LOCUS       gnlProkkaBJAINHAM_74   14948 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|BJAINHAM_74.
ACCESSION   gnlProkkaBJAINHAM_74
VERSION     gnlProkkaBJAINHAM_74
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-30 20:16:17
            Original ID  :: gnl|Prokka|BJAINHAM_74
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 2439
            Orig. end    :: 17387
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14948
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:11512]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11512
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..14948
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14948
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             448..693
                     /locus_tag="ctg74_4"
                     /transl_table=11
                     /translation="MEQIADFIKQLYEYYYLKKNEIKKLQKNISPELLASFGRQLTKTE
                     DTKVELHKAVLNLAKKVMPDKRKTQIYAHFLEKESV"
     CDS             complement(881..1984)
                     /locus_tag="ctg74_5"
                     /transl_table=11
                     /translation="MNTTARIALKLIPNSLQTQPVFLCVDDTMVSKFGTKFENVSKLFD
                     HAAHNGSNYLNGHCFVSVMLCVPVWNHDKVSYLSVPLGYRMWQKKESKLELAASMIRQV
                     MPEFHGKEHVIILCDSWYTKQNLVSVIDEYPNLDLIGNARTDSVMYDLEPARTGHRGRP
                     AKHGKRLSVETDFTFSNEKIGDYYTGVRRVLTRIFGTREVLAYVTAAEKEHGTKRLFFS
                     TVFPEDLQIFCAWQEKAPLNQTGSDRMKYIPLFLYSFRWNIETSYYEQKTFWSFCSYMV
                     RSCKGMEMLVNLINISYCAMKILPYQNEHFSEYRTKSVQEFRFELSQGIRSQIFFATFV
                     KNIETHIKSNAMTRALKQLVCQQVYHL"
     CDS             2393..3058
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 209.9; E-value: 5.8e-64)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg74_6"
                     /transl_table=11
                     /translation="MHNILIVEDDKDIQETLELFLKDNGYMTDKASNGIEAIDKFETNK
                     FDLILLDIMLPKVDGYAVCENIRKKSQIPIIIISALSSEENQIKGLDLQADDYIIKPFS
                     IPILLRKISAIFRRNKYNEEIGVLIYKNVKLDLDSYKAFVSDKEVMLTKREFEILHELI
                     LNQGKILTREILMERVWQYEYIGNARIVDNHIKNIRKKIGDEVIKTIRGVGYKVDKIY"
     CDS             3111..4451
                     /gene_functions="regulatory (smcogs) SMCOG1003:sensor
                     histidine kinase (Score: 132.5; E-value: 4.2e-40)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg74_7"
                     /transl_table=11
                     /translation="MGLITYNFIMIFTPQTYLDKINKNIDSVLNETIGQFSDMTMSQCK
                     VKLLNLTKSYDIMINLTDEKGREIEFGSDMQYTADYQDVRWKIRTNIEKKYTFKPKNES
                     DTYYIYVLSDGERVNLYIDSLKEILPELIILILFISLVLSILYAKHVAVPVIRISELAR
                     KLADLNFVNYVDTGRKDELGRIEESLYELSERLSVALSELENANENLREEIEKERNMEK
                     QQLSFFSSASHELKTPITALKGHLQGMLYDVGEYKEHRKYLKRCLDIIENMQKLETEIM
                     SSAKIRSSGFKMNISKFDLRMLVIEVINEYEDVAMHRGITIQDELGDEVAYIKADYDLL
                     KRAVSNIISNAIRYSPENGNIKITIDDNEKAERLSVINQGSQIPENQIQKMFLPFARLE
                     ESRNKETGGSGVGLYLVKMILDLHKFSYCLRNKEANSIEFEILFFYK"
     CDS             complement(4693..5169)
                     /locus_tag="ctg74_8"
                     /transl_table=11
                     /translation="MIHNKTPEEKYEERQKQSRPVMDALFEWLHTMEDSVDRSSLIGDA
                     ILYTLNQEVYLRRYLEDGHLSIDNNSAERALKNFAVGRRNWLFAKSVRGADASALVYSI
                     TETALLNNLKPYAYLTYILDELRKMGAFPKEEELKKLLPWSEYLPEYCRTKLKK"
     CDS             complement(5180..6340)
                     /locus_tag="ctg74_9"
