LOCUS       gnlProkkaJPAADKMP_9    15226 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JPAADKMP_9.
ACCESSION   gnlProkkaJPAADKMP_9
VERSION     gnlProkkaJPAADKMP_9
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 00:56:01
            Original ID  :: gnl|Prokka|JPAADKMP_9
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15226
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15226
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[4875:5226]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4876..5226
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..15226
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..15226
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             2..196
                     /locus_tag="ctg9_1"
                     /transl_table=11
                     /translation="MTAYEIAGKGLACEDSFRQAIYVAIDVFRNRQREKVARANPLRKQ
                     YYEKRDDSDKLKLDTVDED"
     CDS             206..1447
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 387.1; E-value:
                     2e-117)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg9_2"
                     /transl_table=11
                     /translation="MTRAEIQQVKQRFGIIGNTEALSRAIDVAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EADGGTIFLDEVGELPMPTQARLLRVLESGEFIKVGSSKVQKTDVRIVAATNVNLTQAI
                     AEGRFREDLYYRLNTVPIQIPPLRERGDDVLLLFRKFSADFAEKYRMPAIQLTEDAKKE
                     LLAYPWPGNVRQLKNITEQISIIETNREISAAILQNYLPAQNTQRLPALMGTRESKGFE
                     SEREILYSVLFDMRQEVAELKKMVHNLMAERAGQVGQVGQMGTVVTTPVVTAHQPSVPA
                     IIHTMQPTVCKDDDDIQDTEEYVEESPLSLDEVEKEMIRKALERHHGKRKSAAKDLNIS
                     ERTLYRKIKEYELD"
     CDS             1434..1961
                     /locus_tag="ctg9_3"
                     /transl_table=11
                     /translation="MNWIKKIIRPLLLFGLPLVVIACTVSYKFNGSSINYDKVKTISIA
                     DFPIKSEYVYAPLATKFNEDLKDIFIRQTRLQLLKPSQNADLQIDGEITGYNQYNQAVS
                     ADGYSSETKLTITVNVRFVNNTNHAEDFEQQFSAFRTYDSTQLLTAVQDGLIAEMSKEI
                     TDQIFNATVANW"
     CDS             1967..2740
                     /locus_tag="ctg9_4"
                     /transl_table=11
                     /translation="MTSVNFQQWIQHPETLNRDTLYELRNLLARYPYFQSLRLLYLKNL
                     YILHDISFGGELRKAVLYIADRRQLFRLIEGDRYDVQARKKGVPLTEVLKDEPSVDRTL
                     ALIDAFLSTVPEEVTARTSFDYSMDYTSFLLEETPATEQPAEETPKLKGFELIDDFIEK
                     SESDSPLCMKPLREEMPSSPTSSDELTEEETIKEEEEDDSCFTETLAKIYVKQQRYSKA
                     LEIIKKLSLKYPKKNAYFADQIRFLEKLIINANSK"
     CDS             2747..3142
                     /locus_tag="ctg9_5"
                     /transl_table=11
                     /translation="MYLLFVILMVIAALLMCFIVLIQNSKGGGLASGFSSSNAIMGVRK
                     TTDFLEKATWGLAIFMVVMSIATAYVVPRSAVAKDAVLEQAQKEQQTNPYNLPAGTAAP
                     QTEAPATNAPATETPAPATETPAPAAE"
     CDS             3390..4778
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 92.3; E-value: 4.1e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg9_6"
                     /transl_table=11
                     /translation="MTEHLKQKLNDSAVLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE
                     KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACLLMVFGCGLKYY
                     AISTTFPEGAMLFGFKTQVTLAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL
                     EMATARIGTTLAMVLTVPLADFFGSTDESGTFHTNIPAPILFCLIMLCVGTIAFFLYTF
                     YDKKLDASLDAEGLEPEEPFRMKDIVYIITNKGFWLIALLCVLFYSAVFPFIKYAADLM
