LOCUS       c00036_gnlPro..        13266 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NOEMIMDN_44.
ACCESSION   c00036_gnlPro..
VERSION     c00036_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-03 17:57:25
            Original ID  :: gnl|Prokka|NOEMIMDN_44
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13266
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13266
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[307:3266]"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      308..3266
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
     cand_cluster    1..13266
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /kind="single"
                     /product="Pyruvate2acetate-formate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13266
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Pyruvate2acetate-formate"
                     /region_number="1"
                     /rules="((PFL_acetate1 or PFL_acetate2) and Radical_SAM)"
                     /tool="gutsmash"
     CDS             308..2536
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: PFL_acetate1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Gly_radical"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg36_1"
                     /sec_met_domain="Gly_radical (E-value: 2.2e-46, bitscore:
                     148.8, seeds: 99, tool: rule-based-clusters)"
                     /sec_met_domain="PFL_acetate1 (E-value: 0.0, bitscore:
                     1167.1, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELNKTFKDGLWSKEINVRDFVSNNITPYEGDASFLQGPTERTKA
                     VWNHCLKALEEERNNNGIRALDYTTVSTITSHPAGYIDKENELIVGLQTDQVLKRAIKP
                     FGGINVVMKACRENGVEVDDRVKDIFTHYRKTHNDGVFDVYTEEIRSFRSLGFLTGLPD
                     NYARGRIIGDYRRLALYGLDRLIEAKKEDLHNLTGPMTEARIRLREEVAEQIKALKEIK
                     VLGEYYGLDLSRPAYTAQEAVQWVYMAYLAAVKEQDGAAMSLGNVSSFLDIYLEYELSQ
                     GTITETFAQELIDQFVIKLRMVRHLRMQSYNDIFAGDPTWVTESIGGRFNDGRTKVTKT
                     SFRFLQTLYNLGPSPEPNMTVLWSPELPEGFKAFCAQVSIDTSSVQYENDDLMREVRQS
                     DDYGIACCVSYQEIGKQIQFFGARANLAKALLLAINGGRCENTGTVMVKDIPVLTGETL
                     KFEEVMANYKKVLIQIARVYNEAMNIIHYMHDKYYYEKAQMAFVDTDPRINLAYGVAGL
                     SIAIDSLSAIKYAHVKARRNDIGLTEGFDIEGAFPCFGNDDDRVDHLGVDLVYFFSEEL
                     KKLPVYKNARPTLSLLTITSNVMYGKKTGATPDGRAKGIAFAPGANPMHGRDKNGAIAS
                     LSSVAKLRYRDSQDGISNTFSIVPKSLGATQEDRIDNLVTMMDGYFTKGAHHLNVNVLN
                     REMLQDAMEHPEKYPQLTIRVSGYAVNFVKLSREHQLEVISRSFHERM"
     CDS             2541..3266
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: Radical_SAM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1015:4Fe-4S single cluster domain (Score: 72.3;
                     E-value: 1.6e-22)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg36_2"
                     /sec_met_domain="Radical_SAM (E-value: 3e-30, bitscore:
                     97.8, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINVHSYESMGTFDGPGLRLVVFLQGCNFRCLYCANPDTIEAKGG
                     TATDPEEIVRMAVSQKAFFGKKGGITFSGGEPTFQAKSLIPLFKRLKEAGIHICLDTNG
                     GLWNNDVEELLELTDLVLLDIKEFNPEHHQSLTGRSNEQTLKTAAWLETNHKPFWLRYV
                     LVPGYSDFEDDIRQLGEHLGTYQMIQRVEILPYHTLGVHKYEAMNKEYMLKGVKENTPE