                     /transl_table=11
                     /translation="MEPIFTDKQLNNMSREDLISLMKIVQEQTKKKDTEIQLLKEKQKE
                     LEFLNAMLSDRLTLAQRKQFGASSEKYAEGYEQMNLFNEAEASADAETEELFEEIRPSS
                     YKRKKRKGKKEEDLSNFETVETRTYKLEGEARYCPECGKKYNVVTKEIVKRLRFVPAKF
                     AVEEEITYVYSCPKCGSMKRPEKEPSLIRGSIATPSLVAGIMNAKYVNGMPLARQEREF
                     ARYDLDLSTKTMANWIINCADRYLKPLYQLMKEELLESRYIHCDESRIQVLGEPDQEGT
                     TQNWMWVYLTDESSGSPQMVLFDYERTRAGYHPVNFLGNRFRGYLTCDGYQAYHSLGEG
                     IIVSGCLTHARRRFDAALTALKKRLHKRTAERDRCISGDVKDRDPL"
     CDS             complement(6839..7180)
                     /locus_tag="ctg74_10"
                     /transl_table=11
                     /translation="MNKEEKAKLWSDRIQQYQTSGQTCKQWCTENGIPLSTMGYWIRRF
                     AKEEPASESEQDMVFVRLPSEQEAARKLLSEESSSVRIFISDSIRIEISDSCRMELMES
                     ILGFLQRHA"
     CDS             7626..8903
                     /gene_functions="other (smcogs) SMCOG1229:transposase
                     (Score: 276.7; E-value: 4.2e-84)"
                     /gene_kind="other"
                     /locus_tag="ctg74_11"
                     /transl_table=11
                     /translation="MPNTVKVLKLTTDEKSSLECLLRCPTTEARKYIRAKILLLKSDSY
                     TNEAIADKLDITVPTVRLCLQKYFAGGIDNALNDCKGKGRKQEISDDDITWVVNKACQK
                     PLDYGFSAEFWYPASFTRFIQSIAVKEEHPRLEHVSEFSLRKILANAKIRPFKVTYYCE
                     RRDPDFDSKMHNVLVIYKQVSLQFDKDGNLLPFEGTPVHTLSYDEKPGIQAIGSTTPDL
                     PPISNTEKGSSYMRDYEYIRYGTISLLAAIDLLTGEAIPLVSDTHKSSDFVEFLTRLDA
                     KYPEVDKIRLILDNHSAHTSQETQRYLNNHLGRFEFVFTPTHGSWLNLVEGFFSKLTKQ
                     MLQGIRVASKEELSERIYKYFDEINQIPIPYHWSYNLDSIDLATEDIDQIVYKVVNAKA
                     ASEELSCKRAPKPIKRSPKKSAKTEN"
     CDS             9365..9565
                     /locus_tag="ctg74_12"
                     /transl_table=11
                     /translation="MEITFLIQQTLIDGIDVGSGTHYARAFCWCNYEYSKKLFAFSNDE
                     VGALHLKARWTIQLRNHDNWK"
     CDS             10001..11512
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Ranthipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Other_Sactipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg74_13"
                     /sec_met_domain="Other_Sactipeptide_rSAM_RRE (E-value:
                     1.5e-13, bitscore: 41.0, seeds: 13, tool:
                     rule-based-clusters)"
                     /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 1.1e-08,
                     bitscore: 25.3, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 7.6e-14, bitscore: 42.5,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 4.9e-10, bitscore: 29.9,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRLYNAIPVKNYKSLGTVFETTSGLYVYDTGTGKVFSCNEVTYN
                     LFKIIFSGGDTNEIYEKYSAQEINKSISEIIEMIQKENILQASYSEFDRETDFELEAIY
                     NYSLQSLILEVTQKCNFRCKYCIYHSFNEYYRNYGLQDMNWETAKKAIDYVSRHSGEKE
                     LSIAFYGGEPLINYDVMKKTIEYSEMVMPKKTLIFAFTTNLSLMTLEKAKFFAKHNCYI
                     MCSLDGPKIIHDAYRVDIKGDGTFNKVIEGLKNLLIAFGDRAKTHIKFNVVICPPYSRK
                     KLDAIKEFFDKLDYLPAGIDIKYSYVESGSLRKEDIDYTYFPEGEDIIGDVPPIDIWLT
                     EELPKQSSDQNVIFTLARDALARVHKRFLLDHPCEKMKRNGCCIPGGRRIYVDIKGNIA
                     LCERVGKSPSLGNINKGIDLEQVKRYYLEEYEKASVEQCKNCWAVNLCNMCYAACYREN
                     GIDIEAKNELCTYQKDQLKGELIMYHQVLETNPELLEHIQDIEII"
     CDS             11561..11767
