LOCUS       gnlProkkaGPLDCMJG_69   11395 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GPLDCMJG_69.
ACCESSION   gnlProkkaGPLDCMJG_69
VERSION     gnlProkkaGPLDCMJG_69
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-30 20:12:33
            Original ID  :: gnl|Prokka|GPLDCMJG_69
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 6349
            Orig. end    :: 17744
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11395
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[5000:10059]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..10059
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..11395
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..11395
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             complement(688..1695)
                     /locus_tag="ctg53_9"
                     /transl_table=11
                     /translation="MRQIVTCTGHGGTGSSFITDFFKEFENVKSTGDFEFTLSYDVDGI
                     YDLYHNISHYSGFHIAESFDRFDKLCSDIRKSYKNTLGCDIYPLLKDYISAITEVDWNG
                     FWPEHVRREPYIKKILLYYLPNIIQRNLNKIVKFNGDYEYVDRTIRQSMRLSVDSSLFL
                     QETRKLYNKIFDIVDDSNECTHLVLDRLVPPTNIEDYMIFIDNLKVVVVDRDPRDLYLL
                     NKKYWHEGWIPEDVDKFIKLYRFHRLRDKERDLIEDHSSILRVKFEDGIFDYDNTSAQL
                     CDFVGVNRGRHTKKMQFFNPDISRKNVQLWKYEKCYFADVLKIEKELTEFLYIV"
     CDS             complement(1680..2603)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg53_10"
                     /sec_met_domain="Glycos_transf_2 (E-value: 3.9e-25,
                     bitscore: 79.0, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDTFSLFLITRNRPHLLKLALNSVLNQTISNFPIIVSDNSTNNET
                     KEMVESLYLNQSNIIYRKREREYGLIEHWNKVLSEVRSEYFMIFHDDDVMHPDMIRTML
                     NIIKKDHSLAFIATNARIIKKGRICYSKYKGKEKIMRLKEARELFQMYAVGNWIPPFPS
                     YIYSKSIADNMRFAEDKGGKYCDVAFLLDAFDLGNLAIITKPYMDYYYHDGQVSQFNDY
                     FQRIKLINYVRQKMRISPHDRPLVNFKLMNLYCWINNLVRNSDDLVSKKRFINCLKIFL
                     KHRKYMYVFKLLGCIILREKMKCGKL"
     CDS             complement(2607..3020)
                     /locus_tag="ctg53_11"
                     /transl_table=11
                     /translation="MSSINIESKIKIISRRKISDNRGWFLKIIDGKENSLPNYTGEIYI
                     VSAISGESRGGHYHNRAIEWFTLVEGNAVLKLEDIRTNEKKEIYLNDQEPVTVFVPPHI
                     AHEFINIDSVPFIVIAYTDQLYKPEDTIQYILK"
     CDS             complement(3013..3891)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score: 60.1;
                     E-value: 3.9e-18)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg53_12"
                     /transl_table=11
                     /translation="MLSNSIGTVLKKVGYFIQVIGKSSPVAFAPDVFIRKNLLEDAVYI
                     TELLDSDVIIYAAGAGVQAAVPIAANTMYTMNLLVPIKLCLLLNEHNYLGTFVSFGTYM
                     EIGCNDEMYKSFNEDELLHSCLPVTNDYVLSKRLFTHYIHNANFVFRKYHFVLPNLFSR
                     DEVGTRLLPYVVNYLRERKKCNKVEQPRFSSGSQIRQYVFIEEVIEAIFKCIEGEVVSG
                     IYNIGGGQTATIREFIEELFNAFCVDVDEHMFGKELRRDNDILSLSLNDAKLYKAIHYS
                     PIIKITDIYHE"
