LOCUS       gnlProkkaIEOCCBKM_23   13903 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|IEOCCBKM_23.
ACCESSION   gnlProkkaIEOCCBKM_23
VERSION     gnlProkkaIEOCCBKM_23
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 03:52:33
            Original ID  :: gnl|Prokka|IEOCCBKM_23
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13903
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13903
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[3197:3903]"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3198..3903
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     cand_cluster    1..13903
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13903
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="1"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     CDS             complement(397..834)
                     /locus_tag="ctg23_1"
                     /transl_table=11
                     /translation="MIRLYTQSSCHSSRVARQWLEAHGIEFKEKNFSVDSPTVQDLKRI
                     LSLTEHGVDDIISARSKDYPEIAPKLPEMPLNEALKLLCDHPKLLRRPIIISDSKIQVG
                     FNEDDIRQFIPRPVRRLKFNALLSRLDGNTGDHIINKRMVE"
     CDS             complement(1190..1933)
                     /locus_tag="ctg23_2"
                     /transl_table=11
                     /translation="MISVYICEDDPKQLQQIRQIITKVIVDQQLDMSICLACQDPHELL
                     DKVNAQQPQKAIYVLDIALNSDINGIQLASQIRDMGRRSKIIFITTHTELSLMVFQYQV
                     EALDFILKDFPDSLYERFSKVLHVAQDRFQTDENDQDDYVQIKIGETVRSINVKSIIFF
                     ESSTSPHKIVVHLDDGELEYYGLLKDVPDLSPNFYRCHKSYVVNLKRIKSLDKHLRRLT
                     MTNGEKVLCSAQANRYLAKWLAKKS"
     CDS             complement(1926..3188)
                     /locus_tag="ctg23_3"
                     /transl_table=11
                     /translation="MLMIVFQELSIYLIIKSLLRNIFFVRLFDVIFLSVCMLMSYIFLA
                     KLGISFSFLMLMMFIFFTWWYVRVLSGALCITFQVFIWSIMVDHICDILTRLMKVPNGY
                     VVVFVILSVVSLIFLNIVMDRTNFSPTFSNQSLNRITALLLMIIYLYIMLSEGLENQFQ
                     VILSNLIILSVVMGLVLVIYNEYLKNVRAKYEIQKQRIQIQNDTRYMNEIEAHYNELRR
                     FRHDYQNMLISIDEYLKTDDLEGLQEYYQKNLAPVSNRVLKEKYNLEDLSRVKVKSIKS
                     ILFSKLSYAQSQEIEVHFDLKEPLIDITVNELDLDIALGIMLDNAIEASVGHADGEIMS
                     AIFIEKNSTVFLIQNNVFEQLPPLWKLKEAGYSTKGKNRGIGLNSLSKIVNRNENMILE
                     TRVLGAVFLQRLTVKRVSQND"
     CDS             complement(3198..3326)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: TIGR04223"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg23_4"
                     /sec_met_domain="TIGR04223 (E-value: 1.5e-07, bitscore:
                     25.3, seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEKMYKVLSHLFQYVGTKQLVMCCHGILFETKIPDELKSKD"
     CDS             complement(3307..3903)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg23_5"
                     /sec_met_domain="AgrB (E-value: 3.4e-34, bitscore: 111.6,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKPEQKLLLYKLSDRLFAAIQKNLQLERRQALLVKLGIDTVLNV
                     IPKLIITIILALLLHELVPVLVFMGSFLVLRGFAYGRHLKSDLLCTILTIFVFVGVPYV
                     IGTGISEVYRLLLSLIFVIIISIFAPADTVKNPITSKSLRKKLKRRAIGLSLILSLLQI
                     VSNNYFGTIILIAMALAALLLMPYERRENYERKNV"
     CDS             complement(4271..6385)
