LOCUS       c00032_gnlPro..        16714 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|IKGLIOCC_32.
ACCESSION   c00032_gnlPro..
VERSION     c00032_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-03 18:15:16
            Original ID  :: gnl|Prokka|IKGLIOCC_32
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16714
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16714
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1741:6714]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1742..6714
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..16714
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16714
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             103..441
                     /locus_tag="ctg32_1"
                     /transl_table=11
                     /translation="MQTDIMLSKNNNILIIDAKYYSHMTQQQYGIHTLHSNNLYQIFTY
                     VKNKEFELRNYEHTVSGMLLYAQTDEDIIPNNTYHMSGNQISVLALDLNQDFSKISRTL
                     DDIAKNFL"
     CDS             complement(490..633)
                     /locus_tag="ctg32_2"
                     /transl_table=11
                     /translation="MNNAVSYAMDSQVIFQMFFSIVCIAAAIGVSILVLRFMRKFIDFL
                     LQ"
     CDS             1092..1481
                     /locus_tag="ctg32_3"
                     /transl_table=11
                     /translation="MKKLFYPAVFHIAEEGGYWVTFPDFPECLTQGENMQEAYDMAIDA
                     LGLILTDDINDHKELPEPSNITHVDDGVVVIIPYDYLEYNRKYHNKSIKKTLTIPEWLN
                     NEALRLNLNFSQILQDALLNKIQSR"
     CDS             complement(1742..3154)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: PYC_OADA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: HMGL-like"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg32_4"
                     /sec_met_domain="HMGL-like (E-value: 1.9e-43, bitscore:
                     139.9, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="PYC_OADA (E-value: 9.6e-59, bitscore:
                     189.5, seeds: 434, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEIKKKPVKIVETVLRDAHQSLIATRMTTEEMLPIVDKMDQVGY
                     HAVECWGGATFDACLRFLKEDPWERLRKLRDGFKNTKLQMLFRGQNILGYKPYPDDVVE
                     YFVQKSIANGIDVIRIFDCLNDLRNLQTAVDATKKEGGHAQIALSYTIGDAYTLDYWKK
                     TAKNIEEMGADSICIKDMAGLLVPNEATRLVTALKQATDIPIELHTHYTSGVGGMTYLK
                     AVEAGVDIIDTAISPFAMGTSQPATEVMAETFRGTEFDTGFDQKLLGEIADYFRPIREK
                     YIANGLMSPKVLGVNIKTLMYQVPGGMLSNLVSQLEQQGASDKFYEVLEEVPKVRKDFG
                     EPPLVTPSSQIVGTQAVLNVLTGERYKMITNESKALLRGEYGQTVKPMNKEVQKKAIGD
                     EKPITCRPADLLEPELSKIEAEMSQWKEQDEDVLTYALFPQVATEFFKYRAAQENKIDP
                     AKADVKNGAYPV"
     CDS             complement(3312..4436)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg32_5"
                     /sec_met_domain="OAD_beta (E-value: 2.8e-157, bitscore:
                     514.1, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYVVETMTNLAAQTGFAFLKPGNFIMILVALVFLYLAIAKGYEP
                     LLLVPISFGMLLVNLYPSIMEEGGLLHYFYLLDEWSILPSLIFLGVGALTDFGPLIANP
                     ASFLLGAAAQFGIYSAYFLAMLMGFNGKAAAAISIIGGADGPTSIFLAGKLGQTDLMGP
                     IAVAAYSYMSLVPIIQPPIMKLLTTEKERQIKMEQLRTVTKTEKIMFPIVVTVVVCLIL
                     PTTAPLVGMLMLGNLFRESGVVKQLSETASNALMYIVVIILGTSVGATTSAEAFLNVST
                     IKIVVLGLVAFAVGTAAGVLFGKLMCKVTGGKVNPLIGSAGVSAVPMAARVSQKVGAEA
                     DPSNFLLMHAMGPNVAGVIGTAVAAGTFMAIFGV"
     CDS             complement(4470..4838)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 66.6; E-value:
                     4.3e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg32_6"
                     /sec_met_domain="Biotin_lipoyl (E-value: 2.1e-21, bitscore:
                     66.6, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNYRITVNGVAYDVAVEELGAGEASAAPVSTPAAVPAPAKKAAP
