LOCUS       c00157_gnlPro..        13262 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|MLJHEGKN_190.
ACCESSION   c00157_gnlPro..
VERSION     c00157_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-03 18:11:29
            Original ID  :: gnl|Prokka|MLJHEGKN_190
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13262
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13262
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[303:3262]"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      304..3262
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
     cand_cluster    1..13262
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /kind="single"
                     /product="Pyruvate2acetate-formate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13262
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Pyruvate2acetate-formate"
                     /region_number="1"
                     /rules="((PFL_acetate1 or PFL_acetate2) and Radical_SAM)"
                     /tool="gutsmash"
     CDS             304..2532
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: PFL_acetate1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Gly_radical"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg157_1"
                     /sec_met_domain="Gly_radical (E-value: 2.2e-46, bitscore:
                     148.8, seeds: 99, tool: rule-based-clusters)"
                     /sec_met_domain="PFL_acetate1 (E-value: 0.0, bitscore:
                     1167.1, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELNKTFKDGLWSKEINVRDFVSNNITPYEGDASFLQGPTERTKA
                     VWNHCLKALEEERNNNGIRALDYTTVSTITSHPAGYIDKENELIVGLQTDQVLKRAIKP
                     FGGINVVMKACRENGVEVDDRVKDIFTHYRKTHNDGVFDVYTEEIRSFRSLGFLTGLPD
                     NYARGRIIGDYRRLALYGLDRLIEAKKEDLHNLTGPMTEARIRLREEVAEQIKALKEIK
                     VLGEYYGLDLSRPAYTAQEAVQWVYMAYLAAVKEQDGAAMSLGNVSSFLDIYLEYELSQ
                     GTITETFAQELIDQFVIKLRMVRHLRMQSYNDIFAGDPTWVTESIGGRFNDGRTKVTKT
                     SFRFLQTLYNLGPSPEPNMTVLWSPELPEGFKAFCAQVSIDTSSVQYENDDLMREVRQS
                     DDYGIACCVSYQEIGKQIQFFGARANLAKALLLAINGGRCENTGTVMVKDIPVLTGETL
                     KFEEVMANYKKVLIQIARVYNEAMNIIHYMHDKYYYEKAQMAFVDTDPRINLAYGVAGL
                     SIAIDSLSAIKYAHVKARRNDIGLTEGFDIEGAFPCFGNDDDRVDHLGVDLVYFFSEEL
                     KKLPVYKNARPTLSLLTITSNVMYGKKTGATPDGRAKGIAFAPGANPMHGRDKNGAIAS
                     LSSVAKLRYRDSQDGISNTFSIVPKSLGATQEDRIDNLVTMMDGYFTKGAHHLNVNVLN
                     REMLQDAMEHPEKYPQLTIRVSGYAVNFVKLSREHQLEVISRSFHERM"
     CDS             2537..3262
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: Radical_SAM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1015:4Fe-4S single cluster domain (Score: 72.3;
                     E-value: 1.6e-22)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg157_2"
                     /sec_met_domain="Radical_SAM (E-value: 3e-30, bitscore:
                     97.8, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINVHSYESMGTFDGPGLRLVVFLQGCNFRCLYCANPDTIEAKGG
                     TATDPEEIVRMAVSQKAFFGKKGGITFSGGEPTFQAKSLIPLFKRLKEAGIHICLDTNG
                     GLWNNDVEELLELTDLVLLDIKEFNPEHHQSLTGRSNEQTLKTAAWLETNHKPFWLRYV
                     LVPGYSDFEDDIRQLGEHLGTYQMIQRVEILPYHTLGVHKYEAMNKEYMLKGVKENTPE
