LOCUS       gnlProkkaJBIJPFBC_18   13186 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JBIJPFBC_18.
ACCESSION   gnlProkkaJBIJPFBC_18
VERSION     gnlProkkaJBIJPFBC_18
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 03:35:14
            Original ID  :: gnl|Prokka|JBIJPFBC_18
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13186
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13186
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[93:3186]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      94..3186
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..13186
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13186
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             complement(2..103)
                     /locus_tag="ctg18_1"
                     /transl_table=11
                     /translation="MEVKEQLKLKELLFIMKQMPKTIKLIFTLERSLF"
     CDS             complement(94..3186)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155:Lantibiotic dehydratase domain protein (Score:
                     853.5; E-value: 3.3e-258)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg18_2"
                     /sec_met_domain="Lant_dehydr_N (E-value: 6.1e-126,
                     bitscore: 413.0, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 4.2e-14,
                     bitscore: 45.1, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.3e-31, bitscore:
                     102.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSLYTPTDYYMIRVPLVHQTLKNENSQDTDQLLHDLCNDSLFRE
                     QILVSSRTLYDTMNIFLQTPDKLKGKKKRNFQQAILKYATRRATRTTPFGLFSSVGIGA
                     FSDKNQLSFNQHSFYKKARVDFEWLYQLTRKLENEYIDRLSFTLNPACYIKGDRAYLLY
                     STDGKSEEVSVRATSVFHLINELCGECVAYHDIIRSLTENYENTPISKINQYVADLIDK
                     EFLISNLRPPMTVSDQFQYLIAQAESSRIPNELLQACRKIQYQIDEYNRITIGEGEDQY
                     LNLIETMNELIKTSSPLQVDTGLGDSSIQLDNETSLAISELASMFTYMAAPSAERLDHL
                     EKYKNVFLERYGYEREVPLLEMLCSNAGIGAPATYTNPVNEFFEEISFEDQFSPEMKQF
                     FMKKYFESVRKKAPIQLHDETFHRICNYEIADEEIPVSFELNFFVKLRNGRVMLYLGPN
                     VGSTRAGKTFGRFTHLSDSINAVVKKIHNKEKELTGKNKKICELSIVPNQVRSGNVTRN
                     VSYREKEMNLFTNSVLHHNDSVKAEDVLIGIDKKHIFYAKHKCTGEILSFESNHMFNPL
                     LMPNVLRFLLEISRDGKRKWNDFPWMGIYSDFKYIPEIKYKEIILSCEQWLIHKSDLSI
                     HSNSSIDEVKSAFFEFHRTYDLPQRFYIVNADNRLLIDIEDDRTLDVFFWELKKTNHNH
                     PLQLVAAELDANALKDRNQNVYSGEIVVPLIRKKPEKPLKLPVLNSVEENGSERIKMPF
                     EDWLFIKLYCKQTREEELIAFEIADIYNQISDQYPVRHFFMRYRDPKPHIRLRLNGKAE
                     VLYSLFPQLLNWLKSLREKGLVTEFVITQYEREIERYGGLDLMDAAEQVFCEDSKVVET
                     MIRMHRMKDIAISKEIAGMVSVILFLEQFELTFEEQLAFLEKNCLQNEYRTEFKKDREM
                     YIEICNSDRDWDNLRKTSDGRILYEILKTRKIAAANYACLINKAFDNKEAVYSRIGSVI
                     HLHCNRLFGTDREMENKILTLCRHSLYAQRYQKKNGSLAWK"
     CDS             complement(3400..4077)
                     /gene_functions="transport (smcogs) SMCOG1044:ABC
                     transporter, permease protein (Score: 215; E-value:
                     1.4e-65)"
                     /gene_kind="transport"
                     /locus_tag="ctg18_3"
                     /transl_table=11
                     /translation="MNVLEQLMTYYAQNGSYVMDEFGRHFLMSAYGVLFAAVVGVPAGI