                     /gene_functions="other (smcogs) SMCOG1223:ATPase (Score:
                     961.7; E-value: 5.4e-291)"
                     /gene_kind="other"
                     /locus_tag="ctg23_6"
                     /transl_table=11
                     /translation="MANFYGNDPFFNNDMDDVFNQLFRRMDNQNSERARYLVNGQSLTP
                     DEFAQYRATGKLPQNNKTIEVSKDGKQAVKKGGILEKLGTNLTEQARDGLLDPVIGREN
                     EIQETAEILSRRTKNNPILVGDAGVGKTAVVEGLAQAIVAGKVPETIQDKEIYSIDLSS
                     LEAGTQYRGSFEENIKQLVKEVKAAGNIILFFDEIHQIIGTGATGGEDGGKGLADIIKP
                     ALSRGELTVIGATTQDEYRNTILKNAALARRFNDVVINEPTAADTLRILQGVKKLYEKH
                     HHVVLPDDVLKAAVDYSIQYIPQRTLPDKAIDLIDMTAAHLAAKNSQTDVETLDQRVKK
                     LEAAKEAAVKSEDFTKAADIKKSIEETKQKIKKTDQKEKITATIDDVAQSVERLTGIPV
                     ADMGANDIEHLKNLDKRLKSKVIGQDEAVEMVAKAIRRNRAGFSEGDQPIGSFLFVGPT
                     GVGKTELAKQLALDMFGNKNAIIRLDMSEYADRTAVSKLIGTSAGYVGYEDNANTLTER
                     VRRNPYSIVLLDEIEKADPQVLTLLLQVMDDGRLTDGQGNVINFKNTIIIATSNAGFGN
                     EALSGDKQRDQSLMDKLAPFFRPEFLNRFNGIVEFSHLTKQDLSQIVDLMLADVQKTLA
                     KKSIKLEVTKAAKDWLMEQGYDEAMGARPLRRVIEQQIRDKVTDFYLDHLDVKNLKADL
                     VDAEIVISAA"
     CDS             complement(6776..7009)
                     /locus_tag="ctg23_7"
                     /transl_table=11
                     /translation="MSVENNYCKLQQAHDQKCRVSLRFYKTNGQMAETVGYVTTIVPKA
                     IAFMAITGHRHLIQLNRIITVSLQSQDRRYVM"
     CDS             complement(7646..8746)
                     /locus_tag="ctg23_8"
                     /transl_table=11
                     /translation="MTVINGYEQSDREQKLTILNLPSLEAAAKKIIPSGGFGYISGGSE
                     DEWTLKQNTMAFNHVQIVPRALTDMEQPSTQTQAFGIDLKTPIMMAPAAAQGLAHARGE
                     AATAEGMAQVGALMAQSTYSSTSIADTAAAGKGAPQFFQLYMSKDWNFNQSLVDEAVKA
                     GAKAIILTVDATVDGYREADIINNFQFPIPMANLTKFSEGDGKGKGIIEIYAAAAQKIS
                     PADVRRITEYTNLPVIVKGIQSPEDALLAIGAGAQGIYVSNHGGRQLNGGPASFDVLHE
                     IAQAVNGRVPTIFDSGVRRGSHVFKALANGADLVALARPIIYGLALGGAQGVASVVSHL
                     NDELLIDMQLAGTKTIEDVKRAKLLR"
     CDS             complement(8773..10521)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 469.1;
                     E-value: 3.4e-142)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg23_9"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.5e-40, bitscore:
                     132.4, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.3e-31, bitscore:
                     102.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKIKAGQALAQVLVDWNIDHIYGITADSINNTVDGFYQEKDHLK
                     YIQVRHEEVGALAAAADAKLTGTIGVSFGSAGPGAVHLLNGLYDAKMDHVPVLALVGQS
                     ATSIMNTNFFQEMNQDPIFADVAEFHKQVTTAEQIPYVVDEAIRSAYATRSVSVVIIPD
                     DLSGQDIEFDGFKTASLSGSQQVLMPKLDDVQQTIAALKAAQHPVLWIGKGAYNARQEV
                     IAVSEKFSLPVLSTAPATGIMPTDHPNFMGSRGRLGTKPAFEVSQAADLVLFVGTNFPF
                     ARYLSQGIKFIQVNNNLADLGKQHDADITVLADAKEFFQALLQSEVTIKPTKFLKAAQR
                     DKQNWNRWLKTIATDDQGGLTAEGVLEAIKDNATDDAVFGLDVGNNTEWAIRQLPLNKQ
                     QTFTMSAWYGTMGFGLPAGLAAQLNYPKKQVWSISGDGGYAMVMPDLLTEVKYHLPVIN
                     VVLENKVLGFIQHEKLLANQAPYGIDLIGADWAKMADNMGAIGFKVTNLKELKATFQKV