                     QIEKAEKLFRQYFQTVQVN"
     CDS             complement(3498..4760)
                     /locus_tag="ctg36_3"
                     /transl_table=11
                     /translation="MMKEDEKWIKAFKDKLEDYSEPMPASGWERLERELMPVTEKRIYP
                     YRRWAVAAAAVVLVVTTAVSLYFLNSPVADEIRYATAPSLAVNPDVLPEPALPDVQVAV
                     SEPVKPVGTTSINPVSGYLAKNTDPVIVPEVSSLVEKRPEAVTEEKRSEPQQEAIAAIE
                     KKESATAQPPKRKEARRPSGKDKYQLPIGDSSAKRGGKWSMGVGIGNGGGLPTNGSENF
                     APRPMTNRVDLMTIMNGAVSIPADQEVIFEEGVPYLKSNTTAVVDYEHHQPVSFGLSVR
                     KSLPKGFSVETGLTYTLLSSDIKRQGDTKMQSQKLHYIGIPVRGNWNFLEKKYFTLYVS
                     AGGMVEKCVYGKLADDKVNVKPLQFSVAGAVGAQFNATDHVGLYVEPGVSYFFDDGSKV
                     QTIRKERPCNFNLQAGLRFTY"
     CDS             complement(4812..5360)
                     /locus_tag="ctg36_4"
                     /transl_table=11
                     /translation="MNELELSERCRQGDNRARKELYEQYAGRMLGVCLRYAGDRDMAQD
                     LVHDGFLKIFDSFDKFTWRGEGSLRAWMERVMVNTVLQFLRKNDVMNQTTALDEVPETY
                     EEPDASAVEAIPQKVLMQFINELPAGYRTVFNLYTFEDKSHKEIAQMLGINEKSSASQL
                     FRAKSVLAKKVKEWLVTNG"
     CDS             5548..6300
                     /locus_tag="ctg36_5"
                     /transl_table=11
                     /translation="MKKFNLITFAVILMLLPILQSCLDDANNDEWVTCPPGGILAIGTM
                     KIPNADTPRDFFIALDNGDNVLPADTADIRNRKYTVAEGQRVFVGYLQMGEEKPGYENG
                     KIFTIEDILTKEIIPLTEATADSIGDDRINVTAHALTKDYLTIEYQYLGSMNENKKHML
                     NLVQNEITGPIKDDGYIYLEFRHNAFNDSPNQLGSSLVSFKLDSIAEQLATAKGIKLRV
                     NTIYDNIQYVTIDINEDKNLKIKSFHSQ"
     CDS             complement(6405..7403)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HTH_1"
                     /gene_functions="regulatory (smcogs) SMCOG1012:Bacterial
                     regulatory helix-turn-helix protein, lysR family (Score:
                     -3.5; E-value: 38)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg36_6"
                     /sec_met_domain="LysR_substrate (E-value: 1.1e-46,
                     bitscore: 150.8, seeds: 361, tool: rule-based-clusters)"
                     /sec_met_domain="HTH_1 (E-value: 4.6e-18, bitscore: 57.0,
                     seeds: 1330, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRVKLKISIFALIDSISLINQRTMTIQQLEYILAVDQFRHFAKA
                     AEYCRVTQPTLSAMIQKLEDELGVKLFDRSMTPVCPTAIGKKVLEQARKILSEVICVKE
                     IISEEQHSLSGTFRLAVLPTIAPYLLPRFFPQLMEKYPDLDIRVMEMKTPDIRKALLTG
                     EADAAIIASMLDDAALTEETLFYEQFLGYVSKKEPLFKHDVIRTSDVTGERLWLLDEGH
                     CFRDQLVRFCQMEAVKISQMAYRLGSMETFMHMVESGKGITFIPELAVMQLSEEQKELV
                     RPFAIPRPTRQIVLVTRKDFIRTSLLQVLKEEIQAAVPKEMLTLQAVQCLV"
     CDS             7473..7946
                     /locus_tag="ctg36_7"
                     /transl_table=11
                     /translation="MKTLNYTHLEEKGANTIVLSLQQLLADFQIHYANLRGFHWNIKGH
                     GFFVLHSKFEDLYNGAAEKVDEIAERILMLGGTPANKYSDYLKMAQIKEVDGVNKADDA
                     LNHILETYGHLIAEERKILSLASSHNDEVTVAMMSDYLKEQEKMVWMLTAYNG"
     CDS             complement(8050..9048)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glyco_hydro_130"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg36_8"
