Select genomic region:
Overview
1.1
2.1
3.1
5.1
5.2
7.1
8.1
9.1
14.1
14.2
16.1
16.2

### Identified secondary metabolite regions using strictness 'relaxed'

gnlProkkaMDFAHGHL_1 (original name was: gnl|Prokka|MDFAHGHL_1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | lanthipeptide-class-ii | 104,242 | 127,283 | loseolamycin A1/loseolamycin A2 | Polyketide | 8%

gnlProkkaMDFAHGHL_2 (original name was: gnl|Prokka|MDFAHGHL_2)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 2.1 | NRPS,transAT-PKS,betalactone | 81,859 | 219,690 | fengycin | NRP | 93%

gnlProkkaMDFAHGHL_3 (original name was: gnl|Prokka|MDFAHGHL_3)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 3.1 | terpene | 8,210 | 30,093 |

gnlProkkaMDFAHGHL_5 (original name was: gnl|Prokka|MDFAHGHL_5)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 5.1 | T3PKS | 895 | 42,139 |
Region 5.2 | transAT-PKS | 159,479 | 263,800 | difficidin | Polyketide | 100%

gnlProkkaMDFAHGHL_7 (original name was: gnl|Prokka|MDFAHGHL_7)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 7.1 | NRP-metallophore,NRPS,RiPP-like | 65,773 | 117,560 | bacillibactin | NRP | 100%

gnlProkkaMDFAHGHL_8 (original name was: gnl|Prokka|MDFAHGHL_8)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 8.1 | other | 502,321 | 543,739 | bacilysin | Other | 100%

gnlProkkaMDFAHGHL_9 (original name was: gnl|Prokka|MDFAHGHL_9)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 9.1 | NRPS | 11,832 | 77,240 | surfactin | NRP:Lipopeptide | 91%

gnlProkkaMDFAHGHL_14 (original name was: gnl|Prokka|MDFAHGHL_14)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 14.1 | PKS-like | 175,458 | 216,702 | butirosin A/butirosin B | Saccharide | 7%
Region 14.2 | terpene | 299,485 | 320,225 |

gnlProkkaMDFAHGHL_16 (original name was: gnl|Prokka|MDFAHGHL_16)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 16.1 | transAT-PKS | 133,835 | 222,063 | macrolactin H | Polyketide | 100%
Region 16.2 | transAT-PKS,T3PKS,NRPS,NRPS-like | 443,342 | 536,922 | bacillaene | Polyketide+NRP | 100%

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | lanthipeptide-class-ii | 104,242 | 127,283 | loseolamycin A1/loseolamycin A2 | Polyketide | 8%
Region 2.1 | NRPS,transAT-PKS,betalactone | 81,859 | 219,690 | fengycin | NRP | 93%
Region 3.1 | terpene | 8,210 | 30,093 |
Region 5.1 | T3PKS | 895 | 42,139 |
Region 5.2 | transAT-PKS | 159,479 | 263,800 | difficidin | Polyketide | 100%
Region 7.1 | NRP-metallophore,NRPS,RiPP-like | 65,773 | 117,560 | bacillibactin | NRP | 100%
Region 8.1 | other | 502,321 | 543,739 | bacilysin | Other | 100%
Region 9.1 | NRPS | 11,832 | 77,240 | surfactin | NRP:Lipopeptide | 91%
Region 14.1 | PKS-like | 175,458 | 216,702 | butirosin A/butirosin B | Saccharide | 7%
Region 14.2 | terpene | 299,485 | 320,225 |
Region 16.1 | transAT-PKS | 133,835 | 222,063 | macrolactin H | Polyketide | 100%
Region 16.2 | transAT-PKS,T3PKS,NRPS,NRPS-like | 443,342 | 536,922 | bacillaene | Polyketide+NRP | 100%

No secondary metabolite regions were found in these records:
  gnlProkkaMDFAHGHL_4 (original name was: gnl|Prokka|MDFAHGHL_4)
  gnlProkkaMDFAHGHL_6 (original name was: gnl|Prokka|MDFAHGHL_6)
  gnlProkkaMDFAHGHL_10 (original name was: gnl|Prokka|MDFAHGHL_10)
  gnlProkkaMDFAHGHL_11 (original name was: gnl|Prokka|MDFAHGHL_11)
  gnlProkkaMDFAHGHL_12 (original name was: gnl|Prokka|MDFAHGHL_12)
  gnlProkkaMDFAHGHL_13 (original name was: gnl|Prokka|MDFAHGHL_13)
  gnlProkkaMDFAHGHL_15 (original name was: gnl|Prokka|MDFAHGHL_15)

Compact view
gnlProkkaMDFAHGHL_1 - Region 1 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 104,242 - 127,283 nt. (total: 23,042 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

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Gene overview
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Lanthipeptides
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
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Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

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Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for ctg1_109

ctg1_108
Leader:
MSEKQIERTIRAWKDPEFRKTLSDVADHPSGSIEARQLSMLGS
Core:
E E N V N P M T T P V S P A P T V V I R V S L K V C P T F K I K C K V
Core with dehydrations:
E E N V N P M Dhb Dhb P V Dha P A P Dhb V V I R V Dha L K V Cys P Dhb F K I K Cys K V

#### MIBiG 3.1 matches for ctg1_108

14.3% BGC0000553 (SSGG_RS09925): Lanthipeptide: SRO15-2212
20
R V S L K V C
26
+V S L V C
4
Q V S L L V C
10