                     LIAHFRRLSAWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRNTY
                     TGIISIEHAYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGTFVG
                     AGGLGDMIVRGSNATNGTAIILAGAIPTAVMAVGADLLMAWIERLLNPVKQKNRRKLIR
                     VSS"
     CDS             complement(4094..5014)
                     /locus_tag="ctg18_4"
                     /transl_table=11
                     /translation="MKRKYLKLMIGLALVATLTLSGCSLPGLSAASDQTIKIGAQSMSE
                     SEIIASMLGQLIEHHTDLKTTTIKNLGSNAVQQQALMNGEIDIAATRYTGDALTGTLRM
                     EPEKDPDKALALTQREFKKRYDLKWYDSYGFDNTYAFTVSKELADQYHLETVSDVKKWA
                     PQLKLGVDNYWMKLKGNGYQDFTKTYGMTFGGTYPMQIGLVYDAVKSGKMDIVLAYSTD
                     GRIKSYGLKMLKDDKQFFPPYDCSPVVPEKVLKEHPELEGIIKKMLGKIDTATMQELNY
                     EVDGNLKEPSVVAKEYLEKHHYFES"
     CDS             complement(5026..5679)
                     /gene_functions="transport (smcogs) SMCOG1044:ABC
                     transporter, permease protein (Score: 226.6; E-value:
                     3.9e-69)"
                     /gene_kind="transport"
                     /locus_tag="ctg18_5"
                     /transl_table=11
                     /translation="MHHIVQFLQTNGGELLYKTYEHITISLIAVILGVLVAVPLGVVLT
                     RMKKGAGTIIGIVNIIQTLPSLAILAFFIPLLGVGKVPVIVALFFYSVLPILRNTYTGI
                     RGVNKNLLESGKGIGMTPAEQVRLVELPLAAPVIMAGIRTSTIYLIGWATLASFIGGGG
                     LGDYIFIGLNLYQPEYIIGGAVPVTILAIVIDYVLAVAERKLTPAGMQRLKELS"
     CDS             complement(5696..6841)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 249.1; E-value:
                     7.2e-76)"
                     /gene_kind="transport"
                     /locus_tag="ctg18_6"
                     /transl_table=11
                     /translation="MLTLENVSKTYKGGKKAVNNVNLKIAKGEFICFIGPSGCGKTTTM
                     KMINRLIEPSAGKIFIDGENIMDQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPKLL
                     KWPEQQRKERARELLKLVDMGPEYVDRYPHELSGGQQQRIGVLRALAAEPPLILMDEPF
                     GALDPITRDSLQEEFKKLQKTLHKTIVFVTHDMDEAIKLADRIVILKAGEIVQVGTPDD
                     ILRNPADEFVEEFIGKERLIQSSSPDVERVDQIMNTQPVTITADKTLSEAIQLMRQERV
                     DSLLVVDDKHVLQGYVDVEIIDQCRKKANLIGEVLHEDIYTVLGGTLLRDTVRKILKRG
                     VKYVPVVDEDRRLIGIVTRASLVDIVYDSLWGEEKQLAALS"
     CDS             7125..7658
                     /locus_tag="ctg18_7"
                     /transl_table=11
                     /translation="MEKDPLTIIEQAEDHFIERIAENMHAFGMPSTVGRVLGIIYMNRK
                     PMTLTELSEATGMSKTRMSQVVREMLDANIAEKVFEKGVRKDLYEVEQDYYQTFITLFS
                     ATWSKVVSKNKMMHKKLNRELLSVLDEELTPEAEEKVNELLKELKEWLDYYNWLSRLIE
                     FFESEEIFKYVPKP"
     CDS             complement(7690..8364)
                     /gene_functions="transport (smcogs) SMCOG1044:ABC
                     transporter, permease protein (Score: 213.3; E-value:
                     4.5e-65)"
                     /gene_kind="transport"
                     /locus_tag="ctg18_8"
                     /transl_table=11
                     /translation="MEVLHQLGTYYSQNGGYVLQEFYRHFLMSVYGVLFAAIVGIPLGI
                     LIARYRRLSGWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRNTY
