LOCUS       gnlProkkaLEDIBKMG_1    14274 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LEDIBKMG_1.
ACCESSION   gnlProkkaLEDIBKMG_1
VERSION     gnlProkkaLEDIBKMG_1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-30 20:13:35
            Original ID  :: gnl|Prokka|LEDIBKMG_1
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 2130373
            Orig. end    :: 2144647
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14274
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:9274]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..9274
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..14274
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14274
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="phosphonate"
                     /region_number="2"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             complement(493..1296)
                     /locus_tag="ctg1_1668"
                     /transl_table=11
                     /translation="MATTYDGINYFPIAVNFMEENAMEVIEAKYGMKGLAIVLKLLCKI
                     YKEGYYIPWGEEQCLIFANKTGKEADAEEVQGIIEIMIEKGMIDRGSYAEHKVLTSEAI
                     QKVWIEATKRRKRNWTAMPYLLIKPKETCNEEKTVCTQNVEQDAGSDAKNACNTEQSKV
                     KQSREFPPSAPPRGKEEEVNATPVSMPGYAFNTMTHNYVGLMGNLERFGITDEKEIEAI
                     LRLSDYGRKGTPVWKLICSTNWSNIGAKGKYMIAALNRAKKRSGT"
     CDS             complement(1346..1693)
                     /locus_tag="ctg1_1669"
                     /transl_table=11
                     /translation="MKKNRKAVSKNEMMKGKWKRQIMLEKDYTEQCSEWMAERLEALIE
                     YMQYGHAAVAYMKQDGTFKLVKGTLVGYEKDFGKQYDPMEIKNTVVYRDVEQQRWMTFK
                     IENFMEWRAIV"
     CDS             complement(1834..2172)
                     /locus_tag="ctg1_1670"
                     /transl_table=11
                     /translation="MNDNLVTIEVNGKVIFAGKADLQFSLNQKVREPLRITKGKGKLME
                     ALTESFIKGGINSMENRPIEELQETIKEYLTFEYQRKGIATEPNKRSFLSELKKYARAF
                     RKKRDESE"
     CDS             2694..3218
                     /locus_tag="ctg1_1671"
                     /transl_table=11
                     /translation="MSEQQKYWFAARTRDKQEFAIRDSLEKLKTELDLNYYLPTQFVIR
                     QLKYRRKRVEVPVIKNLIFIQATKQDACDISNKYNIQLFYMKDLLTRAMLIVPDKQMQD
                     FIFVMDLDPNGVSFDNDHLSVGSRVQVVKGDFCGVEGELASEANKTYVVIRIAGVLSAS
                     VKVPKSYLRVI"
     CDS             3222..3707
                     /locus_tag="ctg1_1672"
                     /transl_table=11
                     /translation="MNTLTSQIEQLQSLAHELLYLGVDGAPIYTDHFRQLNKEVLEQSD
                     ALYPQRGATPEEEANICLALLMGYNATIYNQGDKEEKKQVVLNRCWDVLDQLPATLLKC
                     QLLTYCYGEVFEEELAKEAHTIIESWSNRELLKAEKEIAESLNNLEANPYPYSELHE"
     CDS             3704..4987
                     /locus_tag="ctg1_1673"
                     /transl_table=11
                     /translation="MIRSFLSRSPLYVLALYASVLIFLVYTCAYAYRKPFTAAIYEGEI
                     LWGFDVKILYVLSEIIGYALSKFIGVRILPSMKAGHRIYYIIGLLTFSEVALLGFALLP
                     VPLKVCSIFLSGLPLGMIWGVIFSYIEGRRISEILNVGLSVALIVSSGLVKTLGQFVMD
                     NLHVSEYWMPFTTGLLVYPVMLLCSWLLNQIPAPNEQDIIQRTKRAPMDGKDRRKFLRQ
                     FFWGICMLVVFYGALTVFRELRDSFAADIWKELHIEGAMIFTQTEVPIAAFVLVLMFLI
                     VFVRNNRLALNIIYCIAVTGGSLMVFSTLLYVYGFLSPIWWMILSGLGLYMGYIPFTYL
                     IERLIASLRVVSTAVFIIYLADSFGYLGTTGVFMVKNFVSADISWTVMLMRTALFSGFV
                     SVLSIFAIYCYFKQQLNSLILIPSEIHD"
     CDS             5001..5699
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_1674"
