GCA_001286945.1 - 25 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

gnlProkkaPLCCKAFL_4 (original name was: gnl|Prokka|PLCCKAFL_4)

Region	Type	From	To	Most similar known cluster		Similarity
Region 4.1	NRP-metallophore,NRPS,RiPP-like	45,347	92,942	bacillibactin	NRP	100%

gnlProkkaPLCCKAFL_7 (original name was: gnl|Prokka|PLCCKAFL_7)

Region	Type	From	To	Most similar known cluster		Similarity
Region 7.1	lanthipeptide-class-ii	71,224	94,412	mersacidin	RiPP:Lanthipeptide	100%

gnlProkkaPLCCKAFL_13 (original name was: gnl|Prokka|PLCCKAFL_13)

Region	Type	From	To	Most similar known cluster		Similarity
Region 13.1	other	102,618	144,036	bacilysin	Other	100%

gnlProkkaPLCCKAFL_16 (original name was: gnl|Prokka|PLCCKAFL_16)

Region	Type	From	To	Most similar known cluster		Similarity
Region 16.1	transAT-PKS,NRPS,T3PKS	1	44,033	bacillaene	Polyketide+NRP	71%

gnlProkkaPLCCKAFL_21 (original name was: gnl|Prokka|PLCCKAFL_21)

Region	Type	From	To	Most similar known cluster		Similarity
Region 21.1	terpene	90,597	111,337

gnlProkkaPLCCKAFL_22 (original name was: gnl|Prokka|PLCCKAFL_22)

Region	Type	From	To	Most similar known cluster		Similarity
Region 22.1	T3PKS	105,201	142,342

gnlProkkaPLCCKAFL_23 (original name was: gnl|Prokka|PLCCKAFL_23)

Region	Type	From	To	Most similar known cluster		Similarity
Region 23.1	NRPS	3,804	26,237	locillomycin/locillomycin B/locillomycin C	NRP+Polyketide	28%

gnlProkkaPLCCKAFL_27 (original name was: gnl|Prokka|PLCCKAFL_27)

Region	Type	From	To	Most similar known cluster		Similarity
Region 27.1	phosphonate	39,329	51,470

gnlProkkaPLCCKAFL_28 (original name was: gnl|Prokka|PLCCKAFL_28)

Region	Type	From	To	Most similar known cluster		Similarity
Region 28.1	NRPS	1	25,496	surfactin	NRP:Lipopeptide	39%

gnlProkkaPLCCKAFL_42 (original name was: gnl|Prokka|PLCCKAFL_42)

Region	Type	From	To	Most similar known cluster		Similarity
Region 42.1	NRPS,transAT-PKS	1	33,842

gnlProkkaPLCCKAFL_44 (original name was: gnl|Prokka|PLCCKAFL_44)

Region	Type	From	To	Most similar known cluster		Similarity
Region 44.1	transAT-PKS	25,110	93,588	macrolactin H	Polyketide	100%

gnlProkkaPLCCKAFL_45 (original name was: gnl|Prokka|PLCCKAFL_45)

Region	Type	From	To	Most similar known cluster		Similarity
Region 45.1	NRPS	91,436	119,099	surfactin	NRP:Lipopeptide	47%

gnlProkkaPLCCKAFL_50 (original name was: gnl|Prokka|PLCCKAFL_50)

Region	Type	From	To	Most similar known cluster		Similarity
Region 49.1	PKS-like	1	36,333	butirosin A/butirosin B	Saccharide	7%

gnlProkkaPLCCKAFL_53 (original name was: gnl|Prokka|PLCCKAFL_53)

Region	Type	From	To	Most similar known cluster		Similarity
Region 51.1	NRPS,transAT-PKS,betalactone	1,661	89,335	fengycin	NRP	73%

gnlProkkaPLCCKAFL_56 (original name was: gnl|Prokka|PLCCKAFL_56)

Region	Type	From	To	Most similar known cluster		Similarity
Region 53.1	transAT-PKS-like	1	22,869	difficidin	Polyketide	26%

gnlProkkaPLCCKAFL_58 (original name was: gnl|Prokka|PLCCKAFL_58)

Region	Type	From	To	Most similar known cluster		Similarity
Region 55.1	NRPS	1	9,286	surfactin	NRP:Lipopeptide	8%

gnlProkkaPLCCKAFL_60 (original name was: gnl|Prokka|PLCCKAFL_60)

Region	Type	From	To	Most similar known cluster		Similarity
Region 56.1	NRPS	1	3,089

gnlProkkaPLCCKAFL_64 (original name was: gnl|Prokka|PLCCKAFL_64)

Region	Type	From	To	Most similar known cluster		Similarity
Region 59.1	transAT-PKS-like	1	45,659	difficidin	Polyketide	53%

gnlProkkaPLCCKAFL_68 (original name was: gnl|Prokka|PLCCKAFL_68)

Region	Type	From	To	Most similar known cluster		Similarity
Region 63.1	transAT-PKS-like	1	5,709

gnlProkkaPLCCKAFL_81 (original name was: gnl|Prokka|PLCCKAFL_81)

Region	Type	From	To	Most similar known cluster		Similarity
Region 71.1	terpene	1	14,769

gnlProkkaPLCCKAFL_89 (original name was: gnl|Prokka|PLCCKAFL_89)

Region	Type	From	To	Most similar known cluster		Similarity
Region 76.1	transAT-PKS-like,NRPS	24,594	75,518	bacillaene	Polyketide+NRP	28%

gnlProkkaPLCCKAFL_102 (original name was: gnl|Prokka|PLCCKAFL_102)

Region	Type	From	To	Most similar known cluster		Similarity
Region 86.1	NRPS	1	6,646

gnlProkkaPLCCKAFL_110 (original name was: gnl|Prokka|PLCCKAFL_110)

Region	Type	From	To	Most similar known cluster		Similarity
Region 91.1	transAT-PKS	1	10,886	difficidin	Polyketide	40%

gnlProkkaPLCCKAFL_123 (original name was: gnl|Prokka|PLCCKAFL_123)

Region	Type	From	To	Most similar known cluster		Similarity
Region 96.1	NRPS	1	13,051	fengycin	NRP	20%

gnlProkkaPLCCKAFL_128 (original name was: gnl|Prokka|PLCCKAFL_128)

Region	Type	From	To	Most similar known cluster		Similarity
Region 98.1	NRPS	1	9,307	fengycin	NRP	13%

Compact view

gnlProkkaPLCCKAFL_4 - Region 1 - NRP-metallophore,NRPS,RiPP-like

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Location: 45,347 - 92,942 nt. (total: 47,596 nt) Show pHMM detection rules used

Region on contig edge.

NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX))
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

Gene overview

NRPS/PKS domains

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Detailed domain annotation

Selected features only

Show module domains

Similar known gene clusters from MIBiG 3.1

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 45346 - 92942:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg4_69

Search NORINE for peptide: strict or relaxed

AMP-binding (456..855): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: DILQLGLIWK
Nearest Stachelhaus code(s):: Gly DILQLGLIWK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1513..1929): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: DFWNIGMVHK
Nearest Stachelhaus code(s):: Thr DFWNIGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

ctg4_71

Search NORINE for peptide: strict or relaxed

AMP-binding (31..435): diOH-Bz

nrpys: diOH-Bz

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Small clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Single AA prediction:: dhb (diOH-Bz)

Stachelhaus prediction details:

Stachelhaus sequence:: PLPAQGVVNK
Nearest Stachelhaus code(s):: diOH-Bz PLPAQGVVNK (100% 8Å match); diOH-Bz or Sal PLPAQGVVNK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

gnlProkkaPLCCKAFL_7 - Region 1 - lanthipeptide-class-ii

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Location: 71,224 - 94,412 nt. (total: 23,189 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

KnownClusterBlast

Lanthipeptides

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

Lanthipeptide predictions

Lanthipeptide(s) for ctg7_73

ctg7_76

Leader:

MSQEAIIRSWKDPFSRENSTQNPAGNPFSELKEAQMDKLVGA

Core:

GDMEAACTFTLPGGGGVCTLTSECIC

Core with dehydrations:

GDMEAACysDhbFDhbLPGGGGVCysDhbLDhbDhaECysICys

MIBiG 3.1 matches for ctg7_76

30.0% BGC0002110 (QKV49893.1): Lanthipeptide: birimositide

11

LPGGGGVCTLTSEC

24

L GG CTLT EC

12

LGNNGGWCTLTKEC

25

28.6% BGC0000517 (BAB04173.1): Lanthipeptide: haloduracin β or haloduracin α

11

LPGGGGVCTLTSECI

25

L G CTLT EC+

10

LGNKGAYCTLTVECM

24

12.8% BGC0001229 (SBI_06990): Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

18

CTLTSEC

24

CTL+ EC

28

CTLSKEC

34

antiSMASH-DB 4.0 matches for ctg7_76

100.0% NC_017912.1and 14 others:

NZ_CP007242.1 Lanthipeptides: KHU1_RS17410_lanthipeptideNZ_CP031424.1 Lanthipeptides: DXX91_RS18935_lanthipeptideNZ_CP032855.1 Lanthipeptides: D9C11_RS10440_lanthipeptideNZ_CP043809.1 Lanthipeptides: ETZ92_RS14260_lanthipeptideNZ_CP049904.1 Lanthipeptides: V753_RS18470_lanthipeptideNZ_CP053764.1 Lanthipeptides: HPQ66_RS18325_lanthipeptideNZ_CP061938.1 Lanthipeptides: IEN91_RS19800_lanthipeptideNZ_CP063768.1 Lanthipeptides: IM712_RS05205_lanthipeptideNZ_CP087137.1 Lanthipeptides: LOK79_RS18580_lanthipeptideNZ_CP092383.1 Lanthipeptides: MID02_RS19390_lanthipeptideNZ_JAEACM010000001.1 Lanthipeptides: I5F15_RS04355_lanthipeptideNZ_JAJNPN010000015.1 Lanthipeptides: LQ568_RS13285_lanthipeptideNZ_SDKF01000002.1 Lanthipeptides: EUA41_RS09950_lanthipeptideNZ_VDUT01000007.1 Lanthipeptides: FS412_RS14545_lanthipeptide

Lanthipeptides: MUS_RS20065_lanthipeptide

1

GDMEAACTFTLPGGGGVCTLTSECIC

26

GDMEAACTFTLPGGGGVCTLTSECIC

1

GDMEAACTFTLPGGGGVCTLTSECIC

26

96.2% NZ_BORO01000007.1: Lanthipeptides: KI343_RS07745_lanthipeptide

1

GDMEAACTFTLPGGGGVCTLTSECIC

26

GDMEAACT+TLPGGGGVCTLTSECIC

1

GDMEAACTWTLPGGGGVCTLTSECIC

26

92.3% NZ_JALASB010000016.1and 3 others:

NZ_JALASR010000012.1 Lanthipeptides: MOD87_RS16305_lanthipeptideNZ_JALAUW010000005.1 Lanthipeptides: MOE83_RS03160_lanthipeptideNZ_JALAXQ010000010.1 Lanthipeptides: MOF24_RS12150_lanthipeptide

Lanthipeptides: MOD42_RS18070_lanthipeptide

1

GDMEAACTFTLPGGGGVCTLTSECIC

26

GDMEAACT+TLPGGGGVCT+TSECIC

1

GDMEAACTWTLPGGGGVCTITSECIC

26

with 98 more sequence matches

92.3% NZ_KZ454939.1: Lanthipeptides: CEF20_RS01155_lanthipeptide

1

GDMEAACTFTLPGGGGVCTLTSECIC

26

GDMEAACT+TLPGGGGVCT+TSECIC

1

GDMEAACTWTLPGGGGVCTVTSECIC

26

40.0% NZ_CP047419.1and 3 others:

NZ_CP047419.1 Lanthipeptides: GTU71_RS12805_lanthipeptideNZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15590_lanthipeptideNZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15590_lanthipeptide

Lanthipeptides: GTU71_RS12805_lanthipeptide

8

TFTLPG----GGGVCTLTSEC

24

TFTL GG CTLT EC

5

TFTLSNVLGNQGGWCTLTVEC

25

40.0% NZ_CP084530.1and 1 other:

NZ_CP084530.1 Lanthipeptides: LDO05_RS02075_lanthipeptide

Lanthipeptides: LDO05_RS02075_lanthipeptide

8

TFTLPG----GGGVCTLTSEC

24

TFTL GG CTLT EC

5

TFTLSNYLGNNGGWCTLTKEC

25

40.0% NZ_LT985747.1and 1 other:

NZ_LT985747.1 Lanthipeptides: C8268_RS00165_lanthipeptide

Lanthipeptides: C8268_RS00165_lanthipeptide

8

TFTLP----GGGGVCTLTSEC

24

TFTL GG CTLT EC

5

TFTLSDYLGNKGGWCTLTKEC

25

39.3% NZ_FOBE01000018.1: Lanthipeptides: BMW61_RS13085_lanthipeptide

2

DMEAACTFTLPGGGGVCTLTSEC

24

+M AA L G CTLT EC

5

EMSAA----LGNRGSYCTLTKEC

23

36.7% NZ_MJEJ02000054.1and 3 others:

NZ_MJEJ02000054.1 Lanthipeptides: BH683_RS28205_lanthipeptideNZ_QJSP01000005.1 Lanthipeptides: DFR67_RS09500_lanthipeptideNZ_QJSP01000005.1 Lanthipeptides: DFR67_RS09500_lanthipeptide

Lanthipeptides: BH683_RS28205_lanthipeptide

8

TFTLP----GGGGVCTLTSE

23

TFTL GG CTLT E

5

TFTLSDFLGNDGGWCTLTKE

24

35.3% NZ_SDLS01000001.1: Lanthipeptides: EIZ45_RS45960_lanthipeptide

2

DMEAACTFTLPGGGGVCTLTSECIC

26

D+ A T LP G +CT T EC C

10

DLAEARTAALPSSGYICTFTFECNC

34

34.6% NZ_CP034669.1: Lanthipeptides: EJ065_RS32040_lanthipeptide

15

GGVCTLTSECIC

26

G VCTLT+EC C

11

GYVCTLTTECGC

22

34.6% NZ_CP035495.1and 1 other:

NZ_CP035495.1 Lanthipeptides: ET495_RS17535_lanthipeptide

Lanthipeptides: ET495_RS17535_lanthipeptide

9

FTLPGG---GGVCTLTSEC

24

+T+PG G CTL+ EC

2

WTIPGTSTIGRFCTLSWEC

20

34.6% NZ_JALMDK010000017.1: Lanthipeptides: allorf_059288_059443_lanthipeptide

14

GGGVCTLTSECIC

26

GG +CTLT EC C

3

GGYICTLTWECNC

15

33.3% NZ_BLIS01000009.1and 7 others:

NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04820_lanthipeptideNZ_LR134317.1 Lanthipeptides: EL136_RS01685_lanthipeptideNZ_LR134317.1 Lanthipeptides: EL136_RS01685_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02620_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02620_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01935_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01935_lanthipeptide

Lanthipeptides: GVO03_RS04820_lanthipeptide

8

TFTLP----GGGGVCTLTSECI

25

TF+L G CTLT EC+

5

TFSLSDYWGNKGNWCTLTHECM

26

33.3% NZ_CP027862.1and 1 other:

NZ_CP027862.1 Lanthipeptides: allorf_0097945_0098112_lanthipeptide

Lanthipeptides: allorf_0097945_0098112_lanthipeptide

8

TFTLP----GGGGVCTLTSECI

25

TF+L G CTLT EC+

5

TFSLSDYWGNRGYWCTLTHECM

26

33.3% NZ_CP061868.1and 1 other:

NZ_CP061868.1 Lanthipeptides: IE339_RS06330_lanthipeptide

Lanthipeptides: IE339_RS06330_lanthipeptide

8

TFTLP----GGGGVCTLTSECI

25

TF+L GG CT T EC+

5

TFSLSDYWGNKGGWCTATHECM

26

33.3% NZ_GG657757.1and 1 other:

NZ_GG657757.1 Lanthipeptides: SSQG_RS20730_lanthipeptide

Lanthipeptides: SSQG_RS20730_lanthipeptide

8

TFTLPG----GGGVCTLTSEC

24

TF+L G G CTLT EC

8

TFSLSGIFGNDGDCCTLTKEC

28

33.3% NZ_JAJAGO010000028.1and 1 other:

NZ_JAJAGO010000028.1 Lanthipeptides: LHJ74_RS33590_lanthipeptide

Lanthipeptides: LHJ74_RS33590_lanthipeptide

8

TFTLPGGGG----VCTLTSEC

24

TF+L G CTLT EC

5

TFSLSDAAGNDGWWCTLTKEC

25

32.3% NZ_PVMZ01000043.1and 1 other:

NZ_PVMZ01000043.1 Lanthipeptides: CLV67_RS49720_lanthipeptide

Lanthipeptides: CLV67_RS49720_lanthipeptide

9

FTLPGG---GGVCTLTSEC

24

FT+PG G VCT + EC

2

FTVPGTSTIGYVCTYSYEC

20

32.1% NZ_LR134483.1and 1 other:

NZ_LR134483.1 Lanthipeptides: EL241_RS01725_lanthipeptide

Lanthipeptides: EL241_RS01725_lanthipeptide

10

TLPGGGGVCTLTSEC

24

+L G VCTLT EC

9

SLGNKGYVCTLTKEC

23

31.0% NZ_CP016767.1and 11 others:

NZ_CP016767.1 Lanthipeptides: BCV50_RS13410_lanthipeptideNZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15325_lanthipeptideNZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15325_lanthipeptideNZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07920_lanthipeptideNZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07920_lanthipeptideNZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00580_lanthipeptideNZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00580_lanthipeptideNZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17015_lanthipeptideNZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17015_lanthipeptideNZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04645_lanthipeptideNZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04645_lanthipeptide

Lanthipeptides: BCV50_RS13410_lanthipeptide

8

TFTLP----GGGGVCTLTSECI

25

TF+L GG CT++ EC+

5

TFSLSDYWGNKGGWCTVSKECM

26

31.0% NZ_LR027842.1: Lanthipeptides: E0E39_RS15855_lanthipeptide

9

FTLPGG---GGVCTLTSEC

24

+T+PG G VCT++ EC

2

WTVPGTRTIGAVCTVSWEC

20

31.0% NZ_NTSF01000026.1and 1 other:

NZ_NTSF01000026.1 Lanthipeptides: CN325_RS21835_lanthipeptide

Lanthipeptides: CN325_RS21835_lanthipeptide

11

LPGGGGVCTLTSEC

24

L G VCTLT EC

11

LGNDGSVCTLTKEC

24

30.8% NC_015760.1and 5 others:

NZ_CAJHJN010000010.1 Lanthipeptides: JMZ68_RS09030_lanthipeptideNZ_JACLQK010000036.1 Lanthipeptides: H7U04_RS11500_lanthipeptideNZ_JADPEB010000003.1 Lanthipeptides: I4U26_RS02800_lanthipeptideNZ_JAQCST010000021.1 Lanthipeptides: PGZ09_RS09470_lanthipeptideNZ_OU540596.1 Lanthipeptides: JQ838_RS05640_lanthipeptide

Lanthipeptides: SALIVB_RS03310_lanthipeptide

13

GGGGVCTLTSEC

24

G G V TLT EC

1

GNGVVLTLTHEC

12

30.8% NZ_CP036455.1and 4 others:

NZ_JAGPXN010000019.1 Lanthipeptides: KBX06_RS22045_lanthipeptideNZ_JAODUN010000003.1 Lanthipeptides: BXY51_RS10560_lanthipeptideNZ_KB895893.1 Lanthipeptides: C569_RS0129325_lanthipeptideNZ_KB900614.1 Lanthipeptides: SALPAC6_RS0114155_lanthipeptide

Lanthipeptides: EKD16_RS25235_lanthipeptide

13

GGGGVCTLTSEC

24

G VCTLT EC

1

SSGWVCTLTIEC

12

30.8% NZ_JACHJG010000002.1: Lanthipeptides: FHS38_RS07010_lanthipeptide

8

TFTLPGGGGVCTLTSECIC

26

+F P G VC + CIC

7

SFPTPITGRVCNPDTGCIC

25

30.8% NZ_LR134483.1and 1 other:

NZ_LR134483.1 Lanthipeptides: EL241_RS01720_lanthipeptide

Lanthipeptides: EL241_RS01720_lanthipeptide

10

TLPGGGGVCTLTSEC

24

L G +CTLT EC

7

NLGNKGRICTLTKEC

21

30.8% NZ_LT630004.1: Lanthipeptides: BQ5796_RS17475_lanthipeptide

11

LPGGGGVCTLTSECI

25

L G CTLT EC+

6

LGNDGKFCTLTVECM

20

30.0% NZ_AKXV01000031.1and 8 others:

NZ_AKXV01000031.1 Lanthipeptides: Y19_RS0109895_lanthipeptideNZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptideNZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptideNZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptideNZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptideNZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13545_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptide

Lanthipeptides: Y19_RS0109895_lanthipeptide

11

LPGGGGVCTLTSEC

24

L GG CTLT EC

12

LGNQGGWCTLTKEC

25

30.0% NZ_BJTV01000004.1and 7 others:

NZ_BJTV01000004.1 Lanthipeptides: TNCT1_RS10200_lanthipeptideNZ_CP016795.1 Lanthipeptides: BC342_RS18360_lanthipeptideNZ_CP016795.1 Lanthipeptides: BC342_RS18360_lanthipeptideNZ_CP036534.1 Lanthipeptides: EZV63_RS18960_lanthipeptideNZ_CP036534.1 Lanthipeptides: EZV63_RS18960_lanthipeptideNZ_CP094676.1 Lanthipeptides: L6J92_RS01495_lanthipeptideNZ_CP094676.1 Lanthipeptides: L6J92_RS01495_lanthipeptide

Lanthipeptides: TNCT1_RS10200_lanthipeptide

11

LPGGGGVCTLTSEC

24

L GG CTLT EC

12

LGNHGGWCTLTKEC

25

30.0% NZ_BMMP01000005.1and 3 others:

NZ_BMMP01000005.1 Lanthipeptides: IEY56_RS28370_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptide

Lanthipeptides: IEY56_RS28370_lanthipeptide

11

LPGGGGVCTLTSEC

24

L GG CTLT EC

12

LGNTGGWCTLTVEC

25

30.0% NZ_BNBV01000031.1and 1 other:

NZ_BNBV01000031.1 Lanthipeptides: IE286_RS22995_lanthipeptide

Lanthipeptides: IE286_RS22995_lanthipeptide

11

LPGGGGVCTLTSEC

24

L GG CTLT EC

12

LGNSGGWCTLTKEC

25

30.0% NZ_CACZYW010000004.1and 1 other:

NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02825_lanthipeptide

Lanthipeptides: HUF10_RS02825_lanthipeptide

8

TFTLP----GGGGVCTLTSECI

25

TF+L G CTL+ EC+

5

TFSLSDYWGNNGNWCTLSHECM

26

30.0% NZ_CP034414.1and 1 other:

NZ_CP034414.1 Lanthipeptides: EI692_RS18440_lanthipeptide

Lanthipeptides: EI692_RS18440_lanthipeptide

8

TFTLP----GGGGVCTLTSECI

25

TF+L GG CT++ EC+

5

TFSLSDYWGNKGGWCTISHECM

26

30.0% NZ_CP043317.1and 1 other:

NZ_CP043317.1 Lanthipeptides: FYC74_RS17680_lanthipeptide

Lanthipeptides: FYC74_RS17680_lanthipeptide

10

TLPGGGGVCTLTSEC

24

+L GG CTLT EC

11

SLGNHGGWCTLTKEC

25

30.0% NZ_CP051884.1and 2 others:

NZ_CP051884.1 Lanthipeptides: HGK68_RS15125_lanthipeptideNZ_CP051884.1 Lanthipeptides: HGK68_RS15125_lanthipeptide

Lanthipeptides: HGK68_RS15125_lanthipeptide

8

TFTLP----GGGGVCTLTSECI

25

TF+L G +CT+T EC+

5

TFSLSDYWGNNGWLCTITHECM

26

30.0% NZ_JAASAG010000001.1and 1 other:

NZ_JAASAG010000001.1 Lanthipeptides: HCC61_RS30395_lanthipeptide

Lanthipeptides: HCC61_RS30395_lanthipeptide

11

LPGGGGVCTLTSEC

24

L GG CTLT EC

12

LTNTGGWCTLTVEC

25

30.0% NZ_PCGR01000003.1and 1 other:

NZ_PCGR01000003.1 Lanthipeptides: CQS04_RS09620_lanthipeptide

Lanthipeptides: CQS04_RS09620_lanthipeptide

8

TFTLP----GGGGVCTLTSECI

25

TF+L G CT T EC+

5

TFSLSDYWGNNGNWCTATHECM

26

30.0% NZ_QGEE01000020.1and 5 others:

NZ_QGEE01000020.1 Lanthipeptides: DKP74_RS06160_lanthipeptideNZ_QGEF01000018.1 Lanthipeptides: DKP75_RS05595_lanthipeptideNZ_QGEF01000018.1 Lanthipeptides: DKP75_RS05595_lanthipeptideNZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05380_lanthipeptideNZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05380_lanthipeptide

Lanthipeptides: DKP74_RS06160_lanthipeptide

8

TFTLP----GGGGVCTLTSECI

25

TF+L G CTL+ EC+

5

TFSLSDYWGNRGNWCTLSHECM

26

30.0% NZ_QLLX01000002.1and 1 other:

NZ_QLLX01000002.1 Lanthipeptides: K378_RS05175_lanthipeptide

Lanthipeptides: K378_RS05175_lanthipeptide

11

LPGGGGVCTLTSEC

24

L GG CTLT EC

12

LTNQGGWCTLTVEC

25

29.6% NZ_CP022163.1: Lanthipeptides: MEBOL_RS24465_lanthipeptide

11

LPG--GGGVCTLTSEC

24

+PG GG +CT ++EC

7

VPGNSGGWICTYSTEC

22

29.6% NZ_CP025249.1and 1 other:

NZ_CP025249.1 Lanthipeptides: CWT12_RS00385_lanthipeptide

Lanthipeptides: CWT12_RS00385_lanthipeptide

15

GGVCTLTSEC

24

G VCTLT EC

13

GYVCTLTKEC

22

29.6% NZ_CP071875.1: Lanthipeptides: J4I02_RS02880_lanthipeptide

14

GGGVCTLTSEC

24

GG +CTLT EC

8

GGAICTLTHEC

18

29.6% NZ_CP114875.1: Lanthipeptides: O4Z47_RS14375_lanthipeptide

13

GGGGVCTLTSEC

24

G +CTLTSEC

7

SSGDICTLTSEC

18

29.4% NC_014643.1and 2 others:

NZ_KV795763.1 Lanthipeptides: HMPREF2554_RS11600_lanthipeptideNZ_KV804818.1 Lanthipeptides: HMPREF2804_RS11135_lanthipeptide

Lanthipeptides: HMPREF0733_RS11155_lanthipeptide

4

EAACTFTLPGG---GGVCTLTSEC

24

+A FT+PG G CT++ EC

4

QAGGLFTVPGTTTVGHFCTISWEC

27

29.0% NZ_GG657754.1and 1 other:

NZ_GG657754.1 Lanthipeptides: SSOG_RS49055_lanthipeptide

Lanthipeptides: SSOG_RS49055_lanthipeptide

1

GDMEAACTFTLPGGGGVCTLTSEC

24

G E +F + G CT T EC

3

GGAEYVVSFVMGNLGNFCTATLEC

26

28.6% NC_021362.1and 29 others:

NC_021362.1 Lanthipeptides: BALI_RS00925_lanthipeptideNZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptideNZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptideNZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptideNZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptideNZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptideNZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptideNZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptideNZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptideNZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptideNZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptideNZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptideNZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptideNZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptideNZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptideNZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptideNZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptideNZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptideNZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptideNZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptideNZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptideNZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptideNZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptideNZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptideNZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptideNZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptideNZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptideNZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptideNZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptide

Lanthipeptides: BALI_RS00925_lanthipeptide

11

LPGGGGVCTLTSEC

24

L G CTLT EC

10

LGNKGQWCTLTKEC

23

28.6% NZ_CP006058.1and 25 others:

NZ_CP006058.1 Lanthipeptides: BAMY6639_RS13800_lanthipeptideNZ_CP021892.1 Lanthipeptides: S100333_RS03315_lanthipeptideNZ_CP021892.1 Lanthipeptides: S100333_RS03315_lanthipeptideNZ_CP026533.1 Lanthipeptides: C3438_RS12905_lanthipeptideNZ_CP026533.1 Lanthipeptides: C3438_RS12905_lanthipeptideNZ_CP028961.1 Lanthipeptides: DBK22_RS18395_lanthipeptideNZ_CP028961.1 Lanthipeptides: DBK22_RS18395_lanthipeptideNZ_CP032855.1 Lanthipeptides: D9C11_RS14690_lanthipeptideNZ_CP032855.1 Lanthipeptides: D9C11_RS14690_lanthipeptideNZ_CP044132.1 Lanthipeptides: F5K02_RS03560_lanthipeptideNZ_CP044132.1 Lanthipeptides: F5K02_RS03560_lanthipeptideNZ_CP061087.1 Lanthipeptides: IAR44_RS03165_lanthipeptideNZ_CP061087.1 Lanthipeptides: IAR44_RS03165_lanthipeptideNZ_CP063276.1 Lanthipeptides: IM743_RS02795_lanthipeptideNZ_CP063276.1 Lanthipeptides: IM743_RS02795_lanthipeptideNZ_CP065791.1 Lanthipeptides: I8N73_RS03395_lanthipeptideNZ_CP065791.1 Lanthipeptides: I8N73_RS03395_lanthipeptideNZ_CP074348.1 Lanthipeptides: KHA74_RS03200_lanthipeptideNZ_CP074348.1 Lanthipeptides: KHA74_RS03200_lanthipeptideNZ_CP083943.1 Lanthipeptides: LCH16_RS03220_lanthipeptideNZ_CP083943.1 Lanthipeptides: LCH16_RS03220_lanthipeptideNZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10965_lanthipeptideNZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10965_lanthipeptideNZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15475_lanthipeptideNZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15475_lanthipeptide

Lanthipeptides: BAMY6639_RS13800_lanthipeptide

11

LPGGGGVCTLTSEC

24

L G CTLT EC

10

LGNKGAWCTLTVEC

23

28.1% NZ_CP015591.1and 19 others:

NZ_CP015591.1 Lanthipeptides: A7A70_RS27560_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29375_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29370_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29365_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29955_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29950_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29945_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29955_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29950_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29945_lanthipeptideNZ_JACYOF010000027.1 Lanthipeptides: IGI01_RS29005_lanthipeptideNZ_NUBO01000052.1 Lanthipeptides: CN575_RS29780_lanthipeptideNZ_NVJC01000007.1 Lanthipeptides: COM38_RS07400_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23035_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23030_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23025_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23035_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23030_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23025_lanthipeptide

Lanthipeptides: A7A70_RS27565_lanthipeptide

11

LPGGGGVCTLTSECI

25

L GG CTLT EC+

14

LGNNGGYCTLTKECM

28

28.1% NZ_CP051884.1and 2 others:

NZ_CP051884.1 Lanthipeptides: HGK68_RS15160_lanthipeptideNZ_CP051884.1 Lanthipeptides: HGK68_RS15160_lanthipeptide

Lanthipeptides: HGK68_RS15160_lanthipeptide

4

EAACTFTLPGG---GGVCTLTSEC

24

A +T+PG G CT++ EC

1

RAGGIWTIPGTKTIGAFCTISYEC

24

27.6% NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: EG886_RS06310_lanthipeptide

Lanthipeptides: EG886_RS06310_lanthipeptide

11

LPGGGGVCTLTSEC

24

L G CTLT EC

10

LGNTGQFCTLTKEC

23

27.6% NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: EG886_RS06305_lanthipeptide

Lanthipeptides: EG886_RS06305_lanthipeptide

11

LPGGGGVCTLTSEC

24

L G CTLT EC

10

LGNTGRFCTLTKEC

23

27.5% NZ_JALIRS010000003.1and 3 others:

NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07255_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptide

Lanthipeptides: MOK21_RS07255_lanthipeptide

5

AACTFTLPGGGGVCTLTSEC

24

AA ++ L G VCTLT EC

16

AAASYILGNPGHVCTLTVEC

35

26.9% NC_009480.1and 10 others:

NZ_CP033724.1 Lanthipeptides: EFE39_RS10220_lanthipeptideNZ_CP047051.1 Lanthipeptides: GRD74_RS10365_lanthipeptideNZ_CP047054.1 Lanthipeptides: GRD61_RS10460_lanthipeptideNZ_CP053860.1 Lanthipeptides: DQP62_RS10825_lanthipeptideNZ_CP076352.1 Lanthipeptides: KN218_RS09900_lanthipeptideNZ_CP085137.1 Lanthipeptides: LHJ48_RS10290_lanthipeptideNZ_CP085140.1 Lanthipeptides: LHJ47_RS10305_lanthipeptideNZ_CP095274.1 Lanthipeptides: MU580_RS10460_lanthipeptideNZ_PSTW01000024.1 Lanthipeptides: C5C03_RS09675_lanthipeptideNZ_SISU01000002.1 Lanthipeptides: EOG37_RS09890_lanthipeptide

Lanthipeptides: CMM_RS10575_lanthipeptide

12

PGGGGVCTLTSEC

24

G +CTLT EC

1

SSSGWLCTLTIEC

13

26.9% NZ_BMEX01000022.1: Lanthipeptides: IEV46_RS16225_lanthipeptide

13

GGGGVCTLTSEC

24

G G VCT T +C

2

GCGNVCTWTKDC

13

26.9% NZ_BMMB01000007.1and 1 other:

NZ_BMMB01000007.1 Lanthipeptides: IEX62_RS15675_lanthipeptide

Lanthipeptides: IEX62_RS15680_lanthipeptide

12

PGGGGVCTLTSEC

24

PG G + TLT +C

3

PGDGWITTLTDDC

15

26.9% NZ_CP050134.2and 3 others:

NZ_EQ973330.1 Lanthipeptides: CORMATOL_RS10565_lanthipeptideNZ_LR134504.1 Lanthipeptides: EL293_RS07240_lanthipeptideNZ_LR134504.1 Lanthipeptides: EL293_RS07240_lanthipeptide

Lanthipeptides: HBA49_RS00770_lanthipeptide

11

LPGGGGVCTLTSECI

25

L G CT+T EC+

5

LGNNGRWCTITKECM

19

26.9% NZ_CP061274.1and 1 other:

NZ_JADKRR010000001.1 Lanthipeptides: ITJ40_RS10085_lanthipeptide

Lanthipeptides: H9X71_RS09850_lanthipeptide

12

PGGGGVCTLTSEC

24

G +CTLT EC

1

ASSGWLCTLTIEC

13

26.9% NZ_LWKZ01000001.1: Lanthipeptides: A6A06_RS41385_lanthipeptide

13

GGGGVCTLTSECIC

26

G CT+T+EC C

2

SSGYFCTITTECFC

15

26.7% NZ_BNCA01000011.1and 1 other:

NZ_BNCA01000011.1 Lanthipeptides: IE314_RS15865_lanthipeptide

Lanthipeptides: IE314_RS15865_lanthipeptide

15

GGVCTLTSEC

24

GG CTLT EC

16

GGWCTLTKEC

25

26.7% NZ_CYXV01000003.1: Lanthipeptides: ARB75_RS04585_lanthipeptide

14

GGGVCTLTSEC

24

GG CTLT EC

8

GGIACTLTGEC

18

26.7% NZ_FNHR01000005.1and 1 other:

NZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05590_lanthipeptide

Lanthipeptides: BLQ37_RS05590_lanthipeptide

8

TFTLP----GGGGVCTLTSECI

25

TF+L G CT++ EC+

5

TFSLSDYMGNNGNWCTISHECM

26

26.7% NZ_RKNR01000012.1and 1 other:

NZ_RKNR01000012.1 Lanthipeptides: EGW35_RS11615_lanthipeptide

Lanthipeptides: EGW35_RS11615_lanthipeptide

11

LPGGGGVCTLTSECI

25

L GG CT T EC+

12

LGNTGGWCTATKECM

26

26.5% NZ_WITJ01000001.1and 1 other:

NZ_WITJ01000001.1 Lanthipeptides: GHI93_RS00065_lanthipeptide

Lanthipeptides: GHI93_RS00065_lanthipeptide

3

MEAACTFTLPGGGGVCTLTSEC

24

+ T L G VCT T EC

8

FSSVVTLALGNNGYVCTWTHEC

29

25.8% NZ_QGGR01000002.1: Lanthipeptides: BC793_RS05490_lanthipeptide

9

FTLPGG---GGVCTLTSEC

24

+T+PG G +CT++ EC

2

YTVPGTSTIGWICTVSWEC

20

25.7% NC_015957.1: Lanthipeptides: STRVI_RS53125_lanthipeptide

15

GGVCTLTSECIC

26

G VCTLT+EC C

24

GWVCTLTTECGC

35

25.0% NC_002570.2and 3 others:

NC_002570.2 Lanthipeptides: AYT26_RS02480_lanthipeptideNZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptideNZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptide

Lanthipeptides: AYT26_RS02480_lanthipeptide

11

LPGGGGVCTLTSECI

25

L G CTLT EC+

14

LGNKGAYCTLTVECM

28

25.0% NC_018499.1and 20 others:

NC_018499.1 Lanthipeptides: BCK_RS27855_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27850_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27860_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27855_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27850_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27215_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27210_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27215_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27210_lanthipeptideNZ_JANIOB010000033.1 Lanthipeptides: NQ113_RS28005_lanthipeptideNZ_JAOPQW010000026.1 Lanthipeptides: OCD10_RS25275_lanthipeptideNZ_JAOPQW010000026.1 Lanthipeptides: OCD10_RS25270_lanthipeptideNZ_JH791925.1 Lanthipeptides: IE3_RS28545_lanthipeptideNZ_MLKL01000042.1 Lanthipeptides: BKK45_RS27570_lanthipeptideNZ_MLKL01000042.1 Lanthipeptides: BKK45_RS27565_lanthipeptideNZ_MLKL01000042.1 Lanthipeptides: BKK45_RS27560_lanthipeptideNZ_NUML01000015.1 Lanthipeptides: COD66_RS20150_lanthipeptideNZ_NUML01000015.1 Lanthipeptides: COD66_RS20145_lanthipeptideNZ_NUVR01000040.1 Lanthipeptides: COI88_RS26655_lanthipeptideNZ_NUVR01000040.1 Lanthipeptides: COI88_RS26650_lanthipeptide

Lanthipeptides: BCK_RS27860_lanthipeptide

15

GGVCTLTSECI

25

GG CTLT EC+

18

GGYCTLTKECM

28

25.0% NZ_CP009288.1and 3 others:

NZ_CP009288.1 Lanthipeptides: PDUR_RS25150_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01580_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01580_lanthipeptide

Lanthipeptides: PDUR_RS25150_lanthipeptide

8

TFTLPGGGGVCTLTSECI

25

+ TL G VCT T EC+

15

SMTLGNNGWVCTATKECM

32

25.0% NZ_JAQDBP010000004.1and 18 others:

NZ_JAQDBP010000004.1 Lanthipeptides: PGY07_RS07085_lanthipeptideNZ_JAQEAL010000002.1 Lanthipeptides: PGU65_RS02165_lanthipeptideNZ_JAQESL010000010.1 Lanthipeptides: PG840_RS09145_lanthipeptideNZ_JAQEUC010000007.1 Lanthipeptides: PG788_RS06860_lanthipeptideNZ_QRHW01000005.1 Lanthipeptides: DW641_RS05035_lanthipeptideNZ_QROS01000011.1 Lanthipeptides: DW021_RS13630_lanthipeptideNZ_QRPQ01000001.1 Lanthipeptides: DWZ74_RS02490_lanthipeptideNZ_QRZZ01000003.1 Lanthipeptides: DWV87_RS03165_lanthipeptideNZ_QRZZ01000003.1 Lanthipeptides: DWV87_RS03165_lanthipeptideNZ_QSJW01000012.1 Lanthipeptides: DW767_RS16350_lanthipeptideNZ_QSJW01000012.1 Lanthipeptides: DW767_RS16350_lanthipeptideNZ_QSKF01000004.1 Lanthipeptides: DW740_RS06305_lanthipeptideNZ_QSKF01000004.1 Lanthipeptides: DW740_RS06305_lanthipeptideNZ_QTZB01000014.1 Lanthipeptides: DXC15_RS13895_lanthipeptideNZ_QUCI01000011.1 Lanthipeptides: DW648_RS10830_lanthipeptideNZ_QUJJ01000004.1 Lanthipeptides: DW748_RS03630_lanthipeptideNZ_QUJJ01000004.1 Lanthipeptides: DW748_RS03630_lanthipeptideNZ_QUKU01000006.1 Lanthipeptides: DXC27_RS05470_lanthipeptide

Lanthipeptides: PGY07_RS07085_lanthipeptide

2

DMEAACTFTLPGGGGVCTLTSEC

24

D+ + +L G VCT++ EC

1

DLTSNKVDSLASSGVVCTISVEC

23

25.0% NZ_KE384107.1: Lanthipeptides: G586_RS23925_lanthipeptide

10

TLPGGGGVCTLTSEC

24

+L G CT+T EC

9

SLGNRGSYCTITKEC

23

24.1% NZ_KV795763.1and 2 others:

NZ_KV804818.1 Lanthipeptides: allorf_114850_115005_lanthipeptideNZ_KV804818.1 Lanthipeptides: allorf_114850_115005_lanthipeptide

Lanthipeptides: allorf_248182_248337_lanthipeptide

15

GGVCTLTSECI

25

G VCT+T EC+

15

GRVCTVTVECM

25

23.8% NZ_BMFU01000012.1and 7 others:

NZ_BMFU01000012.1 Lanthipeptides: IEW26_RS25375_lanthipeptideNZ_JACHKG010000014.1 Lanthipeptides: allorf_027480_027638_lanthipeptideNZ_JACHKG010000014.1 Lanthipeptides: allorf_027480_027638_lanthipeptideNZ_JAHXMW010000012.1 Lanthipeptides: KZX51_RS23855_lanthipeptideNZ_JAHXMW010000012.1 Lanthipeptides: KZX51_RS23855_lanthipeptideNZ_VDYW01000008.1 Lanthipeptides: FS579_RS24445_lanthipeptideNZ_VDYW01000008.1 Lanthipeptides: FS579_RS24445_lanthipeptide

Lanthipeptides: IEW26_RS25375_lanthipeptide

5

AACTFTLPGGGGVCTLTSEC

24

AA ++ + G VCTLT EC

18

AAASYFMGNPGHVCTLTVEC

37

23.7% NZ_LT575476.1and 1 other:

NZ_LT575476.1 Lanthipeptides: BN6628_RS02285_lanthipeptide

Lanthipeptides: BN6628_RS02285_lanthipeptide

8

TFTLPGGGGVCTLTSECI

25

++ L G VCT T ECI

16

SYALGDKGQVCTATVECI

33

23.5% NZ_BQXZ01000001.1and 1 other:

NZ_BQXZ01000001.1 Lanthipeptides: OCU69_RS05000_lanthipeptide

Lanthipeptides: OCU69_RS05000_lanthipeptide

1

GDMEAACTFTLPGGGGVCTLTSEC

24

G + + + G VCT T EC

5

GTISITLSVYMGNKGSVCTWTIEC

28

23.5% NZ_CP040417.1and 9 others:

NZ_CP040417.1 Lanthipeptides: FE328_RS09040_lanthipeptideNZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptideNZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptideNZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptideNZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptideNZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptideNZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptideNZ_KQ040792.1 Lanthipeptides: WH45_RS23330_lanthipeptideNZ_KQ040792.1 Lanthipeptides: WH45_RS23330_lanthipeptide

Lanthipeptides: FE328_RS09040_lanthipeptide

15

GGVCTLTSEC

24

G VCTLT EC

15

GKVCTLTWEC

24

23.3% NZ_KE384533.1and 2 others:

NZ_KE384533.1 Lanthipeptides: K329_RS0118200_lanthipeptideNZ_KE384533.1 Lanthipeptides: K329_RS0118200_lanthipeptide

Lanthipeptides: K329_RS0118200_lanthipeptide

15

GGVCTLTSECI

25

GG CTL+ EC+

16

GGWCTLSQECM

26

23.1% NZ_CP086242.1and 1 other:

NZ_CP086245.1 Lanthipeptides: LL037_RS25615_lanthipeptide

Lanthipeptides: LL038_RS25355_lanthipeptide

12

PGGGGVCTLTSEC

24

G +CT T+EC

1

ASSGAICTATTEC

13

23.1% NZ_MJEH01000022.1: Lanthipeptides: BFG57_RS09480_lanthipeptide

12

PGGGGVCTLTSEC

24

PG G + T+T +C

4

PGDGWISTITDDC

16

22.9% NZ_BIFH01000022.1and 1 other:

NZ_BIFH01000022.1 Lanthipeptides: EMA17_RS23445_lanthipeptide

Lanthipeptides: EMA17_RS23445_lanthipeptide

11

LPGGGGVCTLTSEC

24

L G CTLT EC

17

LGNHGNWCTLTKEC

30

22.2% NC_017299.1and 1 other:

NC_017299.1 Lanthipeptides: H04402_RS03105_lanthipeptide

Lanthipeptides: H04402_RS03105_lanthipeptide

1

GDMEAACTFTLPGGGGVCTLTSEC

24

G + + + G VCT T EC

5

GTISITLSVYMGNDGKVCTWTVEC

28

21.9% NZ_CP101913.1and 1 other:

NZ_CP101913.1 Lanthipeptides: NP440_RS09135_lanthipeptide

Lanthipeptides: NP440_RS09135_lanthipeptide

13

GGGGVCTLTSEC

24

G CTLT EC

11

NDGKYCTLTWEC

22

21.6% NC_015215.1and 5 others:

NC_015215.1 Lanthipeptides: SGGBAA2069_RS00705_lanthipeptideNZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09795_lanthipeptideNZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09795_lanthipeptideNZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05350_lanthipeptideNZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05350_lanthipeptide

Lanthipeptides: SGGBAA2069_RS00705_lanthipeptide

11

LPGGGGVCTLTSEC

24

L G VCT T+EC

19

LGNDGWVCTWTAEC

32

21.6% NZ_BCEY01000006.1and 1 other:

NZ_BCEY01000006.1 Lanthipeptides: GOZ53_RS01290_lanthipeptide

Lanthipeptides: GOZ53_RS01290_lanthipeptide

8

TFTLPGGGGVCTLTSEC

24

+F L G +CT T+EC

16

SFALGNDGWICTWTAEC

32

21.2% NC_018089.1and 13 others:

NC_018089.1 Lanthipeptides: SMUGS5_RS08725_lanthipeptideNZ_CP043405.1 Lanthipeptides: FY406_RS04355_lanthipeptideNZ_CP043405.1 Lanthipeptides: FY406_RS04355_lanthipeptideNZ_CP044493.1 Lanthipeptides: FSA40_RS09065_lanthipeptideNZ_CP044493.1 Lanthipeptides: FSA40_RS09065_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS00325_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS00325_lanthipeptideNZ_JADPAN010000004.1 Lanthipeptides: I4U28_RS03985_lanthipeptideNZ_JADPAN010000004.1 Lanthipeptides: I4U28_RS03985_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS08120_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS08120_lanthipeptideNZ_JAQCYD010000003.1 Lanthipeptides: PGX70_RS05515_lanthipeptideNZ_JAQCYD010000003.1 Lanthipeptides: PGX70_RS05515_lanthipeptide

Lanthipeptides: SMUGS5_RS08725_lanthipeptide

3

MEAACTFTLPGGGGVCTLTSECI

25

+ + + L G +CT+T EC+

6

VNSTFSIVLGNKGYICTVTVECM

28

21.1% NZ_CM000756.1and 7 others:

NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS34475_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptide

Lanthipeptides: BTHUR0011_RS34475_lanthipeptide

10

TLPGGGGVCTLTSECI

25

T G VCT T EC+

18

TFGNKGKVCTYTVECV

33

20.6% NZ_BMVL01000013.1and 1 other:

NZ_BMVL01000013.1 Lanthipeptides: IE257_RS28650_lanthipeptide

Lanthipeptides: IE257_RS28650_lanthipeptide

8

TFTLPGGGGVCTLTSEC

24

++ L G +CT+T EC

12

SWALGNNGHLCTVTVEC

28

20.6% NZ_CP042598.1and 2 others:

NZ_JADPDT010000005.1 Lanthipeptides: I4V19_RS09885_lanthipeptideNZ_JADPDT010000005.1 Lanthipeptides: I4V19_RS09885_lanthipeptide

Lanthipeptides: FUT28_RS13825_lanthipeptide

15

GGVCTLTSECI

25

GG CT T EC+

20

GGWCTATKECM

30

19.4% NZ_CP009280.1and 1 other:

NZ_CP009280.1 Lanthipeptides: P40081_RS01820_lanthipeptide

Lanthipeptides: P40081_RS01820_lanthipeptide

11

LPGGGGVCTLTSECI

25

L G VCT + EC+

18

LGNDGWVCTWSKECM

32

19.4% NZ_JAGKQT010000007.1and 3 others:

NZ_JAGKQT010000007.1 Lanthipeptides: J2M30_RS09860_lanthipeptideNZ_LVYL01000010.1 Lanthipeptides: A3863_RS05855_lanthipeptideNZ_LVYL01000010.1 Lanthipeptides: A3863_RS05855_lanthipeptide

Lanthipeptides: J2M30_RS09860_lanthipeptide

13

GGGGVCTLTSECI

25

G VCT T EC+

20

NDGKVCTYTVECV

32

19.4% NZ_CP034248.1: Lanthipeptides: EIM92_RS14995_lanthipeptide

13

GGGGVCTLTSEC

24

GG +CT++ EC

6

SGGVICTISHEC

17

19.2% NZ_CP039292.1and 1 other:

NZ_CP039292.1 Lanthipeptides: allorf_0090688_0090780_lanthipeptide

Lanthipeptides: allorf_0090688_0090780_lanthipeptide

2

DMEAACTFTLP

12

EAAC+++ P

1

SREAACSWSQP

11

18.9% NZ_CP115450.1and 1 other:

NZ_CP115450.1 Lanthipeptides: O1G21_RS35415_lanthipeptide

Lanthipeptides: O1G21_RS35415_lanthipeptide

6

ACTFTLPGGGGVCTLTSEC

24

A ++ + G +CT+T+EC

13

AASWAMGNNGYLCTVTAEC

31

18.8% NC_006322.1and 7 others:

NC_006322.1 Lanthipeptides: BLI_RS20295_lanthipeptideNZ_CP033218.1 Lanthipeptides: D9Y32_RS07805_lanthipeptideNZ_CP033218.1 Lanthipeptides: D9Y32_RS07805_lanthipeptideNZ_LQYL01000021.1 Lanthipeptides: B4090_RS08835_lanthipeptideNZ_LQYL01000021.1 Lanthipeptides: B4090_RS08835_lanthipeptideNZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11865_lanthipeptideNZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11865_lanthipeptide

Lanthipeptides: BLI_RS20295_lanthipeptide

13

GGGGVCTLTSECI

25

G +CT+T EC+

16

NNGYLCTVTKECM

28

18.4% NZ_BMRY01000003.1and 28 others:

NZ_BMRY01000003.1 Lanthipeptides: IE140_RS12370_lanthipeptideNZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptideNZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptideNZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptideNZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS18205_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptideNZ_CP116355.1 Lanthipeptides: KPP03845_RS17815_lanthipeptideNZ_CP116355.1 Lanthipeptides: KPP03845_RS17815_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptideNZ_WHOM01000078.1 Lanthipeptides: GCN81_RS29300_lanthipeptideNZ_WHOM01000078.1 Lanthipeptides: GCN81_RS29300_lanthipeptide

Lanthipeptides: IE140_RS12370_lanthipeptide

8

TFTLPGGGGVCTLTSEC

24

++ L G CT T+EC

17

SYVLGNNGNFCTATAEC

33

17.9% NZ_LUCO01000016.1: Lanthipeptides: BMBG_RS27155_lanthipeptide

15

GGVCTLTSEC

24

G VCTL++EC

20

GRVCTLSAEC

29

17.6% NZ_LMFO01000023.1: Lanthipeptides: allorf_629531_629758_lanthipeptide

15

GGVCTLTSEC

24

G CT T+EC

18

GNFCTFTTEC

27

16.7% NZ_CP086141.1and 1 other:

NZ_CP086141.1 Lanthipeptides: LL065_RS24800_lanthipeptide

Lanthipeptides: LL065_RS24800_lanthipeptide

8

TFTLPGGGGVCTLTSEC

24

++ L G +CT + EC

16

SYALGNQGKICTWSVEC

32

16.7% NZ_FNVT01000006.1: Lanthipeptides: C4V41_RS24485_lanthipeptide

3

MEAACTFTLPGGGGVC

18

+E+ T T PGG G C

20

VESEITMTGPGGSGRC

35

16.2% NZ_JAQFWW010000005.1: Lanthipeptides: PDT38_RS15180_lanthipeptide

15

GGVCTLTSECI

25

G CTL++EC

21

GKYCTLSAECF

31

12.5% NZ_CP011152.1and 5 others:

NZ_CP011152.1 Lanthipeptides: WR47_RS28815_lanthipeptideNZ_CP011152.1 Lanthipeptides: WR47_RS28820_lanthipeptideNZ_CP011152.1 Lanthipeptides: WR47_RS28815_lanthipeptideNZ_CP011152.1 Lanthipeptides: WR47_RS28810_lanthipeptideNZ_CP011152.1 Lanthipeptides: WR47_RS28810_lanthipeptide

