LOCUS       gnlProkkaBMHIFOOA_22   17172 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|BMHIFOOA_22.
ACCESSION   gnlProkkaBMHIFOOA_22
VERSION     gnlProkkaBMHIFOOA_22
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 03:56:16
            Original ID  :: gnl|Prokka|BMHIFOOA_22
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 17172
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..17172
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[9697:10403]"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      9698..10403
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     cand_cluster    1..17172
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..17172
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="1"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     CDS             complement(3..290)
                     /locus_tag="ctg22_1"
                     /transl_table=11
                     /translation="MSSITYSERIKIETFCELGLSNIQMGVRLNRSPSTISYELSRCQP
                     YQAELAQTDAEYKRSRCGRKTKLSDELKQKILNHLRLSWSPGMIAHEFKLA"
     CDS             591..2402
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 490.6;
                     E-value: 1.1e-148)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg22_2"
                     /sec_met_domain="TPP_enzyme_N (E-value: 2e-44, bitscore:
                     141.5, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.2e-38, bitscore:
                     122.6, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVMKQTKQTNILAGAAVIKVLEAWGVDHLYGIPGGSINSIMDALS
                     AERDRIHYIQVRHEEVGAMAAAADAKLTGKIGVCFGSAGPGGTHLMNGLYDAREDHVPV
                     LALIGQFGTTGMNMDTFQEMNENPIYADVADCNVTAVNAATLPHVIDEAIRRAYAHQGV
                     AVVQIPVDLPWQQIPAEDWYASANSYQTPLLPEPDVQAVTRLTQTLLAAERPLIYYGIG
                     ARKAGKELEQLSKTLKIPLMSTYPAKGIVADRYPAYLGSANRVAQKPANEALAQADVVL
                     FVGNNYPFAEVSKAFKNTRYFLQIDIDPAKLGKRHKTDIAVLADAQKTLAAILAQVSER
                     ESTPWWQANLANVKNWRAYLASLEDKQEGPLQAYQVLRAVNKIAEPDAIYSIDVGDINL
                     NANRHLKLMPSNRHITSNLFATMGVGIPGAIAAKLNYPERQVFNLAGDGGASMTMQDLA
                     TQVQYHLPVINVVFTNCQYGFIKDEQEDTNQNDFIGVEFNDIDFSKIADGVHMQAFRVN
                     KIEQLPDVFEQAKAIAQHEPVLIDAVITGDRPLPAEKLRLDSAMSSAADIEAFKQRYEA
                     QDLQPLSTYLKQFGLDDLQHQIGQGGF"
     CDS             2575..3000
                     /locus_tag="ctg22_3"
                     /transl_table=11
                     /translation="MANTQLSDATHIMAYIALHTDDQLKSEHIASSLNTDPTMVRRMMS
                     KLRKAGLLTSVRGVARPTLACSPNDITLKDIYVAVVAKRSFLNVDHNTSETCPVGSVIP
                     RVMEKYYCDIQNSAEARMSRVTLQDIIDDISAVQQQA"
     CDS             3088..4836
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 471;
                     E-value: 8.7e-143)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg22_4"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.2e-41, bitscore:
                     132.4, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.8e-32, bitscore:
                     102.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKIKAGQALAQVLVDWNIDHIYGITADSINNTVDGFYQEKNHLK
                     YIQVRHEEVGALAAAADAKLTGTIGVSFGSAGPGAVHLLNGLYDAKMDHVPVLALVGQS
                     ATSIMNTNFFQEMNQDPIFADVAEFHKQVTTAEQIPYVVDEAIRSAYATRSVSVVIIPD
                     DLSGQDIEFDGFKTASLSGSQQVLMPKLDDVQQTIAALKAAQHPVLWIGKGAYNARQEV
                     IAVSEKFSLPVLSTAPATGIMPTDHPNFMGSRGRLGTKPAFEVSQAADLVLFVGTNFPF
                     ARYLPQGIKFIQVNNNLADLGKQHDADITVLADAKEFFQALLQSEVTIKPTKFLKAAQR
                     DKQNWNRWLKTIATDDQGGLTAEGVLEAIKDNATDDAVFGLDVGNNTEWAIRQLPLNKQ
                     QTFTMSAWYGTMGFGLPAGLAAQLNYPKKQVWSISGDGGYAMVMPDLLTEVKYHLPVIN
                     VVLENKVLGFIQHEKLLANQAPYGIDLIGADWAKMADNMGAIGFKVTNLKELKATFQKV
                     TQLQQNGNQLPIVIDAKIKNVDPIDTSFVPVDPENFDADTIAKYRERYGIAEADQPALS
                     QLLNEL"
     CDS             4863..5504
                     /locus_tag="ctg22_5"
                     /transl_table=11
