LOCUS       c00674_gnlPro..        14771 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|DOOGDFOH_1026.
ACCESSION   c00674_gnlPro..
VERSION     c00674_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 22:26:50
            Original ID  :: gnl|Prokka|DOOGDFOH_1026
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 4484
            Orig. end    :: 19255
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14771
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[14484:19227]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..14743
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..14771
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14771
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(651..1994)
                     /locus_tag="ctg674_6"
                     /transl_table=11
                     /translation="MKKEYLIYKLSEAMKDCTRIDNELFPKFDVKRGLRNEDGTGVLVG
                     LTKIGNVVGYERIPGGGLKPIPGKLFYRGYDLEDLAHAILKEKRFGFEEVAYLLLSGSL
                     PDKEELASFRELINDNMPLEQKTKMNIIELEGNNIMNILARSVLEMYRFDPNPDDTSRD
                     NLMRQSIDLISKFPTIIAYAFNMLRHATFGRSLHIRHPQENLSIAENFLYMLKRDYTEL
                     DARTLDLLLVLQAEHGGGNNSTFTVRVTSSTGTDTYSAIAAGIGSLKGPLHGGANIQVA
                     DMFHHLQENIQDWTNVDEIDTYFTRMLNKEVYNKTGLIYGIGHAVYTISDPRAVLLKEL
                     ARDLAHEKGREREFAFLELLEERAIATFGKIKNNGKTVSSNVDFYSGFVYEMIGLPQEI
                     YTPLFAMARIVGWCAHRNEELNFEGKRIIRPAYKNVLEEEQYVPLKKR"
     CDS             complement(2007..3197)
                     /locus_tag="ctg674_7"
                     /transl_table=11
                     /translation="MSKITKQQNGVLSVPDVPTIPFITGDGVGAEITPAMQAIVDAAVD
                     MSYGGARRIEWKEVLAGERAFRATGSWLPDETMEVFKEYLIGIKGPLTTPVGGGIRSLN
                     VALRQTLDLYVCLRPVRWFRGVVSPVKEPEKVNMYIFRENTEDIYAGIEWEAGTPEAKK
                     FYRFLHEEMGVSKVRFPETSSFGVKPVSREGTERLVRAACRYALQHELPSVTLVHKGNI
                     MKFTEGGFKKWGYELAEREFADALASGKLVIKDCIADAFLQNTLLIPEEYSVIATLNLN
                     GDYISDQLAAMVGGIGIAPGANINYDSGHAIFEATHGTAPNIAGKNVVNPCSLILSAVM
                     MLEYIGWQEPADLIVEALEASFAEGKATNDLARFMHKGQPLSTSEFTREIINRIKN"
     CDS             complement(3360..5603)
                     /locus_tag="ctg674_8"
                     /transl_table=11
                     /translation="MVYDLNMLKSFYASYKGKMEHVRAALKRPLTLAEKILYTHLYNVA
                     DLKNYERGEDYVNFRPDRVAMQDATAQMALLQFMNAGKEAVAVPSTVHCDHLIQAYRGA
                     ERDIETATQTNREVYDFLRDVSSRYGIGFWKPGAGIIHQVVLENYAFPGGMMVGTDSHT
                     PNAGGLGMVAIGVGGADAVDVMTGMEWELKMPKLIGVRLTGELNGWTAPKDVILKLAGI
                     LTVKGGTNAIIEYFGPGTASLSATGKATICNMGAEVGATTSLFPYDERMAVYLKATGRE
                     EVAAMADSVAADLRADDEVMARPGDFYDRVIEINLSELEPYINGPFTPDAATPISEFAE
                     KVVTNGYPRKMEVGLIGSCTNSSYQDISRAASVARQVNEKNLGVAAPLIVNPGSEQIRA
                     TAERDGMMDVFEKMGATIMANACGPCIGQWKRHTDDPTRKNSIVTSFNRNFAKRADGNP
                     NTFAFVASPEIVLALTIAGDLCFNPLKDRLVNHDGEKVKLSEPQGDELPSAGFVAGNQG
                     YQAPGGEKNEIRVAPDSQRLQLLTPFPAWDGNDFLNMPLLIKAQGKCTTDHISMAGPWL
                     RFRGHLENISDNMLMGAVNAFNGETNKVWNRLTNTYETVSGTAKQYKADGISSIVVAEE
                     NYGEGSSREHAAMEPRFLHVKVILAKSFARIHETNLKKQGMLAVTFADKADYDRIREHD
                     LISVVGLKEFSPGRNLEVILHHEDGTEERFVVQHTYNEQQIGWFRAGSALNAK"
     CDS             5862..7766
                     /locus_tag="ctg674_9"
                     /transl_table=11