                     /sec_met_domain="NTP_transf_3 (E-value: 3.7e-12, bitscore:
                     44.8, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAGLGTRFGHYTELVPKGFVEVGGKPMIIRSIETLLSCGIERII
                     LGTGYKKEAYEALQADFPQIETCFSPRYADTNSMYTLYNTRDVIGDDNFLLLESDLVFE
                     RKAILSLLDDEFPDVMLVSSLTKFQDQYYVEYDRNHILTSCSVDKNALEAKGELVGIHK
                     LSNTFYRRMCADYATILESQPKLGYEYELLRMSRSVSPVRVLRVEGLKWYEIDDEADLS
                     YAEEHIIRYC"
     CDS             5719..7020
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 214.9;
                     E-value: 2.2e-65)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_1675"
                     /sec_met_domain="CTP_transf_like (E-value: 1.1e-10,
                     bitscore: 39.9, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 3.4e-120, bitscore:
                     398.4, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 1.9e-62, bitscore:
                     208.8, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKKIYVGMTADIMHPGLIHIIHEATKYGDVIVGLLTDKAIAEHK
                     RLPYLTYDQRKEVVENIKGVCEVVPQEDWSYVPNLEKLKPDYIIHGDDWKTGPLREVRE
                     QVFEVMNAQGGKVIEIPYTRGINSSSLDKDIKAIGTTPDVRLKSLRRLIQAKPVVRILE
                     AHDGLCGLIIENLEVQKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAVIIEDKVGLKKNSLFGTDAIQTQDS
                     IEGFCDKIRAGKNAQVTGDFMIIARIESLIAGKPMSDALERAYAYVQAGADGIMIHSKD
                     KSGEDIREFCRTFRKEYAHVPIVVVPTTYDHVHESELHEWGANVVIYANHLLRAAYPAM
                     MNVARTILENERAEEVRPLCMPIKEILELIPVTK"
     CDS             7032..8168
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 70.6;
                     E-value: 1.9e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_1676"
                     /sec_met_domain="TPP_enzyme_N (E-value: 6.3e-20, bitscore:
                     69.4, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.1e-18, bitscore:
                     64.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVSVEKIYDTFLHHGVDFFTGVPDSLLKNICAYITDHAPRGKHII
                     AANEGSAVGIACGYYMASGNVPLVYMQNSGLGNTVNPLLSLADEKVYSLPLLLLVGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMKIPFIILDTDEDEALAQIHDAVVSAKSRSIPHAIV
                     IRKDTFGKYKLRQEALNDYPLSREEALMQVVDHLGDNDIVVSTTGKLSRELFEYRESKG
                     QGHARDFLTVGSMGHSSSIALGIALEKPDRRVYCLDGDGAFIMHMGAVSNIGDLSPKNY
                     RHVLFNNGAHESVGGQPTLGFRLDIASIAKGCGYAHVLTASDKEGLSCALEKLSGLSGP
                     VLLEIKVRIDSRDDLGRPTTTPVENKEHFMAFLKDTHS"
     CDS             8165..9274
                     /NRPS_PKS="Domain: Aminotran_5 (30-293). E-value: 4.5e-34.
                     Score: 109.8. Matches aSDomain:
                     nrpspksdomains_ctg1_1677_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 81.8; E-value:
                     7.7e-25)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_1677"
                     /sec_met_domain="Aminotran_5 (E-value: 3e-29, bitscore:
                     100.1, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIERKILLNPGPATTTDTVKLAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGDLSKHTAVLFCGSGTINIDICLNSLLPADKKVLVVNNGAYSTRAVEVCEYY
                     GLPHIDLKFSVYELPDLSVIEKALSDNPDIALVYTTHHETGTGILNPIREIGKIAHSHG
                     AVFVVDTTSSLGMIPFDIGKDNVDFCMASAQKGLQAMTGLSFIIGDESLIRASRDYPKR
                     SYYCNLYLQYDYFEKTGEMHFTPPVQTVYAARQALDEYFAVGEEAKFARHKRVFEAIHK
                     GLQELGLQYAIKREWQSGLVVSVLYPDDPLWDFDKVHDYCYERGFTIYPGKISTTNTFR