                     /translation="MTVINGYEQSDREQKLTILNLPSLEAAAKKIIPSGGFGYISGGSE
                     DEWTLKQNTMAFNHVQIVPRALTDMEQPSTQTQAFGIDLKTPIMMAPAAAQGLAHARGE
                     AATAEGMAQVGALMAQSTYSSTSIADTAAAGKGAPQFFQLYMSKDWDFNQSLLDEAVKA
                     GAKAIILTVDATVDGYREADIINNFQFPIPMANLTKFSEGDGKGKGIMEI"
     CDS             5577..5963
                     /locus_tag="ctg22_6"
                     /transl_table=11
                     /translation="MKGIQSPEDALLAIGAGAQGIYVSNHGGRQLNGGPASFDVLHEIA
                     QAVNGRVPIIFDSGVRRGSHVFKALANGADLVALARPIIYGLALGGAQGVASVVSHLND
                     ELLIDMQLAGTKTIEDVKRAKLLR"
     CDS             6592..6825
                     /locus_tag="ctg22_7"
                     /transl_table=11
                     /translation="MSVENNYCKLQQAHDQKCRVSLRFYKTNGQMAETVGYVTTIVPKA
                     IAFMAITGHRHLIQLNRIITVSLQSQDRRYVM"
     CDS             7216..9330
                     /gene_functions="other (smcogs) SMCOG1223:ATPase (Score:
                     961.7; E-value: 5.4e-291)"
                     /gene_kind="other"
                     /locus_tag="ctg22_8"
                     /transl_table=11
                     /translation="MANFYGNDPFFNNDMDDVFNQLFRRMDNQNSERARYLVNGQSLTP
                     DEFAQYRATGKLPQNNKTIEVSKDGKQAVKKGGILEKLGTNLTEQARDGLLDPVIGREN
                     EIQETAEILSRRTKNNPILVGDAGVGKTAVVEGLAQAIVAGKVPETIQDKEIYSIDLSS
                     LEAGTQYRGSFEENIKQLVKEVKAAGNIILFFDEIHQIIGTGATGGEDGGKGLADIIKP
                     ALSRGELTVIGATTQDEYRNTILKNAALARRFNDVVINEPTAADTLRILQGVKKLYEKH
                     HHVVLPDDVLKAAVDYSIQYIPQRTLPDKAIDLIDMTAAHLAAKNSQTDVETLDQRVKK
                     LEAAKEAAVKSEDFTKAADIKKSIEETKQKIKKTDQKEKITATIDDVAQSVERLTGIPV
                     ADMGANDIEHLKNLDKRLKSKVIGQDEAVEMVAKAIRRNRAGFSEGDQPIGSFLFVGPT
                     GVGKTELAKQLALDMFGNKNAIIRLDMSEYADRTAVSKLIGTSAGYVGYEDNANTLTER
                     VRRNPYSIVLLDEIEKADPQVLTLLLQVMDDGRLTDGQGNVINFKNTIIIATSNAGFGN
                     EALSGDKQRDQSLMDKLAPFFRPEFLNRFNGIVEFSHLTKQDLSQIVDLMLADVQKTLA
                     KKSIKLEVTKAAKDWLMEQGYDEAMGARPLRRVIEQQIRDKVTDFYLDHLDVKNLKADL
                     VDAEIVISAA"
     CDS             9698..10294
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_9"
                     /sec_met_domain="AgrB (E-value: 2.7e-35, bitscore: 111.6,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKPEQKLLLYKLSDRLFAAIQKNLQLERRQALLVKLGIDTVLNV
                     IPKLIITIILALLLHELVPVLVFMGSFLVLRGFAYGRHLKSDLLCTILTIFVFVGVPYV
                     IGTGISEVYRLLLSLIFVIIISIFAPADTVKNPITSKSLRKKLKRRAIGLSLILSLLQI
                     VSNNYFGTIILIAMALAALLLMPYERRENYERKNV"
     CDS             10275..10403
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: TIGR04223"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_10"
                     /sec_met_domain="TIGR04223 (E-value: 1.2e-08, bitscore:
                     25.3, seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEKMYKVLSHLFQYVGTKQLVMCCHGILFETKIPDELKSKD"
     CDS             10413..11675
                     /locus_tag="ctg22_11"
                     /transl_table=11
                     /translation="MLMIVFQELSIYLIIKSLLRNIFFVRLFDVIFLSVCMLMSYIFLA
                     KLGISFSFLMLMMFIFFTWWYVRVLSGALCITFQVFIWSIMVDHICDILTRLMKVPNGY
                     VVVFVILSVVSLIFLNIVMDRTNFSPTFSNQSLNRITALLLMIIYLYIMLSEGLENQFQ
                     VILSNLIILSVVMGLVLVIYNEYLKNVRAKYEVQKQRIQIQNDTRYMNEIEAHYNELRR
                     FRHDYQNMLISIDEYLKTDDLEGLQEYYQKNLAPVSNRVLKEKYNLEDLSRVKVKSIKS
                     ILFSKLSYAQSQEIEVHFDLKEPLIDITVNELDLDIALGIMLDNAIEASVGHADGEIMS
                     AIFIEKNSTVFLIQNNVFEQLPPLWKLKEAGYSTKGKNRGIGLNSLSKIVNRNENMILE
                     TRVLGAVFLQHLTVKRVSQND"
     CDS             11668..12411
                     /locus_tag="ctg22_12"
                     /transl_table=11
                     /translation="MISVYICEDDPKQLQQIRQIITKVIVDQQLDISICLACQDPHELL
                     DKVNAQQPQKAIYVLDIALNSDINGIQLASQIRDMGRRSKIIFITTHTELSLMVFQYQV
                     EALDFILKDFPDSLYERFSKVLHVAQDRFQTDENDQDDYVQIKIGETVRSINVKSIIFF
