttaca gcgagattgt ttgtttggaa
    11701 tgaggcactt tttaaatggg tattttctat tattagatat ctatataaaa aaagatggag
    11761 atgaataaac gaaatagatt atctgaacaa gaaataaaaa aagtagaact tgacgcttta
    11821 ttgtatattc ggaaaatttg tcagcaatat catcttcgct attatttagc ttggggtact
    11881 ttgttgggag ccgttaggca taaaggattt attccttggg atgatgatat tgatataatg
    11941 atgccacgtt cagattatga gcgattattg gagttagttc cttccttgag acatagttat
    12001 tataaaatct taagtaatcc aaagaatgag gattattatt atactcatgc aaaaatgata
    12061 gatactcgta ctttgtgtgt ggaaaatgat ttgcaaacta ttcaaaatat ggggatttgg
    12121 gttgatattt tccccttag
//