                     LCALGEIDVEDIERFFEVMKSVNTVLVNK"
     aSDomain        8255..9043
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg1_1677_Aminotran_5.1"
                     /evalue="4.50E-34"
                     /label="ctg1_1677_Aminotran_5.1"
                     /locus_tag="ctg1_1677"
                     /protein_end="293"
                     /protein_start="30"
                     /score="109.8"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGDLSKHTAVLFCGSGTINIDICL
                     NSLLPADKKVLVVNNGAYSTRAVEVCEYYGLPHIDLKFSVYELPDLSVIEKALSDNPDI
                     ALVYTTHHETGTGILNPIREIGKIAHSHGAVFVVDTTSSLGMIPFDIGKDNVDFCMASA
                     QKGLQAMTGLSFIIGDESLIRASRDYPKRSYYCNLYLQYDYFEKTGEMHFTPPVQTVYA
                     ARQALDEYFAVGEEAKFARHKRVFEAIHKGLQELGLQYAIK"
     CDS             9287..10105
                     /locus_tag="ctg1_1678"
                     /transl_table=11
                     /translation="MLKKRLDYSQLKVIQLNILKDVDAFCRENNITYYLTYGTLLGAVR
                     HQGYIPWDDDIDIAMPRKDYEKFLSNYNLNGSKKNVYQVVAIELNNAYPYPFGKVQDLS
                     TVLLEYSDINYPLGINIDIFPIDGLPVDLKKSDKHFLKIKWLMMIMNLKKVKITIKRSF
                     LKNLILLIGKILTLLIPYRFIVCKMSYIAQRYDYEKSDYVSNLSCPDGKHERTSKRVFE
                     NSIEILFEGNNFYAPIGYHEWLHNIYGDYMKMPPVPERVSHHKFEIYKIL"
     CDS             10108..11103
                     /locus_tag="ctg1_1679"
                     /transl_table=11
                     /translation="MCSKDNFLQEVRALCIFTVILLHVPFQGHDNISFNTWLMSKQLIT
                     FPVAVFFFLSGYFYSFRNYKSRIVKLLCPFLFWNMSVHLIKFIRGESGFNIENFLLGNG
                     LPYYYLAVLLQIVLFHYIIFKYWSEMVYRVLSISISIISLMAYYYFSISYSIHFNCYLY
                     FPFWILFYTLGTFGKKYWRNLISKIPFCVILLFILISVFLMFFEANLMYYILFQEGIAG
                     SQVKFSSWVYSILIVLLLLKIDYSIDENVTRNFGTLIGDYSYGVYLIHIFILSLIYKLC
                     IVVFNDNYNVLLPFIAASITLVISVFMIYILNKCLPPFILKFLGLYVKSN"
     CDS             11087..12259
                     /locus_tag="ctg1_1680"
                     /transl_table=11
                     /translation="MLKVTDECTACGACLSICPKNCISFKSNEEGFLYPHIDIEKCVDC
                     DLCSKVCFLNDHITPTFRENDISYYAAKAIERCNLSSSGGIFPLLAESVLKNDGVVIGA
                     AWDDKFNVKHILIKSKSELPLLCGSKYIQSNTEKVFKIVKEHLSIQTVLFSGTPCQVKG
                     LKTFLGKDYDNLITVELVCHGVPSPLVFRRYLNGVLKYNNLDISQCSKINFREVKDDIY
                     RFVIYNKTKIPFYEQYTNLYTKTFLQNLFLRNSCYNCKCKLENSVGDFILGDFWGCRDF
                     YPEFYDPKGVSLVIVCTERAKKIWLNLKLSRIEVKKKIVFRSNRHLLKSASYNRNRDLF
                     FKTFIHEAEISLDDILMGYTNKDIWVKVKGLIISVLRFVGLFQLVQLYRK"
     CDS             12256..13314
                     /locus_tag="ctg1_1681"
                     /transl_table=11
                     /translation="MKIALLTLPFVNNYGGILQAYALKHFLELRGHSVCIIDRNSNFKI
                     SFIDILRLAKRKFLGNRIRNFAYFKKQYLLPMTSEIITNKEMLLLDEKYQFDIYIVGSD
                     QVWRAIYYRDIKYNFYLDFVSSKRKISFAASFGISSWEYTNTETDIIAKLLMDFSFVSV
                     REDTAVRLCSDYLNINAVQFLDPTFLLDKNEYCCLADCFYSSKKIDIFAYIMGPDSSKD
                     KLIKIISDYSGLSVQSITQSKFSFKKNESIQEWLQNFYKSKFVVTDSFHGLAFSLIFNK
                     PFIVCGFSNRGMGRYESLLRYFSLENRLLYSLEDLKELNLSTIWDINWKEVNAKIAENK
                     RFVLELMQTVGV"
ORIGIN
        1 caggaagaaa gaccgcattg tgtatttgca atgtgcacct ctgctcaatg atgattttca
       61 agtggagcaa atgtacaaca cgctggagat gatacaagac aattatgaaa agtgggtcgt
      121 ttctatggac gataccacat tgccctccaa agaagggatt cgtcacatac aagtctggca
      181 actgactgaa atactatagt ctgacaatct tttttgattg ctttgatgtc cggatgatgc
      241 cgtttacgaa gttaacatct tgttgtttac gaagttaata tcataatttt acgaagttaa