                     TGIISIEHVYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGTFVG
                     AGGLGDIIVRGSNATNGTAIILAGAIPTALMAVIADLVMGWLERALSPIKKRKKKNLAG
                     AA"
     CDS             complement(8382..9293)
                     /locus_tag="ctg18_9"
                     /transl_table=11
                     /translation="MTKIKWLGAFALVFVMLLGGCSLPGLGGASDDTIKIGAQSMTESE
                     ILANMIAQLIEHDTDLNTALVKNLGSNYVQHQAMLGGDIDISATRYSGTDLTSTLGKEA
                     EKDPKKALNIVQNEFQKRFSYKWFDSYGFDNTYAFTVTKKFAENEHINTVSDLKKNASQ
                     YKLGVDNAWLKRKGDGYKGFVSTYGFEFGTTYPMQIGLVYDAVKNGKMDAVLAYSTDGR
                     IKAYDLKILKDDKRFFPPYDCSPVIPEKVLKAHPELEGVINKLIGQIDTETMQELNYEV
                     DGKLKEPSVVAKEFLEKHHYFD"
     CDS             complement(9313..9966)
                     /gene_functions="transport (smcogs) SMCOG1044:ABC
                     transporter, permease protein (Score: 229.6; E-value:
                     4.7e-70)"
                     /gene_kind="transport"
                     /locus_tag="ctg18_10"
                     /transl_table=11
                     /translation="MNQMMTFLQTNGGELLYKTGEHLYISLIAVVLGIIVAVPLGVALT
                     RMKKGAGAVIGFVNIVQTLPSLAILAFFIPLLGVGKVPAIVALFFYSVLPILRNTYTGI
                     KGVNKNLLESGKGIGMTGWEQIRLVEIPLAIPIIMAGIRTSTIYLIGWATLASFIGGGG
                     LGDYIFIGLNLYQPEYIIGGAVPVTILAIIIDYVLAVTERKVTPKGLQGMKEVS"
     CDS             complement(9989..11131)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 248.8; E-value:
                     8.9e-76)"
                     /gene_kind="transport"
                     /locus_tag="ctg18_11"
                     /transl_table=11
                     /translation="MLKLEQVSKVYKGGKKAVNSIDLDIAKGEFICFIGPSGCGKTTTM
                     KMINRLIEPSSGRIFIDGENIMEQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPKLL
                     KWPEEKRKERARELLKLVDMGPEYLDRYPHELSGGQQQRIGVLRALAAEPPLILMDEPF
                     GALDPITRDSLQEEFKKLQRTLNKTIVFVTHDMDEAIKLADRIVILKAGEIVQVGTPDE
                     ILRNPANEFVEEFIGKERLIQSRPDIERVEQMMNRTPVTVSADKTLSQAIQLMREKRVD
                     SLLVVDRQNVLKGYVDVEMIDQNRKKASIVGDVYRSDIYTVQKGALLRDTVRKILKQGI
                     KYVPVVDEQNHLAGIVTRASLVDIVYDSIWGDEENQLMTI"
     CDS             11395..11952
                     /locus_tag="ctg18_12"
                     /transl_table=11
                     /translation="MKKTALDIIEHAEEHLIEKIAENMHTFGMPSTVGRVLGIIYMNRK
                     PMTLSELSEATGMSKTRMSQVVREMIDANIAEKVFEKGVRKDLYDVEQDYYQTFISLFA
                     ANWTKVVSKNKVLYKKLNRELSDLLQRDGLTPEAEEKVNQLLNELKEWLHYYDWLSRLI
                     EFFESEEVFRYVPKTKESSSLK"
     CDS             complement(11969..12601)
                     /locus_tag="ctg18_13"
                     /transl_table=11
                     /translation="MFSFIVHVFISLLAVSNPIGNVPIFLTLTEGYTAAERKAIARKAA
                     ILSFFILAAFLVFGHLIFKLFDINIHALRVAGGIFIFGIAYNLLNAKESHVQSLHHDEH
                     KESKEKADISVTPLSIPIIAGPGTIATVMSLSAGHSGIGHYVAVMIGIAAVIALTFLFF
                     HYSAFISSKLGKTEMNVITRLMGLILAVVAVGMIGAGLKGMFPILTS"
ORIGIN
        1 aaaacagtga tctttctaag gtgaaaatta atttgatagt cttaggcatt tgtttcatga
       61 taaacagcag ctcttttagc tttagttgtt cctttacttc catgctaaac taccattctt