                     QIEKAEKLFRQYFQTVQVN"
     CDS             complement(3494..4753)
                     /locus_tag="ctg157_3"
                     /transl_table=11
                     /translation="MKEDEKWIKAFKDKLEDYSEPMPASGWERLERELMPVTEKRIYPY
                     RRWAVAAAAVVLVVTTAVSLYFLNSPVADEIRYATAPSLAVNPDVLPEPALPDVQVAVS
                     EPVKPVGTTSINPVSGYLAKNTDPVIVPEVSSLVEKRPEAVTEEKRSEPQQEAIAAIEK
                     KESATAQPPKRKEARRPSGKDKYQLPIGDSSAKRGGKWSMGVGIGNGGGLPTNGSENFA
                     PRPMTNRVDLMTIMNGAVSIPADQEVIFEEGVPYLKSNTTAVVDYEHHQPVSFGLSVRK
                     SLPKGFSVETGLTYTLLSSDIKRQGDTKMQSQKLHYIGIPVRGNWNFLEKKYFTLYVSA
                     GGMVEKCVYGKLADDKVNVKPLQFSVAGAVGAQFNATDHVGLYVEPGVSYFFDDGSKVQ
                     TIRKERPCNFNLQAGLRFTY"
     CDS             complement(4808..5356)
                     /locus_tag="ctg157_4"
                     /transl_table=11
                     /translation="MNELELSERCRQGDNRARKELYEQYAGRMLGVCLRYAGDRDMAQD
                     LVHDGFLKIFDSFDKFTWRGEGSLRAWMERVMVNTVLQFLRKNDVMNQTTALDEVPETY
                     EEPDASAVEAIPQKVLMQFINELPAGYRTVFNLYTFEDKSHKEIAQMLGINEKSSASQL
                     FRAKSVLAKKVKEWLVTNG"
     CDS             5544..6296
                     /locus_tag="ctg157_5"
                     /transl_table=11
                     /translation="MKKFNLITFAVILMLLPILQSCLDDANNDEWVTCPPGGILAIGTM
                     KIPNADTPRDFFIALDNGDNVLPADTADIRNRKYTVAEGQRVFVGYLQMGEEKPGYENG
                     KIFTIEDILTKEIIPLTEATADSIGDDRINVTAHALTKDYLTIEYQYLGSMNENKKHML
                     NLVQNEITGPIKDDGYIYLEFRHNAFNDSPNQLGSSLVSFKLDSIAEQLATAKGIKLRV
                     NTIYDNIQYVTIDINEDKNLKIKSFHSQ"
     CDS             complement(6401..7327)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HTH_1"
                     /gene_functions="regulatory (smcogs) SMCOG1012:Bacterial
                     regulatory helix-turn-helix protein, lysR family (Score:
                     -3.4; E-value: 35)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg157_6"
                     /sec_met_domain="LysR_substrate (E-value: 8.8e-47,
                     bitscore: 151.1, seeds: 361, tool: rule-based-clusters)"
                     /sec_met_domain="HTH_1 (E-value: 4.1e-18, bitscore: 57.2,
                     seeds: 1330, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIQQLEYILAVDQFRHFAKAAEYCRVTQPTLSAMIQKLEDELGV
                     KLFDRSMTPVCPTAIGKKVLEQARKILSEVICVKEIISEEQHSLSGTFRLAVLPTIAPY
                     LLPRFFPQLMEKYPDLDIRVMEMKTPDIRKALLTGEADAAIIASMLDDAALTEETLFYE
                     QFLGYVSKKEPLFKHDVIRTSDVTGERLWLLDEGHCFRDQLVRFCQMEAVKISQMAYRL
                     GSMETFMHMVESGKGITFIPELAVMQLSEEQKELVRPFAIPRPTRQIVLVTRKDFIRTS
                     LLQVLKEEIQAAVPKEMLTLQAVQCLV"
     CDS             7469..7942
                     /locus_tag="ctg157_7"
                     /transl_table=11
                     /translation="MKTLNYTHLEEKGANTIVLSLQQLLADFQIHYANLRGFHWNIKGH
                     GFFVLHSKFEDLYNGAAEKVDEIAERILMLGGTPANKYSDYLKMAQIKEVDGVNKADDA
                     LNHILETYGHLIAEERKILSLASSHNDEVTVAMMSDYLKEQEKMVWMLTAYNG"
     CDS             complement(8046..9044)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glyco_hydro_130"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg157_8"
