LOCUS       c00045_gnlPro..        13007 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CIOOLDEI_46.
ACCESSION   c00045_gnlPro..
VERSION     c00045_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2025-04-29 04:59:40
            Original ID  :: gnl|Prokka|CIOOLDEI_46
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13007
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13007
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[368:6832]"
                     /cutoff="10000"
                     /detection_rule="(Nitr_red_bet_C and Nitrate_red_del and
                     Nitrate_red_gam and Molybdopterin and minimum(2, [Fer4_11,
                     Molybdopterin, Molydop_binding, Nitr_red_alph_N]))"
                     /neighbourhood="10000"
                     /product="Nitrate_reductase"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      369..6832
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Nitr_red_bet_C and Nitrate_red_del and
                     Nitrate_red_gam and Molybdopterin and minimum(2, [Fer4_11,
                     Molybdopterin, Molydop_binding, Nitr_red_alph_N]))"
                     /neighbourhood="10000"
                     /product="Nitrate_reductase"
                     /protocluster_number="1"
     cand_cluster    1..13007
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Nitr_red_bet_C and Nitrate_red_del and
                     Nitrate_red_gam and Molybdopterin and minimum(2, [Fer4_11,
                     Molybdopterin, Molydop_binding, Nitr_red_alph_N]))"
                     /kind="single"
                     /product="Nitrate_reductase"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13007
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Nitrate_reductase"
                     /region_number="1"
                     /rules="(Nitr_red_bet_C and Nitrate_red_del and
                     Nitrate_red_gam and Molybdopterin and minimum(2, [Fer4_11,
                     Molybdopterin, Molydop_binding, Nitr_red_alph_N]))"
                     /tool="gutsmash"
     CDS             2..253
                     /locus_tag="ctg45_1"
                     /transl_table=11
                     /translation="SLNERNSELLESTILDYQKTNTEMDTAIQTLRQNRKYVLNSAKFE
                     YSNVPLEGINRKIKTLKRTCYGFANQKFFFLRIDCIFS"
     CDS             complement(369..1058)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Nitrate_reductase: Nitrate_red_gam"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg45_2"
                     /sec_met_domain="Nitrate_red_gam (E-value: 1.1e-77,
                     bitscore: 250.4, seeds: 140, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHNGWSIFLWVIYPYIMLASFFIGTFVRFKYFHPSITAKSSELFE
                     KKWLMIGSVTFHIGIILAFFGHCLGMFIPASWTAYFGITEHMYHIFGSLMMGIPAGILA
                     FVGIAILTYRRMTCSRVYKTSDINDIIVDWALLITIALGLACTITGAFIDYNYRTTISP
                     WARSLFVLNPQWQLMRSVPLIYKIHVLCGLAIFGYFPYTRLVHALTLPWQYIFRRFIVY
                     RRRARVY"
     CDS             complement(1051..1629)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Nitrate_reductase: Nitrate_red_del"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg45_3"
                     /sec_met_domain="Nitrate_red_del (E-value: 1.2e-09,
                     bitscore: 28.2, seeds: 108, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VIDFRRLTDLKDTFAVLSRLIDYPDTETFSPEIRQLLLADNALST
                     ATRGELLSLFDELAALSSIEVQEMYAHLFEMNRRYTLYMSYYKMTDSRERGTILARLKM
                     LYEMFGISEATSELSDYLPLLLEFLAYGDYTNDPRRQDIQLALSVIEDGTYTLLKNAVT