                     VQKYNVDPKLAGTIPGLLPIGAIILTPLFGSLYDRIGKGATLMIIGSVMLIFVHTMFAL
                     PILNIWWFATIIMIILGFAFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVP
                     LLIGWVLNTYCKGPVVDGAQTYDYTLPMTIFALFGVLALIVALMLKAENKKKGYGLEEA
                     NIQK"
     CDS             4876..5226
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg9_7"
                     /sec_met_domain="PqqD_RRE (E-value: 1.4e-10, bitscore:
                     34.4, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 5e-17, bitscore: 55.6,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAKEKINLLEVIPCRSEHITAEREGETIVLSFPRFKYPWMQRFL
                     VPKGMSKELHVKLEEHGTAVWELIDGKRNVREIIEKLADHFQNEEGYESRVSAYLSQMQ
                     KDGFIKLVIPVA"
     CDS             complement(5409..5693)
                     /locus_tag="ctg9_8"
                     /transl_table=11
                     /translation="MVGEGHAFDMIRRIKEGREASRLRRERANDKLKHLNRANEPYPLP
                     NTTPEEMERIIHDSEKKKEKDSNYFVWGTLIIMGVLIAIAVILWAVFIK"
     CDS             complement(5730..6797)
                     /locus_tag="ctg9_9"
                     /transl_table=11
                     /translation="MKKLIIAAGLLMTTSAYAQTEVLTGVTRGKDYGVVYSLPKTQIEL
                     EIKANKVNYTPGEFSKYADRYLRLTNVSADPEEYWELTSVKVKSVGVPNSETTYFVKLK
                     DKTVAPLMELTEDGIVKTINVPYSNSSVGKKAAPAPTVLQKKANPREFLTEEILMASST
                     AKMAELVAKEIYNIRESKNALLRGQADNMPSDGAQLKIMLDNLNAQEEAMTQMFSGTCN
                     KEERTFTVRLTPDKEFNNEVAFRFSKKLGVVANNDLAGTPFYISLKDLKSVKIPQEDGK
                     KKKDLDGIAYNVPGQAMVTLTDGKKKLYEGELPITQFGVIEYLAPVLFNKNSTIKVYFD
                     PNTGGLLKVDREEGK"
     CDS             complement(6870..8381)
                     /locus_tag="ctg9_10"
                     /transl_table=11
                     /translation="MKIFPSSSIKKLDAYTIENEPITSINLMERAATVLTKAITDRWNT
                     ETPVTIFAGPGNNGGDALAVARMMAEKGYKIEVFLFNTKGELSPDCQTNKELVEMMEEV
                     KFHEISTQFVPPALTPDHLVIDGLFGSGLNKPLSGGFAAVVKYINSSPAMVVAIDIPSG
                     LMGEENTFNVKANIIRADVTFSLQLPKLAFLFAENTEFVGEWEVLDIQLSEDGIEEMET
                     NYEMLEIEEIRSLIKPRKQFAHKGNFGHALLIAGSKGMAGASVLAARACLRSGVGLLTV
                     HAPMCNNDILQTSIPEAIVETDINETCFAVPTDTDDYQAVGIGPGLGRNEETEAALLEQ
                     LEHCLTPVVVDADALNILANHRHALTHLPKGSILTPHPKELERLTGKCQDSYERLMKAC
                     ELARAAHVHIILKGAYSAIITPEGKCFFNPTGNPGMATGGSGDVLTGVILALLAQGYPT
                     EEAAKIGTYIHGLAGDVAQKKQGMIGMIASDIITCLPTAWRLVSE"
     CDS             9444..9668
                     /locus_tag="ctg9_11"
                     /transl_table=11
                     /translation="MMEKTKIGLNAGKVWRILNEKGELSMFDLCRELSLTFEDVALAIG
                     WLAREDKIFLRKREGMLFASIENVEFTFG"
     CDS             9873..11417
                     /gene_functions="transport (smcogs) SMCOG1202:major
                     facilitator transporter (Score: 47.5; E-value: 1.6e-14)"
                     /gene_kind="transport"
                     /locus_tag="ctg9_12"
                     /transl_table=11
                     /translation="MSALKGHPKGLYLIFATSTAERFSYYGMRAIFILFLTQALLFDKE
                     AAASIYGSYTGLVYLTPLIGGYIADKYWGIRRSVFWGAMMMAVGQFLMFMSASTLDNTE
                     LAHWMMYGGLGFLILGNGCFKPTVSSLVGQLYEPGDRRLDAAYTIFYMGVNVGSFAAPL
                     ICGYLGDTGDPHDFKWGFLAAGIMTLFTVVLFETQKNKYLFSPSGEPIGIIPDAKREKK
                     EDKAEHISHPKMDKRTKLRNTLVITILTVALIAFFNYAFEGDWVSIGIFTACIVFPVLI
                     LLDGSLTKIERSRIFVIYIVAFFVIFFWAAYEQAGASLTLFASEQTNRDILGWEMPASW