     CDS             complement(3921..4997)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     137.4; E-value: 1.1e-41)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg53_13"
                     /sec_met_domain="RmlD_sub_bind (E-value: 7.4e-11, bitscore:
                     31.9, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 9.9e-16,
                     bitscore: 47.9, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVDVFNNFYRGKRVLVTGHTGFKGSWLSIWLYELGAEVVGVSLD
                     PITERDNYVLSGIGQKIKADIRADICDGESMKGIFQEYQPEIVFHLAAQPLVRLSYNIP
                     VETYETNVMGTIHILEAIRVTNSVKVGVMITTDKCYENKEQIWGYRENEPMGGYDPYSS
                     SKGAAEIAIASWRRSFFHPKQYKKHGKSIASVRAGNVIGGGDWALDRIIPDCIKALEAG
                     RTVDIRSPKAIRPWQHVLEPLSGYMLLAQKMWDEPTQYCEGWNFGPRAESISTVWDVAS
                     RVVESFGCGELRDLSDPNALHEADLLMLDISKVKFQLGWEPRMNIDQTVRLTVDWYRRY
                     QKEEMYKVCVEQIEKYIR"
     CDS             complement(5001..5780)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 151.1; E-value:
                     6.3e-46)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg53_14"
                     /sec_met_domain="NTP_transf_3 (E-value: 1.7e-11, bitscore:
                     35.0, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKAVILAGGFGSRLSEATNLIPKPMVEIGGKPILWHIMKIYSYYG
                     INEFIICCGYKQYVIKEYFANYFRHNCDMTVDLSNNSTTILDNHSENWKVTMIDTGVNT
                     MTGGRVKRIQKYVGNECFLLTYGDGVADLDISDTIKVHKESKAILSLTAYKPHGKFGLL
                     DISSETNMVKSFLEKPDGDGNWINAGFFVCEPKVFDYIPANDDSIVFEKQPLESIARDG
                     KMYAYKHCGFWKPMDMLRDNIELNEMWNNGKAPWKVW"
     CDS             complement(5777..6895)
                     /NRPS_PKS="Domain: Aminotran_5 (30-299). E-value: 6.2e-34.
                     Score: 109.3. Matches aSDomain:
                     nrpspksdomains_ctg53_15_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 80.5; E-value:
                     2e-24)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg53_15"
                     /sec_met_domain="Aminotran_5 (E-value: 1.5e-31, bitscore:
                     99.9, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIERKILLNPGPATTTDTVKLAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGDLSKHTAVLFCGSGTINIDICLNSLLPADKKVLVVNNGAYSTRAVEVCEYY
                     GLPHIDLKFSVYELPDLSVIEKTLSDNPDIALVYTTHHETGTGILNPIREIGKIAHSHG
                     AVFVVDTTSSLGMIPFDIGKDNVDFCMASAQKGLQAMTGLSFIIGDESLIRASRDYPKR
                     SYYCNLYLQYDYFEKTGEMHFTPPVQTVYAARQALDEYFAVGEEAKFARHKRVFEAIHK
                     GLQELGLQYAIKREWQSGLVVSVLYPDDPLWDFDKVHDYCYERGFTIYPGKISTTNTFR
                     LCALGEIDVEDIERFFEVMREAFSLIKNITNL"
     aSDomain        complement(5999..6805)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg53_15_Aminotran_5.1"
                     /evalue="6.20E-34"
                     /label="ctg53_15_Aminotran_5.1"
                     /locus_tag="ctg53_15"
                     /protein_end="299"
                     /protein_start="30"