                     /sec_met_domain="Glyco_hydro_130 (E-value: 1.4e-69,
                     bitscore: 226.4, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEEIKIAGAALPAMPWEERPAGCKDVVWRCSANPIIPRDLLPTSN
                     SIFNSAVVPFKDGYAGVFRCDDTNRRMRLHVGFSKDAVHWDINEEPLKFQCDDAEVGTW
                     VYGYDPRVCFIEDRYYVTWCNGYHGPTIGVAYTYDFVTFHQLENAFIPFNRNGVLFPRK
                     INGRFAMLSRPSDNGHTPFGDIFYSESPDMEFWGRHRHVMSPAPFEDSAWQCTKIGAGP
                     IPIETSEGWLLIYHGVLASCNGFVYSFGSALLDIDQPWKVKFRSGPYLISPQKDYECMG
                     DVPNVCFPCAALHDSETGRIAIYYGCADTVTGLAFGYIPEIIEFTKRTSII"
     CDS             complement(9103..10371)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg36_9"
                     /sec_met_domain="MFS_1 (E-value: 3.9e-11, bitscore: 34.4,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKKPISPVCWVPTVYFAMGLPFVALSMVSVLMFSDMEVSNAQIA
                     FWTSLIMLPWTLKPLWSPFLEMFKTKKYFVVATEIITGLAFALVALSLPLPDFFRYAIA
                     LMGIIALSGATHDIAGDGVYLTELTATQQAKYIGWQGAFYNLAKILANGGLVWLAGMLK
                     DEFGVVHAWMIVMLMCAGIMILIGLYHIRILPSGGGASGEVNTMSDALNMLWEVIRSFF
                     QKKHIAFYIVFIILYRFAEGYAIKIVPLFLKASVADGGLGLSTQDIGLVYGTFGAGAFI
                     LGSLLAGYYISAFGLRKTLFSLCCAFNIPFLVYFLLALYQPSDLWIIGMAIVSEYLGYG
                     FGFVGLMLFMMQQVAPGKHQMAHYAFATGIMNLGVMLPGMMSGYLSDWLGYRDFFIWVL
                     IATIPAFIVTWLVPFTYPDGKKK"
     CDS             complement(10621..11634)
                     /locus_tag="ctg36_10"
                     /transl_table=11
                     /translation="MNRHLNFVTLICLITGFVSLASCSNDDDEMDKYQKIYIRTGVAPG
                     AEMGAAVVVDCVSNSSTADRSDFEIQLCAVQPVTRDVTAALGVDTLKVDTYNSANKTKC
                     KLLPQDNYTIETSEVVLKTGQTVADSSFQVVLKNIEKLTNPDGYVLPVTLKGVTGMDEQ
                     AVSTSMKTVYIRIYTSVLYTSYTKPGNWSAVDRSAWSVSCSNVYADDDAKYGAHLAIDG
                     EINTTWFTWGVANAGECWWNTVLDRPVTLTGFSVTKQSAYGSGYNLRSAEIKVRKEGET
                     EWVTYPRVLTFRNFKGADPQYAAIEPPIPNVKEFRINCLTPDNYTGFAEINLYVKQ"
     CDS             complement(11657..12766)
                     /locus_tag="ctg36_11"
                     /transl_table=11
                     /translation="LLACFVLPMILAGCNDADYQVIDNAIYLNEASENGSAKVTVDPEN
                     VTTTTLTVRVGQPVTENVTAVLTVDPSILKEYNEANETSYEVLPEQYFTYDKEIKIAAG
                     DVSAIPSEFRVKPYSNENGELYAIPVSLTEIQGPVSTIGLSSKFIILLDKPLIQSVPFM
                     NTTNAVKPAKDELWGVTTNEWSLEAWVQMDGFDINNQAIFNSGSSDHEVYIRFGDAMIP
                     YNSLQVKTLGSQVNTVTLFEKNKWYHLAFVYNSSGLLSIYINGVLDVTLQTKGGPVRFD
                     KMNMVSSGSYFRNNCQMAQVRLWKSAISQTQIQSNMYFAVKPADPNLIGYWKMDEGKGN
                     AFADCTGHGYDLVAGGTLVWKEHVRFDKQ"
ORIGIN
        1 cgcagtacaa cggttttcaa gaccgccgca atcgaccact ctgccacctc tccagaacta
       61 cggttaagta gtgcttttct cttaaagcgc tgcaaaggta cgaatcattt tttaacttgc
      121 aaattattcc gcaaaaaaat attagaaaag tatatttgga agtaataact gctatctggc
      181 ttctccccat aaataggtat ttttatgcta ttcaacataa aataggaccc ttttatatac
      241 ctaaaccgaa aaaaggttgt aaatttgcgc gctctaaagg ataactaacc actaactgat
      301 taattttatg gaactgaata agacctttaa agatggactt tggagcaaag aaatcaatgt