                     TQLQQNGNQLPIVIDAKIKNVDPIDTSFVPVDPENFDADTIAKYRERYGIAEADQPALS
                     QLLNEL"
     CDS             complement(10609..11034)
                     /locus_tag="ctg23_10"
                     /transl_table=11
                     /translation="MANTQLSDATHIMAYIALHTDDQLKSEHIASSLNTDPTMVRRMMS
                     KLRKAGLLTSVRGVARPTLACSPNDITLKDIYVAVVAKRNFLNVDHNTSETCPVGSVIP
                     RVMEKYYCDIQNSAEARMSRVTLQDIIDDISAVQQQA"
     CDS             complement(11207..13018)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 494.2;
                     E-value: 8.6e-150)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg23_11"
                     /sec_met_domain="TPP_enzyme_N (E-value: 9.7e-44, bitscore:
                     142.8, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.1e-37, bitscore:
                     123.1, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVMKQTKQTNILAGAAVIKVLEAWGVDHLYGIPGGSINSIMDALS
                     AERDRIHYIQVRHEEVGAMAAAADAKLTGKIGVCFGSAGPGGTHLMNGLYDAREDHVPV
                     LALIGQFGTTGMNMDTFQEMNENPIYADVADYNVTAVNAATLPHVIDEAIRRAYAHQGV
                     AVVQIPVDLPWQQIPAEDWYASANSYQTPLLPEPDVQAVTRLTQTLLAAERPLIYYGIG
                     ARKAGKELEQLSKTLKIPLMSTYPAKGIVADRYPAYLGSANRVAQKPANEALAQADVVL
                     FVGNNYPFAEVSKAFKNTRYFLQIDIDPAKLGKRHKTDIAVLADAQKTLAAILAQVSER
                     ESTPWWQANLANVKNWRAYLASLEDKQEGPLQAYQVLRAVNKIAEPDAIYSIDVGDINL
                     NANRHLKLTPSNRHITSNLFATMGVGIPGAIAAKLNYPERQVFNLAGDGGASMTMQDLA
                     TQVQYHLPVINVVFTNCQYGFIKDEQEDTNQNDFIGVEFNDIDFSKIADGVHMQAFRVN
                     KIEQLPDVFEQAKAIAQHEPVLIDAVITGDRPLPAEKLRLDSATSSAADIEAFKQRYEA
                     QDLQPLSTYLKQFGLDDLQHQIGQGGF"
     CDS             complement(13389..13766)
                     /locus_tag="ctg23_12"
                     /transl_table=11
                     /translation="MMTKERIIFSTKVLEIGAESADFKSIGMAVLFGDEAPDALRPSCF
                     IIEVVPISEQITAGMKLEVDNQVYQITAVGGEVQTNLGRLGHTAISFTGAKEAKLPGTL
                     YVEQGDYPDFKVGSVVRIIAE"
ORIGIN
        1 agcgaccgct taaaatactc gactggcaaa caccgtatca ggttatgctg acaaatttgt
       61 ccaaaaattc ggattaaatt tgcaatctac ctaatactat caaagatgcg ttaggccaag
      121 ttactttgcc tggtgtcaaa aaactcgaaa tcaagcaatt ttatgaggcc gacaaaaact
      181 acggtacacg cgtggctaat gctctgggaa tgaatattgc tgatattatc agtgattaat
      241 attttgaccg gatgttatcc agcgcgatat tatttttgtt ataaagaatg atgatgccgt
      301 ctcatggtta ttaactaaag agcgacaggt tagactcata tcgtgtaagt ctagcttgtc
      361 gctctttaat taacaaaaaa tcttagatat agcttactac tcgaccatcc ttttattaat
      421 aatgtgatcc cctgtattac catctagacg actcaacaat gcattgaact ttagtcgccg
      481 aactggtcgt ggaataaatt ggcgaatatc atcttcatta aagccaactt gaattttact
      541 atcactaatg atgataggcc gacgtaacaa cttcggatga tcacacaaca atttaagtgc
      601 ctcattcaat ggcatttcgg gtaacttagg cgcaatttca ggatagtctt tagatcgagc
      661 tgagataata tcgtctacac catgttcggt taaactcaaa atacgtttta gatcttgcac
      721 cgtgggcgaa tcaacactaa aatttttctc cttgaactca atcccatgtg cttccaacca
      781 ttgccgtgca actctagaag aatgacagct tgattgtgta tataacctaa tcattcctaa
      841 tctgcccctc tctcgttaaa attcatcaca gcgtattgat cgacattaac ttctgcctgt
      901 cacaacatcc tttaaactaa acgcattcgt tactgtcatg accaatccaa taccccgtga