#### antiSMASH-DB 4.0 matches for ctg1_108

100.0% NZ_CP039297.1 and 2 others:
NZ_CP040378.1 Lanthipeptides: D1120_RS00435_lanthipeptide NZ_CP059318.1 Lanthipeptides: HZT45_RS00565_lanthipeptide
Lanthipeptides: E4T61_RS00570_lanthipeptide
1
E E N V N P M T T P V S P A P T V V I R V S L K V C P T F K I K C K V
35
E E N V N P M T T P V S P A P T V V I R V S L K V C P T F K I K C K V
1
E E N V N P M T T P V S P A P T V V I R V S L K V C P T F K I K C K V
35
97.1% NZ_CP040672.1 and 1 other:
NZ_CP087137.1 Lanthipeptides: LOK79_RS00585_lanthipeptide
Lanthipeptides: FGE23_RS05605_lanthipeptide
1
E E N V N P M T T P V S P A P T V V I R V S L K V C P T F K I K C K V
35
E+N V N P M T T P V S P A P T V V I R V S L K V C P T F K I K C K V
1
E D N V N P M T T P V S P A P T V V I R V S L K V C P T F K I K C K V
35
42.9% NC_018499.1 and 5 others:
NC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27845_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptide
Lanthipeptides: BCK_RS27845_lanthipeptide
3
N V N P M T T P V S P A P T V V I R V S L K V C P T F K I K C K
34
+V N P T T P +P ++ V S L +C P T K K
2
D V N P E T T P A T P---T I V A V S L G I C P T T K C T S K
30
with 43 more sequence matches
42.9% NZ_CP023481.1 and 2 others:
NZ_JALARN010000006.1 Lanthipeptides: MOE03_RS17410_lanthipeptide NZ_JAQCPU010000013.1 Lanthipeptides: PG077_RS20425_lanthipeptide
Lanthipeptides: COP00_RS24795_lanthipeptide
5
N P M T T P V S P A P T V V I R V---S L K V C P T F K I K C
33
N T P S V +R V S+K C P+F K K C
1
N D E I T P Q S T V V C V S L R V C K W S I K Y C P S F K R K C
32
42.9% NZ_PIJH01000018.1: Lanthipeptides: CV632_RS18055_lanthipeptide
9
T P V S P A P T V V---I R V---S L K V C P T F K I K C
33
T V S P T+V +R+ S L+ C P+F K+K C
2
T E V S P Q S T I V C V S L R I C N W S L R F C P S F K V K C
32
40.0% NC_009328.1: Lanthipeptides: GTNG_RS18990_lanthipeptide
9
T P V S P A P T V V---I R V---S L K V C P T F K I K C
33
T V S P T+V +R+ S L+ C P+F K++C
2
T E V S P Q S T I V C V S L R I C N W S L R F C P S F K V R C
32
40.0% NZ_CP013862.1 and 1 other:
NZ_CP013862.1 Lanthipeptides: AOX59_RS09365_lanthipeptide
Lanthipeptides: AOX59_RS09365_lanthipeptide
3
N V N P M T T P V S P A P T V V I R V S L K V C P T F K
30
+V+P T T P S A I V S C P T K
2
D V D P Q T T P S S V A--C G I A V S A L F C P T T K
27
40.0% NZ_CP015591.1 and 15 others:
NZ_CP078085.1 Lanthipeptides: KU891_RS29355_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29350_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29345_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29340_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29335_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29930_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29925_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29920_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29910_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29930_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29925_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29920_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29910_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23050_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23050_lanthipeptide
Lanthipeptides: A7A70_RS27550_lanthipeptide
3
N V N P M T T P V S P A P T V V---I R V S L K V C P T F K
30
+V N P T T P + P T+V I ++ +C P T K
2
D V N P E T T P A T--P T I V E A T I A A T V S I C P T T K
30
40.0% NZ_CP036019.1 and 1 other:
NZ_CP036019.1 Lanthipeptides: EXW52_RS27205_lanthipeptide
Lanthipeptides: EXW52_RS27205_lanthipeptide
3
N V N P M T T P V S P A P T V V I R V S L K V C P T F K I K C K
34
+V+P T T P +P T+V+ +S+ +C P T K K
2
D V S P E T T P A T P--T I V V A I S V G L C P T T K C T S K
31
40.0% NZ_JALAJI010000006.1 and 3 others:
NZ_JALAOO010000008.1 Lanthipeptides: MOC69_RS16910_lanthipeptide NZ_JALAXE010000008.1 Lanthipeptides: MOF11_RS14910_lanthipeptide NZ_JALAXI010000013.1 Lanthipeptides: MOE73_RS14185_lanthipeptide
Lanthipeptides: MOB90_RS08905_lanthipeptide
5
N P M T T P V S P A P T V V I R V---S L K V C P T F K I K C
33
N T P S V +R+ S+K C P+F K K C
1
N D E I T P Q S T V V C V S L R L C K W S I K Y C P S F K K K C
32
40.0% NZ_JALANL010000003.1 and 3 others:
NZ_MUEI01000003.1 Lanthipeptides: BV582_RS23575_lanthipeptide NZ_NIJN01000002.1 Lanthipeptides: CHCC5027_RS22460_lanthipeptide NZ_NIMF01000037.1 Lanthipeptides: CHCC14814_RS22115_lanthipeptide
Lanthipeptides: MOC63_RS03255_lanthipeptide
5
N P M T T P V S P A P T V V I R V---S L K V C P T F K I K C
33
N T P S V +R+ S+K C P+F K K C
1
N D E I T P Q S T V V C V S L R I C K W S I K Y C P S F K R K C
32
40.0% NZ_NUML01000015.1: Lanthipeptides: COD66_RS20140_lanthipeptide
3
N V N P M T T P V S P A P T V V I R V S L K V C P T F K I K C K
34
+V+P T T P +P T+V+ +S+ +C P T K K
2
D V S P E T T P A T P--T I V V G I S V G L C P T T K C T S K
31
38.5% NZ_CP009280.1 and 1 other:
NZ_CP009280.1 Lanthipeptides: P40081_RS37160_lanthipeptide
Lanthipeptides: P40081_RS37160_lanthipeptide
3
N V N P M T T P V--S P A P T V V--I R V S L K V C P T F K I K C K
34
+V N P T T P+ S P V+ + +S +C P T K K
3
D V N P E T T P L T T S S W P C V I G A V D I S A N L C P T T K C T S K
38
37.1% NZ_CM000721.1 and 9 others:
NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptide NZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide
Lanthipeptides: BCERE0010_RS29355_lanthipeptide
3
N V N P M T T P V S P A-P T V V I R V S L K V C P T F K
30
+V N P T T P +P I V+ +C P T K
2
D V N P E T T P A T P T I I G A T I A V T A S L C P T T K
30
37.1% NZ_CP036019.1 and 7 others:
NZ_CP036019.1 Lanthipeptides: EXW52_RS27180_lanthipeptide NZ_CP036019.1 Lanthipeptides: EXW52_RS27175_lanthipeptide NZ_CP036019.1 Lanthipeptides: EXW52_RS27170_lanthipeptide NZ_CP036019.1 Lanthipeptides: EXW52_RS27190_lanthipeptide NZ_CP036019.1 Lanthipeptides: EXW52_RS27180_lanthipeptide NZ_CP036019.1 Lanthipeptides: EXW52_RS27175_lanthipeptide NZ_CP036019.1 Lanthipeptides: EXW52_RS27170_lanthipeptide
Lanthipeptides: EXW52_RS27190_lanthipeptide
3
N V N P M T T P V S P A P T V V I R V S L K V C P T F K I K C K
34
+V+P T T P +P T+V+ +S+ +C P T + K
2
D V S P E T T P A T P--T I V V A I S V G L C P T N R C T S K
31
37.1% NZ_FOHE01000009.1: Lanthipeptides: BMX40_RS20255_lanthipeptide
2
E N V N P M T T P V S P A P T V V I R V S L K V C P T F K I K C
33
E V P +T V + + + S+K C P+F K K C
2
E E V T P Q S T V V C V S L R L C-K W S I K Y C P S F K R K C
32
37.1% NZ_MLKL01000042.1: Lanthipeptides: BKK45_RS27405_lanthipeptide
3
N V N P M T T P V S P A P T V V I R V S L K V C P T
28
+V N P T T P +P ++ V S+K+C P T
2
D V N P E T T P A T P---T I V A V S V K L C P T
24
34.3% NZ_CACZYW010000004.1 and 3 others:
NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02820_lanthipeptide NZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide NZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide
Lanthipeptides: HUF10_RS02820_lanthipeptide
8
T T P V S P A P T V V I R V S L----K V C P T
28
T T P +P A V++ V S K C P T
1
T T P A T P A T P V I V A V S A Y V S D K T C P T
25
34.3% NZ_CP036019.1 and 1 other:
NZ_CP036019.1 Lanthipeptides: EXW52_RS27195_lanthipeptide
Lanthipeptides: EXW52_RS27195_lanthipeptide
3
N V N P M T T P V S P A P T V V I R V S L K V C P T
28
+V+P T T P +P T+V+ +S+ +C P T
2
D V S P E T T P A T P--T I V V A I S V G L C P T
25
34.3% NZ_JAMDLZ010000027.1: Lanthipeptides: M5W82_RS15520_lanthipeptide
2
E N V N P M T T P V S P A P T V V I R V S L K V C P T F K
30
+ P T P+ T V I +S L C P T K
1
S E I Q P K W T P L----T V T I P I S L A G C P T T K
25
34.3% NZ_JAQQWR010000009.1: Lanthipeptides: PQ473_RS20190_lanthipeptide
2
E N V N P M T T P V S P A P T V--V I R V S L K V C
26
+V N P T T P+ A +V I S+K C
1
S D V N P E T T P L C V A Y S V G A T I V F S V K H C
27
34.2% NC_006322.1 and 7 others:
NC_006322.1 Lanthipeptides: BLI_RS20290_lanthipeptide NZ_CP033218.1 Lanthipeptides: D9Y32_RS07810_lanthipeptide NZ_CP033218.1 Lanthipeptides: D9Y32_RS07810_lanthipeptide NZ_LQYL01000021.1 Lanthipeptides: B4090_RS08830_lanthipeptide NZ_LQYL01000021.1 Lanthipeptides: B4090_RS08830_lanthipeptide NZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11870_lanthipeptide NZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11870_lanthipeptide
Lanthipeptides: BLI_RS20290_lanthipeptide
2
E N V N P M T T P V S P A P----T V V I R V S L K V C P T F K
30
+V N P T T P + + T + V S +C P T K
1
N D V N P E T T P A T T S S W T C I T A G V T V S A S L C P T T K
33
31.4% NZ_JAHHYI010000012.1: Lanthipeptides: KM925_RS25405_lanthipeptide
3
N V N P M T T P--V S P A P T V V I R V S L K V C
26
+V P T T P V T V I +S +C
2
D V Q P E T T P A C V G A G I T V G I A I S K L L C
27
30.8% NZ_CP009288.1 and 3 others:
NZ_CP009288.1 Lanthipeptides: PDUR_RS29295_lanthipeptide NZ_CP076607.1 Lanthipeptides: KP014_RS01575_lanthipeptide NZ_CP076607.1 Lanthipeptides: KP014_RS01575_lanthipeptide