      361 aagggatttc gttagtaaca acatcactcc ttatgaaggg gatgcttctt tcctgcaagg
      421 acctaccgaa cgcaccaaag ctgtctggaa tcactgtctc aaagctctcg aagaagagag
      481 aaacaataat ggtattcgtg cactcgacta cacaactgta tctactataa cctctcaccc
      541 tgccggctac atcgataaag aaaacgaact gatcgtcgga ctacagaccg atcaggtgtt
      601 aaaacgtgcc atcaaaccgt ttggcggaat caatgtggtt atgaaagctt gccgtgaaaa
      661 cggagtggaa gtagatgaca gagttaagga tatcttcact cactatcgca agactcacaa
      721 tgatggggta ttcgatgtgt ataccgaaga aattcgttcg ttccgttcct tgggattcct
      781 taccggactt cccgacaact atgcacgcgg acgtatcatc ggtgattatc gccgcctggc
      841 tctctatggt cttgaccgtc tgatagaagc taaaaaagaa gatctgcata atctgacagg
      901 tcctatgact gaagcccgca ttcgtcttcg cgaagaagta gccgagcaaa tcaaggccct
      961 gaaagagatt aaagtattgg gcgaatatta tggtttggat ctgagccgac cggcatatac
     1021 cgcacaggaa gctgtacaat gggtgtatat ggcttatctg gctgccgtaa aagagcagga
     1081 tggtgctgcc atgtcactgg gtaatgtatc ttcattcctc gacatctatc ttgaatatga
     1141 attaagccag ggtacgataa ccgaaacatt cgctcaggaa ctgatcgacc aattcgttat
     1201 caaactccgt atggtacgcc acttgcgtat gcagtcgtac aacgatattt ttgcgggtga
     1261 tcccacatgg gtgaccgaat ctatcggtgg acgtttcaat gatggacgta ccaaagttac
     1321 taaaacttct ttccgcttct tgcagacact ttataactta ggcccgtcac cggaacctaa
     1381 catgactgta ctatggagcc ctgagttacc cgaaggtttc aaagcattct gtgcacaagt
     1441 atctatcgac acttcttccg tacaatacga aaacgacgac ctgatgcgtg aagtccgtca
     1501 atcggatgac tacggaatcg cttgttgtgt ttcatatcag gaaatcggaa agcagattca
     1561 gttcttcggt gcacgtgcca accttgccaa agccctgcta ctggctatca acggaggacg
     1621 ttgcgaaaat acaggtacag ttatggtaaa agacatccct gtattgaccg gtgaaacact
     1681 gaagttcgaa gaagtaatgg ccaactataa gaaagtattg atacaaattg cacgtgtata
     1741 caacgaagca atgaatatca tacattacat gcacgataag tattactacg aaaaggcgca
     1801 gatggctttc gtggatactg atccccgcat taacctcgct tatggtgtag ccggactttc
     1861 aatcgccatc gattcactgt ccgccatcaa atatgcacat gtgaaagccc gtcgcaacga
     1921 catcggactg acggagggat tcgatatcga aggtgctttc ccttgtttcg gtaatgacga
     1981 tgaccgtgta gaccacctgg gtgtggacct ggtatatttc tttagcgaag aattaaagaa
     2041 actccccgta tataagaatg cccgtcctac cctttcgctg ctgactatca cttcgaacgt
     2101 aatgtatggc aagaagaccg gtgccactcc tgacggacgc gccaaaggca ttgcctttgc
     2161 tcccggtgcc aaccccatgc acggacgtga taaaaatggt gcaatcgcct cactgagttc
     2221 tgtagccaag ttgcgttatc gcgactcaca ggatggtatc agcaatacat tctcgatcgt
     2281 tcccaaatca ttgggagcaa cacaagaaga ccgtatcgac aatctggtga ccatgatgga
     2341 cggatatttt acaaaaggcg cacaccacct gaacgtaaac gtgctgaacc gggaaatgtt
     2401 gcaggatgcg atggaacatc ccgaaaagta tccgcaactg actatccgtg tctcaggata
     2461 tgccgttaat ttcgtgaaat tgagccgcga acatcagttg gaagtaatca gccgcagttt
     2521 ccacgaaaga atgtaattga atgataaacg tacactcata cgagtcaatg ggaacattcg
     2581 acgggccggg tctccggctc gtcgttttcc ttcaagggtg taacttccgt tgcctctatt
     2641 gtgccaatcc ggacacaatt gaagccaaag gagggacagc aaccgaccct gaggaaatag
     2701 ttcgcatggc cgtcagtcag aaagctttct tcggtaaaaa gggaggtatc accttttccg
     2761 gcggagagcc tacttttcaa gcaaaatcgc ttatcccact ttttaaaaga ctaaaggaag
     2821 caggaatcca tatttgcctt gataccaatg gcgggctatg gaacaatgat gtagaggaac
     2881 tattggaatt gactgatctg gttttattag atatcaaaga atttaatccg gaacatcatc