      961 acacatcttt attataggct ctgaacaagg gacataccga ccgttttaag acgaataatc
     1021 tgaggataat cgttttaagt acacttttaa acggtttagg aaagaacgaa cccagtacac
     1081 gtaatgctaa caaatatcac tgcaatttct aatcgaataa cgctgaattt tcatcgcgta
     1141 gcacataaaa agtcgcctac taatttagca ggcgacttcc ttggaactat tatgactttt
     1201 tagcaagcca tttagctaga taacgattag cttgtgcaga acaaagcact ttttcaccat
     1261 ttgtcatggt taatcgtcgc aagtgcttgt ccaatgactt aatgcgtttc aagttaacaa
     1321 catatgactt atgacaccta tagaaattag gactcaaatc aggaacgtcc tttaacagtc
     1381 catagtattc taattcacca tcatccaaat ggactacgat tttatgggga ctggttgaac
     1441 tttcaaaaaa tataatgctt ttaacattaa ttgatctgac cgtctcacca atttttattt
     1501 gaacatagtc gtcttggtca ttttcatcgg tttgaaaacg atcttgcgcc acgtgtaaaa
     1561 ccttgctaaa tcgctcatac aaggaatctg gaaaatcctt aagaataaaa tctaatgcct
     1621 caacttgata ttgaaacacc atcaaagata actccgtgtg tgtcgtgata aaaataatct
     1681 tgctgcgacg gcccatgtca cgaatctggc tagctagttg aataccatta atatctgaat
     1741 taagggcaat atctaacaca tagattgcct tttgaggctg ctgtgcatta accttgtcta
     1801 acaattcgtg gggatcttgg catgctaaac agatactcat gtctagctgt tgatcgacga
     1861 ttaccttagt aatgatttgc cgtatttgtt gtaattgttt cggatcatct tcgcaaatgt
     1921 agacactaat cattctgaga tactcgcttc accgtcaagc gttgtaagaa taccgctcct
     1981 aagactctgg tttcgagtat catgttctca ttgcgattaa caatcttact taaactattc
     2041 aatccaatcc cccgattctt gcccttagtg gaataacctg cctctttcag cttccataag
     2101 ggtggtaact gttcaaaaac attgttttga atcaagaaca ccgtactatt tttttcgata
     2161 aaaatggcac tcataatctc tccatcagca tgtcctaccg atgcttcgat tgcattatcc
     2221 aacataatcc ctaatgcaat gtctaaatcc aattcattaa cagtaatgtc aattaatggt
     2281 tcctttaaat caaaatgaac ttcaatctct tgcgattgtg catagctcaa cttactaaat
     2341 aggatactct taatcgactt cactttgacc cgactcaaat cttcaagatt atatttttct
     2401 tttaacaccc gatttgaaac cggtgcaaga ttcttttgat aatattcttg taaaccttct
     2461 aaatcatcag ttttcaaata ttcatctatc gaaatcaaca tattctgata gtcatgtctg
     2521 aaacgtcgca actcattata gtgagcttcg atttcattca tatagcgagt atcattttgt
     2581 atttgtattc tttgcttttg gatttcatat ttggctctta cattttttaa atattcgtta
     2641 taaatcacca atactaaccc cattacaact gacaatataa ttaaattact taatataacc
     2701 tggaactgat tttccagacc ttcactcaac ataatataca agtatattat cattaataat
     2761 agtgcggtta tgcgatttaa gctctgatta ctaaacgtgg gactgaaatt cgtgcgatcc
     2821 attacaatat taagaaaaat taagcttacg acactcaata tgacaaacac taccacatac
     2881 ccattaggaa ctttcattaa acgagttaat atatcacaaa tatggtcaac cataatcgac
     2941 catatgaaca cttgaaatgt tatacatagt gcaccgctta gaactcgtac ataccaccaa
     3001 gtgaaaaata taaacatcat taacattaaa aaagaaaaac taattcctaa ctttgctaaa
     3061 aaaatataac tcatcagcat acagacggat aagaatataa catcaaaaag tctcacaaaa
     3121 aatatatttc tcaacaaaga tttaattatc aaatagatag ataattcttg gaagacaatc
     3181 attaacatat atctacacta atccttgctt tttaattcat caggaatttt agtttcgaat
     3241 aatatcccat ggcagcacat aaccaactgt ttagtaccta cgtattgaaa aagatggcta
     3301 agtactttat acattttttc tttcataatt ttccctcctt tcatagggca ttagtaataa
     3361 agcggctaat gccatcgcaa ttaaaatgat tgtgccaaaa taattattac taactatttg
     3421 taacaaactc aaaattaatg acaatccaat tgcccgtcgc tttaattttt ttctcaatga
     3481 cttcgatgta ataggattct ttaccgtatc agctggagca aaaatactta tgattattac
