LOCUS       c00251_gnlPro..        12053 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LCILEPJP_251.
ACCESSION   c00251_gnlPro..
VERSION     c00251_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-03 18:29:48
            Original ID  :: gnl|Prokka|LCILEPJP_251
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12053
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12053
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1919:7815]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1920..7815
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..12053
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12053
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             2..793
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SDH_alpha"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg251_1"
                     /sec_met_domain="SDH_alpha (E-value: 4.6e-63, bitscore:
                     202.7, seeds: 645, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="IASCIEEEDVLDLTLRKVYDFAMTTPLDDIRFILETARLNKAAAE
                     RSFEGDYGHGLGKILRGTYEHKVMGDSVFSHILSYTSGACDARMAGAMIPVMSNSGSGN
                     QGISATLPVLIYAEENGKSEEELIRALMLSHLTVIYIKQSLGRLSALCGCVVAATGSSC
                     GITWLMGGTYEQVAYAVQNMIANLTGMICDGAKPSCALKVTTGVSTAVLSAIMAMENRC
                     VTSVEGIIDEDVDQSIRNLTKIGSKGMNETDKLVLEIMTSK"
     CDS             complement(857..1429)
                     /locus_tag="ctg251_2"
                     /transl_table=11
                     /translation="METVENKYITVAYKLYSIENGEKDFEEEAPVEHPFQFISGLGMTL
                     EPFEAQIKDLQIGDKFDFTIPASEAYGEYDDDHVIDLPKEIFMIEGEFDSDRVVEGAVI
                     PLMTSEGQRINGSVVEVKEDVVVMDMNHPLAGCDLNFTGEVVESRPATNEELAEVARMM
                     GGGCGSCGCGDCGDGCGDHECGGGCCH"
     CDS             1920..3395
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg251_3"
                     /sec_met_domain="ILVD_EDD (E-value: 1.4e-85, bitscore:
                     277.1, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKHQLRSSFSTQGRRMAGARALWTANGMKKEQMGKPIIAIVNSFT
                     QFVPGHVHLHEIGQFVKEEIEKLGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADS
                     VEYMVNAHKADAMVCISNCDKITPGMLMAAMRLNIPTVFVSGGPMEAGEWNGQHLDLID
                     AMIKSADESVGDKEVAQIEQHACPTCGCCSGMFTANSMNCLNEAIGLALPGNGTIVATH
                     ENRKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
                     XXXAPNTQKYHVQDVNRAGGIIAIMDELAKGGLVDTNVRRVDGMTLAEAIDRYSITSSN
                     VCKEAIKKYSSAAAGKFNLVLGSQNASYKELDTDRATGCIRDLEHAYSKDGGLAVLKGN
                     IAQDGCVVKTAGVDESIWKFTGPAKVFDSQDAACDGILGGKVVSGDVVVITHEGPKGGP
                     GMQEMLYPTSYIKSRHLGKECALITDGRFNYRN"
     CDS             4219..5379
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg251_4"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3.8e-48, bitscore:
                     152.6, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLLRWTMSVAIFPFPKXXXXXXXXXXXXXXXXXXGQGVELGEAQ
                     QELRAFIEKAGMPAGCTLLGLSALPTNHPLNKGMLGMHGNLGPNINTNKCDVLIAVGMR
