LOCUS       gnlProkkaGIAKINOE_18   10568 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GIAKINOE_18.
ACCESSION   gnlProkkaGIAKINOE_18
VERSION     gnlProkkaGIAKINOE_18
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 00:45:06
            Original ID  :: gnl|Prokka|GIAKINOE_18
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10568
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10568
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[1254:5568]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1255..5568
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..10568
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10568
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             43..1191
                     /locus_tag="ctg17_1"
                     /transl_table=11
                     /translation="MIEKQSYQEPFSEVDKRKDDEMEIDLMAIFYKIITVRGVLCKAAG
                     VGVIIAIVVALSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVLFGKSLLASLRKELKNKEIEQDK"
     CDS             1255..1974
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 56.8; E-value:
                     3.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg17_2"
                     /sec_met_domain="NTP_transf_3 (E-value: 4.8e-17, bitscore:
                     52.9, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CGIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLIAPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             1995..3296
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 209;
                     E-value: 1.4e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg17_3"
                     /sec_met_domain="CTP_transf_like (E-value: 2.4e-13,
                     bitscore: 40.7, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 1.1e-121, bitscore:
                     395.5, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 1.4e-63, bitscore:
                     204.8, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RIFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKTILENERALEVRELCMPIKEILELIPGTK"
     CDS             3313..4437
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 61.4;
                     E-value: 1.2e-18)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg17_4"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.4e-20, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3.3e-21, bitscore:
                     65.8, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIARGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             4447..5568
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 1.6e-33.
                     Score: 107.9. Matches aSDomain:
                     nrpspksdomains_ctg17_5_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 75.5; E-value:
                     6.4e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg17_5"
                     /sec_met_domain="Aminotran_5 (E-value: 1.6e-30, bitscore:
                     96.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLLVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKVSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        4537..5544
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg17_5_Aminotran_5.1"
                     /evalue="1.60E-33"
                     /label="ctg17_5_Aminotran_5.1"