                     /score="109.3"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGDLSKHTAVLFCGSGTINIDICL
                     NSLLPADKKVLVVNNGAYSTRAVEVCEYYGLPHIDLKFSVYELPDLSVIEKTLSDNPDI
                     ALVYTTHHETGTGILNPIREIGKIAHSHGAVFVVDTTSSLGMIPFDIGKDNVDFCMASA
                     QKGLQAMTGLSFIIGDESLIRASRDYPKRSYYCNLYLQYDYFEKTGEMHFTPPVQTVYA
                     ARQALDEYFAVGEEAKFARHKRVFEAIHKGLQELGLQYAIKREWQSG"
     CDS             complement(6892..8028)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 71.8;
                     E-value: 7.9e-22)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg53_16"
                     /sec_met_domain="TPP_enzyme_N (E-value: 2.9e-22, bitscore:
                     69.4, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 7.6e-21, bitscore:
                     64.8, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVSVEKIYDTFLHHGVDFFTGVPDSLLKNICAYITDHAPRGKHII
                     AANEGSAVGIACGYYMASGNVPLVYMQNSGLGNTVNPLLSLADEKVYSLPLLLLVGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMKIPFIILDTDEDEALAQIHDAVVSAKSRSIPHAIV
                     IRKDTFGKYKLRQEALNDYPLSREEALMQVVDHLGDNDIVVSTTGKLSRELFEYRESKG
                     QGHARDFLTVGSMGHSSSIALGVALEKPDRRVYCLDGDGAFIMHMGAVSNIGDLSPKNY
                     RHVLFNNGAHESVGGQPTLGFRLDIASIAKGCGYAHVLTASDKEGLSCALEKLSGLSGP
                     VLLEIKVRIDSRDDLGRPTTTPVENKEHFMAFLKDTHS"
     CDS             complement(8040..9422)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 213.9;
                     E-value: 4.7e-65)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg53_17"
                     /sec_met_domain="CTP_transf_like (E-value: 2.7e-12,
                     bitscore: 37.4, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 2.1e-122, bitscore:
                     398.0, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 1e-64, bitscore:
                     208.6, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSMMKPTFRMPRSTSSAIVKNKSFPYMNKKIYVGMTADIMHPGL
                     IHIIHEATKYGDVIVGLLTDKAIAEHKRLPYLTYDQRKEVVENIKGVFEVVPQEDWSYV
                     PNLEKLKPDYIIHGDDWKTGPLREVREQVFEVMNAQGGKVIEIPYTRGINSSSLDKDIK
                     AIGTTPDVRLKSLRRLIQAKPVVRILEAHDGLCGLIIENLEVQKGDKREVFDGMWSSSL
                     TDSTSKGKPDIEAVDLTTRLQDLNNILECTTKPIIFDGDTGGKIEHFVFTVRTLERHGI
                     SAVIIEDKVGLKKNSLFGTDAIQTQDSIEGFCDKIRAGKNAQVTGDFMIIARIESLIAG
                     KPMSDALERAYAYVQAGADGIMIHSKDKSGEDIREFCRTFRKEYAHVPIVVVPTTYDHV
                     HESELHEWGANVVIYANHLLRAAYPAMMNVARTILENERAEEVRPLCMPIKEILELIPG
                     TK"
     CDS             complement(9361..10059)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg53_18"
                     /sec_met_domain="NTP_transf_3 (E-value: 2.2e-14, bitscore:
                     44.4, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAGLGTRFGHYTELVPKGFVEVGGKPMIIRSIETLLSCGIERII
                     LGTGYKKEAYEALQADFPQIETCFSPRYADTNSMYTLYNTRDVIGDDSFLLLESDLVFE
                     RKAILSLLDDEFPDVMLVSSLTKFQDQYYVEYDRNHILTSCSVDKNALEAKGELVGIHK