                     FQSFNPLFVVVLAYIMPGVWSFLNKRKMEPASPTKQAIGLLLLSLGYLFICFGVKDAIP
                     GVKVSMIWLTGLYFIHTMGEIALSPIGLSMVNKLSPLRFASLMMGIWYLSTATANKFAG
                     MLSGLYPEAGKVKSIFGYQIATMYDFFMVFVVMSGVASLILFLLSKKLQKMMHGVE"
     CDS             11459..11995
                     /locus_tag="ctg9_13"
                     /transl_table=11
                     /translation="MDTIQIKDKQFTVSIKEQDIQKEVIRVANEINRDLAGKNPLFLSV
                     LNGSFMFTADLLKHITIPCEISFVKLASYQGVTSSGVIKEVIGLNEDIAGRTVVIVEDI
                     VDTGLTMQRLLDTLGTRNPEAIHIASLLVKPEKLKVNLNIEYVAMEIPNDFIVGYGLDY
                     DGFGRNYPDIYTVVD"
     CDS             12063..12632
                     /locus_tag="ctg9_14"
                     /transl_table=11
                     /translation="MLNIVIFGAPGSGKGTQSERIVEKYGINHISTGDVLRAEIKNGTE
                     LGKTAKGYIDQGQLIPDELMIDILASVFDSFKDSKGVIFDGFPRTIAQAEALKKMLAER
                     GQDVSVMVDLDVPEEELMVRLIKRGKDSGRADDNEETIKKRLHVYHSQTAPLIDWYKNE
                     KKYQHINGLGTMEGIFAEICEAVDKL"
     CDS             12748..13914
                     /locus_tag="ctg9_15"
                     /transl_table=11
                     /translation="MAESNFVDYVKIYCRSGKGGRGSTHMRREKYCPNGGPDGGDGGRG
                     GHIILRGNRNYWTLLHLKYDRHAMAGHGESGSKGRSFGKDGADKVIEVPCGTVVYNAET
                     GEYLCDVTEDGQEVILLKGGRGGQGNWHFKTATRQAPRFAQPGEPMQEMTVIMELKLLA
                     DVGLVGFPNAGKSTLLSSISAAKPKIADYPFTTLEPNLGIVSYHGGKSFVMADIPGIIE
                     GASQGKGLGLRFLRHIERNSLLLFMVPADSDDIRKEYEVLLNELRTFNPEMLDKQRVLA
                     VTKSDMLDQELMDEIEPTLPEGIPHVFISSVSGLGISVLKDILWEELNKESNKIEDIVH
                     RPKDVTRLQQELKDMGEDEDIVYEYDDNVDDDDDDIDYEYEEEDWEEK"
     CDS             13911..14723
                     /locus_tag="ctg9_16"
                     /transl_table=11
                     /translation="MISLTKNNELKGYKSLDVYPEVAHFVTTRHEGISTGAYGSFNCSP
                     YTNDSCMNVNRNQSWLFQCMNHQIKELFIPEQSHGCASLIINESFFKESLEMRRLLLRG
                     MDALITNVPGYCVCVTTADCVSVLLYDKKQHVVAAVHAGWKGTVKHIVSHVMDHLNQKF
                     GTQGEDVVACIGPSISLESFEVGDEVYDAFKESGFDMSLISMKKKETGKYHIDLWEANR
                     IELLNAGVPAEQIEVAGICTYIHHDEFFSARRLGIDSGRILSGIMIRK"
ORIGIN
        1 gaggacggca tacgagattg caggcaaggg attggcttgt gaagattctt tccgtcaggc
       61 aatctatgtt gccatcgatg tgttccgtaa tcgtcagcgg gaaaaagtgg ctcgtgccaa
      121 tccgttgcgt aaacagtatt acgagaaacg tgacgatagt gataaactga agctggatac
      181 agtagacgaa gattaaaaac gagtgatgac gagagcagag atacaacaag tgaaacaacg
      241 tttcggtatt ataggtaata ccgaagcatt gtcgcgcgcc atagatgttg ccattcaggt
      301 agctcctacc gatttgtctg tgctgattac cggagaaagt ggagtcggaa aagaaagttt
      361 tccgcagatt attcatcaat atagccggag gaagcatgga cagtatattg ctgtcaactg
      421 tggtgctatt ccggagggca cgattgattc cgaactgttc gggcatgaga agggtgcgtt
      481 taccggtgcg attggcgaac ggaaagggta ttttggcgaa gccgacggtg gtactatttt
      541 ccttgatgaa gtaggggagt tgccgatgcc tacccaggcg cgtttgctcc gtgtgttgga
      601 gagtggcgag tttataaaag taggttcgtc caaagtgcaa aagacggatg ttcgtattgt
      661 ggcagctacc aatgtcaatc tgacacaagc gattgcagaa ggacgtttcc gtgaagattt
      721 atattaccgg ttgaatacgg tgcctatcca aataccgcct ttgcgtgaac gtggtgacga
      781 tgtacttttg ttgttccgta agttttccgc agactttgca gagaaatacc ggatgcctgc
      841 tatccagttg acggaggatg cgaagaaaga gttattggct tacccgtggc ccggcaacgt
      901 tcgtcagttg aagaacatca ccgagcaaat atctatcatt gaaaccaaca gggagatctc
      961 tgctgctatc ttgcagaatt atcttcctgc acaaaatacg caacgtcttc ccgcgctgat
     1021 gggaacgcgt gagagtaaag gctttgagag cgaacgggag attctttatt ctgttctgtt