                     /sec_met_domain="Glyco_hydro_130 (E-value: 1.4e-69,
                     bitscore: 226.4, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEEIKIAGAALPAMPWEERPAGCKDVVWRCSANPIIPRDLLPTSN
                     SIFNSAVVPFKDGYAGVFRCDDTNRRMRLHVGFSKDAVHWDINEEPLKFQCDDAEVGTW
                     VYGYDPRVCFIEDRYYVTWCNGYHGPTIGVAYTYDFVTFHQLENAFIPFNRNGVLFPRK
                     INGRFAMLSRPSDNGHTPFGDIFYSESPDMEFWGRHRHVMSPAPFEDSAWQCTKIGAGP
                     IPIETSEGWLLIYHGVLASCNGFVYSFGSALLDIDQPWKVKFRSGPYLISPQKDYECMG
                     DVPNVCFPCAALHDSETGRIAIYYGCADTVTGLAFGYIPEIIEFTKRTSII"
     CDS             complement(9099..10367)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg157_9"
                     /sec_met_domain="MFS_1 (E-value: 3.9e-11, bitscore: 34.4,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKKPISPVCWVPTVYFAMGLPFVALSMVSVLMFSDMEVSNAQIA
                     FWTSLIMLPWTLKPLWSPFLEMFKTKKYFVVATEIITGLAFALVALSLPLPDFFRYAIA
                     LMGIIALSGATHDIAGDGVYLTELTATQQAKYIGWQGAFYNLAKILANGGLVWLAGMLK
                     DEFGVVHAWMIVMLMCAGIMILIGLYHIRILPSGGGASGEVNTMSDALNMLWEVIRSFF
                     QKKHIAFYIVFIILYRFAEGYAIKIVPLFLKASVADGGLGLSTQDIGLVYGTFGAGAFI
                     LGSLLAGYYISAFGLRKTLFSLCCAFNIPFLVYFLLALYQPSDLWIIGMAIVSEYLGYG
                     FGFVGLMLFMMQQVAPGKHQMAHYAFATGIMNLGVMLPGMMSGYLSDWLGYRDFFIWVL
                     IATIPAFIVTWLVPFTYPDGKKK"
     CDS             complement(10617..11630)
                     /locus_tag="ctg157_10"
                     /transl_table=11
                     /translation="MNRHLNFVTLICLITGFVSLASCSNDDDEMDKYQKIYIRTGVAPG
                     AEMGAAVVVDCVSNSSTADRSDFEIQLCAVQPVTRDVTAALGVDTLKVDTYNSANKTKC
                     KLLPQDNYTIETSEVVLKTGQTVADSSFQVVLKNIEKLTNPDGYVLPVTLKGVTGMDEQ
                     AVSTSMKTVYIRIYTSVLYTSYTKPGNWSAVDRSAWSVSCSNVYADDDAKYGAHLAIDG
                     EINTTWFTWGVANAGECWWNTVLDRPVTLTGFSVTKQSAYGSGYNLRSAEIKVRKEGET
                     EWVTYPRVLTFRNFKGADPQYAAIEPPIPNVKEFRINCLTPDNYTGFAEINLYVKQ"
     CDS             complement(11653..12789)
                     /locus_tag="ctg157_11"
                     /transl_table=11
                     /translation="MKRITIKQCLLACFVLPMILAGCNDADYQVIDNAIYLNEASENGS
                     AKVTVDPENVTTTTLTVRVGQPVTENVTAVLTVDPSILKEYNEANETSYEVLPEQYFTY
                     DKEIKIAAGDVSAIPSEFRVKPYSNENGELYAIPVSLTEIQGPVSTIGLSSKFIILLDK
                     PLIQSVPFMNTTNAVKPAKDELWGVTTNEWSLEAWVQMDGFDINNQAIFNSGSSDHEVY
                     IRFGDAMIPYNSLQVKTLGSQVNTVTLFEKNKWYHLAFVYNSSGLLSIYINGVLDVTLQ
                     TKGGPVRFDKMNMVSSGSYFRNNCQMAQVRLWKSAISQTQIQSNMYFAVKPADPNLIGY
                     WKMDEGKGNAFADCTGHGYDLVAGGTLVWKEHVRFDKQ"
ORIGIN
        1 gtacaacggt tttcaagacc gccgcaatcg accactctgc cacctctcca gaactacggt
       61 taagtagtgc ttttctctta aagcgctgca aaggtacgaa tcatttttta acttgcaaat
      121 tattccgcaa aaaaatatta gaaaagtata tttggaagta ataactgcta tctggcttct
      181 ccccataaat aggtattttt atgctattca acataaaata ggaccctttt atatacctaa
      241 accgaaaaaa ggttgtaaat ttgcgcgctc taaaggataa ctaaccacta actgattaat
      301 tttatggaac tgaataagac ctttaaagat ggactttgga gcaaagaaat caatgtaagg
