LOCUS       gnlProkkaHEGJHBCJ_25   13971 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HEGJHBCJ_25.
ACCESSION   gnlProkkaHEGJHBCJ_25
VERSION     gnlProkkaHEGJHBCJ_25
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 00:49:16
            Original ID  :: gnl|Prokka|HEGJHBCJ_25
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13971
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13971
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[1187:8971]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1188..8971
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..13971
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13971
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             147..671
                     /locus_tag="ctg25_1"
                     /transl_table=11
                     /translation="MSEQQKYWFAARTRDKQEFAIRDSLEKLKTELDLNYYLPTQFVIR
                     QLKYRRKRVEVPVIKNLIFIQATKQDACDISNKYNIQLFYMKDLLTRAMLIVPDKQMQD
                     FIFVMDLDPNGVSFDNDHLSVGSRVQVVKGDFCGVEGELASEANKTYVVIRIAGVLSAS
                     VKVPKSYLRVI"
     CDS             675..1157
                     /locus_tag="ctg25_2"
                     /transl_table=11
                     /translation="MNTLTSQIEQLQSLAHELLYLGVDGAPIYTDHFRQLNKEVLEQSD
                     ALYPQRGATPEEEANICLALLMGYNATIYNQGDKEEKKQVVLNRCWDVLDQLPATLLKC
                     QLLTYCYGEVFEEELAKEAHTIIESWKDKELSEDKKEAINNLRNLEENPYPYSEME"
     CDS             1188..2081
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 268.8; E-value:
                     9.4e-82)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg25_3"
                     /sec_met_domain="NTP_transf_3 (E-value: 5.9e-13, bitscore:
                     41.5, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKGIVLAGGSGTRLYPITKGVSKQLLPIFDKPMIYYPISVLMLAG
                     IREILIISTPYDLPGFQRLLGDGSDFGVHFEYAEQPSPDGLAQAFIIGEKFIGSDSVCL
                     VLGDNIFYGQGFTRMLREAVHSAESENKATVFGYWVSDPERYGVAEFDQEGNVLSIEEK
                     PQIPKSHYAVVGLYFYPNKVVEIAQNIKPSPRGELEITTVNQQFLLDQELKVKLLGRGF
                     AWLDTGTHDSLSEASTFIEVIEKRQGLKVACLEGIAFRQGWISSEKMKVLAQPMLKSQY
                     GQYMLKMIDITTSNEE"
     CDS             2254..3294
                     /locus_tag="ctg25_4"
                     /transl_table=11
                     /translation="MIYMFTRMIRSLLSRSPLYVLALYASVLIFLVYTCAYAYRKPFTA
                     AIYEGEILWGFDVKILYVLSEIIGYALSKFIGVRILPSMKAGHRIYYIIGLLTFSEVAL
                     LGFALLPVPLKVCSIFLSGLPLGMIWGVIFSYIEGRRISEILNVGLSVALIVSSGLVKT
                     LGQFVMDNLHVSEYWMPFTTGLLVYPVMLLCSWLLNQIPAPNEQDIIQRTKRAPMDGKD
                     RRKFLRQFFWGICMLVVFYGALTVFRELRDSFAADIWKELHIEGAMIFTQTEVPIAVFV
                     LVLMFLIVFVRNNRLALNIIYCIAVTGGSLMVFSTLLYVYGFLSPIWWMILSGLGLYMG
                     IFLSLT"
     CDS             3237..3557
                     /locus_tag="ctg25_5"
                     /transl_table=11
                     /translation="MDDSFRSWSVYGYIPFTYLIERLIASLRVVSTAVFIIYLADSFGY
                     LGTTGVFMVKNFVSADISWTVMLMRTALFSGFVSVLSIFAIYCYFKQQLNSLILIPSEI
                     HD"
     CDS             3571..4269
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg25_6"
                     /sec_met_domain="NTP_transf_3 (E-value: 7.5e-14, bitscore:
                     44.4, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAGLGTRFGHYTELVPKGFVEVGGKPMIIRSIETLLSCGIERII
                     LGTGYKKEAYEALQADFPQIETCFSPRYADTNSMYTLYNTRDVIGDDSFLLLESDLVFE
                     RKAILSLLDDEFPDVMLVSSLTKFQDQYYVEYDRNHILTSCSVDKDALEAKGELVGIHK
                     LSNTFYRRMCADYATILESQPKLGYEYELLRMSRSVSPVRVLRVEGLKWYEIDDEADLS
                     YAEEHIIRYC"
     CDS             4313..5590
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 214.4;