                     /translation="MNDNKIKSSSPLSDLQHQQLLLRMEYEYEKEEFRRQTETMGIARK
                     VKRGLCWYPVGTGRSFYNSLNQLVIEIERKEDKDIEHVFEFGRPVCFFEQGYDGKIHYF
                     NSICTVSYADEERMVVAVPGAGSLLEIQGAERLGVQLYFDETSYRTMFEALEDVIRAKG
                     NRLAELRDILLSKQPSCWRETYPVRFPWLNSTQEAAVNKVLCAKDVAIVHGPPGTGKTT
                     TLVEAIYETLHRENQVLVCAQSNTAVDWIAEKLVDRGVPVLRIGNPSRVNDKMLSFTYE
                     RRFEGHPAYTELWGIRKSIREMGNRMRKSSYSEREAARSRINHLRERATELEIQINEDL
                     FSGARVIASTLVSSNHRILTGRRFTTLFIDEAAQALEAACWIAIRKADRVIFAGDHCQL
                     PPTIKCIEAGRNGLEQTLMEKVAANKQETVSLLKVQYRMHQSIMQFSSEWFYQGELQAA
                     PEVTNRGILDLDLPMSWIDTSEMEFHEEFIGESFGRINKPEANLLLQELEAYIRKIGEK
                     RVLEERIDFGLISPYKAQVQYLRGKLKGCSFFRPFRSQITIHTVDGFQGQERDVIFISL
                     VRANEDGQIGFLNDLRRMNVAITRARMKLVILGDAVTMSKHAFYKKLIGYIRHISQGL"
     CDS             complement(7879..9798)
                     /locus_tag="ctg674_10"
                     /transl_table=11
                     /translation="MKNRIYTMKGMLATLLGAFLLGYAVTGCIDEKDHYKPDDKTSGVP
                     NSFDFATTQDVQLDLKYDVPVKDYQVLFELYFENPLTTDAEGQVVKRTDITPKVTRMTD
                     GTGKYRAKETVPAYGEEVYIYTSYIGVPMLYKTKIVGNTITADINWDTAAEESVQTRAE
                     GEYQTVPQGFYTLGSWNVKGRPNYLDSEGVIELTSSFYQTINQTIPEGGNCPRKYRQSA
                     DIVINDELGAEVKVRFVGGTSAAYSAFGYYCYPEGAAKKQIENARKYVVFPNTKTGVGI
                     KGGECVKLHYIDENGEDQGTTFPKGTKIGWFISNDAFTKKGEKTGSVGKGLGMFYSTTA
                     LNSDGRTHTAAFKINDFIVLSFEDWTDQDYNDVMFNIWSNPIEAIAPDVPSVDPIDPDD
                     ASVAYRMTYKGILAFEDNWPSKGDYDLNDVIVKYSSILEFNTKNQVLSAEDTFTAMWSG
                     ALFKNGFAYQLNTDRSNVECSILDGKSGWDKQGLDKDLEQATISVFANAIEETGENTKT
                     STFKIQNKFKQPVDHETFGVAPYNPFIFLHQNTDKNRTEVHLVNHGPTSKENMNLFNTQ
                     QDLSDKDKGIYYVSDQNYPFAIHLSDVESFSTTEKEAIDKSYPRFASWAQSGGTTDKDW
                     YLKK"
     CDS             complement(10001..11044)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg674_11"
                     /sec_met_domain="IlvN (E-value: 1.2e-45, bitscore: 145.0,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 1.2e-40, bitscore: 129.1,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLNFGGVTENVVTREEFPLEKAREVLKNETIAVIGYGVQGPGQ
                     SLNLRDNGFNVIVGQRPGKTYEKAVADGWVPGETLFGIEEACEKGTIIMCLLSDAAVMS
                     VWPTIKPYLTAGKALYFSHGFAITWSDRTGVVPQKDIDVIMVAPKGSGTSLRTMFLEGR
                     GLNSSYAIYQDATGRAMERTIALGIGVGSGYLFETTFVREATSDLTGERGSLMGAIQGL
                     LLAQYEVLRENGHTPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMG
                     PFHDAIKPVVQKLYNSVKTGNEAQISIDSNSKPDYREKLEAELKALRESEMWQTAVTVR
                     KLRPENN"
     CDS             complement(11126..11710)
                     /locus_tag="ctg674_12"
                     /transl_table=11
                     /translation="MKKIVFLLLLCVACCMNAQEFHLIPKVGLNLANTTGEVDSKVRPG
                     LNIGLGGDVMLTERFGIETGVYYSMQGSKYKGGGVSYTDKLDYINVPVYAKEFIYKGLY
                     VFGGPQFSFNVNSENKSSSDYGTTVIGMNVIRKFDCGVGLGAGYQFERGLLISLNYNIG
                     LINVNKSWASDSNPKANNSVVQLNVGWRFAL"
     CDS             complement(11728..12471)
                     /locus_tag="ctg674_13"
                     /transl_table=11
                     /translation="MSNNKKIGSYKFIAEPFHVDFNGRLTMGVLGNHLLNCAGFHASER