                     ESSTSPHKIVVHLDDGELEYYGLLKDVPDLSPNFYRCHKSYVVNLKRIKSLDKHLRRLT
                     MANGEKVLCSAQANRYLAKWLAKKS"
     CDS             12767..13204
                     /locus_tag="ctg22_13"
                     /transl_table=11
                     /translation="MIRLYTQSSCHSSRVARQWLEAHGIEFKEKNFSVDSPTVQDLKRI
                     LSLTEHGVDDIISARSKDYPEIAPKLPEMPLNEALKLLCDHPKLLRRPIIISDSKIQVG
                     FNEDDIRQFIPRPVRRLKFNALLSRLDGNTGDHIINKRMVE"
     CDS             complement(13362..14816)
                     /locus_tag="ctg22_14"
                     /transl_table=11
                     /translation="MTEKLTTETGQPWANNEHSQTAGARGPVLMQDYNLLEKLAHFDRE
                     RIPERVVHAKGAGAKGFFELENDMGEYTKADLFNGVGKKTPVILRFSQVAGEKGYPDTV
                     RDVRGFALKFYTQQGNYDLVGNNTPVFFVNDPLKFPDFIHSQKRDPKTNRRTQNMQWDF
                     WAHSPESLHQVTYLMGDRGLPASYRTMNGYGSHTFKWVNQNGEQFWVKYHFISDQGVKN
                     MTAQAAEKAMSQDLDYLQDDLYDAIQEKNYPSWTMYVQILPYEEGLNYKWDIFDVTKVI
                     SHKDYPLIKVGKLTLNENPTNNFTDIEEAAMSPANFVPGIEPSPDKLLQGRLFSYKDAQ
                     RYRLGANFEDLPVNKPVVPVHNYERDGYMKINNQGAEVNYEPNALHGPEEVPDAALSPD
                     SVRGETRAQPYRYQVDYTTQAGDLYRLMSEPEQERLINTIKDALGQVTLPGVKELEIKQ
                     FYEADKNYGTRVANTLGMNIADIISD"
     CDS             15162..15407
                     /locus_tag="ctg22_15"
                     /transl_table=11
                     /translation="MHWLWVLIIGAIIGAIAGAITNKGKSMGWISNIIAGLVGSAIGEA
                     LLGSWGPQLAGMAIVPSIIGGVIVVAITSFVLTRMD"
     CDS             15424..15558
                     /locus_tag="ctg22_16"
                     /transl_table=11
                     /translation="MIKSILKFCLAATLIVSGVLIGGTVLTAKGIDNLGDKLQDKLHG"
     CDS             15753..16301
                     /locus_tag="ctg22_17"
                     /transl_table=11
                     /translation="MSKLIAKNVFQLPKMNLLVLTTSAFLLALDVILYKIAIGPAYFQL
                     SFGFLSMACIGYLYGPIWGGLLEMISDILSFTIFGSGAFQIAFLLTAFLGGFIDGLFLY
                     RKSVNWLSVVMTQILVMIFVSLMMDSWLISVLFGTNFKVLLLGRLARVIIQIPLQVIAI
                     FYFIKALEKRHVFDRMGLR"
     CDS             complement(16497..16868)
                     /locus_tag="ctg22_18"
                     /transl_table=11
                     /translation="MRLWHEQLIHQLPRQQLLGQHRELAALRGNGWGKNHATVNYVFKY
                     SPYKLYQFHVLVMDEMQLRGYHPNKIWYDPNYRGQFCPPYDHLTPIALTTPIYPEHNAS
                     YLAECVRNLAAKGIIMPTT"
ORIGIN
        1 gtagctagtt taaattcgtg agcaatcatt cctggtgacc agcttagacg taaatggttg
       61 agaatttttt gctttaactc atcgctcagc ttagttttcc gaccacatcg tgatcgcttg
      121 tattcggcat ctgtttgtgc taattcagcc tgataaggtt gacatcgaga taattcataa
      181 gaaattgttg acggtgatcg gttcagccga acgcccattt ggatattgga cagccctagt
      241 tcacaaaagg tttcgatttt aattcgttcg gaataggtta tactagacaa aagatcagct
      301 cctaaaagat gggtttgtgg taaacaccat tttaaaggaa gctgatcttt tttgtccgaa
      361 cagcgttcgg attaatttta caatctacca tgagatacta attttcaaca gcgatggtgg
      421 ttcatcaagg caagcagact agcgctgttg ttgatctaca atgcgtttga atcgtgatta
      481 agtggtaaaa agcatgagtt tatgaccact tgaatgtaag cgtttgctat ggtaatattc
      541 gtttattaaa ttgtgcgtaa ttaaattgtg catgaaatgg gggctttatt atggttatga
      601 aacaaacaaa acaaactaac atactagcag gtgcagcagt tattaaagtt ttagaagctt
      661 ggggagtaga tcatttgtat ggtattcctg gaggttcaat taattcaatt atggacgcat
      721 tatcagcaga aagggatcga atccattata ttcaagtacg gcatgaagaa gttggtgcaa
      781 tggccgccgc tgctgacgct aagctaacgg gtaaaatcgg ggtttgcttc ggctcagcgg
      841 gacctggtgg cactcatctt atgaatgggt tatatgatgc gcgtgaagac catgtccctg
      901 ttctagcact tattggtcaa tttggaacta ctgggatgaa catggatacg ttccaagaaa
      961 tgaatgagaa tccgatttat gcggacgttg cagattgtaa tgtaacagcc gtcaatgctg
     1021 ccacgttgcc acatgttatt gacgaagcaa ttcgacgcgc ctacgcgcac caaggtgttg
     1081 cggttgtgca aattccagtc gatttaccat ggcaacagat tccagctgaa gattggtatg
     1141 cttccgctaa tagttatcaa acgccgttat taccagaacc cgacgttcaa gcagtgacga