Lanthipeptides: PDUR_RS29295_lanthipeptide
3
N V N P M T T P V S P A P----T V V I R V S L K V C P T F K
30
+V N P T T ++ + T + V S +C P T K
3
D V N P E T T I L T T S S W T C I T A G V T V S A S L C P T T K
34
28.6% NZ_WIXN01000006.1 and 1 other:
NZ_WIXN01000006.1 Lanthipeptides: GHD25_RS06900_lanthipeptide
Lanthipeptides: GHD25_RS06900_lanthipeptide
15
P T V V I R V S L K V C P T
28
P T +I V S L V C P T
9
P T T I I P V S L A V C P T
22
25.7% NZ_BOSN01000007.1 and 5 others:
NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18000_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide NZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptide NZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptide
Lanthipeptides: KJS43_RS18000_lanthipeptide
15
P T V V I R V S L K V C P T F K
30
P +I V S L +C P T K
8
P A T I I P V S L A I C P T T K
23
25.7% NZ_CP028922.1: Lanthipeptides: allorf_4058819_4059013_lanthipeptide
7
M T T P V S P A P T V V I R V S L K V C P T F K I K C K V
35
+ T P S + K C P T+ K C +
7
I C T P G S C D G D R C W L T T F K G C P T Y G P K C D I
35
25.7% NZ_CP067069.1 and 13 others:
NZ_CP085413.1 Lanthipeptides: LIS80_RS25350_lanthipeptide NZ_JH792105.1 Lanthipeptides: II5_RS26960_lanthipeptide NZ_JH792240.1 Lanthipeptides: IIK_RS26240_lanthipeptide NZ_MOOT01000061.1 Lanthipeptides: BK765_RS23985_lanthipeptide NZ_NTUF01000024.1 Lanthipeptides: CN379_RS26680_lanthipeptide NZ_NVCZ01000001.1 Lanthipeptides: COK75_RS01180_lanthipeptide NZ_NVDK01000008.1 Lanthipeptides: COK95_RS05665_lanthipeptide NZ_NVEA01000001.1 Lanthipeptides: COL15_RS00010_lanthipeptide NZ_PIYQ01000022.1 Lanthipeptides: CW365_RS08190_lanthipeptide NZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20675_lanthipeptide NZ_WBPC01000027.1 Lanthipeptides: F8159_RS19560_lanthipeptide NZ_WBPE01000025.1 Lanthipeptides: F8161_RS14435_lanthipeptide NZ_WBPK01000016.1 Lanthipeptides: F8167_RS15685_lanthipeptide
Lanthipeptides: JCR32_RS24620_lanthipeptide
2
E N V N P M T T P V S P A P T V V I R V S L K V C
26
+V P T T P+ + I S+K+C
1
S D V Q P E T T P L C V G V I I G I T A S I K I C
25
25.7% NZ_JACSMH010000008.1 and 2 others:
NZ_JACSMX010000006.1 Lanthipeptides: KNQ03_RS15615_lanthipeptide NZ_JACSMZ010000005.1 Lanthipeptides: KNQ06_RS16025_lanthipeptide
Lanthipeptides: KNP89_RS14470_lanthipeptide
3
N V N P M T T P V S P A P T V V I R V S L K V C
26
+V P T T P V + +S L C
2
D V Q P E T T P F C V G V I V G V T I S L S K C
25
25.7% NZ_JACYTN010000030.1: Lanthipeptides: allorf_08178_08354_lanthipeptide
7
M T T P V S P A P T V V I R V S L K V C P T F K I K C K V
35
+ T P S + + K C P T+ K C +
7
I C T P G S C S G D S C W L T T F K G C P T Y G P K C D I
35
25.7% NZ_LDKE01000067.1: Lanthipeptides: ABB04_RS19960_lanthipeptide
2
E N V N P M T T P V S P A P T V V I R V S L K V C
26
+V P T T P+ + I S+K+C
1
S D V K P E T T P L C V G V I I G I T A S I K I C
25
25.7% NZ_NIST01000001.1: Lanthipeptides: CD001_RS09870_lanthipeptide
5
N P M T T P V S P A P T V V I R V S L K V C P T
28
+ T P T+ R V S L C T
2
G G I C T P S C L T G T L N C R V S L T F C R T
25
23.8% NZ_CP010976.1: Lanthipeptides: UB51_RS20985_lanthipeptide
3
N V N P M T T P V S P A P T V V I
19
+V N P T T P + P T+V I
2
D V N P E T T P A T--P T I V I
16
22.9% NZ_CP016020.1 and 34 others:
NZ_CP067069.1 Lanthipeptides: JCR32_RS24625_lanthipeptide NZ_CP085413.1 Lanthipeptides: LIS80_RS25380_lanthipeptide NZ_CP085413.1 Lanthipeptides: LIS80_RS25375_lanthipeptide NZ_CP085413.1 Lanthipeptides: LIS80_RS25370_lanthipeptide NZ_CP085413.1 Lanthipeptides: LIS80_RS25365_lanthipeptide NZ_CP085413.1 Lanthipeptides: LIS80_RS25360_lanthipeptide NZ_CP085413.1 Lanthipeptides: LIS80_RS25355_lanthipeptide NZ_JH792105.1 Lanthipeptides: II5_RS26955_lanthipeptide NZ_LDKE01000067.1 Lanthipeptides: ABB04_RS19955_lanthipeptide NZ_LDKE01000067.1 Lanthipeptides: ABB04_RS19940_lanthipeptide NZ_LDKE01000067.1 Lanthipeptides: ABB04_RS19935_lanthipeptide NZ_MOOT01000061.1 Lanthipeptides: BK765_RS23995_lanthipeptide NZ_MOOT01000061.1 Lanthipeptides: BK765_RS23990_lanthipeptide NZ_NVEA01000001.1 Lanthipeptides: COL15_RS00005_lanthipeptide NZ_PIYQ01000022.1 Lanthipeptides: CW365_RS08185_lanthipeptide NZ_PIYQ01000022.1 Lanthipeptides: CW365_RS08180_lanthipeptide NZ_PIYQ01000022.1 Lanthipeptides: CW365_RS08175_lanthipeptide NZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20670_lanthipeptide NZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20665_lanthipeptide NZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20660_lanthipeptide NZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20655_lanthipeptide NZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20650_lanthipeptide NZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20645_lanthipeptide NZ_WBPC01000027.1 Lanthipeptides: F8159_RS19555_lanthipeptide NZ_WBPC01000027.1 Lanthipeptides: F8159_RS19550_lanthipeptide NZ_WBPC01000027.1 Lanthipeptides: F8159_RS19545_lanthipeptide NZ_WBPC01000027.1 Lanthipeptides: F8159_RS19540_lanthipeptide NZ_WBPC01000027.1 Lanthipeptides: F8159_RS19535_lanthipeptide NZ_WBPC01000027.1 Lanthipeptides: F8159_RS19530_lanthipeptide NZ_WBPE01000025.1 Lanthipeptides: F8161_RS14445_lanthipeptide NZ_WBPE01000025.1 Lanthipeptides: F8161_RS14440_lanthipeptide NZ_WBPK01000016.1 Lanthipeptides: F8167_RS15680_lanthipeptide NZ_WBPK01000016.1 Lanthipeptides: F8167_RS15675_lanthipeptide NZ_WBPK01000016.1 Lanthipeptides: F8167_RS15670_lanthipeptide
Lanthipeptides: A9C19_RS17970_lanthipeptide
2
E N V N P M T T P V S P A P T V V I R V S L K V C
26
+V P T T P+ + + S+K+C
1
S D V Q P E T T P L C V G V I I G L T T S I K I C
25
22.9% NZ_CP036019.1 and 1 other:
NZ_CP036019.1 Lanthipeptides: EXW52_RS27165_lanthipeptide
Lanthipeptides: EXW52_RS27165_lanthipeptide
3
N V N P M T T P V S P A P T V V I R V S L K V C P T F
29
+V N P T P + P ++ ++ ++C P+
2
D V N P E T I P A T A T P-I L A N L T K E L C P S I
27
22.9% NZ_CP063142.1 and 1 other:
NZ_CP063142.1 Lanthipeptides: HPB58_RS21460_lanthipeptide
Lanthipeptides: HPB58_RS21460_lanthipeptide
16
T V V I R V S L K V C P T
28
T V I +S L C P T
8
T V T I P I S L A A C P T
20
22.9% NZ_CP063142.1 and 5 others:
NZ_CP063142.1 Lanthipeptides: HPB58_RS21455_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide
Lanthipeptides: HPB58_RS21455_lanthipeptide
16
T V V I R V S L K V C P T F K
30
T V I +S L C P T +
8
T V T I P I S L A A C P T T Q
22
22.9% NZ_CP101913.1 and 1 other:
NZ_CP101913.1 Lanthipeptides: NP440_RS09140_lanthipeptide
Lanthipeptides: NP440_RS09140_lanthipeptide
15
P T V V I R V S L K V C P T F K
30
P T V I +S +C P T +
8
P T V T I P I S A A I C P T T Q
23
22.9% NZ_KE384107.1: Lanthipeptides: G586_RS26715_lanthipeptide
11
V S P A P T V V I R V S L K V C P T F K
30
V+P ++I S C P T K
6
V A P V V P I I I A A S T A F C P T I K
25
22.9% NZ_KQ040792.1 and 1 other:
NZ_KQ040792.1 Lanthipeptides: WH45_RS23705_lanthipeptide
Lanthipeptides: WH45_RS23705_lanthipeptide
15
P T V V I R V S L K V C P T F K
30
P +I V S L +C P T +
9
P A T I I P V S L A I C P T T R
24
22.9% NZ_LDFC01000091.1: Lanthipeptides: ABE61_RS23570_lanthipeptide
13
P A P T V V I R V S L K V C
26
P P T V V V S+ +C
6
P P P T V V S S V S I W I C
19
22.9% NZ_LT985747.1: Lanthipeptides: C8268_RS22865_lanthipeptide
7
M T T P V S P A P T V V I R V S L K V C P T F K I K C K V
35
+ T P S + + + + C P T+ K C +
7
I C T P G S C S G N N C V L T T W R G C P T Y G P K C D I
35
22.9% NZ_NUML01000015.1: Lanthipeptides: COD66_RS20280_lanthipeptide
3
N V N P M T T P V S P A P T V V I R V S L K V C P T F
29
++N P T P +P P +++ ++ ++C P+
2
D M N P E T I P A T P T P-I L V N L T K E L C P S I
27
20.0% NZ_BQME02000001.1 and 5 others:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptide NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptide NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04085_lanthipeptide NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04085_lanthipeptide
Lanthipeptides: MFF31_RS04080_lanthipeptide
16
T V V I R V S L K V C P T F K
30
T++I +S L C P T +
6
T I I I P I S L A A C P T T R
20
18.9% NZ_CM001792.1 and 1 other:
NZ_CM001792.1 Lanthipeptides: C794_RS17975_lanthipeptide
Lanthipeptides: C794_RS17975_lanthipeptide
9
T P V S P A P T V V I R V S L K V C P T
28
+P++P+ + +S L C P T
8
S P L T P S S G S C V A I S L A F C P T
27
17.1% NZ_MJEJ02000054.1 and 3 others:
NZ_MJEJ02000054.1 Lanthipeptides: BH683_RS28810_lanthipeptide NZ_QJSP01000005.1 Lanthipeptides: DFR67_RS30760_lanthipeptide NZ_QJSP01000005.1 Lanthipeptides: DFR67_RS30760_lanthipeptide
Lanthipeptides: BH683_RS28810_lanthipeptide
21
V S L K V C P T F K
30
+S+ +C P T F K
12
L S V A L C P T F K
21
allorf_105014_105088
Leader:
MTGARTSGGA
Core:
C G L I R S N A K N L T R S
Core with dehydrations:
Cys G L I R Dha N A K N L Dhb R Dha

