LOCUS gnlProkkaEMPJECPA_15 25245 bp DNA linear UNK 01-JAN-1980 DEFINITION gnl|Prokka|EMPJECPA_15. ACCESSION gnlProkkaEMPJECPA_15 VERSION gnlProkkaEMPJECPA_15 KEYWORDS . SOURCE ORGANISM . COMMENT ##antiSMASH-Data-START## Version :: 7.1.0 Run date :: 2025-04-28 03:18:14 Original ID :: gnl|Prokka|EMPJECPA_15 NOTE: This is a single region extracted from a larger record! Orig. start :: 0 Orig. end :: 25245 ##antiSMASH-Data-END## FEATURES Location/Qualifiers protocluster 1..25245 /aStool="rule-based-clusters" /category="NRPS" /contig_edge="True" /core_location="[1417:5245]" /cutoff="20000" /detection_rule="cds(Condensation and (AMP-binding or A-OX))" /neighbourhood="20000" /product="NRPS" /protocluster_number="1" /tool="antismash" proto_core 1418..5245 /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="cds(Condensation and (AMP-binding or A-OX))" /neighbourhood="20000" /product="NRPS" /protocluster_number="1" cand_cluster 1..25245 /SMILES="NC(CC(C)C)C(=O)O" /candidate_cluster_number="1" /contig_edge="True" /detection_rules="cds(Condensation and (AMP-binding or A-OX))" /kind="single" /product="NRPS" /protoclusters="1" /tool="antismash" region 1..25245 /candidate_cluster_numbers="1" /contig_edge="True" /product="NRPS" /region_number="1" /rules="cds(Condensation and (AMP-binding or A-OX))" /tool="antismash" aSDomain 65..889 /aSDomain="Epimerization" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg15_1_Epimerization.1" /evalue="2.30E-138" /label="ctg15_1_Epimerization.1" /locus_tag="ctg15_1" /protein_end="275" /protein_start="0" /score="454.0" /tool="antismash" /translation="MLHAAKGFDPERVEKTLQALIEHHDALRMVYREENGDIVQAYKPI GESKVSFEIVDLYGSDEEMLRSQIKILANKLQSSLDLRTGPLLKAEQYRTEAGDHLLIA VHHLVVDGVSWRILLEDFASGYMQAEKEESLVFPQKTNSFKDWAEELAAFSQSAHLLQQ AEYWSQIAAEQVSPLPKDCETEQRIVKDTSSVLCELTEEDTKHLLTDVHQPYGTEINDI LLSALGLTMKEWTKGAKIGINLEGHGREDIIPNVNISRTVGWFTAQYPVVLDI" aSModule 65..1348 /domains="nrpspksdomains_ctg15_1_Epimerization.1" /domains="nrpspksdomains_ctg15_1_TIGR01720.1" /incomplete /locus_tags="ctg15_1" /tool="antismash" /type="unknown" CDS 65..1381 /NRPS_PKS="Domain: Epimerization (0-275). E-value: 2.3e-138. Score: 454.0. Matches aSDomain: nrpspksdomains_ctg15_1_Epimerization.1" /NRPS_PKS="Domain: TIGR01720 (279-428). E-value: 5.7e-55. Score: 177.3. Matches aSDomain: nrpspksdomains_ctg15_1_TIGR01720.1" /gene_functions="biosynthetic-additional (rule-based-clusters) Condensation" /gene_functions="biosynthetic-additional (smcogs) SMCOG1127:condensation domain-containing protein (Score: 126.1; E-value: 3.4e-38)" /gene_kind="biosynthetic-additional" /locus_tag="ctg15_1" /sec_met_domain="Condensation (E-value: 8.8e-74, bitscore: 241.1, seeds: 42, tool: rule-based-clusters)" /transl_table=11 /translation="MLHAAKGFDPERVEKTLQALIEHHDALRMVYREENGDIVQAYKPI GESKVSFEIVDLYGSDEEMLRSQIKILANKLQSSLDLRTGPLLKAEQYRTEAGDHLLIA VHHLVVDGVSWRILLEDFASGYMQAEKEESLVFPQKTNSFKDWAEELAAFSQSAHLLQQ AEYWSQIAAEQVSPLPKDCETEQRIVKDTSSVLCELTEEDTKHLLTDVHQPYGTEINDI LLSALGLTMKEWTKGAKIGINLEGHGREDIIPNVNISRTVGWFTAQYPVVLDISDADAS AVIKTVKENLRRIPDKGVGYGILRYFTETAETKGFTPEISFNYLGQFDSEVKTDFFEPS AFDMGRQVSGESEALYALSFSGMIRNGQFVLSCSYNEKEFERATVEEQMERFKENLLML IRHCTEKEDKEFTPSDFSAEDLEMDEMGDIFDMLEENLK" CDS_motif 86..160 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg15_1_0001" /evalue="1.50E-06" /label="C2_LCL_024-062" /locus_tag="ctg15_1" /protein_end="32" /protein_start="7" /score="20.6" /tool="antismash" /translation="FDPERVEKTLQALIEHHDALRMVYR" CDS_motif 365..430 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg15_1_0002" /evalue="2.70E-12" /label="NRPS-E2" /locus_tag="ctg15_1" /protein_end="122" /protein_start="100" /score="38.7" /tool="antismash" /translation="LLIAVHHLVVDGVSWRILLEDF" CDS_motif 833..883 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg15_1_0003" /evalue="1.00E-08" /label="NRPS-E5" /locus_tag="ctg15_1" /protein_end="273" /protein_start="256" /score="27.1" /tool="antismash" /translation="NISRTVGWFTAQYPVVL" aSDomain 902..1348 /aSDomain="TIGR01720" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg15_1_TIGR01720.1" /evalue="5.70E-55" /label="ctg15_1_TIGR01720.1" /locus_tag="ctg15_1" /protein_end="428" /protein_start="279" /score="177.3" /tool="antismash" /translation="ASAVIKTVKENLRRIPDKGVGYGILRYFTETAETKGFTPEISFNY LGQFDSEVKTDFFEPSAFDMGRQVSGESEALYALSFSGMIRNGQFVLSCSYNEKEFERA TVEEQMERFKENLLMLIRHCTEKEDKEFTPSDFSAEDLEMDEMGD" CDS_motif 923..982 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg15_1_0004" /evalue="6.30E-12" /label="NRPS-E6" /locus_tag="ctg15_1" /protein_end="306" /protein_start="286" /score="37.5" /tool="antismash" /translation="VKENLRRIPDKGVGYGILRY" CDS_motif 1016..1045 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg15_1_0005" /evalue="1.10E-03" /label="NRPS-E7" /locus_tag="ctg15_1" /protein_end="327" /protein_start="317" /score="11.3" /tool="antismash" /translation="PEISFNYLGQ" aSDomain 1418..1513 /aSDomain="NRPS-COM_Nterm" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg15_2_NRPS-COM_Nterm.1" /evalue="1.40E-16" /label="ctg15_2_NRPS-COM_Nterm.1" /locus_tag="ctg15_2" /protein_end="32" /protein_start="0" /score="51.3" /tool="antismash" /translation="MSQFSKDQVQDMYYLSPMQEGMLFHAILNPGQ" CDS 1418..5245 /NRPS_PKS="Domain: NRPS-COM_Nterm (0-32). E-value: 1.4e-16. Score: 51.3. Matches aSDomain: nrpspksdomains_ctg15_2_NRPS-COM_Nterm.1" /NRPS_PKS="Domain: Condensation_DCL (9-308). E-value: 5.8e-119. Score: 388.5. Matches aSDomain: nrpspksdomains_ctg15_2_Condensation_DCL.1" /NRPS_PKS="Domain: AMP-binding (469-867). E-value: 2.1e-111. Score: 364.3. Matches aSDomain: nrpspksdomains_ctg15_2_AMP-binding.1" /NRPS_PKS="Domain: PCP (973-1042). E-value: 1.3e-25. Score: 81.3. Matches aSDomain: nrpspksdomains_ctg15_2_PCP.1" /NRPS_PKS="Domain: Thioesterase (1060-1255). E-value: 5.2e-37. Score: 120.3. Matches aSDomain: nrpspksdomains_ctg15_2_Thioesterase.1" /gene_functions="biosynthetic (rule-based-clusters) NRPS: Condensation" /gene_functions="biosynthetic (rule-based-clusters) NRPS: AMP-binding" /gene_functions="biosynthetic-additional (rule-based-clusters) PP-binding" /gene_functions="biosynthetic-additional (smcogs) SMCOG1127:condensation domain-containing protein (Score: 335.6; E-value: 9.4e-102)" /gene_kind="biosynthetic" /locus_tag="ctg15_2" /sec_met_domain="Condensation (E-value: 1e-93, bitscore: 306.6, seeds: 42, tool: rule-based-clusters)" /sec_met_domain="AMP-binding (E-value: 1.8e-121, bitscore: 398.4, seeds: 400, tool: rule-based-clusters)" /sec_met_domain="PP-binding (E-value: 4.6e-18, bitscore: 58.5, seeds: 164, tool: rule-based-clusters)" /transl_table=11 /translation="MSQFSKDQVQDMYYLSPMQEGMLFHAILNPGQSFYLEQITMKVKG SLNIKCLEESMNVIMDRYDVFRTVFIHEKVKRPVQVVLKKRQFHIEEIDLTHLTGSEQT AKINEYKEQDKIRGFDLTRDIPMRAAIFKKAEESFEWVWSYHHIILDGWCFGIVVQDLF KVYNALREQKPYSLPPVKPYKDYIKWLEKQDKQASLRYWREYLEDFEGQTTFAEQRKKQ KDGYEPKELLFSLPEAETKAFTELAKSQHTTLSTALQAVWSVLISRYQQSGDLAFGTVV SGRPAEIKGVEHMVGLFINVVPRRVKLSEGITFNGLLKQLQEQLLQSEPHQYVPLYDIQ SQADQPKLIDHIIVFENYPLQDAKNEESSENGFDMVDVHVFEKSNYDLNLMASPGDEML