                     FDDRVTGKLETYAKQAKIIHFDIDPAEIDKNVKTDVAVLGDCKETLAAVTQLLEPANHQ
                     EWIDSFRQYEEVEEEKVIRPELHPAGKALSMGEVVRAVSEATHNEAILVTDVGQNQMMS
                     ARYFKYSKERSIVTSGGLGTMGFGLPAAIGATFGRPDRTVCVFMGDGGLQMNLQELGTI
                     MEQKAPVKMILLNNNFLGNVRQWQAMFFNRRYSFTPMMNPDYMKIASAYDIPARRVMTR
                     EELAKAIDEMIATDGPFLLEACVEEEGNVMPMTPPGGSVNQMLLEC"
     CDS             5412..5972
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg251_5"
                     /sec_met_domain="ALS_ss_C (E-value: 6.1e-20, bitscore:
                     60.8, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKKLYTIIVHSENFAGLLNQVTAVFTRRQINIESLNVSASSIKG
                     VHKYTITAWTDKDTIEKVTKQITKKIDVLQAHYFTDDEIYQHEIALYKITTPTLEEKPE
                     VSKVIRKYNARIVEVNAVFAIVEKNGMSEEITNLYEELRQLDCVLQFVRSGRVAITTSC
                     FERVNEYLADREAKYRQSKHQEL"
     CDS             5969..6721
                     /locus_tag="ctg251_6"
                     /transl_table=11
                     /translation="MMSENNKIGTYKFVAEPFHVDFTGRLTMGVLGNHLLNCAGFHASD
                     RGFGIATLNEDNYTWVLSRLAVELDEMPYQYEDFSIQTWVENVYRLFTDRNFAIIDKEG
                     KKIGYARSVWAMISMNTRKPADLLALHSGSIVDYVCDEPCPIEKPSRIKVASKEPVATL
                     VAKYSDIDINGHVNSIRYIEHILDLFPIEMYKEKRIRRFEMAYVAESYYGDELTLFMDD
                     AGEGVYDVEVKKNGSEVVCRSKVIFTEK"
     CDS             6772..7815
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg251_7"
                     /sec_met_domain="IlvN (E-value: 3.9e-47, bitscore: 149.3,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 3.5e-41, bitscore: 130.3,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLNFGGVIENVMTREEFPLEKAREILKDETIAVIGYGVQGPGQ
                     ACNLRDNGFNVIVGQRPGKTYEKAVADGWVPGETLFGIEEACQKGTIVMCLLSDAAVMS
                     VWPTIKPYLTPGKALYFSHGFAITWNDRTGVVPPKDIDVIMVAPKGSGTSLRTMFLEGR
                     GLNSSYAVYQDATGKAFDKTIALGIGIGSGYLFETTFIREATSDLTGERGSLMGAIQGL
                     LLAQYEVLRENGHTPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMT
                     PFHDAIKPVVQKLYASVKSGNEAQISIDSNSKPDYREKLNAELKALRESEMWQTAVTVR
                     KLRPENN"
     CDS             complement(7877..9790)
                     /locus_tag="ctg251_8"
                     /transl_table=11
                     /translation="MITFATMKEQDSNSPIIHLQQQQLLLRMEYEYEKEEFKRQTENMG
                     IARKVKRGLCWYPATPGRSYYNSLNQLVIEITHTENTDIEHNFEFGRPVCFFRQSADGK
                     ITYMNFTATVSYADETRMVAIMPGAGAVMEVQETDNLGVQLYFDETSYRTMFEALEDTL
                     RSKGNRLAELRDILLGASKAGFRELYPVRFPWLNSTQETAVNKVLCARDVAIVHGPPGT
                     GKTTTLVEAIYETLHREPQVLVCAQSNTAVDWISEKLVDRGVNVLRIGNPTRVNDKMLS
                     FTYERRFENHPLYPELWSIRKNLRELGSRARRGSYDEREGVRSRMSRLRDRATALEIQI
                     NSELFDGAHVIASTLVSSNHRLLNGRRFGTLFIDEAAQALEAACWIAIRKADRVVLAGD
                     HCQLPPTIKCYEAARGGLERTLMEKVVSNKPAVVSLLKVQYRMHEEIMKFPSQWFYNGE
                     LEAAPEVRYRGILDWDTPIHWIDTSEMDFKEEFVGETFGRINKAEADLLLSELKIYINR