     3541 aaatattaaa cttaataaca atctgtatac ttcagaaata ccagttccaa tcacatacgg
     3601 cacacccaca aacacaaaga tagttaatat cgtacataac aaatccgatt tcaagtgacg
     3661 tccataggca aagccacgca aaactaaaaa actacccata aaaactaaca ctgggaccaa
     3721 ctcgtgtagc agcaacgcta agataatagt aattatcagc ttaggaataa catttaatac
     3781 agtatcaatg cctagtttaa ctagtaatgc ctgccgtctt tctagttgaa gattcttttg
     3841 aatcgcagcg aataaccgat cgcttaattt ataaagcaat agtttttgtt ctggcttttc
     3901 catatcccac tcctataatg ctcaaataca tacctgtatc aacagtttaa aacagtatta
     3961 attaattgaa aagaatacat aaatatatta attattcaat attgttttaa gactagaaat
     4021 aaacatttaa agatacatca gtttaattat tcatacgaaa ctaaagtttc atgtaaaaag
     4081 atcgttaata taaatcagtt tcatcgatac tcccccttaa tttttcctta gattacaagt
     4141 caaactagac ttaatttcac taattcacat tactcaatag attaatatca aatggtgaaa
     4201 atcaacgaaa agaggagatc tatcaagcaa tctcctctta cataaagtta tttatgaaca
     4261 ctgatttaag ctaagctgcc gatatcacaa tctcagcatc cactaaatca gccttcaagt
     4321 ttttgacatc taagtggtca aggtagaaat ccgttacctt gtcacgaatt tgttgttcaa
     4381 ttactcgccg taatggccgc gcacccatcg cttcatcata gccttgttcc atcagccaat
     4441 ctttggccgc tttagttacc tcaagtttga tggatttttt ggctaacgtt ttttgtacat
     4501 ccgccaacat caaatcgaca atttgactta agtcttgctt agtcagatgt gaaaattcca
     4561 cgattccatt aaaacggttc agaaattctg ggcggaaaaa tggtgctaac ttatccatta
     4621 atgactgatc tcgttgcttg tcaccactta atgcttcatt accaaagcca gcattagaag
     4681 tagcgataat aatcgtattt ttgaaattaa tgacattgcc ttgtccatcc gttaagcgcc
     4741 catcatccat cacttgtaac agtaacgtta atacttgtgg atcagccttt tcaatttcat
     4801 ctaataatac aatggaatat ggattacgcc gaacccgttc ggttagagta ttagcattat
     4861 cttcatagcc tacgtatcca gccgaggtac caattaattt cgacacagct gtacgatcag
     4921 catattcact catatctagc cgaataatcg catttttatt tccaaacata tctaaggcta
     4981 attgcttagc taattcagtc tttcctacgc cagttgggcc cacaaacaga aaacttccaa
     5041 ttggctgatc accctctgaa aagcccgcac ggttacgccg aattgccttc gctaccattt
     5101 caaccgcttc atcttgaccg attaccttac ttttcagacg cttatcaaga tttttcaagt
     5161 gctcaatatc attagcgccc atatcagcaa ctggtatacc agttaaacgt tcaaccgatt
     5221 gtgccacatc atcaatcgtg gcagtgattt tttctttttg atccgttttt ttaatttttt
     5281 gcttggtttc ctcgatcgac ttcttgatat cagcggcttt tgtaaagtcc tccgatttaa
     5341 cggcggcctc cttagctgcc tctaattttt taacgcgttg atccaatgtc tcaacatcag
     5401 tttgcgaatt tttagccgct aaatgagccg cagtcatgtc gatcaaatcg atagctttat
     5461 ctggcaaagt gcgttgtggt atatattgga ttgaataatc cacagccgcc ttcaaaacat
     5521 catctggtaa tacaacatga tgatgctttt cgtacagctt tttaacacct tgtaatatac
     5581 gtaaagtgtc agcggccgtc ggttcattaa tcacaacatc attgaatcgc cgtgccaaag
     5641 ccgcattttt caaaatagta ttgcgatatt catcttgagt cgtagccccg attacagtca
     5701 gctcgccacg tgacaaagca ggtttaatga tatcagccaa tcctttgcca ccatcttcac
     5761 caccagtggc gcccgtgccg ataatctgat gaatttcatc gaagaataga ataatattac
     5821 cagctgcttt aacttccttt actagctgtt taatattttc ttcaaaagaa ccgcgatatt
     5881 gagttcctgc ttccaaagac gataaatcaa tcgaatagat ttctttatct tgaatcgttt
     5941 ctggaacttt accagccaca attgcttgtg ccagaccttc gacgactgca gttttaccta
     6001 caccagcatc accaactaag attggattat ttttcgtcct acgactcaaa atttctgcag
     6061 tttcttgaat ctcattctca cgtccaatca ctggatctag taatccatca cgagcctgtt