                     KTSGSAGAVKITAPMPGKIVAVKAQAGASVKKGDAVLVLEAMKMENEICAAQDGVIASV
                     EVAVGDMVEGGDVLATMN"
     CDS             complement(4933..5277)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg32_7"
                     /sec_met_domain="OAD_gamma (E-value: 1.4e-27, bitscore:
                     87.2, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNVFEQALLNTLMGMGTVFAVLIFISLLISLFVYIPSIERALKNR
                     SSKKEKKAAQEERPAPKRPILEEVVEEEELVDDGELVAVITAAIMAANGGAAVSADKLV
                     VRSIKRVKRR"
     CDS             complement(5290..6714)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Vparvula"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg32_8"
                     /sec_met_domain="CT_Vparvula (E-value: 2.3e-137, bitscore:
                     449.5, seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGNSKMNARERIDYLFDDHSFVEVGGYVSARNTDYNLGAKKVEGD
                     GVITGYGVINDRMVYVYSQDASALGGSVGEMHAKKIASLYDLAMKTGAPVIGMLDCAGL
                     RLQEATDALHAFGTIFNKQAQASGMIPQISAVFGMCGGGSAVMSAMSDFTLMEKENGSL
                     FINSPNALAGNEESRQNTAGAQFQSEQAGNVDFVCETEEGLLDQLRILVDVLPSDYEAE
                     DVYFDNDDDLNRVIPELNDAAYDAAYILKSISDNNMYIETKAAYAKEMVTAFIRLNGET
                     VGAVANQPVDGESVLTRNGLEKAERFIKFCDAFSIPLLTVTNVTGLRANAHEERKQALA
                     LAKFTTTLAQVSVPRINLIAGEAYGTAAEVMNSKAIGADFVLAWPQASVGMMDAEQAVR
                     IMYAEEINTDKNKTALIAEKTAEYAEGQSSALAAAKRGYIDDIIEPDATRKRLIAAYEM
                     LYGKKVTPVTKKHTAV"
     CDS             7437..8078
                     /locus_tag="ctg32_9"
                     /transl_table=11
                     /translation="MENRKIQFRSKACNLHLSAYPGHFATKHSHVNYFLDMTTLKVRQS
                     NAEEAARALVPLYKHNTVVDTIVCLDGTEVIGAFLAEKLTESGFFSYNQHKSIYIVTPE
                     IDSDGQMFFRKNIQPMIKDRNIIILMASVTTGITINRSWECIEYYGGKLQGISAIFSTL
                     SEYGNLPVNALFTPNDIPTYHTYDKHDCPYCKSGQKIDALVNGHGYSELL"
     CDS             complement(8212..9225)
                     /locus_tag="ctg32_10"
                     /transl_table=11
                     /translation="MQKIPECRSMNFSIYEGMLNRYKDSEDIRKSYESRGLNGLEVIRA
                     GEPDEGKILPDMVNGVHLYFHIFWMDWWKGNYERLDQEFDSREQWLEYFGGMSRESYLN
                     SLRDDLAYAEQVGAKYVVFHVSEVTLRESYIYKYRYTDKEVIDASLEVINTLLDEKEYP
                     FDFLVENLWWSGLTLKNVRLTRRLIEGMHTQKKGIMLDTGHYMNTTTQLKTPEDAIAYL
                     NKMIDKYEKAQMLHWFKGMHLQLSLGGDYVRKQRKEWREHPIDFDKIPFYELFRLAYDH
                     ACHIDLHQPFIGEGVREFVERVAPKYITLEYQQNSREEYEQFVETQSKILKWITIH"
     CDS             complement(9362..10336)
                     /locus_tag="ctg32_11"
                     /transl_table=11
                     /translation="MADWKSSQEFLKEFYASPIVNEDTISAKIKRIFLPKSRKASALKE
                     LAGDLSGEGRAGDVILDNDMFEMDTEIWKKQEKRRLSVRTRVSLFLLLVAIPLTIAVGF
                     YVMDVAAVGTVFEKIFGPRKYYFISLVIIIYSLLPFFMVFEGRKPQVRELVVLATMVAL
                     ATAGRAAFFMIPSFKPIIAIVIISAIAFGGEAGFLVGAMTMVVSNFLFGQGPWTPWQMF
                     AMGFIGFLSGILYRIGLLPTKRLSLCIYGFLVTVFIYGGIMNPAALFMSVYDFTWEGLL
                     AIYISGIPVDLVHASSTFIFLWIGAKPLLEKLQRIKIKYDLMR"
     CDS             complement(10340..12121)
                     /locus_tag="ctg32_12"
                     /transl_table=11
                     /translation="VTANGLSEKKNSILEINDLCFAYPEEKKRALNHASLHVEDGEFLV
                     LCGKSGCGKSTLLTHLKTPLTPHGKRKGEILFQGVPIGEMSNREQSQRIGYVLQNPDNQ
                     IVTDKVWHELAFGLESLGYSNADIRIRVAEMASYFGIQDWFYKNVSELSGGQKQLLNLA
                     SIMAMHPDMLILDEPTSQLDPIAASDFLETVKKINRDLGTTIILTEHRLEEVFPSADRV
                     VVMDEGQILCVGTPPEIGEELKKRNHEMFLAMPVPMQVYAKVESEQPCPITVRDGRKWL
                     DIVCKKKGISPANASSSYRKESDSQKGKSSFAKITEKFTEKKEDIILACDDLWFRYDKE