                     /locus_tag="ctg74_14"
                     /transl_table=11
                     /translation="MKLVNPLGRTVDTLESKADYVSPRSGCVCSGPSGTAASHNKGSGW
                     CVGYCGGETTETRHENMLNAKTA"
     CDS             11845..13635
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 166.9; E-value:
                     1e-50)"
                     /gene_kind="transport"
                     /locus_tag="ctg74_15"
                     /transl_table=11
                     /translation="MRMKNIKEYTAIIVKVIKLSYLSSKKYTIILWGINIMIGIAFPIS
                     TFIWSIFIDKATIGILSNEWKIAALWLGGYSIFWFIQNILNVINEYIENILSAKLNIYT
                     TDKIMKCIADLPMEYFDKSENYDKIQKVNTESNMRSMSIIKTLINLIQGILTMLGTVII
                     LLQVNWIILIILFFLCIPTLVLSLNLSFEKYNIYNARVKDMRFISFLKNMMSEYENIKE
                     LRVNLSSEFFINYIDKKYREFLKVDRKIQSKYSFKMIGMDCIEQIIICSMRIYLLINVV
                     IRNMSIGQLSLHINSIDNFRNSIITILNTMASIYEDGLYVNNLFEFLEIKNNIMRENQK
                     YIQEISKVEFRHVWFKYPNTEKYILEDINFVIEKGKSYSFVGLNGSGKTTIIKLILNLY
                     NPTRGEILVNDINLSNIDMEEYLSKIGVVFQDFMKYPLTISENISIASVRQMNNKNKIE
                     KAAKLSGADQFINKLPKKYDTSLFREWEDGVQLSIGQWQKIAISRAFLEDFPVIILDEP
                     TASLDAYAEFELYKKFKDIVKNKTSILIAHRFSTIKLADLIYVIKNGKIIESGSHNELM
                     KLNGEYAYLYRIQSDAYVSK"
     CDS             13648..14796
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M16"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg74_16"
                     /sec_met_domain="Peptidase_M16 (E-value: 4.1e-08, bitscore:
                     23.4, seeds: 24, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYRWFDFGEKKIPYYKKEIGENSDLLHCALSIKKGSMQDYIAGT
                     AHCLEHMMIENEHVSSINWDLVDRWAHTDFYETTYYFYASVENFEYIYDIIQGILSGDW
                     LKKNVFSNIWPGIIEEYSNEISKVDNAKKKALFSKSIYEEKMPIGVCDSIYKIQYEDIE
                     NYFIENYLKSIPVFIVAGDTIRFEKMYKEKIVSGEYDVMKDRVNCMPLSFDNDLIIKNM
                     EVTHIYINVDIEQRPIFYQYEALYVRAYIAANCMNFILKKELGHNLHFIECRLVRLSKG
                     FCLIDIMFKKTIYDNFKIIGLIKNIKWWGYLDYIYKEIHLFMKQYCKVIGTNLGNTVNK
                     ILNHTIYGANYIEDRSLFQIRAEDIITFLEGLALYHKFRIVV"
ORIGIN
        1 gttttccgag gcttccgatt ataataacag ccgatggatt gtatgtcagc cagaaggtta
       61 tacaaacctg tacggataat ggctgggatt atatcatccg ttataaagaa ggatgtgcac
      121 catccatagc acaggaatat caagaactgc ctgaaaaaga aaagataggt tcagaaatag
      181 aataccagaa tcagattatg tttcagaata cagatgtaaa tctgatatat tatacagaaa
      241 agaaaattca ggcagatggg gaagaaaaaa taacaaaatt tgcatggatt acaaatatca
      301 caattaccaa aagcaatgca aagaaaattg tgaaagccgg aaggaacaga tggaaaatag
      361 aaaacattta accgccagaa gcattggcag ggaaatatag agcatgcatg cagttggaat
      421 gaacaggcac aaaagaacca ttatctgatg gagcagatag cagatttcat aaagcagctt
      481 tatgaatatt attacctgaa gaaaaatgaa ataaaaaaac tgcaaaaaaa tatatctcct
      541 gaattgttag ccagctttgg acgtcaacta acaaaaacag aagatacaaa agtggagttg
      601 cataaagcag ttctaaactt agcaaagaag gtgatgcctg acaagaggaa aacacaaatt
      661 tatgcacatt ttttagagaa ggaatccgta taatcattca atgtgaataa cttttctaaa
      721 tttataagaa aatgtgtaaa tatgtggatt tacaaaattg gcaggctata aaataaattt
      781 acctttcgaa gctggtatcc aagggaaaat cttgacaagc cgtaaaaatg taatataatt
      841 attttataga gattaatagt gaatacacca gtttacaact ttataaatgg tagacttgct
      901 gacaaaccaa ctgttttaaa gcccttgtca tagcatttga ttttatgtgt gtttcgatat
      961 ttttcacgaa agtggcaaaa aatatctgac tgcgaatacc ctgacttaat tcaaaacgaa
     1021 actcctgtac actcttggtg cggtactcag aaaaatgctc gttctgataa ggcagaatct