                     ISGNRILEEKIDFGIISPYKAQVQYLRNKIKADASLKPYRSLFTVNTVDGFQGQERDVI
                     FISLVRANEEGQIGFLNDLRRMNVAITRARMKLVIMGEAETLKHHGFYRKLLEFIQNIG
                     NQ"
     CDS             9905..11338
                     /locus_tag="ctg251_9"
                     /transl_table=11
                     /translation="MVYDLTMLKAFYAAYSEKIERVRNVLQRPMTLAEKILYAHLYDGD
                     KVKNYRRGEDYVNFRPDRVAMQDATAQMALLQFMNAGREQVAVPSTVHCDHLIQAYKGA
                     KEDIATATKTNEEVYNFLRDVSSRYGIGFWQPGAGIIHQVVLENYAFPGGMMVGTDSHT
                     PNAGGLGMVAIGVGGADAVDVMTGMEWELKMPRLIGVHLKGKLSGWVAPKDVILKLAGI
                     LTVKGGTNAIIEYFGPGTASLSATGKATICNMGAEVGATTSLFPYDERMGTYLKATGRE
                     EVAKMAASVAADLRADDEVLANPEKYYDRIIEIDLSLLEPYINGPFTPDAATPISKFAE
                     VVITNNYPRRMEVGLIGSCTNSSYQDLSRAASLARQVKEKNLKVASPLIVNPGSEQIRA
                     TAERDGMIAAFEDIGATIMANACGPCIGQWKRHTDDPXXXXXXXXXXXXXXXXXXXXXX
                     XXXXXXXXXXGCETVRTGR"
     CDS             11313..12053
                     /locus_tag="ctg251_10"
                     /transl_table=11
                     /translation="VKLSEPVGEELPAHGFIGGKEGYIAPGKGQTKITVNPHSQRLQLL
                     TPFPAWDGMDLLDMPLLIKVQGKCTTDHISMAGPWLRFRGHLENISDNMLMGAVNAFNG
                     ETNSVWNRSTNTYGTVSGTAKLYKSEGIPSIVVAEENYGEGSSREHAAMEPRFLNVRVI
                     LAKSFARIHETNLKKQGMLALTFTDKADYDKIRERDLISVMGLKDFAPGRTLKVVLHHE
                     DGSKESFEVQHTYNEQQIAWFRAGS"
ORIGIN
        1 aattgcctct tgtatcgaag aggaggatgt attggacttg actttacgca aagtgtatga
       61 cttcgccatg acaaccccat tagacgacat ccgttttatc cttgaaacgg cccgtctgaa
      121 taaggcggct gcagaacgtt cttttgaggg tgattacgga catggtctgg gaaaaatcct
      181 tcgcggtact tatgagcaca aggttatggg ggatagtgtt ttttcccata ttctttctta
      241 tacttccggt gcctgcgatg cccgtatggc aggagctatg attccggtca tgagtaattc
      301 aggaagcggt aatcaaggta tatccgctac gttgccggtt ttgatttatg ccgaagaaaa
      361 cggaaaatcg gaggaagaat tgatacgcgc cttgatgttg agccatttga cggtaattta
      421 tatcaagcag agtttgggac gcttatctgc cttatgcggt tgtgtggttg ctgctacggg
      481 ttccagttgc ggtataactt ggctaatggg aggaacttat gaacaggtgg catatgctgt
      541 acagaacatg attgccaatc ttaccggaat gatttgtgat ggtgccaagc ccagttgtgc
      601 attgaaagta accaccggag tttcaaccgc agtgctttca gccatcatgg ccatggaaaa
      661 ccgttgtgtg acttccgtag aaggtattat tgatgaggat gtggatcaaa gtatccgtaa
      721 tctgacaaaa atcggttcta aaggaatgaa tgaaactgat aaattggtat tggagataat
      781 gacaagtaaa taatatagaa tttgaaaatt aaagaattaa aaattaaaga attaccatgc
      841 ggcatgctta atactgttag tggcagcatc cgcctccaca ttcatggtcg ccgcatccgt
      901 cgccacagtc accacaaccg cagctaccac aaccgccacc catcatacgg gcaacttcag
      961 caagctcttc gttcgtggcc gggcggcttt ccaccacttc tccggtaaag ttcaaatcac
     1021 aacctgcgag tggatgattc atgtccatta caactacgtc ttcctttact tctactacac
     1081 ttccattgat gcgttgacct tcagaagtca tcaaggggat gacagcgcct tccactacac
     1141 ggtcgctgtc gaattctcct tctatcatga agatttcttt ggggaggtca atgacatggt
     1201 cgtcgtcata ttcaccataa gcttctgatg ccggaatggt aaagtcgaat ttatcgccta