#### antiSMASH-DB 4.0 matches for allorf_105014_105088

100.0% NC_021362.1 and 11 others:
NZ_AP025342.1 Lanthipeptides: allorf_1476567_1476641_lanthipeptide NZ_AP026714.1 Lanthipeptides: allorf_1207193_1207267_lanthipeptide NZ_CP010524.1 Lanthipeptides: allorf_0181624_0181698_lanthipeptide NZ_CP020352.1 Lanthipeptides: allorf_0187351_0187425_lanthipeptide NZ_CP023168.1 Lanthipeptides: allorf_0187408_0187482_lanthipeptide NZ_CP039297.1 Lanthipeptides: allorf_0098046_0098120_lanthipeptide NZ_CP040672.1 Lanthipeptides: allorf_1092980_1093054_lanthipeptide NZ_CP059318.1 Lanthipeptides: allorf_0097981_0098055_lanthipeptide NZ_CP087137.1 Lanthipeptides: allorf_0097877_0097951_lanthipeptide NZ_CP118744.1 Lanthipeptides: allorf_0187316_0187390_lanthipeptide NZ_NGMV01000001.1 Lanthipeptides: allorf_1660067_1660141_lanthipeptide
Lanthipeptides: allorf_0181474_0181548_lanthipeptide
1
C G L I R S N A K N L T R S
14
C G L I R S N A K N L T R S
1
C G L I R S N A K N L T R S
14
78.6% NZ_CP051884.1: Lanthipeptides: allorf_3277830_3277904_lanthipeptide
1
C G L I R S N A K N L T R S
14
C G L I R N A K N L T++
1
C G L I R C N A K N L T K A
14
allorf_105836_105952
Leader:
MDALALGADEGRDEHRYA
Core:
S G S C K Q A L I R R F P N G E T H H S
Core with dehydrations:
Dha G Dha Cys K Q A L I R R F P N G E Dhb H H Dha

#### antiSMASH-DB 4.0 matches for allorf_105836_105952

100.0% NZ_CP039297.1 and 3 others:
NZ_CP040672.1 Lanthipeptides: allorf_1093859_1093975_lanthipeptide NZ_CP059318.1 Lanthipeptides: allorf_0098860_0098976_lanthipeptide NZ_CP087137.1 Lanthipeptides: allorf_0098698_0098814_lanthipeptide
Lanthipeptides: allorf_0098925_0099041_lanthipeptide
1
S G S C K Q A L I R R F P N G E T H H S
20
S G S C K Q A L I R R F P N G E T H H S
1
S G S C K Q A L I R R F P N G E T H H S
20
30.0% NZ_CP119804.1: Lanthipeptides: allorf_1905850_1905972_lanthipeptide
9
I R R F P N G E T H H S
20
I R F ++H H S
3
I N R F A R C D S H H S
14
20.8% NZ_KZ559472.1: Lanthipeptides: CXR44_RS39555_lanthipeptide
3
S C K Q A L I R R F P
13
+C K+ + R F P
8
T C K R T V C S R F P
18
allorf_106877_107011
Leader:
MIRLAPVHFRRRVTRPVSYYA
Core:
L F K W W L L L S Q H P G C L S N S T S F S T
Core with dehydrations:
L F K W W L L L Dha Q H P G Cys L Dha N Dha Dhb Dha F Dha Dhb

#### antiSMASH-DB 4.0 matches for allorf_106877_107011

100.0% NZ_CP039297.1 and 3 others:
NZ_CP040672.1 Lanthipeptides: allorf_1094900_1095034_lanthipeptide NZ_CP059318.1 Lanthipeptides: allorf_0099901_0100035_lanthipeptide NZ_CP087137.1 Lanthipeptides: allorf_0099739_0099873_lanthipeptide
Lanthipeptides: allorf_0099966_0100100_lanthipeptide
1
L F K W W L L L S Q H P G C L S N S T S F S T
23
L F K W W L L L S Q H P G C L S N S T S F S T
1
L F K W W L L L S Q H P G C L S N S T S F S T
23
95.7% NZ_CM000721.1: Lanthipeptides: allorf_5216161_5216295_lanthipeptide
1
L F K W W L L L S Q H P G C L S N S T S F S T
23
L F K W W L L L S Q H P C L S N S T S F S T
1
L F K W W L L L S Q H P S C L S N S T S F S T
23
19.4% NC_015711.1: Lanthipeptides: allorf_5704565_5704741_lanthipeptide
7
L L S Q H P G C L S N S
18
L+S +P G C L+++
20
L V S S N P G C L A S A
31
with 1 more sequence matches
16.7% NZ_QKUF01000048.1: Lanthipeptides: EI42_RS30000_lanthipeptide
12
P G C L S N S T
19
P G C L+N+T
9
P G C L T N N T
16
allorf_108495_108641
Leader:
MRNGKSHLEGG
Core:
F M L R C F Q H L S R P H I A T Q R C P W Q N N W Y T S G A S I P V L S Y
Core with dehydrations:
F M L R Cys F Q H L Dha R P H I A Dhb Q R Cys P W Q N N W Y Dhb Dha G A Dha I P V L Dha Y