     1081 tcatagcaca gtaactgatg ttaatcaggt taaccagcat ctccatccct ttgcagcttc
     1141 gcaccatata gctgcaaaaa gaccagaatg ttttctgctc atagtagctc gtttcaatat
     1201 tccagcgaaa cgagtataga aagagtggaa tgtatttcat ccggtcactg cctgtctggt
     1261 tcagtggtgc tttctcctgc catgcacaga aaatctgcag atcttctgga aaaacagtgc
     1321 tgaagaacag ccgttttgtg ccatgctctt tttcagcggc agtgacatac gcaaggactt
     1381 cacgggtacc aaagatcctg gtcagaaccc ggcggacacc ggtataataa tctccaatct
     1441 tttcattgga aaaagtaaaa tctgtctcaa cagaaaggcg tttgccatgt ttagcaggac
     1501 gtcccctgtg tccagtgcgc gcaggctcaa gatcatacat gacagagtca gtccttgcat
     1561 taccaatcag atccaggttt ggatattcat caatgacaga taccaggttc tgttttgtat
     1621 accagctgtc gcaaagaata atgacatgtt ctttgccgtg aaattctggc ataacctgcc
     1681 ggatcatgga tgcggccaat tccagttttg attctttttt ctgccacata cgataaccga
     1741 gaggaacaga aaggtacgat accttatcgt gattccagac gggcacgcag agcatgacgc
     1801 tcacaaagca atgtccattc aaatagttgg aaccattgtg tgcagcatgg tcaaacagtt
     1861 ttgaaacgtt ttcaaacttt gtgccaaatt tagataccat tgtatcatca acacacagaa
     1921 ataccggctg cgtctgtaat gaattcggta tcagcttcaa agcaatccgg gcagtggtat
     1981 tcataaatct ggaataatca acttttgcat aggaacatgc ataataaaat acattcagtg
     2041 atttttctgt taccccggat aaaaaatgct gataaagaaa acggatggaa tgcgcggatt
     2101 ccaaagccag tatggataat atcaacagaa acagggtatc tgctgttgga acagaaaaag
     2161 tttcaaaata aatcaaaaaa tattgatgaa gtctaccaat cagtgttttt tcgttgtata
     2221 atgtttttgt cgtacagggt cactttcctt tgtaatgttt tttgccaaat tcattataca
     2281 tcagaaagtc ctgtacgata tttttttatg aaaaagttgt aaagtggtgt agtgaatagt
     2341 cattttatta tttgttacta atgtttctat gaattagaaa gaggaataac ttatgcataa
     2401 tattttaatt gttgaagatg ataaagatat acaagaaaca ttagagcttt ttttgaaaga
     2461 taatggatat atgacagaca aagcaagtaa tggaattgaa gcaatagata aatttgagac
     2521 gaataaattt gatcttatat tattagatat aatgctgcct aaagttgatg gttatgctgt
     2581 ctgtgagaat attagaaaaa aatctcagat tcccataatt attataagtg cactttcaag
     2641 tgaagaaaac caaataaaag gattagattt acaagcggat gattatatta ttaagccttt
     2701 ttcaataccg attttgctac gtaaaataag tgcaattttc agaagaaata aatataatga
     2761 ggaaataggt gttttgattt ataaaaatgt caagttggat ttggatagct ataaggcatt
     2821 tgttagtgat aaagaagtta tgttgacgaa aagagaattt gaaattttac atgaacttat
     2881 tttgaatcaa gggaaaatat taactagaga aatattaatg gaacgcgtat ggcagtatga
     2941 atatataggt aatgcaagga ttgtagataa tcatataaaa aatattagga aaaaaatagg
     3001 tgatgaagta attaagacta ttagaggagt agggtataag gttgataaga tatattaaat
     3061 ctcatttaag cgtacaggtc ttttttctta cactaattat gcaaattagt atggggctga
     3121 ttacctataa ttttattatg atttttacac ctcagacata cttagataaa ataaataaaa
     3181 atatagattc tgttttaaat gagacgatcg gtcagttttc tgatatgaca atgagtcagt
     3241 gtaaggttaa attgttaaat ttgacaaaaa gttatgatat tatgataaat ttaacagatg
     3301 agaaagggag agaaattgaa tttggaagtg atatgcagta tacagcagat tatcaagacg
     3361 ttagatggaa aataagaaca aatatagaga aaaaatatac gtttaaacct aaaaatgaaa
     3421 gtgacacata ttatatatat gtactttcgg atggtgaaag agtaaatctc tatatagact
     3481 cattaaaaga aatattgcca gagcttatca ttttaatact atttatttct ttggtgttgt
     3541 caatattata cgcgaaacat gtagcggttc cggtgataag aatttcagag ctggctagaa
     3601 aactagcaga tcttaacttt gttaattatg ttgatacggg tcggaaagac gaattgggaa
     3661 gaatagaaga aagtttgtat gagctatcag aacgtttaag cgttgcgctt agtgaattag
     3721 aaaatgcaaa cgaaaatttg cgagaagaaa ttgaaaaaga gaggaatatg gaaaaacagc
     3781 aactttcgtt tttttcatca gcctcacatg agttaaaaac accgattact gcattaaaag