                     E-value: 3.3e-65)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg25_7"
                     /sec_met_domain="CTP_transf_like (E-value: 3e-12, bitscore:
                     39.1, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 1e-121, bitscore:
                     397.5, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 1.9e-64, bitscore:
                     209.5, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTADIMHPGLIHIIHEATKYGDVIVGLLTDKAIAEHKRLPYLTYD
                     QRKEVVENIKGVCEVVPQEDWSYVPNLEKLKPDYIIHGDDWKTGPLREVREQVFEVMNA
                     QGGKVIEIPYTRGINSSSLDKDIKAIGTTPDVRLKSLRRLIQAKPMVRILEAHDGLCGL
                     IIENLEVQKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNILECTTKPII
                     FDGDTGGKIEHFVFTVRTLERHGISAVIIEDKVGLKKNSLFGTDAIQTQDSIEGFCDKI
                     RAGKNAQVTGDFMIIARIESLIAGKPMSDALERAYAYVQAGADGIMIHSKDKSGEDIRE
                     FCRTFRKEYAHVPIVVVPTTYDHVHESELHEWGANVVIYANHLLRAAYPAMMNVARTIL
                     ENERAEEVRPLCMPIKEILELIPGTK"
     CDS             5602..6738
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 71.8;
                     E-value: 7.9e-22)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg25_8"
                     /sec_met_domain="TPP_enzyme_N (E-value: 9.9e-22, bitscore:
                     69.4, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.6e-20, bitscore:
                     64.8, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVSVEKIYDTFLHHGVDFFTGVPDSLLKNICAYITDHAPRGKHII
                     AANEGSAVGIACGYYMASGNVPLVYMQNSGLGNTVNPLLSLADEKVYSLPLLLLVGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMKIPFIILDTDEDEALAQIHDAVVSAKSRSIPHAIV
                     IRKDTFGKYKLRQEALNDYPLSREEALMQVVDHLGDNDIVVSTTGKLSRELFEYRESKG
                     QGHARDFLTVGSMGHSSSIALGVALEKPDRRVYCLDGDGAFIMHMGAVSNIGDLSPKNY
                     RHVLFNNGAHESVGGQPTLGFRLDIASIAKGCGYAHVLTASDKEGLSCALEKLSGLSGP
                     VLLEIKVRIDSRDDLGRPTTTPVENKEHFMAFLKDTHS"
     CDS             6735..7859
                     /NRPS_PKS="Domain: Aminotran_5 (30-301). E-value: 6.1e-34.
                     Score: 109.3. Matches aSDomain:
                     nrpspksdomains_ctg25_9_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 80.4; E-value:
                     2e-24)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg25_9"
                     /sec_met_domain="Aminotran_5 (E-value: 5e-31, bitscore:
                     100.0, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIERKILLNPGPATTTDTVKLAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGDLSKHTAVLFCGSGTINIDICLNSLLPADKKVLVVNNGAYSTRAVEVCEYY
                     GLPHIDLKFSVYELPDLSVIEKTLSDNPDIALVYTTHHETGTGILNPIREIGKIAHSHG
                     AVFVVDTTSSLGMIPFDIGKDNVDFCMASAQKGLQAMTGLSFIIGDESLIRASRDYPKR
                     SYYCNLYLQYDYFEKTGEMHFTPPVQTVYAARQALDEYFAVGEEAKFARHKRVFEAIHK
                     GLQELGLQYAIKREWQSGLVVSVLYPDDPLWDFDKVHDYCYERGFTIYPGKISTTNTFR
                     LCALGEIDVEDIERFFEVMREAISFLKISFKNIV"
     aSDomain        6825..7637
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg25_9_Aminotran_5.1"
                     /evalue="6.10E-34"
                     /label="ctg25_9_Aminotran_5.1"
                     /locus_tag="ctg25_9"
                     /protein_end="301"
                     /protein_start="30"
                     /score="109.3"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGDLSKHTAVLFCGSGTINIDICL
                     NSLLPADKKVLVVNNGAYSTRAVEVCEYYGLPHIDLKFSVYELPDLSVIEKTLSDNPDI
                     ALVYTTHHETGTGILNPIREIGKIAHSHGAVFVVDTTSSLGMIPFDIGKDNVDFCMASA
                     QKGLQAMTGLSFIIGDESLIRASRDYPKRSYYCNLYLQYDYFEKTGEMHFTPPVQTVYA
                     ARQALDEYFAVGEEAKFARHKRVFEAIHKGLQELGLQYAIKREWQSGLV"