      301 aatcgtatct tcgggaagtt aacttcctga agtcacgatt ttaacttcgt attagtgctt
      361 tttgaatcgc ttttcaaccc cttgagaatc agtgtccgtt tccggaggaa aacagctgcg
      421 ttctttaatt gattgcaagc aaacagcatt ttccagaata taaaatgtac tgtttgtcag
      481 aaaagttctt ttttaggttc cgcttctttt ctttgcccgg ttcaacgctg cgatcatgta
      541 ttttcctttt gctccgatgt tactccagtt cgtgctgcaa atcagtttcc atacaggggt
      601 tccttttctc ccgtaatctg acagtcgcag gattgcttcg atctcttttt cgtctgttat
      661 tccgaatcgt tccaggtttc ccattaatcc cacgtagttg tgtgtcattg tattaaatgc
      721 gtatccgggc atactgaccg gcgtagcatt gacttcctct tccttccccc ttgggggagc
      781 tgagggggga aattctctac tttgctttac tttactttgt tcggtattgc atgcattttt
      841 tgcatcagag cctgcatcct gctctacatt ttgcgtgcag acggtctttt cttcattaca
      901 tgtctctttc ggttttatca gtagataagg catggctgtc cagttcctct ttcttcgctt
      961 ggttgcctct atccatactt tttgtattgc ttcagaggtc agtactttat gttccgcata
     1021 gcttcccctg tctatcattc ctttctcgat cattatctcg ataatcccct gcacctcttc
     1081 tgcgtctgcc tcttttcccg tcttgttggc gaaaataagg cattgttcct caccccacgg
     1141 aatataatat ccttctttat atattttgca tagaagtttc agtacaatcg cgagtccttt
     1201 catgccatat tttgcttcta ttacctccat tgcgttctct tccataaaat tcacagctat
     1261 tggaaagtaa tttattccat cgtatgttgt tgccataatt gttaagttgt tatgttgctg
     1321 attaattggt cactgaaaga ttctcctata cgatcgctct ccattccatg aaattctcta
     1381 ttttgaaggt catccacctt tgttgctcca catcccggta gaccactgtg ttttttattt
     1441 ccatcggatc atactgcttt ccgaaatctt tttcgtatcc caccaatgtt cctttcacca
     1501 gtttgaatgt tccgtcctgt ttcatataag ctacggctgc atgtccatat tgcatatatt
     1561 ctatgagggc ttccagtcgt tctgccatcc attcggagca ctgttctgtg tagtcctttt
     1621 cgagcatgat ttgtcttttc cattttcctt tcatcatttc gtttttcgat actgctttcc
     1681 tgttcttttt cataattgat tttttaaagt ttattaatga gttattgtcg ggcttttatt
     1741 tttacccatg gcaaagtacg gtaataagtt ttgaatagac taatcctgta aaagtacttt
     1801 agaaaggggc ttttacagga ttttaacaat cggttattcg ctttcatctc gctttttccg
     1861 gaatgctctg gcatattttt tcagctctga tagaaaagaa cgtttattag gctctgtagc
     1921 aatgcctttg cgctgatatt caaaggtgag atattctttt attgtttcct gtagttcttc
     1981 aatgggtctg ttttccatgc tgttgattcc gcctttgata aagctttcgg taagtgcctc
     2041 cattagcttt cctttgcctt ttgtgatgcg tagtggttct ctaacctttt gattgaggct
     2101 gaattgcaag tcggctttac ccgcaaagat tacttttcca tttacttcga tggttactaa
     2161 gttatcattc aatgagataa ctactttttt tcttccataa tgttagttat taaatgaatt
     2221 tatgaaagga caaagtttgt ataaaaaaat ataaatataa aagaataccg gagttttttt
     2281 agtttaaagg gagaatcttg aagtgtaagg atcttgttat tagttattta tcttaagata
     2341 taggcgttgt ttcaaaaaac gttcgtttga ttgaacaaag gtaaggagtc tgttttaatg
     2401 tacaaaatat ttagtggata aaattttatc aaagatttta tgttgctgat tctcaaatat
     2461 atatagagca aaaaaagttc tttgttcagc tactttacaa tattcatttt ttcatcgaaa
     2521 aaaaactcaa aaatgctgtt tcaaaagacg aacgtttttt gaaacacatt cgttcgttct
     2581 caacttctaa aaatgtttcg taaaatttga cggtttgaaa gagaaaagat gtctcgttca
     2641 aaccgcgaag cgcacccgaa ataaaggaaa atttccccaa gtataaatcg taaatgtctg
     2701 aacaacagaa gtattggttt gccgcccgta cccgagataa acaagagttt gctattcgtg
     2761 actctcttga aaaattgaag actgaacttg atctcaatta ctatcttccc actcagtttg
     2821 tcatccggca gttgaaatat cgtcgaaaac gggtggaagt ccctgttatt aagaatctta
     2881 tcttcatcca agctaccaag caagatgctt gtgatatttc taataaatac aatatccagc
     2941 ttttttatat gaaagacctg cttaccaggg ctatgctgat agttcctgat aaacagatgc
     3001 aggacttcat atttgtcatg gatttagatc cgaatggcgt cagtttcgat aatgaccatt