     3841 gacatttaca aggaatgtta tatgatgtgg gagaatataa ggaacatcgt aagtatttaa
     3901 aacgatgtct ggatattatt gaaaatatgc aaaagttaga aacagaaata atgtcgtcag
     3961 caaaaatcag atcttctgga ttcaagatga atatttcaaa atttgaccta aggatgttgg
     4021 taatagaagt tattaatgaa tatgaagatg ttgctatgca tagggggata actatccaag
     4081 atgaattggg agatgaagtt gcatatatta aagcagatta tgatttgttg aaaagagccg
     4141 ttagtaatat tattagtaat gcaatacgct attctcctga aaatggaaat atcaaaataa
     4201 cgatagacga caatgaaaaa gcagagcgtt taagtgttat taatcaggga agtcaaatac
     4261 cagaaaatca aatacagaaa atgtttttac catttgctag actggaagaa tcgcgaaata
     4321 aagagactgg tggtagtggg gtgggattat atttagtaaa gatgattctt gatttacata
     4381 agttctctta ttgcttgcgt aataaagaag caaatagcat agaatttgaa atattatttt
     4441 tttataaata ggaatttatt gttattttct ataatatatt gcagtgcaca gtaatgattt
     4501 agtaaagttt agtaagtagg taatcatccg tatattgaca ttttataaaa gccatctgat
     4561 attgttcctg gctgtctgcc agattctata tcagatgtaa gtaggtaatc attcgtatat
     4621 tgacatctta taaaagccat ctgatactgt tcctggctgg atttgccagt tcctatatca
     4681 gatggcttag tattattttt ttagtttagt ccggcagtat tccggaagat actctgacca
     4741 tggaagcagt ttctttaatt cttcctcttt aggaaaagct cccatttttc tgagttcatc
     4801 caatatatag gtcagatatg cgtatggttt cagattgttc agaagtgccg tttctgtaat
     4861 gctgtaaaca agggcgctgg catcagctcc ccgtacactt ttggcaaaca gccagttgcg
     4921 gcgtcccact gcaaagttct tcaatgcgcg ttctgcactg ttgttatcta tgctgagatg
     4981 accatcttcc agataacgcc tcagatatac ttcctgatta agcgtataca aaatggcatc
     5041 accaataagg gaagacctgt ctacagaatc ttccatcgta tgcagccatt caaacagggc
     5101 atccataacc ggacgggact gtttctggcg ctcctcatat ttttcttccg gtgttttatt
     5161 gtggatcatc tcctcgatct tatagaggat cccgatcctt gacatcgcct gatatgcaac
     5221 ggtctctttc agctgttctt ttgtgaagtc ttttttttaa tgctgtgagg gctgcatcaa
     5281 aacgtcgtct tgcatgggta aggcacccgc ttactatgat accttctcct aaactgtgat
     5341 aagcctgata tccatcacag gtcagatacc cacgaaacct gttccctaaa aagtttacag
     5401 gatgatatcc cgcacgggtc ctttcataat cgaagagtac catctgcggg gaaccactgg
     5461 attcatccgt gagatatacc cacatccagt tctgggtcgt cccttcctga tccggttctc
     5521 cgagtacctg gatacggctt tcgtcacaat ggatatatct gctttccaga agttcttctt
     5581 tcatcagctg atacagcggt ttcaggtatc tgtctgcaca gtttatgatc cagttcgcca
     5641 tagtctttgt ggagagatcg agatcatatc tggcaaactc tctttcctga cgtgccagag
     5701 gcattccatt tacatattta gcattcatga taccggcgac aagggaaggc gtagcgatac
     5761 ttccacggat cagggaaggt tctttttccg gacgtttcat ggacccgcat ttcgggcagc
     5821 tgtatacata agtgatctct tcttcaaccg caaactttgc aggtacaaag cgcaggcgtt
     5881 ttacgatctc ctttgttact acattgtatt tttttccgca ttccggacag taacgggctt
     5941 ccccttccag tttataggtc ctggtctcaa cggtctcaaa attggaaagg tcttcttcct
     6001 tctttccttt tcttttttta cgtttataag aggatggccg gatctcttca aaaagttctt
     6061 ctgtttctgc atccgcactg gcttctgcct cattgaacag gttcatctgt tcatagcctt
     6121 cggcatattt ttcactggat gcaccaaact gtttcctctg tgcaagggta aggcggtcag
     6181 agagcatggc atttaagaat tcaagttctt tctgcttttc tttcagcagc tggatctcgg
     6241 tatctttttt ctttgtctgc tcctgcacga tcttcatcaa tgagatcaga tcttcccggc
     6301 tcatgttatt cagttgttta tctgtaaaga tcggttccat atcctgttct ccctgcttta
     6361 gcgttattaa aagtatatca tggttccagc tgttttccta taaaaaactg cgcttacgga
     6421 tataggaaat acgctgggaa atgccatgtt tttcatgatt tttacgggat tgacagctcc
     6481 gctgtcttat gcttacagga tgatctttgg atggtgttcc tcaaatgcat ccctgggatt
     6541 taaggagagc ccgtcacaca gccagtggat ctctttcaga gtcacctgac ggagttcgtc