                     GFGIATLNEDNYTWVLSRLAIDLEEMPYQYEEFTVQTWVENVYRLFTDRNFAIIDKDGK
                     KIGYARSVWAMINLNTRKPADLLTLHGGSIVDYVCDEPCPIEKPSRIKVATDQPCAKLT
                     AKYSDIDINGHVNSIRYIEHILDLFPIDLYKSKRIQRFEMAYVAESYYGDELSFFEEEV
                     SENEYHVEIKKNGSEVVCRAKVKFV"
     CDS             complement(12472..13032)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg674_14"
                     /sec_met_domain="ALS_ss_C (E-value: 5e-19, bitscore: 58.4,
                     seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKTLYTLIVHSENFAGLLNQVTAVFTRRQINIESLNVSASSIKG
                     VHKYTITAWTDKDTIEKVVKQIEKKIDVLQAHYFTEDEIYFHEIALYKVSMPEFQSQPE
                     ASKVIRRYNARIVEVNPVFAIVEKNGISEEITSLYEELSALNCVLQFVRSGRVAITTSC
                     FERVNEFLADRETKYNLSKKEEK"
     CDS             complement(13046..14743)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg674_15"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.2e-47, bitscore:
                     151.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKDIISGGEALMRSLEYHGVKTIFGYPGGSIMPVFDALYDHRET
                     LNHILVRHEQGAAHAAQGFARASGEVGVCLVTSGPGATNTITGIADAMIDSTPIVVIAG
                     QVGTAFLGTDAFQEVDLVGITQPITKWSYQIRRAEDVPWAVARAFYIAKSGRPGPVVLD
                     FAKNAQVEKAEYMPAKLDFIRSYVPVPETDPEAVKAAAELINGAERPLVLVGQGVELGN
                     AQQELRAFIEKADMPAGCTLLGLSALPTEHPLNKGMLGMHGNLGPNMNTNKCDVLIAVG
                     MRFDDRVTGNLATYAKQAKVIHFDIDPAEINKNVHADVAVLGNCKETLSAVTALLQPNE
                     HKEWLDSFLPYEQVEEEKVIRPELHPMGDTLSMGEVVRAVSDATNHEAILVTDVGQNQM
                     MSARYFKYSKDRSMITSGGLGTMGFGLPAAIGATFGRPDRTVCVFMGDGGLQMNIQELG
                     TIMEQKAPVKIIVLNNNFLGNVRQWQAMFFNRKYSFTPMLNPDYIKIASAYDIPAKRVF
                     TREELADAIDEMIATDGPFLLEACVIEEGNVLPMTPPGGSVNQMLLEC"
ORIGIN
        1 tatccaaaag caaggagtca gcaaccatcc gggtgtataa tagtccgagg gagcaagata
       61 gaatatccat tctccctgca tcagtccgtt gagaatatta aagatcactc ccatcaaaag
      121 aatgagtacc ggcatcttgc tctttccttt catcaggaaa ggaaaaacaa aagccctttg
      181 gaagtaatgt agttggaaaa aaagaaagaa agtgagttcg acaggtaaaa aacgtcggtc
      241 ggaatgccac cacaaccatc ccataaccag aaaaacagga gcttccatca gaatccaggc
      301 tatcttatta ttcaccgaga ttccccagga acggctgcga aacatgccat atcccgccct
      361 gacaaaataa agggctatga atacgaccaa agccatcagg cccattacta aaagaagcag
      421 attaaagctt tctatactca tatccaagat tttatacaag gacaaagtta aaagaaaaac
      481 tttaaaggga caaatagttt acgaaaataa agcaagcgta tcacaaaagt ctgttctacc
      541 acagattggc agacggtaca aacatagaac tgacagataa tcaatcaatg ccggtgccgg
      601 tctgtgcaat ctgtaaatct gtggtgaact tctgacttca agcttctctt ttaccgtttc
      661 tttaacggta catattgttc ttcttccaac acatttttat aagccggacg aatgatacgt
      721 ttaccttcaa aattcaactc ttcgttgcga tgggcacacc aacccacgat acgcgccatg
      781 gcaaacaagg gggtatagat ttcctgcggc aggccaatca tctcataaac aaaaccggaa
      841 taaaaatcaa cgttgctgga tactgttttc ccattattct taatcttacc gaaagtagcg
      901 atagcacgtt cttccaaaag ttcaagaaaa gcaaactccc gttcacgacc tttctcgtgt
      961 gccaagtcac gtgcaagttc cttcagcaac acagctcgcg gatcggaaat ggtatatacg
     1021 gcatgcccga tgccatatat caatccggtc ttattgtaaa cctccttatt caacatacgg
     1081 gtaaagtaag tatcgatttc gtctacattg gtccagtcct gaatattttc ctgtaaatga
     1141 tggaacatat cggctacctg aatattggct cctccgtgaa gcgggccttt cagcgacccg
     1201 atgcctgcgg caatggccga gtatgtatct gtaccggtag acgaagttac ccggacagta