      121 cttttgatat ctctgcgcat ataaagagtg cctgcaaagt gtaagtattt tgttttccat
      181 ttctctatca gttccgaata aacgattgca atgtaggtga attacactac ctatgcgtga
      241 atatactgct tctttgttat caaatgcctt gtttattaag catgcataat tagctgcagc
      301 tatttttcta gttttcaata tttcatataa tattctgcca tcacttgttt ttctgagatt
      361 atcccaatct ctatcagagt tgcatatttc aatatacatt tctctatcct tcttaaattc
      421 agtacgatac tcattctgca ggcaattttt ttctaaaaac gctaactgct cttcgaacgt
      481 aagctcgaac tgttctaaaa aaagtatgac agaaaccata cctgcgattt ccttgcttat
      541 cgcaatatcc ttcatgcgat gcattctgat catcgtttca acaaccttgc tatcttcaca
      601 gaaaacctgt tctgcagcat ccattaggtc tagcccgcca tatcgttcta tttcccgctc
      661 atattgggtg ataacaaact cagtaaccag tcctttttct cttaagcttt tcagccaatt
      721 caataattgt ggaaataaac tgtacagcac ctctgctttt ccattcaatc taagtcttat
      781 atgaggcttc ggatctcgat acctcataaa gaaatgtctg actggatatt gatcagaaat
      841 ctggttataa atatccgcta tttcaaaagc aattagctct tcttctctag tttgtttaca
      901 ataaagttta ataaacagcc aatcttcaaa tggcatttta attctttcgg atccattttc
      961 ctctactgag ttaaggaccg gtaatttcaa tggtttttct ggttttttcc tgatcagcgg
     1021 aacaacgatt tcccccgaat agacattttg gtttctatcc tttaaagcat ttgcatcaag
     1081 ctcagcagcc acaagttgta acggatggtt atgattcgtt tttttaagtt cccagaaaaa
     1141 aacatctaaa gtacgatcat cttctatatc aattaataat cgattgtctg cgttaacgat
     1201 ataaaatctt tgcggaagat cataagtacg atgaaattca aaaaatgcag atttcacctc
     1261 gtctatcgat gaattcgaat gaatgcttaa atcacttttg tgtatcagcc attgttcaca
     1321 tgataagatt atttctttat atttgatttc aggaatatac ttaaaatcac tatagatgcc
     1381 catccacggg aaatcattcc acttcctttt gccatctctt gaaatttcca ataaaaatcg
     1441 taagacattt ggcattaata aaggattaaa catatgattt gattcaaaag acagaatttc
     1501 gccagtacat ttatgtttgg cataaaagat atgtttttta tcgattccaa ttagaacatc
     1561 ttcagcttta acagaatcat tgtgatgcaa gacactgttt gtaaaaaggt tcatttcttt
     1621 ttcccgataa cttacatttc ttgttacatt tccagacctg acctgattag gcacaatact
     1681 cagctcacaa attttcttat tcttgcccgt taactctttt tccttattat gtattttttt
     1741 tacaacggca ttgattgaat cagataagtg agtaaacctt ccaaatgttt tccctgcgcg
     1801 tgtagatccg acatttggcc ctaaataaag catgactctg ccattgcgca atttaacaaa
     1861 gaaattgagt tcaaatgata ctggaatttc ttcatctgca atttcataat tgcagattct
     1921 atggaatgtt tcgtcatgta attgaatggg agctttcttt ctaactgatt caaagtattt
     1981 tttcataaaa aattgtttca tttcaggtga aaattgatcc tcaaatgata tttcttcgaa
     2041 gaattcatta acaggattcg tgtaagtagc aggggcacca atgccagcgt tggaacaaag
     2101 catttctaaa agaggaactt ctctttcata cccataacgc tccaaaaaca catttttgta
     2161 cttttctaag tggtctagtc tttctgcgga gggagcagcc atataagtaa acatactagc
     2221 caattcactt atcgcaagag atgtttcatt atctagttga atggaggagt cacctaaacc
     2281 cgtatccacc tgcagaggag atgaagtctt tatgagttcg ttcattgttt caatcagatt
     2341 taaatactgg tcctctccct ctccgatagt gatccggtta tattcatcta tttgatattg
     2401 tattttcctg caagcctgaa gaagctcatt tggaattcgg ctgctttccg cttgagcaat
     2461 taaatactga aattgatctg aaacagtcat tggcggccgt aaatttgata tcaggaactc
     2521 tttgtcaata agatctgcta cgtactgatt aattttgctt attggagtat tttcatagtt
     2581 ctctgtcaaa ctacgaataa tatcatgata agcaacacat tcaccacaaa gttcattgat
     2641 tagatggaaa accgatgttg cacgaacact aacctcttca gattttccat ctgtgctata
     2701 caacaagtaa gcacgatcac ctttgatgta acaagcggga tttaatgtaa aagaaagccg