     CDS             7862..8971
                     /NRPS_PKS="Domain: Aminotran_1_2 (37-163). E-value:
                     1.2e-06. Score: 19.8. Matches aSDomain:
                     nrpspksdomains_ctg25_10_Aminotran_1_2.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056:DegT/DnrJ/EryC1/StrS aminotransferase (Score:
                     279.5; E-value: 7.3e-85)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg25_10"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 2.2e-94,
                     bitscore: 308.7, seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_1_2 (E-value: 1.4e-06, bitscore:
                     19.8, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEENQITVTSPLLPSLDDFLPYLEDIWKRKWITNNGYYHQELEKA
                     LCQYLKVPYISLFTNGTLPLICSLQALRITGEVITTPYSFVATTHALWWNGIKPVFVDI
                     DPKTCNIDPNKIEAAITPKTTAIMPVHVYGNPCDFIAIQDIADKYGLKVIYDAAHAFGV
                     EVDGKSLLEFGDMSTLSFHATKVYNTIEGGALVCHDRQIKERVDFLKNFGFAGETQIVA
                     PGINGKIDEIRSAYGLLNLKVVDSAIEYRHQISKRYREGLGGIDGISYMPEMHNIRHNY
                     SYFPIFIDSVKYGITRDELYEKMKRNGVCGRRYFYPLITNFSTYCGLDSAQISNLPVAN
                     RIANSVICLPLHTGLTSIDVERIIELLKK"
     aSDomain        7973..8350
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg25_10_Aminotran_1_2.1"
                     /evalue="1.20E-06"
                     /label="ctg25_10_Aminotran_1_2.1"
                     /locus_tag="ctg25_10"
                     /protein_end="163"
                     /protein_start="37"
                     /score="19.8"
                     /tool="antismash"
                     /translation="YHQELEKALCQYLKVPYISLFTNGTLPLICSLQALRITGEVITTP
                     YSFVATTHALWWNGIKPVFVDIDPKTCNIDPNKIEAAITPKTTAIMPVHVYGNPCDFIA
                     IQDIADKYGLKVIYDAAHAFGV"
     CDS             8968..9516
                     /locus_tag="ctg25_11"
                     /transl_table=11
                     /translation="MTSFYSEKELANIGLAVYGTNVLISRKVSFYSPKNIYIGNNVRID
                     DFCILSGKILIGSNIHISAYVAIYGGYGVVLEDYVGISPRTTIYSAMDDFSGDYLVGPI
                     HDKRLTHVIGGEVRICKFAHIGANTIVYPGCSIGEGTVVGAMSMVRKSLDAWGVYIGIP
                     AKFLKNRNKNMQSLIYGKE"
     CDS             9503..10447
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg25_12"
                     /sec_met_domain="Glycos_transf_2 (E-value: 3.7e-21,
                     bitscore: 67.8, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGKNNRIPLVSVCCMTYNHDKFISQCLDGIIQQKGNFSIEILIHD
                     DASSDHTRQIIEFYRDKYPDIIKPLYQEINQYSRGVNIWNTYMFPLVKGEYIAICDGDD
                     YWIDQYKLEKQITFLQKYADYNLVYTNKIVINELGTRVIRNHPKYLSGNLFVNLLSGGN
                     PITTSTVCIRTHDAFEIMDIVNSIPFRTVMGDLQLWLALAIKGKFKYLAFKSTVYRLSS
                     ISLSHSLSVNREIRFSKHEYFIKKYFADIFQVNIDKKILERTYYKNTIRRLFSFRKEIF
                     LSYVFKSVKKDPFLIFDIKIITLVGVKLLKSIL"
     CDS             10444..11610
                     /locus_tag="ctg25_13"
                     /transl_table=11
                     /translation="MKVLLVFIDMMRTDLLSVYNQNVKDKTSFDLLLEKIGGCIYTNCY
                     TPAPDTPRSLACLQTGLHPYFNGCNTRIKWPKYYVKEEIDTIFDILSNNKILINYYAPK
                     VDLDTGALSIKEGSVVNLFTNIEKFTSNILQSTCDEMDFLTLDDYHWAIDDYGATHKAV
                     KIGHNIISNVLNTFFRTHSYDEFDHIFFFSDHGHKLENEIALMESALELLRDDRAKILM
                     VHRSKRNSGLSIDNRLCSIQDLYATILSIFHLNYDHRDSLSLLSTSKSDVHDHLIIEDH
                     ADFTVSLNQVISVWRYISDVGSFYTNVCKYSKEGYCELSNSTIISLIQQKSPTYLDYER
                     QMLILKEYSKMSEKYCTYSNGGKRLGRKKQVLLKVKNKCYRFLIKCFR"
     CDS             11607..12863
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg25_14"
                     /sec_met_domain="Polysacc_synt (E-value: 1.5e-12, bitscore:
                     39.6, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRSRFIELITVTASSIIELSTTLLITKIVAVQLSKDGYGFYSLIL
                     SVVALFSLLPFSSLHVGIERYIIEYKNRNKFARFYASIYLIHIVFFVLYLLLLLPLSPF
                     LTGEWNEIWEIVYLFFITKVYKQFVFCILNINRKRISILYARIIDLSIQLILLYFFLIK
                     GLSIQEILYASIVSSLLTIGYLVYIDSHNIYLKKVRVSDFLLVLKDVFSYSYPLIIWGI
                     FAWIQSMIGRWFVDFYLTKSDVANFSMIFSLSLLPSTAISAIIGSYFVPIAYSNEAKST
                     GFIGRYINKILFAVSLVWLVIILTFLFLGEYIIVLFLDVKYLNIYWYLFWGLLGTGVYT
                     LGQLSVYELYYYKKVKYLLLPNLLPGLLTIVGCMIIVPFWGFDGAVYVNVFTYVISGIL
                     TLYCTLYYGRKIKIIYGNC"
     CDS             12850..13722
                     /locus_tag="ctg25_15"
                     /transl_table=11
                     /translation="MVIAKLFGGLGNQMFIYAAAKGIAQISNQKLTFDIYTGFEDDSRF
                     RRVYELKQFNLSVQESRRWMSFRYPLGRILRKISRKIGFCIPLVNFKFIVEKKPYHFQN
                     EIMRIASFSSIYLEGYFQSYKYFSKIEAQIREDFKFTKEVIGSVEKEASFITNSRYTPV
                     AIGVRRYSEMKGEFGELAVVEHDYYDAAIKYIANKVPNLIFIVFSEDIDWVKKNLKLDY
                     PVYFVTSKKGELAAIQDMYLMSLCNHHIISNSSFYWWGAYLASTNNHIVIAPSVFLNKD
                     CTPIDWVII"
ORIGIN
        1 acgaacgttt tttgaaacac attcgttcgt tctcaacttc taaaaatgtt tcgtaaaatt
       61 tgacggtttg aaagagaaaa gatgtctcgt tcaaaccgcg aagcgcaccc gaaacaaagg
      121 aaaatttccc caagtataaa tcgtaaatgt ctgaacaaca gaagtattgg tttgccgccc
      181 gtacccgaga taaacaagag tttgctattc gtgactctct tgaaaaattg aagactgaac
      241 ttgatctcaa ttactatctt cccactcagt ttgtcatccg gcagttgaaa tatcgtcgaa
      301 aacgggtgga agtccctgtt attaagaatc ttatcttcat ccaagctacc aagcaagatg
      361 cttgtgatat ttctaataaa tacaatatcc agctttttta tatgaaagac ctgcttacca
      421 gggccatgct gatagttcct gataaacaga tgcaggactt catatttgtc atggatttag
      481 atccgaatgg cgtcagtttc gataatgacc atttatctgt tggtagcagg gttcaggtag
      541 ttaaaggtga tttctgtggt gtcgagggcg aacttgccag cgaggccaac aaaacttatg
      601 ttgttattcg tattgccggt gtattgagcg ccagcgtcaa agttcctaaa agttatttac
      661 gtgtcattta agttatgaat acactcactt ctcaaattga acaattacag agtctcgcgc
      721 acgagttact ctatttaggt gtggatggtg ctcctattta taccgatcat ttccgtcagt
      781 tgaacaaaga agttttagaa caatccgatg cgttgtatcc tcagcgcggt gctactcccg
      841 aagaggaggc aaacatttgt ctggcattat tgatgggtta caatgcaacc atctataatc
      901 agggtgacaa ggaggagaaa aagcaagttg ttctcaatcg ttgttgggac gtgcttgacc
      961 aacttcctgc tactttattg aaatgccagt tgttgactta ttgttatggt gaggtgtttg
     1021 aagaggagtt ggcgaaagag gcgcatacta tcatagaaag ttggaaagat aaagaacttt
     1081 ctgaagataa aaaagaggca atcaataatt tgagaaattt ggaagagaat ccatatcctt
     1141 atagtgaaat ggaatagaat aattctattt ttttatttat ttgacttatg aaaggcattg
     1201 ttttagctgg gggatctggt acacgtttat atcctattac taaaggagta agcaaacaac
     1261 ttcttccaat tttcgataaa cccatgattt attatcccat ctctgtactt atgttagctg
     1321 ggatacgaga aatactaatt atctctactc cttatgactt accgggtttt caacgtttac
     1381 tgggcgatgg ttctgatttt ggagtacact ttgagtatgc agagcagcct tctcctgatg
     1441 gtttagcaca agcatttatt attggagaga agtttattgg cagtgattct gtttgtttag
     1501 ttttaggaga taatattttt tatgggcaag gttttacgcg catgttgcgt gaagcggttc
     1561 attctgctga atcagaaaac aaagcaaccg tttttggtta ttgggtaagt gatcctgaac
     1621 gttatggcgt tgcagagttt gatcaggagg gaaatgtact cagtattgaa gaaaagcctc
     1681 aaatacctaa atcacattat gctgttgtag gactttattt ctatcctaat aaagtggtgg
     1741 agatagccca aaatatcaaa ccttctcctc gtggagaatt agaaataact actgttaatc
     1801 aacagttttt gttagaccag gaactgaagg tcaaattatt agggcgtggc tttgcttggt
     1861 tggatacagg tacgcatgac tcgctgtccg aagcgagcac ttttatcgaa gtgatagaaa
     1921 aacgtcaagg gctgaaagtt gcttgtttag agggaattgc ttttaggcaa ggttggattt
     1981 cttccgagaa gatgaaagta ttggcacaac cgatgttaaa gagccaatat gggcaatata