                     DSDNPYIQLIRLTRSLIGSCIKMEVREDA"
     CDS             complement(1622..3067)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Nitrate_reductase: Fer4_11"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Nitrate_reductase: Nitr_red_bet_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg45_4"
                     /sec_met_domain="Fer4_11 (E-value: 2.5e-39, bitscore:
                     123.4, seeds: 34, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 0.00041, bitscore: 10.9,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="Nitr_red_bet_C (E-value: 1.2e-28,
                     bitscore: 88.6, seeds: 110, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MWFNNVETKPGVGYPKRWEDEDQYHGGWTLNSKGKLKLRAGSKLN
                     KIALGKIFYNNDMPELDNYYEPWTYDYKTLFGPEQKHQPVARPKSQITGEGMELTTGPN
                     WDDDLAGSTEYVQQDPNMQKIEGDIKNNFEQAFMMYLPRLCEHCLNAPCVASCPSGAMY
                     KRDEDGIVLVDQERCRGWRFCMTGCPYKKVYFNWKTHKAEKCTFCYPRIEEGQPTVCAE
                     TCVGRIRYIGAILYDADRVEEAASTSDESKLYEAQLGLFLDPNDPEVVKQALKDGISEE
                     MIEAAQKSPIYKMAVKEKIAFPLHPEYRTMPMVWYIPPLSPVMSYFEGRDSIKNPEMIF
                     PGIDQMRVPVQYLASLLTAGNVPVIKKALYKLAMMRLYMRAKTSGRDFDSSKLERVDLT
                     EERATSLYRLLAIAKYEDRFVIPSSQKAEMEDAQTEQGSLGYDECEGCALAPQHKSMFK
                     KAEAGKSTNQIYADSFYGGIWRD"
     CDS             complement(3222..3794)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Nitrate_reductase: Molydop_binding"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg45_5"
                     /sec_met_domain="Molydop_binding (E-value: 8.5e-25,
                     bitscore: 76.9, seeds: 74, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTERNIPTFTLTGRQHFYIDHEIFREFGENMATYKPSLPPVVMAP
                     GDVDVPPVKDEVTLKYMTPHGKWNIHTMYYDNLEMLTLFRGGPTIWISPQDADKIKVKD
                     NDWIEVYNRNGVVTARAVVSVRMPEGSMYMYHAQDNEIYEPLSTITGNRGGSHNAPTQI
                     HVKPTHMLEDMPIELRLELLWTNWKPT"
     CDS             complement(3794..6832)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Nitrate_reductase: Molybdopterin"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Nitrate_reductase: Nitr_red_alph_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg45_6"
                     /sec_met_domain="Molybdopterin (E-value: 9.9e-143,
                     bitscore: 466.0, seeds: 32, tool: rule-based-clusters)"
                     /sec_met_domain="Nitr_red_alph_N (E-value: 7.9e-09,
                     bitscore: 25.9, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSRFFNKVDKFNGTFTQLEENSRRWEKLYRQRWAHDKVVRTTHG
                     VNCTGSCSWNVYVKQGIITWEHQATDYPSCGPNIPGYEPRGCPRGASFSWYEYSPVRIK
                     YPYIRGKLWELWTAAKKEHENPLDAWASIVEDPEKSKKYKKVRGHGGLIRVHRYEALEM
                     ISAACLYTIKKYGPDRIGGFTPIPAMSMMSFSAGARFIALMGGEQMSFYDWYADLPPAS
                     PQVWGEQTDVPESAEWYNSSYIIMWGSNVPLTRTPDAHFMTEVRYKGTKIVAVSPDYAE
                     NVKFADDWLAPEPGSDSAVAQAMTYVILDEFYQKHPVKRFIDYSKRFTDLPFMVELEPS
                     TANDAHYTPGRFVRISDLVDDDTIVNPAWKTVVYDQNNHKIVVPNGTMGQEYNAKEKWN
                     LELLDQNGNKIDPALSINDQGEETEQIIADFPAFSNDGNSVVQRHLPVKKLKFTDGQEH
                     LVTNVYDLMMAQMGINRTGNDELAAKDAMDAESYFTPAWQESRTGVKAEQVIQIAREFA
                     QNAAENEGRSMVIMGGGVNHWFNADMNYRNIINMLMLCGCVGMTGGGWAHYVGQEKLRP
                     QEGWANITFANDWEKGGARQMQGTTWYYFATDQWRYEEIDNQAQKSPVWKSKHSYLHNA
                     DYNQMAIRLGWLPSYPQFDRNPLSFAKDYNTTDIDEISKKVVDELKKGTLHFAAEDPDA