     1201 gattgacaca gactttactc gcagctgaac ggccacttat ttactatggc attggagctc
     1261 gtaaggctgg taaagaactc gaacaattga gtaaaacgtt gaaaattcca ttaatgagta
     1321 cgtatccagc taagggtatt gtcgcggatc gttatccagc ctatttgggt tctgctaatc
     1381 gggtggcaca aaaaccggcg aatgaggcac ttgcgcaagc cgacgttgtt ttatttgttg
     1441 gtaataatta tccgtttgca gaagtttcca aagcgtttaa aaatacgcgt tatttcttac
     1501 aaattgatat tgatccggct aagttaggta aacgacataa aacagatatt gcggtacttg
     1561 ctgatgcaca aaagacgctg gctgcaattt tagcacaggt atctgaacgg gagtcgacac
     1621 cttggtggca agccaattta gccaatgtta aaaattggcg ggcttatcta gcttcattag
     1681 aagataagca ggaagggcct ttacaagcat atcaagtgct acgtgcggtt aataaaattg
     1741 cggagcctga tgcaatctat tcgattgatg ttggtgatat caatttgaat gcgaatcgac
     1801 atttgaaatt aatgccatcc aatcggcaca ttacttctaa cttatttgct acgatgggag
     1861 ttggtattcc gggagcaatt gctgccaaac ttaattatcc tgagcggcag gtgtttaatc
     1921 tggctggtga tggtggcgct tcgatgacaa tgcaagattt ggcgacgcaa gttcaatacc
     1981 atttaccagt gattaatgtt gttttcacca actgccaata tggatttatc aaagatgagc
     2041 aggaagatac taatcagaat gattttattg gcgttgaatt caatgatatt gattttagta
     2101 agattgccga tggcgtgcac atgcaagctt ttcgagttaa taagattgag caattacctg
     2161 atgtttttga acaagccaaa gcaatcgctc agcatgaacc agttctgatt gatgcggtga
     2221 ttacaggaga tcggccactg cctgctgaaa agcttcgttt agattcggca atgagttcgg
     2281 cagctgatat tgaagcattt aaacaacggt atgaagctca agatttacaa ccactttcaa
     2341 cttatttaaa acaatttggc ttagatgatt tgcaacatca aattggacag ggtgggtttt
     2401 aaattcagct actatcggtg tcttgaataa gtttgattga attaatggag attatcaaat
     2461 aatcttatgt tgcgattagg gaaagaagcc taacttattt ccttaatcgc ttttatgttc
     2521 acgttagatg tgctaaaata agtaacaata gagatggata tgggaggtgt ctagatggct
     2581 aatacacaat taagtgatgc gacgcatatt atggcatata ttgcgttgca tactgatgac
     2641 cagctgaaaa gtgaacatat tgctagtagt ttaaatacgg atcctaccat ggtcagaaga
     2701 atgatgagta agttaagaaa agcaggcttg ttaacttcgg ttcgtggcgt tgctagacca
     2761 acattagctt gttcgcccaa tgatattacc ttgaaagata tctatgtagc agtggtggct
     2821 aagcgtagtt ttttaaacgt tgatcataat acttcggaga cgtgtccggt cgggtcggta
     2881 attccgcgag tgatggaaaa atactattgt gatattcaga atagtgctga ggcacgtatg
     2941 tcgcgagtga cgctgcaaga tattattgat gacattagcg ctgttcaaca acaagcataa
     3001 tttaagataa agacttgaca agggtcaagt ttttatttag gatatagttg tgctaaaaaa
     3061 agtaacaaca aaaagagggt aatggaaatg actaaaatta aagcaggaca agcattggca
     3121 caagtgttgg tcgactggaa cattgatcat atctatggta ttacagctga ctcgattaat
     3181 aacacggtag atgggttcta ccaagagaaa aaccacttga agtatattca agtacgtcat
     3241 gaagaagttg gtgctttagc tgccgcggca gatgctaaat taacggggac gattggtgtt
     3301 agctttggtt cagcaggacc gggcgccgtt catctcttga acggattata cgatgccaag
     3361 atggatcacg taccggtgct agctttagtc ggtcaatcag caacatccat tatgaatacg
     3421 aacttctttc aagaaatgaa ccaagatcca atttttgcag atgtagccga atttcataaa
     3481 caagtgacaa cggctgaaca gattccatac gtggttgatg aagcaattag atcagcatac
     3541 gcgacccgtt cggtttctgt tgttattatt ccagatgatt tgtctggtca agatattgag
     3601 tttgatggtt ttaaaacggc ttcacttagc ggcagtcaac aggtcttaat gccgaaatta
     3661 gatgacgttc agcagacgat agcggctttg aaagctgctc aacaccctgt tttatggatt
     3721 ggtaagggtg cctataatgc gcgtcaagaa gttatcgcag tttctgaaaa atttagtttg
     3781 ccggttttgt cgacggctcc agcaactggt attatgccaa ctgaccatcc taatttcatg
     3841 ggctctcgcg gtcgactagg aactaaaccc gcctttgaag tctcgcaagc ggcagatcta
     3901 gttttgtttg ttggtactaa ctttccgttt gcacgttact tgccacaagg aattaagttt
     3961 attcaagtca ataacaattt agcagattta ggcaaacaac atgatgctga tattactgtt
     4021 cttgcagatg caaaagaatt tttccaagca ttacttcaat ccgaagtgac aattaagcca
     4081 actaagttct tgaaagctgc tcaacgtgat aagcaaaact ggaaccggtg gctcaagaca
     4141 attgctactg atgatcaagg agggttgacg gctgaagggg tgctagaagc tattaaagac
     4201 aatgctactg atgatgccgt ctttggtctg gatgttggga ataatacgga atgggcaatc
     4261 cgacagttac cattgaataa gcaacagact tttacgatgt cggcttggta tggcacgatg
     4321 ggttttggtt tgccagcagg tttggccgct caattgaatt atcctaagaa gcaggtttgg