     2761 gtcgatgtat tcgttttcta gttttctcgt caattgatag agccactcaa aatcaacacg
     2821 tgcttttttg taaaatgaat gctgattaaa agataattga tttttatcgg agaatgcccc
     2881 tatacccact gaagaaaaaa ggccaaaagg cgttgttcta gttgctcttc ttgttgcata
     2941 cttcaaaata gcttgctgga agttccgctt tttttttcct tttaatttat caggcgtttg
     3001 aaggaaaata ttcattgtgt catatagtgt cctgctagat accagtattt gttcacgaaa
     3061 taatgaatca ttacaaaggt catgcaataa ctgatctgta tcctgagagt tctcattttt
     3121 caaggtctga tgtaccaaag gaacccgaat catataataa tctgtaggtg tatataagga
     3181 tttcatctta gtctttaacc tcccatattt atccacttca ataacaacaa gaattcaaca
     3241 tcccttcgta aagtcctcca ttttattcat tccattctaa aattttcata atattctatt
     3301 taaactatac atttgaaaaa tcaaaaaaaa atcaagattc acccaataaa tcccataaaa
     3361 aaaggactct tttccctttt agaaaagaat cctttttgct taactcgata cacgaattaa
     3421 ctttcttcta tttttttgtt taactgggtt caacaatctt tcaatccagg ccatgagcaa
     3481 atccgcccct accgccatca ccgcagttgg tatcgctccg gctagaataa tcgcagttcc
     3541 gtttgtcgcg tttgagccgc ggacgatcat gtccccaagg cctccggcac cgacaaatgt
     3601 gccgatcgct gtaattccga tggcaatgac gagagccgtg cgaaggcccg ccataatgac
     3661 agaaagtgcg agcgggagct caaccattct gagcacttgg aatttcgtca tgcccattgc
     3721 ttttcccgat tctaagtagg catgctcaat actgataatg cctgtgtacg tgtttcgaat
     3781 aatcggcagc agggaataca gaaataatga tagaatcacg gtatttgcgc cgagccccat
     3841 aacaagcatt aagacggcca gcatagcgag cgccgggatt gtttgaataa cgtttgttac
     3901 ggcaaacacc caggctgaca aacggcgaaa atgcgcgatg aggattccgg ccggaacccc
     3961 gacgacagcg gcaaataaaa cgccgtaagc cgacatgaga aagtggcggc cgaattcatc
     4021 catgacgtaa ctgccattct gcgcgtaata cgtcattaac tgttcaagca cgttcattga
     4081 cctcttcccc ctttcacgat tcgaagtagt gatgtttttc taaatattcc ttggcaacga
     4141 cagacggttc tttgagattg ccgtcgactt catagttaag ctcctgcatc gtggctgtgt
     4201 cgatttttcc gagcattttc ttgatgatgc cttcaagctc aggatgttct ttgagcacct
     4261 tttccggaac aaccggagaa cagtcgtacg gcgggaaaaa ttgtttatca tcctttagca
     4321 ttttgagacc ataggacttg attcttccat cggttgaata cgcaagcaca atgtccattt
     4381 ttccgctttt caccgcgtcg tacacaaggc cgatctgcat cggatacgtg ccgccgaatg
     4441 tcatgccgta ggttttcgta aaatcctgat agccgtttcc tttgagcttc atccaatagt
     4501 tatcaacgcc cagctttaat tgcggcgccc attttttaac gtctgatacg gtctctaaat
     4561 ggtattggtc ggccaactcc ttgctgactg taaaggcata tgtattatca aacccgtagg
     4621 agtcatacca ctttaaatca tatctttttt taaactcccg ctgagtaagc gccagcgctt
     4681 tgtccggatc tttttcaggt tccattctca gcgtgcctgt cagcgcgtct cccgtatatc
     4741 ttgtggcggc aatgtcgatt tccccgttca ttaaagcctg ctgctgcacc gcgttggagc
     4801 caagattttt aatcgttgtt gttttgagat ctgtatggtg ttcgatcaac tgaccaagca
     4861 tgctggcgat gatttctgat tcgctcatgc tttgcgcgcc gattttaatg gtctggtctg
     4921 aagcagcgct gagaccagga agcgaacatc cgctcagcgt cagcgttgcc acaagtgcta
     4981 aacctatcat taatttgaga tattttcttt tcatgagccg cctccttatg acaattcctt
     5041 caatctctgc atgccggcag gtgtcagttt tcgttcagca actgccagca cataatcaat
     5101 cacaattgcc aatatcgtga caggtaccgc gcccccgatg atatattccg gctgatacaa
     5161 attcagtccg ataaaaatgt aatcacccaa tccgccgcct ccgataaagg aagcaagcgt
     5221 ggcccagccg attaagtaaa tcgtcgatgt tctgattccc gccatgatca ctggcgcggc
     5281 aagcggcagc tccaccaagc ggacttgttc agccggcgtc attccgattc ctttaccaga