     2941 agtctttaac cggaagaagc aacgagcaga ccctgaaaac cgcagcctgg cttgaaacca
     3001 atcataaacc attctggttg cgatacgtat tagtgcccgg ctacagtgac ttcgaagacg
     3061 atatccggca gctgggagag catcttggaa cgtaccagat gattcagcgt gtagaaatat
     3121 tgccttacca caccttgggt gttcacaaat atgaagcaat gaacaaagaa tatatgctga
     3181 aaggagtgaa agagaatact ccagagcaga tagaaaaggc tgagaaacta ttcaggcaat
     3241 atttccagac cgtacaagta aattgactta tataagtgtc gaaattcgta ttcaccacag
     3301 attacacgaa tttacacaaa taaagatcat tggcaatcaa tagattaagt tcattctgcg
     3361 gtgaattatg acgactgcac ttatttataa ttttgtaagt cacgatataa aagtctccct
     3421 gttcttgcct taattcatta caatacaagg caagaacagg gagataatgt aaccggcata
     3481 ttttttgcca tcctacttta ataagtgaat cgcaatcctg cctgcaagtt aaagttacaa
     3541 ggcctttctt ttcggatggt ttgtactttg gagccatcat caaagaaata cgaaactccc
     3601 ggttccacat ataggccgac atgatctgtc gcattgaatt gcgctcccac ggcaccggct
     3661 acagaaaatt gcaaaggctt cacattcacc ttatcatccg ccaactttcc ataaacacac
     3721 ttttcaacca ttcctccggc agatacatag agtgtaaaat atttcttttc cagaaaattc
     3781 cagtttccac gtacaggaat acctatataa tgcaatttct gactctgcat cttggtatcc
     3841 ccctgccgtt tgatgtcaga agacaacaac gtataagtca atcccgtctc tacagagaaa
     3901 cctttgggaa gagacttacg tacagacagt ccgaagctaa ccggctgatg atgttcataa
     3961 tccaccacgg cagttgtatt ggacttcagg taagggactc cttcttcaaa tataacttcc
     4021 tgatcggcag gaatactcac agctccattc atgatcgtca tcaagtcgac cctgttagtc
     4081 atcggacggg gcgcaaaatt ttcggaacca tttgtcggaa gtccacctcc attaccgata
     4141 cccactccca tcgaccattt accaccacgt ttagcagaag agtctccgat aggcaactga
     4201 tacttgtctt taccggacgg tcgccgcgct tctttcctct ttggaggctg cgccgtcgca
     4261 ctttcttttt tctcgattgc agcaattgct tcctgttgcg gctcagatct cttttcctcc
     4321 gtcactgcct ccggtcgctt ctctaccagg gaggatacct ccggaacaat caccggatca
     4381 gtattctttg ccaaatagcc cgaaacaggg ttaatactcg tcgttcctac cggcttaact
     4441 ggttcggata cagctacctg tacatccggc aaggcaggtt ccggcaatac atccgggttg
     4501 acagccagtg aaggagccgt tgcataacgg atttcatcag ctaccggact attcagaaaa
     4561 tacaaactga cagcagtcgt taccaccaat accacagctg ccgcagcaac cgcccaccgg
     4621 cgatacggat atattcgttt ttcggttaca ggcatcagtt ccctttccag tcgttcccaa
     4681 ccggaagcag gcatcggctc cgaataatct tcgagcttat ccttgaatgc tttaatccat
     4741 ttttcgtctt ctttcatcat tctatttcat ttttgaaatc caaggttcac ctcagtatct
     4801 gtaaatacat gtcaaccatt ggtcaccaac cattctttca ctttctttgc caatacactt
     4861 tttgcgcgaa aaagctgtga ggcagaagat ttttcattaa tccccaacat ctgtgcgatt
     4921 tccttgtgcg acttatcttc aaaggtgtat aaattgaata cggtacgata tccggcgggg
     4981 agttcattaa taaattgcat cagcactttc tgtggtattg cttcaacagc cgaagcatcc
     5041 ggttcttcat acgtttcggg aacttcatcc agtgccgtgg tctggttcat cacgtcgttc
     5101 tttcttaaga actgtaaaac cgtattcacc attacacgct ccatccatgc tctcagagag
     5161 ccttcacccc gccaggtaaa cttgtcgaag gagtcgaaaa tcttcaggaa accgtcgtgt
     5221 accaagtctt gtgccatgtc cctgtctccg gcataacgaa gacagacacc aagcatgcgc
     5281 cctgcgtact gctcataaag ttctttgcgg gcacgattat ctccctgcct gcaacgttcc
     5341 gacagctcta attcattcat tctcctaaac acgtgtttac cttataaatg cagcaaagat
     5401 agaaatactg cacagagaga acaactcttt tatcactttt gtttctttaa cattttagga
     5461 tgcaatattt catcacttcc tgcattttct caatacaata aagaataaat ctcaatggat