                     /locus_tag="ctg17_5"
                     /protein_end="366"
                     /protein_start="30"
                     /score="107.9"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLLVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKVSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             5565..5708
                     /locus_tag="ctg17_6"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYGNIN
                     LR"
     CDS             5911..7395
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg17_7"
                     /sec_met_domain="Polysacc_synt (E-value: 1.8e-31, bitscore:
                     99.7, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENLKQKTVSGIMWSAIERFSLQGVQFIIQIILARLLLPSDYGMI
                     GMLAIFLQVAQVFIDSGFTNALIQKKDRTEEDFATVFYFNILVAVLFYGILFFSASLIA
                     DFYNMPTLVLVIRFIALSLIINALSAIHRTKLIISVNFKTQSKISLGAAFISGVIGIWM
                     AYVGCGVWALVWQTLLNSIILTILFYCLVHWKPLHTFSKSSFERLFNFGSKLLISSLIN
                     TVYRNLYTIVIGKKFSVVELGYYTRAEQFAIFPSNNLNALVSRVAYPILSSIQDDDKCL
                     TNAYRNYIRLSSYIIFPLMVGLLVLANPIISLLLTDKWSGVVILLQILCLDWMFDHLSQ
                     INLNLLWVKGRSDLSLRLEIIKKTIAIFILFVSIPFGLEVMCWGRVIYSLIATYLNTYY
                     TNSLIDLTLKLQVKDVFPSLILSFIMGGIVFICISFFETDIVKIVIGCITGMSFYILLS
                     FLFKLDSFFCILTLIIKTKNIDENIKKDFSSNSKDN"
     CDS             7349..8608
                     /locus_tag="ctg17_8"
                     /transl_table=11
                     /translation="MKILKKIFQVIVKIINHCVPVDSRSLYFIPHPNCRTDKYDIINYS
                     SDNVLVLLNYLLKKDSAEYYKIYVEIYDSSRISEYQEYIYGINPNIRCTFLCACVGRFF
                     FNKVSFKDMLYAFFCFCRASKCFTATFYYDFSFKKRSQQIICLGYYTPFKDDYHMGDHS
                     YDKFRNTTCNSFDYSIATSCLSARIISIDCGISYDKFKVLGFPRNDLLISKNNCNVIKR
                     EISKFAGYDVTKYIVYTPTFRDYETVTEGNLRSILGYVDCDLLKLSKILLKFNAALILK
                     LHPLQNKTVLKKDLPKGILVFEQTYKYGLYDLLSFSDGMITDYTSTYFDFLLVNKPVIF
                     NFYDIEEYRRVRGFSFEPIEFFCAGDIVYNYNELIDAVMGLLAGKDIHAEHRRHISLLM
                     NQFQDDNSTKRICDIFLNEI"
     CDS             8617..9366
                     /locus_tag="ctg17_9"
                     /transl_table=11
                     /translation="MNYAFVVQARLGSTRLPGKILKPFYGNQSILDLMVHKLSAISNIP
                     VIIATTNSVINEPIEKKALALGVKCFRGEENDVLKRFIDVAEYFDIQGIFRICSDNPFL
                     DVHAARQLVEIAMKSCNDYISFDIDGTPSIKTHFGFWGEFVTLDALKRVIGFTDDLLYR
                     EHVTNYIYSHPELFNIQWISGSPVVSKHHNIRLTIDTLEDFSVAQRIYRDLQEKRVEIS
                     IEVIVDYVRRHAEYIQLMKQQIKKNSK"
     CDS             9366..10406
                     /locus_tag="ctg17_10"
                     /transl_table=11
                     /translation="MKNTYIIGEIGQNHNGSVDLAKLIIELISRPVHEDVFGMDFMPMN
                     AVKMTKRDLSEELAVSQMNQIYDNPNSFGRTYGEHRAFLELDDQAHFEIYKYAKSLGLD
                     FIETLCAKGCLSLLKLFTPDRLKVASRDLTNLPLLEALAETHIPIILSTGMAGQRELDN
                     ALDVITRYHSNIAILHCVSQYPTHPNNLNLRTITYLKKHYNKFEIGFSDHTIGISAATA
                     AVAMGAEIIEKHVTIDRHMKGTDQLGSLGPDGVNRMIRDIRIAECWLGTEDLYIEKGVE
                     KSKIKLERSIATRKYIPAGSIIQESDIHLLSPGDGYKWIDKKNVIGHFAKQDISANEII
                     YPDFIE"
ORIGIN
        1 ttgcttctat tgctaatttg ataaagaaat aaatgaccta ttatgattga aaagcaatct