     4381 agtatttctg gtgatggtgg ttatgccatg gtgatgccag acttactaac ggaagttaaa
     4441 tatcatttgc cagtcattaa cgtggtttta gaaaacaaag tattaggctt tattcaacat
     4501 gaaaagttac tcgctaatca ggcgccgtat gggattgact tgattggtgc tgattgggcc
     4561 aagatggcag acaacatggg tgcgattggt tttaaagtga ctaaccttaa agagttgaaa
     4621 gcaacgtttc agaaagttac tcaactacag cagaatggta atcaactacc aattgtgatt
     4681 gatgcaaaaa ttaaaaatgt tgatccaatt gatactagtt ttgttccagt agatccagaa
     4741 aactttgatg cagatacgat tgctaagtat cgtgaacgat atggtatcgc tgaagcggat
     4801 caaccggcac ttagccaatt attaaatgaa ttataaaggg ttatgtaaag gagattagta
     4861 taatgacagt tattaatgga tatgaacaga gtgatcgtga gcaaaagtta acgattttaa
     4921 atttaccatc attggaagca gctgctaaaa agatcatccc gagcggaggc tttggttata
     4981 ttagtggtgg gtcagaagac gaatggactt taaagcagaa tacaatggcc tttaaccatg
     5041 ttcaaattgt gccacgagca ttgacggata tggaacagcc aagcacacag actcaagctt
     5101 ttggcataga tctcaaaacg cctattatga tggctccagc ggccgctcaa ggattggcac
     5161 atgcacgggg tgaagctgcg actgctgaag ggatggctca agttggggca cttatggctc
     5221 agagtactta ctcttcaacg tcaattgcag atactgccgc agctggtaaa ggtgcgcccc
     5281 aatttttcca attatatatg agcaaagatt gggattttaa tcagagttta ctggatgaag
     5341 cagtgaaggc tggtgctaag gcaatcattt tgacagttga tgcaacagtt gacggttatc
     5401 gtgaagctga tattatcaac aatttccagt ttccaatccc aatggctaac ttgactaagt
     5461 tcagcgaagg ggatggtaaa gggaaaggta tcatggaaat ctaggctgct gcggcgcaaa
     5521 agattagccc ggctgatgtt cggcgtatta cggaatatac gaatttacca gttattgtga
     5581 aggggatcca gtcaccagaa gatgccttgt tagcaatcgg ggctggtgct caaggtatct
     5641 atgtttcaaa ccatggcggt cggcaattaa atggtggtcc agcttccttt gatgttttac
     5701 acgagattgc gcaagccgtt aatgggcgcg tcccaataat ttttgatagc ggtgttcggc
     5761 gtggctccca tgtctttaag gcgttagcca atggtgcaga tctggtggca cttgctcggc
     5821 cgattatcta tggattagca ttgggtggtg cgcagggtgt cgcttccgta gtgagtcacc
     5881 ttaatgatga gctgttgatc gatatgcaac tagcgggaac taagacgatt gaagatgtta
     5941 aacgtgctaa attacttagg tagtagaagt aatgctgaat ataatgtctg aaatgaattt
     6001 aaaatacctg atataataac actttagcgt tggttttggt ggaagtaaat tctgctgaga
     6061 tcaacgcttt ttattgtaat aggaagatgt tctgaacaga aatagctgag aaactaagac
     6121 actgattgac gaattgaagc tatgccggcg ttgaagttag gatattgtct taaaatgcac
     6181 aaaaagcgtc ctaaagcacc cagctgagtt tttcaagtct taaaacggtt attcagacat
     6241 acttggcaat agtatactgt acacatgcgc gcataccagt tttatttagg aggctgaatg
     6301 tttcataatc tagttatgat gacaaggttg taatcatgag ttttgttgtg agttattttt
     6361 ctcataaatt aacttcaaag tttcatagta attaggatat ttagagatcg atttttgatt
     6421 agtaaccatc aatgcatatt atactgagct gaacatgaat actagttatt tagtttttac
     6481 tgaatagctg actccttaat gtggacttac gccgtcaaca atgagaaaaa caaacacata
     6541 gattcactga cgaataaata aacctgaatt ctttgaacgg gagactttaa tttgagtgtt
     6601 gaaaataatt attgtaaatt acaacaagcg catgatcaaa aatgtcgagt ctcattacgg
     6661 ttttataaaa caaatgggca gatggccgag acagttggct atgtcactac gattgtaccg
     6721 aaagcaattg catttatggc aattactggt catcggcacc ttatccaact caatagaatc
     6781 attactgtga gtttacagtc ccaagaccgc cgttacgtca tgtaatatgt tttggtttat
     6841 gattttgcac gtgtatcatg attgctagta ttgatattta agtggcaata ttaacgataa
     6901 ctagttggcc ttaacttgat actgggtgtg ctttttgagt cgcagtctct taaattaaaa
     6961 ttggtctgga aagtaacttg ttaattcaag ttctttatca agggctatta aatagggaac
     7021 cttgtaggga aatcaattca ttttatgaaa ttgatttctc ttttgtttaa acaaaattat
     7081 tctaattatt tctaattgat tctataagca ctttacttaa cgatacataa aaatcgtgat
     7141 acgattcagt tgtagtttta aaggatatta tggtcactaa gttacacata taaattttta
     7201 tggaggtgtt gtaatatggc aaatttctac ggaaatgatc cttttttcaa caatgatatg
     7261 gatgatgttt tcaatcaatt atttcggcgc atggataatc aaaattcgga gcgtgcacgg
     7321 tatttagtta atggacaatc gctgacaccg gatgagtttg ctcaataccg agcaactggt
     7381 aagctacccc aaaataataa aacaatagaa gtatctaaag atggtaaaca ggctgttaaa
     7441 aaagggggga ttttagaaaa gttagggact aatttgacgg aacaggctcg tgatggatta
     7501 ctagatccag tgattggacg tgagaatgag attcaagaaa ctgcagaaat tttgagtcgt
     7561 aggacgaaaa ataatccaat cttagttggt gatgctggtg taggtaaaac tgcagtcgtc