     6121 ccgtcaaatt agtccctaac ttttctaaaa tccccccttt tttaacagcc tgtttaccat
     6181 ctttagatac ttctattgtt ttattatttt ggggtagctt accagttgct cggtattgag
     6241 caaactcatc cggtgtcagc gattgtccat taactaaata ccgtgcacgc tccgaatttt
     6301 gattatccat gcgccgaaat aattgattga aaacatcatc catatcattg ttgaaaaaag
     6361 gatcatttcc gtagaaattt gccatattac aacacctcca taaaaattta tatgtgtaac
     6421 ttagtgacca taatatcctt taaaactaca actgaatcgt atcacgattt ttatgtatcg
     6481 ttaagtaaag tgcttataga atcaattaga aataattaga ataattttgt ttaaacaaaa
     6541 gagaaatcaa tttcataaaa tgaattgatt tccctacaag gttccctatt taatagccct
     6601 tgataaagaa cttgaattaa caagttactt tccagaccaa ttttaattta agagactgcg
     6661 actcaaaaag cacacccagt atcaagttaa ggccaactag ttatcgttaa tattgccact
     6721 taaatatcaa tactagcaat catgatacac gtgtaaaatc ataaaccaaa acatattaca
     6781 tgacgtaacg gcggtcttgg gactgtaaac tcacagtaat gattctattg agttggataa
     6841 ggtgccgatg accagtaatt gccataaatg caattgcttt cggtacaatc gtagtgacat
     6901 agccaactgt ctcggccatc tgcccatttg ttttataaaa ccgtaatgag actcgacatt
     6961 tttgatcatg cgcttgttgt aatttacaat aattattttc aacactcaaa ttaaagtctc
     7021 ccgttcaaag aattcaggtt tatttattcg tcagtgaatc tatgtgtttg tttttctcat
     7081 tgttgacggc gtaagtccac attaaggagt cagctattca gtaaaaacta aataactagt
     7141 attcatgttc agctcagtat aatatgcatt gatggttact aatcaaaaat cgatctctaa
     7201 atatcctaat tactatgaaa ctttgaagtt aatttatgag aaaaataact cacaacaaaa
     7261 ctcatgatta caaccttgtc atcataacta gattatgaaa cattcagcct cctaaataaa
     7321 actggtatgc gcgcatgtgc gcatgtgtac agtatactat tgccaggtat gtctgaataa
     7381 ccgttttaag acttgaaaaa ctcagctggg tgctttagga cgctttttgt gcattttaag
     7441 acaatatcct aacttcaacg ccggcatagc ttcaattcgt caatcagtgt cttagttcct
     7501 cagctatttc tgttcagaac atcttcctat tacaataaaa agcgttgatc tcagcagaat
     7561 ttacttccac caaaaccaac gctaaagtgt tattatatca ggtattttaa attcatttca
     7621 gacattatat tcagcattac ttctactacc taagtaattt agcacgttta acatcttcaa
     7681 tcgtcttagt tcccgctagt tgcatatcga tcaacagctc atcattaagg tgactcacta
     7741 cggaagcgac accctgcgca ccacccaatg ctaatccata gataatcggc cgagcaagtg
     7801 ccaccagatc tgcaccattg gctaacgcct taaagacatg ggagccacgc cgaacaccgc
     7861 tatcaaaaat tgttgggacg cgcccattaa cggcttgcgc aatctcgtgt aaaacatcaa
     7921 aggaagctgg accaccattt aattgccgac cgccatggtt tgaaacatag ataccttgag
     7981 caccagcccc gattgctaac aaggcatctt ctggtgactg aatccccttc acaataactg
     8041 gtaaattcgt atattctgta atacgccgaa catcagctgg gctaatcttt tgcgccgcag
     8101 cagcatagat ttctatgata cctttccctt taccatcccc ttcgctgaac ttagtcaagt
     8161 tagccattgg gattggaaac tggaaattgt tgataatatc agcttcacga tacccgtcaa
     8221 ctgttgcatc aacagtcaaa atgattgcct tagcaccagc cttcactgct tcatccacta
     8281 aactctgatt gaaattccaa tccttgctca tatataattg gaaaaattgg ggcgcacctt
     8341 taccagctgc ggcagtatcc gcaattgacg ttgaagaata agtactctga gccatgagtg
     8401 ccccaacttg agccatccct tcagcagtcg cagcttcacc ccgtgcatgt gccaatcctt
     8461 gagcggccgc tggagccatc ataataggcg ttttgagatc tatgccaaaa gcctgagtct
     8521 gtgtgcttgg ctgttccata tccgtcaatg ctcgtggcac aatttgaaca tggttaaagg
     8581 ccattgtatt ctgctttaaa gtccattcgt cttctgaccc accactaata tagccaaagc
     8641 ctccgctcgg gatgatcttt ttagcagctg cttccaatga tggtaaattt aaaatcgtta