     1261 aacgtagagt tgttacctcc tccgtgctct gcctgaagca ccaacaaaag gtcgagtgta
     1321 cgcgcatcca gctcggtata atcgcgtttc agcatataga gaaagttttc ggcaatcgac
     1381 agattctcct gcggatgacg aatgtgtaac gaacgcccga aggtggcatg acgcaacatg
     1441 ttaaaagcat aagcaataat ggtcgggaat ttcgagatca gatcgatgct ctgacgcatc
     1501 aggttgtcac gtgaagtatc atccggatta ggatcgaaac gatacatctc gagtacgctg
     1561 cgcgccagaa tattcataat attgtttcct tcaagttcga tgatattcat cttggtcttc
     1621 tgctccaaag gcatattatc attgatcagc tcgcgaaacg aagccagttc ttccttatcg
     1681 ggcaaactgc cggataacag caggtaggcc acctcttcaa atccgaaacg tttttctttt
     1741 aaaatggcgt gggctaaatc ttctaggtca tatccacggt aaaataactt tcccgggatc
     1801 ggcttcagac cacctccggg gattcgttcg tatcctacga cattaccaat cttagtcaat
     1861 ccgaccaata cacctgtacc gtcttcattg cgaagccccc gtttaacgtc aaattttgga
     1921 aacaattcgt tatcaatccg ggtacaatcc ttcattgcct cggagagttt ataaatcaaa
     1981 tattcttttt tcatgtcctg aaggtattaa tttttaattc ggttaatgat ttcccgggta
     2041 aattccgaag tagagagcgg ctggcctttg tgcatgaaac gtgccaggtc attagtggct
     2101 ttcccctcgg caaaactggc ttcaagcgcc tcgacgataa gatcggcggg ttcttgccag
     2161 cctatatatt caagcatcat aacggccgaa agtatcagtg aacagggatt caccacattc
     2221 tttccggcaa tattgggggc tgtcccatga gtggcctcaa agatggcgtg tccggaatca
     2281 taattgatat tggctcccgg tgcaatacca atgccaccta ccatcgcagc cagttggtcg
     2341 gaaatatagt ctccgttcag attcagagtg gcaatgaccg aatattcttc aggaatcaaa
     2401 agagtgttct gcaaaaaggc atcggctata cagtctttga tcaccagttt acctgaggca
     2461 agagcatctg caaactcccg ctcagccaat tcgtaccccc acttcttaaa acctccttct
     2521 gtgaatttca tgatattacc tttgtgcacc aaggtgaccg agggcaattc atgctgcaac
     2581 gcataacggc aggcagcgcg taccagacgc tccgtcccct cacgcgaaac cggtttcaca
     2641 ccaaaagaag aggtttcggg gaaacgtact ttactgactc ccatctcttc gtgcaagaac
     2701 cggtagaact tcttagcttc cggagtgcct gcttcccatt cgataccggc atagatatct
     2761 tccgtattct cacgaaagat gtacatattc accttttcgg gctctttgac cggagacacc
     2821 actccgcgga accaacgtac cggacgcagg cagacatata aatcgagtgt ctggcgcaaa
     2881 gccacgttca acgaacgtat tcctcctcct accggagtag tcaacggtcc tttgatgcct
     2941 atcagatact ccttgaaaac ctccatcgtt tcgtccggca accacgaacc ggtagcccgg
     3001 aaagcacgtt caccggccag tacttctttc cattcgatac gccgggcacc accatacgac
     3061 atgtctaccg ccgcatctac tatcgcctgc atggccggag ttatttccgc tcctactcca
     3121 tcacccgtta taaaaggtat tgtcggtaca tccggcactg acaatactcc attttgctgt
     3181 ttggtaattt tactcatcta tttatctttt tatatactcc tccaatcgtg ttccgaagta
     3241 aaggttcgtt ggtttagaac caacactcct taccttttaa actaaagacc cgttggtttt
     3301 aaacctaagt cctattgatt ttcaaaccta aaagcgggcc cctgaaagcc tcctgaaggc
     3361 tattttgcat tcaaagcaga accggcacgg aaccagccga tctgttgttc attgtaagta
     3421 tgttgtacta cgaaccgttc ttccgtacca tcttcgtggt gcaatatcac ctccagattg
     3481 cgtccgggtg aaaactcttt cagtccgact accgagatca aatcgtgctc acgaatccgg
     3541 tcataatcag ccttgtctgc aaatgtaaca gccagcatac cttgcttttt cagattagtc
     3601 tcatggatac gggcaaaact cttagccagg atcaccttta catgaaggaa acgcggttcc
     3661 atagcggcat gctcacgact ggaaccttca ccgtaatttt cttcggccac aacgatggaa
     3721 gagataccgt ccgccttata ctgtttagcc gtacccgaaa cagtttcata ggtattggtc
     3781 aaacgattcc ataccttatt cgtttcgcca ttgaaagcat tcaccgctcc catcagcata
     3841 ttatcagata tattctccag atgcccccgg aaccgaagcc agggacccgc catcgaaata
     3901 tggtctgtcg tacacttacc ctgtgctttg ataagcaacg gcatattgag aaaatcattg