                     LPDVVKGLSFSLKRGEFFALLGGNGTGKSTTLSLLSRLRKPYRGKVLLEGKDIRRYSDK
                     ELFRNFLGVLPQNPQSLFVKKSVELELFEMVGGVKEKKDEEYQLAMDKKDAVEGIIKVT
                     HLEELLHRHPYDLSGGEQQRLALAKILLLRPKLLLMDEPTKGLDSYFKKEFAGILALLK
                     EQGVTVFMISHDIEFCASYADRCGLFFDGNIVACGTPGEFFAGNNFYTTAANRMARRYF
                     PMAVTGEDVVECLKKGV"
     CDS             complement(12163..13038)
                     /locus_tag="ctg32_13"
                     /transl_table=11
                     /translation="VTMFVVHPVILAISFICAVAYSVVLKGWKKTVKFNLLFSLPMMII
                     VALINPMFNHYGVTIIGYLHNGNPFTLESCVYGLVMAVMLVCTLVWFSCYTVVMTSDKF
                     IYLFGRIIPALSLVLSMCLRFVPKFIKEASVISDGQKCVGRSVENGSLIKRAKHGITIF
                     SILVTWSLENAIETSDSMKCRGYGEKGRTAFSLYHFDKRDFLCLIFMIITFGAAMWGFS
                     KGYAFCSYNPRIVVKGVPFTAGSLLVFAAFLLFSIMPAAMEILDRRMWKARRGQVESAA
                     PAGYRLWEVE"
     CDS             complement(13181..14506)
                     /locus_tag="ctg32_14"
                     /transl_table=11
                     /translation="MKKEKGLVYVVLALLMSMLLIVSTGCGKSGSGDSSSDKKMDKTET
                     LADVNNIPEDGVITKEQFKTVAGENKKVQFKGTTDDGITYIWTYDCSKIQNPADQNLKI
                     DFSEKDLDDLKKQANNANDALKMTMYGKGLICVPDLEVQLPEAWQSNSAYLVKEQSGKL
                     ARMSDVVVTAQVKEENKKKQDTKTEEKDSSDKTAKSTTQAKKDTKPKEGTTSLKMSVTS
                     LDGDCYIIGGITEQQNKGAASANKAENGTTNSESEGSDESGNSGENSYNEEGSSGSGDV
                     SDGGASSSGSSGKQDVANDEEVSGSSHTCTISISCATILNNMSDLKSGKEEFVPSDGWI
                     LAASEVEFTEGESVHDVLQRVCKDAGIQMESSFTPAYNSAYVEGINNLYEFDCGQLSGW
                     MYNVNGWFPNYGCSKYTVQDGDVINWVYTCNLGKDVGDNSMY"
ORIGIN
        1 tatgataaat tagcatccac ttttgcagca tttatatgca tcgcctcaat attaatttgg
       61 ttaaaatgaa caacttaaaa tgtttttcaa acacgctcta ggatgcagac agatattatg
      121 ttatccaaaa acaataacat acttattatt gatgccaaat attattcgca tatgacccag
      181 caacaatacg gaatacatac tctgcattcc aataatcttt atcagatttt tacctatgta
      241 aaaaataagg aatttgaatt gagaaactat gaacatactg tatcaggaat gcttctttat
      301 gcacaaaccg atgaagatat tattcctaat aacacctacc atatgagcgg aaatcagatt
      361 tctgttcttg cattagattt aaaccaggat ttttcaaaaa tctccagaac tttagatgac
      421 atcgccaaaa attttcttta aaatttttaa aggaagggac ctaatatccc ttccttactt
      481 ctattacccc tattgtaaca aaaaatctat aaacttcctc ataaagcgaa gaaccaaaat
      541 ggatacacct atagctgccg ctatacatac aattgaaaaa aacatctgaa aaatcacctg
      601 actatccata gcatatgaaa ctgcgttatt cattgtatct ccccctgact atcttttgat
      661 acttcatttt accatatctc tgtattttta tcaaaaattt ttcattttaa aaattacatt
      721 ttttatattt ttttacattt attagttgtt tttcttctta aatatgatat actattcctc
      781 accagttgta tcaccgagtt cttgacacac gtatactata cgtattataa tataattata
      841 gaaaggggtg gcatactatg ccaatgaaac caaaagaaat gataagatta ttaaaaaaaa
      901 atggtttcat aaaaataagt caaaatggtt cccatgtgaa aatgaagaat tttaaaactg
      961 gcaaacaaac aacagttcct cttcatagca aagatttaaa aaaaagacta gaagatgcca
     1021 tcctaaaaca agcgggctta aaatagcctt atttcatcta taataactca catacattgg
     1081 aggtatccat tatgaaaaaa ttattttatc ctgctgtatt tcatattgca gaagaaggcg
     1141 gttattgggt gacttttcct gactttcccg aatgtctaac tcagggagaa aatatgcaag
     1201 aagcctatga tatggctata gatgctttag gacttatctt aactgatgac attaacgacc
     1261 ataaagaact tccagaaccg tctaacatca cacatgttga tgatggagtt gtcgtaatca
     1321 tcccatatga ttatttggaa tataatcgaa agtatcataa taaatctatc aaaaaaactt
     1381 taacaatccc tgaatggttg aataacgaag cattgcgatt gaatttaaac ttttcacaga
     1441 ttttgcagga tgctctttta aacaaaattc aatctcgtta atggctataa ttctttcatt
     1501 tggtaatact gcaatcatag attataatat acttaacaag gcagctaata cgatagcttc
     1561 acctatccat ttccggcaag tttaggttaa aaaacagaac ccccacaact ttatagatag
     1621 caaatgtgat gtcggagcaa gtaaaaatgc ggctgagcat tttctacgca gcgaaatctt