       61 tatcaagaac cgttttctga agtggataaa aggaaagatg atgaaatgga aatagacttg
      121 atggctattt tttataagat tattactgtt cgtggagtac tatgcaaagc tgctggagtg
      181 ggagtaataa ttgctatagt ggtggcattg agcattccca agcaatatac agtaaaggtt
      241 accctttctc ctgaaatggg taatgcgaag ggaagtaatg gtttagccgg acttgctgcc
      301 tcgtttttgg gagatggggc tctaataggg gaaagcacag atgccttgaa cgcttctctt
      361 tcagcagata ttgtttcttc aactcctttt ttattggaac ttttagaaat ggaagtctcc
      421 gtttctaaaa aggatgataa aatgactttg gggtcttatc tcgatgaaga gtcatctcct
      481 tggtgggatt atcttatagg ttttccgggc atagtaatag gaggagttaa atcattattc
      541 ggagaagata cggttcctgc cagtggaggg cggcaaggaa ctatcgaatt gacgaaagaa
      601 gtaaatgaga agattaattt tcttaaaaag aagattagtg catccattga taagaaaacc
      661 gccataacga gcattacggt caccttacaa aatccgcaga tcactgcggt tatagcagat
      721 tctgtcgttc ataaattaca ggaatatatt attgggtatc gaacttcaaa agtaaaagaa
      781 gactgtgcgt atttggaacg gttgtttaaa gaacgtcagc aggaatatta tgctgctcaa
      841 agaaaatatg cggattatgt agacgcccat gataatgtgg ttcttcaaag tgtacgtgct
      901 gagcaggagc gtttacagaa cgacatgagt ttggcttatc agatatatag tcaggttgct
      961 aatcagttgc aggtatccag agccaaagta caggaggaaa agccagtctt tgcagtagtt
     1021 gagcctgccg ttgtaccttt gaaaccttca ggtatgggac tcaaaattta tattttatta
     1081 tttgtgttcc tgtccgtatc tggtactctc gtgtgggtgc tttttggcaa aagtctgctg
     1141 gctagcttga gaaaagaact gaaaaataag gagatagaac aggataaatg atgctaaaac
     1201 gtcgtttaca acattcttat atcaattaaa ttcacttact atattattaa acgaatgata
     1261 cgtacagcta tgataatggc tgcgggcatg ggaacccgtt ttggccaata tacagaattg
     1321 atacctaaag ggttcgtcaa agtgggaggt attccaatga tagttcgttc tattgatact
     1381 ttgttatcat gtggcattga gcgaattgta atcggtacag gatataaaca agaagtttat
     1441 gaagaattga agacagacta tcctatgctt gaaacctgtt ttagtcctcg ttatgctgaa
     1501 acaaatagta tgtatacttt atataatacg cgggagattc tgggcaatga tgatttttta
     1561 ttgttagagt cagatttgat ttttgagaaa caagcaataa tgagcttatt ggagtgtcct
     1621 gcggcagatg caatgctaat agctccagtg acaaagtttc aagatcagta ttatgtggaa
     1681 catgatgata attttcgcct ttcttcatgt tctgtcaata agaataaact aaacgctaaa
     1741 ggcgaattgg tcggcatcca taaactatcc ggttcctttt acaaaataat gtgtgctgat
     1801 tatgcgagta ttgttgatga acaacccaat ttgggatatg agtatgaatt actacgaata
     1861 tcttgttctc aatctcctgt ttatgtgcat aaagtagaag ggctgaaatg gtatgaaatc
     1921 gatgacatat cagatttgga atatgcagag aaatatattg ttccgtattg ttaattaaaa
     1981 taatatatca aattatgagt aagacagttt atattgggat gactgcggat attatgcatc
     2041 caggacttat ccgcattatt aatgaggcta ctaaatacgg tgatgttata attggtcttc
     2101 ttacagataa agctattgcg gagcataaac gccttcctta tctgacctat gaacaacgaa
     2161 aagaggtagt tcagaatatt aaaggcgtat gtaaagttgt tcctcaagaa gaatggagct
     2221 atgttgagaa tctcaaacgc attaaacctg actatataat tcatggtgac gactggaaaa
     2281 ccgggccttt acgtgaagaa cgtgtgcgca tatttgaagt gatgaatgaa cagggaggaa
     2341 aggttatcga aattccatat actttgggaa ttaattcatc ttctttggat aaagatatta
     2401 aggctatagg tacaaccccc gatgtacgtt taaaatcact tcgtcgtttg ataaatgcca
     2461 aacccgtagt tcgtattttg gaagctcatg atggactatg tggcttgata attgaaaatc
     2521 aggaaatatt aaaaggggat aagagggaag tatttgacgg aatgtggtct agtagcctta
     2581 cggattcaac cagtaaaggt aaacctgata ttgaggcggt tgatttaact acccgattgc
     2641 aagatttgaa taatattctg gagtgtacta ctaaacctat tatttttgat ggagatacag