IKLAYNENVFDEAFILRLKSQLLTAIQQLIQNPDQPVSTINLVDDREREFLLTGLNPPA QAHETKPLTDWFKEAVNVNPDAPALTYSGQTLSYRELDEEANRLARRLQKHGAGKGSVV ALYTKRSLELVIGILGVLKAGAAYLPVDPKLPEDRISYMLADSAAACLLTHQEIKEQVA ELPYTGTTLFIDDQTRFEEQASDPATAIDPNDPAYIMYTSGTTGKPKGNITTHANIQGL VKHVDYMAFSDQDTFLSVSNYAFDAFTFDFYASMLNAARLIIADEHTLLDTERLTDLIL QENVNVMFATTALFNLLTDAGEDWMKGLRCVLFGGERASVPHVRKALRVMGPGKLINCY GPTEGTVFATAHVVHDLPDSISSLPIGKPISNASVYILNEQSQLQPFGAIGELCISGMG VSKGYVNRADLTKEKFINNPFKPGETLYRTGDLARWLPDGTIEYAGRIDDQVKIRGHRI ELEEIEKQLQEYPGVKDAVVVADRPESGDASINAYLVNRTQLSAEDVKAHLKKQLPAYM VPQTFTFLDEIPLTTNGKVNKRLLPKPDQDQLAEEWIGPRNEMEETIAQIWSEVLGRKQ IGIHDDFFALGGHSLKAMTAASRIKKELGIDLPVKLLFEAPTIAGISAYLKNGGPDRLQ DVTIMNQDQEQIIFAFPPVLGYGLMYQNLSSRLPSYKLCAFDFIEEEDRLDRYADLIQK LQPEGPLTLFGYSAGCSLAFEAAKKLEEQGRIVQRIIMVDSYKKQGVSDLDGRTVESDV EALMNVNRDNEALNSEAVKQGLKQKTHAFYSYYVNLISTGQVKADIDLLTSGADFDMPE WLASWEEATTGVYRVKRGFGTHAEMLQGETLDRNAGILLEFLNTQTVTVS" aSDomain 1445..2341 /aSDomain="Condensation" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg15_2_Condensation_DCL.1" /domain_subtypes="Condensation_DCL" /evalue="5.80E-119" /label="ctg15_2_Condensation_DCL.1" /locus_tag="ctg15_2" /protein_end="308" /protein_start="9" /score="388.5" /tool="antismash" /translation="QDMYYLSPMQEGMLFHAILNPGQSFYLEQITMKVKGSLNIKCLEE SMNVIMDRYDVFRTVFIHEKVKRPVQVVLKKRQFHIEEIDLTHLTGSEQTAKINEYKEQ DKIRGFDLTRDIPMRAAIFKKAEESFEWVWSYHHIILDGWCFGIVVQDLFKVYNALREQ KPYSLPPVKPYKDYIKWLEKQDKQASLRYWREYLEDFEGQTTFAEQRKKQKDGYEPKEL LFSLPEAETKAFTELAKSQHTTLSTALQAVWSVLISRYQQSGDLAFGTVVSGRPAEIKG VEHMVGLFINVVPRRVKL" aSModule 1445..5182 /complete /domains="nrpspksdomains_ctg15_2_Condensation_DCL.1" /domains="nrpspksdomains_ctg15_2_AMP-binding.1" /domains="nrpspksdomains_ctg15_2_PCP.1" /domains="nrpspksdomains_ctg15_2_Thioesterase.1" /final_module /locus_tags="ctg15_2" /monomer_pairings="Leu -> Leu" /tool="antismash" /type="nrps" CDS_motif 1454..1495 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg15_2_0001" /evalue="3.00E-05" /label="C1_DCL_004-017" /locus_tag="ctg15_2" /protein_end="26" /protein_start="12" /score="15.8" /tool="antismash" /translation="YYLSPMQEGMLFHA" CDS_motif 1517..1633 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg15_2_0002" /evalue="2.50E-12" /label="C2_DCL_024-062" /locus_tag="ctg15_2" /protein_end="72" /protein_start="33" /score="39.1" /tool="antismash" /translation="FYLEQITMKVKGSLNIKCLEESMNVIMDRYDVFRTVFIH" CDS_motif 1850..1915 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg15_2_0003" /evalue="1.70E-11" /label="C3_DCL_135-156" /locus_tag="ctg15_2" /protein_end="166" /protein_start="144" /score="36.5" /tool="antismash" /translation="YHHIILDGWCFGIVVQDLFKVY" CDS_motif 1961..1999 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg15_2_0004" /evalue="5.50E-04" /label="C4_DCL_171-183" /locus_tag="ctg15_2" /protein_end="194" /protein_start="181" /score="12.4" /tool="antismash" /translation="PYKDYIKWLEKQD" CDS_motif 2237..2332 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg15_2_0005" /evalue="1.30E-18" /label="C5_DCL_263-294" /locus_tag="ctg15_2" /protein_end="305" /protein_start="273" /score="59.4" /tool="antismash" /translation="DLAFGTVVSGRPAEIKGVEHMVGLFINVVPRR" CDS_motif 2381..2494 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg15_2_0006" /evalue="1.20E-17" /label="C67_DCL_14fromHMM" /locus_tag="ctg15_2" /protein_end="359" /protein_start="321" /score="56.3" /tool="antismash" /translation="QEQLLQSEPHQYVPLYDIQSQADQPKLIDHIIVFENYP" aSDomain 2825..4018 /aSDomain="AMP-binding" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg15_2_AMP-binding.1" /evalue="2.10E-111" /label="ctg15_2_AMP-binding.1" /locus_tag="ctg15_2" /protein_end="867" /protein_start="469" /score="364.3" /specificity="substrate consensus: Leu" /tool="antismash" /translation="FKEAVNVNPDAPALTYSGQTLSYRELDEEANRLARRLQKHGAGKG SVVALYTKRSLELVIGILGVLKAGAAYLPVDPKLPEDRISYMLADSAAACLLTHQEIKE QVAELPYTGTTLFIDDQTRFEEQASDPATAIDPNDPAYIMYTSGTTGKPKGNITTHANI QGLVKHVDYMAFSDQDTFLSVSNYAFDAFTFDFYASMLNAARLIIADEHTLLDTERLTD LILQENVNVMFATTALFNLLTDAGEDWMKGLRCVLFGGERASVPHVRKALRVMGPGKLI NCYGPTEGTVFATAHVVHDLPDSISSLPIGKPISNASVYILNEQSQLQPFGAIGELCIS GMGVSKGYVNRADLTKEKFINNPFKPGETLYRTGDLARWLPDGTIEYAGRIDDQVKIR" CDS_motif 3011..3052 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg15_2_0007" /evalue="2.60E-05" /label="NRPS-A_a2" /locus_tag="ctg15_2" /protein_end="545" /protein_start="531" /score="17.4" /tool="antismash" /translation="LGVLKAGAAYLPVD" CDS_motif 3245..3304 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg15_2_0008" /evalue="9.20E-08" /label="NRPS-A_a3" /locus_tag="ctg15_2" /protein_end="629" /protein_start="609" /score="24.4" /tool="antismash" /translation="AYIMYTSGTTGKPKGNITTH" CDS_motif 3812..3901 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg15_2_0009" /evalue="5.50E-13" /label="NRPS-A_a6" /locus_tag="ctg15_2" /protein_end="828" /protein_start="798" /score="41.1" /tool="antismash" /translation="PFGAIGELCISGMGVSKGYVNRADLTKEKF" CDS_motif 3983..4048 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg15_2_0010" /evalue="9.60E-12" /label="NRPS-A_a8" /locus_tag="ctg15_2" /protein_end="877" /protein_start="855" /score="36.8" /tool="antismash" /translation="YAGRIDDQVKIRGHRIELEEIE" aSDomain 4337..4543 /aSDomain="PCP" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg15_2_PCP.1" /evalue="1.30E-25" /label="ctg15_2_PCP.1" /locus_tag="ctg15_2" /protein_end="1042" /protein_start="973" /score="81.3" /tool="antismash" /translation="EETIAQIWSEVLGRKQIGIHDDFFALGGHSLKAMTAASRIKKELG IDLPVKLLFEAPTIAGISAYLKNG" aSDomain 4598..5182 /aSDomain="Thioesterase" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg15_2_Thioesterase.1" /evalue="5.20E-37" /label="ctg15_2_Thioesterase.1" /locus_tag="ctg15_2" /protein_end="1255" /protein_start="1060" /score="120.3" /tool="antismash" /translation="IFAFPPVLGYGLMYQNLSSRLPSYKLCAFDFIEEEDRLDRYADLI QKLQPEGPLTLFGYSAGCSLAFEAAKKLEEQGRIVQRIIMVDSYKKQGVSDLDGRTVES DVEALMNVNRDNEALNSEAVKQGLKQKTHAFYSYYVNLISTGQVKADIDLLTSGADFDM PEWLASWEEATTGVYRVKRGFGTHAEMLQGET" CDS_motif 4742..4816 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg15_2_0011" /evalue="6.30E-10" /label="NRPS-te1" /locus_tag="ctg15_2" /protein_end="1133" /protein_start="1108" /score="31.5" /tool="antismash" /translation="QPEGPLTLFGYSAGCSLAFEAAKKL" CDS 5274..6002 /NRPS_PKS="Domain: Thioesterase (14-231). E-value: 3.4e-55. Score: 179.8. Matches aSDomain: nrpspksdomains_ctg15_3_Thioesterase.1" /gene_functions="biosynthetic-additional (rule-based-clusters) Abhydrolase_6" /gene_functions="biosynthetic-additional (rule-based-clusters) PF00561" /gene_functions="biosynthetic-additional (smcogs) SMCOG1004:thioesterase (Score: 212.1; E-value: 1.1e-64)" /gene_kind="biosynthetic-additional" /locus_tag="ctg15_3" /sec_met_domain="Abhydrolase_6 (E-value: 4.3e-15, bitscore: 49.8, seeds: 455, tool: rule-based-clusters)" /sec_met_domain="PF00561 (E-value: 1e-06, bitscore: 21.4, seeds: 48, tool: rule-based-clusters)" /transl_table=11 /translation="MSQLFKSFDASEKTQLICFPFAGGYSASFRPLHAFLQGECEMLAA