     2041 tgttgaagat gattgatata acgacctcta atgaggaata gatgcctgaa ttagatagta
     2101 aaaaaattaa taatactgac ttcttcaaat atagctaatc cttataattc tttatttatg
     2161 gataaataga tttctgagtg ttttttattt agcgaataga atatttttac attcagccct
     2221 gttaaatcgt aatttgaatt gtcgttacat tggatgattt atatgtttac acgaatgatt
     2281 cgttcccttc tttcccgttc tcccctttac gttttggctc tctatgccag cgttttgatt
     2341 tttctggttt atacctgtgc ctatgcctac cgtaagccat ttaccgcagc catttatgaa
     2401 ggtgagattc tttggggatt cgatgtcaaa atcctgtatg tcctttctga gattatcggc
     2461 tacgcccttt ccaagttcat cggtgttcgt attctgcctt cgatgaaagc gggtcaccgc
     2521 atctattata taatagggct gcttactttt tccgaagttg ctttgttggg ttttgcactt
     2581 cttccggttc ctttgaaggt gtgttctatt tttctgagcg gtcttcccct gggtatgatc
     2641 tggggtgtca tttttagcta tatcgaaggg cgtcgtatca gtgaaatatt gaatgtcggg
     2701 ctgagcgttg ctttgatagt ctcttccggt ttggtgaaaa ccttgggaca attcgtgatg
     2761 gataatttgc atgtgtcgga atattggatg ccttttacca ccggtttgtt ggtataccct
     2821 gttatgttgc tttgcagctg gcttctcaat cagattccgg ctcccaatga gcaagatatc
     2881 atacagcgta ccaaacgtgc tccgatggat ggtaaagaca ggcgtaagtt tttgaggcaa
     2941 ttcttttggg gaatctgcat gctggttgtt ttttacggtg ccctgaccgt gttccgtgag
     3001 cttcgtgact ctttcgctgc cgatatttgg aaggagctcc atattgaggg tgcaatgatc
     3061 tttactcaga cagaggttcc cattgccgtt tttgtccttg tactgatgtt cctgattgtg
     3121 tttgtccgta ataaccgttt ggctcttaat atcatttatt gcatcgccgt cacaggcggt
     3181 tccttaatgg ttttttccac attgctttat gtgtacggtt ttctttctcc tatttggtgg
     3241 atgattcttt ccggtcttgg tctgtatatg ggtatattcc tttcacttac ctgatagaac
     3301 gtctgattgc ttcccttagg gtggttagta cggctgtttt tattatttat ttggccgatt
     3361 ctttcggcta tctgggcact acgggtgtgt ttatggtcaa gaacttcgtt tctgctgaca
     3421 tttcctggac tgtcatgctg atgcgtactg cccttttttc aggatttgtt tctgtcctgt
     3481 cgatttttgc gatttactgt tatttcaagc aacaattgaa ttcacttata ttaattccct
     3541 ctgaaattca tgattaaaac agcaatgatc atggctgccg gtcttggtac ccgcttcggg
     3601 cattataccg agcttgtgcc caaaggtttt gtggaggttg gtggaaaacc tatgattatc
     3661 cgctctatcg aaacccttct ttcctgcggt atcgaacgta tcatcctcgg tacgggttat
     3721 aaaaaagagg cttatgaagc ccttcaggcg gatttccccc agatagagac ctgtttcagt
     3781 ccccgttatg ccgatactaa cagtatgtac actctgtaca atacgcgtga cgtgataggc
     3841 gatgacagtt tcctgctgct tgaatcggac cttgtttttg aacgcaaggc catcctctcg
     3901 ctgctggatg acgaattccc ggatgtgatg cttgtctctt ctctgaccaa gttccaggat
     3961 cagtattatg tggaatatga ccgcaatcac atccttactt cctgttcggt agacaaggac
     4021 gcccttgagg caaaaggcga gctggtcggt atccataaac tttccaatac tttctaccgc
     4081 cggatgtgcg ccgattatgc gaccatcctg gagtcccagc ctaaactggg ttacgagtac
     4141 gaactgctcc gcatgtcccg ttccgtttcc cctgtccgtg tgctcagggt ggagggtctt
     4201 aaatggtatg aaatcgatga tgaagccgac ctttcgtatg ctgaggagca catcatccgc
     4261 tattgttaaa aacaaatctt ttccatatat gaacaagaaa atctatgtcg gtatgaccgc
     4321 ggatatcatg catccggggt tgatccatat tattcatgaa gctactaaat acggtgatgt
     4381 catcgtcggt ctgctgacgg acaaggccat cgccgaacac aaacgcctcc cttaccttac
     4441 ctatgatcag cgtaaggagg ttgttgagaa tatcaaaggg gtttgcgaag ttgttcccca
     4501 agaggattgg agctatgttc cgaatctgga aaaactcaag cctgactata tcatccacgg
     4561 tgacgactgg aaaacgggcc cgttgcgcga ggtgcgcgaa caggtttttg aggtgatgaa
     4621 cgcccagggg ggcaaggtaa tcgagatccc ttatacccgg ggcatcaact cctcctcgct
     4681 cgacaaggat atcaaggcga tcgggactac ccctgacgta cgtcttaagt ccctccgccg
     4741 tctgatccag gccaagccta tggtccgtat cctggaggct cacgacggtc tttgcggtct
     4801 gattattgag aatcttgaag tccagaaggg tgataagcgc gaggtctttg acggcatgtg
     4861 gtccagcagc ctgaccgact ccacgagtaa gggtaaaccg gatattgaag cggtcgacct
     4921 taccacccgt ttacaggacc tgaacaatat ccttgaatgt accaccaagc ctattatttt
     4981 tgatggagac acgggtggca agatcgaaca ctttgtcttt actgtgcgca ctctggaacg