Lanthipeptides: WR47_RS28820_lanthipeptide

10

TLPGGGGVCTLTSEC

24

TL G CT+T EC

45

TLGNKGHACTITKEC

59

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

ctg7_76 - Class II

Cleavage pHMM score: -2.00

RODEO score: 0

Monoisotopic mass: 2399.0 Da

Molecular weight: 2400.8 Da

Number of bridges: 3

Additional modifications: AviCys

Alternative weights: (assuming N unmodified Ser/Thr residues); 2418.8 Da N = 1

gnlProkkaPLCCKAFL_13 - Region 1 - other

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Location: 102,618 - 144,036 nt. (total: 41,419 nt) Show pHMM detection rules used

other: (LmbU or Neocarzinostat or bcpB or frbD or mitE or vlmB or prnB or CaiA or bacilysin or orf2_PTase)

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Gene overview

KnownClusterBlast

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

gnlProkkaPLCCKAFL_16 - Region 1 - NRPS,T3PKS,transAT-PKS

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Location: 1 - 44,033 nt. (total: 44,033 nt) Show pHMM detection rules used

Region on contig edge.

transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
NRPS: cds(Condensation and (AMP-binding or A-OX))
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

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Gene overview

NRPS/PKS domains

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Detailed domain annotation

Selected features only

Show module domains

Similar known gene clusters from MIBiG 3.1

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 44033:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Gly - ccmal - ohmal - mal) + (ccmal - mal - ohmal - mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg16_4

PKS_AT (8..289): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 98.2
inactive: 51.6
Methoxymalonyl-CoA: 36.5
Methylmalonyl-CoA: 23.7
Propionyl-CoA: 20.0
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

ctg16_5

PKS_AT (7..295): mal

ATSignature: (unknown)

No matches above 50%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 35.2
inactive: 24.3
Methoxymalonyl-CoA: 14.4
Benzoyl-CoA: 12.5
Isobutyryl-CoA: 9.4
Methylmalonyl-CoA: 9.2
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

ctg16_6

PKS_AT (4..282): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 66.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 87.4
inactive: 28.2
Methoxymalonyl-CoA: 23.4
Methylmalonyl-CoA: 10.9
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

ctg16_11

Search NORINE for peptide: strict or relaxed

CAL_domain (74..476): pk

minowa: fatty_acid

Prediction, score:

fatty_acid: 26.0
NH2: 9.4
shikimic_acid: 0.0
Acetyl-CoA: 0.0
AHBA: 0.0

AMP-binding (1145..1540): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: DILQLGMIWK
Nearest Stachelhaus code(s):: Gly DILQLGMIWK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

gnlProkkaPLCCKAFL_21 - Region 1 - terpene

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Location: 90,597 - 111,337 nt. (total: 20,741 nt) Show pHMM detection rules used

terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.

gnlProkkaPLCCKAFL_22 - Region 1 - T3PKS

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Location: 105,201 - 142,342 nt. (total: 37,142 nt) Show pHMM detection rules used

Region on contig edge.

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.

gnlProkkaPLCCKAFL_23 - Region 1 - NRPS

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Location: 3,804 - 26,237 nt. (total: 22,434 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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NRPS/PKS domains

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Detailed domain annotation

Selected features only

Show module domains

Similar known gene clusters from MIBiG 3.1

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 3803 - 26237:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Val)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg23_28

Search NORINE for peptide: strict or relaxed

AMP-binding (248..645): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: DAFWLGGTFK
Nearest Stachelhaus code(s):: Val DAFWLGGTFK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

gnlProkkaPLCCKAFL_27 - Region 1 - phosphonate

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Location: 39,329 - 51,470 nt. (total: 12,142 nt) Show pHMM detection rules used

phosphonate: (phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase or phosphonatesMeIsocitrateLyase))

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No matches found.

gnlProkkaPLCCKAFL_28 - Region 1 - NRPS

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Location: 1 - 25,496 nt. (total: 25,496 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 25496:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Leu)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg28_2

Search NORINE for peptide: strict or relaxed

AMP-binding (469..867): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: DAFFLGCVFK
Nearest Stachelhaus code(s):: Leu DAFFLGCVFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

gnlProkkaPLCCKAFL_42 - Region 1 - NRPS,transAT-PKS

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Location: 1 - 33,842 nt. (total: 33,842 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))

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No matches found.

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 33842:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-Asn - Gly) + (ccmal) + (ccmal) + (mal - D-Glu)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg42_1

Search NORINE for peptide: strict or relaxed

AMP-binding (147..541): Asn

nrpys: Asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asn (Asn)

Stachelhaus prediction details:

Stachelhaus sequence:: DLTKIGEVGK
Nearest Stachelhaus code(s):: Asn DLTKIGEVGK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1649..2042): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: DILQMGMIWK
Nearest Stachelhaus code(s):: Gly DILQMGMVWK (85% 8Å match)
Stachelhaus code match:: 90% (moderate)

ctg42_2

PKS_AT (6..293): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 83.3%; inactive: 75.0%; 2-Methylbutyryl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 111.1
inactive: 50.8
Methoxymalonyl-CoA: 39.3
Isobutyryl-CoA: 31.6
Methylmalonyl-CoA: 29.7
Propionyl-CoA: 12.0
CHC-CoA: 10.8
fatty_acid: 10.4
Benzoyl-CoA: 10.0
trans-1,2-CPDA: 0.0
Ethylmalonyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

ctg42_6

Search NORINE for peptide: strict or relaxed

AMP-binding (1197..1598): Glu

nrpys: Glu

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAKDIGVVDK
Nearest Stachelhaus code(s):: Glu DAKDIGVVDK (82% 8Å match)
Stachelhaus code match:: 100% (strong)

gnlProkkaPLCCKAFL_44 - Region 1 - transAT-PKS

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Location: 25,110 - 93,588 nt. (total: 68,479 nt) Show pHMM detection rules used

Region on contig edge.

transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))

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NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 25109 - 93588:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (ohmal - ccmal - ccmal) + (ccmal) + (ccmal - mal) + (ccmal - mal) + (ohmal) + (ohmal - mal)
Non-colinear ordering:: ctg44_51 + ctg44_50 + ctg44_49 + ctg44_48 + ctg44_47 + ctg44_46 + ctg44_45

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg44_52

PKS_AT (4..282): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 92.6
inactive: 32.0
Methoxymalonyl-CoA: 28.0
Methylmalonyl-CoA: 20.8
Propionyl-CoA: 17.4
fatty_acid: 13.9
trans-1,2-CPDA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

gnlProkkaPLCCKAFL_45 - Region 1 - NRPS

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Location: 91,436 - 119,099 nt. (total: 27,664 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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Predicted core structure(s)

For candidate cluster 1, location 91435 - 119099:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Glu - Leu)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg45_104

Search NORINE for peptide: strict or relaxed

AMP-binding (465..867): Glu

nrpys: Glu

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: gln (Gln)

Stachelhaus prediction details:

Stachelhaus sequence:: DAKDLGVVDK
Nearest Stachelhaus code(s):: Glu DAKDLGVVDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1511..1908): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: DAFMMGMVFK
Nearest Stachelhaus code(s):: Leu DAFMMGMVFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

gnlProkkaPLCCKAFL_50 - Region 1 - PKS-like

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Location: 1 - 36,333 nt. (total: 36,333 nt) Show pHMM detection rules used

Region on contig edge.

PKS-like: (t2pks2 or ksIII)

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gnlProkkaPLCCKAFL_53 - Region 1 - NRPS,betalactone,transAT-PKS

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Location: 1,661 - 89,335 nt. (total: 87,675 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
betalactone: (HMGL-like and AMP-binding)

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NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 1660 - 89335:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-Tyr) + (Ile) + (mal - Asn) + (D-Tyr - D-Asn - Pro - Glu) + (D-Ser - Thr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 1660 - 78910:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal - Asn) + (D-Tyr - D-Asn - Pro - Glu) + (D-Ser - Thr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 61812 - 89335:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-Tyr) + (Ile)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg51_23

Search NORINE for peptide: strict or relaxed

AMP-binding (267..674): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHFSLIDK
Nearest Stachelhaus code(s):: Ser DVWHFSLIDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1789..2188): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: DFWNIGMVHK
Nearest Stachelhaus code(s):: Thr DFWNIGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

ctg51_24

Search NORINE for peptide: strict or relaxed

AMP-binding (268..662): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: tyr (Tyr)

Stachelhaus prediction details:

Stachelhaus sequence:: DALSVGEVVK
Nearest Stachelhaus code(s):: Tyr DALSVGEVVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1779..2174): Asn

nrpys: Asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asn (Asn)

Stachelhaus prediction details:

Stachelhaus sequence:: DLTKIGEVGK
Nearest Stachelhaus code(s):: Asn DLTKIGEVGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3286..3683): Pro

nrpys: Pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: pro (Pro)
Single AA prediction:: pro (Pro)

Stachelhaus prediction details:

Stachelhaus sequence:: DVQFIAHVVK
Nearest Stachelhaus code(s):: Pro DVQFIAHVVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (4325..4732): Glu

nrpys: Glu

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: gln (Gln)

Stachelhaus prediction details:

Stachelhaus sequence:: DAKDLGVVDK
Nearest Stachelhaus code(s):: Glu DAKDLGVVDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

ctg51_25

Search NORINE for peptide: strict or relaxed

CAL_domain (36..478): pk

minowa: fatty_acid

Prediction, score:

fatty_acid: 621.2
NH2: 18.0
shikimic_acid: 0.0
Acetyl-CoA: 0.0
AHBA: 0.0

AMP-binding (2956..3351): Asn

nrpys: Asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asn (Asn)

Stachelhaus prediction details:

Stachelhaus sequence:: DLTKIGEVGK
Nearest Stachelhaus code(s):: Asn DLTKIGEVGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

ctg51_26

PKS_AT (6..290): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%; inactive: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 79.7
inactive: 29.9
Methoxymalonyl-CoA: 21.9
Methylmalonyl-CoA: 13.0
Propionyl-CoA: 11.7
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

ctg51_45

AMP-binding (13..445): X

nrpys: Asp, Asn, Glu, Gln, Aad

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: -GLHIAAPVK
Nearest Stachelhaus code(s):: Z-ahmohOrn FGLHIASTCK (56% 8Å match); Ile DGLFIGIPVK (32% 8Å match)
Stachelhaus code match:: 60% (weak)

ctg51_49

Search NORINE for peptide: strict or relaxed

AMP-binding (473..866): Ile

nrpys: Ile

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: ile (Ile)

Stachelhaus prediction details:

Stachelhaus sequence:: DAFFYGITFK
Nearest Stachelhaus code(s):: Ile DAFFYGITFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

ctg51_50

Search NORINE for peptide: strict or relaxed

AMP-binding (173..565): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: tyr (Tyr)

Stachelhaus prediction details:

Stachelhaus sequence:: DGTITAEVAK
Nearest Stachelhaus code(s):: Tyr DGTITAEVAK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

gnlProkkaPLCCKAFL_56 - Region 1 - transAT-PKS-like

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Location: 1 - 22,869 nt. (total: 22,869 nt) Show pHMM detection rules used

Region on contig edge.

transAT-PKS-like: cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS) and not PKS_AT)

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Predicted core structure(s)

For candidate cluster 1, location 0 - 22869:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (ccmal) + (mal) + (ohmal - mal) + (mal)
Non-colinear ordering:: ctg53_1 + ctg53_4 + ctg53_3 + ctg53_2

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

gnlProkkaPLCCKAFL_58 - Region 1 - NRPS

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Location: 1 - 9,286 nt. (total: 9,286 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 9286:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Val - Asp)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg55_2

Search NORINE for peptide: strict or relaxed

AMP-binding (470..864): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: DAFWIGGTFK
Nearest Stachelhaus code(s):: Val DAFWIGGTFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1502..1904): Asp

nrpys: Asp

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asp (Asp)

Stachelhaus prediction details:

Stachelhaus sequence:: DLTKVGHIGK
Nearest Stachelhaus code(s):: Asp DLTKVGHIGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

gnlProkkaPLCCKAFL_60 - Region 1 - NRPS

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Location: 1 - 3,089 nt. (total: 3,089 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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Predicted core structure(s)

For candidate cluster 1, location 0 - 3089:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Cys)

Direct lookup in NORINE database: strict or relaxed

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NRPS/PKS substrate predictions

ctg56_1

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AMP-binding (43..434): Cys

nrpys: Cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Small clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Single AA prediction:: Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:

Stachelhaus sequence:: DLYNLSLIWK
Nearest Stachelhaus code(s):: Cys DLYNLSLIWK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

gnlProkkaPLCCKAFL_64 - Region 1 - transAT-PKS-like

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Location: 1 - 45,659 nt. (total: 45,659 nt) Show pHMM detection rules used

Region on contig edge.

transAT-PKS-like: cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS) and not PKS_AT)

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

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NRPS/PKS products

Predicted core structure(s)

For candidate cluster 1, location 0 - 45659:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (ohmal - ccmal) + (ohmal - mal) + (Me-ccmal) + (mal)
Non-colinear ordering:: ctg59_1 + ctg59_2 + ctg59_3 + ctg59_4

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

gnlProkkaPLCCKAFL_68 - Region 1 - transAT-PKS-like

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Location: 1 - 5,709 nt. (total: 5,709 nt) Show pHMM detection rules used

Region on contig edge.

transAT-PKS-like: cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS) and not PKS_AT)

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No matches found.

gnlProkkaPLCCKAFL_81 - Region 1 - terpene

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Location: 1 - 14,769 nt. (total: 14,769 nt) Show pHMM detection rules used

Region on contig edge.

terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

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No matches found.

gnlProkkaPLCCKAFL_89 - Region 1 - NRPS,transAT-PKS-like

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Location: 24,594 - 75,518 nt. (total: 50,925 nt) Show pHMM detection rules used

Region on contig edge.

transAT-PKS-like: cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS) and not PKS_AT)
NRPS: cds(Condensation and (AMP-binding or A-OX))

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NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 24593 - 75518:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (ohmal) + (Ala - ccmal - ccmal - Me-ccmal) + (mal - mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg76_51

Search NORINE for peptide: strict or relaxed

AMP-binding (492..896): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVSNMAIIYK
Nearest Stachelhaus code(s):: Ala DVSNMAIIYK (88% 8Å match)
Stachelhaus code match:: 100% (strong)

gnlProkkaPLCCKAFL_102 - Region 1 - NRPS

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Location: 1 - 6,646 nt. (total: 6,646 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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Predicted core structure(s)

For candidate cluster 1, location 0 - 6646:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-Phe) + (Asp)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg86_1

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AMP-binding (264..665): Asp

nrpys: Asp

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asp (Asp)

Stachelhaus prediction details:

Stachelhaus sequence:: DLTKIGHIGK
Nearest Stachelhaus code(s):: Asp DLTKIGHIGK (82% 8Å match)
Stachelhaus code match:: 100% (strong)

ctg86_2

Search NORINE for peptide: strict or relaxed

AMP-binding (147..538): Phe

nrpys: Phe

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Unpolar aromatic ring (Phe, Trp)
Single AA prediction:: phe (Phe)

Stachelhaus prediction details:

Stachelhaus sequence:: DAWTIAAICK
Nearest Stachelhaus code(s):: Phe DAWTIAAICK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

gnlProkkaPLCCKAFL_110 - Region 1 - transAT-PKS

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Location: 1 - 10,886 nt. (total: 10,886 nt) Show pHMM detection rules used

Region on contig edge.

transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))

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NRPS/PKS substrates

NRPS/PKS substrate predictions

ctg91_3

AMP-binding (15..363): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: IGNPTGTIFK
Nearest Stachelhaus code(s):: 2,3-dohHda IGNPTGTIMK (74% 8Å match)
Stachelhaus code match:: 90% (moderate)

ctg91_6

PKS_AT (4..281): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 83.3%; inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 87.7
inactive: 30.9
Methoxymalonyl-CoA: 29.3
Methylmalonyl-CoA: 21.7
Propionyl-CoA: 16.5
2-Methylbutyryl-CoA: 15.4
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

gnlProkkaPLCCKAFL_123 - Region 1 - NRPS

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Location: 1 - 13,051 nt. (total: 13,051 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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Predicted core structure(s)

For candidate cluster 1, location 0 - 13051:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-Orn) + (Tyr - D-Thr)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg96_2

Search NORINE for peptide: strict or relaxed

AMP-binding (474..867): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: tyr (Tyr)

Stachelhaus prediction details:

Stachelhaus sequence:: DGTLTAEVAK
Nearest Stachelhaus code(s):: Tyr DGTLTAEVAK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1509..1905): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: DFWNVGMVHK
Nearest Stachelhaus code(s):: Thr DFWNVGMVHK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

ctg96_3

Search NORINE for peptide: strict or relaxed

AMP-binding (174..579): Orn

nrpys: Orn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Long positively charged side chain (Orn, Lys, Arg)
Small clusters prediction:: Orn and hydroxy-Orn specific (Orn, OH-Orn)
Single AA prediction:: orn (Orn)

Stachelhaus prediction details:

Stachelhaus sequence:: DVGEVGSIDK
Nearest Stachelhaus code(s):: Orn DVGEVGSIDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

gnlProkkaPLCCKAFL_128 - Region 1 - NRPS

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Location: 1 - 9,307 nt. (total: 9,307 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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Predicted core structure(s)

For candidate cluster 1, location 0 - 9307:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-X) + (Pro)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg98_1

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AMP-binding (469..866): Pro

nrpys: Pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: pro (Pro)
Single AA prediction:: pro (Pro)

Stachelhaus prediction details:

Stachelhaus sequence:: DVQFIAHVVK
Nearest Stachelhaus code(s):: Pro DVQFIAHVVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1500..1860): Gln

nrpys: Gln

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: glu (Glu)

Stachelhaus prediction details:

Stachelhaus sequence:: DAWHFGSVEK
Nearest Stachelhaus code(s):: Gln DAWHFGSVEK (100% 8Å match); Glu DAWHFGSVEK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

ctg98_2

AMP-binding (188..581): X

nrpys: Ala, Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: DVFWIGGTFK
Nearest Stachelhaus code(s):: Ala or Val DVFWIGGTFK (97% 8Å match); Val DVFWIGGTFK (94% 8Å match)
Stachelhaus code match:: 100% (strong)