     1261 tttgcaagtc ttttatctgg gcttcaaaag gttcgagtgt cattcccaga cctgagataa
     1321 actgaaaagg atgctctacg ggtgcttctt cttcgaaatc tttttctccg ttttcgattg
     1381 agtacagctt atatgctacg gtgatgtact tgttttctac tgtttccatt aattttctat
     1441 ctttatttaa ttagtaaata ctgttttttt gagtatttga agagacaaag atacgaatta
     1501 tttgtttcgg gatgtagaga gcctttggta attttcagat tattaaatgg tttcaatgat
     1561 tggcaataca tttacattgg ctgtctgaat ggttctattt agaactgtta agtgataaaa
     1621 taggatttta gggcgatttt ttcttacgat tattcatatt tatcttattt ttttcttcaa
     1681 tttgtttgga gattataaaa aagcccttac ctttgcagca cgtttgaaac aaaaaagaag
     1741 aattaagtta tgaatttaca tacatctatt aacctggcag tcctgcatat tattcgcgtc
     1801 gtggtggtgg catcaagagc gtgagaaagg ttatgtatgt attcgtacgt tagaagataa
     1861 tttattaagc ctttctcact atagtgggag aggctttttc attaaaagga gatttgaaaa
     1921 tgaagcatca gttacgcagc tcgttcagca cacaaggtcg ccgcatggcg ggagcccgtg
     1981 cattgtggac ggcgaatggt atgaagaagg aacagatggg taagcccatt atcgctatag
     2041 tcaattcatt tacacaattc gtccccggac atgtacacct gcacgaaata ggccagtttg
     2101 taaaggaaga gattgaaaag ctggggtgtt ttgctgcgga gttcaatacg attgccattg
     2161 acgacggtat cgctatggga cacgacggta tgctttattc cctgccttca agagatatca
     2221 ttgccgatag tgtggagtat atggtaaatg cccataaggc agatgctatg gtttgcatca
     2281 gtaactgtga caagattact ccggggatgc tgatggcagc tatgaggctg aatataccga
     2341 ctgtgtttgt ttcaggcggt ccgatggaag ccggggaatg gaacggacaa catttggatt
     2401 tgattgatgc tatgattaaa tctgctgatg aaagtgtggg cgataaagag gtggcacaga
     2461 ttgagcaaca tgcctgcccc acttgcggat gctgctcagg catgtttacc gctaattcca
     2521 tgaattgcct gaatgaagcg attggattgg cactgcccgg taacggcacg attgtagcca
     2581 ctcacgaaaa tcgcaagann nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2641 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2701 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2761 nnnnnnnnnn ngctcccaat acccaaaagt atcatgtaca agacgttaac cgtgccggtg
     2821 gcatcattgc catcatggat gagcttgcca agggcggatt ggtcgatacg aatgtccgcc
     2881 gtgtggatgg aatgacgttg gcagaggcaa tcgaccggta tagtattacc agctctaatg
     2941 tatgtaaaga ggcaatcaag aaatactcca gtgcggcagc cggaaagttc aatctggtac
     3001 tcggctcaca aaatgcgtct tataaggaac tcgatacgga ccgtgcgact ggttgtatcc
     3061 gtgatttgga acatgcatac agcaaggatg gcggtctggc ggttttgaag ggaaatatag
     3121 ctcaggacgg ttgcgttgtc aagactgccg gtgtagacga gagtatctgg aaatttacgg
     3181 ggccagcgaa agtcttcgac tcacaagatg cggcttgtga cggtattctg ggtggaaagg
     3241 tggtcagtgg agacgtcgtc gtcatcactc acgaagggcc gaaaggtgga ccgggtatgc
     3301 aagagatgct ttatcctact tcttatatca aatcccgcca tctgggtaag gagtgtgcat
     3361 tgattaccga cgggcgtttt aattatcgaa attgatatac cgaaccgttc tatcaatgtg
     3421 aagttgacgg atgaagagct tgcagcacgc cctatgactc cggtaacccg caaccgtgaa
     3481 gtctccaaag cattgaaagc atatgccagt atggtgagtt ccgctgacaa aggggctgtg
     3541 aggctgattg attaaaagcc cccctttccg aaagcgaggg gaggagagaa tgaaacaaat
     3601 ttttcaagct actattgagc ttttaaatat aatgaataga taaagtatgg ctgataataa