     2701 gtggtaaaat tgaacatttc gtatttacag tacgcacttt agaacgtcat ggaatctcag
     2761 ctataataat tgaagataaa gttggattaa aaaagaattc attgtttggt acggatgtta
     2821 ttcaaactca agatacaatc gaaggtttct gtaataagat caaagcagga aaggcatctc
     2881 agattactga tgattttatg attatcgctc gtattgagag ccttatagcg ggaaagccgg
     2941 taagtgatgc tttagagaga gcttttgcat atgtccaagc gggagcggac ggtattatga
     3001 tacatagcaa aaataagtcg ggtgaagata taaaagaatt ttgtttggcg tttcgaaaac
     3061 agtatgctca tgtacctatc gtggttgtgc ctactacata tgatcatatt tatgagtctg
     3121 aattgtgtga ttggggtgtg aatataatta tttatgctaa tcatatgctt cgtgccgctt
     3181 atcctgctat gatgaatgtc gcaaagacaa tattagagaa tgaacgtgct ttagaggtgc
     3241 gcgaactgtg tatgcccata aaggaaatat tggaactgat tccgggtact aaataaaaag
     3301 aggaatatca ttatgttaag cgtagaaaaa gtttatgaaa cgtttctgag tcatgacgtt
     3361 gattttttta caggagttcc agactcatta ctaaaaaata tttgtgccta tatcacagac
     3421 catacttcac gtgagaaaca tatcatagct gctaatgaag gtgcggctgt aggaattgct
     3481 tcaggttatt atatggcatc aggtaaggtt cctgtggttt atatgcaaaa ttccggcttg
     3541 ggtaatactg ttaatcctct gctgtctctt gcagatgaac aagtatacag ttttccaatg
     3601 cttttgatga ttggctggcg tggtgaaccg ggaacaaaag atgaacctca gcataaaaaa
     3661 cagggtgagg taactttaga tttgttgaaa gcaatgcgga ttccttatat aattcttgat
     3721 tcaaatgaga atgatgcatt tattcagctc catgatatca tacaatcagc aaaaactaag
     3781 aatattcctc atgcaataat tattcggaaa gatgtttttg gcaaatataa acttcaaaaa
     3841 gaattcggat gtaattatcc tttatctcgt gaggatgctt tgcaaatagt tgtggattat
     3901 ctgcctgaaa attcagtggt cgtttctact actggcaagc tttctcgtga gttatttgaa
     3961 tatcgagaaa tgaaagagca aggtcatgaa catgattttc tcacggtagg ctctatggga
     4021 catagttcat caatctcttt gggtattgct atagcaaagc aagatagacc tgtttattgc
     4081 ttggatggtg atggagcatt tattatgcat ttaggggcaa ttagtaacat tggcgattta
     4141 tctcctaaaa actattatca tattttgttt aacaatggtg ctcacgagtc tgtaggagga
     4201 cagcctactt taggatttag tttagatatt ccggctattg cccgggggag cggatataag
     4261 catacttata ctgtttgtac aaaagttgaa attgaagaag caatgaagca gcttccaaag
     4321 ttatgtggtc ctgttttgtt ggaaataaag gttaagatag attctcggga gaatttggga
     4381 cgtcccacga ctactcctat agagaataag gagcatttta tggatttttt aaaataaata
     4441 tattcgatga aaatagaaag aaaaatatta ttaaatcctg ggcctgccac tactactgac
     4501 agtgtaaaaa tggcacaagt tgttccggat atttgtcctc gcgagaaaga attcgcaggt
     4561 atgatgaaac aacttcggga cgatttggtc agagttgctc atgggaattt ggaaaaacat
     4621 acagctgtat tattttgtgg ctcaggaact atcaatattg atatatgtct aaattctctt
     4681 cttcctgaag acaaaagggt gcttatagtg aataatgggg catatagtac ccgtgctgta
     4741 gaagtgtgtc aatattatgg tttgcctcat attaatttgg aattttctgt ttatgaacgt
     4801 cctgatttat tggtagtgga aaatgtgtta caagaaaatc ctgatatagc tatggtttat
     4861 actactcatc acgagacggg tacaggaatt ctgaacccta ttcgcgagat gggcgctata
     4921 gctcataaat atcaggctaa atttgtcgtc gatactactt cttctttggg catgattcct
     4981 tttgatatag agaaagataa tgtagatttt tgtatggcat ctgctcaaaa aggacttcaa
     5041 gcgatgacag gtctttcttt tattataggc aatgaggaac agattaaggt ttcaaaaaaa
     5101 tatcccaagc gttcttacta ttgtaatctt tatttgcagt atgagaattt tgagagaaca
     5161 ggtgaaatgc attttactcc accggtacaa actatttacg ccactcgtca ggcattaaat
     5221 gaatattttg aagtgggcga agaagctaag tttgcccgtc acaaaagagt ttttgaggct
     5281 attcattcag gtataaatga aattggtctt aaaagtgtaa taaagcgtga atggcagtca