                     LSNTFYRRMCADYATILESQPKLGYEYELLRMSRSVSPVRVLRVEGLKWYEIDDEADLS
                     YAEEHIIRYC"
     CDS             complement(10073..11356)
                     /locus_tag="ctg53_19"
                     /transl_table=11
                     /translation="MIRSFLSRSPLYVLALYASVLIFLVYTCAYAYRKPFTAAIYEGEI
                     LWGFDVKILYVLSEIIGYALSKFIGVRILPSMKAGHRIYYIIGLLTFSEVALLGFALLP
                     VPLKVCSIFLSGLPLGMIWGVIFSYIEGRRISEILNVGLSVALIVSSGLVKTLGQFVMD
                     NLHVSEYWMPFTTGLLVYPVMLLCSWLLNQIPAPNEQDIIQRTKRAPMDGKDRRKFLRQ
                     FFWGICMLVVFYGALTVFRELRDSFAADIWKELHIEGAMIFTQTEVPIAVFVLVLMFLI
                     VFVRNNRLALNIIYCIAVTGGSLMVFSTLLYVYGFLSPIWWMILSGLGLYMGYIPFTYL
                     IERLIASLRVVSTAVFIIYLADSFGYLGTTGVFMVKNFVSADISWTVMLMRTALFSGFV
                     SVLSIFAIYCYFKQQLNSLILIPSEIHD"
ORIGIN
        1 taaaaaggga aagcttcaca taaataggca tcagcaatct tctcggtcca atatcctttt
       61 tctcgacagt tctcgaaagc caacacatac ttatattttg aatagatatc atatttatct
      121 ataacaaaat caaagccttc accataaata tccaaaagat ctggtattat tgattttaat
      181 ttcaatataa aatccaatcg ctgacgatgt cctcgagtca atgttttatt tgaagtaatc
      241 accgcaactt tattcttttt atcacaagtt actctttgtt gtaaagtatc ataatctaag
      301 aaattatctt tatcccaagc ttttaaatca aaatcaaatt tagagcctac catccacggc
      361 aataatggaa atgaagaaat ggtatttcct ttataacgag aaaaatttct aaatgaaaca
      421 atattaccaa attgattaat atatttagag ctatataact taacagaagc cggctcacaa
      481 atacataaaa aagtattttc ttttccacat ttaacaggaa tatcccctaa aatagaatca
      541 atgacaaata aacaatcaca gtcttcacta cccgagttta agataaactc acaattcccc
      601 catttaggaa tttgcttggg aaaatgtttt attaaagggt gggtagtagc actatatact
      661 gcaactttcc aaatctgttc cataactcta aactatatat aaaaattccg ttaactcttt
      721 ttctatcttc agaacatctg caaaataaca tttctcatat ttccataatt gaacattttt
      781 tctcgaaata tccggattaa aaaactgcat tttctttgta tgccttcctc tatttactcc
      841 tacaaaatca cataattggg cacttgtatt atcataatca aaaataccat cctcaaattt
      901 cactcttaaa atagacgaat gatcttctat taagtctctt tctttatctc ttaaacgatg
      961 gaaacgatat agcttaataa atttatcaac atcttctgga atccatcctt catgccaata
     1021 tttcttattc aataggtata aatctctggg gtctctatcc acaaccacaa ccttcaaatt
     1081 atcaatgaat atcatgtaat cttctatatt tgtaggaggt accagtctgt ctaataccag
     1141 atgtgtacat tcattagaat catcaacaat atcaaaaatt ttattatata actttcttgt
     1201 ttcctgtaaa aacaacgatg aatcaacaga aagtctcata gactgcctaa ttgttctatc
     1261 aacatattca taatcaccat taaattttac aattttattt agatttctct gtattatgtt
     1321 aggaagataa tacaaaagaa ttttttttat atatggttca cgccttacat gctcaggcca
     1381 aaatccattc cagtcaacct ctgtaattgc agagatataa tcttttaaca aaggatatat
     1441 atcacatccc aatgtatttt tatacgattt acgaatatca ctacacaatt tatcaaaacg
     1501 atcaaaagat tcagctatat ggaaaccgct ataatgactt atattatgat ataaatcata
     1561 aataccatca acgtcataac tcaatgtaaa ctcaaaatct cctgttgatt ttacattttc
     1621 aaattcttta aaaaaatctg taataaagga agagcctgtt cctccatgtc ctgtacaagt
     1681 tacaatttgc cgcatttcat tttttctcta agaataatac accctaacaa tttgaaaaca