#### antiSMASH-DB 4.0 matches for allorf_108495_108641

100.0% NZ_CP039297.1 and 3 others:
NZ_CP040672.1 Lanthipeptides: allorf_1096518_1096664_lanthipeptide NZ_CP059318.1 Lanthipeptides: allorf_0101519_0101665_lanthipeptide NZ_CP087137.1 Lanthipeptides: allorf_0101357_0101503_lanthipeptide
Lanthipeptides: allorf_0101584_0101730_lanthipeptide
1
F M L R C F Q H L S R P H I A T Q R C P W Q N N W Y T S G A S I P V L S Y
37
F M L R C F Q H L S R P H I A T Q R C P W Q N N W Y T S G A S I P V L S Y
1
F M L R C F Q H L S R P H I A T Q R C P W Q N N W Y T S G A S I P V L S Y
37
24.4% NZ_CP070036.1 and 2 others:
NZ_JADMPO010000043.1 Lanthipeptides: I2I27_RS16845_lanthipeptide NZ_JAQMLK010000037.1 Lanthipeptides: PNW18_RS16700_lanthipeptide
Lanthipeptides: I6K72_RS03930_lanthipeptide
2
M L R C F Q H L S R P H I A T Q R C P W Q N N W
25
M R Q L S H R C W+ +W
10
M E R I K Q L L S-E H S Q M F R C S W R K S W
32
20.5% NZ_BMRY01000003.1 and 1 other:
NZ_BMRY01000003.1 Lanthipeptides: allorf_458543_458737_lanthipeptide
Lanthipeptides: allorf_458543_458737_lanthipeptide
3
L R C-F Q H L S R P H I A T Q R C P W
21
L R C F P + R C P W
13
L R C P F V R P P S P L L L R P R C P W
32
with 3 more sequence matches
18.9% NZ_LT630004.1: Lanthipeptides: allorf_2780249_2780374_lanthipeptide
19
C P W Q N N W Y T S G A S I P V
34
C P++N N Y G +P+
11
C P Y R N N I Y--G T F L P L
24
18.0% NZ_JACKVL010000013.1: Lanthipeptides: allorf_1185244_1185420_lanthipeptide
9
L S R P H I A T Q R C P W Q N N W Y T S G A S I P V
34
L R +A +R P +W T S +I +
4
L V R L A V A A K R M P A G A S W T T S T G N I E I
29
13.5% NZ_LR134301.1: Lanthipeptides: allorf_1738566_1738781_lanthipeptide
19
C P W Q N N W Y T S G
29
C P W W G
4
C P W P G G W V V Q G
14
allorf_108748_108939
Leader:
MYAYCYLVLREHSQWFGG
Core:
D S E E V T P V P M P N T E V K L F S A D G S R G F S P C E S R T P P S Y H Y G K G S S S
Core with dehydrations:
D Dha E E V Dhb P V P M P N Dhb E V K L F Dha A D G Dha R G F Dha P Cys E Dha R Dhb P P Dha Y H Y G K G Dha Dha Dha

#### antiSMASH-DB 4.0 matches for allorf_108748_108939

47.4% NZ_CP039297.1 and 2 others:
NZ_CP040672.1 Lanthipeptides: allorf_1096771_1096998_lanthipeptide NZ_CP087137.1 Lanthipeptides: allorf_0101610_0101837_lanthipeptide
Lanthipeptides: allorf_0101837_0102064_lanthipeptide
1
D S E E V T P V P M P N T E V K L F S A D G S R G F S P C E
30
D S E E V T P V P M P N T E V K L F S A D G S R G F P
1
D S E E V T P V P M P N T E V K L F S A D G S R G F P P V R
30
47.4% NZ_CP059318.1: Lanthipeptides: allorf_0101772_0101999_lanthipeptide
1
D S E E V T P V P M P N T E V K L F S A D G S R G F S P C E
30
D S E E V T P V P M P N T E V K L F S A D G S R G F P
1
D S E E V T P V P M P N T E V K L F S A D G S R G F L P V R
30
22.2% NZ_CP036019.1 and 1 other:
NZ_CP036019.1 Lanthipeptides: EXW52_RS27200_lanthipeptide
Lanthipeptides: EXW52_RS27200_lanthipeptide
23
S R G F S P C E S R T P P S Y H Y G K G S S S
45
S G C E R S Y Y G S
9
S S G C G R C E P R N D S S Y T Y N C G G K S
31
with 3 more sequence matches
20.0% NZ_AP025692.1 and 8 others:
NZ_AP025692.1 Lanthipeptides: allorf_0069478_0069666_lanthipeptide NZ_CP056773.1 Lanthipeptides: allorf_6887512_6887700_lanthipeptide NZ_CP056773.1 Lanthipeptides: allorf_6887512_6887700_lanthipeptide NZ_JAHUVY010000001.1 Lanthipeptides: allorf_0075041_0075244_lanthipeptide NZ_JAHUVY010000001.1 Lanthipeptides: allorf_0075041_0075244_lanthipeptide NZ_OX371412.1 Lanthipeptides: allorf_0056080_0056268_lanthipeptide NZ_VOGX01000034.1 Lanthipeptides: allorf_1079300_1079488_lanthipeptide NZ_VOGX01000034.1 Lanthipeptides: allorf_1079300_1079488_lanthipeptide
Lanthipeptides: allorf_0069478_0069666_lanthipeptide
28
P C-E S R T P P S Y H Y G K G
42
P C +R T P P H G G
8
P C G W A R T P P R G H S G T G
23
20.0% NZ_QOIL01000017.1: Lanthipeptides: allorf_026474_026683_lanthipeptide
23
S R G F S P C E S R T P P S Y H Y G
40
S R P C+ R P P S +G
2
S R L A P P C Q G R R P P S A C H G
19
11.1% NZ_NAQX01000046.1: Lanthipeptides: B8A46_RS06340_lanthipeptide
16
K L F S A D G S R G F S P C E S R T
33
K+F D G + C++++
3
K V F D L D G E E N Y C Y C D N Q S
20
allorf_108766_108915
Leader:
MIAWRRPTLTGG
Core:
K P P T T I G A E E L N F R V R H G N G C D L F A I A T K P L R V F S Q N
Core with dehydrations:
K P P Dhb Dhb I G A E E L N F R V R H G N G Cys D L F A I A Dhb K P L R V F Dha Q N

#### antiSMASH-DB 4.0 matches for allorf_108766_108915

18.9% NZ_CP060140.1 and 1 other:
NZ_VIKW01000003.1 Lanthipeptides: FJR04_RS03310_lanthipeptide
Lanthipeptides: BDGGKGIB_RS05565_lanthipeptide
6
I G A E E L N F
13
I G A E E L+F
18
I G A E E L S F
25
18.9% NZ_VLKB01000010.1: Lanthipeptides: allorf_1593188_1593316_lanthipeptide
6
I G A E E L N F R V R H G N G C
21
I A +N F + +G G C
2
I P A R P I N F N I T N G Q G C
17
10.2% NC_021055.1 and 3 others:
NC_021055.1 Lanthipeptides: allorf_2673515_2673721_lanthipeptide NZ_CP038147.1 Lanthipeptides: allorf_2285811_2286017_lanthipeptide NZ_CP038147.1 Lanthipeptides: allorf_2285811_2286017_lanthipeptide
Lanthipeptides: allorf_2673515_2673721_lanthipeptide
4
T T I G A E E L N F R V R H G N
19
+ +G A + +R R H G+
36
S G M G A A Q A A Y R T R H G S
51
allorf_108794_108976
Leader:
MVAIAKRSHPFPCRTRKLSSSAPMVVGG
Core:
F P P V R V G R R Q A I I T V K A A H H E L P F L C F S A Y V I
Core with dehydrations:
F P P V R V G R R Q A I I Dhb V K A A H H E L P F L Cys F Dha A Y V I

#### antiSMASH-DB 4.0 matches for allorf_108794_108976

56.1% NZ_CP039297.1 and 1 other:
NZ_CP087137.1 Lanthipeptides: allorf_0101610_0101837_lanthipeptide
Lanthipeptides: allorf_0101837_0102064_lanthipeptide
1
F P P V R V G R R Q A I I T V K A A H H E L P F L C F S A Y V I
32
F P P V R V G R R Q A I I T V K A A H H E L P F L C F S A Y V I
26
F P P V R V G R R Q A I I T V K A A H H E L P F L C F S A Y V I
57
54.4% NZ_CP040672.1: Lanthipeptides: allorf_1096771_1096998_lanthipeptide
1
F P P V R V G R R Q A I I T V K A A H H E L P F L C F S A Y V I
32
F P P V R V G R R Q A I I+V K A A H H E L P F L C F S A Y V I
26
F P P V R V G R R Q A I I S V K A A H H E L P F L C F S A Y V I
57
54.4% NZ_CP059318.1: Lanthipeptides: allorf_0101772_0101999_lanthipeptide
1
F P P V R V G R R Q A I I T V K A A H H E L P F L C F S A Y V I
32
F P V R V G R R Q A I I T V K A A H H E L P F L C F S A Y V I
26
F L P V R V G R R Q A I I T V K A A H H E L P F L C F S A Y V I
57
allorf_108936_109136
Leader:
MSCLFCVFLHTLYNM
Core:
R N V T I C L F A K A G F M L V Q S G N N R D R A I Q L K N F A K H L I V R L K S N I V K V N E G G G
Core with dehydrations:
R N V Dhb I Cys L F A K A G F M L V Q Dha G N N R D R A I Q L K N F A K H L I V R L K Dha N I V K V N E G G G