     3061 tatctgtcgg tagcagggtt caggtagtta aaggtgattt ctgtggtgtc gagggcgaac
     3121 ttgccagcga ggccaacaaa acttatgttg ttattcgtat tgccggtgta ttgagcgcca
     3181 gcgtcaaagt tcctaaaagt tatttacgtg tcatttaagt tatgaataca ctcacttctc
     3241 aaattgaaca attacagagt ctcgcgcacg agttactcta tttaggtgtg gatggtgctc
     3301 ctatttatac cgatcatttc cgtcagttga acaaagaagt tttagaacaa tccgatgcgt
     3361 tgtatcctca gcgtggtgct actcccgaag aggaagcaaa catctgtctg gcattattga
     3421 tgggttacaa tgcaaccatc tataatcagg gtgacaagga ggagaaaaag caagttgttc
     3481 tcaatcgttg ttgggacgtg cttgaccaac ttcctgctac tttattgaaa tgccagttgt
     3541 tgacttattg ttatggtgag gtgtttgaag aggagttggc gaaagaggcg catactatca
     3601 tagaaagttg gagcaatcga gaacttttaa aagctgaaaa agaaatagct gaaagtttga
     3661 ataatttgga agctaatcca tatccgtaca gcgaactaca cgaatgattc gttcctttct
     3721 ttcccgttct cccctttacg ttttggctct ctatgccagc gttttgattt ttctggttta
     3781 tacttgtgcc tatgcctacc gtaagccatt taccgcagcc atttatgaag gtgagattct
     3841 ttggggattc gatgtcaaaa tcctgtatgt cctttctgag attatcggct acgccctttc
     3901 caagttcatc ggtgttcgta ttctgccttc gatgaaagcg ggtcaccgca tctattatat
     3961 aatagggctg cttacttttt ccgaagttgc tttgttgggt tttgcacttc ttccggttcc
     4021 tttgaaggtg tgttctattt ttctgagcgg tcttcccctg ggtatgatct ggggtgtcat
     4081 ttttagctat atcgaaggac gtcgtatcag tgaaatattg aatgtcgggc tgagcgttgc
     4141 tttgatagtc tcttccggtt tggtgaaaac cttgggacaa ttcgtgatgg ataatttgca
     4201 tgtgtcggaa tattggatgc cttttaccac cggtttgttg gtataccctg ttatgttgct
     4261 ttgcagctgg cttctcaatc agattccggc tcccaatgag caagatatca tacagcgtac
     4321 caaacgtgct ccgatggatg gtaaagacag gcgtaaattt ttgaggcaat tcttctgggg
     4381 aatctgcatg ctggttgttt tttacggtgc cctgaccgtg ttccgtgagc ttcgtgactc
     4441 tttcgctgcc gatatttgga aggagctcca tattgagggt gcaatgatct ttactcagac
     4501 agaggttccc attgccgctt ttgtccttgt actgatgttc ctgattgtgt ttgtccgtaa
     4561 taaccgtttg gctcttaata tcatttattg cattgccgtc acaggcggtt ccttaatggt
     4621 tttttccaca ttgctttatg tgtacggttt tctttctcct atttggtgga tgattctttc
     4681 cggtcttggt ctgtatatgg ggtatattcc tttcacttac ctgatagaac gcctgattgc
     4741 ttcccttagg gtggttagta cggctgtttt tattatttat ttggccgatt ctttcggcta
     4801 tctgggcact acgggtgtgt ttatggtcaa gaacttcgtt tctgctgaca tttcctggac
     4861 tgtcatgcta atgcgtactg cccttttttc aggatttgtt tctgtcctgt cgatttttgc
     4921 gatttactgt tatttcaagc aacaattgaa ttcacttata ttaattccct ctgaaattca
     4981 tgattaaaac agcaatgatc atggctgccg gtcttggtac ccgcttcggg cattataccg
     5041 agcttgtgcc caaaggtttt gtggaggttg gtggaaaacc tatgattatc cgctctatcg
     5101 aaacccttct ttcctgcggt atcgaacgta tcatcctcgg tacgggttat aaaaaagagg
     5161 cttatgaagc ccttcaggcg gatttccccc agatagagac ctgtttcagt ccccgttatg
     5221 ccgatactaa cagtatgtac actctgtaca atacgcgtga cgtgataggc gatgacaatt
     5281 tcctgctgct tgaatcggac cttgtttttg aacgcaaggc catcctctcg ctactggatg
     5341 acgaattccc ggatgtgatg cttgtctctt ctctgaccaa gttccaggat cagtattatg
     5401 tggaatatga ccgcaatcac atccttactt cctgttcggt agacaagaac gcccttgagg
     5461 caaaaggcga gctggtcggt atccataaac tttccaatac tttctaccgc cggatgtgcg
     5521 ccgattatgc gaccatcctg gagtcccagc ctaaactggg ttacgagtac gaactgctcc
     5581 gcatgtcccg ttccgtttcc cctgtccgtg tgctcagggt ggagggtctt aaatggtatg
     5641 aaatcgatga tgaagccgac ctttcgtatg ccgaggagca catcatccgc tattgttaaa
     5701 aacaaatctt ttccatatat gaacaagaaa atctatgtcg gtatgaccgc ggatatcatg
     5761 catccggggc tgatccatat tattcatgaa gctactaaat acggtgatgt catcgtcggt
     5821 ctgctgacgg acaaggccat cgccgaacac aaacgcctcc cttaccttac ctatgatcag