     1741 tacatatact ttctatgttt aagaaagatt ttaagacaat tgatgaatct ctttttcgaa
     1801 actaaatcat cggaatttct aaccaaatta ttaatccaac aataaagatt cattaattta
     1861 aaattaacta aaggacgatc gtgaggagat attctcatct tttgacgtac ataatttatc
     1921 aattttattc tttgaaaata atcgttaaat tggcttactt gcccatcatg ataataataa
     1981 tccatatatg gttttgtaat aatagctaaa ttccccagat caaaagcatc taaaagaaaa
     2041 gcaacatcac aatattttcc acctttatct tctgcaaatc tcatattatc agcaatagat
     2101 tttgaatata tgtaagacgg aaagggagga atccaatttc ccactgcata catctgaaaa
     2161 agttctctag cttctttcaa tcgcattatt ttctcttttc ccttatattt agaataacat
     2221 attctacctt tttttataat tcttgcattt gtggcaataa aagctaatga atgatccttt
     2281 tttattatgt taagcattgt cctaatcata tcaggatgca ttacatcatc atcatgaaat
     2341 atcataaaat attcactacg gacttctgac aaaactttat tccagtgttc tattaaacca
     2401 tattctcttt ctcttttccg ataaataata ttagattgat ttaaatagag agattctacc
     2461 atttctttcg tttcattgtt tgtagagtta tcagaaacaa tgattggaaa attagagatg
     2521 gtctgattta gtacagaatt taatgccagt tttaataaat gaggacgatt acgagtaatc
     2581 aaaaacaatg aaaaagtatc catatcttat ttcagtatat attggattgt atcttctggt
     2641 ttgtataact gatcagtgta tgcaatcaca ataaatggaa cactatctat atttataaac
     2701 tcatgtgcta tatgtggagg gacaaacacg gtaacaggct cttgatcatt caaataaatt
     2761 tccttttttt cattagtccg aatatcttca agttttaaaa cagcgtttcc ctcaaccaaa
     2821 gtaaaccatt caatcgctct attatgataa tgtcctccac gagattcccc tgatatggca
     2881 ctcacgatgt atatttcacc tgtataatta ggtaatgaat tttcttttcc atcaattatc
     2941 tttaaaaacc atcccctatt atctgaaatt tttcttcgag agattatctt gattttggat
     3001 tctatattta tactactcat gatatatatc tgttatctta attataggag aataatgtat
     3061 agccttgtaa agtttggcat cattcaatga gagtgataat atatcattgt ctcttcttaa
     3121 ttcttttcca aacatgtgtt catctacatc tacacaaaaa gcattgaaaa gttcttctat
     3181 gaattccctt attgtagctg tctgaccacc accaatattg tatattccac ttactacttc
     3241 accttcaata catttaaaaa tagcctctat cacttcttct ataaacacat actgtcgaat
     3301 ctgagaacca gaagaaaacc gaggttgctc aactttatta catttttttc tctctctcag
     3361 ataattaaca acataaggta acaatcttgt tccaacttca tctcttgaga agagattagg
     3421 taaaacaaag tgatattttc taaaaacgaa atttgcatta tgtatataat gtgtaaaaag
     3481 ccgtttagaa aggacataat cattagttac aggaagacaa gaatgcaaaa gttcatcttc
     3541 attaaatgat ttatacattt catcattaca tccaatctcc atataagttc caaaagatac
     3601 aaaagtcccc agataattat gctcattcaa taataaacag agttttatag gtaccagcaa
     3661 attcattgta tacattgtat ttgccgctat tggcactgct gcttgtacac ccgctcccgc
     3721 tgcatatata ataacatctg aatctaataa ctccgtaata taaacggcat cctctaaaag
     3781 attttttctt ataaatacat caggagcaaa tgctacagga gaactcttac cgataacctg
     3841 aataaaatag ccaacttttt tcaaaacagt tccaatgcta ttcgaaagca ttccacttcc
     3901 tcctcctata atagttattt tcatcggata tacttttcta tttgctccac acaaacttta
     3961 tacatttctt ctttttgata tcttctatac caatctacag tcaatcttac tgtttgatca
     4021 atattcattc ttggctccca gcccagttgg aattttactt tagaaatatc cagcattaat
     4081 aaatcagcct catgtaaagc attcgggtca gacaaatccc ttaattcacc acatccaaaa