                     NQNQPKAFFLWRSNLFASSGKGAEYFMKHLLGAENGLLAKPNDRVKPQDMVWRDKGAIG
                     KLDLVVDMDFRMVSTPMYSDVVLPAATWYEKKDLSSTDMHPFIHPFNAAVSPMWESKSD
                     WQQFKLLAKTVSEMAKKYMSGTVYDLKSAPLGHNTQGEIAQPYGKIKDWKNGETEPIPG
                     KTMPSLKLVTRDYTKIYDKFITLGPNIVNNYGYKVDDQYDYLKGMNGTASEGIGAGCPL
                     LDEDEKVCDAILRMSTASNGKLADRAWEKKQERTGEHLTDIGRGHADDSMSFKQITAQP
                     QEAIQHQSELLLNMVGLDTHHSH"
     CDS             6978..7997
                     /locus_tag="ctg45_7"
                     /transl_table=11
                     /translation="MNRYDRQERVHQIGVVGQQKISHATIMIVGVGALGSYTAEQLVRA
                     GVKRLVLIDPDTVDVTNLQRQSLFTEADANQQRLKVEAAKEHLHKINSACQIIAIPAPI
                     TADLIDEYQFTLCLDCLDNYQARDLLNKLAIIKNFDYLFASCAGTYGNVMAISPQNYPC
                     LNCLFPNINELKQNDCDLIGVNTALIPIVAGLQVSLALHYLVDKTQVNFNELITVDNWS
                     MQFSKFIINKNSHCPACTNPSSISLEEESAPELHMLCGENAYYTVKEKPINFGRLKEFL
                     AKKELLINANRLFLHFKWENRPVSIFKNGKIVMYDLPTSAIAQKQFESLNTLMKEDLL"
     CDS             7994..8491
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MoCF_biosynth"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg45_8"
                     /sec_met_domain="MoCF_biosynth (E-value: 3.7e-34, bitscore:
                     107.4, seeds: 114, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKIAILTVSDSRTLDSDTSGKLIAMKMANAGLSVVDRVIVNDDI
                     VNIQTAYLQLEQQAIDIIITNGGTGVAQRDVTIPAIRPLLKRLIPGFGEAFRQISFDEI
                     GTRALASQALAGFNYRNQLTYCLPGSQNACQTALNKLILPEYEHLLFESSSQRKEVHHH
                     AH"
     CDS             8481..9698
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MoCF_biosynth"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MoeA_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MoeA_N"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg45_9"
                     /sec_met_domain="MoCF_biosynth (E-value: 2.2e-23, bitscore:
                     72.4, seeds: 114, tool: rule-based-clusters)"
                     /sec_met_domain="MoeA_C (E-value: 8.8e-14, bitscore: 41.5,
                     seeds: 41, tool: rule-based-clusters)"
                     /sec_met_domain="MoeA_N (E-value: 7.1e-40, bitscore: 126.2,
                     seeds: 1302, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLTRRTPISVAEAQKKINEIPLKTTTETIPLSEANHRILAEDVHA
                     HYDYPHFRRAGMDGYAILASDDHDFPREFNVRGEIQAGATWDQPLQPGDAVRIMTGAYV
                     PSDAGKVIRIEKTRPAEDKNKVQIITTESKTNITETGTDVKSGDIVLAKDQEINPGGLA
                     VLTAFGVQEVTVYKKPRIAIIATGTELLGPNETIEPGKIFNSNGIMLKNLVEETGGIVD
                     FETQLPDDANLIKQTLEEQIATHEIVITDGGVSVGDFDFIGDEARKADELLFNKIKQRP
                     GSVTTAFVQNNTLVMALSGNPGACFTGFYLYMEPLIRRYQHQASRIKRVRAILAAPYNK
                     TNGFDRYLRCTYEFKDDQFYVYPNGINRSGSLANLQTTTCLALIPHSTTPMKVGTETDA
                     WLLPFK"
     CDS             9677..10165
                     /locus_tag="ctg45_10"
                     /transl_table=11
                     /translation="MAITLQIIGHKKSGKTLITTALIERLSKEGYRVAALKHDAHNAAM
                     DVPTTDSARMSNAGANQVILQSPTEFFFHQKSNVPTLTEMVELLSDDNDFVLIEGHKEA
                     TQYPQILLLKPGEDPTNIAPTTPLKTGSIFSGTNADLLGKNTIVNWCYNYLKQIKENT"
     CDS             10165..10737
                     /locus_tag="ctg45_11"
                     /transl_table=11
                     /translation="MIGLVYAGGKSIRFGKDKATYHVPRLPATNVQLAVEKLMPLCQQI
                     IVCANETNRAHIIELVGQVPAVQIICDIPPYDHHGPLSAIIACTSQFSVVQDYLTLAVD