     5341 ctcgagcaga tttttgttga cgccgcgaat gccggtatac gtgttgcgaa gaatcggcaa
     5401 tacggaatag aaaaacaaag ccacaatgac cggaaccttc cctacaccaa ggagcgggat
     5461 aaaaaaagcg aggatggcca gactcggcag cgtctgaata atattgacaa tgccgataat
     5521 ggtgccggct ccttttttca ttctggtaag tacaactccg agggggacgg caaccagcac
     5581 gcccaggatc acagcaatga gcgatatcgt aatatgctcg tatgttttat aaagaagctc
     5641 gcccccattg gtttgcaaaa attgaacaat atgatgcatg acttatcgct cctccctatg
     5701 acaatgctgc gagctgcttt tcttctcccc agagggagtc atacacgatg tcgaccagac
     5761 ttgccctcgt cacaattccg atcaggcgtc ggtcttcatc cacaacggga acatatttga
     5821 caccccgttt taaaattttg cggaccgtgt cgcgcagcag tgtgccgccc agtactgtgt
     5881 atatatcttc atgtaaaacc tcacctatga gattggcctt tttccggcat tgatcaatga
     5941 tttcaacatc gacatagcct tgcagaacgt gcttgtcatc gacgaccagc aatgaatcga
     6001 cccgttcctg cctcatcagc tgaatggcct cagaaagcgt tttatccgcg gtgatcgtta
     6061 caggctgtgt gttcataatc tggtcaaccc gttcaacatc cgggctggat gactgaatca
     6121 gccgctcctt gccgataaat tcctcaacaa attcgtctgc cggatttctt aaaatgtcat
     6181 cgggcgttcc aacttgaacg atttctcccg cttttaaaat cacaatccgg tctgccagct
     6241 taatcgcttc atccatatcg tgggtaacaa atacgatggt tttatgtaag gttttttgca
     6301 gttttttaaa ttcttcctgg agggaatccc tcgtaatcgg gtcgagtgcc ccaaacggtt
     6361 catccattaa gataagcggc ggctccgcgg caagtgcccg taatacacca attcgctgct
     6421 gctgtccccc gcttaattca tgagggtaac ggtctacata ttctggcccc atatcgacca
     6481 attttaaaag ctcacgcgcc cgctctttcc gctgctgctc cggccatttc agcagttttg
     6541 ggacgagtga gatattctgc tgaatggtca tatggggaaa caggccgatc tgctgaatca
     6601 catagccaat tttgcgcctg agctctacag gatcctggtc catgatgttt tcgccgtcaa
     6661 tgaaaatctt cccggcggaa ggctcaatta atcggttaat cattttcatt gttgtcgttt
     6721 ttccgcagcc gctcggtccg ataaagcaga taaattcgcc ttttgcaatc ttaagattta
     6781 cgttgttcac ggcttttttg ccgcccttgt atgttttcga gacattttct aatgtcagca
     6841 aacatcgcac ctccaaaatt aagtttattc aatttgttca gtttaaattt aatttttcag
     6901 acaattgaat gcttcccatt atagaataaa gtttataaaa taaaaagttt acaatttgtt
     6961 catattattt ataaagtatg tgtaaacgct gatttacccg cattgacgtg tgttgatctc
     7021 cttattgctc caatttcctg ccaaattctc ttttgacagc attttcgccg tatcaaaaat
     7081 gtggtatatt gacatcggaa ttgttagctg aaaggatgaa accgttggag aaagatccgt
     7141 taacgatcat tgaacaagcc gaggaccatt ttatagaaag aatcgcggaa aacatgcatg
     7201 catttggaat gccctctacc gtcggacgag tgctgggcat tatttatatg aatcgaaaac
     7261 cgatgacgct tacggaatta tctgaggcca ccggcatgag caaaacacgc atgagccagg
     7321 tagtgcggga aatgcttgat gccaacattg ccgagaaggt gttcgaaaaa ggcgtgcgaa
     7381 aagatttata tgaggttgag caggactact atcaaacatt tatcacgctg ttttcagcca
     7441 cctggagcaa agtcgtcagc aaaaacaaaa tgatgcataa aaaactcaat cgggagctgc
     7501 ttagcgtgtt ggatgaagag cttactcctg aagcggaaga aaaagtgaat gaactgctga
     7561 aagaattaaa ggaatggctt gattattata attggctcag ccgtttgatt gagttttttg
     7621 agagcgaaga aatttttaaa tatgtgccga agccgtaaaa aacgccctgt cattacaagg
     7681 cgttttttct tatgcggcac ctgccaagtt tttcttcttt ctctttttaa tcgggcttaa
     7741 tgctcgttca agccagccca tgaccaaatc ggcaatcacc gccatcagag ctgtggggat
     7801 cgctcccgct aatataatcg cggttccgtt tgtggcgttt gatcctctga cgatgatgtc
     7861 cccgagaccg ccagcaccga caaatgtccc gatggccgta atgccgatgg caatgacaag
     7921 cgcggtgcgc aggccggcca ttatgacaga aagcgcaagc ggaagctcga ccatccgcag