EPPGHGTNQTSAIEDLEELTDLYKQELNLRPDRPFVLFGHSMGGMITFRLAQKLEREGV FPQAVIISAIQPPHIQRKKVSHLPDDQFLDHIIQLGGMPAELVENKEVMSFFLPSFRSD YRALEQFELFDLAQIQSPVHVFNGLDDKKCIRDAEGWKKWAKDITFHQFDGGHMFLLSQ TEEVAERIFAILNQHPIIQP" aSDomain 5316..5966 /aSDomain="Thioesterase" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg15_3_Thioesterase.1" /evalue="3.40E-55" /label="ctg15_3_Thioesterase.1" /locus_tag="ctg15_3" /protein_end="231" /protein_start="14" /score="179.8" /tool="antismash" /translation="QLICFPFAGGYSASFRPLHAFLQGECEMLAAEPPGHGTNQTSAIE DLEELTDLYKQELNLRPDRPFVLFGHSMGGMITFRLAQKLEREGVFPQAVIISAIQPPH IQRKKVSHLPDDQFLDHIIQLGGMPAELVENKEVMSFFLPSFRSDYRALEQFELFDLAQ IQSPVHVFNGLDDKKCIRDAEGWKKWAKDITFHQFDGGHMFLLSQTEEVAERIF" CDS_motif 5499..5570 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg15_3_0001" /evalue="1.90E-08" /label="NRPS-te1" /locus_tag="ctg15_3" /protein_end="99" /protein_start="75" /score="26.7" /tool="antismash" /translation="PDRPFVLFGHSMGGMITFRLAQKL" CDS 6103..7329 /gene_functions="transport (smcogs) SMCOG1137:Major facilitator superfamily MFS 1 (Score: 337.5; E-value: 1.5e-102)" /gene_kind="transport" /locus_tag="ctg15_4" /transl_table=11 /translation="MRTSPRMKWFVLLFTFVFAIGMNSFRNSFQFFMLPMADAFHADRS LISVSVSIFMITTGIVQFFVGFFIDRFSVRKIMALGAVCISASFLVLPYSPNVHVFSAI YGVLGGIGYSCAVGVTTQYFISCWFDTHKGLALAILTNANSAGLLLLSPIWAAAPYHAG WQSTYIILGIVMAAVLLPLLVFGMKHPPHAQAESVKKSYDWRGFWNVMKQSRLIHILYF GVFTCGFTMGIIDAHLVPILKDAHVSHVNGMMAAFGAFIIIGGLLAGWLSDLLGSRSVL LSILFFIRLLSLICLLIPILGIHHSDLWYFGFILLFGLSYTGVIPLTAASISESYQTGL IGSLLGINFFIHQVAGALSVYAGGLFFDMTHGYLLIVAVCIVFVGLSAVIELVPFLDKQ KAKETHQSI" CDS complement(7344..7901) /locus_tag="ctg15_5" /transl_table=11 /translation="MIQYANESINLPGEIAFKDVREIFFYQIAKISCFYFLLFCAIFAA VNFINGWPRIVYGSDALNLFMNSMLIIVMSVLFTLLLLLLLYVKFSRAYKKNERMKSKR TYTLNQEGIRICSKKYDLIFNWDEITAVFEYKNIFRVNTSSGQYIAIPKRFFHSKEEIN RFKEIILKNTGTKKLKFKKDQH" CDS complement(7955..8893) /gene_functions="transport (smcogs) SMCOG1166:transporter, EamA family (Score: 155.8; E-value: 2.6e-47)" /gene_kind="transport" /locus_tag="ctg15_6" /transl_table=11 /translation="MVKHQQAPAYIAAILYSFIIGLSFLFVKIALQTAEPFDILAHRFT IAFAAATVPILFGWVKLSIRVKDVIAILPLALLYPALFFSFQAFGLVYSSSSEAGIIQA AIPIFTMVFAAYVLKERPTWTQKGFTVLSVAGVMFIFVMKGVDVESASLKGSLLILLSA LSSAMYNTAARKMTQRFKLTELTYIMSAIGFVVFNAIALVRHGAAGTVGTYFLPFREPG FVLGIVYLGVLSSLVTSFLSNYTLSRIEAFKMSAFNHVSTIVTMIAGVVILKESLAWYH LAGAVCIMIGVVGSNINLEKKTKRPGMPAKK" CDS 9017..10351 /NRPS_PKS="Domain: Aminotran_1_2 (90-438). E-value: 5.3e-23. Score: 73.5. Matches aSDomain: nrpspksdomains_ctg15_7_Aminotran_1_2.1" /gene_functions="biosynthetic-additional (rule-based-clusters) Aminotran_1_2" /gene_functions="biosynthetic-additional (smcogs) SMCOG1019:aminotransferase (Score: 263.8; E-value: 4.3e-80)" /gene_kind="biosynthetic-additional" /locus_tag="ctg15_7" /sec_met_domain="Aminotran_1_2 (E-value: 1.1e-22, bitscore: 73.5, seeds: 48, tool: rule-based-clusters)" /transl_table=11 /translation="MEKYMSLVTRIEEMMQSTSYQEGDRLPSIRQLSARYQVSKSTVIR ALQELEKRHLIYSVPKSGYYIVKKTGKAKSGQPGPIDFATSAPDPNVFPYLDFQHCINK AIDTYKNDLFIYGTPKGLPSLIRVLRKLLATQQVFADERHIFITSGVQQALSLLCAMPF PNGKEKIAIEQPGYHLMVEQLETLGIPAIGVKRTEEGLDIAEVERLFQTESIKFFYTMP RFHNPLGCSLSERDKQELVRLAEAYDVYLVEDDYLGDLEENKKADPLYAYDLSSHVIYL KSFSKMIFPGLRVGAAVLPEALTDTFYAYKKLNDIDCSMISQAALEIYLKSGMYGRHKE KIRDSYKERSLRLHQAIRTHRQLGSGRFTFSSGQAPCMHTHLVLPQDLPASRVIHRLKK QGVLLEAIDRHYLSDYPKENLLKINISNVKTEDIERGVKLLMSHL" aSDomain 9287..10330 /aSDomain="Aminotran_1_2" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg15_7_Aminotran_1_2.1" /evalue="5.30E-23" /label="ctg15_7_Aminotran_1_2.1" /locus_tag="ctg15_7" /protein_end="438" /protein_start="90" /score="73.5" /tool="antismash" /translation="NVFPYLDFQHCINKAIDTYKNDLFIYGTPKGLPSLIRVLRKLLAT QQVFADERHIFITSGVQQALSLLCAMPFPNGKEKIAIEQPGYHLMVEQLETLGIPAIGV KRTEEGLDIAEVERLFQTESIKFFYTMPRFHNPLGCSLSERDKQELVRLAEAYDVYLVE DDYLGDLEENKKADPLYAYDLSSHVIYLKSFSKMIFPGLRVGAAVLPEALTDTFYAYKK LNDIDCSMISQAALEIYLKSGMYGRHKEKIRDSYKERSLRLHQAIRTHRQLGSGRFTFS SGQAPCMHTHLVLPQDLPASRVIHRLKKQGVLLEAIDRHYLSDYPKENLLKINISNVKT EDIERGVK" CDS complement(10346..11020) /NRPS_PKS="Domain: ACPS (103-166). E-value: 6e-20. Score: 63.4. Matches aSDomain: nrpspksdomains_ctg15_8_ACPS.1" /gene_functions="biosynthetic-additional (smcogs) SMCOG1012:4'-phosphopantetheinyl transferase (Score: 189.2; E-value: 1.1e-57)" /gene_kind="biosynthetic-additional" /locus_tag="ctg15_8" /transl_table=11 /translation="MKIYGIYMDRPLSQEENERFMSFISPEKREKCRRFYHKEDAHRTL LGDVLVRSVISRQYQLDKSDIRFSTQEYGKPCIPDLPDAHFNISHSGRWVIGAFDSQPI GIDIEKTKPISLEIAKRFFSKTEYSDLLAKDKDEQTDYFYHLWSMKESFIKQEGKGLSL PLDSFSVRLHQDGQVSIELPDSHSPCYIKTYEVDPGYKMAVCAAHPDFPEDITMVSYEE LL" aSDomain complement(10523..10711) /aSDomain="ACPS" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg15_8_ACPS.1" /evalue="6.00E-20" /label="ctg15_8_ACPS.1" /locus_tag="ctg15_8" /protein_end="166" /protein_start="103" /score="63.4" /tool="antismash" /translation="IGIDIEKTKPISLEIAKRFFSKTEYSDLLAKDKDEQTDYFYHLWS MKESFIKQEGKGLSLPLD" CDS complement(11125..11772) /locus_tag="ctg15_9" /transl_table=11 /translation="MKQELVLRWTFYFAGLIILAFGVSLTIEGKALGISPWDAFHYSLF QHFGLTVGQWSIIIGALIVGFTSLFTRAWPKIGALLNMVLIGVFIDFFNFILPAPSTYT GSIIVFSLGVVLIGYGVGVYVSAGLGAGPRDSLMMLITEKTGWNVQWVRNGMEITILFA AWGMGGPIGFGTILTAILTGLILRFSLPQSIQLLNYAVARRTAAVKASPPVH" CDS complement(12093..12836) /gene_functions="transport (smcogs) SMCOG1000:ABC transporter ATP-binding protein (Score: 222.1; E-value: 1.3e-67)" /gene_kind="transport" /locus_tag="ctg15_10" /transl_table=11 /translation="MLTVKGLNKSFGENEILKKIDMKIEKGKVIAILGPSGSGKTTLLR CLNALEIPNRGELAFDDFSIDFSKKVKQADILKLRRKSGMVFQAYHLFPHRTALENVME GPIQVQKRNKEEVRKEAIQLLDKVGLKDKMDLYPFQLSGGQQQRVGIARALAIQPELML FDEPTSALDPELVGEVLKVIKDLANEGWTMVVVTHEIKFAQEVADEVIFIDGGVIVEQG PPEQIFSAPKEERTQRFLNRILNPL" CDS complement(12850..13554) /gene_functions="transport (smcogs) SMCOG1096:polar amino acid ABC transporter, inner membrane (Score: 244.4; E-value: 1.7e-74)" /gene_kind="transport" /locus_tag="ctg15_11" /transl_table=11 /translation="MFLNNLPALTLGTAIPWDLVQQSFWPILSGGIYYTIPLTILSFIF GMILALITALARMSKVRPLRWVFSVYVSAIRGTPLLVQLFIIFYLFPAFNVTLDPFPSA VIAFSLNVGAYASEIIRASILSVPKGQWEAGYTIGMTHQKTLFRVILPQAFRVSIPPLS NTFISLIKDTSLASQILVAELFRKAQEIGARNLDQILVIYIEAAFIYWIICFLLSLVQH VIERRLDRYVAK" CDS complement(13541..14347) /gene_functions="biosynthetic-additional (smcogs) SMCOG1091:glutamine-binding lipoprotein glnH (Score: 234.5; E-value: 1.7e-71)" /gene_kind="biosynthetic-additional" /locus_tag="ctg15_12" /transl_table=11 /translation="MKKALLALFMVVSIAALAACGAGNDNQSKDNAKDGDLWASIKKKG VLTVGTEGTYEPFTYHDKDTDKLTGYDVEVITEVAKRLGLKVDFKETQWDSMFAGLNSK RFDVVANQVGKTDREDKYDFSDKYTTSRAVVVTKKDNNDIKSEADVKGKTSAQSLTSNY NKLATNAGAKVEGVEGMAQALQMIQQGRVDMTYNDKLAVLNYLKTSGNKNVKIAFETGD PQSTYFTFRKGSGEVVDQVNKALKEMKEDGTLSKISKKWFGEDVSK" CDS complement(14463..15335) /gene_functions="regulatory (smcogs) SMCOG1014:LysR family transcriptional regulator (Score: 246.3; E-value: 6.3e-75)" /gene_kind="regulatory" /locus_tag="ctg15_13" /transl_table=11 /translation="MDIRQLRYFITIAQEQKITSAAKKLHMAQPPLSRQLKQLEDELGV