     5041 tcacggcatt tctgcggtaa tcattgaaga taaagtcggt ctgaagaaga attctctttt
     5101 tggtactgac gctatccaga ctcaggatag tatcgagggt ttctgcgata agatcagagc
     5161 agggaagaat gcccaggtca ccggtgactt tatgatcatt gcgcgtatcg aaagccttat
     5221 tgccggcaaa cccatgagtg acgccctcga acgtgcttat gcctatgtac aggcgggtgc
     5281 ggacggcatc atgatccaca gcaaggataa gtcgggtgag gatatccgtg agttctgccg
     5341 gactttccgc aaagaatacg cccatgttcc cattgtcgtt gttccgacga cttatgacca
     5401 tgtgcacgaa tccgaacttc acgaatgggg tgccaacgta gtcatttacg ccaaccacct
     5461 tctccgtgcc gcttacccgg ccatgatgaa cgtggccagg accatccttg aaaacgagcg
     5521 cgccgaggag gtccgtccgc tttgtatgcc tatcaaggaa attctggaat tgattccggg
     5581 cactaaataa atcagacggt tatggtaagt gtagaaaaga tatacgatac gttccttcat
     5641 cacggtgttg acttctttac gggtgttccc gattcccttt tgaagaatat ttgcgcctat
     5701 atcacggatc atgctccgcg tggtaagcat atcatcgccg ccaatgaagg ttccgcggtg
     5761 ggcattgcct gcggttatta tatggcttct ggcaacgttc ctttggttta tatgcagaac
     5821 tccggtctgg gaaatacggt gaatcccctc ttgtcccttg cggacgagaa agtgtacagc
     5881 cttcctcttc ttttgctggt cggttggcgc ggtgagcccg gcacgaaaga cgaaccccag
     5941 cataagaagc agggcgaggt tacccttgat cttctgaaag ccatgaaaat tccttttata
     6001 attctggata cggatgaaga cgaggccctg gcgcagatcc atgacgcggt tgtctcggcg
     6061 aagagccggt cgattcccca tgcgattgtc atccgtaaag atacgtttgg aaaatataaa
     6121 ttgcgtcagg aagccttgaa tgactatcct ctgtcccgcg aggaggcgct aatgcaggtt
     6181 gtcgaccacc tcggggacaa tgacattgtg gtttccacca cgggcaagct ctcccgtgag
     6241 cttttcgagt accgtgaatc gaaagggcag gggcacgcaa gggatttcct aactgtgggt
     6301 tccatggggc acagttcttc cattgcccta ggggttgccc ttgagaagcc tgaccgccgt
     6361 gtctactgtc ttgacggtga cggtgccttt atcatgcaca tgggtgctgt cagcaatatc
     6421 ggcgatcttt ctcccaagaa ttacaggcac gtccttttca ataacggtgc ccatgaatct
     6481 gtcggcggtc aacccacgct cggtttccgt ctggatatcg cctcgatagc gaaaggttgc
     6541 ggttatgcgc atgtactgac tgcctccgac aaggaagggc tttcgtgtgc gcttgagaag
     6601 ctgtccggcc tgtccggccc ggttcttctt gaaattaagg tccggatcga ttcacgtgat
     6661 gatctgggtc gccctacgac tactccggta gagaataaag agcattttat ggcattttta
     6721 aaagatacgc attcatgaat atcgaaagaa agatcctttt gaatccgggt cccgccacca
     6781 cgacggatac ggtgaagctg gcgcaggttg ttcccgatat ctgtccgcgt gagaaagagt
     6841 ttgcgggtat gatgaaacag ttacgtgacg acctggtccg cgttgcgcat ggagacctct
     6901 ccaaacatac ggccgtcctg ttttgcggct cgggtacgat caatatcgat atctgcctga
     6961 actctcttct tcctgcggat aagaaagttc tggttgtcaa taacggtgcc tacagcaccc
     7021 gtgcggtgga agtctgcgaa tattacggtc ttccccatat cgatttgaag ttttccgttt
     7081 acgaacttcc cgacctgtcg gtaatcgaaa agacgctttc cgacaatccg gacatcgctt
     7141 tggtctatac cacgcaccat gaaacgggta cgggtatctt gaaccccatc cgtgagatcg
     7201 gaaaaatagc ccattcgcac ggtgccgttt ttgttgtcga caccacttcc tccctgggta
     7261 tgattccttt tgatatcggg aaggataatg ttgacttttg tatggcttcg gctcagaaag
     7321 gccttcaggc catgacgggg ctttccttta tcataggtga tgaatccctg atacgtgctt
     7381 caagggatta tccgaaacgt tcctactatt gtaacctcta tttacaatac gattactttg
     7441 agaagacggg cgagatgcat tttactcctc ctgttcaaac cgtttacgct gcccgtcagg
     7501 ctcttgatga atattttgca gtaggtgaag aggctaaatt cgcccgtcac aagagggtct
     7561 ttgaagccat ccataaaggt ttgcaagagc ttggtcttca gtatgcgatc aaacgtgaat
     7621 ggcagtcggg tcttgttgtt tctgtattgt atcctgatga tcccctctgg gattttgata
     7681 aggttcatga ttactgctat gaacgtggct ttacgatcta cccgggtaag atttccacaa
     7741 cgaatacatt ccggctttgt gcgttgggag agattgatgt ggaggatatt gagaggttct
     7801 ttgaggtgat gagggaagca atttcatttc tcaaaatcag ttttaaaaat atagtttaat
     7861 tatggaagag aatcaaataa ctgtaacttc gcctttattg ccttctttag acgatttttt
     7921 accatattta gaggatatat ggaagcgtaa atggattacc aataatgggt attatcatca