     8701 acttttgctc acgatcactc tgttcatatc cattaataac tgtcattata ctaatctcct
     8761 ttacataacc ctttataatt catttaataa ttggctaagt gccggttgat ccgcttcagc
     8821 gataccatat cgttcacgat acttagcaat cgtatctgca tcaaagtttt ctggatctac
     8881 tggaacaaaa ctagtatcaa ttggatcaac atttttaatt tttgcatcaa tcacaattgg
     8941 tagttgatta ccattctgct gtagttgagt aactttctga aacgttgctt tcaactcttt
     9001 aaggttagtc actttaaaac caatcgcacc catgttgtct gccatcttgg cccaatcagc
     9061 accaatcaag tcaatcccat acggcgcctg attagcgagt aacttttcat gttgaataaa
     9121 gcctaatact ttgttttcta aaaccacgtt aatgactggc aaatgatatt taacttccgt
     9181 tagtaagtct ggcatcacca tggcataacc accatcacca gaaatactcc aaacctgctt
     9241 cttaggataa ttcaattggg cggccaaacc tgctggcaaa ccaaaaccca tcgtgccata
     9301 ccaagccgac atcgtaaaag tctgttgctt attcaatggt aactgtcgga ttgcccattc
     9361 cgtattattc ccaacatcca gaccaaagac ggcatcatca gtagcattgt ctttaatagc
     9421 ttctagcacc ccttcagccg tcaaccctcc ttgatcatca gtagcaattg tcttgagcca
     9481 ccggttccag ttttgcttat cacgttgagc agctttcaag aacttagttg gcttaattgt
     9541 cacttcggat tgaagtaatg cttggaaaaa ttcttttgca tctgcaagaa cagtaatatc
     9601 agcatcatgt tgtttgccta aatctgctaa attattattg acttgaataa acttaattcc
     9661 ttgtgacaag taacgtgcaa atggaaagtt agtaccaaca aacaaaacta gatctgccgc
     9721 ttgcgagact tcaaaggcgg gtttagttcc tagtcgaccg cgagagccca tgaaattagg
     9781 atggtcagtt ggcataatac cagttgctgg agccgtcgac aaaaccggca aactaaattt
     9841 ttcagaaact gcgataactt cttgacgcgc attataggca cccttgccaa tccataaaac
     9901 agggtgttga gcagctttca aagccgctat cgtctgctga acgtcatcta atttcggcat
     9961 taagacctgt tgactgccgc taagtgaagc cgttttaaaa ccatcaaact caatatcttg
    10021 accagacaaa tcatctggaa taataacaac agaaaccgaa cgggtcgcgt atgctgatct
    10081 aattgcttca tcaaccacgt atggaatctg ttcagccgtt gtcacttgtt tatgaaattc
    10141 ggctacatct gcaaaaattg gatcttggtt catttcttga aagaagttcg tattcataat
    10201 ggatgttgct gattgaccga ctaaagctag caccggtacg tgatccatct tggcatcgta
    10261 taatccgttc aagagatgaa cggcgcccgg tcctgctgaa ccaaagctaa caccaatcgt
    10321 cccagttaat ttagcatctg ccgcggcagc taaagcacca acttcttcat gacgtacttg
    10381 aatatacttc aagtggtctt tctcttggta gaacccatct accgtgttat taatcgagtc
    10441 agctgtaata ccatagatat gatcaatgtt ccagtcgact aacacttgtg ccaatgcttg
    10501 tcctgcttta attttagtca tttccattat cctctttttg ttgttacttt tttgagcaca
    10561 actatatcct aaataaaaac ttgacccttg tcaagtcttt atcttaaatt atgcttgttg
    10621 ttgaacagcg ctaatgtcat caataatatc ttgcagcgtc actcgcgaca tacgtgcctc
    10681 agcactattc tgaatatcac aatagtattt ttccatcact cgcggaatta ccgacccgac
    10741 cggacacgtc tccgaagtat tatgatcaac gtttaaaaaa ttacgcttag ccaccactgc
    10801 tacatagata tctttcaagg taatatcatt gggcgaacaa gctaatgttg gtctagcaac
    10861 gccacgaacc gaagttaaca agcctgcttt tcttaactta ctcatcattc ttctgaccat
    10921 ggtaggatcc gtatttaaac tactagcaat atgctcactt ttcagctggt catcagtatg
    10981 caacgcaata tatgccataa tatgcgtcgc atcacttaat tgtgtattag ccatctagac
    11041 acctcccata tccatctcta ttgttactta ttttagcaca tctaacatga acataaaagc
    11101 gattaaggaa ataagttagg cttctttccc taatcgcaac ataagattat ttgataatct
    11161 ccattaattc aatcaaactt attcaagaca tcgatagtag ctgaatttaa aacccaccct
    11221 gtccaatttg atgttgcaaa tcatctaagc caaattgttt taaataagtt gaaagtggtt
    11281 gtaaatcttg agcttcatac cgttgtttaa atgcttcaat atcagctgcc gaactcgttg