VLFDRNKKKQMTLTYEGAVFLKRAKEILHRFEDAVIEVQELKEEVAGTLAVGSTIYCAA LMLEKVTQIKERYPHLTFNIWENEPATLLELLESRQIDAAVTTTLIKSDTVQFKQLDDI PCVLVLSDEAGYPCGDTIKMEDIPSFPLILLRPVNGKGVYNQVMNEFHRLNLEPRIVCE CHDSATLLSLVSSGFGASILPVTMIPVHMRNHVHTVHIENNPFIMTPAVMWRTDSYLPK PAQQFLDLF" CDS 15425..16039 /gene_functions="biosynthetic-additional (rule-based-clusters) Flavoprotein" /gene_kind="biosynthetic-additional" /locus_tag="ctg15_14" /sec_met_domain="Flavoprotein (E-value: 8.7e-33, bitscore: 105.9, seeds: 143, tool: rule-based-clusters)" /transl_table=11 /translation="MKAEFKRKGGGKVKLVVGMTGATGAIFGVRLLQWLKAAGVETHLV VSPWANVTIKHETGYTLQEVEQLATYTYSHKDQAAAISSGSFDTDGMIVAPCSMKSLAS IRTGMADNLLTRAADVMLKERKKLVLLTRETPLNQIHLENMLALTKMGTIILPPMPAFY NQPSSLEEMVDHIVFRTLDQFGIRLPEAKRWNGIEKQKGGA" CDS 16042..17463 /locus_tag="ctg15_15" /transl_table=11 /translation="MAYQDFREFLAALEKEGQLLTVNEEVKPEPDLGAAARAASNLGDK SPALLFNNIYGYHNARIAMNVIGSWPNHAMMLGMPKDTPVKEQFFEFAKRYDQFPMPVK REETAPFHENEITEDINLFDILPLFRINQGDGGYYLDKACVISRDLEDPDNFGKQNVGI YRMQVKGKDRLGIQPVPQHDIAIHLRQAEERGINLPVTIALGCEPVITTAASTPLLYDQ SEYEMAGAIQGEPYRIVKSKLSDLDVPWGAEVVLEGEIIAGEREYEGPFGEFTGHYSGG RSMPIIKIKRVYHRNNPIFEHLYLGMPWTECDYMIGINTCVPLYQQLKEAYPNEIVAVN AMYTHGLIAIVSTKTRYGGFAKAVGMRALTTPHGLGYCKMVIVVDEDVDPFNLPQVMWA LSTKMHPKHDAVIIPDLSVLPLDPGSNPSGITHKMILDATTPVAPETRGHYSQPLDSPL TTKEWEQKLMDLMNK" CDS 17522..17707 /locus_tag="ctg15_16" /transl_table=11 /translation="MSKSPVEGAWEVYQCQTCFFTWRSCEPESITNPEKYNPAFKIDPK ETETAIEVPAVPERKA" CDS 17704..18168 /locus_tag="ctg15_17" /transl_table=11 /translation="MIRVNCMSDRLFELLDGSCLNEKQHEAFVLQTVSEDGWPHAAMIS AGEIIALSRTDIRIALWKNTMTSANILRTGKAQFTAWWKGAAYYVKLECAPLPPLKDAE YERDRFSCRIVSVKEDVAKYADLTSGVRIQLHSAEEVLSRWEKTLEDLKR" CDS 18234..19079 /gene_functions="biosynthetic-additional (rule-based-clusters) PF00561" /gene_functions="biosynthetic-additional (rule-based-clusters) Abhydrolase_6" /gene_functions="biosynthetic-additional (smcogs) SMCOG1036:alpha/beta hydrolase fold protein (Score: 66.3; E-value: 5.8e-20)" /gene_kind="biosynthetic-additional" /locus_tag="ctg15_18" /sec_met_domain="PF00561 (E-value: 2.1e-15, bitscore: 49.9, seeds: 48, tool: rule-based-clusters)" /sec_met_domain="Abhydrolase_6 (E-value: 5.2e-09, bitscore: 29.9, seeds: 455, tool: rule-based-clusters)" /transl_table=11 /translation="MERAGICHSDGFDLAYRIEGEGAPILVIGSAVYYPRLFSPDIKQK YQWVFIDHRGFAKPKRGLRAEDSRLDAVLADIERMRTFLQLEDVTILGHSGHAFMALEY ARTYPKQVRKVALFNTAPDNSEERQRKSESFFMETASLERKKRFEKDIANLQQDIDKDP ERRFVHMCIRAEAKSFYQERPHAAALWDGVFTNMPIIDELWGNTFARIDLIQRLADVRM PVYIGLGRYDYLVAPVALWDAVDCLYPHVDKVIFEKSGHQPMLEEPEAFDQSFRKWLDQ " CDS complement(19119..20597) /gene_functions="transport (smcogs) SMCOG1202:major facilitator transporter (Score: 52.1; E-value: 6.3e-16)" /gene_kind="transport" /locus_tag="ctg15_19" /transl_table=11 /translation="MASIDNESIIKSVPQKGFFGHPRGLFTLFFTEFWERFSYYGMRAI LLYYLYTETVNGGLGFDKGTAVAIMSIYGSLVYMSTIIGGWLADRVFGTANTVFYGGIF IMFGHIALAYPGSAIAFYISMVLIIVGTGLLKPNVSSVVGDLYTKEDPRRDSGFSIFYM GINLGGLLAPLIVGTLGQKYNYHLGFGAAAVGMLLGLIVFALTRKKNLGLAGSNVPNPL SKKSAIGTGIGVIIVAIAVMISVQTGVLTINRFIDLVSILGILIPVIYFIIMFTSKKAD STEKSRLAAYIPLFIGAVMFWAIQEQGATILAVYADERIRLSLGGFELQSSWFQSLNPL FVVIFAPIFAWLWMKLGKRQPSTPVKFSIGIILAGLSFIIMVFPAMQGKEALVSPLWLV LSFLLVVLGELCLSPVGLSVTTKLAPAAFSAQTMSMWFLTNAAAQAINAQVAGLFDKIP ETMYFGTIGLISIVLGGILLLLSPMIKRAMKGVL" CDS 20877..22631 /locus_tag="ctg15_20" /transl_table=11 /translation="MAEFILNAADFGVPGDGKTDSTERINQCLSTAVSKGYHTVWFPKG TYLIDATLGGDLNQKFRNAGIIVPGNLEIMMDPECIMKVIPNSSWGYSAFYVGKQENIT ISGGQIIGERDEHTYASAGIRSTHEWGFGICIEGCSNVVIDDVKISDFTGDGIIVSPRG LKTNQDYRTSEQIIIRRCEVRRSRRNNISITGCDMVTVEECLIEDAGTGNGTAPKFGID IEGYGEGDVDYEEPINVSIRNNHFVGNVSSSVTNFNGYGILIEGNHSDNTISYGYGTQT VIKGNILRRPEDAAAAPRVGITGLGVSQGKETSDAVIAGNLITGFSTGIDVRGKSVLVT NNKISNFENTGILVYQSSDVKVDGNQIQNGLSETRRSIGLRAVLSDDTAFLNNCLIQVV DGVSVSGGNMIIKDNLLRKFSRGIWIAQGNAVIEGNTLNPGAFEAVPESYSVSVTNNAG AIIKNNTFKEFKNYPIYCSTSAKTSIIGNHLERSPLLVTIYISAGVHEIFDNTISVNRT AGNPIVIYLNGSAGSIISGNTINNLSAGTATAIQTNTSTNSKIIGNRIFKGTINKHSSD AIDGNIIV" CDS complement(22646..22867) /locus_tag="ctg15_21" /transl_table=11 /translation="MKILGVTGVILICLLAISVLMDMLQGFSLTKAIYNNMSSFKMTTF AEWVVLLFFVLVLVREMYVIYKSKKKNP" CDS 22993..24627 /locus_tag="ctg15_22" /transl_table=11 /translation="MPLFSKRKNNTSSKDKRNTEEKNQEQKQEKERPVLISPSLAKNIA ETKKEVGSSSDVIIREIKIGEQDHVHLAVIYIAGLVDNNTIHESLIDPLVQDESIQNTH AIQQILEKTLPLGGVKAEKSWDKLFSELMLGNALIFADGYDEALICSTQGGEQRSIQEP STQVSFRGPRQGFTESLQTNISMIRRYIKNQNLWVEKMKKGSVTNTDIALMYIQGICDE KVLKEVKQRLEKIDIDSILESGYIEQLIEDETFTTFPTMYHTERPDVVAGNLLEGRFAI IVDGTPFVLIAPALFVQFFQSVEDYYSRFDIATSIRILRVLVFFISLVAPAVYVAATTF HQEMIPTQLLVVIAAQREIVPFPAVVEALTMEVAFEILREAGVRLPRVVGSAVSIVGAL VIGQAAVQAGIVSPAMVIIVALTAIASFATPAFAMAISARLIRFIFIIASAVMGFYGLI LGIIMMFVHLCSLRSFGVPYMSPLAPFSSQGVKDALFRIPWWADEKRPESISKEDKVRQ GKDQRPEPAASRGMVNKDLEEGDQNGT" ORIGIN 1 gccgatccag cgctggttct ttgaaaagaa cttcacgaac aagcaccact ggaaccaatc 61 ggtgatgctt cacgccgcga agggctttga ccctgaacgg gtggagaaaa cattgcaggc 121 gctgatcgag catcatgacg cgctccgcat ggtctatcgt gaggaaaacg gggacatcgt 181 tcaggcgtat aaaccgatcg gtgagagcaa ggtcagcttc gaaatcgtgg atctgtacgg 241 ctctgatgaa gagatgctga gaagccagat taagattctc gcgaacaagc tgcaaagcag 301 tctcgatctg agaaccgggc cgcttttaaa ggcggagcaa tatcgcacag aagctgggga 361 tcacctgctc attgctgtac accatctcgt ggtcgacggt gtgtcatggc ggattttgct 421 tgaagacttt gcttcaggct acatgcaggc tgagaaagaa gagagccttg tcttcccgca 481 aaaaacaaac tccttcaagg actgggcgga agaactggcg gcattcagcc aatcagcgca 541 tcttttacag caggctgaat actggtcgca aattgccgct gaacaggttt ctcctttacc 601 gaaggattgt gaaacagagc agcggatcgt caaggataca tcatccgtcc tatgtgaatt 661 aacggaagaa gacactaagc atcttttaac agatgttcat cagccatatg gaactgaaat 721 caacgatatt cttctcagtg cgctcggttt gacaatgaaa gaatggacaa agggtgccaa 781 aattggcatt aaccttgagg gacacggccg ggaggacatc atcccgaatg tgaatatctc 841 cagaacggtc ggctggttta cggcacaata ccctgttgtg ctcgacatat ctgacgcaga 901 tgcctcggct gtgatcaaaa cagtcaaaga aaacctgcgc cgcattcccg acaaaggtgt 961 tggctacggc attcttcgtt atttcacaga aacagcggaa acaaagggct tcacaccgga 1021 gatcagcttc aactatttgg gccaattcga cagtgaagtc aaaaccgatt tctttgaacc 1081 atccgctttc gatatggggc gccaagtaag cggagaatca gaggcgctgt acgctttaag 1141 cttcagcggc atgatcagaa acggccagtt tgtgctttcc tgctcctaca atgagaagga 1201 gtttgaaaga gctacagtcg aggagcaaat ggaacggttt aaagaaaacc tcctgatgct 1261 aatccgccat tgcacggaaa aagaagacaa ggaattcaca ccaagcgact tcagcgccga 1321 agaccttgaa atggacgaga tgggagatat ctttgacatg cttgaggaga atttaaaata 1381 aaacgcaagg gaattacaga aggcgggagc gaaacatatg agtcaattta gcaaggatca 1441 ggttcaagat atgtattacc tatcgccgat gcaggaaggg atgctttttc atgccatcct 1501 gaatcccggc caaagctttt accttgaaca aatcacgatg aaagtaaaag gcagcttgaa 1561 tatcaaatgt cttgaagaaa gcatgaatgt gatcatggac cggtacgatg tatttcgtac 1621 cgtgttcatt cacgaaaaag taaaaagacc tgtccaagtc gtattgaaaa aaaggcagtt 1681 ccatatagaa gaaatcgatc tgacacactt aacgggcagc gagcaaacag ccaaaatcaa 1741 tgagtacaaa gaacaggata agatcagggg ttttgatttg acgcgggata ttccgatgcg 1801 ggcagccatt ttcaagaaag ctgaagaaag ctttgaatgg gtgtggagct accaccacat 1861 tattttggac ggatggtgct tcggcatcgt cgtacaggat ctatttaagg