#### antiSMASH-DB 4.0 matches for allorf_108936_109136

100.0% NZ_CP059318.1: Lanthipeptides: allorf_0101959_0102159_lanthipeptide
1
R N V T I C L F A K A G F M L V Q S G N N R D R A I Q L K N F A K H L I V R L K S N I V K V N E G G G
51
R N V T I C L F A K A G F M L V Q S G N N R D R A I Q L K N F A K H L I V R L K S N I V K V N E G G G
1
R N V T I C L F A K A G F M L V Q S G N N R D R A I Q L K N F A K H L I V R L K S N I V K V N E G G G
51
98.0% NZ_CP039297.1: Lanthipeptides: allorf_0102024_0102224_lanthipeptide
1
R N V T I C L F A K A G F M L V Q S G N N R D R A I Q L K N F A K H L I V R L K S N I V K V N E G G G
51
R N V T I C L F A K A G F M L V Q S G N N R D R A I Q L K N F A K H L I V R L K S N I V K V N+G G G
1
R N V T I C L F A K A G F M L V Q S G N N R D R A I Q L K N F A K H L I V R L K S N I V K V N K G G G
51
96.1% NZ_CP040378.1: Lanthipeptides: allorf_0072224_0072424_lanthipeptide
1
R N V T I C L F A K A G F M L V Q S G N N R D R A I Q L K N F A K H L I V R L K S N I V K V N E G G G
51
R N V T I C L F A K A G F M L V Q S G N N R D R A I Q L K N F A K H I V R L K S N I V K V N+G G G
1
R N V T I C L F A K A G F M L V Q S G N N R D R A I Q L K N F A K H F I V R L K S N I V K V N K G G G
51
with 4 more sequence matches
96.1% NZ_CP040672.1: Lanthipeptides: allorf_1096958_1097158_lanthipeptide
1
R N V T I C L F A K A G F M L V Q S G N N R D R A I Q L K N F A K H L I V R L K S N I V K V N E G G G
51
R N V T I C L F A K A G F M L V Q S G N N R D R A I Q L K N F A K L I V R L K S N I V K V N+G G G
1
R N V T I C L F A K A G F M L V Q S G N N R D R A I Q L K N F A K R L I V R L K S N I V K V N K G G G
51
15.7% NZ_CP011130.1: Lanthipeptides: allorf_4095947_4096132_lanthipeptide
9
A K A G F M L V Q S G N N R D R
24
A K A + +S G +R D R
9
A K A T W P T C R S G A S R D R
24
15.7% NZ_CP023465.1: Lanthipeptides: allorf_4137774_4138001_lanthipeptide
9
A K A G F M L V Q S G N N R D R A I
26
A+A + +S G +R D R I
8
A E A T W P T C R S G A S R D R D I
25
11.3% NZ_VITV01000003.1: Lanthipeptides: FBZ87_RS11200_lanthipeptide
6
C L F A K A G F M L V
16
C A K A G F M++
49
C D S A K A G F M V I
59

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Lanthipeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

ctg1_108 - Class II
  Cleavage pHMM score: -3.30
  RODEO score: 0
  Monoisotopic mass: 3716.1 Da
  Molecular weight: 3718.5 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3736.5 Da N = 1
    3754.5 Da N = 2
    3772.5 Da N = 3
    3790.6 Da N = 4
allorf_105014_105088 - Class II
  Cleavage pHMM score: -3.80
  RODEO score: 0
  Monoisotopic mass: 1477.8 Da
  Molecular weight: 1478.7 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1496.7 Da N = 1
    1514.7 Da N = 2
allorf_105836_105952 - Class II
  Cleavage pHMM score: -6.20
  RODEO score: 0
  Monoisotopic mass: 2152.1 Da
  Molecular weight: 2153.4 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2171.4 Da N = 1
    2189.4 Da N = 2
    2207.4 Da N = 3
allorf_106877_107011 - Class II
  Cleavage pHMM score: -6.80
  RODEO score: 0
  Monoisotopic mass: 2525.3 Da
  Molecular weight: 2526.9 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2544.9 Da N = 1
    2562.9 Da N = 2
    2580.9 Da N = 3
    2599.0 Da N = 4
    2617.0 Da N = 5
    2635.0 Da N = 6
allorf_108495_108641 - Class II
  Cleavage pHMM score: -5.00
  RODEO score: 0
  Monoisotopic mass: 4299.1 Da
  Molecular weight: 4301.9 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4319.9 Da N = 1
    4337.9 Da N = 2
    4356.0 Da N = 3
    4374.0 Da N = 4
allorf_108748_108939 - Class II
  Cleavage pHMM score: -3.20
  RODEO score: 0
  Monoisotopic mass: 4600.2 Da
  Molecular weight: 4602.9 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4620.9 Da N = 1
    4639.0 Da N = 2
    4657.0 Da N = 3
    4675.0 Da N = 4
    4693.0 Da N = 5
    4711.0 Da N = 6
    4729.1 Da N = 7
    4747.1 Da N = 8
    4765.1 Da N = 9
    4783.1 Da N = 10
    4801.1 Da N = 11
allorf_108766_108915 - Class II
  Cleavage pHMM score: -4.60
  RODEO score: 0
  Monoisotopic mass: 4024.1 Da
  Molecular weight: 4026.6 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4044.6 Da N = 1
    4062.6 Da N = 2
    4080.6 Da N = 3
allorf_108794_108976 - Class II
  Cleavage pHMM score: -4.90
  RODEO score: 0
  Monoisotopic mass: 3599.0 Da
  Molecular weight: 3601.3 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3619.3 Da N = 1
allorf_108936_109136 - Class II
  Cleavage pHMM score: -5.60
  RODEO score: 0
  Monoisotopic mass: 5583.1 Da
  Molecular weight: 5586.5 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    5604.6 Da N = 1
    5622.6 Da N = 2