     1681 cacatgtgct atctataaag ttgcgggggt tcgtctgttt ttaatctaaa tcaatccaat
     1741 cctacaccgg atatgctcca ttctttacat cggcttttgc aggatcaatc ttattctcct
     1801 gtgccgctct gtatttaaag aattcggttg ctacctgtgg gaacaatgcg tatgtaagca
     1861 catcttcgtc ctgttctttc cactggctca tctctgcctc gatcttagat aattccggtt
     1921 caagaaggtc ggctggacga caggtaattg gcttttcatc gccgattgcc tttttctgta
     1981 cttctttatt cattggtttt acggtttgac cgtattctcc acgaagaagg gcttttgact
     2041 cgtttgtaat cattttataa cgctctccgg taagtacatt taatacagcc tgtgttccga
     2101 caatctgact ggacggtgta actaatggtg gttcaccgaa gtctttacgt acttttggaa
     2161 cttcctctaa tacttcatag aacttatcgg atgctccctg ctgctctaac tgagatacaa
     2221 ggttagaaag cattccacct ggaacctgat acattaaagt cttgatgttt acaccaagta
     2281 cctttggact cattaagcca tttgcaatgt atttctcacg gatcggacgg aagtaatctg
     2341 cgatttcacc taaaagcttc tggtcaaatc ctgtgtcaaa ttctgtacca cggaatgtct
     2401 ccgccataac ttctgttgcc ggctggcttg ttcccattgc aaatggagat atggctgtat
     2461 caatgatatc gactcctgct tctactgctt ttaagtaagt cattccaccg acaccacttg
     2521 tatagtgtgt atgaagttcg ataggaatgt ctgttgcctg ctttaatgca gttacaaggc
     2581 gagttgcttc attcggcact aaaagtcctg ccatatcttt gatacagata gaatctgctc
     2641 ccatctcttc aatattctta gcagtctttt tccagtagtc taatgtatat gcatcaccga
     2701 ttgtatagga gagggcgatc tgcgcgtgtc ctccctcttt ctttgttgca tctacagcag
     2761 tctgtaagtt tctaaggtca tttaaacagt caaaaatacg aataacatca attccgtttg
     2821 caatagattt ctgtacgaaa tattctacaa catcgtctgg atatggctta tatcctaaga
     2881 tgttctgtcc acggaataac atctgtaact ttgtattctt aaagccatct cttaatttac
     2941 gaagtctctc ccatgggtct tcctttaaga aacgcaggca ggcatcaaat gttgcacctc
     3001 cccagcattc tactgcatga taaccaacct gatccatctt atctacgatt ggcagcatct
     3061 cctctgttgt cattcttgta gcaatcagag actgatgtgc gtcacggaga acggtttcta
     3121 ctattttaac cggttttttc ttaatttcgg ccataatatc tccttttatt tcaaatcacg
     3181 taactatttg cgcttacaac tgttattatc taaaattcaa cttgtaaact atttataaat
     3241 atcccctgta acatttttta cagattgtag ccctataaat aatgaatttt aaataatcaa
     3301 ataattctaa attatactcc aaaaattgcc ataaatgttc cggcggctac cgctgtaccg
     3361 ataactccgg caacatttgg tcccatcgca tgcatcagta agaagtttga tggatctgct
     3421 tccgcaccaa ctttctggga tacacgggct gccataggaa cggcagatac cccggcagaa
     3481 ccaattaatg gatttacctt accacctgta accttacaca taagtttacc aaacaggaca
     3541 cctgctgcag taccaacagc aaaagctaca agacctaata ctacaatctt gattgtgctg
     3601 acatttaaga atgcctctgc acttgttgtc gcaccaacgg atgtaccaag aataataact
     3661 acgatgtaca taagagcgtt agacgctgtc tctgaaagct gttttactac gccggactct
     3721 ctaaaaaggt taccgagcat cagcatacca actaatggtg ctgttgtagg aagaatcaga
     3781 catacaacaa ctgttacaac gatagggaac ataattttct ctgtttttgt aacggttctt
     3841 aactgttcca tcttaatctg acgttccttt tctgtagtaa ggagcttcat gatcggtggc
     3901 tgaataattg gtacaagtga catataagaa tatgccgcta ccgcaattgg tcccattaag
     3961 tctgtctgcc caagctttcc ggcaaggaaa atagaagtag gaccatcggc tccaccaata
     4021 atggaaattg ctgctgctgc ctttccgtta aatcccataa gcattgcaag gaaatacgcg
     4081 ctgtaaatac caaactgcgc cgcagctccc agcaagaaac ttgctggatt ggcaatcagc
     4141 ggaccaaagt ctgttagtgc tccaacacct aagaaaatca gtgaagggag aatactccat
     4201 tcatctaata agtaaaaata atgtaataat ccgccttctt ccataatgga cggatataag
     4261 ttaaccagca gcataccaaa agaaatcggc actaacaaaa gtggctcata tcctttggcg
     4321 atggccagat ataagaagac taaagcaacc agtatcataa tgaagttacc tggctttaag
     4381 aatgcaaatc cggtctgtgc tgcgagattc gtcattgtct ctacaacata actcataaat
     4441 cttcctccgt tttattttgc aaatatgctc tagttcattg tagccagtac atctccgcct
     4501 tctaccatat ctccaactgc tacttccaca cttgcgataa caccatcctg tgctgcacag
     4561 atttcattct ccatcttcat agcctctaat acaagaacag cgtcgccctt ctttacagaa
     4621 gcacctgcct gtgcctttac tgctacgatc ttacctggca ttggtgctgt aatctttacg