    11341 ccgaatctaa acgaagcttt tcagcaggca gtggccgatc tcctgtaatc accgcatcaa
    11401 tcagaactgg ttcatgctga gcgattgctt tggcttgttc aaaaacatca ggtaattgct
    11461 caatcttatt aactcgaaaa gcttgcatgt gcacgccatc ggcaatctta ctaaaatcaa
    11521 tatcattgaa ttcaacgcca ataaaatcat tctgattagt atcttcctgc tcatctttga
    11581 taaatccata ttggcagttg gtgaaaacaa cattaatcac tggtaaatgg tattgaactt
    11641 gcgtcgccaa atcttgcatg gtcatcgaag cgccaccatc accggccaga ttaaacacct
    11701 gccgctcagg ataattaagt ttggcagcaa ttgctcccgg aataccaact cccatcgtag
    11761 caaataagtt agaagtaatg tgccgattgg acggcgttaa tttcaaatgt cgattcgcat
    11821 tcaaattgat atcaccaaca tcaatcgaat agattgcatc aggctccgca attttattaa
    11881 ccgcacgtag cacttgatat gcttgtaaag gcccttcctg cttatcttct aatgaagcta
    11941 gataagcccg ccaattttta acattggcta aattggcttg ccaccaaggt gtcgactccc
    12001 gttcagatac ctgtgctaaa attgcagcca gcgttttttg tgcatcagca agtaccgcaa
    12061 tatctgtttt atgtcgttta cctaacttag ctggatcaat atcaatttgt aagaaataac
    12121 gcgtattttt aaacgctttg gaaacttctg caaacggata attattacca acaaataaaa
    12181 caacgtcggc ttgcgcaagt gcctcattcg ccggtttttg tgccacccga ttagcagaac
    12241 ccaaataggc tggataacga tccgcgacaa tacccttagc tggatacgta ctcattaatg
    12301 gaattttcaa cgttttactc aattgttcga gttctttacc agccttacga gctccaatgc
    12361 catagtaaat aagtggccgt tcagctgcga gtaaagtctg tgtcaatctc gtcactgctt
    12421 gaacgtcggg ttctggtaat aacggcgttt gataactatt agcggaagca taccaatctt
    12481 cagctggaat ctgttgccat ggtaaatcga ctggaatttg cacaaccgca acaccttggt
    12541 gcgcgtaggc gcgtcgaatt gcttcgtcaa taacatgtgg caacgtggca gcattgacgg
    12601 ctgttacatt ataatctgca acgtccgcat aaatcggatt ctcattcatt tcttggaacg
    12661 tatccatgtt catcccagta gttccaaatt gaccaataag tgctagaaca gggacatggt
    12721 cttcacgcgc atcatataac ccattcataa gatgagtgcc accaggtccc gctgagccga
    12781 agcaaacccc gattttaccc gttagcttag catcagcagc ggcggccatt gcaccaactt
    12841 cttcatgccg tacttgaata taatggattc gatccctttc tgctgataat gcgtccataa
    12901 ttgaattaat tgaacctcca ggaataccat acaaatgatc tactccccaa gcttctaaaa
    12961 ctttaataac tgctgcacct gctagtatgt tagtttgttt tgtttgtttc ataaccataa
    13021 taaagccccc atttcatgca caatttaatt acgcacaatt taataaacga atattaccat
    13081 agcaaacgct tacattcaag tggtcataaa ctcatgcttt ttaccactta atcacgattc
    13141 aaacgcattg tagatcaaca acagcgctag tctgcttgcc ttgatgaacc accatcgctg
    13201 ttgaaagtta gtatctcata cattcatttt ttaaacaatt ttagtaatta gtgtatgttt
    13261 tacaggggca tacttccaac aatgtctgca tgtttagaag ctagccattc ttcgaaaact
    13321 aactaccgct ttcaaaacat gaccttaact caactcgaca cagagcaaaa taacatctgc
    13381 caagttaatt attcagctat aatccgtacc acgctaccaa ctttaaaatc aggataatcg
    13441 ccctgctcaa catataacgt cccaggcaat ttagcctcct ttgcacccgt aaaactaata
    13501 gccgtatggc ctaatcttcc aaggttagtc tggacttcac caccaactgc tgtaatttga
    13561 tagacttgat tgtcgacttc aagtttcatt cctgctgtga tttgctcact tattgggaca
    13621 acttcgataa taaagcaaga aggccgtaat gcgtctggag cttcatcacc aaataatact
    13681 gccatgccaa tcgatttaaa atcagcagat tccgcaccta tttctaagac ctttgttgaa
    13741 aagataattc tctcttttgt catcatacaa tacacctcaa accttctaaa aatttatttt
    13801 gaatataatc caaaacttgc aatccaagca ataaagaccc gcggaacgcc gttgataaac
    13861 cgactatata acactgatgg caccccaact tcaaccgtct tag
//