      361 gatttcgtta gtaacaacat cactccttat gaaggggatg cttctttcct gcaaggacct
      421 accgaacgca ccaaagctgt ctggaatcac tgtctcaaag ctctcgaaga agagagaaac
      481 aataatggta ttcgtgcact cgactacaca actgtatcta ctataacctc tcaccctgcc
      541 ggctacatcg ataaagaaaa cgaactgatc gtcggactac agaccgatca ggtgttaaaa
      601 cgtgccatca aaccgtttgg cggaatcaat gtggttatga aagcttgccg tgaaaacgga
      661 gtggaagtag atgacagagt taaggatatc ttcactcact atcgcaagac tcacaatgat
      721 ggggtattcg atgtgtatac cgaagaaatt cgttcgttcc gttccttggg attccttacc
      781 ggacttcccg acaactatgc acgcggacgt atcatcggtg attatcgccg cctggctctc
      841 tatggtcttg accgtctgat agaagctaaa aaagaagatc tgcataatct gacaggtcct
      901 atgactgaag cccgcattcg tcttcgcgaa gaagtagccg agcaaatcaa ggccctgaaa
      961 gagattaaag tattgggcga atattatggt ttggatctga gccgaccggc atataccgca
     1021 caggaagctg tacaatgggt gtatatggct tatctggctg ccgtaaaaga gcaggatggt
     1081 gctgccatgt cactgggtaa tgtatcttca ttcctcgaca tctatcttga atatgaatta
     1141 agccagggta cgataaccga aacattcgct caggaactga tcgaccaatt cgttatcaaa
     1201 ctccgtatgg tacgccactt gcgtatgcag tcgtacaacg atatttttgc gggtgatccc
     1261 acatgggtga ccgaatctat cggtggacgt ttcaatgatg gacgtaccaa agttactaaa
     1321 acttctttcc gcttcttgca gacactttat aacttaggcc cgtcaccgga acctaacatg
     1381 actgtactat ggagccctga gttacccgaa ggtttcaaag cattctgtgc acaagtatct
     1441 atcgacactt cttccgtaca atacgaaaac gacgacctga tgcgtgaagt ccgtcaatcg
     1501 gatgactacg gaatcgcttg ttgtgtttca tatcaggaaa tcggaaagca gattcagttc
     1561 ttcggtgcac gtgccaacct tgccaaagcc ctgctactgg ctatcaacgg aggacgttgc
     1621 gaaaatacag gtacagttat ggtaaaagac atccctgtat tgaccggtga aacactgaag
     1681 ttcgaagaag taatggccaa ctataagaaa gtattgatac aaattgcacg tgtatacaac
     1741 gaagcaatga atatcataca ttacatgcac gataagtatt actacgaaaa ggcgcagatg
     1801 gctttcgtgg atactgatcc ccgcattaac ctcgcttatg gtgtagccgg actttcaatc
     1861 gccatcgatt cactgtccgc catcaaatat gcacatgtga aagcccgtcg caacgacatc
     1921 ggactgacgg agggattcga tatcgaaggt gctttccctt gtttcggtaa tgacgatgac
     1981 cgtgtagacc acctgggtgt ggacctggta tatttcttta gcgaagaatt aaagaaactc
     2041 cccgtatata agaatgcccg tcctaccctt tcgctgctga ctatcacttc gaacgtaatg
     2101 tatggcaaga agaccggtgc cactcctgac ggacgcgcca aaggcattgc ctttgctccc
     2161 ggtgccaacc ccatgcacgg acgtgataaa aatggtgcaa tcgcctcact gagttctgta
     2221 gccaagttgc gttatcgcga ctcacaggat ggtatcagca atacattctc gatcgttccc
     2281 aaatcattgg gagcaacaca agaagaccgt atcgacaatc tggtgaccat gatggacgga
     2341 tattttacaa aaggcgcaca ccacctgaac gtaaacgtgc tgaaccggga aatgttgcag
     2401 gatgcgatgg aacatcccga aaagtatccg caactgacta tccgtgtctc aggatatgcc
     2461 gttaatttcg tgaaattgag ccgcgaacat cagttggaag taatcagccg cagtttccac
     2521 gaaagaatgt aattgaatga taaacgtaca ctcatacgag tcaatgggaa cattcgacgg
     2581 gccgggtctc cggctcgtcg ttttccttca agggtgtaac ttccgttgcc tctattgtgc
     2641 caatccggac acaattgaag ccaaaggagg gacagcaacc gaccctgagg aaatagttcg
     2701 catggccgtc agtcagaaag ctttcttcgg taaaaaggga ggtatcacct tttccggcgg
     2761 agagcctact tttcaagcaa aatcgcttat cccacttttt aaaagactaa aggaagcagg
     2821 aatccatatt tgccttgata ccaatggcgg gctatggaac aatgatgtag aggaactatt
     2881 ggaattgact gatctggttt tattagatat caaagaattt aatccggaac atcatcagtc