     4681 gcaccggcac ttccggaagt ctttggggca gctttcttag ctggagccgg aacggctgct
     4741 ggtgtactta ccggcgctgc acttgcttct cctgcaccta attcttctac tgctacatca
     4801 taagcaacac cattaactgt aattctataa tttttcattt taaatcctcc tgaatgattt
     4861 tatgtacttc taaaatcttt ctatagctaa cttttcaaaa ctttataaaa agattccaag
     4921 aatacatttt tgctatcttc tcttcactct cttgattgaa cgaacgacca acttatctgc
     4981 actgactgct gctcctccat tcgctgccat gattgccgct gtgattactg cgacaagttc
     5041 accatcatcc acaagttcct cttcttccac aacttcttca agaatcggac gctttggagc
     5101 cggtctttct tcctgcgcag cctttttctc tttcttagaa gaacgattct ttaacgctct
     5161 ttcaatagat gggatatata caaaaagaga aatcagtaaa gaaatgaaaa tcagtactgc
     5221 aaatacagtt cccataccca tcaaagtatt taataaggct tgttcaaata cgttcatact
     5281 ctcacctcac tatactgccg tatgcttctt tgtcactgga gttactttct ttccgtaaag
     5341 catttcataa gcagcgataa gacgctttct tgttgcgtcc ggctcgatga tgtcatctat
     5401 atatcctctc tttgcagctg ctaatgcact gctctgtcct tctgcatatt ccgcagtttt
     5461 ctctgcgata agtgctgtct tattcttatc tgtattgatt tcctctgcat acatgatacg
     5521 aactgcctgt tctgcatcca tcattcctac agatgcctgt ggccatgcca gaacaaagtc
     5581 agctccgata gctttagaat tcattacttc cgctgcagtt ccataagcct cgcctgcaat
     5641 gagattaata cgaggtacac taacctgtgc aagtgttgtt gtaaacttcg ctaatgcgag
     5701 cgcctgcttt ctctcttcat gtgcgttggc acgaagtcct gtcacgttcg ttacagtaag
     5761 aagaggaatc gaaaatgcat cacagaactt aataaatctt tctgcttttt caagaccatt
     5821 tcttgttaaa acggactcac catctactgg ctggttggca accgcaccta ctgtctctcc
     5881 attcagacgg ataaatgcag ttaccatctc tttggcatag gctgcctttg tctctatgta
     5941 catattgttg tcagaaatag attttaaaat gtaagcggca tcatatgcgg catcatttaa
     6001 ctcaggaata accctattta aatcatcatc gttatcaaag taaacatctt ctgcttcata
     6061 atcagaagga agtacatcaa cgagaatacg aagctggtca agaagtcctt cttctgtctc
     6121 acatacaaaa tctacgttac cagcctgctc agactggaac tgtgctcctg ccgtattctg
     6181 acgggattct tcattccccg ctaatgcatt cggactgttg ataaagagac tgccgttctc
     6241 cttctccatc aatgtaaaat cagacatagc ggacattacg gcacttcctc ctccacacat
     6301 tccaaatact gcagaaatct gtggaatcat tccagatgcc tgtgcctgct tattaaaaat
     6361 cgttccaaat gcgtgaaggg catctgtcgc ttcctgtaat ctaagtcctg cacaatccag
     6421 cattccaatg actggcgcgc ctgttttcat cgccagatca taaagggaag caattttctt
     6481 cgcatgcatc tcacctacgg aacctccaag tgcggaagca tcctgactgt aaacataaac
     6541 catgcggtca ttaataactc cgtatccagt gataacacca tcaccttcta ctttctttgc
     6601 accgagatta taatcggtat tacgagcgga aacatatcca ccaacttcca caaaactgtg
     6661 gtcatcaaac agataatcaa tgcgctctct ggcattcatt tttgaattac ccatattctt
     6721 tcctccataa aaatgctata ttgtatacct tgttgctctt tcattctatg taataataac
     6781 aaattattat catgttagca accattttct gttagttatt taacatttat tttattttgc
     6841 ccattccact aaacaaaatg agcattctgc ctatttgcaa attttttaac aattctttca
     6901 attttctttc tgaatctcct gtttttttca ggaacgcttg tgtatttttc ctgtttttct
     6961 ctattttatc tttaaaattc tatttttgtt ttatatgtcc atttttattt cgttataatt
     7021 ttaacgtatt ttgacattca attactagtt ggtttttcta ttttttcgtc attttataca
     7081 aaatattctc attctatcaa atatcttccg tttttcttca taatttcact cttatttcca
     7141 tcattcttct tttctcgctt atattctcct cctgtctttt ttaaatcaaa gatatagtat
     7201 ccaaaatcaa ttttgaacta tttttgtcaa acttttttca caaactaata gcgctccctt
     7261 tcattttata caactgtata tgcataccat gaagtatttt caaaaaatca gaaagaaatt
     7321 ataaactgtc aagaaaagcc tgtaattttg cacaaatact cctttatttt ttcacacaaa
     7381 aaaggtataa taaacaaaat aaacaattct ttcacaataa aggaggagga catcttatgg
     7441 aaaaccgcaa aattcaattt cgttcaaaag cctgtaatct acatctttct gcctatccgg
     7501 gacatttcgc aacaaagcat tctcatgtca actacttttt agatatgaca acattaaaag
     7561 tacgtcagtc taatgcagaa gaagctgcaa gagcgttagt tccactttat aaacataata
     7621 ccgtcgtcga taccatcgta tgtcttgacg gaacagaagt aatcggtgca tttttagcag