     5341 ggactggttg tctcagttca atacccagaa gatcccaact gggattttga gaaaatacat
     5401 gattattgtt atgagcgtgg atttacgatt tatccaggta agatatcaac tgaggatact
     5461 tttagaatct gtgctttagg agagatagaa gtagatgata ttgagaactt ctttaaagta
     5521 ctaaaagctg cattaaatca ttataacgtc acattaccga tgtcatgatt gcagaaatat
     5581 tattgaagat tcgtcatttt tatttttccc ttcgtggtat acacttccat ccggaaagtg
     5641 ttatttctgg agtgcctatt cgtagctttc gcttagtagg caaatatggc aatattaatt
     5701 tgaggtgatg cattaggagt tctttattct tataaaaagg catcggtagt tataggagat
     5761 aatgtttgtg tagggtaatt tgcttttagt gggagagacc atattagaat tgcggtaagg
     5821 ggcgaagaag ataataacca attagtgaga atattggaaa aatataattg atatcggtaa
     5881 atgtagttgt ttttatactg tatttaagta atggaaaatc taaagcagaa aactgtatca
     5941 ggaataatgt ggagcgctat agaacgtttc tctttacaag gagtacagtt tataattcaa
     6001 ataatattag ctcgtttgtt actaccatcg gattatggta tgatcgggat gttagctatt
     6061 tttcttcaag tcgctcaagt atttatagat agcggtttta caaatgcttt aatccagaaa
     6121 aaagatagaa ctgaagagga ttttgccact gtcttttatt ttaatattct tgtcgcagta
     6181 ttattctatg gtatattgtt tttttcggct tctttgattg cagactttta taatatgccg
     6241 actttagttc ttgtaattcg ttttatagca ttgtcgttga taataaatgc tttatcggct
     6301 attcacagaa cgaaattaat tatttctgta aactttaaaa ctcaatctaa aatttcatta
     6361 ggtgcagctt ttatatcagg cgtgattgga atatggatgg cttatgtcgg ttgcggggtt
     6421 tgggctttag tttggcaaac tctcttaaat agtataattt tgacaatttt gttttactgt
     6481 ttagttcatt ggaaaccttt acatactttc tccaaaagtt cttttgaaag attattcaat
     6541 ttcggatcta aattattgat ctcaagtctt atcaatacag tatatcgtaa tctgtatacc
     6601 attgtaatag gaaaaaagtt ttctgttgta gagcttggtt actatacaag agcagaacaa
     6661 tttgctattt ttccttccaa taatttaaat gctttagttt ctagagtagc gtatcctatt
     6721 ttaagttcca ttcaagatga tgataaatgt ttaacaaacg catatcgaaa ttatatcaga
     6781 ttatcctcat atataatttt tcctttaatg gtaggtttac ttgttttggc taatcctatt
     6841 attagtctat tgttaacaga taaatggtct ggggttgtta ttcttttaca gatattatgt
     6901 ttggattgga tgtttgatca tttgagccaa attaatttga atttattatg ggttaaagga
     6961 agatctgatc tgtcgttacg tcttgaaata ataaaaaaga cgattgctat attcattctt
     7021 tttgtgtcaa ttccatttgg gcttgaggtg atgtgttggg gtagagttat ttactctctg
     7081 atagcgacat atttgaatac atattatact aattctctta ttgatttgac cttaaagttg
     7141 caagttaaag atgtatttcc aagtttaata ctctctttca taatgggggg gatcgttttt
     7201 atatgtattt ctttctttga aactgatata gtaaaaattg tgattggatg tattactggg
     7261 atgtccttct atattttact ttcttttctt tttaagctag attctttttt ttgtatttta
     7321 acattgatca ttaaaactaa aaacatagat gaaaatatta aaaaagattt ttcaagtaat
     7381 agtaaagata attaaccatt gtgtgccagt tgatagtaga tcattgtatt ttattcctca
     7441 tcctaattgt agaacagata aatatgatat tataaattat tcgtcagata atgttctcgt
     7501 tctgttaaat tatttgctaa aaaaagatag tgctgaatat tataaaatat atgttgaaat
     7561 ttatgattct tctcgtattt cagaatatca agaatatatt tatggcataa atcctaatat
     7621 taggtgtact tttttatgtg catgtgttgg acgttttttc tttaataaag tatcttttaa
     7681 ggatatgttg tatgcctttt tttgtttttg tagagcaagt aaatgtttta cagctacttt
     7741 ttattatgat ttttcattta aaaaacgctc tcaacagatt atttgtttgg ggtattatac
     7801 tccattcaaa gatgattatc atatgggaga tcattcttat gataaatttc gtaatacaac
     7861 atgtaactca tttgattact ctattgctac ttcttgttta agtgctagaa taatttcaat