     5521 aaataggata aaaccaacaa gaaacttatg aagaaattta atttaataac ttttgccgtc
     5581 atcctgatgt tattgcccat tttacagtca tgtctggacg atgccaacaa cgacgagtgg
     5641 gtcacttgtc ctccgggtgg aatattggcc atcggcacaa tgaagattcc caatgcggac
     5701 actccaaggg actttttcat tgcattggac aatggagaca atgtacttcc ggcagatacg
     5761 gccgatatac gcaacaggaa atacactgtt gcagaaggtc aaagagtctt cgttggctat
     5821 ctgcagatgg gagaagagaa acctggatat gagaacggta aaatattcac gatagaagat
     5881 atattgacga aagagatcat cccactgacg gaagctacag cagacagcat tggagacgac
     5941 cgtatcaacg tcacagcgca tgcacttacg aaagattatc tgaccatcga atatcaatat
     6001 ctgggcagca tgaatgaaaa taaaaaacac atgctgaact tggtacaaaa cgaaataaca
     6061 ggtcccataa aagatgacgg atatatctat ctggagttcc ggcataatgc ctttaatgac
     6121 tcccccaatc aattgggttc gagccttgtt tctttcaagc tggatagtat agccgagcaa
     6181 ttggcgacag ccaaaggaat aaaactccgt gtgaacacca tttatgacaa tatacagtat
     6241 gtcacaatag atatcaacga agacaaaaac ttaaaaataa aatcatttca ttctcaataa
     6301 aacaacaaga aacacctaca caatcaggca aaacgagtaa taattctgat acataaaaga
     6361 aataaggcgg cgatgtttgt gaaaatatcg ccgtcgtttt tatattatac cagacactga
     6421 acggcctgca gggtaagcat ctccttggga accgccgcct gaatctcctc tttcaaaacc
     6481 tgcagcagac tggtgcggat gaagtctttc cgggtcacca ggacaatctg acgggtaggc
     6541 cgcgggatag caaacggacg gaccagttct ttctgctctt cgctcaattg catcactgcc
     6601 agttcgggaa taaacgtaat ccccttacca ctctctacca tatgcataaa ggtttccata
     6661 ctacccagcc gatacgccat ttggctgatc ttaaccgctt ccatctgaca aaaacgaacc
     6721 aactgatcgc ggaagcaatg cccttcgtca agaagccaaa gccgttcccc tgtcacatcg
     6781 gacgtacgaa tcacatcgtg cttgaacaac ggttccttct ttgagacata gcccaggaat
     6841 tgctcgtaga ataaggtctc ttccgttaat gcggcatcat ccagcatgct ggcaatgata
     6901 gcagcatccg cttcaccggt cagcagagcc ttgcgaatgt cgggcgtctt catctccatc
     6961 acccgtatat caagatccgg gtatttctcc atcagttgcg gaaagaaacg gggcagaaga
     7021 taaggtgcaa tcgtcggtaa cactgccaat cggaatgtac ccgacaggga gtgctgttct
     7081 tcgctgatga tctccttgac acagataact tccgaaagaa tcttacgggc ctgttccagc
     7141 actttcttac caatggcagt agggcaaacc ggtgtcatgc tacggtcgaa cagtttcacc
     7201 cccaattcgt cttccagctt ttggatcatt gcactcaaag taggttgcgt cacccggcaa
     7261 tactcggcag ctttagcaaa atgccggaac tggtccacag ccagaatata ttccaattgt
     7321 tgtatagtca tcgttctctg atttattaaa gatatagaat ctatcaatgc aaagatagaa
     7381 attttcagtt tgacacgaat cattttgtgc cgtatctttg ttccagataa aaagaagaaa
     7441 tatagtatta actcaaaaaa aacaatatca ttatgaagac tttaaattat acacatttgg
     7501 aagaaaaagg agctaacacc atcgtactgt cattacagca actgcttgcc gattttcaga
     7561 ttcattatgc aaacctgaga ggatttcact ggaacatcaa aggacacggt ttcttcgtac
     7621 tgcacagcaa gtttgaagat ttatataatg gagccgccga aaaggtggac gaaatagccg
     7681 aacgtatact gatgctggga ggaactcccg ccaataaata cagtgactat ctgaagatgg
     7741 cgcagatcaa ggaagtggac ggagtgaata aggccgacga cgctctgaat catattctcg
     7801 aaacttacgg gcatctgatt gcggaagaac gtaaaatcct gtctctcgcc tcttcacaca
     7861 acgacgaagt aacagtggcc atgatgagcg actacctgaa agaacaggaa aagatggttt
     7921 ggatgctgac tgcatacaac ggataacagc cgaaagggtg tagccatctg accgaaaagg
     7981 tgtagccata caagcaaaag ggtgtagcca tcccggcggg atagctacac cctttctgtt
     8041 ttattcgatt cagatgatac ttgtacgttt ggtaaattca ataatctccg gaatgtatcc