tatacaatgc 1921 tctgcgcgaa caaaagccgt acagcctgcc ccccgtcaaa ccgtataaag actacatcaa 1981 gtggcttgaa aagcaggata aacaagcatc actgcgttac tggcgcgagt atttagagga 2041 ctttgaagga caaacgacgt ttgcggagca aagaaagaaa caaaaggacg gctatgagcc 2101 gaaagagctg ctcttttcac tgccggaggc ggaaacaaag gcctttaccg agcttgcaaa 2161 atcgcagcat accactttaa gtacggcgct gcaggcagtc tggagcgtat tgatcagccg 2221 ctatcagcag tctggcgatt tggccttcgg tacagttgtt tcagggcgtc ccgcggaaat 2281 caaaggcgtt gaacatatgg tcgggctgtt tatcaacgtt gtcccgagac gtgtgaagct 2341 gtctgagggt atcacattta acggcttgct caagcagctg caggagcaat tgctgcagtc 2401 tgagccgcat caatatgtgc cgctttatga catccaaagc caggccgatc agccgaaact 2461 gattgaccac atcattgttt ttgagaacta tccgcttcag gatgcgaaaa atgaagaaag 2521 cagtgaaaac ggctttgata tggtggatgt tcatgttttt gagaagtcga attatgatct 2581 caacctgatg gcttccccgg gagatgagat gctgattaag cttgcctata atgagaatgt 2641 gtttgatgag gcgtttatcc tgcgcttgaa atctcagctt cttacagcaa ttcagcagct 2701 catccagaat ccggatcagc ctgtcagcac gatcaacctc gttgacgaca gggagagaga 2761 atttttgcta accggcttaa acccgccggc tcaagctcat gaaacaaagc ctctgacgga 2821 ttggttcaag gaagcagtga acgtcaatcc ggatgcgccg gcgcttacgt attccggcca 2881 gaccctgtct tatcgcgaat tagatgagga agcgaaccgc cttgcacgcc ggctgcaaaa 2941 acacggtgcg ggcaaaggct ctgttgtagc gctgtacacg aagcgctcac ttgaactggt 3001 aatcggcatt ctcggtgtat taaaggcggg agcagcctat ctgccggttg atccgaagct 3061 gccagaggac cgaatctcgt atatgctggc tgacagtgcg gcagcctgtc ttctgacgca 3121 tcaggagata aaagaacaag tggctgagtt gccgtataca ggcacaacgc tcttcattga 3181 tgatcaaaca cggtttgaag aacaggcaag cgatcctgca accgcgattg atcctaatga 3241 tccggcatat atcatgtaca cgtccggcac aaccggaaag ccaaagggca atatcaccac 3301 tcatgccaat attcaaggat tggtcaagca tgtagactac atggcatttt ctgatcagga 3361 tacgttcttg tctgtttcca attacgcctt tgacgcattt acctttgatt tctatgcttc 3421 tatgctgaat gcggcacggc tcattatcgc agatgaacat acgctgcttg atacagaacg 3481 gctcacagat ctgatcctgc aagagaatgt caatgtcatg tttgcgacaa ccgcactatt 3541 taatcttctc acagatgcgg gagaggattg gatgaagggg cttcgctgcg tgttattcgg 3601 cggagagcgc gcctcagtgc ctcatgtcag aaaagcgctg cgggtcatgg ggccgggcaa 3661 gctgattaac tgctacgggc cgactgaggg aacagtgttt gcgacagctc acgtcgtgca 3721 tgatctgccg gattccatct cctcattgcc gattggaaag ccgatcagca atgccagtgt 3781 ttatattctg aacgagcaaa gccagctcca gccattcggg gcgatcggtg aactgtgcat 3841 cagcggaatg ggcgtgtcaa aaggatatgt aaatcgtgct gacctcacga aggaaaagtt 3901 tattaacaac ccgttcaagc cgggagaaac gctttaccgc acaggggatt tagcgcgctg 3961 gctgccggat ggaacgattg aatacgccgg ccgtattgac gaccaggtca aaatacgcgg 4021 acaccggatt gagcttgaag aaatcgaaaa gcagctgcag gaatacccag gtgtgaaaga 4081 tgcggtcgtt gtggcggacc gccctgagtc tggcgatgca tcaatcaatg cctaccttgt 4141 gaaccggacg cagctttcag ctgaggacgt gaaggcgcac ctgaaaaaac agcttcctgc 4201 ttacatggtg ccgcaaacct ttaccttctt ggatgagatt cctttaacga cgaacgggaa 4261 agtcaataaa cggctgctcc caaaacctga tcaggatcag ctggcggaag aatggatcgg 4321 accgcggaac gagatggaag aaacaatcgc acaaatatgg tctgaggttc tcggcagaaa 4381 gcaaattggc attcatgacg atttctttgc gctcggaggg cattccttga aggccatgac 4441 cgccgcgtcc cgcatcaaga aagagctcgg gattgatctt ccagtaaagc ttttgtttga 4501 agcgccgacg atcgccggca tttcagcgta tttgaaaaat gggggtcctg atcgcttgca 4561 ggatgtaacg ataatgaatc aggatcagga gcagatcatt ttcgcattcc cgccggtctt 4621 gggctatggt cttatgtacc aaaatctgtc cagccgcttg ccgtcataca agctgtgcgc 4681 ctttgatttt attgaggagg aagaccggct tgaccgctat gcggatttga tccagaagct 4741 gcagccggaa gggcctttaa cattgtttgg atattcagcg ggatgcagcc tggcgtttga 4801 agctgcgaaa aagcttgagg aacaaggccg tattgttcag cggatcatca tggtggattc 4861 ctataaaaaa caaggtgtca gtgatctgga cggacgcacg gttgaaagtg atgtcgaagc 4921 gttgatgaat gtcaatcggg acaatgaagc gctcaacagc gaagccgtca aacaaggcct 4981 caagcaaaaa acacatgcct tttactcata ctacgtcaac ctgatcagca caggccaggt 5041 gaaagcagat attgatctgt tgacttccgg cgctgatttt gacatgccgg aatggcttgc 5101 atcatgggaa gaagctacaa caggtgttta ccgtgtgaaa agaggcttcg gaacacacgc 5161 agaaatgctg cagggcgaaa cgctagatag gaatgccggg attttgctcg aatttcttaa 5221 tacacaaacc gtaacggttt cataaatgaa gtgatgaaag gaggagacag ccaatgagcc 5281 aactcttcaa atcatttgat gcgtcggaaa aaacacagct catctgtttt ccgtttgccg 5341 gcggctattc ggcgtcgttt cgccctctcc atgctttttt gcagggggag tgcgagatgc 5401 tcgctgccga gccgccggga cacggcacga atcaaacgtc agccattgag gatctcgaag 5461 agctgacgga tttgtacaag caagaactga accttcgccc tgatcggccg tttgtgctgt 5521 tcggacacag tatgggtgga atgatcacct tcaggctggc gcaaaagctt gagcgtgaag 5581 gcgtctttcc gcaggcggtt atcatttctg caatccagcc gcctcatatt cagcggaaga 5641 aagtgtccca cctgcctgat gatcagtttc tcgatcatat tatccaatta ggcggaatgc 5701 ccgcagagct tgttgaaaat aaggaggtca tgtccttttt cctgccttct ttccgatcag 5761 attaccgggc tcttgaacaa tttgagcttt tcgatctggc ccagatccag tcgcctgttc 5821 atgtctttaa cgggcttgat gataaaaaat gcatacgaga tgcggaaggg tggaagaagt 5881 gggcaaaaga catcacattc catcaatttg acggcgggca catgttcctg ctgtcacaaa 5941 cggaagaagt cgcagaacgg atttttgcga tcttgaatca gcatccgatc attcaaccgt 6001 gatcaaaagc ggacagcttc ggctgttccg ctttttttgt gttgaatgcc aatttctgca 6061 tggtataata gtcgaaatac tcaaataaag gcaggtcgaa acatgcgcac gtctcccagg 6121 atgaaatggt ttgtattgct gtttacgttt gttttcgcca tcggaatgaa ctcattcaga 6181 aattcctttc aattttttat gctgccaatg gcagacgcct tccatgccga caggtcgctg 6241 atttcggttt ctgtcagcat ttttatgatc acaaccggca tcgtccagtt ttttgtcggt 6301 ttttttatcg accgtttcag tgtcagaaaa attatggcgc tgggagctgt ttgcatcagc 6361 gcaagctttt tggtgcttcc ttattcaccg aatgttcatg tgttttccgc catttacggt 6421 gtgcttggcg gaatcgggta ttcctgcgcg gtcggcgtga cgacccagta tttcatcagc 6481 tgttggtttg acacacacaa aggtctggcg cttgctattt tgaccaatgc caactctgcg 6541 ggcctgctgc ttctctcgcc catttgggct gcggctccgt atcatgccgg ctggcagagc 6601 acctatatca ttttgggaat cgtcatggcg gctgttctgc tgccgctcct cgtctttggg 6661 atgaagcacc cgccgcatgc gcaagcggag tctgtgaaaa aatcttatga ttggcggggg 6721 ttttggaacg tgatgaagca atcccgcctt attcatatcc tgtacttcgg cgtgtttact 6781 tgcggattta caatgggaat tattgatgct cacctcgtcc cgatactgaa ggatgcgcat 6841 gtctctcatg tcaacggaat gatggccgcg ttcggggcgt ttatcatcat tggcggatta 6901 ttggcgggct ggctgtccga tctcctcggc agcagaagcg tcctgctatc catcttattt 6961 ttcattcggc tgctcagcct catttgcctg cttattccca ttctcggaat tcatcacagc 7021 gacctttggt acttcgggtt tatcctgtta ttcgggctca gttacacagg cgtgatcccg 7081 ctgaccgcgg cgtcaatttc ggaaagctat caaacaggat tgatcggatc gctgctaggc 7141 atcaatttct ttatccatca ggttgccgga gctctcagcg tgtatgcggg cggtttgttt 7201 tttgacatga ctcatggtta tttgctgatt gtcgctgtgt gcatcgtgtt tgtgggttta 7261 tcggctgtaa tagagctggt gccgttttta gataaacaaa aggcaaaaga aacccaccaa 7321 tcaatataaa aggatcagca ctgtcaatgc tgatcctttt taaatttgag tttttttgtt 7381 ccggtatttt taaggataat ctccttgaat ctgtttattt cctctttgga atgaaaaaaa 7441 cgttttggga tcgcaatata ttggccactt gatgtattga ccctgaagat atttttatat 7501 tcgaaaacag ctgtgatttc atcccaattg aaaatgaggt catatttttt agaacatata 7561 cgaattcctt cttgatttag agtatatgtt cttttagatt tcatccgttc gttcttcttg 7621 tatgctctgg aaaacttcac atatagaagc aggaggagca gcagtgtaaa cagaacggac 7681 atcacgataa tcaacatact gttcataaat aagttaagcg cgtcactgcc ataaacgata 7741 cggggccatc cgttaatgaa gttaactgca gcaaatatgg cgcaaaacaa cagaaagtaa 7801 