                     YPYITKDVLAILARTSNSYIVTSQHSHYSLAHFSISNEQVTTWVDNNSDWRLRSFITNK
                     CGCHPLAYRSSAEFSNLNYREVDLNEK"
     CDS             10727..11011
                     /locus_tag="ctg45_12"
                     /transl_table=11
                     /translation="MKSKDSMTNPDFQKLISLVLNDLTIRRTMLENREQEVNQQMSSLE
                     KDAKLEQLDDQIQQIQADFDHYREFQDPEFDFSATKYFQGPSMGLPRHP"
     CDS             11278..12216
                     /locus_tag="ctg45_13"
                     /transl_table=11
                     /translation="MLNLDVNYLLQIGKNAWSQLENDDCASCLIKKRLKGAAVPITFHS
                     NATHPFHFSMVYRPLDDKENVFALTLENSEQQQRLSQVEEQRILNQYVNEAHEKERQKI
                     SQDLHDSVAQGIYAAIMGIQRLATVQNPRNTEQFQSMSAAIEKQLQTTLKEIKELALDI
                     RPSVLDNFGLIPAIKALAKRLQNSTGITINVIALTSAEKLQKNIQNVLYRITQEAINNA
                     IKHAHSTEITIIVTNHNSYLQLEILDNGIGFDLEQHSRFNGHSLGLMNMNERVKAYNGA
                     FTITSKINKGTTVKVKFPYNNLNKDTVRTNV"
     CDS             12209..12391
                     /locus_tag="ctg45_14"
                     /transl_table=11
                     /translation="MYNVLVADDHAIVRSGISYLVDLQPNFTVVDGTASGTDTYIRVEP
                     GFSPVFRYSYRHSHF"
ORIGIN
        1 aagcctaaac gagcgcaata gtgaattact agagtcaacc atcttagact accaaaaaac
       61 caatacagaa atggataccg ctatccaaac ccttcgtcaa aacagaaaat atgtcttaaa
      121 tagtgctaaa tttgaatact ctaatgttcc tttagaaggc atcaatcgca aaatcaaaac
      181 tctaaaacga acttgttatg gttttgccaa tcaaaaattt ttctttttaa gaatcgattg
      241 tattttttcg taaaaaaata ccccctacat tttcgtagga agtattttta gtcaaccata
      301 ccagttgaca gatatcccag aatttccctg taaagaaatc tgatgctttt attatatctt
      361 cttatatact aataaaccct tgcacggcgc cgatagacaa taaaacgacg gaaaatatat
      421 tgccaaggta gcgttaaagc atgaaccaac cgggtgtatg ggaagtaacc aaaaattgct
      481 aatccacaga gaacgtgaat tttataaatt aatggcactg aacgcatcaa ttgccattga
      541 ggattaagaa caaataggct tcttgcccat ggactaattg ttgttcgata gttgtaatcg
      601 ataaatgcac ccgtaatagt acatgctaga cctagtgcaa ttgtaatcag taaagcccag
      661 tcgacaataa tatcattgat atcacttgtc ttataaacac gagaacaagt cattcgtcga
      721 taagtcagaa ttgcaattcc cacaaacgca aggatccctg ctggaattcc catcatcaat
      781 gacccaaaga tgtggtacat atgttcagtg atcccaaaat aagctgtcca acttgctgga
      841 ataaacattc ctaagcaatg accaaagaaa gctaaaataa ttccaatgtg gaaagtaacg
      901 cttccgatca ttagccattt cttttcaaaa agttcgcttg atttggcagt aattgaagga
      961 tgaaaatatt taaatctaac aaatgttcca atgaaaaatg atgccaacat tatatatgga
     1021 taaataaccc ataagaaaat tgaccagcca ttatgcatct tctcgcacct ccattttaat
     1081 acacgaacca attaatgaac gtgtaagcct gattaactga atatagggat tatcactatc
     1141 tgtcactgca ttttttaaaa gggtataagt tccatcttca atcacactta atgctaattg
     1201 gatatcctga cgacgcggat cattagtata atcgccatat gctagaaatt ctaacaatag
     1261 aggcaaataa tcagaaagtt cactggtcgc ttctgatata ccaaacatct catatagcat
     1321 tttcaaccgt gctaaaatgg tccctcgttc acgggaatcg gtcatcttat agtatgacat
     1381 ataaagagta taacgtcggt tcatttcaaa aaggtgagcg tacatctctt gaacttcgat
     1441 tgaagatagt gcggctaatt catcaaaaag gcttaataat tctccccgtg ttgctgttga
     1501 taatgcgtta tctgcaagta ataattgacg aatctctggt gaaaacgttt ctgtatcagg
     1561 atagtcaatc aagcgagaaa gaacggcaaa tgtatccttt aaatctgtca atcgtctaaa
     1621 atcaatcacg ccaaatccct ccatagaaac tatcagcata aatctgatta gttgatttgc
     1681 cagcttctgc cttcttaaac atactcttgt gttggggagc taatgcacag ccttcacatt
     1741 catcatagcc aagactacct tgttcggttt gtgcatcttc catttctgcc ttttggctac
     1801 ttggaataac aaaacggtct tcatatttag caattgccag taaacgataa agtgatgttg