     2941 tttaaccgga agaagcaacg agcagaccct gaaaaccgca gcctggcttg aaaccaatca
     3001 taaaccattc tggttgcgat acgtattagt gcccggctac agtgacttcg aagacgatat
     3061 ccggcagctg ggagagcatc ttggaacgta ccagatgatt cagcgtgtag aaatattgcc
     3121 ttaccacacc ttgggtgttc acaaatatga agcaatgaac aaagaatata tgctgaaagg
     3181 agtgaaagag aatactccag agcagataga aaaggctgag aaactattca ggcaatattt
     3241 ccagaccgta caagtaaatt gacttatata agtgtcgaaa ttcgtattca ccacagatta
     3301 cacgaattta cacaaataaa gatcattggc aatcaataga ttaagttcat tctgcggtga
     3361 attatgacga ctgcacttat ttataatttt gtaagtcacg atataaaagt ctccctgttc
     3421 ttgccttaat tcattacaat acaaggcaag aacagggaga taatgtaacc ggcatatttt
     3481 ttgccatcct actttaataa gtgaatcgca atcctgcctg caagttaaag ttacaaggcc
     3541 tttcttttcg gatggtttgt actttggagc catcatcaaa gaaatacgaa actcccggtt
     3601 ccacatatag gccgacatga tctgtcgcat tgaattgcgc tcccacggca ccggctacag
     3661 aaaattgcaa aggcttcaca ttcaccttat catccgccaa ctttccataa acacactttt
     3721 caaccattcc tccggcagat acatagagtg taaaatattt cttttccaga aaattccagt
     3781 ttccacgtac aggaatacct atataatgca atttctgact ctgcatcttg gtatccccct
     3841 gccgtttgat gtcagaagac aacaacgtat aagtcaatcc cgtctctaca gagaaacctt
     3901 tgggaagaga cttacgtaca gacagtccga agctaaccgg ctgatgatgt tcataatcca
     3961 ccacggcagt tgtattggac ttcaggtaag ggactccttc ttcaaatata acttcctgat
     4021 cggcaggaat actcacagct ccattcatga tcgtcatcaa gtcgaccctg ttagtcatcg
     4081 gacggggcgc aaaattttcg gaaccatttg tcggaagtcc acctccatta ccgataccca
     4141 ctcccatcga ccatttacca ccacgtttag cagaagagtc tccgataggc aactgatact
     4201 tgtctttacc ggacggtcgc cgcgcttctt tcctctttgg aggctgcgcc gtcgcacttt
     4261 cttttttctc gattgcagca attgcttcct gttgcggctc agatctcttt tcctccgtca
     4321 ctgcctccgg tcgcttctct accagggagg atacctccgg aacaatcacc ggatcagtat
     4381 tctttgccaa atagcccgaa acagggttaa tactcgtcgt tcctaccggc ttaactggtt
     4441 cggatacagc tacctgtaca tccggcaagg caggttccgg caatacatcc gggttgacag
     4501 ccagtgaagg agccgttgca taacggattt catcagctac cggactattc agaaaataca
     4561 aactgacagc agtcgttacc accaatacca cagctgccgc agcaaccgcc caccggcgat
     4621 acggatatat tcgtttttcg gttacaggca tcagttccct ttccagtcgt tcccaaccgg
     4681 aagcaggcat cggctccgaa taatcttcga gcttatcctt gaatgcttta atccattttt
     4741 cgtcttcttt catcattcta tttcattttt gaaatccaag gttcacctca gtatctgtaa
     4801 atacatgtca accattggtc accaaccatt ctttcacttt ctttgccaat acactttttg
     4861 cgcgaaaaag ctgtgaggca gaagattttt cattaatccc caacatctgt gcgatttcct
     4921 tgtgcgactt atcttcaaag gtgtataaat tgaatacggt acgatatccg gcggggagtt
     4981 cattaataaa ttgcatcagc actttctgtg gtattgcttc aacagccgaa gcatccggtt
     5041 cttcatacgt ttcgggaact tcatccagtg ccgtggtctg gttcatcacg tcgttctttc
     5101 ttaagaactg taaaaccgta ttcaccatta cacgctccat ccatgctctc agagagcctt
     5161 caccccgcca ggtaaacttg tcgaaggagt cgaaaatctt caggaaaccg tcgtgtacca
     5221 agtcttgtgc catgtccctg tctccggcat aacgaagaca gacaccaagc atgcgccctg
     5281 cgtactgctc ataaagttct ttgcgggcac gattatctcc ctgcctgcaa cgttccgaca
     5341 gctctaattc attcattctc ctaaacacgt gtttacctta taaatgcagc aaagatagaa
     5401 atactgcaca gagagaacaa ctcttttatc acttttgttt ctttaacatt ttaggatgca
     5461 atatttcatc acttcctgca ttttctcaat acaataaaga ataaatctca atggataaat