     4141 ctctccacga ccctactagc aacatcccat acggtagaaa tagattctgc tctaggacca
     4201 aaattccaac cttcacaata ttgagtcggc tcatcccaca ttttctgtgc aagaagcata
     4261 tatccactca gaggttcaag tacatgttgc caagggcgaa ttgctttagg acttcgaata
     4321 tcaacagtcc ttcctgcttc taaagctttt atacaatctg gaattatgcg gtctaatgcc
     4381 caatcaccac caccaattac atttcctgcg cgtacactag cgatgctttt accatgcttc
     4441 ttgtactgtt taggatgaaa gaaagagcga cgccaggaag caatcgctat ttcagcagct
     4501 cctttactac ttgaataagg atcgtatccc cccatcggtt cattttcacg atatccccaa
     4561 atttgttctt tattctcgta acatttgtcc gtagttatca ttactcctac tttaacacta
     4621 tttgttacgc gaatggcttc aagtatatga atcgttccca ttacatttgt ttcatatgtt
     4681 tcaacaggaa tattataact gagacgtacc aatggttggg ctgccaaatg gaagactatt
     4741 tcaggttggt attcttgaaa gatacctttc atactttcgc catcacaaat atcggcacga
     4801 atatccgcct taattttttg tcctatacca gaaagaacat agttatctcg ttctgtaata
     4861 ggatccaaac tgacacctac cacttcagca cctaattcgt ataaccagat agaaagccat
     4921 gaacctttaa aaccagtatg gccggtaaca agaacccgtt ttcctctata gaagttatta
     4981 aatacatcta cactcatata ctaccaaact ttccaagggg ctttcccatt attccacatt
     5041 tcattcagtt ctatattatc ccttaacata tccatcggct tccaaaagcc acagtgttta
     5101 taagcataca ttttaccatc gcgggcaatc gattctaacg gttgtttttc aaagacgata
     5161 gaatcatcat tagcaggtat ataatcaaag acttttggtt cacaaacgaa aaagcctgca
     5221 tttatccagt ttccatcacc atccggtttt tccaggaatg atttcaccat attcgtctca
     5281 ctagatatat ctaataagcc aaattttccg tgaggtttat aagctgtaag agaaagaatt
     5341 gcttttgatt ctttgtgcac ttttatcgta tcagatatat caagatctgc aacaccatca
     5401 ccataagtca acaaaaaaca ttcatttcct acatatttct ggatgcgttt tacacgtcct
     5461 ccagtcattg tattcacccc agtatctatc atagttactt tccagttctc tgaatgatta
     5521 tctaaaatag tagtgctatt attagataga tcaactgtca tatcacaatt atgacgaaaa
     5581 tagtttgcaa aatattcttt tatgacatat tgtttatagc cacagcaaat aataaattca
     5641 ttaataccat aataactata aattttcata atatgccaaa gtattggctt tcccccaatt
     5701 tccaccattg gcttaggtat caaattagta gcctcactta aacgagatcc gaaccctcct
     5761 gctaaaataa cagctttcat agattagtaa tatttttaat taaagaaaat gcctctctca
     5821 tcacctcaaa gaacctctca atatcctcca catcaatctc tcccaacgca caaagccgga
     5881 atgtattcgt tgtggaaatc ttacccgggt agatcgtaaa gccacgttca tagcagtaat
     5941 catgaacctt atcaaaatcc cagaggggat catcaggata caatacagaa acaacaagac
     6001 ccgactgcca ttcacgtttg atcgcatact gaagaccaag ctcttgcaaa cctttatgga
     6061 tggcttcaaa gaccctcttg tgacgggcga atttagcctc ttcacctact gcaaaatatt
     6121 catcaagagc ctgacgggca gcgtaaacgg tttgaacagg aggagtaaaa tgcatctcac
     6181 ccgtcttctc aaagtaatcg tattgtaaat agaggttaca atagtaggag cgtttcggat
     6241 aatcccttga agcacgtatc agggattcat cacctatgat aaaggaaagc cccgtcatgg
     6301 cctgaaggcc tttctgagcc gaagccatac aaaagtcaac attatccttt ccgatatcaa
     6361 aaggaatcat acccagggag gaagtggtgt cgacaacaaa aacggcaccg tgcgaatggg
     6421 ctatttttcc gatctcacgg atggggttca agatacccgt acccgtttca tggtgcgtgg
     6481 tatagaccaa agcgatgtcc ggattgtcgg aaagcgtctt ttcgattacc gacaggtcgg
     6541 gaagttcgta aacggaaaac ttcaaatcga tatggggaag accgtaatat tcgcagactt