     1861 cccgttcttc tgttaaatca actcgttcca gtttactgct atcaaaatcc cgaccactag
     1921 tcttagcacg catgtatagc cgcatcattg caagtttata taaggctttc ttgatgacag
     1981 gaacgtttcc agcagttaat agacttgcca agtattgaac aggcacccgc atttgatcaa
     2041 ttcctgggaa gatcatttca ggattcttta ttgagtcccg tccttcaaag taactcataa
     2101 ctggtgatag cggcggaata taccaaacca ttggcattgt ccggtattct ggatgaagtg
     2161 ggaaggcaat cttttctttt actgccattt tatagatcgg tgacttttgt gcagcttcaa
     2221 tcatctcttc agaaatgcca tccttgagtg cttgcttgac aacttcagga tcgttgggat
     2281 cgaggaataa gccaagttgt gcttcataca gcttactctc atcagaagtt gatgctgcct
     2341 cttctactcg atcagcatcg tatagaatag caccaatata tcgaattcga ccgacacagg
     2401 tttcggcgca aactgttggt tgaccttctt caattcgcgg ataacaaaaa gtacattttt
     2461 cagccttatg agtcttccag ttaaagtaga ccttcttata tggacatcca gtcatgcaaa
     2521 aacgccatcc ccggcagcgt tcttggtcta ctaaaacaat cccatcttca tctcgtttgt
     2581 acattgcgcc tgatggacaa gaggctacac aaggtgcatt caaacagtgc tcacataatc
     2641 ggggaagata catcataaat gcctgctcaa agttattttt gatatcccct tcaatttttt
     2701 gcatgttagg atcctgttgg acatattcag ttgatcccgc taagtcatca tcccagttag
     2761 gaccagtggt taattccatt ccttcgccag taatttgcga cttaggacga gcaacaggtt
     2821 gatgcttttg ttcagggcca aataacgtct tataatcata ggtccatggt tcgtagtagt
     2881 tatctaactc tggcatatca ttattgtaaa aaatcttgcc aagagcgatt ttatttaatt
     2941 tgcttccagc acgtaatttt aatttacctt ttgaattaag ggtccaccct ccatggtatt
     3001 gatcttcatc ttcccagcgt tttggataac cgacacctgg cttagtttca acattattaa
     3061 accacatgta ttcagcgcct ggacgatttg tccatgtatt cttacaagtt actgaacagg
     3121 tatgacaacc aatacactta tcgagtttaa gaccatgctg atttgtgctt taatcttcac
     3181 tccagttcac cttcttcagt tttcttacat ttgcataaag atcacgttgg tttccagttg
     3241 gtccataata attccaaccg taactcaatt ggcatatcct ccaacatgtg tgttggctta
     3301 acatggattt gcgttggtgc attatgtgat cccccacgat taccggtaat ggtggaaaga
     3361 ggttcataaa tttcattatc ttgggcgtgg tacatgtaca ttgacccctc aggcatccga
     3421 acagaaacaa ccgcccgcgc agtaacaacc ccattacggt tataaacttc gatccagtcg
     3481 ttatctttta ccttaatctt atcggcatct tggggactaa tccaaatagt tggaccaccc
     3541 cggaataatg tcaacatttc aaggttatcg tagtacatcg tatgaatatt ccatttacca
     3601 tgaggagtca tatatttaag tgtaacttca tcttttactg gtggaacatc aacatctcct
     3661 ggggccatta caactggtgg taaggatggt ttataagttg ccatattttc accaaattca
     3721 cggaaaattt catgatcaat gtagaaatgc tgacgacctg taagagtaaa tgtaggaata
     3781 tttcgctcag tcattaatga gaatggtgtg tatcgagccc caccatgttt agcagaagtt
     3841 ccgattggtg ttggatagct tcttgtggtt gagcagtgat ttgcttaaat gacattgaat
     3901 catcagcatg accacggcca atatctgtta aatgttcacc agttcgctct tgcttctttt
     3961 cccaggctcg gtcagcgagt ttaccattgg aagcagttga catccgtaag attgcatcac
     4021 atactttttc atcttcatca agtaacggac agcctgcacc aatgccttcg ctggcagttc
     4081 cattcattcc ttttaaataa tcatattgat catcgacttt atagccatag ttattcacta
     4141 tattaggtcc aagggtaatg aatttatcgt aaatcttggt gtaatcacga gtaaccaatt
     4201 tcaaggaagg cattgttttt cctggaattg gttcagtttc accattcttc caatctttaa
     4261 ttttcccgta cggttgagca atttctccct gggtattatg gccaagtggt gcactcttaa
     4321 gatcgtaaac tgttcctgac atgtatttct ttgccatttc agaaacagtt tttgctaaga
     4381 gcttgaattg ttgccagtca gactttgatt cccacatcgg actgactgct gcattaaatg
     4441 gatgaataaa tgggtgcata tcagttgatg aaaggtcctt cttttcatac caagtagcag
     4501 ctggcaagac aacatcagag tacataggtg ttgaaaccat gcggaagtcc atatcaacaa
     4561 caagatctaa cttaccaatt gctcccttgt cacgccaaac catatcttgg ggcttaactc