gnlProkkaMDFAHGHL_2 - Region 1 - NRPS,betalactone,transAT-PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 81,859 - 219,690 nt. (total: 137,832 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
KnownClusterBlast
NRPS/PKS modules
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 81858 - 219690:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Glu - D-Orn) + (D-Thr) + (Glu - D-X) + (Pro - Gln) + (Ile) + (mal - Asn) + (D-Tyr - D-Asn - Pro - Glu) + (Ser) + (Thr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 81858 - 159110:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (mal - Asn) + (D-Tyr - D-Asn - Pro - Glu) + (Ser) + (Thr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 142021 - 219690:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Glu - D-Orn) + (D-Thr) + (Glu - D-X) + (Pro - Gln) + (Ile)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg2_112: Thr
  Search NORINE for peptide: strict or relaxed
  AMP-binding (819..1218): Thr
  nrpys: Thr
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
    Small clusters prediction:
      thr (Thr)
    Single AA prediction:
      thr (Thr)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DFWNIGMVHK
    Nearest Stachelhaus code(s):
      Thr DFWNIGMVHK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
ctg2_113: Ser
  Search NORINE for peptide: strict or relaxed
  AMP-binding (267..674): Ser
  nrpys: Ser
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
    Small clusters prediction:
      ser (Ser)
    Single AA prediction:
      ser (Ser)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVWHFSLIDK
    Nearest Stachelhaus code(s):
      Ser DVWHFSLIDK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
ctg2_114: Tyr - Asn - Pro - Glu
  Search NORINE for peptide: strict or relaxed
  AMP-binding (268..662): Tyr
  nrpys: Tyr
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
    Large clusters prediction:
      Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
    Small clusters prediction:
      Polar aromatic ring (Tyr, bOH-Tyr)
    Single AA prediction:
      tyr (Tyr)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DALSVGEVVK
    Nearest Stachelhaus code(s):
      Tyr DALSVGEVVK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1779..2174): Asn
  nrpys: Asn
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
    Large clusters prediction:
      Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
    Small clusters prediction:
      asp,asn (Asp, Asn)
    Single AA prediction:
      asn (Asn)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLTKIGEVGK
    Nearest Stachelhaus code(s):
      Asn DLTKIGEVGK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
  AMP-binding (3286..3683): Pro
  nrpys: Pro
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
    Small clusters prediction:
      pro (Pro)
    Single AA prediction:
      pro (Pro)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVQFIAHVVK
    Nearest Stachelhaus code(s):
      Pro DVQFIAHVVK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
  AMP-binding (4325..4732): Glu
  nrpys: Glu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
    Large clusters prediction:
      Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
    Small clusters prediction:
      glu,gln (Glu, Gln)
    Single AA prediction:
      gln (Gln)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAKDLGVVDK
    Nearest Stachelhaus code(s):
      Glu DAKDLGVVDK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
ctg2_115: pk - Asn
  Search NORINE for peptide: strict or relaxed
  CAL_domain (36..478): pk
  minowa: fatty_acid
  Prediction, score:
    fatty_acid: 623.2
    NH2: 18.6
    shikimic_acid: 0.0
    Acetyl-CoA: 0.0
    AHBA: 0.0
  AMP-binding (2956..3351): Asn
  nrpys: Asn
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
    Large clusters prediction:
      Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
    Small clusters prediction:
      asp,asn (Asp, Asn)
    Single AA prediction:
      asn (Asn)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLTKIGEVGK
    Nearest Stachelhaus code(s):
      Asn DLTKIGEVGK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
ctg2_116: mal
  PKS_AT (6..290): mal
  ATSignature: Malonyl-CoA
  Top 3 matches:
    Malonyl-CoA: 62.5%
    inactive: 54.2%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 75.7
    inactive: 30.0
    Methoxymalonyl-CoA: 20.4
    Propionyl-CoA: 11.8
    Methylmalonyl-CoA: 11.0
    trans-1,2-CPDA: 0.0
    fatty_acid: 0.0
    Isobutyryl-CoA: 0.0
    Ethylmalonyl-CoA: 0.0
    CHC-CoA: 0.0
    Benzoyl-CoA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
    2-Methylbutyryl-CoA: 0.0
ctg2_135: X
  AMP-binding (12..445): X
  nrpys: Asp, Asn, Glu, Gln, Aad
  SVM prediction details:
    Predicted physicochemical class:
      N/A
    Large clusters prediction:
      Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      -GLHIAAPVK
    Nearest Stachelhaus code(s):
      Z-ahmohOrn FGLHIASTCK (56% 8Å match)
      Ile DGLFIGIPVK (32% 8Å match)
    Stachelhaus code match:
      60% (weak)
ctg2_139: Ile
  Search NORINE for peptide: strict or relaxed
  AMP-binding (473..866): Ile
  nrpys: Ile
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
    Small clusters prediction:
      Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
    Single AA prediction:
      ile (Ile)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAFFYGITFK
    Nearest Stachelhaus code(s):
      Ile DAFFYGITFK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
ctg2_141: Pro - Gln - Tyr
  Search NORINE for peptide: strict or relaxed
  AMP-binding (469..866): Pro
  nrpys: Pro
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
    Small clusters prediction:
      pro (Pro)
    Single AA prediction:
      pro (Pro)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVQFIAHVVK
    Nearest Stachelhaus code(s):
      Pro DVQFIAHVVK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1500..1901): Gln
  nrpys: Gln
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
    Large clusters prediction:
      Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
    Small clusters prediction:
      glu,gln (Glu, Gln)
    Single AA prediction:
      glu (Glu)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAWHFGSVEK
    Nearest Stachelhaus code(s):
      Gln DAWHFGSVEK (100% 8Å match)
      Glu DAWHFGSVEK (94% 8Å match)
    Stachelhaus code match:
      100% (strong)
  AMP-binding (2532..2924): Tyr
  nrpys: Tyr
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
    Large clusters prediction:
      Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
    Small clusters prediction:
      Polar aromatic ring (Tyr, bOH-Tyr)
    Single AA prediction:
      tyr (Tyr)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DGTITAEVAK
    Nearest Stachelhaus code(s):
      Tyr DGTITAEVAK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
ctg2_142: Glu - X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (468..873): Glu
  nrpys: Glu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
    Large clusters prediction:
      Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
    Small clusters prediction:
      glu,gln (Glu, Gln)
    Single AA prediction:
      glu (Glu)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAWHFGGVDK
    Nearest Stachelhaus code(s):
      Glu DAWHFGGVDK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1505..1898): X
  nrpys: Ala, Val
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
    Small clusters prediction:
      Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
    Single AA prediction:
      val (Val)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVFWIGGTFK
    Nearest Stachelhaus code(s):
      Ala or Val DVFWIGGTFK (100% 8Å match)
      Val DVFWIGGTFK (91% 8Å match)
    Stachelhaus code match:
      100% (strong)
ctg2_143: Thr
  Search NORINE for peptide: strict or relaxed
  AMP-binding (831..1227): Thr
  nrpys: Thr
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
    Small clusters prediction:
      thr (Thr)
    Single AA prediction:
      thr (Thr)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DFWNIGMVHK
    Nearest Stachelhaus code(s):
      Thr DFWNIGMVHK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
ctg2_145: Glu - Orn
  Search NORINE for peptide: strict or relaxed
  AMP-binding (2..253): Glu
  nrpys: Glu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
    Large clusters prediction:
      Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
    Small clusters prediction:
      glu,gln (Glu, Gln)
    Single AA prediction:
      glu (Glu)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAWHFGGVDK
    Nearest Stachelhaus code(s):
      Glu DAWHFGGVDK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
  AMP-binding (885..1290): Orn
  nrpys: Orn
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
    Large clusters prediction:
      Long positively charged side chain (Orn, Lys, Arg)
    Small clusters prediction:
      Orn and hydroxy-Orn specific (Orn, OH-Orn)
    Single AA prediction:
      orn (Orn)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVGEVGSIDK
    Nearest Stachelhaus code(s):
      Orn DVGEVGSIDK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)

gnlProkkaMDFAHGHL_3 - Region 1 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 8,210 - 30,093 nt. (total: 21,884 nt) Show pHMM detection rules used
Region on contig edge.
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
KnownClusterBlast
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

gnlProkkaMDFAHGHL_5 - Region 1 - T3PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 895 - 42,139 nt. (total: 41,245 nt) Show pHMM detection rules used
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
KnownClusterBlast
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

NRPS/PKS substrates
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

gnlProkkaMDFAHGHL_5 - Region 2 - transAT-PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 159,479 - 263,800 nt. (total: 104,322 nt) Show pHMM detection rules used
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
KnownClusterBlast
NRPS/PKS modules
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 2, location 159478 - 263800:
Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:
  (ohmal) + (ccmal) + (ohmal - mal) + (Me-ccmal) + (mal) + (Me-ccmal) + (mal) + (ccmal) + (mal) + (ohmal - mal)
Non-colinear ordering:
  ctg5_220 + ctg5_219 + ctg5_218 + ctg5_217 + ctg5_216 + ctg5_215 + ctg5_228 + ctg5_223 + ctg5_222 + ctg5_226 + ctg5_225 + ctg5_224

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg5_230: X
  AMP-binding (15..363): X
  nrpys: (unknown)
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      IGNPTGTIFK
    Nearest Stachelhaus code(s):
      2,3-dohHda IGNPTGTIMK (76% 8Å match)
    Stachelhaus code match:
      90% (moderate)
ctg5_234: mal
  PKS_AT (4..281): mal
  ATSignature: Malonyl-CoA
  Top 3 matches:
    Malonyl-CoA: 83.3%
    inactive: 62.5%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 87.7
    inactive: 30.9
    Methoxymalonyl-CoA: 29.3
    Methylmalonyl-CoA: 21.7
    Propionyl-CoA: 16.5
    2-Methylbutyryl-CoA: 15.4
    trans-1,2-CPDA: 0.0
    fatty_acid: 0.0
    Isobutyryl-CoA: 0.0
    Ethylmalonyl-CoA: 0.0
    CHC-CoA: 0.0
    Benzoyl-CoA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0

gnlProkkaMDFAHGHL_7 - Region 1 - NRP-metallophore,NRPS,RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 65,773 - 117,560 nt. (total: 51,788 nt) Show pHMM detection rules used
NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX))
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
KnownClusterBlast
NRPS/PKS modules
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 65772 - 117560:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Gly) + (Thr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 65772 - 117507:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Gly) + (Thr)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg7_94: Thr
  Search NORINE for peptide: strict or relaxed
  AMP-binding (392..808): Thr
  nrpys: Thr
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
    Small clusters prediction:
      thr (Thr)
    Single AA prediction:
      thr (Thr)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DFWNIGMVHK
    Nearest Stachelhaus code(s):
      Thr DFWNIGMVHK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
ctg7_95: Gly
  Search NORINE for peptide: strict or relaxed
  AMP-binding (456..855): Gly
  nrpys: Gly
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
    Small clusters prediction:
      Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
    Single AA prediction:
      gly (Gly)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DILQLGLIWK
    Nearest Stachelhaus code(s):
      Gly DILQLGLIWK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
ctg7_97: diOH-Bz
  Search NORINE for peptide: strict or relaxed
  AMP-binding (31..435): diOH-Bz
  nrpys: diOH-Bz
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
    Large clusters prediction:
      Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
    Small clusters prediction:
      Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
    Single AA prediction:
      dhb (diOH-Bz)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      PLPAQGVVNK
    Nearest Stachelhaus code(s):
      diOH-Bz PLPAQGVVNK (100% 8Å match)
      diOH-Bz or Sal PLPAQGVVNK (94% 8Å match)
    Stachelhaus code match:
      100% (strong)