     5881 cgtaaggagg ttgttgagaa tatcaagggg gtttgcgagg ttgttcccca ggaggattgg
     5941 agctatgttc cgaatctgga aaaactcaag cctgactata tcatccacgg tgacgactgg
     6001 aaaacgggtc cgttgcgcga ggtgcgcgaa caggtttttg aggtgatgaa cgcccagggg
     6061 ggcaaggtaa tcgagatccc ttatacccgg ggcatcaact cctcctcgct cgacaaggat
     6121 atcaaggcga tcgggactac ccctgacgta cgtcttaagt ccctccgccg cctgatccag
     6181 gccaagcctg tggtccgtat cctggaggct cacgacggtc tttgcggtct gattattgag
     6241 aatcttgaag tccagaaggg tgataagcgc gaggtctttg acggcatgtg gtccagcagc
     6301 ctgaccgact ccacgagtaa gggtaaaccg gatattgaag cggtcgacct taccacccgt
     6361 ttacaggacc tgaacaatat ccttgaatgt accaccaagc ctattatttt tgatggagac
     6421 acgggtggca agatcgaaca ctttgtcttt actgtgcgca ctctggaacg tcacggcatt
     6481 tctgcggtaa tcattgaaga taaagtcggt ctgaagaaga attccctttt tggtactgac
     6541 gctatccaga ctcaggatag tatcgagggt ttctgcgata agatcagagc agggaagaat
     6601 gcccaggtca ccggtgactt tatgatcatt gcgcgtatcg aaagccttat tgccggcaaa
     6661 cccatgagtg acgccctcga acgtgcttat gcctatgtac aggcgggtgc ggacggcatc
     6721 atgatccaca gcaaggataa gtcgggtgag gatatccgtg agttctgccg gactttccgc
     6781 aaagaatacg cccatgttcc cattgtcgtt gttccgacga cttatgacca tgtgcacgaa
     6841 tccgaacttc acgaatgggg tgccaacgta gtcatttacg ccaaccacct tctccgtgcc
     6901 gcttatccgg ccatgatgaa cgtggccagg accatccttg aaaacgagcg cgccgaggag
     6961 gtccgtccgc tttgtatgcc tatcaaggaa attctggaat tgattccggt cactaaataa
     7021 atcagacggt tatggtaagt gtagaaaaga tatacgatac gttccttcat cacggtgttg
     7081 acttctttac gggtgttccc gattcccttt tgaagaatat ttgcgcctat atcacggatc
     7141 atgctccgcg tggtaagcat atcatcgccg ctaatgaagg ttccgcggtg ggcattgcct
     7201 gcggttatta tatggcttct ggcaacgttc ctttggttta tatgcagaac tccggtctgg
     7261 gaaatacggt gaatcccctc ttgtcccttg cggacgagaa agtgtacagc cttcctcttc
     7321 ttttgctggt cggctggcgc ggtgagcccg gcacaaaaga cgaaccccag cataagaagc
     7381 agggcgaggt tacccttgat cttctgaaag ccatgaaaat tccttttata attctggata
     7441 cggatgaaga cgaggccctg gcgcagatcc atgacgcggt tgtctcggcg aagagccggt
     7501 cgattcccca tgcgattgtc atccgtaaag atacgtttgg aaaatataaa ttgcgtcagg
     7561 aagccttgaa tgactatcct ctgtcccgcg aggaggcgct aatgcaggtt gtcgaccacc
     7621 tcggggacaa tgacattgtg gtttccacca cgggcaagct ctcccgtgag cttttcgagt
     7681 accgtgaatc gaaagggcag gggcacgcaa gggatttcct aactgtgggt tccatgggtc
     7741 acagttcttc cattgccctg gggattgccc ttgagaagcc tgaccgccgt gtctactgtc
     7801 ttgacggtga cggtgccttt atcatgcaca tgggtgctgt cagcaatatc ggcgatcttt
     7861 ctcccaagaa ttacaggcac gtccttttca acaacggtgc gcatgaatct gtcggcggtc
     7921 aacccacgct cggtttccgt ctggatatcg cctcgatagc gaaaggttgc ggttatgcgc
     7981 atgtactgac tgcctccgac aaggaagggc tttcgtgtgc gcttgagaag ctgtccggcc
     8041 tgtccggccc ggttcttctt gaaattaagg tccggatcga ttcacgtgat gatctgggtc
     8101 gccctacgac tactccggta gagaataaag agcattttat ggcattttta aaagatacgc
     8161 attcatgaat atcgaaagaa agatcctttt gaatccgggt cccgccacca cgacggatac
     8221 ggtgaagctg gcgcaggttg ttcccgatat ctgtccgcgt gagaaagagt ttgcgggtat
     8281 gatgaaacag ttacgtgacg acctggtccg cgttgcgcat ggagaccttt ccaaacatac
     8341 ggccgtcctg ttttgcggct cgggtacgat caatatcgat atctgcctga actctcttct
     8401 tcctgcggat aagaaagttc tggtggtcaa taacggtgcc tacagcaccc gtgcggtgga
     8461 agtctgcgaa tattacggtc ttccccatat cgatttgaag ttttccgttt acgaacttcc
     8521 cgacctgtcg gtaatcgaaa aggcgctttc cgacaatccg gacatcgctt tggtctatac
     8581 cacgcaccat gaaacgggta cgggtatctt gaaccccatc cgtgagatcg gaaaaatagc
     8641 ccattcgcac ggtgccgttt ttgttgtcga caccacttcc tccctgggta tgattccttt