aagcatgata tttttgcgat ttgataaaaa aagatttctc ttacatcctt aaaagcaatt 7861 tctcctggaa gattgatact ttcattagca tattgaatca tacggtaaac ctacacctct 7921 aaccatgttt ttcctttcag tctagcataa tttctcattt ttttgcaggc ataccagggc 7981 gctttgtttt tttctccaga ttgatattgc tccccaccac gccaatcata atacaaacag 8041 ccccggcaag atgataccag gccaggcttt ctttgagaat cacaactcct gcaatcatcg 8101 tcacaatggt agatacatga ttaaaagcgc tcattttaaa cgcctcaatt cgcgacagcg 8161 tatagttaga cagaaacgaa gtaacaagtg aagacagcac gcccaaatac acaatgccga 8221 gaacgaagcc gggctcccgg aacggcagaa aataagtgcc gactgttccc gccgctccgt 8281 gacgcacaag ggcgatggcg ttgaagacga caaagccgat ggctgacatg atgtaggtga 8341 gctcggtcag cttgaaccgc tgcgtcattt ttctggcagc agtattgtac atcgctgaag 8401 acaaagcgga caataggatc agcaaagacc cttttaagct ggctgattcc acgtcaacgc 8461 ctttcatcac aaaaataaac atgacgccgg caacggataa aaccgtgaac cccttttggg 8521 tccacgttgg gcgttccttt aaaacataag cggcaaagac catcgtgaaa atcggaatgg 8581 ctgcctgaat aattcccgct tcagaggagg acgagtacac aaggccgaat gcctgaaagc 8641 tgaaaaataa cgcgggatac agcagggcga gcggcaaaat ggcaatgacg tcctttacgc 8701 ggattgatag ctttacccag ccgaataaga tcggtacagt ggccgcagca aacgcaatgg 8761 tgaaccgatg cgccaaaata tcaaacggct ctgctgtttg cagtgcgatt tttacgaata 8821 gaaaggataa accgataatg aacgaatata aaatagccgc tatataagcg ggggcttgct 8881 gatgtttaac cataatggga atggctcctt tacctgaatt gcagcgccgg tcgctccctt 8941 tattgtatgg ccgcggtcag aacggtacaa tgagaaaaac aatgaactgt accggtacaa 9001 aacaggggga gaaggcatgg agaaatatat gagtctagta acgaggatag aggagatgat 9061 gcaaagcacc tcctatcaag aaggagacag gcttccatct atccgtcagc tgtccgcccg 9121 ctaccaagtc agcaaaagca cagtgatccg cgcgctgcag gagctggaaa aacgccacct 9181 tatctattcc gttccgaaaa gcggctacta tattgtgaaa aagacgggaa aagccaaaag 9241 cgggcagcct ggccccatcg attttgccac atctgcgccg gacccaaatg tgtttccgta 9301 tcttgatttt cagcactgca tcaacaaagc gattgatact tacaaaaacg atttgtttat 9361 ttatggtacg ccaaaggggc ttccatcact catccgtgtt ctccgaaagc tcttggccac 9421 tcaacaggta tttgcggatg aacggcatat tttcattaca tcaggtgtcc agcaggcgtt 9481 atctctgctt tgtgccatgc catttccaaa tgggaaagaa aagatcgcca ttgaacagcc 9541 gggctaccat ttgatggtcg aacagcttga gacgcttggg attcccgcca tcggggtgaa 9601 acgaacggaa gaagggcttg atatagccga ggttgagcgg ttatttcaaa cagaatcgat 9661 taaatttttt tatacgatgc cgcgcttcca taacccgctt gggtgctcat tgtcagagcg 9721 tgataaacag gagcttgtga gactggcaga agcgtatgat gtctacctcg ttgaggatga 9781 ttacctcggt gatctggagg aaaataaaaa ggcagatccg ctgtacgcat atgatctgtc 9841 ctcacatgtc atctatttga aaagcttctc gaaaatgata ttccccggcc ttcgcgtggg 9901 ggcggctgtt ttgcccgaag cgctgactga cacgttctat gcgtacaaaa aactgaacga 9961 catcgactgt tcgatgattt ctcaagcggc attggagatt tacctgaaaa gcggtatgta 10021 cggcaggcat aaggagaaaa tcagagattc ttataaagag cggtcgctga ggctacatca 10081 agccattcga actcacaggc agctgggaag cggacgcttt acgttctcca gcgggcaggc 10141 accctgtatg cacacccatc tggtgcttcc tcaggatctg cccgcctcaa gagtgattca 10201 tagactgaaa aaacaagggg ttctccttga ggcgatagac cgtcattatt tatcagatta 10261 tccgaaagaa aatctattaa aaatcaatat ttccaatgtg aaaacggaag atattgagcg 10321 cggtgtcaag ctgttgatga gccatttata aaagctcttc gtacgagacc attgtgatat 10381 cctcggggaa atcagggtgt gcggcgcata cagccatttt gtagccggga tcgacctcat 10441 acgttttgat atagcatggg gaatggctgt ccggaagctc aatggatact tgtccgtcct 10501 ggtgcaggcg cactgaaaaa gaatcaagcg gaagcgataa gcctttgcct tcctgtttga 10561 taaagctttc tttcattgac catagatgat aaaaatagtc tgtctgctcg tccttgtctt 10621 ttgctaaaag gtcgctgtac tctgtttttg aaaaaaagcg cttggcgatc tcaaggctga 10681 tcggtttcgt tttttcgata tctatgccga tcggctgtga atcaaacgca ccaatgaccc 10741 agcggccgga gtgagaaatg ttgaaatgag cgtcgggaag atcagggatg cacggcttcc 10801 cgtattcctg tgtgctaaag cggatatcgg atttgtccaa ctgatactgc ctgcttatga 10861 ctgagcgaac gagcacatct cccagcaggg tgcgatgagc atcttcttta tgataaaatc 10921 tccggcattt ctcccgtttt tcaggtgata tgaaagacat gaaccgttca ttttcttctt 10981 gtgaaagcgg gcggtccata taaattccgt aaatcttcat tctagatcct ccgtctgcaa 11041 aagattgtca aaaccatcct atcatacttc cacaagactc atatagagga gaaaataaaa 11101 aaacaaagcc aaggcggctt tgttttagtg tacaggcgga gatgctttca cagcggcggt 11161 ccgccttgcc acagcataat tcagcaactg gattgactgg ggcaatgaaa agcgcaaaat 11221 aagtcctgtg aggatggcgg tcaaaatggt gccaaaaccg atcggcccgc ccatgcccca 11281 tgccgcaaac aaaatggtta tttccatgcc gttccgcacc cattgcacat tccagccggt 11341 tttttctgta atcagcatca tcagtgaatc acgcggcccc gcgccaagcc ctgctgatac 11401 ataaacaccg acgccgtaac cgatcagcac cacgcctaga gagaagacga tgatcgagcc 11461 tgtgtaggtc gagggggcag gcagaatgaa attgaaaaaa tctataaata caccaatgag 11521 caccatattc aggagggccc caattttcgg ccaagctctc gtaaacaatg acgtgaatcc 11581 gacgatgagc gctccaataa tgatggacca ctggccgacg gtaagcccga agtgctgaaa 11641 caggctgtaa tgaaatgcat cccacggact aatgccgagt gcttttcctt ctatcgtcag 11701 ggatacacca aaagccaaaa tgatcaaacc ggcaaaataa aatgtccagc gcagaacaag 11761 ttcttgcttc acgtgaggtc ccttctttcg taaaaatcag tcgattgtca ttgtagcaca 11821 tctgacagaa gggcggaata ggcgaaaggg gcttaacaaa aaaacagggc cgccgcaggc 11881 gccctgtttc agcgtgttgg caaacccttg cattcgttgt caggcctgtg cttcggtgct 11941 cacgaattta acattcgctg tgctccaatg ctcggccttc ctagacttca aaggttttca 12001 atcacgctga aaatcacaaa atcctaaaac gaaaatcgtt ttaggatttt gtcaataatc 12061 tgaaacaggg cgcaggcgcc ctgtttttct tattacagcg ggttcaaaat ccggtttaag 12121 aaccgctgtg tccgttcttc ttttggtgcg gagaaaattt gctccggcgg tccttgctcc 12181 acgataacgc cgccgtcgat gaagatgact tcatccgcaa cctcctgcgc gaacttgatt 12241 tcgtgggtca cgacgaccat ggtccagcct tcattggcca agtccttgat aaccttcagc 12301 acctctccga caagctcggg atcaagcgct gaggtcggtt cgtcaaacag catgagctca 12361 ggctgaatcg ccagtgcgcg ggcgatgccg acgcgctgct gctggccgcc ggaaagctgg 12421 aacggatata aatccatttt gtccttcaat ccgactttat caagaagctg aatcgcttct 12481 tttctgactt cctctttgtt ccgtttttgc acctgaatag ggccctccat cacgttttcg 12541 agggctgtgc ggtgcgggaa caggtgatac gcctgaaaca ccattccgga ttttcggcga 12601 agctttagga tatccgcctg tttcaccttt ttagagaaat cgatggagaa atcatcaaat 12661 gcaagctctc cgcgattcgg gatctccaga gcgttcaggc agcgaagcag cgtcgttttc 12721 cctgaacctg aaggcccaag tatggcgatg acttttcctt tttcaatctt catatctatc 12781 ttttttaaaa tttcattttc accgaatgat ttgtttaatc ctttaacggt aagcatactc 12841 ggaacctcct tatttggcca cgtagcggtc aagacgccgt tcgatgacat gctggacgag 12901 tgaaagcagg aagcagataa tccaataaat aaaggctgct tcaatataga tcactaaaat 12961 ttgatcaaga ttccgcgcgc cgatttcctg ggcttttctg aacagctcag cgaccagaat 13021 ttgagaggcg agggatgtat ctttaatcag gctgataaag gtattggata atggcgggat 13081 cgacacacga aacgcctgcg gcaaaatgac gcggaacagc gttttttgat gtgtcatgcc 13141 aattgtgtag ccggcttccc attgcccttt cggcacggat aaaatagatg cccgaatgat 13201 ttcagatgca taggcgccga cgtttaaaga aaaggcgata actgcgcttg gaaatggatc 13261 taatgtgacg ttaaaggccg ggaacagata gaaaatgatg aacaattgaa cgagaagagg 13321 agtgccgcgt attgcggata cgtatacgct gaacacccat ctcaaaggtc tcactttcga 13381 cattctggca agcgccgtaa tcagcgccag gatcattccg aatataaagg aaagaatcgt 13441 aaggggaatc gtatagtaga ttccccctga aagtatcggc cagaatgact gctgcaccag 13501 atcccacggg atcgccgtgc caagcgtcaa tgccggcaga ttatttagaa acatcttcgc 13561 cgaaccattt tttagaaatt ttagaaagag tcccgtcctc tttcatttct tttaatgctt 13621 tgttgacttg