     8101 gaatgcgagc ccggtcactg tatccgcaca cccataatag atggcaatcc gtccggtctc
     8161 cgaatcatga agcgccgcgc atgggaaaca gacattaggc acatcaccca tacattcgta
     8221 atccttctga ggtgaaatca gataaggccc cgaacggaat tttactttcc agggttgatc
     8281 gatgtcaagc agtgccgaac caaaactata cacaaaaccg ttgcaggaag ccaatacacc
     8341 atgatagatc agcaaccagc cttccgaggt ttcaatcggg ataggccctg caccgatctt
     8401 ggtacactgc caggcactgt cttcgaacgg agccggcgac ataacatgac gatgacgtcc
     8461 ccaaaactcc atatcgggag actcgctata gaaaatatct ccaaaaggag tatgcccatt
     8521 atcactcggg cggctcaaca tcgcaaaacg accgtttatc ttacgaggga acaagactcc
     8581 attccgattg aaaggaataa aggcattctc caactggtga aaagtaacaa aatcataggt
     8641 gtaggccaca ccgatagtag gaccatgata gccattacac caggtcacat agtagcggtc
     8701 ttcgataaag caaacccgtg ggtcatatcc atagacccag gttccaacct cagcatcatc
     8761 acattgaaac tttaacggtt cttcgttgat atcccaatga acagcatcct tgctgaatcc
     8821 cacatgcaaa cgcatgcgac gattagtatc atcacaacgg aacacccctg catagccatc
     8881 cttaaacgga actacggcac tgttgaatat actgtttgaa gtagggagca agtcgcgcgg
     8941 aataatcgga ttggccgaac aacgccacac tacatcttta catcctgccg gacgttcttc
     9001 ccaaggcata gccggcaaag cagcacctgc aattttaatt tcttccatga ttcgattaaa
     9061 ttaatattat gtatatatct tgtttatatt gaaaatctct ttttatttct tctttccgtc
     9121 cggatatgtg aaaggtacca gccaagtcac gataaaagcc ggtatggtag cgataagtac
     9181 ccagataaag aaatcgcgat aacccagcca atcgctcagg tatccgctca tcattccggg
     9241 aagcatcacc cccagattca taataccggt agcaaaagca taatgtgcca tctgatgttt
     9301 gccgggagcc acttgctgca tcataaagag catcaatccg acaaaaccaa acccgtaacc
     9361 caagtattca gacacaatgg ccataccaat aatccataga tcggaaggct ggtaaagggc
     9421 taacaggaaa tataccaaga acggaatatt aaaagcgcaa cataaagaaa acaaagtctt
     9481 ccgaagtccg aaagccgaaa tgtaataacc ggccaaaagc gaaccgagaa taaaagctcc
     9541 cgctccgaac gtaccatata ccagtccgat atcctgagtg ctgagtccca atccaccatc
     9601 cgcaaccgac gctttcagga acaacggtac aatcttgatg gcatatcctt cggcaaaccg
     9661 gtacaaaatg ataaagacaa tgtagaaagc aatatgtttt ttttggaaaa aagagcggat
     9721 gacttcccaa agcatattca atgcgtcact catcgtattc acttcaccgg aagcgcctcc
     9781 tcccgaaggc aaaatccgga tgtggtaaag accgatcaga atcataatac ccgcacacat
     9841 caacatgaca atcatccagg catgtaccac tccaaattca tccttcagca tacctgccag
     9901 ccaaaccaag cctccgttgg caagtatctt ggccagatta taaaaagctc cctgccaacc
     9961 gatatacttg gcttgctggg tagcagtcag ttcagtcagg tatactccgt cacccgcaat
    10021 gtcatgagtc gcaccactga gagcaatgat ccccatcaga gcgatggcat aacgaaaaaa
    10081 gtcgggcagc ggcagcgaaa gtgctaccaa tgcaaatgcc agtccggtaa tgatttccgt
    10141 agcgacaaca aagtatttct tcgttttaaa catttccaga aacggactcc ataaaggctt
    10201 caatgtccag ggaagcataa tgagagaagt ccagaaagca atctgtgcat tcgacacttc
    10261 catatcggaa aacataagga cagaaaccat cgaaagggcc acaaacggca atcccatagc
    10321 aaagtaaaca gtaggcaccc aacatacagg gcttatcggc tttttattca tcagttagtt
    10381 ttttataata attccatcgg ttaacaattc cagtaagcaa agatagggga tattaaaaac
    10441 ataacccaag attacgacaa gaagttgctt tcattattta ataatacaac tcacccggga
    10501 aaactactaa cctctatcac ccttttttta ttaaacttta tcaatacaat acacgcaaag
    10561 aagcaccgaa gactttcatc cccgatgcct ctcgccccct tatctacaat ctaaacacct
    10621 ctattgcttc acatataaat ttatctcagc aaacccggta taattatccg gagtcagaca