     5521 aggataaaac caacaagaaa cttatgaaga aatttaattt aataactttt gccgtcatcc
     5581 tgatgttatt gcccatttta cagtcatgtc tggacgatgc caacaacgac gagtgggtca
     5641 cttgtcctcc gggtggaata ttggccatcg gcacaatgaa gattcccaat gcggacactc
     5701 caagggactt tttcattgca ttggacaatg gagacaatgt acttccggca gatacggccg
     5761 atatacgcaa caggaaatac actgttgcag aaggtcaaag agtcttcgtt ggctatctgc
     5821 agatgggaga agagaaacct ggatatgaga acggtaaaat attcacgata gaagatatat
     5881 tgacgaaaga gatcatccca ctgacggaag ctacagcaga cagcattgga gacgaccgta
     5941 tcaacgtcac agcgcatgca cttacgaaag attatctgac catcgaatat caatatctgg
     6001 gcagcatgaa tgaaaataaa aaacacatgc tgaacttggt acaaaacgaa ataacaggtc
     6061 ccataaaaga tgacggatat atctatctgg agttccggca taatgccttt aatgactccc
     6121 ccaatcaatt gggttcgagc cttgtttctt tcaagctgga tagtatagcc gagcaattgg
     6181 cgacagccaa aggaataaaa ctccgtgtga acaccattta tgacaatata cagtatgtca
     6241 caatagatat caacgaagac aaaaacttaa aaataaaatc atttcattct caataaaaca
     6301 acaagaaaca cctacacaat caggcaaaac gagtaataat tctgatacat aaaagaaata
     6361 aggcggcgat gtttgtgaaa atatcgccgt cgtttttata ttataccaga cactgaacgg
     6421 cctgcagggt aagcatctcc ttgggaaccg ccgcctgaat ctcctctttc aaaacctgca
     6481 gcagactggt gcggatgaag tctttccggg tcaccaggac aatctgacgg gtaggccgcg
     6541 ggatagcaaa cggacggacc agttctttct gctcttcgct caattgcatc actgccagtt
     6601 cgggaataaa cgtaatcccc ttaccactct ctaccatatg cataaaggtt tccatactac
     6661 ccagccgata cgccatttgg ctgatcttaa ccgcttccat ctgacaaaaa cgaaccaact
     6721 gatcgcggaa gcaatgccct tcgtcaagaa gccaaagccg ttcccctgtc acatcggacg
     6781 tacgaatcac atcgtgcttg aacaacggtt ccttctttga gacatagccc aggaattgct
     6841 cgtagaataa ggtctcttcc gttaatgcgg catcatccag catgctggca atgatagcag
     6901 catccgcttc accggtcagc agagccttgc gaatgtcggg cgtcttcatc tccatcaccc
     6961 gtatatcaag atccgggtat ttctccatca gttgcggaaa gaaacggggc agaagataag
     7021 gtgcaatcgt cggtaacact gccaatcgga atgtacccga cagggagtgc tgttcttcgc
     7081 tgatgatctc cttgacacag ataacttccg aaagaatctt acgggcctgt tccagcactt
     7141 tcttaccaat ggcagtaggg caaaccggtg tcatgctacg gtcgaacagt ttcaccccca
     7201 attcgtcttc cagcttttgg atcattgcac tcaaagtagg ttgcgtcacc cggcaatact
     7261 cggcagcttt agcaaaatgc cggaactggt ccacagccag aatatattcc aattgttgta
     7321 tagtcatcgt tctctgattt attaaagata tagaatctat caatgcaaag atagaaattt
     7381 tcagtttgac acgaatcatt ttgtgccgta tctttgttcc agataaaaag aagaaatata
     7441 gtattaactc aaaaaaaaca atatcattat gaagacttta aattatacac atttggaaga
     7501 aaaaggagct aacaccatcg tactgtcatt acagcaactg cttgccgatt ttcagattca
     7561 ttatgcaaac ctgagaggat ttcactggaa catcaaagga cacggtttct tcgtactgca
     7621 cagcaagttt gaagatttat ataatggagc cgccgaaaag gtggacgaaa tagccgaacg
     7681 tatactgatg ctgggaggaa ctcccgccaa taaatacagt gactatctga agatggcgca
     7741 gatcaaggaa gtggacggag tgaataaggc cgacgacgct ctgaatcata ttctcgaaac
     7801 ttacgggcat ctgattgcgg aagaacgtaa aatcctgtct ctcgcctctt cacacaacga
     7861 cgaagtaaca gtggccatga tgagcgacta cctgaaagaa caggaaaaga tggtttggat
     7921 gctgactgca tacaacggat aacagccgaa agggtgtagc catctgaccg aaaaggtgta
     7981 gccatacaag caaaagggtg tagccatccc ggcgggatag ctacaccctt tctgttttat
     8041 tcgattcaga tgatacttgt acgtttggta aattcaataa tctccggaat gtatccgaat