     1081 cgatatgcgc caggaagtgg cggagctgaa gaagatggtg cacaacctga tggcggaacg
     1141 tgccggacag gtggggcagg tagggcaaat gggaacggtg gttactactc cggtagtgac
     1201 ggcacatcaa ccttcggtac ctgctatcat tcacaccatg cagcctacgg tttgcaagga
     1261 tgacgatgac atacaagaca cggaagaata tgtagaagaa tctcctttgt cactggacga
     1321 agtggagaaa gaaatgatac gcaaggcact tgagaggcat catggaaagc ggaagagtgc
     1381 ggccaaggac ttgaatattt ccgagcgtac actttataga aaaataaaag aatatgaatt
     1441 ggattaagaa aataatacgc cctttgctac tgttcggctt gccgttggta gtcattgcgt
     1501 gcactgtttc ctataagttt aacggatcgt ctatcaatta tgataaggta aagaccattt
     1561 cgatagccga cttcccgatc aagtcggagt atgtatatgc tccgttggca accaaattca
     1621 atgaggacct gaaagatatc ttcatccggc agacccgtct gcaactgctc aagccgagtc
     1681 aaaatgccga cttgcagatt gacggagaaa tcacagggta caatcagtac aaccaggcag
     1741 tatctgccga cggttattct tcggagacga agttgactat caccgtcaat gtgcgttttg
     1801 tcaacaacac caatcatgcc gaagactttg aacaacagtt ttctgcgttc cgtacctacg
     1861 actctaccca gttgttgact gccgtacagg acggattgat tgctgaaatg tctaaagaga
     1921 tcaccgacca aatttttaat gcaactgtag caaactggta atataaatga cttctgttaa
     1981 ctttcaacaa tggattcagc atcccgagac gctgaatagg gatactttgt acgaactgcg
     2041 caatcttctt gcgaggtatc cgtattttca gtcacttcgt ctgttgtatc tgaagaatct
     2101 gtatattctc catgatatta gtttcggtgg agaactgcgg aaagcagttc tttacattgc
     2161 agacagacgg cagttgttcc ggttgattga aggtgaccgc tatgatgtgc aggcgcggaa
     2221 aaagggagta cctctcacgg aggtgctgaa agacgaaccg tccgtagacc gcacattagc
     2281 attgatcgac gctttcttgt ccacagtacc cgaagaggtg actgcccgga ccagtttcga
     2341 ctattcgatg gattacacct ctttcctttt ggaggagact ccggccacgg aacagccggc
     2401 tgaagaaacg cccaaactca aaggcttcga actgattgac gattttatag aaaagagcga
     2461 gagcgactct cccctctgca tgaaaccttt aagagaagaa atgccatctt cgccaacctc
     2521 ttcggacgaa cttaccgaag aagaaacgat aaaggaagaa gaggaagatg acagctgttt
     2581 tacggaaact ttggcaaaaa tctatgttaa acagcaacga tattcaaaag ctcttgaaat
     2641 aattaaaaaa ttaagcttga aatatccaaa aaaaaatgct tactttgcag accaaatcag
     2701 atttttggag aaattgatta ttaacgctaa ttcaaaataa ctaaaaatgt acttattatt
     2761 cgttatctta atggttattg cagccttgtt gatgtgtttc atcgtgctga ttcagaactc
     2821 aaaaggaggc ggacttgctt ctggtttctc ttcatctaac gccatcatgg gcgtgcgcaa
     2881 gactacagac tttctggaaa aagcaacatg gggcctggcc atctttatgg ttgtaatgag
     2941 cattgctact gcttatgtag ttcctcgctc tgctgttgct aaagacgcag tgttggaaca
     3001 ggcacagaaa gaacaacaga ctaacccgta taacttaccc gcaggtacgg ctgcgccgca
     3061 aactgaagct cctgctacca atgcacctgc tacagaaact ccggcaccgg ctactgaaac
     3121 tcctgctcct gcagcagagt aattcactcc gtcgtcaagt aagactttgg ggtaaaacca
     3181 ttaatgggaa ggtgcagacg gatgctgcat ttctttgata tttaagtgcg gattacgcag
     3241 attacacgga ttttcaatgt tccgcgtggt cagtgtaatc cgcacttaac tttttcttgt
     3301 aaaaacaatc tctttgtgat agaaacaaac gagatttaac tacctttgtt ggctgtataa
     3361 gattattaac tactttttta aatataacaa tgacagaaca tttgaaacag aaattgaatg
     3421 actccgccgt actccgatgg agtgttctag cattggtcgc atttactatg ctatgcggct
     3481 atttcctcac cgacgtaatg tctcctctaa aacccatgct tgagaaagaa ctactatggg
     3541 acagtcttga ttatggtttc ttcacaagtg cttacgggtg gtttaatgta ttcctattga
     3601 tgctgatctt cggtggtatc attttggata agatgggagt tcgtttcacc ggaatggggg
     3661 cttgcttatt gatggtgttt ggttgtggat tgaaatacta tgcgatttct actacttttc
     3721 cggaaggtgc catgctcttc ggattcaaaa cacaggtgac gttggctgca ttgggatatg
     3781 ctatctttgg tgtaggtgtg gagattgctg gtatcactgt ttccaagatt atagtgaaat
     3841 ggttcaaggg caaggaaatg gcattggcta tgggacttga aatggctacg gcacgtatcg