     3961 ccatcccacg cggggaaagg agtcaacaac tgcaaccgtt gagaatcggg agccactctg
     4021 atctcgtttt tctcaccgcc gggagcctga tacccctgat taccggctac aaatccggct
     4081 gatggaagtt cgtcaccttg aggttcactg agtttcacct tttcaccgtc atgattcacc
     4141 aaacggtctt tcagcggatt gaaacaaaga tctccggcaa tagtcaatgc caaaacaatt
     4201 tcaggagaag ccacaaaagc aaaagtattc ggattaccgt cggcacgttt ggcaaaatta
     4261 cggttaaagg aagtcactat cgagttttta cgggtcggat cgtccgtatg gcgtttccac
     4321 tgtccgatac agggaccaca ggcattagcc ataatcgtag ctcccatctt ttcgaacaca
     4381 tccatcatgc cgtcacgctc ggccgtagca cgaatctgtt cggatcccgg attcacaatc
     4441 agcggtgccg ccactcccag attcttttca ttcacctgcc gggcaacaga ggcggcacgg
     4501 ctgatatcct gataagaaga gttggtacaa gatcctatca accccacttc catcttccgg
     4561 ggataaccgt ttgttaccac tttctctgca aactctgaaa taggagtagc agcgtccgga
     4621 gtaaacggac cattaatata aggttccagt tcggaaaggt ttatctcaat aacccgatca
     4681 taaaaatcgc ccggtcgtgc catcacttcg tcatctgcac gcaagtcggc agctacactg
     4741 tcagccatcg cagctacttc ttcacgtccg gttgctttca gataaacagc catccgttca
     4801 tcatacggga atagtgaagt ggttgccccc acttcggcac ccatattgca gatggtggcc
     4861 tttcctgtag ccgatagcga agctgtaccc gggccaaaat attcgataat ggcattcgtt
     4921 ccacccttca cggtcaagat gcccgccagt ttcagtatca cgtctttcgg agctgtccat
     4981 ccgttcaact cgcctgtcaa acggactcca atcagttttg gcatcttaag ctcccactcc
     5041 atacctgtca ttacatccac agcatcggct ccgcctacac cgatagctac cattccgaga
     5101 cctcctgcat tgggagtatg tgagtctgta ccgaccatca tcccacccgg aaaagcataa
     5161 ttttcaagta ctacctggtg aatgataccc gctcccggtt tccagaaacc gatgccataa
     5221 cgggaagaga catcacgcag aaaatcgtac acctcccgat tggtttgtgt agcagtttca
     5281 atatcgcgtt cagccccccg ataagcttgt atcaggtggt cgcaatgaac cgtggaaggt
     5341 actgccaccg cttctttacc cgcattcata aattgcaaca gagccatctg agcagtagca
     5401 tcctgcatag caacgcggtc cgggcgaaag ttgacatagt cttcacccct ttcataattt
     5461 tttaaatccg ccacattata caaatgtgta tacaaaatct tttcagccaa cgtcaaagga
     5521 cgtttcaagg ctgcacgaac atgctccatc ttccctttat aggaagcata gaagctcttc
     5581 aacatattca aatcatatac cataacaatt tcggttttat ctgttcttct atttattata
     5641 accaataata tgaaagaaag gtttaacaaa ttgaaatgtt tattccaacc cggaaacaga
     5701 attgttatct ttgcgggaaa ttttgtgaga agctataagt atagctgcta caaatcagat
     5761 gctacaagct acaaatgact gtgacaggtt ctgcataaat ttcgtaattt gtagtcattc
     5821 cataactata gttcttagca tataacttac agccaatcaa gatgaatgat aataaaataa
     5881 agtcttcttc tccactcagt gatcttcagc atcagcaact tttgctacgc atggaatatg
     5941 aatacgagaa agaagaattc cgccggcaga cagagacgat gggcattgca cggaaagtaa
     6001 aacgagggct ctgctggtat ccggtcggga cgggacggag tttctacaat tcactgaacc
     6061 aattggtcat cgaaatagaa aggaaagaag ataaagacat cgaacatgta ttcgaattcg
     6121 gacgtccggt ttgctttttc gaacagggat atgacggaaa aatacattat ttcaattcca
     6181 tctgtacagt cagttatgcc gacgaggaac gtatggtagt agctgtaccc ggtgccggat
     6241 ctctacttga aatacaagga gcagaacgtc tgggagtaca actctatttt gatgaaacct
     6301 cctatcgtac catgttcgaa gcgctggaag atgtgattcg cgccaaaggc aaccgccttg
     6361 ccgaactacg tgatatattg ctaagcaagc aaccctcctg ctggagggaa acctatccgg
     6421 tccgtttccc ttggttgaac agcactcagg aagcagcagt caacaaagta ctttgcgcca
     6481 aagacgtagc catcgttcac ggtcctccgg ggaccggaaa gaccaccact cttgtagaag
     6541 ccatctacga gaccctgcac cgcgaaaatc aagtcctagt ctgtgcacaa agcaacacgg
     6601 ccgtcgactg gattgccgag aagctggtgg accgcggagt gcctgtattg cgtatcggca