     7681 aaaagcttac agagagcgga ttcttctctt acaaccagca taaatctatc tatattgtta
     7741 ctccagaaat agattcagat ggtcagatgt tcttccgcaa aaacatccag ccaatgatta
     7801 aagatagaaa tatcattatt ttaatggcat ctgtcacaac tggaatcaca atcaaccgaa
     7861 gctgggaatg tatcgagtac tatggtggca aactgcaggg aatttcagca atatttagta
     7921 cgctttctga atatggtaat cttcctgtta atgcgctgtt tactccaaat gatattccta
     7981 cttaccatac atatgataag catgactgcc catattgtaa gagtggtcag aaaatcgatg
     8041 ctttggtaaa cggacatgga tattccgaat tactataact actaatttgt agatttcgta
     8101 tagacgaaaa aaagaaacca taccatatcc cagatgcgga tgagcatttt aaacacaacg
     8161 actacagagc agatgggata tggtatggtt tcttttttcg tctgttttct cttaatgaat
     8221 cgtaatccat ttcaaaattt tactttgggt ttctacgaat tgttcatatt cttcccggct
     8281 gttttgctga tattccagcg tgatatactt tggtgctacg cgctctacaa attcccggac
     8341 accttctccg ataaaaggct gatgcagatc aatatgacag gcatggtcat atgcaaggcg
     8401 aaatagttca taaaatggaa tcttatcaaa gtctatcgga tgttctctcc attcttttcg
     8461 ctgctttctt acataatccc ctcccagtga caactgcagg tgcattcctt tgaaccagtg
     8521 gagcatctgt gctttttcgt atttgtctat cattttattc agatatgcta tggcatcttc
     8581 cggagtcttt agctgtgttg ttgtattcat ataatgcccg gtatcgagca tgattccctt
     8641 tttttgtgta tgcattcctt ctataagccg gcgggtaagg cggacatttt tcaaggtaag
     8701 cccgctccac cagagattct ctacaagaaa gtcgaatgga tattcttttt catcaagtag
     8761 ggtattgatg acctctaagc ttgcatcaat cacttcttta tctgtatagc ggtatttata
     8821 aatatagctc tcccggagtg tcacttctga aacatggaaa actacatact ttgctccaac
     8881 ttgttctgca taggcaagat cgtcccgcaa actgttcaga taagattccc tgctcattcc
     8941 tccaaagtat tccagccact gctctcttga atcaaattcc tgatctaggc gttcataatt
     9001 ccccttccac cagtccatcc agaaaatatg aaaatacaga tgtaccccat tcaccatatc
     9061 cggcagaatc tttccttcat ctggctcgcc tgcccgaatc acttccagtc catttaatcc
     9121 tcgtgactca taagactttc taatatcttc actatcttta taacgattta gcatcccttc
     9181 ataaattgaa aaattcatgg aacgacattc tggtattttc tgcatagttt cccccttcaa
     9241 tctcgtatac tctcagaatc tttctaagaa tacattttat ctatacttat catccatact
     9301 tatttcaaaa atgccccatc attctggcaa tctttctaaa gttcaaaaac gccccggcta
     9361 ttcatctcat cagatcatat tttattttta tccgctgcag cttttccaac aatggctttg
     9421 ctccaatcca cagaaaaata aatgtagaac tggcatgaac aagatctacc ggaatacctg
     9481 aaatatagat tgcaagcagt ccttcccatg taaaatcata cacactcata aagagagccg
     9541 ctggattcat gattcctcca taaatgaaca ccgtcacaag gaatccatat atacaaaggc
     9601 tgagccgttt ggtcggaagc agtcctattc ggtaaaggat tcctgacaaa aatccgataa
     9661 aacccatcgc aaacatctgc catggggtcc atggtccctg cccaaataag aaattgctga
     9721 ctaccatcgt catggcacca actaagaatc ctgcctcgcc gccaaatgcg attgcactga
     9781 tgatcacgat tgctataatc ggcttaaagc tcggtatcat aaaaaatgct gcccggccgg
     9841 cggttgccaa tgctaccatt gttgcaagaa caactagctc tctcacctga ggttttcgtc
     9901 cctcaaatac cataaaaaac ggtaataacg agtatataat gattaccagg ctaataaaat
     9961 aatactttct tggaccaaaa atcttttcaa atactgtgcc aacggcggca acatccataa
    10021 cataaaatcc gacagcaatt gtgaggggaa tcgctacaag caagagaaag agacttactc
    10081 tggtacgaac agaaagcctg cgtttttcct gctttttcca gatttcggta tccatctcaa
    10141 acatatcatt atctaaaatg acatctcccg ccctgccttc tcctgacaaa tctcctgcta
    10201 attcttttaa agcagaagct ttcctgcttt ttggtaaaaa gatacgcttt atctttgcag
    10261 aaatcgtatc ttcattcacg attggagaag cgtaaaattc tttcaagaac tcctgacttg
    10321 atttccagtc tgccattgtt cacactcctt ttttaagaca ttccacaacg tcctccccgg
    10381 taaccgccat gggaaaatac cttctagcca ttcggtttgc cgctgttgta taaaaattat
    10441 ttccggcaaa gaattctccc ggagttccac atgccacaat atttccatca aaaaataaac
    10501 cacatcggtc tgcatacgaa gcgcaaaact caatatcatg agaaatcata aaaacagtta
    10561 cgccctgctc tttgagtaat gccagtattc cggcaaattc ttttttaaaa tagctgtcaa
    10621 gtcctttggt cggttcatcc atcaacaaaa gctttggccg caataacaaa atcttagcca