     3901 gaacaactct ggcgatggta ttgacagttc ctttggcaga ctttttcgga tctacggatg
     3961 agagtggcac attccataca aatattcctg ctccgatttt gttttgtctg attatgttgt
     4021 gcgtgggtac gattgctttt ttcctttata ctttctatga taagaagttg gatgcttctt
     4081 tggatgcaga gggattggaa ccggaagaac cgttccgtat gaaagatatt gtgtatatta
     4141 ttaccaataa aggattctgg ttgattgcat tactatgtgt attgttctac tcggctgtat
     4201 tcccctttat caagtatgct gccgacttga tggtgcagaa atataacgta gatccgaagt
     4261 tggcgggaac gattcccgga ttgttgccga ttggtgcgat tatcctgact ccgttgttcg
     4321 gttcgcttta tgaccgtatc ggtaagggag ccacattgat gataatcgga tcagtgatgc
     4381 ttatttttgt gcatacgatg tttgctctgc ctatactgaa tatatggtgg tttgctacta
     4441 tcatcatgat tatattggga tttgccttct cgttggtgcc ttcagctatg tggccgtctg
     4501 ttccgaagat tattccggaa aaacagttgg gtaccgcata cgcattgatt ttctgggtac
     4561 agaactgggg attgatgggt gttcctttgt tgatcggatg ggtgttgaat acttattgca
     4621 aaggtccggt agtagacggt gcacagactt atgactacac gttgccgatg actatttttg
     4681 ctctctttgg tgtacttgct ctgattgtgg ctttgatgtt gaaggcagag aacaagaaga
     4741 agggatacgg tctggaagag gcgaatatcc aaaagtaact gggaaattca atacctaaag
     4801 taacaaagga attttgtatc aaggtgtaaa caaaagggta tcagtatgaa tactctgaaa
     4861 taaaaaataa gaagtatggc tgccaaagag aaaatcaacc tgttagaggt cattccctgt
     4921 cgcagtgaac atattacagc agaaagggaa ggggagacaa ttgtgctctc ctttccccgt
     4981 tttaaatatc cgtggatgca acgcttcctt gtgccgaaag gaatgtcgaa agaacttcat
     5041 gtgaaattgg aagaacacgg tacggctgta tgggaactga tagatggaaa acgcaatgtt
     5101 cgtgagatta tagaaaaact cgcagaccat tttcaaaatg aagagggcta cgagtcgcgt
     5161 gtatcggctt atctttctca aatgcagaaa gatggattta taaaactggt gataccagtc
     5221 gcataaatag gaatttatat ttcaccacag aggacacgga ggacacagag ttcttctctc
     5281 tctttccgca agtaaaacag agcgataaat acgattctca atacgtgaga ctctgtgtta
     5341 ctctatagtg aataaaaaag attaaacctc tgtgtcctcc gtgtcctctg tggtgaattt
     5401 attattattt atttgataaa tacagcccaa agtatgacgg caattgctat caggactccc
     5461 atgataataa gcgttcccca aacaaaataa ttgctgtctt tctctttctt tttctccgag
     5521 tcgtggatga tacgttccat ttcttcggga gtggtattgg gtagtggata aggttcgttt
     5581 gcacggttta aatgcttcaa cttgtcgtta gcacgttcac gacgtaggcg ggaagcttcc
     5641 cgtccctctt ttattcggcg tatcatgtcg aatgcatgtc cttcaccaac catattcttt
     5701 gttttttaga agttcacttt ctcgtttttc tatttccctt cttctctgtc cactttgagc
     5761 aatcctcccg tattcggatc aaaataaact ttgatggtag aattcttgtt gaacaaaacc
     5821 ggagccagat attctatcac accaaattga gtaataggaa gttcaccttc gtaaagtttc
     5881 tttttgccgt cggtcaatgt aaccatagct tgtccgggta cgttgtaggc gattccatcc
     5941 aaatctttct tcttcttacc atcttcctgt ggtatcttga ccgatttcag gtctttcaga
     6001 ctgatataaa acggagttcc tgccaaatca ttgttggcaa ctacacctaa cttcttcgag
     6061 aagcggaaag caacttcatt gttgaattcc ttgtcagggg taaggcggac agtgaatgtt
     6121 ctctcttcct tgttgcaggt gccggagaac atttgcgtca tggcttcttc ctgtgcattc
     6181 agattgtcga gcataatctt aagctgtgct ccgtctgaag gcatattgtc agcctgtccg
     6241 cgcaataagg catttttgct ttcgcggatg ttatagattt ctttagccac cagttcggcc
     6301 atcttggcgg tagagctagc catcagaatc tcttcggtca ggaattcacg aggatttgct
     6361 ttcttttgga ggactgtggg agcgggagcg gcttttttgc ctacactgct gttgctgtaa
     6421 ggaacattga tcgttttcac aatgccatcc tctgtcagtt ccatgagcgg tgctactgtc
     6481 ttatccttca attttacgaa atacgtcgtt tcgctgttgg gcacacctac ggatttcact
     6541 tttacgctag tcagttccca gtactcttca gggtcggcgg agacgttggt cagtcgcagg
     6601 taacgatcag catatttgct gaattctccc ggagtatagt tgactttgtt ggcttttatt
     6661 tcaagttcta tttgggtttt gggaagactg taaaccactc catagtcttt tcctcgggta
     6721 acccctgtca gtacttcggt ttgtgcatag gcggacgttg tcataagtag tcctgctgct