     7981 agaattggag aaagctttgt gccaatactt gaaagtacca tacatctctt tgtttacaaa
     8041 tggtactttg cctttaattt gctctttaca agctttgaga attactggtg aagttataac
     8101 aacaccatac agctttgtag caacaacgca tgctttatgg tggaatggca ttaagcctgt
     8161 gtttgtggat attgatccta aaacttgcaa tattgatccg aataagattg aagcagctat
     8221 tactcctaag acgacagcta ttatgccagt tcatgtctat ggaaatcctt gcgattttat
     8281 tgctatccag gatattgcag ataaatatgg actaaaagtt atttatgatg cggctcatgc
     8341 ttttggagta gaggtagatg gaaaatctct tctagagttt ggagatatgt ccacactaag
     8401 ttttcatgca actaaggttt ataatacaat tgagggggga gcattagttt gtcatgaccg
     8461 gcagattaaa gagagagttg attttttgaa gaattttggt tttgctggtg aaactcaaat
     8521 tgtggctcct ggaatcaatg ggaaaataga cgagattcgt tctgcatacg gactacttaa
     8581 tttaaaagtt gttgattctg ctattgaata ccgacatcaa atatctaaaa gatatcgtga
     8641 gggattagga ggtattgatg gtattagtta tatgcctgaa atgcataata tacgtcataa
     8701 ttattcttat tttcctatct ttatagattc tgtaaagtat ggtattactc gtgatgaact
     8761 ttatgaaaaa atgaaacgaa atggtgtgtg tggtcggaga tatttttatc cattaataac
     8821 aaacttttca acgtactgtg ggcttgattc cgctcaaata agtaatcttc ctgttgcaaa
     8881 tagaatagct aactctgtca tttgtctgcc actacatact ggcttaactt ctattgatgt
     8941 tgaacgtata attgaacttt taaaaaaatg acatcttttt attcagaaaa agaattggca
     9001 aatataggtt tagcagtata cggcacaaat gttctgattt ctaggaaagt ctctttttat
     9061 tctcccaaga atatatatat aggaaataat gtacggatag acgatttttg tatattgtct
     9121 ggcaaaattc tcatcggttc caatatacat atatctgctt atgtagctat atatggagga
     9181 tatggagtgg ttttagagga ttatgtgggt atatctccta gaacaacgat ttatagtgca
     9241 atggatgatt ttagtggtga ttatttagta ggtcctattc atgataaaag attaactcat
     9301 gttattggtg gagaagttcg aatttgtaag tttgctcata ttggcgcaaa tactattgta
     9361 tatcccggat gttctattgg tgaaggaact gtagttggag caatgtctat ggttcggaaa
     9421 tcattggatg cttggggagt ttatattggt atacctgcta aatttctaaa aaatagaaat
     9481 aaaaatatgc aaagtttgat ttatgggaaa gaataataga attccattag tctctgtttg
     9541 ttgtatgacc tataatcatg ataaatttat ttctcaatgc ttagatggta ttattcaaca
     9601 aaaaggtaac ttctctattg aaatattgat tcatgatgat gcttcttctg atcatacacg
     9661 acaaataata gaattctata gagataagta tccagatatt ataaagcctc tatatcaaga
     9721 aattaatcaa tattctcggg gggttaatat atggaacact tatatgtttc cattggttaa
     9781 aggagaatat attgctatat gtgatgggga tgactattgg atagatcaat ataaattgga
     9841 gaaacaaata actttcttgc aaaaatatgc tgactataat ttggtttata caaataaaat
     9901 tgttataaac gaattaggaa ccagagtaat taggaatcat cctaaatatt tatcgggaaa
     9961 tttgtttgtg aatttgttaa gtggaggtaa tcctattaca acatctactg tatgtattcg
    10021 aactcatgat gcatttgaaa taatggatat tgtaaattct attccattta gaactgtaat
    10081 gggagattta caattatggt tagctttagc cataaaagga aagtttaaat atttggcttt
    10141 taaatctact gtctatagat tatcctctat ttctcttagc cattctttga gtgtaaatcg
    10201 ggaaataaga ttttcaaaac atgaatattt tattaaaaaa tattttgcag atatatttca
    10261 ggtaaatatt gataaaaaga tattggaacg aacatattat aagaatacaa ttcgtcgatt
    10321 attttcattt agaaaagaaa tttttttgag ttacgttttt aagtctgtga aaaaagatcc
    10381 attcttgatt tttgatataa agataataac attagtgggg gtgaaattat taaaatccat
    10441 tttatgaaag ttttattggt atttatagat atgatgagaa cagatttact atctgtatat
    10501 aatcaaaatg taaaagataa aacaagtttt gatttattgt tagaaaaaat tggtggatgt
    10561 atatatacta attgctatac accagctcct gatactccac gtagtttagc ttgtcttcaa
    10621 actggattgc atccatattt caatggatgt aatacaagaa ttaaatggcc taaatattat
    10681 gtcaaagagg aaatagatac tatttttgat attctttcta ataataaaat tcttattaat
    10741 tattatgctc ctaaagttga tcttgataca ggagcgttat ctataaaaga aggaagtgta
    10801 gtgaatctat ttactaatat tgaaaagttt acttcaaata ttttgcagag tacttgcgat
    10861 gaaatggact ttttaacatt agatgattat cattgggcca tagatgatta tggcgctacc
    10921 cataaagctg tgaaaatagg ccataatatt atttcaaatg tattgaatac cttctttaga