     8101 gcgagcccgg tcactgtatc cgcacaccca taatagatgg caatccgtcc ggtctccgaa
     8161 tcatgaagcg ccgcgcatgg gaaacagaca ttaggcacat cacccataca ttcgtaatcc
     8221 ttctgaggtg aaatcagata aggccccgaa cggaatttta ctttccaggg ttgatcgatg
     8281 tcaagcagtg ccgaaccaaa actatacaca aaaccgttgc aggaagccaa tacaccatga
     8341 tagatcagca accagccttc cgaggtttca atcgggatag gccctgcacc gatcttggta
     8401 cactgccagg cactgtcttc gaacggagcc ggcgacataa catgacgatg acgtccccaa
     8461 aactccatat cgggagactc gctatagaaa atatctccaa aaggagtatg cccattatca
     8521 ctcgggcggc tcaacatcgc aaaacgaccg tttatcttac gagggaacaa gactccattc
     8581 cgattgaaag gaataaaggc attctccaac tggtgaaaag taacaaaatc ataggtgtag
     8641 gccacaccga tagtaggacc atgatagcca ttacaccagg tcacatagta gcggtcttcg
     8701 ataaagcaaa cccgtgggtc atatccatag acccaggttc caacctcagc atcatcacat
     8761 tgaaacttta acggttcttc gttgatatcc caatgaacag catccttgct gaatcccaca
     8821 tgcaaacgca tgcgacgatt agtatcatca caacggaaca cccctgcata gccatcctta
     8881 aacggaacta cggcactgtt gaatatactg tttgaagtag ggagcaagtc gcgcggaata
     8941 atcggattgg ccgaacaacg ccacactaca tctttacatc ctgccggacg ttcttcccaa
     9001 ggcatagccg gcaaagcagc acctgcaatt ttaatttctt ccatgattcg attaaattaa
     9061 tattatgtat atatcttgtt tatattgaaa atctcttttt atttcttctt tccgtccgga
     9121 tatgtgaaag gtaccagcca agtcacgata aaagccggta tggtagcgat aagtacccag
     9181 ataaagaaat cgcgataacc cagccaatcg ctcaggtatc cgctcatcat tccgggaagc
     9241 atcaccccca gattcataat accggtagca aaagcataat gtgccatctg atgtttgccg
     9301 ggagccactt gctgcatcat aaagagcatc aatccgacaa aaccaaaccc gtaacccaag
     9361 tattcagaca caatggccat accaataatc catagatcgg aaggctggta aagggctaac
     9421 aggaaatata ccaagaacgg aatattaaaa gcgcaacata aagaaaacaa agtcttccga
     9481 agtccgaaag ccgaaatgta ataaccggcc aaaagcgaac cgagaataaa agctcccgct
     9541 ccgaacgtac catataccag tccgatatcc tgagtgctga gtcccaatcc accatccgca
     9601 accgacgctt tcaggaacaa cggtacaatc ttgatggcat atccttcggc aaaccggtac
     9661 aaaatgataa agacaatgta gaaagcaata tgtttttttt ggaaaaaaga gcggatgact
     9721 tcccaaagca tattcaatgc gtcactcatc gtattcactt caccggaagc gcctcctccc
     9781 gaaggcaaaa tccggatgtg gtaaagaccg atcagaatca taatacccgc acacatcaac
     9841 atgacaatca tccaggcatg taccactcca aattcatcct tcagcatacc tgccagccaa
     9901 accaagcctc cgttggcaag tatcttggcc agattataaa aagctccctg ccaaccgata
     9961 tacttggctt gctgggtagc agtcagttca gtcaggtata ctccgtcacc cgcaatgtca
    10021 tgagtcgcac cactgagagc aatgatcccc atcagagcga tggcataacg aaaaaagtcg
    10081 ggcagcggca gcgaaagtgc taccaatgca aatgccagtc cggtaatgat ttccgtagcg
    10141 acaacaaagt atttcttcgt tttaaacatt tccagaaacg gactccataa aggcttcaat
    10201 gtccagggaa gcataatgag agaagtccag aaagcaatct gtgcattcga cacttccata
    10261 tcggaaaaca taaggacaga aaccatcgaa agggccacaa acggcaatcc catagcaaag
    10321 taaacagtag gcacccaaca tacagggctt atcggctttt tattcatcag ttagtttttt
    10381 ataataattc catcggttaa caattccagt aagcaaagat aggggatatt aaaaacataa
    10441 cccaagatta cgacaagaag ttgctttcat tatttaataa tacaactcac ccgggaaaac
    10501 tactaacctc tatcaccctt tttttattaa actttatcaa tacaatacac gcaaagaagc
    10561 accgaagact ttcatccccg atgcctctcg cccccttatc tacaatctaa acacctctat
    10621 tgcttcacat ataaatttat ctcagcaaac ccggtataat tatccggagt cagacagttt