     6781 ataatcaact ttttcatatt cggttctttt taactggttt tgaaaacaaa gttaatgaag
     6841 ttattgaaaa aactgtaagt tcttaacttt tattcgctta caagtcgcca tgctgtcggc
     6901 agacaggtga taatatcgct tgcgatcatt ccgatcattc cttgcttctt ttgagcgaca
     6961 tcgcccgcca atccgtgaat gtaagtgccg attttagcgg cttcttcggt gggataacct
     7021 tgggcaagca gcgccaggat tactccggtc agtacgtcac cgctacctcc ggttgccatt
     7081 cccggatttc cggttgggtt gaagaaacat ttaccttcgg gggtgatgat ggcggagtag
     7141 gctcctttta aaataatgtg gacatgggcg gcacgggcca gttcgcaagc cttcatcaga
     7201 cgttcgtaag agtcctggca tttgccggtc agacgttcca gttcttttgg atgcggggtg
     7261 aggatggaac ccttcggcag atgggtaagg gcatgacggt ggttggcgag gatattaaga
     7321 gcgtcggcat ctactacaac aggagtcagg cagtgttcca gttgttccaa taaggcagct
     7381 tccgtttcct cgtttcgtcc cagtcccggg ccgatgccga ctgcttgata gtcgtccgtg
     7441 tcggtaggta cggcaaaaca ggtttcgttg atgtcggttt ctacgattgc ttcgggtatg
     7501 gaggtctgca agatgtcgtt gttgcacatt ggcgcatgaa cagtcagcag ccctactccc
     7561 gaacggaggc aggcgcgggc agcgagaaca gaggctcctg ccattccttt tgaaccggca
     7621 atcaatagtg catggccgaa gttccccttg tgggcaaact gtttgcgtgg cttgatgagt
     7681 gaacggattt cttctatttc caacatttcg tagttagtct ccatctcttc aataccgtct
     7741 tcgcttaatt ggatatccag cacttcccat tctccgacaa attcagtgtt ctctgcgaaa
     7801 agaaaggcga gcttcggcag ttgcagactg aaagttacgt cggcgcggat aatattagct
     7861 tttacgttga atgtattttc ttctcccatc agtccggaag gaatgtcgat ggctactacc
     7921 atagcagggg aggaattgat gtatttcact acggcagcga atccgccgct taacggtttg
     7981 ttcaggcctg aaccgaataa tccgtcgatt accagatggt cgggcgtcag ggcgggaggt
     8041 acgaattggg tactgatttc gtggaatttt acttcttcca tcatttctac cagttcttta
     8101 ttggtctggc agtcgggtga aagttctcct ttcgtgttga agagaaatac ctcgatttta
     8161 tatccttttt cagccatcat gcgggctacg gcgagagcgt ctccaccatt attccccggt
     8221 ccggcaaaga tagtgaccgg cgtttccgta ttccatctgt ctgtgatggc ttttgttaat
     8281 acggttgctg cacgttccat cagattgatt gatgtaatag gttcgttctc aatggtataa
     8341 gcgtccaatt tcttgatact gctgcttgga aatattttca ttgcgatgtt cttttagttt
     8401 tcggattaca aatgtacatg attcttctga cttttcccgt ttgttgtggg aagaaaacca
     8461 taattgcaac ttttaattca tcattagttc tatcttttgg tcaaagaaat atctgctttt
     8521 aaactattaa gtgttagaat aactccgcta aaaaataatt caatgctgca ccattatgaa
     8581 cttactttta tttctccctg aaaaagattt cttcatttca tttctcatat tctcattgtt
     8641 tttcgataaa cgaaagataa tcaaatagat atcttatgag aaacactttt tcaaaacggt
     8701 atttctcata agttctccca tgttttggct caaaagccac cttattctca tcgtatttca
     8761 gggtatttct catagtcaaa agccattctt tcttcctttt ttctttcagc ctgccttatt
     8821 tttatcagga aatgaagcta ctatttagat aaaatagtgg ctttttgctt ggagatgctc
     8881 gttgttctcg attgtcccat atattgtggg aaagtattct cgtatattga aggaaaactt
     8941 tcccacaaaa taagggaata ctttcccaag ccttagggaa tcttttccca caatatgtgg
     9001 gactaagaca ctgtgtatgg aagcaagcaa aaggaatata tagttctatt tattcaatgt
     9061 cagcttccgg cacgctacac tatgagaaat gaagcaaaat ccgggttatt ttgcgaagaa
     9121 actatgagaa atgcctgttt taaaatcatt tctcatagtc tatcttatta gtttactgcc
     9181 acttgtgcct tatttatgag aatatgagaa atgaaaatga aaaatctttt tctgtagagg
     9241 ggcggatgga aattgtgttt agtttatctc cataccttct taaacaaatt tttaatgcgg
     9301 ttcccttgat taagcctttg attatttgcc gtttccgata aaaatgttat ctttggagat
     9361 agataatgtg catcacatta atttcctgtg ctcacaatga attagaatct aaataacgga
     9421 ttgtttaatc ttctaaagtt tgcatgatgg aaaagacaaa aattggcttg aatgccggga
     9481 aagtatggcg catcttaaat gaaaaaggtg aactttcaat gttcgatttg tgccgtgaat
     9541 taagtttgac gtttgaagac gtagctcttg ctattggttg gctggcccga gaagacaaaa