     7621 gaaggtctgg cacaagcaat tgtggctggt aaagttccag aaacgattca agataaagaa
     7681 atctattcga ttgatttatc gtctttggaa gcaggaactc aatatcgcgg ttcttttgaa
     7741 gaaaatatta aacagctagt aaaggaagtt aaagcagctg gtaatattat tctattcttc
     7801 gatgaaattc atcagattat cggcacgggc gccactggtg gtgaagatgg tggcaaagga
     7861 ttggctgata tcattaaacc tgctttgtca cgtggcgagc tgactgtaat cggggctacg
     7921 actcaagatg aatatcgcaa tactattttg aaaaatgcgg ctttggcacg gcgattcaat
     7981 gatgttgtga ttaatgaacc gacggccgct gacactttac gtatattaca aggtgttaaa
     8041 aagctgtacg aaaagcatca tcatgttgta ttaccagatg atgttttgaa ggcggctgtg
     8101 gattattcaa tccaatatat accacaacgc actttgccag ataaagctat cgatttgatc
     8161 gacatgactg cggctcattt agcggctaaa aattcgcaaa ctgatgttga gacattggat
     8221 caacgcgtta aaaaattaga ggcagctaag gaggccgccg ttaaatcgga ggactttaca
     8281 aaagccgctg atatcaagaa gtcgatcgag gaaaccaagc aaaaaattaa aaaaacggat
     8341 caaaaagaaa aaatcactgc cacgattgat gatgtggcac aatcggttga acgtttaact
     8401 ggtataccag ttgctgatat gggcgctaat gatattgagc acttgaaaaa tcttgataag
     8461 cgtctgaaaa gtaaggtaat cggtcaagat gaagcggttg aaatggtagc gaaggcaatt
     8521 cggcgtaacc gtgcgggctt ttcagagggt gatcagccaa ttggaagttt tctgtttgtg
     8581 ggcccaactg gcgtaggaaa gactgaatta gctaagcaat tagccttaga tatgtttgga
     8641 aataaaaatg cgattattcg gctagatatg agtgaatatg ctgatcgtac agctgtgtcg
     8701 aaattaattg gtacctcggc tggatacgta ggctatgaag ataatgctaa tactctaact
     8761 gaacgggttc ggcgtaatcc atattccatt gtattattag atgaaattga aaaggctgat
     8821 ccacaagtat taacgttact gttacaagtg atggatgatg ggcgcttaac ggatggacaa
     8881 ggcaatgtca ttaatttcaa aaatacgatt attatcgcta cttctaatgc tggctttggt
     8941 aatgaagcat taagtggtga caagcaacga gatcagtcat taatggataa attagcacca
     9001 tttttccgcc cagaatttct gaaccgattt aatggaatcg tggaattttc acatctgact
     9061 aagcaagact taagtcaaat tgtcgatttg atgttggcgg atgtacaaaa aacgttagcc
     9121 aaaaaatcca tcaaacttga ggtaactaaa gcggccaaag attggctgat ggaacaaggc
     9181 tatgatgaag caatgggtgc gcggccatta cggcgagtaa ttgaacaaca aattcgtgac
     9241 aaggtaacgg atttctacct tgaccactta gatgtcaaaa acttgaaggc tgatttagtg
     9301 gatgctgaga ttgtgatatc ggcagcttag cttaaatcag tgttcataaa taactttatg
     9361 taagaggaga ttgcttgata gatctccttt tttcgttgat tttcaccatt tgatattaat
     9421 ctattgagta atgtgaatta gtgaaattaa gtctagtttg acttgtaatc taaggaaaaa
     9481 ttaaggggga gtatcgatga aactgattta tattaacgat ctttttatat gaaactttag
     9541 tttcgtatga ataattaaac tgatgtatct ttaaatgttt atttctagtc ttaaaacaat
     9601 attgaataat taatctattt atgtattctt ttcaattaat taatactgtt ttaaactgtt
     9661 gatacaggta tgtatttgag cattatagga gtgggatatg gaaaagccag aacaaaaact
     9721 attgctttat aaattaagcg accggttatt cgctgcgatt caaaagaatc ttcaactaga
     9781 aagacggcag gcattactag ttaaactagg cattgatact gtattaaatg ttattcctaa
     9841 gctgataatt actattatct tagcgttgct gctacacgag ttggtcccag tgttagtttt
     9901 tatgggtagt tttttagttt tgcgtggctt tgcctatgga cgtcacttga aatcggattt
     9961 gttatgtacg atattaacta tctttgtgtt tgtgggtgtg ccgtatgtga ttggaactgg
    10021 tatttctgaa gtatacagat tgttattaag tttaatattt gtaataatca taagtatttt
    10081 tgctccagct gatacggtaa agaatcctat tacatcgaag tcattgagaa aaaaattaaa
    10141 gcgacgggca attggattgt cattaatttt gagtttgtta caaatagtta gtaataatta
    10201 ttttggcaca atcattttaa ttgcgatggc attagccgct ttattactaa tgccctatga
    10261 aaggagggaa aattatgaaa gaaaaaatgt ataaagtact tagccatctt tttcaatacg
    10321 taggtactaa acagttggtt atgtgctgcc atgggatatt attcgaaact aaaattcctg
    10381 atgaattaaa aagcaaggat tagtgtagat atatgttaat gattgtcttc caagaattat
    10441 ctatctattt gataattaaa tctttgttga gaaatatatt ttttgtgaga ctttttgatg
    10501 ttatattttt atccgtctgt atgctgatga gttatatttt tttagcaaag ttaggaatta
    10561 gtttttcttt tttaatgtta atgatgttta tatttttcac ttggtggtat gtacgagttc
    10621 taagcggtgc actatgtata acatttcaag tgttcatatg gtcgattatg gttgaccata
    10681 tttgtgatat attaactcgt ttaatgaaag ttcctaatgg gtatgtggta gtgtttgtca
    10741 tattgagtgt cgtaagctta atttttctta atattgtaat ggatcgcacg aatttcagtc