     7981 cacttgaaat tttgtcatcc ccattgcttt tccggattca agatagacgt gctcaatact
     8041 gataatccca gtatacgtat ttctgataat cggcagaaga gaatacagaa ataatgacaa
     8101 tatcaccgta ttagcgccca gccccatgac aagcatcagc acggcgagca tggcgagagc
     8161 cggaatggtc tgaatgacgt tcgtgaccgc aaaaacccat ccgcttaatc ttctgtatct
     8221 ggctatcagg atgccgagcg gaattccaac aatggcggca aataaaacgc cgtacaccga
     8281 catcagaaaa tggcggtaaa attcctgcag cacgtaaccg ccgttttgcg aatagtatgt
     8341 gccaagctgg tgtagtactt ccatatgatc cacctctttt cttagtcaaa ataatgatgt
     8401 ttctctaaaa attcctttgc tacgacagac ggctccttca gcttgccatc cacctcataa
     8461 ttaagttcct gcatcgtttc cgtgtcgatt tgcccaatca gcttattgat cacaccttca
     8521 agctccggat gcgccttaag caccttttcc ggaatcaccg gtgaacagtc atacggcggg
     8581 aagaaacgct tatcatcttt taagattttc aagtcatagg ctttaatccg tccatccgtt
     8641 gaataagcca gaacggcgtc cattttcccg tttttgactg cgtcatagac aagcccgatc
     8701 tgcattggat aagttgtgcc gaattcaaag ccatatgtgc tgacaaagcc tttatacccg
     8761 tcgccttttc gtttcagcca agcattgtcg acgcctaatt tatattggga ggcatttttt
     8821 ttcaggtcgg acacggtgtt aatatgctca ttttccgcaa acttttttgt tacggtgaag
     8881 gcatacgtgt tatcaaagcc gtaggaatca aaccatttat aagaaaagcg cttttgaaac
     8941 tcgttctgca caatgttcag cgcttttttt ggatctttct ccgcttcctt gccgagggtg
     9001 cttgttaaat ctgttccgga atagcgcgtg gctgaaatat caatgtcacc gcccagcatc
     9061 gcttggtgct gaacatagtt tgagccgagg tttttcacta aagcggtatt caaatctgta
     9121 tcatgttcaa taagctgcgc gatcatattc gctaaaattt ctgattctgt catgctttgc
     9181 gccccgattt tgatcgtgtc gtcagaagcg ccgccgagac ccggcagaga gcagccgcct
     9241 agcagcatga caaagacgag agcaaacgcg ccaagccatt tgatttttgt cattttcaac
     9301 agagccaact ccttacgaaa cttccttcat cccttgcaag cctttcggcg tcacctttcg
     9361 ttctgtcaca gccagcacat aatcaataat aattgccaga attgtgacag gcacggcacc
     9421 gccaatgata tattcaggct ggtataggtt cagtccgata aaaatatagt ccccgaggcc
     9481 gcctcccccg ataaacgacg caagtgtcgc ccagccaatt agatagatcg ttgatgtgcg
     9541 gatccccgcc atgatgatgg gaatcgccag cgggatttca acgagccgaa tctgctccca
     9601 gccggtcatg ccaatccctt tccccgattc caggaggttt ttatttacac ctttaatgcc
     9661 ggtatacgta ttgcgcagga tcggcagcac cgaatagaaa aataaagcga caatcgcagg
     9721 cacttttcct acgccgagaa gcggaataaa aaaggctaaa atcgccagac tcggcagggt
     9781 ttgcacaatg tttacgaaac cgattaccgc acctgcgcct tttttcattc tggtaagagc
     9841 aacgccgagc ggcactgcaa cgataatgcc caatacaacg gctatgagtg aaatatataa
     9901 atgctctcct gttttataca acagctctcc gccgttcgtt tgcaaaaaag tcatcatttg
     9961 attcatctta aaagagctcc tcccctggtc agatcgtcat gagctggttt tcctcgtcgc
    10021 cccaaatgga atcgtatacg atatcaacga ggctcgctct tgtcacaatc cctgctaaat
    10081 ggttctgttc atcgaccacc ggaacatact tgatcccctg cttcaaaatt tttcggactg
    10141 tatcgcgaag aagcgcccct ttttgaacgg tatatatatc tgaacggtat acgtcgccaa
    10201 cgatgctcgc ttttttgcgg ttttgatcaa tcatttccac atcaacatag cccttcagca
    10261 cgttttgccg gtccacaacg agcagcgagt caacacgttt ttctctcatc agctgaatcg
    10321 cctgagaaag cgttttgtcc gcagataccg tcaccggcgt tctgttcatc atttgctcta
    10381 cccgctcgat atccggtctt gactgaatca ggcgctcttt cccgataaat tcttcaacaa
    10441 actcatttgc cgggtttcga agaatctcat caggtgtgcc gacttgaacg atttctcccg
    10501 cttttaatat cacaatcctg tcagcaagct taatcgcttc atccatatcg tgggttacaa