     4621 gatcatttgg cttagcaagc aatccgtttt cagcacctaa taagtgtttc ataaagtatt
     4681 cagcaccttt gccagaagat gcaaataagt ttgaacgcca taggaagaag gctttgggtt
     4741 gattttggtt agcatcagga tcttcagcag caaaatgcaa agtccctttc ttcaattcat
     4801 cgacaacttt ctttgaaatt tcatcaatat cagttgtatt gtaatctttt gcaaaagata
     4861 gcggattacg atcaaattgt gggtatgatg gtaaccatcc taaacgaatt gccatttggt
     4921 tataatcagc attatgtaag taagagtgtt tactcttcca aacgggtgac ttttgagctt
     4981 gattatcaat ttcttcataa cgccattgat cagttgcaaa gtaataccaa gtagtacctt
     5041 gcatttgacg ggcaccacct ttttcccagt cattggcaaa agtaatgttt gcccaacctt
     5101 cttgtggacg gagcttttct tgaccaacgt agtgagccca accaccgcca gtcataccaa
     5161 cacaaccgca caacatcagc atattaataa tgtttcgata gttcatatcg gcattgaacc
     5221 agtggttgac tccaccaccc atgattacca tacttcgacc ttcattttcg gccgcgtttt
     5281 gggcaaattc acgagcaatt tgaataactt gctctgcttt tactcccgta cggctttctt
     5341 gccaagcagg agtaaagtaa ctctcagcat ccattgcatc tttagcagca agttcatcat
     5401 taccagtccg attaattccc atttgagcca tcattaagtc gtaaacatta gtaaccaagt
     5461 gttcttgacc atctgtgaat ttgagctttt taactggtaa atgccgttga acaacgctgt
     5521 ttccgtcatt actaaatgca gggaaatcag caataatttg ttcagtttct tcaccttgat
     5581 cattaataga aagtgccggg tcaatcttat tgccattttg gtctaataat tcaagattcc
     5641 atttttcttt agcattatat tcctgaccca tcgttccatt tggaacaaca attttgtggt
     5701 tattttggtc ataaaccact gtcttccatg ctggattaac aatcgtatca tcatcaacta
     5761 agtcactaat ccgaacaaaa cgacctggtg tatagtgagc atcatttgct gtacttggtt
     5821 ccaattcaac catgaatggt aaatcagtaa atcgcttaga ataatcaatg aaacgtttga
     5881 ctgggtgctt ttggtagaat tcatctaaaa ttacataagt cattgcttga gcaacagcag
     5941 aatcactacc tggttctggt gcaagccagt catcagcgaa ttttacattt tcagcataat
     6001 cagggctaac tgctacaatc tttgttcctt tgtacctaac ttctgtcatg aagtgtgcat
     6061 ctggtgtccg agttaatgga acgtttgatc cccacataat aatataggaa ctgttatacc
     6121 attctgcaga ttctggaaca tcagtttgtt caccccaaac ttggggagat gcaggcggta
     6181 gatcagcata ccaatcgtag aaactcattt gttccccacc cattaaggcg atgaatcggg
     6241 ctccggcact gaaactcatc attgacattg caggaattgg ggtaaaacca ccaatacggt
     6301 cgggcccata tttcttaatt gtgtataagc aagcagctga aatcatttct aatgcttcat
     6361 aacgatgaac acgaattaag ccaccgtgtc ctcggacctt tttatacttt ttagactttt
     6421 ctggatcttc gacaatactt gcccacgcat ctaagggatt ttcatgttct ttcttggcag
     6481 cagtccaaag ctcccataat ttaccacgaa tatatgggta cttaattcga acgggactat
     6541 attcatacca agagaaacta gctccccgtg gacatccccg tggttcatat cctggaatat
     6601 taggtccgca tgatggataa tctgtagctt gatgttccca agtaataatt ccttgcttga
     6661 cataaacatt ccaagaacat gagcctgtac aattgactcc atgagttgtt cggacaactt
     6721 tgtcatgcgc ccatcgctga cgataaagct tttcccaacg acgactattt tcttcaagtt
     6781 gtgtaaaggt tccattaaac ttatcaacct tgttaaagaa ccgtgacttc atcgttgatt
     6841 gacctccttt attgaatggc ttaccaatat taaaaataaa gtaagtcttt tccctaatgt
     6901 aaagattagc accataactg ctatactacg actagggaaa tacctatatt ttcgaactaa
     6961 atgaggtgtt aatatccatg aatcgttacg atcgtcaaga aagggtacat caaattggtg
     7021 tcgttggtca gcaaaaaatt agccatgcaa ctattatgat tgtcggtgta ggagcattgg
     7081 gaagttatac agctgagcaa cttgtccgtg ctggagttaa aagacttgtc ttaattgatc
     7141 ctgacactgt tgatgtaact aatcttcaac gtcaatcgct tttcaccgaa gcagatgcta
     7201 accaacaacg gcttaaggtc gaagcagcta aagaacattt acataaaatt aattcagcat
     7261 gtcaaattat tgcgatccca gcgccaatta ctgctgatct tattgacgaa tatcagttta
     7321 ccctttgttt agactgtctt gataattatc aagcacgcga tctattaaac aaattggcaa
     7381 tcatcaaaaa ttttgattat ctgtttgcca gctgtgcagg aacctatggg aacgtaatgg