    10801 ccacatttag taatcagagc ttaaatcgca taaccgcact attattaatg ataatatact
    10861 tgtatattat gttgagtgaa ggtctggaaa atcagttcca ggttatatta agtaatttaa
    10921 ttatattgtc agttgtaatg gggttagtat tggtgattta taacgaatat ttaaaaaatg
    10981 taagagccaa atatgaagtc caaaagcaaa gaatacaaat acaaaatgat actcgctata
    11041 tgaatgaaat cgaagctcac tataatgagt tgcgacgttt cagacatgac tatcagaata
    11101 tgttgatttc gatagatgaa tatttgaaaa ctgatgattt agaaggttta caagaatatt
    11161 atcaaaagaa tcttgcaccg gtttcaaatc gggtgttaaa agaaaaatat aatcttgaag
    11221 atttgagtcg ggtcaaagtg aagtcgatta agagtatcct atttagtaag ttgagctatg
    11281 cacaatcgca agagattgaa gttcattttg atttaaagga accattaatt gacattactg
    11341 ttaatgaatt ggatttagac attgcattag gaattatgtt ggataatgca attgaagcat
    11401 cggtaggaca tgctgatgga gagattatga gtgccatttt tatcgaaaaa aatagtacgg
    11461 tgttcttgat tcaaaacaat gtttttgaac agttaccacc cttatggaag ctgaaagagg
    11521 caggttattc cactaagggc aagaatcggg gaattggatt gaatagttta agtaagattg
    11581 ttaatcgcaa tgagaacatg atactcgaaa ccagagtctt aggagcggta ttcttacaac
    11641 acttgacggt gaagcgagta tctcagaatg attagtgtct atatttgcga agatgatccg
    11701 aaacaattac aacaaatacg gcaaatcatt actaaggtaa tcgtcgatca acagctagac
    11761 ataagtatct gtttagcatg ccaagatccc cacgaattgt tagacaaggt taatgcacag
    11821 cagcctcaaa aggcaatcta tgtgttagat attgccctta attcagatat taatggtatt
    11881 caactagcta gccagattcg tgacatgggc cggcgcagca agattatttt tatcacgaca
    11941 cacacggagt tatctttgat ggtgtttcaa tatcaagttg aggcattaga ttttattctt
    12001 aaggattttc cagattcctt gtatgagcga tttagcaagg ttttacacgt ggcacaagat
    12061 cgttttcaaa ccgatgaaaa tgaccaagac gactatgttc aaataaaaat tggtgagacg
    12121 gtcagatcaa ttaatgttaa aagcattata ttttttgaaa gttcaaccag tccccataaa
    12181 atcgtagtcc atttggatga tggtgaatta gaatactatg gactgttaaa ggacgttcct
    12241 gatttgagtc ctaatttcta tagatgtcat aagtcatatg ttgttaactt gaaacgcatt
    12301 aagtcattgg acaagcactt gcgacgatta accatggcaa atggtgaaaa agtgctttgt
    12361 tctgcacaag ctaatcgtta tctagctaaa tggcttgcta aaaagtcata atagttccaa
    12421 ggaagtcgcc tgccaaatta gtaggcgact ttttatgtgc tacgtgatga aaattcagcg
    12481 ttattcgatt agaaattgca gtggtatttg tcagcattac gtgtactggg ttcgttcttt
    12541 cctaaaccgt ttaaaagtgt acttaaaacg attatcctca gattattcgt cttaaaacgg
    12601 tcggtatgtc ccttgttcag agcctataat aaagatgtgt tcacggggta ttggattggt
    12661 catgacagta acgaatgcgt ttagtttaaa ggatgttgtg acaggcagaa gttaatgtcg
    12721 atcaatacgc tgtgatgaat tttaacgaga gaggggcaga ttaggaatga ttaggttata
    12781 tacacaatca agctgtcatt cttctagagt tgcacggcaa tggttggaag cacatgggat
    12841 tgagttcaag gagaaaaatt ttagtgttga ttcgcccacg gtgcaagatc taaaacgtat
    12901 tttgagttta accgaacatg gtgtagacga tattatctca gctcgatcta aagactatcc
    12961 tgaaattgcg cctaagttac ccgaaatgcc attgaatgag gcacttaaat tgttgtgtga
    13021 tcatccgaag ttgttacgtc ggcctatcat cattagtgat agtaaaattc aagttggctt
    13081 taatgaagat gatattcgcc aatttattcc acgaccagtt cggcgactaa agttcaatgc
    13141 attgttgagt cgtctagatg gtaatacagg ggatcacatt attaataaaa ggatggtcga
    13201 gtagtaagct atatctaaga ttttttgtta attaaagagc gacgggctag acttacacga
    13261 tatgagtcta acctgtcgct ctttagttaa taaccatgag acggcatcat cattctttat
    13321 aacaaaaata atatcgcgat ggataacatc cggtcaaaat attaatcact gataatatca
    13381 gcaatattca ttcccagagt attagccacg cgtgtaccgt agtttttgtc ggcctcataa
    13441 aattgcttga tttcgagttc tttgacacca ggcaaagtaa cttggcctaa cgcatctttg
    13501 atagtattaa ttaagcgttc ttgctcgggt tctgacatta agcgatatag gtcgcctgct
    13561 tgagttgtgt aatcaacttg atagcgataa ggctgtgcgc gtgtttcacc acgaacagaa
    13621 tcaggtgaaa gtgcggcatc cggcacctct tctggcccat gaagtgcatt aggctcgtag
    13681 ttgacctcag caccttgatt attaattttc atgtaaccat cacgttcata attatgaact
    13741 ggaacaaccg gcttgttcac gggtaaatct tcaaagttgg cacctaaccg atatcgctgt
    13801 gcatctttat aggagaatag gcgaccttgt agtaatttgt cgggagatgg ttcgatacca
    13861 ggaacaaaat ttgctggcga catggccgcc tcttcaatat cggtaaagtt attagtggga
    13921 ttctcattta aagttagttt gccgacttta attagtggat agtctttgtg ggagatgact