     6601 ccaccgcacg ggtgctgtag gcaccgttat tgacaaccag aactttctta tccgcaggaa
     6661 gaagagagtt caggcagata tcgatattga tcgtacccga gccgcaaaac aggacggccg
     6721 tatgtttgga gaggtctcca tgcgcaacgc ggaccaggtc gtcacgtaac tgtttcatca
     6781 tacccgcaaa ctctttctca cgcggacaga tatcgggaac aacctgcgcc agcttcaccg
     6841 tatccgtcgt ggtggcggga cccggattca aaaggatctt tctttcgata ttcatgaatg
     6901 cgtatctttt aaaaatgcca taaaatgctc tttattctct accggagtag tcgtagggcg
     6961 acccagatca tcacgtgaat cgatccggac cttaatttca agaagaaccg gaccggacag
     7021 gccggacagc ttctcaagcg cacacgaaag cccttccttg tcggaggcag tcagtacatg
     7081 cgcataaccg caacctttcg ctatcgaggc gatatccaga cggaaaccga gcgtgggttg
     7141 accgccgaca gattcatggg caccgttgtt gaaaaggacg tgcctgtaat tcttgggaga
     7201 aagatcgccg atattgctga cagcacccat gtgcatgata aaggcaccgt caccgtcaag
     7261 acagtagaca cggcggtcag gcttctcaag ggcaaccccc agggcaatgg aagaactgtg
     7321 ccccatggaa cccacagtta ggaaatccct tgcgtgcccc tgccctttcg attcacggta
     7381 ctcgaaaagc tcacgggaga gcttgcccgt ggtggaaacc acaatgtcat tgtccccgag
     7441 gtggtcgaca acctgcatta gcgcctcctc gcgggacaga ggatagtcat tcaaggcttc
     7501 ctgacgcaat ttatattttc caaacgtatc tttacggatg acaatcgcat ggggaatcga
     7561 ccggctcttc gccgagacaa ccgcgtcatg gatctgcgcc agggcctcgt cttcatccgt
     7621 atccagaatt ataaaaggaa ttttcatggc tttcagaaga tcaagggtaa cctcgccctg
     7681 cttcttatgc tggggttcgt cttttgtgcc gggctcaccg cgccagccga ccagcaaaag
     7741 aagaggaagg ctgtacactt tctcgtccgc aagggacaag aggggattca ccgtatttcc
     7801 cagaccggag ttctgcatat aaaccaaagg aacgttgcca gaagccatat aataaccgca
     7861 ggcaatgccc accgcggaac cttcattggc ggcgatgata tgcttaccac gcggagcatg
     7921 atccgtgata taggcgcaaa tattcttcaa aagggaatcg ggaacacccg taaagaagtc
     7981 aacaccgtga tgaaggaacg tatcgtatat cttttctaca cttaccataa ccgtctgatt
     8041 tatttagtgc ccggaatcaa ttccagaatt tccttgatag gcatacaaag cggacggacc
     8101 tcctcggcgc gctcgttttc aaggatggtc ctggccacgt tcatcatggc cgggtaagcg
     8161 gcacggagaa ggtggttggc gtaaatgact acgttggcac cccattcgtg aagttcggat
     8221 tcgtgcacat ggtcataagt cgtcggaaca acgacaatgg gaacatgggc gtattctttg
     8281 cggaaagtcc ggcagaactc acggatatcc tcacccgact tatccttgct gtggatcatg
     8341 atgccgtccg cacccgcctg tacataggca taagcacgtt cgagggcgtc actcatgggt
     8401 ttgccggcaa taaggctttc gatacgcgca atgatcataa agtcaccggt gacctgggca
     8461 ttcttccctg ctctgatctt atcgcagaaa ccctcgatac tatcctgagt ctggatagcg
     8521 tcagtaccaa aaagggaatt cttcttcaga ccgactttat cttcaatgat taccgcagaa
     8581 atgccgtgac gttccagagt gcgcacagta aagacaaagt gttcgatctt gccacccgtg
     8641 tctccatcaa aaataatagg cttggtggta cattcaagga tattgttcag gtcctgtaaa
     8701 cgggtggtaa ggtcgaccgc ttcaatatcc ggtttaccct tactcgtgga gtcggtcagg
     8761 ctgctggacc acatgccgtc aaagacctcg cgcttatcac ccttctggac ttcaagattc
     8821 tcaataatca gaccgcaaag accgtcgtga gcctccagga tacggaccac aggcttggcc
     8881 tggatcaggc ggcggaggga cttaagacgt acgtcagggg tagtcccgat cgccttgata
     8941 tccttgtcga gcgaggagga gttgatgccc cgggtataag ggatctcgat taccttgccc