     7441 cgatttcgcc acaaaattat ccttgcttga actgtctttt tcctaatatc aatgaattaa
     7501 aacaaaacga ttgtgattta attggggtta atactgcttt aattcctatt gtagcgggac
     7561 tacaggtatc tttagcgctt cattatctag ttgataaaac acaggttaat tttaatgaat
     7621 tgatcactgt tgacaattgg tcaatgcaat ttagtaaatt tatcattaat aaaaatagcc
     7681 attgtccggc ttgcactaat cctagcagca tttctttgga agaagaatca gcaccagaat
     7741 tacatatgtt atgtggggaa aatgcatatt atacagtcaa agagaaacct attaattttg
     7801 gcagacttaa agaatttttg gctaaaaaag agctcttaat taacgcaaat cgattgtttc
     7861 ttcattttaa atgggaaaat cgtccagtaa gtatattcaa gaatggtaag attgttatgt
     7921 atgacttacc tacttcggcg attgcccaga aacagtttga gtcattaaat actttaatga
     7981 aagaagacct attatgaaaa aaatcgcaat tttaacggtt agcgatagtc gaacattaga
     8041 tagcgatact tctggaaaat taattgctat gaagatggct aatgcgggcc tatcagtagt
     8101 tgatcgggta atcgttaatg atgatattgt caatattcaa actgcctacc ttcaactaga
     8161 acaacaagcc attgatatca tcattactaa tggtggaaca ggagttgctc agcgtgatgt
     8221 tactattccg gctatccgtc cactcctcaa acgcctaatt cctggttttg gggaagcgtt
     8281 tcgccagata tcttttgatg aaattggtac tcgggccctt gcatcacaag ccctagccgg
     8341 atttaattac cgcaaccagc tcacctattg tttaccaggt tcccagaatg cctgtcaaac
     8401 ggctctaaac aaactaattt tgccagaata tgaacattta ttatttgaaa gcagttccca
     8461 acgaaaggaa gttcaccacc atgctcacta gaagaacacc aatctctgtt gccgaggcac
     8521 agaaaaagat taacgaaatc cccctgaaaa caactacaga aacaattccc ctatcagaag
     8581 ctaaccatcg tattttagct gaggatgtcc atgctcatta tgactatcct cattttcgcc
     8641 gagcaggaat ggatgggtat gcaattttag ccagcgatga tcatgacttc ccccgcgagt
     8701 ttaatgtccg aggagagatt caagctggag caacttggga tcaaccatta cagccagggg
     8761 atgcagttcg gataatgact ggtgcatatg tcccttctga tgcggggaaa gtaattcgaa
     8821 ttgaaaaaac tcgtcctgct gaagataaaa ataaggttca aattattaca actgagagta
     8881 aaactaacat tacagaaact ggtactgatg taaaaagcgg tgatatcgtt ttagcaaaag
     8941 atcaggaaat aaatcccggt ggcctagcag tcttaacggc ttttggtgtt caagaagtaa
     9001 cagtttataa aaaaccacgg attgcaatta tcgccactgg aactgaatta ttaggcccta
     9061 atgagacaat tgaaccggga aagatcttta atagtaatgg aattatgtta aaaaatctgg
     9121 tagaagaaac tggtgggatt gttgattttg aaacccaatt accagatgat gctaatctta
     9181 tcaagcagac tcttgaagaa caaatagcaa ctcatgaaat tgtaattact gatggtggcg
     9241 tttctgtcgg tgattttgat ttcattggag atgaagcacg taaagctgat gaattgctgt
     9301 ttaataagat taagcaacga ccaggaagcg ttacgactgc ctttgttcaa aataatacgt
     9361 tagtaatggc tctttctgga aatccaggcg cttgttttac tggcttttat ctctacatgg
     9421 aaccgctgat tcgacgttat caacaccaag caagccgaat taagcgagta cgggcaatat
     9481 tagcagcccc atataataaa actaacggct ttgatcgtta ccttcgttgt acttatgaat
     9541 tcaaagatga tcaattttat gtttatccaa atggaatcaa ccgatctggc tcattagcta
     9601 acctccagac gacgacctgt ttggcactga ttccgcatag tacaactcca atgaaggttg
     9661 gaacggagac tgacgcatgg ctattaccct tcaaataatt ggtcataaga aaagcgggaa
     9721 gactcttatc acgacggctt taattgaaag gctttcaaaa gaaggatatc gagtagctgc
     9781 tcttaaacat gatgcccata atgctgcaat ggatgtgcca actactgaca gtgctagaat
     9841 gagtaacgct ggagcaaacc aagttatctt gcaatctcca actgaatttt tctttcatca
     9901 aaaaagtaat gttccaactt taacggaaat ggttgagttg ttaagtgacg acaatgattt
     9961 tgtcttgatt gaaggccata aggaagccac tcaatatccg caaattttat tattaaagcc
    10021 tggcgaagat cctactaata ttgctcctac tacgccgctt aaaaccggta gtatttttag
    10081 tgggacaaat gctgacttac tagggaaaaa tacaattgta aactggtgct ataactactt
    10141 aaaacaaata aaggagaata cttgatgatt ggattagtat acgcgggcgg caaatctatt