     6661 atccgagccg ggtaaatgac aagatgcttt catttactta cgaacgccgt ttcgaggggc
     6721 atccggccta taccgaactc tggggaatac gtaaatcgat ccgggaaatg ggaaaccgga
     6781 tgcgcaaaag cagttactcg gaacgggaag ctgcacgcag ccgcatcaat catctgaggg
     6841 agcgtgccac ggaactggaa atacaaatca atgaagatct gttttcgggg gcacgggtca
     6901 ttgcttccac attggtcagc agtaaccacc gtatcctgac cggccggcga tttaccacac
     6961 tctttatcga cgaggcagca caagcccttg aggctgcctg ttggatagcc atccgaaaag
     7021 cagaccgcgt catctttgcc ggagaccatt gtcagttgcc tcccacaata aaatgcatag
     7081 aagcgggccg gaacgggttg gaacaaacat taatggaaaa agtagcagcc aacaagcagg
     7141 aaacggtctc actcctgaaa gttcagtacc gcatgcatca gtctattatg caattctcct
     7201 ccgaatggtt ctaccaaggc gaactacaag ccgcccccga agtgaccaac cgggggatac
     7261 tcgatctgga cctgcccatg agttggattg acacctccga aatggagttc cacgaagaat
     7321 ttataggaga aagcttcggc cgcatcaata aaccggaagc aaacttattg ttgcaagaac
     7381 ttgaagcata catccgcaaa atcggcgaga agcgtgtatt ggaagagcgt atagacttcg
     7441 gccttatctc cccttacaaa gcgcaggtac agtatctgag aggaaaactc aaaggctgtt
     7501 cattcttccg ccccttccgt agccagatca ccatccatac agtagatggt tttcagggac
     7561 aggagcgtga tgtcattttc atcagcctcg tccgcgctaa cgaagatgga caaatcggtt
     7621 ttctcaacga cttgcgccga atgaacgtag ccatcacccg cgcccgaatg aaactggtta
     7681 tattaggaga tgcggtcaca atgagcaagc atgctttcta taagaaattg atcggatata
     7741 tccggcacat cagccaagga ctctgatgcc gatctcctta tttcagtcgt aacttctgtt
     7801 tccatttaaa accataaaat aaggggctgt cggattttcg gacagcccct tgttctatag
     7861 cataaaaacg acatcaactt atttcttcaa ataccaatcc ttatctgtcg ttccgccgga
     7921 ttgtgcccat gaagcaaaac gaggatacga cttatcaata gcttccttct ccgttgtact
     7981 gaatgactcg acatccgaca gatgaatggc aaacggataa ttctgatcgg acacataata
     8041 aatgccttta tctttatctg acaaatcctg ctgggtattg aacagattca tattttcttt
     8101 agaggttggt ccgtgattta ccaaatgcac ctccgtacgg ttcttgtccg tattctgatg
     8161 caagaagata aaaggattgt agggtgccac tccgaaagtt tcatgatcga ctggctgttt
     8221 aaatttgttc tgaatcttaa aagtagaagt cttagtgttc tctcccgtct cttcaatcgc
     8281 attggcaaac accgaaatgg tggcctgctc caagtctttg tctaatcctt gtttgtccca
     8341 tcccgacttt ccatccaata tgctgcattc cacattgctt ctatcggtat tcaactgata
     8401 ggcaaagcca ttcttaaaga gagctccgga ccacattgcc gtaaacgtat cttcagcgga
     8461 aagcacctga ttcttggtat tgaactctaa tatagagcta tatttcacaa ttacatcgtt
     8521 caaatcgtaa tcacccttag aaggccaatt gtcttcaaaa gccaaaatac ctttataagt
     8581 catgcgataa gcaaccgacg catcatccgg atctatcgga tctaccgaag gtacatccgg
     8641 agcaatagct tcaatcggat tagaccagat gttaaacatc acatcattgt aatcctgatc
     8701 agtccaatct tcaaatgata aaactataaa atcattgatc ttgaatgcag ccgtatgggt
     8761 acgaccatcc gaattcaagg cagtggtcga ataaaacatt ccgagtcctt taccaacact
     8821 gccggtcttt tcaccctttt tcgtaaatgc atcattactg ataaaccaac ctatctttgt
     8881 tccttttgga aaagtagtcc cttggtcttc accattttca tcgatataat gcagcttcac
     8941 acactctccg ccttttatgc cgactccggt tttcgtattg ggaaagacca catatttcct
     9001 agcattctct atctgttttt tagccgctcc ttccggataa caataatatc cgaaagcact
     9061 gtacgcagca cttgtacctc caacaaaacg caccttcact tcagctccca attcatcgtt
     9121 gataacaatg tcagccgatt gccgatattt ccgaggacaa tttccacctt ccggaattgt
     9181 ttgattaatc gtctgataaa atgaagaagt caattctatt accccttcac tatccagata
     9241 attagggcgt cccttcacgt tccaacttcc taaagtataa aatccctgag gcactgtctg
     9301 atactcgcct tcggcacgtg tctgaacaga ctcctctgcc gccgtatccc aatttatatc