     6601 cggagtatcc ggccagtgga aggcattacg gtcgagccgt ttcatcagga tccagaatcc
     6661 ggatccgtcc cattgaagga tttttataga agtacgccga cggttgcaga acgcaaacat
     6721 gcagcgtgag tatgggtcga ggtgaaattt taatttgatg atagccgcca gaccattgta
     6781 actttttctt agatcagtga caccacagga gagatatacc gttgtccctc ctgccaggtc
     6841 aagcatggcg ctgcaggaat cccagtatag attccatcag ttccattctg caggaatcag
     6901 atatttcaat acggatactg tctgaaataa aaatacgcac cgatgaagat tcctcagaga
     6961 gcagctttct ggcagcttcc tgttcagatg gaagtctgac aaagaccata tcctgttcag
     7021 actcggatgc cggctcttct tttgcaaatc tgcggatcca gtatcccatc gtagataaag
     7081 ggataccgtt ttctgtacac cattgtttac atgtttgtcc actggtctgg tattgttgga
     7141 tacggtcaga ccagagtttt gctttttctt ctttattcat agtgatatag aatacctcct
     7201 gagtttcaag gagattgtag cagaataaaa aacgaaaaaa cagatacgga tgattaccta
     7261 cttacttttg ttatgagcac agttccttct gttttagaac tttttatatt cctacaatcg
     7321 ttattctgaa aatcccattt ttgcatagtt ttaaaagacg atattttgaa actgccagta
     7381 aactcagaat ggttgctttc tccagaaaga tatgacagta aaactttcag tttgaatggt
     7441 ctgttgtaat gttttttaga gtgaacaggc atcagtgcag tatcctcacc cgctttgtaa
     7501 cttgtaattc atttgcgaat actggtagtg attacactat attctagtcc tagtataatc
     7561 cattttaatt gtctttatgt ttgaagtatg gtatactatt cccataatga aaggggaatg
     7621 atacgatgcc aaatacagta aaagtgctga agcttacaac ggatgaaaaa agctctttag
     7681 agtgtcttct tcgatgtcca acaacggaag ccagaaaata tatccgggca aagattttgt
     7741 tattaaaaag tgattcttat accaatgaag ccattgccga caagcttgat ataaccgtgc
     7801 ctaccgtccg cttatgtctc cagaaatatt ttgctggcgg tattgataat gctttaaacg
     7861 attgcaaagg aaaaggtcgc aagcaggaaa tatccgatga tgacatcaca tgggtggtca
     7921 ataaagcctg ccagaagccg ctggattacg gtttttctgc tgaattttgg tatcccgcca
     7981 gctttactcg ttttatacag tctattgctg tgaaggaaga gcatccaagg ttagaacatg
     8041 tttcagaatt ttctctcagg aaaattcttg ccaatgccaa aatccgtcct tttaaagtca
     8101 catattactg cgaaagaagg gatcctgatt tcgattcaaa gatgcacaat gtccttgtaa
     8161 tttataagca ggtttcactg cagtttgata aagacgggaa tctgctacct tttgagggaa
     8221 cccctgtcca tacgttatcc tatgacgaga aaccgggaat acaagcaatc ggctccacaa
     8281 ctccagatct gccgccgatt agtaatacag agaaaggcag cagctatatg cgggattatg
     8341 agtatatccg ctatggtact atatcgttac tggcggcgat agatcttctt acaggagagg
     8401 caatcccact ggtgagtgat acccacaaaa gttcagattt tgtggagttc ctgacacggt
     8461 tggatgcaaa atatcctgaa gttgataaaa tacgtctcat ccttgacaac cattcggcac
     8521 atacatcgca ggaaacacag cgatatttaa ataaccattt aggaaggttt gagtttgtat
     8581 tcacaccaac tcatggttcc tggcttaact tggtagaagg ttttttcagc aaactcacaa
     8641 agcaaatgct tcaaggtata cgtgttgcca gcaaggaaga actgtcggag cggatttata
     8701 aatactttga tgagattaat cagattccta ttccatacca ttggtcttat aatctcgata
     8761 gtatcgacct ggctacagag gatattgacc agattgtgta taaagttgtc aatgccaagg
     8821 cggcatcgga agaactgagt tgtaaacgtg cacctaagcc tataaaacga agtcctaaaa
     8881 agtctgccaa aacagaaaac taattaaaac ggattatact agttctcgta gagttgtttc
     8941 cttctccaga taatcataaa cggcttggta tttttcaacg aaagataagg atgatggtaa
     9001 tggacgtttt tgaaatgcag tacctttttt caataggata ttggaagaac tagctttaaa
     9061 aaatgaataa acgaaaagag ctggatagtt attctttagg cattgtagtg aacacagtca
     9121 gttttttttg attaaattag tgtataaatg tatcaagaaa taaaaagcga aatttgtctg
     9181 ctataataat accaagaaag gagcttcttg tataattcaa atataaggaa ttccgagaaa
     9241 gaaggttgaa aaaaactcag agtaaaataa gattactgac tttgagcggt tagtaaaaat
     9301 cttattaaac agtgaggtac ttgaaatgaa ttataacaca tagaacgtaa aaattgtata
     9361 tattgtggaa attacttttt taattcagca aactttaatt gatgggattg atgtgggaag