     7921 agattgtgga atctcatatg ataaattcaa agtcttagga tttcccagaa atgatttgtt
     7981 gatatcgaaa aataattgca atgttattaa aagagaaatt tcgaaatttg cgggatatga
     8041 tgtaactaaa tatatagttt atactccaac ttttcgtgat tatgagactg ttactgaagg
     8101 taatttgcgt tcaatactcg gatatgttga ttgtgatttg ttgaagttat cgaaaatact
     8161 attgaagttt aatgcggctt taattcttaa attacatcct ttgcagaata aaacagtctt
     8221 aaaaaaagat ttacccaaag gtatacttgt ttttgaacaa acatataaat atggattgta
     8281 tgatcttttg tcattttcag atggaatgat tactgattat acttctacct attttgattt
     8341 tttattggta aataagccag tcatatttaa tttctacgat attgaagaat atcgtagagt
     8401 aagaggtttc tcatttgagc caatagaatt tttttgtgca ggtgatattg tttacaatta
     8461 taatgaattg atagatgctg tgatgggact tctggctggg aaagatattc atgctgaaca
     8521 tcgacgtcat atttctttat tgatgaatca atttcaagat gataattcaa caaagagaat
     8581 atgtgacata tttttaaatg aaatataata aataaaatga attatgcatt tgtggtgcag
     8641 gcacgtttag gttctacacg tttgcctgga aaaatattga aacctttcta tggtaatcaa
     8701 tcgattcttg acttaatggt tcataagctt tctgctatat cgaatattcc agtaattatt
     8761 gctacaacaa attctgttat caatgaacct attgaaaaga aggcacttgc attaggggta
     8821 aagtgcttca gaggtgagga gaatgatgtt ttaaaacgat tcattgatgt tgctgaatat
     8881 tttgatatac agggtatatt ccgaatatgt tctgataatc catttttaga tgtacatgcg
     8941 gcaaggcaat tggtcgaaat agcaatgaaa tcttgtaacg attatataag ttttgatatt
     9001 gatggtactc catcaattaa aactcatttc ggtttttggg gagaatttgt aacgcttgat
     9061 gcgctgaagc gagttatagg atttactgat gatttattgt atcgtgaaca tgttactaat
     9121 tatatatata gtcatcctga actttttaat attcaatgga tttcaggatc tccagtcgtg
     9181 tcaaaacatc ataatattcg actcacgatt gatacgttag aagatttttc tgtagcacag
     9241 agaatatata gggatttaca agaaaaaaga gtggaaatat cgatagaagt gattgtagac
     9301 tatgttcgaa gacatgcaga atacattcaa ctgatgaaac aacaaataaa aaaaaattct
     9361 aaataatgaa gaatacttat attattggtg aaatagggca gaatcataat ggttctgttg
     9421 acttggctaa gttgattatt gaattaatct cacgacctgt acatgaggat gtttttggta
     9481 tggatttcat gccaatgaat gctgttaaaa tgactaaaag agatttatca gaagaattgg
     9541 ctgtttctca aatgaatcaa atatatgaca atcctaattc ttttgggcgt acttatggtg
     9601 aacatcgtgc ttttcttgag cttgatgatc aagcgcattt tgagatttat aaatatgcta
     9661 agtcattagg attagatttt atcgagacgt tatgtgccaa aggatgtctg tctttgctta
     9721 aactgttcac accggatagg ctaaaagttg ctagtcgtga tttgactaac ttaccattgc
     9781 ttgaagcatt agcagaaact catattccta ttatattatc gacaggaatg gctggtcaaa
     9841 gagaacttga caatgcatta gatgtgataa cgagatatca tagtaatata gctattctac
     9901 attgtgtatc tcagtatcca actcatccaa ataatttgaa tctacgtaca ataacatatt
     9961 tgaagaagca ttacaataag tttgagatag gtttttctga tcatacaata ggtatttctg
    10021 ctgctacagc tgctgtagcg atgggagcgg aaattataga aaagcatgta acaattgatc
    10081 ggcatatgaa aggaacagac cagcttggct ctttaggtcc agatggggtt aatcgtatga
    10141 ttcgagatat tcgcatagca gagtgttggc ttggtactga agatctttat atagaaaaag
    10201 gggtggagaa gtctaagata aaacttgaac gttctattgc cactcgaaaa tatattccag
    10261 caggtagtat tattcaagag tcggacattc atttactgag tcctggtgat ggttataaat
    10321 ggatagataa aaaaaatgta attggtcatt ttgctaaaca agatatatca gcgaatgaaa
    10381 taatatatcc tgattttatt gaatagatat attcctactg caacttgtat tacggtatag
    10441 agtactgcct gctataagct aagtagtgat taataaataa gggtaaaata ctaaaaaaat
    10501 gaaagagata aagcttatac ttacagatat tgatggcgtt tggactgatg gcggaatgtt
    10561 ttatgatc
//