    10681 gggcaagcct ctgctgctct cccccgctta agtcatacgg atgacgatgc agtaattctt
    10741 ccaaatgtgt tactttaatg attccttcca ccgcatcctt tttatccatg gcaagctgat
    10801 attcttcatc ctttttctct tttacaccgc ctaccatttc aaacagttct aattccacac
    10861 ttttctttac aaaaagggac tgcgggtttt gcggcagtac tccaagaaaa ttgcggaaca
    10921 gttctttatc gctgtaacga cggatatcct taccttctaa aagtactttt ccacgatatg
    10981 gctttctcaa acggctcaaa agtgaaagtg ttgttgactt cccggttcca tttcctccaa
    11041 gcaatgcaaa gaattctcct ctttttaagg aaaagcttag tccctttacg acatccggca
    11101 gttctttatc atagcggaac cacagatcat cacacgctaa gatgatatct tcttttttct
    11161 ctgtaaactt ttctgtaatc ttagcaaaag aagattttcc tttttgggaa tcactctctt
    11221 ttctatatga agaagatgca tttgctggtg aaatgccttt tttcttgcaa actatgtcca
    11281 gccactttcg cccgtcacga acagtaatcg ggcagggctg ctctgactct actttggcat
    11341 aaacctgcat cggcaccggc atagctaaaa acatctcatg attgcgcttc tttaattctt
    11401 ctccgatttc cggcggtgtg ccaacacata aaatctgccc ttcatccatg accactaccc
    11461 tgtcagcaga aggaaatact tcctctaaac gatgttccgt aagaataatt gtcgttccaa
    11521 gatcacgatt aatcttcttt actgtttcca aaaaatcaga agctgcaatc ggatcaagct
    11581 gagaggtcgg ctcatcaaga atcagcatat ccggatgcat ggccatgata gatgccagat
    11641 tcaaaagctg tttctgtcct ccggaaagtt ccgatacatt tttataaaac cagtcctgaa
    11701 tcccaaaata acttgccatt tccgctaccc ggatacggat atctgcgtta ctgtatccaa
    11761 ggctttccaa accaaatgcc agctcatgcc acactttatc tgtcacgatc tgattatccg
    11821 gattctgtaa tacatatcca atcctctgac tctgctcccg gttactcatc tccccgattg
    11881 gtactccctg aaaaaggatc tctccttttc gctttccatg cggcgtcagg ggagtcttta
    11941 aatgtgtcag aagtgtactc tttccacatc cactctttcc gcaaagaaca aggaattccc
    12001 cgtcctccac atgcaaagaa gcatgattta gcgccctctt tttttcttct ggataagcaa
    12061 aacacaaatc attgatttct aatatactat ttttcttttc tgacaaacca ttcgctgtca
    12121 ccctgcacct ccaaacttgc tttttatctc ctgtatatac ggctattcaa cttcccacaa
    12181 acggtaccca gccggtgctg cactttctac ctgtcctctt ctcgccttcc acatccttcg
    12241 gtctaaaatc tccatcgctg ctggcatgat actaaacaat aaaaaagcgg caaagacaag
    12301 caggctgcct gctgtaaagg gtactccctt tacaacaatc cgaggattat aagaacaaaa
    12361 tgcatacccc tttgaaaagc cccacatcgc tgctccgaat gtaatgatca taaaaataag
    12421 gcacaaaaaa tcccttttat cgaaatgata taaggaaaag gcggttctgc ccttctctcc
    12481 atatccccgg cacttcattg aatccgatgt ttcaatcgca ttctccaaag accaggtaac
    12541 cagaatcgaa aaaattgtaa ttccatgctt tgctctctta ataaggctcc cattctctac
    12601 acttcgcccg acacactttt gcccatcaga aataacagat gcttctttga taaacttcgg
    12661 tacaaagcga aggcacatgg aaagtactaa agaaagtgcc gggatgatcc ttccaaaaag
    12721 ataaataaac ttatctgatg tcataacaac tgtgtagcag gaaaaccata caagagtaca
    12781 taccagcatc actgccatca caagaccgta cacacaactt tctaatgtaa acggatttcc
    12841 attatgaaga tatcctataa tcgttactcc ataatgatta aacatcggat tgatcagggc
    12901 aacaatgatc atcatcggta atgagaagag cagattaaac tttactgtct ttttccatcc
    12961 ttttaaaaca acggaatacg caacagcgca tataaatgaa attgccagaa tcacaggatg
    13021 aacaacaaac atcgtcaccc cgattgtccc gcaaaaatac agcatattta aaacaggatg
    13081 atatgtcgaa aatgtatctt tcatctaaat caaatctcca ttacatcaaa tttctattat
    13141 attaaatctt tattatatca aatctctatt tcatacatcc ttaatacatc gaattatctc
    13201 caacatcctt accaagatta catgtataaa cccagttgat cacatcgccg tcctgtaccg
    13261 tatacttact gcatccgtag ttaggaaacc agccatttac gttatacatc catccagaaa
    13321 gctgtccgca gtcgaattca tacagattat taattccttc cacataagct gaattataag
    13381 ccggtgtaaa agaagactcc atctggattc ctgcatcctt acatacacgc tgtaatacgt
    13441 catgtacaga ctctccttcc gtaaattcta cctcggaagc tgccagaatc catccatcag
    13501 aaggaacaaa ttcttccttg ccacttttta aatcactcat gttattaaga atcgtcgcgc
    13561 agctgattga aatcgtacac gtatgggaag aacctgaaac ttcttcatca tttgcaacat
    13621 cctgcttgcc ggaagaacca gaagaagaag ctcctccatc agaaacatct ccacttcctg