     9601 tctttttgag gaaaagagaa ggaatgcttt ttgccagtat cgaaaatgtc gaatttactt
     9661 ttggctaagg tggtagctaa cctatattta agatggatct ccactttgtt atttacacag
     9721 ctaaaaaaat aatgaagtgg atcagtagga ttttttatgc ccatttttat tattccccct
     9781 atattcccgt ttgataagaa ctttcttttt ttgaagcatt taatctattt ttcgtacctt
     9841 tgcaccccat aaactactaa acacataaat tcatgagtgc attgaaaggg catccgaaag
     9901 gcctttatct gattttcgcg acaagcacgg cagaacgttt cagttactac ggtatgcgtg
     9961 cgatctttat tcttttcctg acgcaggcat tattgtttga caaagaagcg gcagcatcca
    10021 tttacggtag ctataccggg ttagtctatt taactccttt gattggcgga tacattgccg
    10081 ataaatattg gggaatccgt cgctctgtgt tttggggagc aatgatgatg gcagtcggac
    10141 aattcctgat gtttatgagt gcctctactt tagataatac ggaacttgct cactggatga
    10201 tgtatggcgg actcggattc ctgatcttgg gaaatggttg tttcaaacct accgtttctt
    10261 ctcttgtagg tcaactctac gaaccgggag acagacggct ggatgctgca tataccatct
    10321 tctatatggg agtgaatgta ggttcttttg ccgccccttt gatttgtggt tatctgggcg
    10381 ataccggtga cccgcacgat tttaaatggg gatttcttgc agccggaatc atgacactgt
    10441 tcactgttgt actttttgaa actcaaaaga ataaatatct tttctctcct tccggagagc
    10501 caatcggtat tatccccgat gccaaacgtg aaaagaaaga ggataaagcc gagcatatct
    10561 cacacccgaa gatggataag cgtaccaagt tgcgtaatac ccttgtaatc actattctta
    10621 cagttgcttt aatagccttc tttaattacg cttttgaggg tgactgggtg agcatcggta
    10681 tttttaccgc ctgcattgtt ttccctgttc tcatcctatt ggatggttca ttaaccaaga
    10741 tcgaacgtag tcgtattttc gttatctata tagtagcttt ctttgtcatt ttcttctggg
    10801 cggcttacga acaggcagga gcctctttaa ctctctttgc ctccgaacaa accaatcgtg
    10861 atattttagg ttgggaaatg ccggcttcgt ggtttcaatc cttcaatcct ctgtttgttg
    10921 ttgttctggc atatataatg ccgggtgtgt ggagcttcct caacaaacga aagatggaac
    10981 ctgcttctcc taccaaacaa gcgattggct tgttacttct ttctttaggt tatcttttca
    11041 tctgtttcgg agtgaaagat gctatccccg gagtgaaggt aagtatgatt tggctgacag
    11101 gactttattt tattcataca atgggtgaaa tagccttgtc acctatcgga ctttcaatgg
    11161 taaataagtt gagtccgcta cgtttcgcct ctttgatgat gggaatctgg tatctgtcta
    11221 ctgccacagc caataaattt gcaggcatgt tgagtggact ttatccggaa gccggaaaag
    11281 tgaaatcaat ctttggttat cagattgcta ccatgtacga tttctttatg gtattcgttg
    11341 tcatgtccgg tgttgcttca ttgattctgt tccttctctc gaagaaatta cagaagatga
    11401 tgcacggggt agaataaaaa atcgtatttt tgcaaggtta ttttttaaat taccggttat
    11461 ggataccatt cagataaaag acaaacagtt cactgtttct attaaggaac aggatattca
    11521 gaaagaagtg attcgcgtag cgaacgaaat caaccgcgac ttggcaggta agaatccgct
    11581 cttccttagt gtgttgaacg gttcatttat gtttactgcc gacttgttga agcacatcac
    11641 catcccttgc gagatttcgt ttgtgaaact ggcttcttat cagggagtga cttcctcggg
    11701 agtgattaag gaagtgatcg gactgaatga agacattgcc ggacgtacag tagttattgt
    11761 agaagatatt gtggataccg ggctaaccat gcaacgcctg ttggatacat tgggtacacg
    11821 caaccctgaa gcaatccata ttgcttctct gctagtgaag cctgaaaaac tcaaggtcaa
    11881 tctgaacatc gaatacgtag caatggaaat cccgaacgac tttatcgtag gttacggact
    11941 ggattatgat ggtttcggac gcaactatcc cgatatttat acagtagtag attaaacagt
    12001 taatattaaa taggtaccag tttaaatggt aaatagtaaa tcgttaaatt gtaaataaca
    12061 aaatgttgaa catcgtaatt ttcggtgctc cgggttcagg aaaaggaaca cagagcgaac
    12121 gtattgtaga aaagtatgga atcaatcaca tctcaacagg agatgtattg cgtgctgaaa
    12181 tcaagaatgg cacagaattg ggtaaaactg ctaaaggtta catcgaccaa ggtcaattga
    12241 ttcctgatga attaatgatt gatattctgg caagcgtatt cgacagcttc aaagatagca
    12301 aaggtgtaat tttcgacggt ttcccaagaa caattgcaca agctgaagca ttaaagaaaa
    12361 tgttggcaga aagaggacag gatgtttctg taatggttga cctggatgtt ccggaagaag