     9361 ggctgtaatc gtattcccta ctattttagt cttatacaac atcggcactc cgatataaga
     9421 agtatagata taaacctcct ccccataggc cggtaccgtc tccttggcac gatattttcc
     9481 ggttccatca gtcattctcg taaccttggg agtgatatca gtacgtttca ccacctgccc
     9541 ttcggcatct gtcgtcaacg gattttcaaa atagagttca aacaaaacct gataatcttt
     9601 cacaggaaca tcatacttta gatccaattg gacatcctga gtagtcgcaa aatcaaaaga
     9661 gttaggcact cctgatgttt tatcgtccgg tttataatga tctttttcat caatacaacc
     9721 tgttactgca taccctagta aaaaagcacc cagtaatgta gccagcatcc ctttcattgt
     9781 ataaatacga tttttcatat gatataatat tgtttgttgt ttgatcaggg cacaaagata
     9841 tatattaaac ttgatttatc tatccaaaca atctatctat ttttcatatt ctacaacata
     9901 ccattctaac aactcagaca caaaacacta attacaagta aaataaaagg aagaaacagt
     9961 agtttcctcc ttttatcata agttgtataa tctattcaga tcaattattc tccggacgaa
    10021 gtttacgaac ggttacagct gtctgccaca tttcgctttc acgcaatgcc ttcagttcgg
    10081 cctccagttt ctcgcgataa tccggttttg aattagagtc gatagagatc tgtgcctcgt
    10141 taccggtctt tacactatta tataatttct gaacaacggg tttaatagca tcgtggaacg
    10201 ggcccatcca gtcaagagca ccacgctgag ccgtagtcga gcagttggca tacatccagt
    10261 ccataccatt cttagcaaac agcggcatca atgactgagt taactcctca accgtttcgt
    10321 taaatgcctc agatggagta tgaccgttct cacgcaaaac ctcatactga gccaacagca
    10381 aaccttgtat agctcccatc agcgaaccac gttcacctgt caggtcggaa gtagcttcac
    10441 ggacaaaagt cgtttcaaac agatatccgg aacctacgcc gatacccaat gcgatggttc
    10501 tctccatagc tctgccggta gcatcctgat agatggcata cgaagagttc agtccgcgac
    10561 cttcaaggaa catcgtacgg agtgaagtac ccgaaccctt cggagcgacc ataatgacat
    10621 cgatatcttt ctgtggaaca acaccggtgc gatcgctcca tgtaattgcg aaaccgtgag
    10681 agaaatagag tgctttcccg gcagtcaggt aaggtttgat agtaggccat acagacatta
    10741 cggctgcatc tgacaacaga cacataataa tagtaccttt ctcgcatgcc tcttcgatgc
    10801 cgaacagtgt ttcacccgga acccagccgt ctgccactgc tttttcatat gtttttcccg
    10861 gacgctgacc aacgattaca ttgaagccat tatcgcgcag gttcagtgat tgacccggtc
    10921 cctgcacacc gtaaccgata acagcgattg tttcattctt caatacctca cgagcttttt
    10981 ccaaaggaaa ttcttcacgg gttactacat tttccgtaac accgccaaaa ttcaattgtg
    11041 ccatttttct ttttgtttta aaagtcttgt tccgttcgga cgaaaacaaa accgattatt
    11101 aataattaaa cttatattct ttatcttaca gtgcaaaacg ccaaccgaca tttagctgga
    11161 ccacactatt gtttgcttta ggattagagt cgcttgccca agatttgttt acgttaatca
    11221 gtccgatgtt atagtttaga gagatcagca gaccacgttc aaactgataa ccggctccaa
    11281 gccccactcc acaatcaaac ttgcgaatca cattcatgcc tatgactgtg gtaccatagt
    11341 cggaggatga tttgttctct gagttcacat tgaaactgaa ctgcggccct ccaaacacat
    11401 acagcccctt atatataaac tctttcgcat ataccggaac attgatataa tccagtttat
    11461 ccgtataaga gactccgccc cctttatatt tgcttccctg catggagtaa tacactcctg
    11521 tttctattcc aaaccgttcg gtcagcatga catcacctcc cagaccgata ttgagtccgg
    11581 gacgcacttt agaatccacc tctccggtag tatttgccag attcaaaccg accttcggaa
    11641 tcagatgaaa ctcctgtgca ttcatgcagc aagcaacaca gagcagcaaa agaaaaacaa
    11701 tcttcttcat tttaatcaca ttttaaacta cacaaacttc acttttgccc ggcatacaac
    11761 ttcactgccg tttttcttaa tctcgacgtg atattcattc tcacttactt cctcttcaaa
    11821 aaaagaaagc tcgtcgccat aataactttc tgccacatag gccatttcaa atcgctgaat
    11881 ccgtttcgat ttatacaaat cgatcggaaa caaatcgagg atatgttcta tataacgaat
    11941 gctgttcaca tgaccattga tgtcgatatc gctgtattta gctgtcaact tagcacaagg
    12001 ttggtcagta gccactttga tacgcgaagg cttttcgatc ggacaaggtt cgtcacatac