    10201 cgctttggta aagacaaggc cacttatcat gttccaagat taccagctac caatgtacag
    10261 ctagcagttg agaaactaat gcccctttgt cagcagatca ttgtttgtgc taatgaaaca
    10321 aatcgtgcac atataataga attagttggt caggtaccgg ctgtgcagat tatctgtgat
    10381 attcctcctt atgatcatca tggtcccctt tcagcaatta ttgcttgtac tagtcaattt
    10441 tctgttgttc aagactattt aactttggct gttgattatc catatatcac aaaagatgta
    10501 cttgccattc ttgctcgtac atccaactct tatattgtaa caagtcagca tagtcattat
    10561 tcattagctc atttttcaat tagcaatgaa caagttacta catgggttga taataatagt
    10621 gactggcgat tacgtagttt catcactaat aaatgcgggt gtcatcccct tgcatatcgc
    10681 tcaagtgccg aattttcaaa tttaaactat cgtgaggtcg atttaaatga aaagtaaaga
    10741 ttcaatgaca aatcctgatt ttcaaaaact catttccctt gtcttaaatg acttaacaat
    10801 cagacgaaca atgttagaaa atcgggaaca agaagtaaac caacaaatga gttcactgga
    10861 aaaagatgct aaattggagc aattggatga ccaaattcaa caaattcaag ctgattttga
    10921 tcattaccgt gaattccaag atccggaatt tgattttagt gcaaccaagt atttccaggg
    10981 accatcgatg gggttaccac gacatcctta aaagctagat ggcagggcta aagaagcaga
    11041 gcttttctta gccctgcctt ttaagttgtc tatcgttgct tctagccaaa gaaagcgtta
    11101 atatataaaa taggaatatt atgatagcaa ttggggaatt ttattgggga ggaagcagat
    11161 cgtgcttgaa acagctaatt ggatacaaaa atattttaat caatcaccag atgcaatctt
    11221 cttatttaaa atgatgatct tttagttaat aatgagccgg cacaacggtt agttactatg
    11281 cttaatttag atgtcaatta cctattacaa attggaaaga acgcttggtc acaactggaa
    11341 aatgatgact gtgcgtcatg tctgattaaa aagcggttaa aaggagctgc agttccgata
    11401 acatttcatt ccaatgctac tcatcctttt cacttttcaa tggtttatcg tcctcttgat
    11461 gataaagaaa atgtctttgc cctaactctt gaaaatagtg agcaacagca gcgcctttct
    11521 caagttgagg agcaacgaat tctcaatcaa tatgtcaatg aagcgcatga aaaggaacgg
    11581 caaaaaatct cacaagatct tcacgatagt gttgcgcagg gaatctacgc ggcaataatg
    11641 ggcattcaaa gattagcaac ggttcaaaat ccaagaaaca ctgagcagtt tcaatcaatg
    11701 agtgctgcaa tcgaaaagca gttacaaacg acccttaaag agattaaaga gctcgcactc
    11761 gatatccgcc cctcggtgct cgataatttt ggcttaattc cagcaatcaa agctttggca
    11821 aaacggcttc aaaatagtac aggaatcacg attaatgtta tagcccttac ctctgccgaa
    11881 aaactgcaaa aaaatatcca aaacgttctt taccgaatta cacaagaggc aattaataac
    11941 gcaattaagc atgctcattc aacagaaata actattattg ttaccaacca taatagttac
    12001 cttcagttag agatccttga taatggtatc ggctttgatc ttgaacagca tagcagattt
    12061 aatgggcatt cacttggatt aatgaatatg aatgaacgcg ttaaggcata taatggggcc
    12121 tttacaatta catcaaaaat taataaggga acgacagtca aggtgaagtt tccctataat
    12181 aatttaaata aggatacggt gagaacaaat gtataacgtt ttagttgcag acgaccacgc
    12241 aatcgttcgt tcaggaattt catatttagt cgatcttcaa ccgaatttta cggtggttga
    12301 tgggacagcg agtggaacag atacatatat tcgagttgaa ccaggattct cacctgtctt
    12361 tcgctactca taccggcatt ctcacttcta agcgctccac cagtcctcac ggtctgactt
    12421 cgccgccctt agaacgctct cctatcacgt gcacatagtg cacatccaca gtttcggtaa
    12481 tatgcttagc cccggtacat tttcggcgca ggatcactcg actagtgagc tattacgcac
    12541 tctttaaatg gtggctgctt ctaagccaac atcctagttg tctatgcaac tccacatcct
    12601 tttccactta gcatatattt agggacctta actggtgatc tgggctgttc ccctttcgac
    12661 ggtggatctt atcactcatc gtctgactcc tgagtataaa tcgatggcat tcggagttta
    12721 tctgaagttg gtaacccatg acgggcccct tgtccaaaca gtagctctac ctccacgatt
    12781 ctttacctca aggctccccc taaagagatt tcggagagaa ccagctatct ccaagttcgt
    12841 ttggaatttc accgctaccc acacctcatc ccagccattt tcaactgaca cgggttcggt
    12901 cctccagtgc gctttaccgc accttcaacc tggacatggg taggtcacct ggtttcgggt
    12961 ctacaactac atacttctta cgcccattta agactcgctt tcgctac
//