    12421 aactgatggt acgtctgatt aaacgtggta aggattccgg tcgtgctgat gataacgaag
    12481 agacaatcaa aaaacgtctg cacgtatatc attcacagac tgccccactg atcgactggt
    12541 acaagaacga aaagaaatac caacacatca acggcttggg tactatggaa ggtatctttg
    12601 ctgaaatctg cgaagcagta gataaattgt aatttagtaa tcttactaat tatcaataca
    12661 ctattataaa tgaataagtc agtcagtagc cggagtattc tacttaatta ctctaactac
    12721 tgactacttt aactacttaa aaagaatatg gctgaatcga attttgttga ttacgtaaag
    12781 atatactgtc gctcgggtaa gggcggaaga ggctctacgc acatgaggcg cgagaaatat
    12841 tgtcctaacg gaggtcccga tgggggcgat ggtggaagag gaggtcatat catcttgcgc
    12901 ggtaaccgta attactggac attgttgcac ttgaagtatg accgtcacgc aatggccggt
    12961 catggtgaat cggggagtaa aggacgtagt ttcggaaaag acggtgcgga taaagtaata
    13021 gaagtgccct gcggaacggt cgtttataat gccgagacag gggaatatct ttgtgacgta
    13081 acagaagacg gacaggaagt gatcttgctc aaaggcggtc gtggtggtca gggtaactgg
    13141 catttcaaga cggcaacccg tcaggctccg cgttttgcac agccgggaga accgatgcag
    13201 gaaatgaccg ttatcatgga gctgaaactg cttgccgatg ttggtctggt aggtttcccg
    13261 aatgcgggta agtcaacttt gctttcttct atttcggctg ccaaaccgaa aattgctgat
    13321 tatccgttta ctacgctcga acccaatttg ggtatcgttt cctatcacgg tggaaagtct
    13381 ttcgtgatgg cggacatacc gggtattatc gagggagcca gtcagggtaa aggcttggga
    13441 ctgcgtttcc tgcgtcatat cgagcgcaat tcattactgc tgtttatggt tccggcagac
    13501 agtgacgaca ttcgtaagga atacgaagtc ttgctgaacg aactgcgtac tttcaatcct
    13561 gaaatgttgg acaagcaacg tgtgttggct gtcaccaaga gcgatatgct cgatcaggaa
    13621 ttgatggacg aaatagaacc tacattgccg gaaggcattc cccacgtatt catatcttct
    13681 gtttccggtt tgggtatctc ggtgttgaaa gacattcttt gggaagaact gaataaggaa
    13741 agcaataaga tagaggacat cgttcaccgt ccgaaggacg taacccgtct gcaacaggag
    13801 ctcaaagaca tgggcgaaga tgaagacatc gtttatgaat atgatgacaa tgttgatgat
    13861 gatgacgatg atatcgacta tgaatacgag gaagaagatt gggaagaaaa atgatttcac
    13921 ttacaaaaaa taatgagttg aagggatata agtcactgga tgtatatccc gaggtagctc
    13981 atttcgtaac aacgcgtcac gaaggtataa gcaccggagc ttacggctct ttcaactgtt
    14041 cgccttatac caacgactca tgtatgaacg tcaatcgcaa tcagagctgg ttgtttcagt
    14101 gcatgaatca tcagataaag gagttgttta ttcctgaaca gagccatggt tgtgccagtc
    14161 tgattatcaa tgaatcattt tttaaagagt cattagaaat gagacggcta cttttgcgag
    14221 gaatggatgc cttgataact aatgtgccgg ggtattgcgt ttgcgtcacg acggcggatt
    14281 gtgtttctgt attgctgtac gacaaaaaac aacacgttgt ggctgccgtt catgccggat
    14341 ggaaaggaac tgtgaagcat attgtcagtc atgtgatgga tcacttgaat cagaaattcg
    14401 ggacgcaagg cgaagatgtg gtagcttgca tcgggccgag catttcgctc gaatcatttg
    14461 aagtaggtga tgaggtgtat gatgctttta aagaaagcgg tttcgatatg tctcttattt
    14521 ctatgaagaa gaaggagacg ggcaaatatc atattgattt gtgggaagcc aaccggattg
    14581 aattactgaa tgccggagtg cctgcagaac agatagaagt agctggcatc tgtacctata
    14641 ttcatcatga tgaattcttc tccgcacgta gactgggaat agattccggt cgtatcttgt
    14701 cgggaataat gattagaaag taataattgg tgtccgtaat tgcaggacgc tgatgattgg
    14761 tttatgataa gttatgtttg aaataaaagt atctaaagaa ataaaagacg catgcccggt
    14821 ttttgccgga gccgccgtgt atgctgcagt gaagaatact gcttacaacg aagggctttg
    14881 gcaggaaatc aacgctttta ccaggcaact gacttccact acacagatgg aagacatcaa
    14941 acatcaaccc gttatctttg ctacccgtga ggcttataaa cgttgtggca aagaccccgg
    15001 acgttatcgc ccgtcagccg aagctctacg ccgccgcctg atgcgtggaa tcccgctata
    15061 tcagattgat acactggtag acctgattaa cctcgtgtct cttcgtacgg gacattctat
    15121 tggtggtttc gatgcggata aaatacaagg tacgcacctt gaactcggta tcggcaaagc
    15181 tggagaaccg tttgaaggta tcggacgcgg ggtgttgaat atcgaa
//