    10561 acacaatcgt tttgtttaag gttctctgca gttttttgaa ttcttcctga agggaatcac
    10621 gcgtaatcgg atcaagcgct ccgaacggtt catccattaa aatgagaggg ggttccgctg
    10681 ccagggcgcg cagcacgccg attctctgct gctgtccgcc gctgagctca tgcggataac
    10741 ggtctaaata ctctgggccc atatccacaa gctttaacag ctcgcgcgcc cgttctttcc
    10801 gtttttcctc aggccatttc agcagctttg gtacgagtga gatgttctgc tggatggtca
    10861 tatgggggaa caaaccaatc tgctgaatca catagccgat ttttctcctc agctcaaccg
    10921 ggtcctgttc cataatattt tctccgtcga taaaaatcct tccagacgat ggttctatca
    10981 gtctgttgat catcttcatc gtcgtcgttt ttccacagcc gctcgggccg ataaaacaga
    11041 taaattcacc tttggcaata tctaaatcaa tgctgttcac agcttttttg ccgcctttat
    11101 atacttttga cacttgttcc aatttcagca atccgtgcac ctccgcaggt ttcctttaaa
    11161 ttttctgaaa agtataatcc ttattatagt ttgaactttg taaaataaaa agtttacaat
    11221 gtgttgaaat tatatgttat ttatagatta tttattgtta tgaccgagac ggaaagggtg
    11281 ttcttacaat tacgccggat acctcccact tcctcagcat tcagctattt tcaacaccag
    11341 gaagaaatat gatatattga caccatcaat tgccatttga agggatgatc agctgtgaaa
    11401 aaaaccgctc tcgacatcat tgaacatgct gaagagcatc tcattgagaa gattgccgaa
    11461 aatatgcata cgtttggaat gccttcaact gtcggacgtg tgctcggaat tatttatatg
    11521 aatcgaaaac caatgacctt aagcgagctc tctgaggcaa cgggcatgag caaaacacgg
    11581 atgagccagg ttgtccggga aatgatcgat gccaatatcg ccgaaaaggt gtttgaaaaa
    11641 ggcgtacgaa aagaccttta tgacgtcgag caggattatt atcaaacctt catttcttta
    11701 tttgcggcga attggacaaa ggtcgtgagc aaaaacaaag tgctgtataa aaaattaaac
    11761 cgggagctga gtgatctttt acaaagggac gggcttaccc cggaagcgga agagaaagtc
    11821 aatcagctgc tgaatgaatt aaaagaatgg cttcattact atgattggct gagcaggttg
    11881 attgaatttt ttgagagtga ggaagtcttt cggtacgtgc caaaaacaaa agaaagcagc
    11941 tctctaaaat aaggagctgc tttttgcatc atgaggttaa gatcggaaac atgcctttca
    12001 gccccgcacc aatcatcccg accgcaacca cggctaagat taatcccatc aatctggtaa
    12061 tcacattcat ctcagttttt ccgagtttgc tgctgataaa agcagaatag tggaaaaaga
    12121 gaaaggtcag ggcaataacg gcggctatgc cgatcatgac agccacataa tgaccaatgc
    12181 cgctatgtcc ggcggaaagg ctcatcactg ttgcaatcgt tccgggccca gcaatgatcg
    12241 gaatggataa aggtgtgact gatatatccg ctttttcctt gctttcctta tgttcatcat
    12301 ggtgaagaga ttgcacgtgc gattctttcg cattcaatag attataggca atgccgaaaa
    12361 tgaatatgcc gcccgccact cggagcgcgt gaatgttgat atcaaacagt ttaaagataa
    12421 gatgaccgaa aaccaaaaaa gctgcgagaa taaaaaagga taaaatagct gccttccggg
    12481 caatcgcttt tctttccgct gcagtatagc cttctgtcag cgtcagaaat atcggtacgt
    12541 ttccgatcgg attcgatact gcgagtaaag aaatgaagac gtgaacgata aatgagaaca
    12601 tcatatacct ccttgttgat agtctctgca caggaaatag aattattctc caccctttta
    12661 cccggaggcg atttcccggt aaacctttat agcctgtcag aaacgcgcca tgctacaatg
    12721 aagtgacaaa ttgaatagga aggacgtata cagatgttca aaaaaattgc ggcagatgcc
    12781 ttgggcttat ctgatatcgg aaaaattatc gaacctcagg actatgacaa aacagacgca
    12841 gatgactatg tcatgcatga agataatgag aaaatttatt tcttgattaa aacaaaagca
    12901 gacgagtatt gctttacgaa cctggccctg atccatgtag acggcgaacg cgccacttcc
    12961 tcgaaacgaa cgttgaaacg ctatccttat tcgcaatata aaatctctga cgtttttctt
    13021 gaaactgccg gaaaagtgga tttggatgtt gaaattaagt tcaagctggg cggtgaacaa
    13081 ttcgacattg atgtccacaa agaccagatt gaaaagttaa aagaccttta taaagcactg
    13141 cttcgcatcg ctgaaacaac ctatgaaaat gacattttaa tcaatc
//