atcaacaacc tcgccgcttc ctttacggaa cgtgaaatat gttgactgag 13681 gatcacctgt ttcaaacgcg attttcacgt ttttattgcc agatgttttt aagtagttca 13741 atacggcaag cttatcgttg tatgtcatat cgacgcggcc ttgctggatc atttgaaggg 13801 cctgcgccat accttcaacg ccttctactt tagcgccggc atttgtagct aatttgttgt 13861 agttgcttgt cagtgattga gctgacgttt ttccttttac atctgcttca gacttaatat 13921 cgttgttgtc ttttttcgtt acgacaacgg ctcttgatgt tgtgtattta tctgagaaat 13981 catatttgtc ttcacgatct gtttttccga cttggttggc aacaacgtca aaccgtttgg 14041 aattcaggcc ggcaaacata ctgtcccact gtgtttcctt aaagtcgact ttaagcccga 14101 ggcgttttgc gacttctgtg ataacttcga catcatagcc agtcagttta tcagtgtctt 14161 tgtcgtggta agtgaacggc tcatatgttc cttccgttcc gactgtgagc acaccttttt 14221 tcttaattga agcccaaaga tcgccatctt tggcattatc ttttgactga ttgtcatttc 14281 ctgctccgca agctgcaaga gctgcaatac ttacgaccat gaataaagcc aataatgctt 14341 ttttcatctt attccccact tttctggttg attttattga aataaaaaaa tagcttacaa 14401 atctaaagga taactttttt ttagtatgag tcaagtaatt ggttttcata aggcaaaatc 14461 ttttaaaata aatccaaaaa ttgctgtgcc ggtttaggca aataactgtc cgttctccac 14521 atgacagccg gtgtcataat gaagggatta ttttcgatat ggacggtgtg aacgtgattt 14581 ctcatatgaa cgggaatcat tgtgacgggc aaaatagacg cgccgaatcc ggatgacacg 14641 aggctgagca aagttgcaga gtcgtggcat tcacaaacaa tgcgcggctc caggttcaaa 14701 cgatgaaatt cattcatgac ctgattatag acgccttttc cgttgacagg ccgcagcagg 14761 atcagcggaa atgaaggaat gtcctccatc ttaatggtgt ctccgcacgg atatccggct 14821 tcatctgaaa gcacgagcac acatggaatg tcatcaagct gcttgaattg tactgtgtca 14881 cttttgatca gtgttgtcgt gaccgccgca tcgatttgcc ggctttccag cagttccaac 14941 agtgtcgcgg gttcattttc ccaaatatta aaggtgagat gggggtatct ctctttgatc 15001 tgtgttactt tttcaagcat cagagccgcg caataaatcg ttgatcccac ggcaagtgtg 15061 ccggctactt cctccttcag ctcctgtacc tcaatgactg catcttcaaa cctatgcaga 15121 atctcttttg ctctttttag aaaaacagct ccttcatatg taagagtcat ttgttttttc 15181 ttgttacggt caaacaggac aacaccaagt tcgtcctcca gctgtttgag ctgcctgctt 15241 aaaggcggct gcgccatgtg aagctttttg gctgcggacg tgattttctg ttcttgggca 15301 atggtaatga agtatcgaag ctggcgaata tccaaaagaa agcgcctcct tatcatacct 15361 tttaggtatt aaatatagat ttaatagata tttttcatat ggatatatca ggagtatgat 15421 tgaaatgaaa gcagaattca agcgtaaagg agggggcaaa gtgaaactcg ttgtcggaat 15481 gacaggggca acaggggcca ttttcggggt caggctgctg cagtggctga aggccgccgg 15541 agtggaaacc catctcgttg tgtctccttg ggcaaacgtc acgatcaaac acgaaacagg 15601 ctatacctta caagaagtag aacaactggc cacatacact tactcacata aggatcaggc 15661 ggcagccatt tcaagcgggt cgtttgatac cgatggaatg attgttgcgc cgtgcagcat 15721 gaaatctctc gcaagcattc gcaccggaat ggcggataat ctgctgacac gtgcggcgga 15781 tgtcatgctc aaggagagaa aaaaactcgt cctcttaacg agagagacgc ctttgaacca 15841 aatacatctc gaaaatatgc tagcgcttac gaaaatgggc accatcattc ttcctccgat 15901 gccggcattt tataatcagc cgagcagctt agaggaaatg gttgaccata ttgtattcag 15961 aacgttggac caattcggca ttcggcttcc tgaagcgaag cgctggaatg ggattgaaaa 16021 acaaaaagga ggagcttgat catggcttat caagatttca gagaatttct cgctgccctt 16081 gaaaaagaag gacagctgct tacagtgaat gaagaggtaa agccggaacc ggatttaggg 16141 gccgccgcac gggcagccag caatcttggc gataaaagtc ccgcgctctt atttaacaac 16201 atttacggct atcataacgc gcgaattgcg atgaatgtta tcggctcttg gccaaaccat 16261 gcaatgatgc tgggcatgcc gaaagacaca ccggtaaaag aacagttttt tgaattcgca 16321 aagcgttatg accaatttcc gatgcctgtc aaacgtgagg aaacagcgcc atttcatgaa 16381 aatgaaatca cagaagatat caatttgttc gatatactgc ctcttttcag aataaaccaa 16441 ggagacggag gctactatct agacaaagcg tgtgttattt cccgtgatct tgaggaccct 16501 gacaacttcg gcaaacaaaa tgttggcatt tacagaatgc aagtcaaagg aaaagaccgc 16561 cttggcattc agcctgtccc gcagcacgat attgcaatcc atctgcgcca agctgaagaa 16621 cgcggcatca atcttccggt caccattgcg ctcggctgtg agccggtcat tacaacggcg 16681 gcatcgactc cgcttctcta tgatcaatca gaatacgaaa tggcaggcgc tattcaaggc 16741 gaaccatatc gcatcgtcaa atcaaagctg tctgatcttg atgttccgtg gggtgctgaa 16801 gtggtgcttg aaggtgagat tattgccgga gagcgcgaat atgaagggcc gtttggtgaa 16861 ttcacaggcc attattccgg cggacgcagc atgccgatta tcaaaattaa acgcgtctat 16921 cacagaaaca atccgatctt tgaacattta tacttaggca tgccttggac agaatgcgat 16981 tacatgatcg gcattaacac atgcgtgccg ctttatcagc agttaaaaga agcgtatccg 17041 aacgaaattg tggcagtgaa cgccatgtac acacacggtt taatcgcgat tgtttccaca 17101 aaaacccgct atggcggatt tgcgaaagcg gtcggcatgc gcgcactcac aacgccgcac 17161 ggactcggct actgcaaaat ggtcattgtc gttgatgagg atgtcgatcc attcaacctt 17221 ccgcaggtca tgtgggcgct ttcgaccaaa atgcatccga aacacgatgc ggtcatcatt 17281 ccggacttat ctgtcctgcc gcttgatccg ggatccaatc catcaggaat cactcacaaa 17341 atgattctcg acgccactac accggttgcg ccggaaacaa gaggccatta ttcacagccg 17401 cttgattctc cgctaacaac gaaagaatgg gaacaaaaac taatggactt aatgaataaa 17461 taaggaaagg atgttcgaaa tgcatacatg tcctcgatgc gactcaaaaa agggagaagt 17521 catgagcaaa tcgcctgtag aaggcgcatg ggaagtttat cagtgccaaa catgcttttt 17581 tacatggaga tcctgtgaac cggaaagcat tacaaatccc gaaaaataca atccagcgtt 17641 taaaattgat ccaaaggaaa cagaaacagc aattgaagtt ccggcggtgc cggaacgaaa 17701 ggcttgatcc gcgtgaactg tatgtcagac cgtctctttg agctgcttga cgggagctgc 17761 ctgaatgaga agcagcatga ggccttcgtt ctgcaaacag tatcagagga tggctggccg 17821 catgccgcta tgatcagtgc aggtgaaatc atcgcgctga gccgaactga tatccgaatc 17881 gctctgtgga aaaacacaat gacttcggcc aacatccttc gcacaggaaa agcacagttc 17941 acggcgtggt ggaagggagc ggcctattat gtaaagcttg aatgcgcgcc tttaccgcct 18001 ttgaaagatg ccgaatatga aagagaccgt ttttcctgcc gcatcgtttc agtgaaggag 18061 gacgttgcga aatacgctga tttgacttca ggtgtccgta tacagcttca cagcgctgaa 18121 gaggtgctga gcagatggga aaagaccctg gaagatttaa agcggtaata tcgatagcct 18181 gacgccatgc gtcaggcttt ttttatataa tgaaaacaaa gggggcgtga gaaatggaac 18241 gtgcggggat ctgtcactcg gacggctttg atttagctta tcgaattgag ggcgagggcg 18301 cacccatcct tgtgatcggg agtgcggttt actatccgcg ccttttttcc ccagatatca 18361 aacagaaata tcaatgggtc tttatcgacc ataggggatt tgctaagcct aagcgagggc 18421 ttcgtgcgga ggattcgagg cttgatgccg tcttggctga tatcgaaagg atgagaacat 18481 ttcttcagct tgaggatgtt actatcctgg gacattccgg gcacgctttt atggctttag 18541 agtatgccag gacatatccc aaacaagttc ggaaggtggc gctcttcaat actgcgcctg 18601 ataacagtga agaaagacag cgaaaaagcg aatcattttt catggaaaca gccagccttg 18661 agagaaagaa acgctttgaa aaagacatcg cgaatttgca gcaggacatc gacaaagatc 18721 ctgaaaggcg ctttgtgcac atgtgtattc gcgctgaagc gaaaagcttt tatcaagagc 18781 ggccgcatgc agctgcctta tgggatggcg tattcacgaa tatgccgatc attgatgaat 18841 tatggggcaa tacatttgcc cggattgatc ttattcagcg gttagctgat gttcgtatgc 18901 cggtgtatat tggattaggg agatatgatt atttggttgc gcccgttgcg ctatgggatg 18961 cagttgactg tttatatccc catgttgata aggttatttt tgaaaagagc ggccatcagc 19021 cgatgctgga agaaccggaa gcctttgatc aaagcttcag gaaatggctt gatcaataaa 19081 aaacagcccg cagatcaaca tctgcgggct gtttctgatt ataagacccc tttcatcgcg 19141 cgtttgatca tcggcgagag cagcaggaga atgccgccaa gaacgataga aatcaaaccg 19201 atggtgccga agtacattgt ttcaggaatt ttatcaaaca atccggctac ttgggcattg 19261 atcgcttggg ctgctgcgtt cgtcagaaac cacatactca ttgtctgtgc agagaaggca 19321 gctggtgcca gtttcgttgt cacggataaa ccgactggag acaggcacag ctctccaagc 19381 acgacaagca ggaagctgag aacgagccaa agcgggctta cgagtgcttc ttttccttgc 19441 