     8701 tgatatcgga aaggataatg ttgacttttg tatggcttcg gctcagaaag gccttcaggc
     8761 catgacgggt ctttccttta tcataggtga tgaatccctg atacgtgctt caagggatta
     8821 tccgaaacgc tcctactatt gtaacctcta tttacaatac gattactttg agaagacggg
     8881 tgagatgcat tttactcctc ctgttcaaac cgtttacgca gcccgtcagg ctcttgatga
     8941 atattttgca gtaggtgaag aggctaaatt cgcccgtcac aagagggtct ttgaagccat
     9001 ccataaaggt ttgcaagagc ttggtcttca gtatgcgatc aaacgtgaat ggcagtcggg
     9061 tcttgttgtt tctgtattgt atcctgatga tcccctctgg gattttgata aggttcatga
     9121 ttactgctat gaacgtggct ttacgatcta cccgggtaag atttccacaa cgaatacatt
     9181 ccggctttgt gcgttgggag agattgatgt ggaggatatt gagaggttct ttgaggtgat
     9241 gaaaagcgta aatacggtat tagttaataa ataatttagc tcattcatgt tgaaaaaaag
     9301 gttggactat tcccaattaa aggttataca gttgaatata ttaaaagatg tagatgcttt
     9361 ttgtcgtgaa aataatataa cttattattt aacttatggg actttgttgg gggctgtaag
     9421 acatcaagga tatattcctt gggatgacga tattgatatt gctatgccga ggaaagatta
     9481 tgaaaagttt ttatcaaatt ataatctaaa tggaagtaaa aaaaatgtgt atcaagttgt
     9541 tgctatagag ttaaataatg cttatcctta tccttttgga aaggttcaag atttatcaac
     9601 tgttttatta gaatattcag atattaatta tccgttgggg ataaatattg atattttccc
     9661 tattgatgga ttacctgtag accttaaaaa atcagacaaa cattttttga agataaagtg
     9721 gttaatgatg ataatgaatc ttaaaaaagt aaaaatcaca ataaaacgtt cttttttgaa
     9781 gaacttaata ttattaatag ggaagatttt gacacttttg attccatatc gatttatagt
     9841 gtgcaaaatg tcttatattg cacagaggta tgattatgag aaatctgatt atgtttctaa
     9901 cttgtcttgt ccagatggga aacatgaacg gacgtctaaa agagtttttg aaaatagtat
     9961 agagatttta tttgaaggta ataatttcta tgctcctata ggatatcatg aatggcttca
    10021 taatatttat ggagattata tgaaaatgcc tccagttccg gaaagagtat ctcatcataa
    10081 atttgaaatt tataagatac tgtaatcatg tgttctaagg ataattttct tcaagaagtt
    10141 cgtgcattat gtatatttac tgtaatattg ttacatgtac catttcaggg acatgataat
    10201 ataagtttta atacttggct aatgtcaaag cagttgatta ctttccctgt tgctgtgttc
    10261 ttctttttat ctggatattt ttattctttt agaaattata agagtagaat tgttaaattg
    10321 ctttgtcctt ttttattttg gaatatgagt gtacatctaa ttaagtttat tagaggggaa
    10381 agcggattta atattgaaaa ttttttatta ggtaatggat taccttatta ttatttagca
    10441 gtacttcttc agattgtgtt atttcattac ataatcttta aatattggag cgaaatggta
    10501 tatagagtat tgtccataag tattagtatt ataagtttga tggcctatta ttatttttcc
    10561 atttcttatt ctatccattt taattgttat ctctattttc ccttttggat attattctat
    10621 actttaggaa catttgggaa aaaatattgg cgtaatttaa tatctaaaat acctttttgt
    10681 gtaattctat tgtttatttt aatatctgtc tttttgatgt tttttgaagc taatttaatg
    10741 tattatattt tgtttcaaga gggaattgcc ggctctcagg ttaagttctc ttcctgggtg
    10801 tattctatac taattgtgtt gcttttactt aaaatagatt attcaataga cgaaaatgtt
    10861 actcgaaatt ttggtacact tataggtgac tattcatatg gagtctattt aattcatata
    10921 tttatattat ctttaattta taaattatgt attgtcgttt ttaatgataa ttataatgta
    10981 ttattgcctt ttatcgcagc ttctataaca ttggttattt cagtttttat gatttatatt
    11041 ttaaataaat gtcttcctcc ctttatactt aaatttttag gattgtatgt taaaagtaac
    11101 tgatgaatgt acggcttgtg gagcttgctt gtctatatgt ccaaagaact gtatttcttt
    11161 taaaagtaat gaagaaggtt ttttatatcc acatattgat atagaaaaat gtgtagattg
    11221 cgatttgtgt tctaaagttt gttttttaaa tgatcatatt actccgactt ttagggaaaa
    11281 tgatatcagt tattatgcgg ctaaggctat tgaacgatgt aatttgagct cttctggagg
    11341 aatattccca ttgcttgcag aatcagtttt gaagaatgac ggcgtagtaa taggagctgc
    11401 ttgggacgat aaatttaatg tcaaacatat tcttattaaa tcaaaaagtg aactgccatt