gnlProkkaMDFAHGHL_8 - Region 1 - other
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 502,321 - 543,739 nt. (total: 41,419 nt) Show pHMM detection rules used
other: (LmbU or Neocarzinostat or bcpB or frbD or mitE or vlmB or prnB or CaiA or bacilysin or orf2_PTase)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
KnownClusterBlast
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
gnlProkkaMDFAHGHL_9 - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 11,832 - 77,240 nt. (total: 65,409 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
KnownClusterBlast
NRPS/PKS modules
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 11831 - 77240:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Glu - Leu - Leu) + (Val) + (Asp - D-Leu) + (Leu)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg9_32: Glu - Leu - Leu
  Search NORINE for peptide: strict or relaxed
  AMP-binding (465..867): Glu
  nrpys: Glu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
    Large clusters prediction:
      Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
    Small clusters prediction:
      glu,gln (Glu, Gln)
    Single AA prediction:
      gln (Gln)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAKDLGVVDK
    Nearest Stachelhaus code(s):
      Glu DAKDLGVVDK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1511..1908): Leu
  nrpys: Leu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
    Small clusters prediction:
      Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
    Single AA prediction:
      leu (Leu)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAFMMGMVFK
    Nearest Stachelhaus code(s):
      Leu DAFMMGMVFK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
  AMP-binding (2550..2939): Leu
  nrpys: Leu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
    Small clusters prediction:
      Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
    Single AA prediction:
      leu (Leu)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAWFLGNVVK
    Nearest Stachelhaus code(s):
      Leu DAWFLGNVVK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
ctg9_35: Val
  Search NORINE for peptide: strict or relaxed
  AMP-binding (470..864): Val
  nrpys: Val
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
    Small clusters prediction:
      Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
    Single AA prediction:
      val (Val)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAFWIGGTFK
    Nearest Stachelhaus code(s):
      Val DAFWIGGTFK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
ctg9_36: Asp - Leu
  Search NORINE for peptide: strict or relaxed
  AMP-binding (112..514): Asp
  nrpys: Asp
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
    Large clusters prediction:
      Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
    Small clusters prediction:
      asp,asn (Asp, Asn)
    Single AA prediction:
      asp (Asp)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLTKVGHIGK
    Nearest Stachelhaus code(s):
      Asp DLTKVGHIGK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1157..1546): Leu
  nrpys: Leu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
    Small clusters prediction:
      Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
    Single AA prediction:
      leu (Leu)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAWFLGNVVK
    Nearest Stachelhaus code(s):
      Leu DAWFLGNVVK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
ctg9_37: Leu
  Search NORINE for peptide: strict or relaxed
  AMP-binding (469..867): Leu
  nrpys: Leu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
    Small clusters prediction:
      Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
    Single AA prediction:
      leu (Leu)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAFFLGCVFK
    Nearest Stachelhaus code(s):
      Leu DAFFLGCVFK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)

gnlProkkaMDFAHGHL_14 - Region 1 - PKS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 175,458 - 216,702 nt. (total: 41,245 nt) Show pHMM detection rules used
PKS-like: (t2pks2 or ksIII)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
KnownClusterBlast
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
gnlProkkaMDFAHGHL_14 - Region 2 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 299,485 - 320,225 nt. (total: 20,741 nt) Show pHMM detection rules used
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
KnownClusterBlast
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

gnlProkkaMDFAHGHL_16 - Region 1 - transAT-PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 133,835 - 222,063 nt. (total: 88,229 nt) Show pHMM detection rules used
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
KnownClusterBlast
NRPS/PKS modules
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 133834 - 222063:
Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:
  (ohmal - ccmal) + (ccmal - mal) + (ohmal) + (ohmal - mal) + (ccmal) + (mal)
Non-colinear ordering:
  ctg16_168 + ctg16_169 + ctg16_175 + ctg16_176 + ctg16_177 + ctg16_178 + ctg16_173 + ctg16_174

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg16_167: mal
  PKS_AT (4..282): mal
  ATSignature: Malonyl-CoA
  Top 3 matches:
    Malonyl-CoA: 75.0%
    inactive: 62.5%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 91.9
    inactive: 31.2
    Methoxymalonyl-CoA: 26.1
    Methylmalonyl-CoA: 19.6
    Propionyl-CoA: 16.9
    fatty_acid: 13.9
    trans-1,2-CPDA: 0.0
    Isobutyryl-CoA: 0.0
    Ethylmalonyl-CoA: 0.0
    CHC-CoA: 0.0
    Benzoyl-CoA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
    2-Methylbutyryl-CoA: 0.0

gnlProkkaMDFAHGHL_16 - Region 2 - NRPS,NRPS-like,T3PKS,transAT-PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 443,342 - 536,922 nt. (total: 93,581 nt) Show pHMM detection rules used
Region on contig edge.
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)
NRPS: cds(Condensation and (AMP-binding or A-OX))
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
KnownClusterBlast
NRPS/PKS modules
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 2, location 443341 - 536922:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Gly - ccmal - ohmal - mal) + (ccmal - mal - ohmal - mal) + (Me-ccmal - ohmal) + (Ala - ccmal - ccmal - Me-ccmal) + (mal - mal)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg16_440: mal
  PKS_AT (4..285): mal
  ATSignature: Malonyl-CoA
  Top 3 matches:
    Malonyl-CoA: 87.5%
    inactive: 62.5%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 100.0
    inactive: 46.8
    Methoxymalonyl-CoA: 38.9
    Methylmalonyl-CoA: 25.3
    Propionyl-CoA: 23.1
    trans-1,2-CPDA: 0.0
    fatty_acid: 0.0
    Isobutyryl-CoA: 0.0
    Ethylmalonyl-CoA: 0.0
    CHC-CoA: 0.0
    Benzoyl-CoA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
    2-Methylbutyryl-CoA: 0.0
ctg16_441: mal
  PKS_AT (7..293): mal
  ATSignature: (unknown)
  No matches above 50%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 31.9
    inactive: 26.1
    Methoxymalonyl-CoA: 16.2
    Benzoyl-CoA: 14.0
    Methylmalonyl-CoA: 9.1
    Isobutyryl-CoA: 8.8
    trans-1,2-CPDA: 0.0
    fatty_acid: 0.0
    Propionyl-CoA: 0.0
    Ethylmalonyl-CoA: 0.0
    CHC-CoA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
    2-Methylbutyryl-CoA: 0.0
ctg16_442: mal
  PKS_AT (4..282): mal
  ATSignature: Malonyl-CoA
  Top 3 matches:
    Malonyl-CoA: 91.7%
    inactive: 66.7%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 89.6
    inactive: 28.2
    Methoxymalonyl-CoA: 21.6
    trans-1,2-CPDA: 0.0
    fatty_acid: 0.0
    Propionyl-CoA: 0.0
    Methylmalonyl-CoA: 0.0
    Isobutyryl-CoA: 0.0
    Ethylmalonyl-CoA: 0.0
    CHC-CoA: 0.0
    Benzoyl-CoA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
    2-Methylbutyryl-CoA: 0.0
ctg16_448: pk - Gly
  Search NORINE for peptide: strict or relaxed
  CAL_domain (0..396): pk
  minowa: fatty_acid
  Prediction, score:
    fatty_acid: 23.9
    NH2: 9.4
    shikimic_acid: 0.0
    Acetyl-CoA: 0.0
    AHBA: 0.0
  AMP-binding (1065..1460): Gly
  nrpys: Gly
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
    Small clusters prediction:
      Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
    Single AA prediction:
      gly (Gly)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DILQLGMIWK
    Nearest Stachelhaus code(s):
      Gly DILQLGMIWK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
ctg16_452: Ala
  Search NORINE for peptide: strict or relaxed
  AMP-binding (173..577): Ala
  nrpys: Ala
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVSNMAIIYK
    Nearest Stachelhaus code(s):
      Ala DVSNMAIIYK (88% 8Å match)
    Stachelhaus code match:
      100% (strong)