atagcaggga ataccataat gataaatgac aatccggcca aaataattcc gattgagaat 19501 ttaactggtg tagacggctg gcgtttgcca agcttcatcc agagccatgc gaatattggt 19561 gcaaaaatga cgacaaacaa tggatttaat gattggaacc atgatgactg aagttcgaat 19621 ccgcccaatg aaagtcttat tcgttcatca gcgtataccg caagaatggt cgctccctgt 19681 tcctgaatgg cccagaacat gacagcaccg ataaacaaag gaatgtaagc ggcaagacgg 19741 gatttttctg tgctgtccgc ttttttgctt gtaaacatga tgatgaaata aatgacagga 19801 atcaaaatac cgagaatact tacaaggtcg ataaaacgat tgatcgtcag cacgcctgtt 19861 tgtacagaga tcatcactgc gatcgccacg atgataacac cgattccggt gccaatcgca 19921 gattttttag acagcggatt cggcacattg gaacctgcaa gcccgaggtt tttctttctt 19981 gtcaaagcaa aaacgataag tccgagaagc attccgaccg cggcagctcc gaagccgaga 20041 tgatagttgt acttctgtcc gagtgttccg acaattaacg gcgcaagtaa accaccgagg 20101 ttaatcccca tgtagaaaat actgaaacct gagtcgcggc gcgggtcttc tttcgtgtaa 20161 agatccccaa ccacgcttga aacgtttggt tttaataagc ctgttccgac aataataagc 20221 accatgctga tatagaatgc gatcgcgctg cccggatagg cgagtgcaat gtggccgaac 20281 ataatgaata tgccgccgta aaacacggtg tttgcggtac cgaatacccg gtcagcgagc 20341 catccgccaa taatggtgga catgtatacg agtgatccgt aaatcgacat aatggcaacc 20401 gcagtgccct tgtcaaagcc gagccctccg tttaccgtct ctgtatacaa atagtaaagt 20461 aagattgctc tcattccata gtaagagaaa cgctcccaaa attcggtgaa aaatagtgta 20521 aatagtcctc gcgggtgacc aaagaaccct ttttgcggga cgcttttaat gatactttcg 20581 ttatcaatcg aagccatgtc agccaaaccc tttctaaaaa aagtgtatta taaaaatcat 20641 attcttatat aatacttgtg tcaatataat ttatactcat ttcaaatagt tccataatgg 20701 aaaaattata aatacctaaa aatagtgatt ttctcctaat ttttatactc tttatcgtga 20761 gattttctta cacaactatt cctttatatt tttttaataa aattttagag aaatgtacaa 20821 gcagatcggg cctttgtgag taacatgata gtaatcatag agaaggaggc tcgcaattgg 20881 ctgaattcat attaaatgca gcggatttcg gtgttcctgg agatggtaaa acggattcga 20941 cagaacggat taatcagtgc ctcagtacag ctgtttcgaa aggctatcat actgtctggt 21001 ttccaaaggg aacatattta atagacgcaa cgcttggcgg agatcttaat cagaagtttc 21061 gaaacgcggg gatcattgtt cccggcaacc ttgagattat gatggacccc gaatgtatca 21121 tgaaagtgat accgaatagt tcgtggggtt attccgcatt ttatgtaggc aagcaagaga 21181 atataaccat ttccggggga caaattatcg gcgaacggga tgagcatacg tatgcctcgg 21241 cagggataag gtcaacccat gaatggggct ttggcatatg tattgaagga tgctcgaatg 21301 ttgtcattga tgatgtgaaa atttccgatt ttaccggcga tgggatcata gtcagcccaa 21361 ggggattaaa gaccaatcaa gattatcgaa cgtcagagca aattatcatc cgccgctgtg 21421 aggttcggcg gtcgaggaga aataacattt ccattaccgg atgtgacatg gtcacggtgg 21481 aggaatgctt gattgaagat gccggaacgg ggaatggaac agcgccgaaa ttcggaattg 21541 acattgaagg atatggcgaa ggtgatgttg attatgagga accgattaat gtatcaattc 21601 gcaataacca ctttgttgga aacgtttcaa gttctgtgac caattttaac gggtatggca 21661 ttttaataga aggaaatcac tcagacaata caatcagcta cggatatggg acgcaaacag 21721 tgatcaaggg aaatatactg aggcgccctg aagacgcggc ggctgcgcca agagtcggga 21781 taaccggact cggtgtatca caaggaaaag agaccagtga tgcagtgatc gctggcaacc 21841 tcattaccgg attttcaaca ggaattgatg tcaggggaaa gagcgttctt gtgacgaaca 21901 acaaaatcag caactttgaa aatacaggga tattggttta tcagtcctcc gacgtaaagg 21961 tagacggaaa ccaaattcaa aacggactgt ctgaaacaag gcgcagcatc ggtcttcgtg 22021 cagtgctttc agatgacacc gcttttctga ataactgtct cattcaagtc gttgacggtg 22081 tgagcgtttc gggcggaaac atgatcatta aagataatct cctgagaaaa ttcagccgag 22141 gcatttggat tgctcaaggg aacgcggtga ttgaagggaa tacactgaat cctggcgcgt 22201 ttgaagcagt gccggaatca tattctgttt ccgttacaaa caatgccggc gctatcatca 22261 aaaacaatac atttaaagag tttaaaaatt accccattta ctgctccaca agtgcaaaaa 22321 cctcaattat cggcaaccac ttagagagat ctccgctttt ggtcaccatc tatatcagcg 22381 ccggtgtgca tgagattttt gataatacca tttcagtcaa cagaacagct gggaatccga 22441 ttgtgattta tctcaatggc tctgcaggct ctatcatctc aggaaacacc atcaataacc 22501 tctccgcggg cactgcgaca gctattcaaa caaacacgtc aaccaattcc aaaatcatcg 22561 gcaaccgcat ttttaaaggg actatcaaca aacacagcag tgatgcaata gacggcaata 22621 ttatcgtctg aaaaaagcgc cccctctagg ggttcttttt tttcgattta tagatcacgt 22681 acatttctct cacaagtact aacacaaaaa ataaaagcac gacccattcc gcaaatgttg 22741 tcatcttaaa gctggacata ttgttataaa tggcttttgt taaactgaac ccttgaagca 22801 tgtccatcaa tacagaaata gctaataaac aaattaatat aactcctgtc acgcccaata 22861 tcttcatgct tcatcatcct ccgcttttag tgtctatcgt tggcggagaa gttataccgc 22921 atctaaacct aatgcataat ctcaatttta aaaggaagaa tatgagaaaa cgacaaggaa 22981 aggtatttgt gtatgccttt attttctaag cgaaagaaca atacaagttc gaaagacaag 23041 cgcaatacag aagaaaagaa tcaggaacag aagcaagaaa aagaaaggcc ggttctcatt 23101 tctccaagtt tggcaaagaa tatagcggaa acgaaaaagg aagtcggaag cagctctgac 23161 gtcatcattc gcgagattaa aatcggggag caggatcatg tccacctagc tgttatctat 23221 attgctgggc tggtcgataa taacacgatc catgagtcgt taattgaccc attggtacag 23281 gatgagtcta tccagaatac tcatgcgatc cagcaaattc ttgaaaaaac gctcccgctg 23341 ggcggggtga aagcggaaaa gagctgggac aagctttttt ccgagttaat gcttggcaat 23401 gcgctcattt ttgctgatgg ctatgatgaa gctttgattt gcagcactca agggggagag 23461 cagcgctcca tccaagagcc gagcacccag gtgtcattcc gcggcccgcg ccaagggttt 23521 acagagtctc tgcaaaccaa tatttccatg atccggcgat acattaaaaa tcagaattta 23581 tgggttgaaa aaatgaaaaa aggttctgtt acgaatacgg atatcgccct catgtacatt 23641 caaggaatat gtgatgaaaa ggtgctgaag gaagtgaagc agcgcctgga aaaaatagat 23701 attgacagta ttttggaatc tggatatatt gagcagctga ttgaagatga aacctttacg 23761 acgtttccga ctatgtatca tacagaacgc cctgatgttg tagcgggaaa tctgttagaa 23821 ggaagattcg cgattattgt ggacggaaca ccgtttgtgc ttattgcccc ggccttattt 23881 gtccaatttt ttcagtctgt tgaggattat tattcgcgtt ttgacattgc gacaagcata 23941 cggattcttc gtgttctagt ctttttcatt tcgcttgtgg caccagctgt atacgtggca 24001 gccacgacgt ttcatcaaga aatgataccg actcagctgt tagtggtcat tgcggcccag 24061 cgggagattg tcccgtttcc agctgttgtg gaggcgctga cgatggaggt tgcttttgag 24121 attctgaggg aagcgggagt caggctgccc cgggttgtcg gctcggcagt gtcaatcgta 24181 ggcgcgctcg taatcggcca ggctgccgta caggctggta tcgtctctcc ggcaatggtc 24241 attatcgtgg cactcaccgc gattgcgagt ttcgcaacac cggcgtttgc aatggcgatt 24301 tcagcccggc ttattcggtt tatttttatt attgcctcag ctgttatggg tttttacggg 24361 ctgattttag ggatcattat gatgtttgtc cacttatgca gtcttcgttc attcggcgtt 24421 ccatatatgt cgccgcttgc acccttttct tcacaaggtg taaaggacgc gcttttccgg 24481 attccgtggt gggctgatga aaaaaggccg gaatcgatca gtaaggaaga taaggtgcgg 24541 caggggaagg atcaacgccc agagccggcc gcttcacgag gaatggtgaa caaagacttg 24601 gaagaagggg atcagaatgg tacgtaaatg tctattagcc gttcttatgc ttttgagcgt 24661 cattgtgctg cccggctgct gggataagcg tgaactgaca gatcttgcga ttatctcggc 24721 gattggcatc gatcggacaa acgaaggcaa ctacgtgctg catcttcaaa ttatcaatcc 24781 tggaaatgtc gccggcgggc ttcagggagg cggtgctggg gacaggccgc ctgtatctgt 24841 ctattcaatt gaaggcgaca atttgacgga agcactcaga aaagcctcca tgaaggtatc 24901 gcggcggctt tattttgccc ataccaacct agtcgtaatc agcgaaaagc tggcgaaaga 24961 ggaagggctg gattttgtat tagacaatct tgaccgggac acggaattca ggacaacggc 25021 gaccttcgtc gttgcccata aaacaaaagc agaaaacatc gtgaaaatcc taacgcctat 25081 tgataaaatt ccgtcaaata aagtcaataa aaccctcgat ttcacggagg cgcaatacgg 25141 tcgggtggtc aaaaccaata ttcaggacgt tttgaaaaca cttgccagcg acacaagggc 25201 accgattatt ccgggttatt tgatgattgg cgatgataaa aaagg //