    10681 attctgaatt cctttacatt cgggataggt ggttcgatgg ccgcatattg cggatcagcc
    10741 cctttaaaat ttctgaaagt caagactctc gggtaagtaa cccactcggt ttcaccctct
    10801 ttccgaacct taatctcagc acttctcaga ttataacccg atccgtaggc actctgttta
    10861 gtgaccgaaa atccggttaa ggtaacaggc cggtccagta ccgtattcca ccaacactct
    10921 ccggcattag ccactcccca tgtaaaccaa gtagtattta tctcaccgtc aatagccaga
    10981 tgtgcaccat atttggcatc atcatcggca taaacattgc tgcaacttac actccacgca
    11041 cttcgatcta cagcggacca attcccgggt ttcgtataac tggtataaag cacgctggta
    11101 taaatccgga tataaaccgt cttcatagat gtactgacag cctgttcgtc catgcccgta
    11161 actcctttaa gcgtcacggg aagcacatat ccgtcaggat tagtcaactt ttctatattc
    11221 ttcaaaacga cctgaaaaga tgaatcggcc actgtctgtc ccgtttttaa gacaacttca
    11281 cttgtttcaa tagtataatt atcttggggc aacaacttac atttcgtctt attggcagaa
    11341 ttgtaagtat ccactttcag cgtatctact cccaaagcgg cagtgacatc ccgcgtaacc
    11401 ggctgtacgg cacacaattg tatttcaaaa tcagaacggt cggcagtaga ggaattgctc
    11461 acacaatcca ccactaccgc agcacccatt tcggcccccg gtgcaactcc cgttctgata
    11521 tatatctttt gatatttgtc catttcatca tcatcgttgc tgcacgaagc caacgataca
    11581 aagcctgtta tcaggcagat taaggtcaca aaattcaaat gtctattcat atcttatctt
    11641 ctttttacat agttattgct tatcaaaacg aacatgctct ttccagacaa gagttcctcc
    11701 tgccaccaaa tcgtatccgt gtccggtaca gtcggcaaag gcatttcctt taccttcatc
    11761 cattttccaa tagcctatca ggttcggatc ggcgggtttc acggcaaaat acatgttgga
    11821 ctgaatttgc gtctggctga ttgcgctctt ccaaagacgc acctgggcca tctgacaatt
    11881 gttgcggaag tagctaccgc tcgaaaccat gttcatcttg tcgaatctta ccgggccacc
    11941 ctttgtctgc agagtcacgt cgagcactcc gttgatataa atcgacaata acccggaaga
    12001 attataaacg aaggccagat gataccactt attcttctca aacaaagtca ccgtattgac
    12061 ctgacttcca agtgtcttca cctgtaatga attataaggg atcatagcgt caccgaaacg
    12121 gatataaacc tcgtggtcgc tgctgcccga attaaatata gcctgattat taatatcgaa
    12181 tccgtccatc tgtacccaag cctcgagtga ccattcattg gttgtcactc cccacaattc
    12241 gtccttggcg ggcttcacgg cattggtcgt attcataaac ggtacagact gtatcagcgg
    12301 cttatccagc aaaatgataa acttcgacga aagcccgatt gtggacaccg gtccctgaat
    12361 ttctgtgaga gataccggaa tagcatacaa ttctccgttt tcgtttgaat aaggtttcac
    12421 tctaaactca ctggggattg cgctaacatc gcctgccgct atctttatct ctttgtcata
    12481 agtaaaatac tgctcgggaa ggacttcgta cgaagtttca ttagcttcat tgtactcttt
    12541 aagaatagaa ggatctaccg tcaggacagc agtcacattt tcggttacag gctgtcccac
    12601 acgtacggtc agagtagttg ttgttacatt ttcaggatca acggtaacct ttgccgaacc
    12661 attctcggat gcttcattca aataaatcgc attgtcgata acctggtaat cggcatcgtt
    12721 gcatcctgcc aggatcatcg gcagaacgaa acaggcaagc aaacattgtt ttattgttat
    12781 tcttttcata atcaaattct ttaaagtcat tttacagcag gattcattat tctgattgct
    12841 tcacgcaggt acttatattc gatgtcgccc ggatagtcat attccatgtg ataggtgcct
    12901 actccaccct tccgtacctg ttttccgtca atagtcggag tccagcgtgc catgccggca
    12961 agtgctctca ttttgtttcc gtaacgatct acataatcac ctcctcctgt cggagcataa
    13021 gattcgaaat tctccgtaac gatgtacata ttagccactt tctccggagg aagtattcct
    13081 ttaaagttgg caatcgtacc agccagacgt ctgtcaagat tagcgtcgga attacccgca
    13141 aggttagagt atgcctgcac aatgaaatag tcaaagtaag gcccggtttc cggatgaata
    13201 ctttgaggct cgccatcaat cacaagtaac cgtcccgtac ccgatttagg tccgattctt
    13261 tc
//