    11461 attatgtggt tcaaaataca tacagagtaa tacagaaaag gtcttcaaga tagttaaaga
    11521 acatctgtct attcaaactg ttcttttctc aggaacacct tgtcaagtga aaggacttaa
    11581 aacatttttg ggaaaagatt atgataattt gattacggtc gaattggttt gtcatggagt
    11641 tccttcacca ttggttttta gacggtattt gaatggggtt ttgaaatata ataatttaga
    11701 tatttcacag tgtagtaaaa ttaattttag ggaagtaaaa gatgatatct atagatttgt
    11761 gatatataat aagaccaaaa taccatttta tgaacaatat acaaatcttt atactaaaac
    11821 atttcttcaa aatttattct tacgtaattc ttgttataac tgtaaatgta aattggaaaa
    11881 ttccgtagga gattttatct taggagactt ttggggatgt agggatttct atcctgaatt
    11941 ttatgatcca aaaggagtta gcttagttat tgtttgtact gaacgtgcaa aaaaaatatg
    12001 gttaaattta aaattatcaa gaatagaagt taagaaaaag attgttttta gaagtaatag
    12061 gcatttatta aaatctgcat cttataatag aaatagagac ttgttcttta aaacttttat
    12121 tcatgaggct gagatatcac tagatgatat tttgatggga tacacaaata aggatatttg
    12181 ggttaaggtt aaaggtttga taattagtgt tttacgtttt gtggggcttt tccaattagt
    12241 tcaattgtat agaaaatgaa aatagcatta cttactttac catttgttaa taattatgga
    12301 ggaatattac aagcttatgc tttaaaacat tttttagagt taagagggca tagtgtttgc
    12361 attatagata gaaattcaaa ttttaaaata agttttattg atatattacg tcttgcaaaa
    12421 aggaagtttc tgggaaatag aattcgtaac tttgcttatt ttaagaagca atatttatta
    12481 ccaatgacat ctgagattat aactaataaa gaaatgttat tgcttgatga aaaatatcaa
    12541 tttgatattt atattgttgg tagtgaccag gtttggagag caatatatta tagagatatt
    12601 aaatataatt tttatttgga ttttgtgtcg agtaagagga agatatcctt tgccgcttct
    12661 tttggcatat cttcttggga atatacaaac actgaaactg atattattgc aaaactgtta
    12721 atggattttt cttttgtttc tgttagagaa gatacagcag taaggttatg ttctgattac
    12781 ttgaatatta atgctgtgca attcctagat ccaactttct tattggataa aaacgaatat
    12841 tgttgtcttg ctgattgttt ttatagttct aaaaagattg atatttttgc ttatataatg
    12901 gggcctgatt catctaaaga taaattaatt aaaataataa gcgattattc tggcttgagt
    12961 gttcaatcta taactcaaag taaattctct tttaaaaaga atgaaagtat tcaagaatgg
    13021 ctacaaaatt tttataagtc gaaatttgtt gtaacagact cttttcatgg tttagctttt
    13081 tctttaatat ttaataaacc ttttattgtt tgtggcttta gtaatagagg aatggggaga
    13141 tatgaatctt tattgagata tttctctttg gaaaatagac ttttatattc attggaagat
    13201 ttaaaagaac taaatttatc tactatttgg gatataaatt ggaaggaagt taatgctaaa
    13261 attgctgaga ataaaaggtt tgtattggag ttaatgcaga cggtaggtgt ataatgtcac
    13321 ttaaagaaaa tacaatttat ggtgtactgt ggagttcatt tgagaaattt ggaactttat
    13381 cgatacaatt tatttacatg attgtgatgg caagattgct atctccttct gattttggta
    13441 tagttggcat gttgacaatt tttatttctg taggccaagt tatacttgat agtggttttg
    13501 gacaggcttt aataagatta caaaaatatg atgatttaca tttttcttca atttttataa
    13561 ttaatgttat tatgggagtt ctactctatg gaatattatt ttatatggct ccatatattt
    13621 ctttattcta tagagaacct agcttaacat taatttcaag aatatctttt ttgatttttc
    13681 ccatcaattc actaagtata gtccaatata ctttattagt gaaaaaaatg gattttaaat
    13741 ctatttctaa aatatcttta ttctcgataa ttttatctac aatttcaggt attacatatg
    13801 ggtattttta ccctaatata tttgcactat taattcaaaa tgtctcattt tatttttata
    13861 ggctactttt attatggtat tatggaaact ggaaattatc atgtcgaatt tcatggagta
    13921 aattacaaga tttgatgcca ttctctttta cgttattagc tacaggcttt atttctactg
    13981 tcgtaggaga gttgtattca ttgtctattg gtaagttctt ttcttcatct gttttaggtt
    14041 tatattctca agcagaaagg ttttcgaaaa ttccatcttt ttctataaca gatgttgttc
    14101 aacgtgtgac ttatcctgca ttatcagtgt tacaagacga tgatcaaaaa ttaaagcatt
    14161 catatagaat ggttattatg tgcacattct ttatagtatt gcctgtaatg ctttttcttt
    14221 ttattagcgc tggcgaaatt tttgaattat tatttactga aaaatgggaa cagg
//