     9001 ccctgggcgt tcatcacctc aaaaacctgt tcgcgcacct cgcgcaacgg gcccgttttc
     9061 cagtcgtcgc cgtggatgat atagtcaggc ttgagttttt ccagattcgg aacatagctc
     9121 cagtcctcct ggggaacaac ctcaaaaacc cccttgatat tctcaacaac ctccttacgc
     9181 tgatcatagg taaggtaagg gaggcgtttg tgttcggcga tggccttgtc cgtcagcaga
     9241 ccgacgatga catcaccgta tttagtagct tcatgaataa tatggatcag ccccggatgc
     9301 atgatatccg cggtcatacc gacatagatt ttcttgttca tatatggaaa agatttgttt
     9361 ttaacaatag cggatgatgt gctcctcggc atacgaaagg tcggcttcat catcgatttc
     9421 ataccattta agaccctcca ccctgagcac acggacaggg gaaacggaac gggacatgcg
     9481 gagcagttcg tactcgtaac ccagtttagg ctgggactcc aggatggtcg cataatcggc
     9541 gcacatccgg cggtagaaag tattggaaag tttatggata ccgaccagct cgccttttgc
     9601 ctcaagggcg ttcttgtcta ccgaacagga agtaaggatg tgattgcggt catattccac
     9661 ataatactga tcctggaact tggtcagaga agagacaagc atcacatccg ggaattcgtc
     9721 atccagtagc gagaggatgg ccttgcgttc aaaaacaagg tccgattcaa gcagcaggaa
     9781 actgtcatcg cctatcacgt cacgcgtatt gtacagagtg tacatactgt tagtatcggc
     9841 ataacgggga ctgaaacagg tctctatctg ggggaaatcc gcctgaaggg cttcataagc
     9901 ctctttttta taacccgtac cgaggatgat acgttcgata ccgcaggaaa gaagggtttc
     9961 gatagagcgg ataatcatag gttttccacc aacctccaca aaacctttgg gcacaagctc
    10021 ggtataatgc ccgaagcggg taccaagacc ggcagccatg atcattgctg ttttaatcat
    10081 gaatttcaga gggaattaat ataagtgaat tcaattgttg cttgaaataa cagtaaatcg
    10141 caaaaatcga caggacagaa acaaatcctg aaaaaagggc agtacgcatt agcatgacag
    10201 tccaagaaat gtcagcagaa acgaagttct tgaccataaa cacacccgta gtgcccagat
    10261 agccgaaaga atcggccaaa taaataataa aaacagccgt actaaccacc ctaagggaag
    10321 caatcaggcg ttctatcagg taagtgaaag gaatataccc catatacaga ccaagaccgg
    10381 aaagaatcat ccaccaaata ggagaaagaa aaccgtacac ataaagcaat gtggaaaaaa
    10441 ccattaagga accgcctgta acggcaatgc aataaatgat attaagagcc aaacggttat
    10501 tacggacaaa cacaatcagg aacatcagta caaggacaaa aacggcaatg ggaacctctg
    10561 tctgagtaaa gatcattgca ccttcaatat ggagctcctt ccaaatatcg gcagcgaaag
    10621 agtcacgaag ctcacggaac acggtcaggg caccgtaaaa aacaaccagc atgcagattc
    10681 cccagaagaa ttgcctcaaa aatttacgcc tgtctttacc atccatcgga gcacgtttgg
    10741 tacgctgtat gatatcttgc tcattgggag ccggaatctg attgagaagc cagctgcaaa
    10801 gcaacataac agggtatacc aacaaaccgg tggtaaaagg catccaatat tccgacacat
    10861 gcaaattatc catcacgaat tgtcccaagg ttttcaccaa accggaagag actatcaaag
    10921 caacgctcag cccgacattc aatatttcac tgatacgacg tccttcgata tagctaaaaa
    10981 tgacacccca gatcataccc aggggaagac cgctcagaaa aatagaacac accttcaaag
    11041 gaaccggaag aagtgcaaaa cccaacaaag caacttcgga aaaagtaagc agccctatta
    11101 tataatagat gcggtgaccc gctttcatcg aaggcagaat acgaacaccg atgaacttgg
    11161 aaagggcgta gccgataatc tcagaaagga catacaggat tttgacatcg aatccccaaa
    11221 gaatctcacc ttcataaatg gctgcggtaa atggcttacg gtaggcatag gcacaagtat
    11281 aaaccagaaa aatcaaaacg ctggcataga gagccaaaac gtaaagggga gaacgggaaa
    11341 gaaaggaacg aatcattcgt gtagttcgct gtacggatat ggattagctt ccaaa
//