    10681 gtttattctg aattccttta cattcgggat aggtggttcg atggccgcat attgcggatc
    10741 agccccttta aaatttctga aagtcaagac tctcgggtaa gtaacccact cggtttcacc
    10801 ctctttccga accttaatct cagcacttct cagattataa cccgatccgt aggcactctg
    10861 tttagtgacc gaaaatccgg ttaaggtaac aggccggtcc agtaccgtat tccaccaaca
    10921 ctctccggca ttagccactc cccatgtaaa ccaagtagta tttatctcac cgtcaatagc
    10981 cagatgtgca ccatatttgg catcatcatc ggcataaaca ttgctgcaac ttacactcca
    11041 cgcacttcga tctacagcgg accaattccc gggtttcgta taactggtat aaagcacgct
    11101 ggtataaatc cggatataaa ccgtcttcat agatgtactg acagcctgtt cgtccatgcc
    11161 cgtaactcct ttaagcgtca cgggaagcac atatccgtca ggattagtca acttttctat
    11221 attcttcaaa acgacctgaa aagatgaatc ggccactgtc tgtcccgttt ttaagacaac
    11281 ttcacttgtt tcaatagtat aattatcttg gggcaacaac ttacatttcg tcttattggc
    11341 agaattgtaa gtatccactt tcagcgtatc tactcccaaa gcggcagtga catcccgcgt
    11401 aaccggctgt acggcacaca attgtatttc aaaatcagaa cggtcggcag tagaggaatt
    11461 gctcacacaa tccaccacta ccgcagcacc catttcggcc cccggtgcaa ctcccgttct
    11521 gatatatatc ttttgatatt tgtccatttc atcatcatcg ttgctgcacg aagccaacga
    11581 tacaaagcct gttatcaggc agattaaggt cacaaaattc aaatgtctat tcatatctta
    11641 tcttcttttt acatagttat tgcttatcaa aacgaacatg ctctttccag acaagagttc
    11701 ctcctgccac caaatcgtat ccgtgtccgg tacagtcggc aaaggcattt cctttacctt
    11761 catccatttt ccaatagcct atcaggttcg gatcggcggg tttcacggca aaatacatgt
    11821 tggactgaat ttgcgtctgg ctgattgcgc tcttccaaag acgcacctgg gccatctgac
    11881 aattgttgcg gaagtagcta ccgctcgaaa ccatgttcat cttgtcgaat cttaccgggc
    11941 caccctttgt ctgcagagtc acgtcgagca ctccgttgat ataaatcgac aataacccgg
    12001 aagaattata aacgaaggcc agatgatacc acttattctt ctcaaacaaa gtcaccgtat
    12061 tgacctgact tccaagtgtc ttcacctgta atgaattata agggatcata gcgtcaccga
    12121 aacggatata aacctcgtgg tcgctgctgc ccgaattaaa tatagcctga ttattaatat
    12181 cgaatccgtc catctgtacc caagcctcga gtgaccattc attggttgtc actccccaca
    12241 attcgtcctt ggcgggcttc acggcattgg tcgtattcat aaacggtaca gactgtatca
    12301 gcggcttatc cagcaaaatg ataaacttcg acgaaagccc gattgtggac accggtccct
    12361 gaatttctgt gagagatacc ggaatagcat acaattctcc gttttcgttt gaataaggtt
    12421 tcactctaaa ctcactgggg attgcgctaa catcgcctgc cgctatcttt atctctttgt
    12481 cataagtaaa atactgctcg ggaaggactt cgtacgaagt ttcattagct tcattgtact
    12541 ctttaagaat agaaggatct accgtcagga cagcagtcac attttcggtt acaggctgtc
    12601 ccacacgtac ggtcagagta gttgttgtta cattttcagg atcaacggta acctttgccg
    12661 aaccattctc ggatgcttca ttcaaataaa tcgcattgtc gataacctgg taatcggcat
    12721 cgttgcatcc tgccaggatc atcggcagaa cgaaacaggc aagcaaacat tgttttattg
    12781 ttattctttt cataatcaaa ttctttaaag tcattttaca gcaggattca ttattctgat
    12841 tgcttcacgc aggtacttat attcgatgtc gcccggatag tcatattcca tgtgataggt
    12901 gcctactcca cccttccgta cctgttttcc gtcaatagtc ggagtccagc gtgccatgcc
    12961 ggcaagtgct ctcattttgt ttccgtaacg atctacataa tcacctcctc ctgtcggagc
    13021 ataagattcg aaattctccg taacgatgta catattagcc actttctccg gaggaagtat
    13081 tcctttaaag ttggcaatcg taccagccag acgtctgtca agattagcgt cggaattacc
    13141 cgcaaggtta gagtatgcct gcacaatgaa atagtcaaag taaggcccgg tttccggatg
    13201 aatactttga ggctcgccat caatcacaag taaccgtccc gtacccgatt taggtccgat
    13261 tctttc
//