     9421 tggaactcat tatgcaaggg ctttttgttg gtgtaattat gagtactcaa agaagctgtt
     9481 tgcattcagc aacgatgaag ttggagcgct tcatttaaag gctagatgga cgatacagct
     9541 gagaaatcat gataactgga agtaacaagc aaatatattg taacagaaaa atgctcacca
     9601 gaaagtactg ttacaggaaa gaggtcagta atacaataaa aaagaatgag ccgatagttg
     9661 gcaggaatat tttccatggg caaagaccct gtaaagaagc tgagctgaca ccctggttat
     9721 ggaaaagagg aaggagagaa gataggattc agcaatagtc tgataatgct agtagacatg
     9781 ggagtttgtt gccgtagatg gatggggata cactaagtta tgtagaacga aaaaagaaga
     9841 cattttactt cgcccccaat tcactacttt cgtaccagat acagagaaat gtccattcct
     9901 atggttcctt tttctgagat attgattgat gaaacattaa aaatccttga ttttaaagaa
     9961 aaaaagactt gactatatag ggagaaaaaa gatgggtgat atgaagagac tatataatgc
    10021 aattccagtg aaaaactata aaagcttagg gacagtcttc gaaacgacta gtggattata
    10081 tgtatatgat actgggacag gaaaagtttt tagttgcaat gaagttactt acaatttgtt
    10141 taaaataatt ttttctggag gcgatacaaa cgaaatatat gaaaagtatt cagctcagga
    10201 aatcaacaaa tcaatatctg aaataattga aatgatacaa aaggaaaata tactacaagc
    10261 atcgtactca gaatttgatc gagaaacaga ttttgaactg gaagcaatct ataattactc
    10321 attacaaagt cttatccttg aagttacaca aaagtgtaat tttagatgta agtactgtat
    10381 atatcatagt tttaatgagt attatagaaa ttatggctta caggatatga actgggaaac
    10441 agcaaaaaaa gcaatagatt atgtaagtag acattcgggt gaaaaagaat tatcaatcgc
    10501 tttttacgga ggagagccgt taataaatta tgatgtgatg aaaaaaacta ttgaatatag
    10561 tgagatggtt atgccgaaaa aaactttgat ctttgcattt acaacaaatt tatcattaat
    10621 gaccttagaa aaagcaaaat tctttgctaa acataattgc tatataatgt gtagtttaga
    10681 tggtcctaaa attatacatg atgcttatag ggtggatata aaaggtgatg gaacattcaa
    10741 taaagtgatt gaggggttaa aaaatcttct tattgcattc ggagatcgtg ctaaaaccca
    10801 tataaaattt aatgttgtca tatgcccacc ctattcgaga aaaaaattgg atgcaataaa
    10861 agagtttttt gataagttag actacttgcc tgcaggaatt gacataaaat attcgtatgt
    10921 tgagagtgga agtttacgta aagaagatat tgattataca tatttccctg aaggggaaga
    10981 tattataggg gatgtaccac ctatagatat atggcttacg gaagaacttc caaaacaatc
    11041 atcagatcaa aatgttattt ttacacttgc acgagatgca ttggcacgtg tacataaaag
    11101 atttctgttg gatcatcctt gtgagaaaat gaaaagaaat ggttgttgca tacctggtgg
    11161 ccgtcgtatt tatgttgata taaaaggaaa tattgcgtta tgcgagcggg ttggtaaatc
    11221 tccttcttta ggaaatatta ataaaggaat agatttggaa caagtaaaaa gatactattt
    11281 ggaagaatat gaaaaagctt ctgtagaaca atgtaaaaat tgttgggcag tcaatctatg
    11341 taatatgtgc tatgcagcct gttataggga aaatggtata gatatagaag caaagaatga
    11401 attatgtaca tatcaaaaag atcagttaaa aggtgaactt ataatgtatc atcaagtact
    11461 ggaaacaaac cctgaattgc ttgaacatat tcaggatata gaaattatat aggttattat
    11521 tattaataat ataacaataa atttttaagg aggtaagaac atgaaattag tgaacccttt
    11581 aggaagaacg gtcgatactt tggaaagcaa agcggactat gttagtccta gatcaggctg
    11641 tgtatgctct ggtccttctg gaacagcagc aagtcacaat aaaggttcag gttggtgcgt
    11701 aggatattgc ggaggagaaa ctacagaaac acgccatgag aacatgctga acgctaaaac
    11761 agcataaaag ttgctggact agaggaagag atattattga ggtacccaat agtatctctt
    11821 ccttatttag attggggtta gaaaatgaga atgaaaaata ttaaagaata cactgctata
    11881 atagtaaaag taattaaact atcttatttg agttcaaaaa agtataccat tattttatgg
    11941 ggaataaata ttatgatagg tatagcgttt cctattagta cgttcatttg gagtatattt
    12001 atagataaag ctactatagg cattttgagt aatgaatgga aaatagctgc attatggcta
    12061 ggggggtatt ctattttttg gtttattcag aatatactta atgttatcaa tgaatacata
    12121 gagaatattt tgtctgcaaa acttaatatt tatactacag ataagattat gaagtgtata