    13981 ttagtgacat caaaaatgtc ccatttatag tttagacctt cctcatatgg caagatttgg
    14041 acatacatcg tccatgatgg gtaatttttt tcttgaattg catcatataa gtcatcttgt
    14101 aaataatcta aatcttggct cattgctttt tcagctgctt gagcagtcat atttttaacg
    14161 ccttggtctg agatgaagtg atacttaacc caaaactgtt cgccattctg attaacccat
    14221 ttaaaagtat gggaaccgta accattcatg gttcgatagg acgcaggaag tcctcggtcg
    14281 cccattaaat aagtgacctg gtgcaatgat tctggagaat gagcccaaaa atcccattgc
    14341 atattttgtg tacgacggtt cgttttagga tcccgttttt gtgaatggat gaagtcagga
    14401 aattttaaag ggtcgtttac aaaaaagacc ggtgtgttgt ttccaacgag atcataattg
    14461 ccttgctgag tataaaattt taaggcaaaa ccgcgcacgt ctcgaacggt gtcaggataa
    14521 cctttttcac cggcaacttg tgagaacctt aagattacgg gagttttctt accgacacca
    14581 ttaaataagt ctgccttagt atattccccc atgtcgtttt caagttcaaa aaaacctttt
    14641 gctccggccc ccttagcatg aacgacccgt tctggaattc gttcacgatc aaaatgggct
    14701 agtttttcca aaagattata gtcttgcatt aatacgggac cacgagctcc tgccgtttgg
    14761 gaatgttcat tgttagccca tggttggccg gtttccgtcg ttaatttttc cgtcatttta
    14821 atcgcccttt tcacgtaaat tacaagaaag ctcttgcaca atttaaacgc taacacctta
    14881 acagagtgac ttcaatcatt atgcacagtt aagttaatcg ttcatgtggc gtagtttaat
    14941 tttaatcagc tatcaagctg tttgatattt tctaggccac ccggaatcgt cacatgagaa
    15001 atagtagcga cccatttatt aaataatgtg ttatatttgt ctatcattat cgataattgt
    15061 aaaatgataa ttataagaag taatcattta tgaatcggct taaatattcg tgtaattcta
    15121 ttattgtatt taagcgggtt aataagtcta ggagggattt tatgcattgg ttatgggttt
    15181 tgatcattgg tgctattatt ggtgcaattg caggtgctat tactaataaa ggtaaatcga
    15241 tggggtggat tagtaatatt attgccggat tggttggatc tgcaattggg gaagctcttt
    15301 tgggatcatg gggaccacaa ttagccggaa tggcaattgt tccttcaatt attggtggtg
    15361 tgattgttgt tgcgataacc tcatttgttc tgacacggat ggattagtaa ggagatgatt
    15421 gcgatgatta aaagcatttt aaagttttgt ttagctgcaa ccttaatcgt aagtggtgtt
    15481 cttattggtg ggaccgtact tactgctaag ggaattgata acttgggtga taaattacaa
    15541 gataagttac atggataaaa attaatttta caatgagcca ctgatgggtg tactagttga
    15601 cctgttagtg gcttttagta tgagtaatat cattgagttc aaggaactaa atcaagagcg
    15661 acgattttaa actaccttca atcgaataaa agtaatattt acttttatta agaatgaggg
    15721 tatgattaaa atcaaaaaaa gaggattgtc ctatgtctaa acttattgcg aaaaatgttt
    15781 ttcagttgcc aaaaatgaat ttattagtgc tgactacatc ggctttctta ttagccttag
    15841 acgttatttt atacaaaatt gctatcggac cagcgtattt tcaattatct tttggctttt
    15901 tgtctatggc ttgtattggt tatctatatg gtcccatttg gggtggtctc ttggagatga
    15961 tctccgatat attaagcttt actatttttg gttccggcgc gtttcagatt gcctttttgt
    16021 taactgcatt tttaggggga tttattgacg gtttgttttt atatcgtaaa tcagtcaatt
    16081 ggttatccgt tgtgatgacg caaatacttg taatgatttt tgttagtctg atgatggact
    16141 catggctgat ttcagtacta tttggcacta attttaaagt gttattgttg ggaagattgg
    16201 cacgcgtcat cattcagata ccattacagg tgattgctat tttttacttc attaaggcgt
    16261 tagaaaaacg acacgttttt gatagaatgg ggcttagata acatcgatgg atgccacaaa
    16321 aagaggttga acatggtatg aaatgcgcta caatcgttaa acaaataagt ctaacttttc
    16381 tattgcactt caagtctagt tcaacctttt ttaatattaa ctggccttat tatgactgcg
    16441 gaaaaacaat ttgggtatcg atggttgagt tggtacccag caaaataaaa gagcggctat
    16501 gtggtgggca tgataattcc cttagcagct aaattgcgga cacattctgc taagtagctg
    16561 gcgttgtgtt ctggatagat tggtgttgtt aatgcaatag gagtgaggtg atcataaggc
    16621 gggcaaaact gcccacgata atttggatca taccatattt tattaggatg atagccgcga
    16681 agttgcattt catccatcac taatacatga aattgataca acttgtaagg ggaatatttg
    16741 aaaacataat taacggttgc atgattttta ccccaaccat tgcctctcaa tgcggcaagc
    16801 tcacggtgtt gacctagtaa ttgttgtcgt ggtaattgat ggattaattg ttcatgccat
    16861 agacgcatag gccacactcc cttatcgaat tttaaaatta acaggtgaat attaaaagga
    16921 ccaactcatc attatgatgc cgaatatact gatacttttg aacgggtgat gattgtaaac
    16981 gacggatagt taaagtgaat attcgcaatt attatagcat agcgaattga tcaatagttt
    17041 agtacaaggt agattgcaaa tttaatccga atttttggac aaatttgtca gcataacctg
    17101 atacggtgtt tgccagtcga gtattttaag cggtcgctgg ttaatttgga gtaacgtcgt
    17161 cgttaaatct tg
//