    13681 aacttccttc ttcgttataa gaattctctc ctgaattccc cgattcatca cttccttccg
    13741 attcactatt cgttgttccg ttttccgcct tattcgctga tgccgcacct ttattctgct
    13801 gctccgtaat tcctccaata atataacaat ctccatccag tgaagtaaca ctcattttta
    13861 aagatgtcgt tccttctttt ggcttcgtat ctttctttgc ctgtgttgta ctttttgcgg
    13921 ttttgtccga agaatctttc tcttctgtct ttgtatcctg cttcttttta ttctcttcct
    13981 tcacctgtgc tgttaccaca acatcgctca tccttgcaag ctttccagac tgctctttta
    14041 caagatatgc agaattggac tgccacgctt ccggaagctg tacctcaaga tccggtacac
    14101 agatcagccc tttcccgtac attgtcatct tcaatgcatc attggcattg ttcgcctgct
    14161 tctttaaatc atcaagatct ttctctgaaa aatcaatctt taaattctga tctgccggat
    14221 tctgaatctt tgaacagtca tacgtccaga tatatgtaat tccatcatct gttgtcccct
    14281 taaactgtac ctttttattt tctccggcaa ccgttttaaa ctgctccttt gtaataaccc
    14341 catcttccgg aatgttattc acatctgcaa gtgtctctgt cttatccatc tttttatcag
    14401 aagaactgtc tccactcccg gactttccac agcccgttga aacaatcagc agcatactca
    14461 taagcaatgc caaaacgaca tataccagac ctttttcctt tttcataata gtaccctttt
    14521 tcctttctat tattataaat ttttatacga aagcttcttt atatccgctg tgaaataact
    14581 cagcattctt atattctaca cgatgctttt tcaccaacgc tactctgtat ctccacctct
    14641 gccaaacttc tttagcactc ctgcgatagc atgacgcttt ttatacaata caaagacaag
    14701 tacccctact acaactcccc cgattatata aaatattacc atccatttga taccttcttt
    14761 tttcgagcct gtatccgatg tctccgtatc ctcttgtgcc acctcatctt cgctttctgc
    14821 cgaattcgta tccggcacat aattatctcc gctaaaactc cagccacccg tcgtttcttc
    14881 tgccgcagtc ttctttttct ttgctgttgt tcccgttgct gccttcgcag aatttccgct
    14941 atttccggaa ggaagcttct ttgtagtccc tgatgcagcc ggaacagacg aacttacggt
    15001 gctgtttccg gaagtgaccg gtgctgtaac ccgcttcgtc tgacttcttg ttgttgctgt
    15061 tgtaggattt ttctttgctg ttgttgccgg tgcagttacc acaactttac aaattgcctt
    15121 ttttccactt ccatccttcg cttttaccgt aatcattgca cttccagctt tcttccctgt
    15181 cacctttccc tttgcattta ctgttgcaat ctttttattg gaagaagacc atttcactga
    15241 cttcttcgtg gcatttgacg gagaaaccgt cgcttttaac gtcttactct ttccttttgt
    15301 aagataaatc gtactataat ttaatcccac ttttattacc tttactttag aagctgccgg
    15361 ttttgtttct gtcttttttg ctgtcgttga agaagaattt cctccactat tactccccgt
    15421 atcaatcgtc ggactgacta ccggcttcgt tcctgccgaa atagccacat cactcatatc
    15481 ataaagaaat gtctctccat ccaaaaatct acggtaagca actgttgcat acaatccctg
    15541 ttccgttgcc attccatcga taatgccacc ggcaccgcca ccattattcc cggcatcagc
    15601 agctacatgc ataaatcccc cttctggcat ataatactgg aataatcctg tcatcggcca
    15661 tttcccattc ttaataaaac gggcatcttc tccacaatct attcccacac cgcaaagagc
    15721 tgtgataatc tgtgccacac tttccgaagt ttctgtattc atcgtgccaa aaccaccact
    15781 ggaaagctga ttcttttcta tccatgcaag tcccttgtca attgccgctg taacatcctc
    15841 atatccatct ttattataat aagaagccag cgcctgcatc gccattcctg tcatatcgga
    15901 atctccagtt gttcccatca atgtccagcc accatcctga cactgcatcc ctacaacctt
    15961 cttaacaagt aactcctctg agttttgctg cactgcagaa gggtcttctg gaatctcata
    16021 tgccggatta ctctttaatg caatcaacgc ccaaatcgtg ccattattcc cctgtctgct
    16081 tacattctca taatctgaca gatacgctaa cagattatgt cccatcacat ttcttgcatc
    16141 gacaccaatc gctgttaatg caagaataag ctttgaataa tccgaatact ttgctcttgt
    16201 aatctgccag tccttactct cacagtatgc gatcacatta ctataaaaaa gatttatata
    16261 agattccggc acatacagcc cactcctttt taaaccaata acattccata tgctactgta
    16321 atccggcttc gtatctttac ttaagatata gcttcttacc ttagataaaa ccgtatcaat
    16381 atccggactt aagacttccg cctctgcttc cgtctgcact gccactcctg attcatcaga
    16441 ctgtccctgt gccgcatctt cctctgcacc ccaagcataa aaaccataac ttcttccaag
    16501 ctgcaaattc ttacggacaa tctttctctc tttttttgtt aatgtctgct cttgtgtact
    16561 ttcctgtaca tctgcctctg tacttgctga tgcatctgca tcttccctgg tctgctgctc
    16621 ctcctcttcc gaagactccg tctcctccct ttctgatgtc tcactttctg acgtctcact
    16681 ttctgacata gaaaaatcgc ctgtactctc tgca
//