    12181 gctgatttac cgatggaata ttttgataag tcggaaaatt atgataaaat acaaaaggtt
    12241 aacacagaat ctaatatgag atctatgagt ataattaaga ctttaattaa tcttattcaa
    12301 ggtattctta ctatgctggg aaccgtaatt attctacttc aagttaattg gattatattg
    12361 ataatattgt tttttttatg tattcctaca ttagtactaa gtttgaattt atcgtttgaa
    12421 aagtataata tttataatgc tagagttaag gatatgagat ttatttcatt cttaaaaaat
    12481 atgatgtcgg agtatgaaaa tataaaagaa ctacgcgtga atttgtcatc tgagtttttt
    12541 attaattata tagataaaaa atatagagag ttcttaaaag ttgatagaaa gattcaaagt
    12601 aaatattctt ttaaaatgat tggaatggat tgtattgaac aaataataat atgtagtatg
    12661 cggatttacc tattaataaa tgttgttatt agaaatatga gcattggaca attatcattg
    12721 catattaatt ctatagataa ttttagaaat tcgataatta ctatattaaa tacaatggcg
    12781 tctatttatg aagatggatt atatgtgaat aatttatttg agtttttgga aataaagaat
    12841 aatattatga gagaaaatca aaaatatatt caggaaatca gcaaagtaga atttcggcat
    12901 gtatggttta aatatcctaa tacggaaaag tatattttag aagatattaa ttttgtaatt
    12961 gagaaaggaa aaagttattc ttttgttggg ctaaatggtt caggtaaaac cacaataata
    13021 aaattgattt taaatttata taatcctaca cgtggggaga ttcttgtaaa tgatattaat
    13081 ctgagtaata ttgatatgga ggaatattta tccaaaatcg gtgtagtatt tcaagacttt
    13141 atgaaatatc cgttaaccat aagcgaaaat atatcaattg cttcagtcag acaaatgaat
    13201 aataaaaata aaattgagaa agcagcaaag ttatctggag cagatcaatt tattaacaag
    13261 cttccaaaga aatatgatac ttcattattt agagaatggg aagacggagt acaactttca
    13321 ataggacagt ggcaaaaaat cgctataagt agagcgtttt tagaagactt ccctgtaatt
    13381 atattggatg aaccaactgc atctttagac gcatatgcag agtttgagct atataaaaaa
    13441 tttaaagata ttgtaaaaaa taaaacaagt atattaatag ctcaccgctt ttctacgata
    13501 aagttagctg atttgattta tgttataaaa aatggaaaaa tcatagaatc aggtagtcac
    13561 aatgagttga tgaaactgaa cggagaatat gcatatctat atagaattca atcagatgcg
    13621 tatgttagta agtaaaggaa ggggattatg aaatataggt ggtttgattt tggtgagaaa
    13681 aaaataccat attataaaaa agaaattggt gagaattcgg acttgttaca ttgtgcttta
    13741 tctataaaaa aagggtcaat gcaggattat attgctggaa cagcacattg tcttgaacac
    13801 atgatgattg aaaacgaaca tgtttcttct attaactggg atcttgtgga tagatgggca
    13861 catacagatt tttatgagac aacctattat ttttatgcaa gtgttgaaaa ttttgagtat
    13921 atctacgata ttatacaagg tattctctca ggagattggc taaagaaaaa cgttttcagt
    13981 aatatatggc caggtatcat tgaagaatat tcaaatgaaa ttagtaaagt agataatgca
    14041 aaaaagaaag cactgtttag taaatcaatt tatgaagaaa aaatgcctat aggggtgtgt
    14101 gattccatat ataaaattca gtatgaagat attgagaact actttataga aaactatttg
    14161 aaatctatac cagtatttat agtagcagga gatacaataa ggtttgaaaa aatgtataaa
    14221 gaaaaaatag tatctggtga atatgacgtt atgaaagaca gggtaaattg tatgccatta
    14281 tcatttgata atgatttgat aataaaaaat atggaggtaa cacacatcta tataaatgta
    14341 gatattgagc aaagacctat tttttatcag tatgaagctt tatatgtaag agcatatatt
    14401 gctgcaaatt gtatgaattt tattctgaaa aaagaattag gacataactt acattttatt
    14461 gaatgcagat tagttagatt atctaaggga ttttgcttaa ttgatataat gtttaagaaa
    14521 acaatatatg acaattttaa aatcataggg ttaattaaga atataaaatg gtgggggtat
    14581 ttagactata tttataaaga aatacatttg tttatgaaac aatactgtaa agttataggt
    14641 acaaacctag ggaacactgt aaataaaatt ttaaatcata ctatttatgg tgcaaactat
    14701 atagaggata gaagtttatt ccagattagg gctgaagata taattacatt tttagaagga
    14761 ttggcactgt accataaatt cagaatagta gtataagtat atgcgagata tgattctata
    14821 ggaatatttt ttgttataag aagaatccgc tacgctagag cgtgtttgaa aattaaaaat
    14881 tgtacaaaac atttgttcct aagccctttt tatagtataa taaagaaaaa ggggtgttca
    14941 ttatgttg
//