    12061 atagtccaca atactaccgc catgcaacgt cagcaaatca gccggcttgc gggtatttaa
    12121 attaatcatg gcccataccg aacgggcata tccgatcttc ttgccgtcct tgtctataat
    12181 ggcaaaatta cgatcagtaa aaagacgata tacattctcc acccatgtct gtacagtaaa
    12241 ctcttcatat tgataaggca tctcttccag atcgatggcc agacgagaca atacccatgt
    12301 ataattgtcc tcattcaatg tagcgattcc aaagccgcgt tcactggcat gaaagccggc
    12361 acagttcaac agatggttgc caagcacccc cattgtcaaa cgtccgttga agtctacatg
    12421 aaaaggctcc gcaataaact tataactccc tatcttctta ttgttactca ttcacttttc
    12481 ctctttcttg cttaagttat atttggtctc acgatctgcc agaaactcgt tcacacgttc
    12541 aaagcaactg gtagtgattg ccacacgtcc cgaacgcaca aattgcaaca cacaattcaa
    12601 tgcactcaac tcttcgtaga gagaagtaat ttcttcactg attccatttt tctcgacgat
    12661 ggcaaatacc ggattcactt ccacaatccg tgcattatag cgacgaatca ccttcgaagc
    12721 ttccggctgt gactgaaatt cgggcataga caccttataa agagctattt catgaaaata
    12781 gatttcatct tcagtgaaat aatgtgcctg aagcacatcg atcttcttct caatctgttt
    12841 gacaaccttc tctatcgtat ctttatcggt ccaagccgta atagtatatt tatgcacccc
    12901 cttgatagat gaagccgaaa cattcaggct ttctatatta atctgccgac gggtaaatac
    12961 tgccgtaacc tgattcaaca atccggcaaa gttctctgaa tgaacaatta atgtatataa
    13021 tgtcttatcc ataattccta acttattagc attccaacaa catctggtta actgaacctc
    13081 ccggaggggt catcggcaac acatttccct cttcaatcac acaagcttcc aacaggaacg
    13141 gaccgtctgt cgcaatcatc tcgtcaatcg catcagccag ttcttcacgg gtaaagactc
    13201 ttttggccgg tatatcataa gcagaagcaa tcttaatata atcgggattc agcatgggtg
    13261 tgaacgagta tttacggttg aagaacattg cctgccattg gcgtacattg cccaggaaat
    13321 tattgtttaa tacgataatt ttaaccggtg ccttctgttc cataatggtt cccaactcct
    13381 gaatgttcat ttgcagacca ccgtcaccca taaatacaca aaccgtacgg tccggtcggc
    13441 caaaggttgc accgatagca gccggcaacc cgaatcccat ggtaccaagt cctccggaag
    13501 taatcatact ccggtctttt gaatatttaa agtatcgggc agacatcatc tggttttgac
    13561 cgacatcggt caccaatatc gcttcatgat tggtcgcatc gcttaccgca cgcaccactt
    13621 cccccatcga aagcgtatct cccatcggat gcaattccgg acggattacc ttttcttctt
    13681 ccacctgttc ataaggcagg aaactatcca gccattcttt atgctcgttg ggctgcagca
    13741 atgccgtaac agcagagagc gtctctttac agttacccag aaccgctaca tctgcatgta
    13801 cattcttatt aatttcagcc ggatcgatat caaaatgaat cactttcgcc tgcttggcgt
    13861 acgtagccag gtttccggtc acacggtcgt caaaacgcat gccgacagca atcaggacat
    13921 cacatttatt ggtgttcata ttcggtccga gattaccgtg cattcccagc atacctttgt
    13981 tcaaaggatg ctcggttggc aaagccgaca gtcccaacaa cgtacatccg gcgggcatat
    14041 ctgccttttc gatgaaagca cgcaattcct gttgtgcgtt gcccagttcc acaccttgcc
    14101 ccaccaatac caacgggcgc tctgcaccgt taattaattc ggcagccgct ttcacggcct
    14161 ccgggtcagt ctcgggtaca ggcacgtaac tgcgtatgaa atcgagtttc gcaggcatat
    14221 attcggcttt ctctacctgg gcattttttg caaagtcgag cactaccggt cccgggcgtc
    14281 cgcttttcgc tatataaaag gcgcgggcca ccgcccatgg cacatcttcg gcacgacgga
    14341 tctgataact ccattttgta attggctgcg tgatgcctac caagtcgacc tcctgaaaag
    14401 catctgtccc caaaaaagct gttcccacct gtccggcaat gactacaatc ggtgtactgt
    14461 cgatcattgc atctgcaata ccggttatgg tattggtagc accggggccg ctcgtcacca
    14521 ggcaaactcc gacctcaccc gaagcacggg caaatccctg agccgcatgt gccgcccctt
    14581 gttcgtggcg aaccaaaata tgattcaaag tctctctatg atcgtataag gcatcgaata
    14641 cgggcatgat agatcctccg ggataaccaa agatcgtctt tacaccatga tattccaaag
    14701 aacgcattaa tgcttcaccg cctgaaatta tatctttact catgtactaa aatttacgat
    14761 tttacgattt a
//