    10981 acgcattctt atgatgagtt cgatcacatt tttttctttt cagatcatgg acataaattg
    11041 gaaaatgaga tagctcttat ggaaagtgct ttagaacttt tgagagacga tagagctaaa
    11101 atcttaatgg tacaccgttc gaaaagaaat agtggtttgt ctattgacaa tagattatgt
    11161 tcaatacaag atttatatgc tactattcta tccatttttc atttgaatta tgatcataga
    11221 gattcgttat ctttattgtc tacttcaaaa tcagatgtac atgatcatct aataatagag
    11281 gatcatgcag attttactgt ttcgttgaat caggttataa gtgtttggag atatatttcg
    11341 gatgtaggtt cattttatac caatgtttgt aaatatagta aagagggata ctgtgaactt
    11401 tccaattcta caattatatc attaattcaa caaaaatcac ctacttattt agattatgaa
    11461 aggcagatgt tgatattgaa agaatattct aaaatgtcag agaaatattg tacctattca
    11521 aatgggggta aacgtttagg aagaaaaaaa caagttctac taaaggttaa aaataaatgt
    11581 tatagattct tgataaaatg ttttagatga gaagtcgatt tatagaatta ataactgtaa
    11641 cagcaagtag cattatagaa ttatctacga ctcttttaat aactaaaatt gttgcagttc
    11701 aattatctaa ggacggatat ggattttatt ctctcatatt atctgtagtg gctcttttct
    11761 ctttattacc attttcgtca ttgcatgttg gcattgaacg ttatattata gaatataaaa
    11821 ataggaacaa gtttgctaga ttttatgctt caatatattt aattcatatt gtcttttttg
    11881 tcttatattt gttgcttttg ttgcctctaa gtcccttttt aacaggggaa tggaatgaga
    11941 tttgggagat tgtatattta ttctttatta caaaagttta taaacagttt gttttctgca
    12001 ttttgaatat taatcgtaaa agaatttcta tattatatgc gagaataatt gatttaagta
    12061 ttcaacttat attattgtat ttttttctta taaaagggtt gtctattcaa gaaatattat
    12121 atgcttcaat agtgagtagt ttactaacta ttggatatct agtttatatt gattcgcata
    12181 atatctattt aaaaaaggtt agagttagtg attttttatt ggtattgaaa gatgtgttta
    12241 gctattcata tcctttaatt atatggggaa tttttgcttg gattcaatca atgattggac
    12301 ggtggtttgt tgatttttat ttaacaaaat ctgatgttgc taacttcagt atgatatttt
    12361 cattatctct gttgccatct actgcaataa gtgctattat tggtagttat tttgttccaa
    12421 tagcatattc aaatgaagcg aaatctactg ggtttattgg taggtatatc aataaaattc
    12481 tatttgctgt ttcacttgtg tggcttgtga ttatattgac tttcttattt ttgggtgaat
    12541 atattattgt acttttttta gacgtaaaat atttaaatat atattggtac ttgttttggg
    12601 ggttattagg gactggcgtc tatacattag gacagttgtc tgtgtatgaa ttatactatt
    12661 ataaaaaagt gaaatacttg ttgctaccta atctactacc gggccttttg acaattgttg
    12721 gatgtatgat tattgttcct ttttggggat ttgatggagc tgtatatgtg aatgtattta
    12781 cttatgtaat atcagggatt ttaactttat attgtacttt atattatggt cgtaaaatta
    12841 aaataattta tggtaattgc taaattattt ggaggattag gaaatcaaat gtttatttat
    12901 gcagctgcaa aaggtattgc acaaatttca aaccaaaaat taacatttga tatttatacc
    12961 ggctttgaag atgattctag gtttcggaga gtttatgaat taaaacaatt taatttgtct
    13021 gtacaggaat ctaggaggtg gatgtctttt cgatatccgc tagggagaat actgagaaaa
    13081 attagccgaa aaatcggatt ttgtattcct ttggttaatt ttaaatttat agttgaaaag
    13141 aagccatatc attttcaaaa tgaaataatg aggatagctt ccttttcttc aatttactta
    13201 gaagggtatt ttcaatcata taaatacttc tcaaaaatag aagcacaaat aagagaagat
    13261 tttaaattta ctaaagaagt tattggttca gttgagaaag aggcttcttt tataaccaac
    13321 tcacgatata caccggtggc tataggcgta cgccgttatt ccgagatgaa aggggaattt
    13381 ggtgaattag ctgtggtgga acatgattat tatgatgcgg ccataaaata tatagcaaat
    13441 aaagttccta atttaatttt tattgttttt tctgaagata ttgattgggt aaaaaaaaat
    13501 ttgaagttag attatccagt gtattttgtt acttctaaaa agggagagtt agcagctatt
    13561 caagatatgt atttaatgtc tttatgtaat catcatataa tttcgaatag tagtttttat
    13621 tggtggggtg catatttggc ttctacaaac aatcacattg ttatagctcc atctgttttc
    13681 ttaaataaag actgcactcc tatagattgg gtgattattt aattgtaagc tatttacttg
    13741 tcttttatta atagaaccac tgcactttta atttttttga ttgattttgt tgtttgttct
    13801 atttgacaag aattaatttt tatgtttttt atttatctta aatttcacat tatccattct
    13861 ttcttttgtc acctcaattt aagataaaat gtaattacga tttgtaactg tgagttctat
    13921 ttatgattag tttgtgtttt ttgggaaaga gttaatagag agctacatct t
//