     3661 taaaaagagt aacttttcct ccctctccca aggagagggt cggggtgagg ctctaataac
     3721 aggcgcagaa gcattgatgc gctctctgga gcatcaggga gtaaagacta ttttcggtta
     3781 tccgggaggg agcatcatgc cggtattcga tgccttatac gaccannnnn nnnnnnnnnn
     3841 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnng
     3901 gcgaggttgg cgtttgtctg gttaccagtg gaccgggtgc taccaatact atcacgggca
     3961 ttgcagatgc catgattgac agtacgccta tcgttgtcat tgccggccag gtagggacga
     4021 acttcttggg tacggatgca tttcaggaag tggacttggt aggcattact cagcctatca
     4081 cgaaatggag ttaccagatt cgtcgtgcag aagatgtggc ctgggcagtg gcacgtgctt
     4141 tctatgtggc aaagagcgga cgtccgggac cggtcgtgct ggattttgct aaaaacgccc
     4201 aagtggagaa aacagaatat gcgcctacta aggtggacta tgtccgtagc tatcttcccg
     4261 ttcccgaaat gnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4321 nnnggacaag gcgtggagct gggagaagcc cagcaagagc ttcgtgcttt cattgagaaa
     4381 gccggaatgc ctgccggatg cactttattg ggactttccg cattacctac gaaccatccg
     4441 ttgaacaaag gaatgcttgg tatgcacggt aacctggggc ccaatatcaa taccaataaa
     4501 tgtgatgtcc ttatcgccgt aggcatgcgc tttgatgacc gtgtgacggg taaattggaa
     4561 acatatgcca agcaggcgaa gattatccac tttgatattg accctgccga aatagataag
     4621 aatgtaaaga ctgatgttgc tgtcctggga gattgcaaag agacactggc tgccgttacc
     4681 caattgctgg aacccgccaa ccatcaggaa tggattgaca gtttccggca atacgaggaa
     4741 gtggaagagg aaaaggtaat ccgtccggaa ttacatccgg caggaaaagc gctaagcatg
     4801 ggtgaggtgg tgcgtgctgt gagtgaggct acccataacg aggcgatatt ggtgactgat
     4861 gtcggccaga atcagatgat gtccgcccgt tatttcaaat acagcaagga acgtagcatt
     4921 gttacttccg gtggcctggg tactatgggc ttcggccttc cggcagctat cggtgccact
     4981 tttggacgtc cggaccgcac ggtatgcgta ttcatgggag acggcggctt gcagatgaac
     5041 ctgcaggaac tgggtaccat catggaacaa aaggctccgg tgaagatgat tctgttgaac
     5101 aataacttct tgggcaatgt tcgtcaatgg caggcgatgt tcttcaatcg tcgttattcg
     5161 tttactccga tgatgaatcc ggattatatg aagattgctt cggcatatga tattcctgca
     5221 cgcagggtaa tgacccgcga ggagctggca aaagcgattg acgagatgat agcgactgac
     5281 ggaccgttcc tgctcgaagc ttgtgtggag gaagaaggaa atgtaatgcc gatgacacct
     5341 ccgggcggtt cggtcaatca gatgttgttg gaatgctgaa gtcatgcgaa attaaagaat
     5401 ttactctatc tatggataaa aaactatata caatcattgt tcattcggaa aactttgccg
     5461 gtttgctgaa tcaggtgacg gctgtgttta cccgccggca gataaacatc gagagtttga
     5521 atgtatcggc ctcctccatc aagggggtac ataaatatac cattaccgct tggacggaca
     5581 aggataccat tgaaaaggtg accaagcaga ttaccaagaa aatagatgtg ctgcaagccc
     5641 attatttcac ggatgatgaa atctatcagc acgagattgc cctttataaa ataacgaccc
     5701 ctacgctgga agaaaaaccg gaggtgtcca aagtaatccg taagtacaat gcccgtattg
     5761 tggaggtgaa tgctgtattt gccattgttg agaagaatgg catgagtgag gaaataacca
     5821 atctttatga ggagttgcgc cagttggatt gcgtacttca gttcgtccgt tcgggtcgcg
     5881 tagccattac gaccagctgc tttgagcgtg tcaatgaata tctggcggac cgtgaagcaa
     5941 aatatcgtca aagtaaacac caggaattat gatgagcgaa aacaataaga taggtaccta
     6001 caagtttgtt gccgaaccgt ttcatgtcga ctttaccgga cggctgacaa tgggagtatt
     6061 gggcaaccat ttgttgaatt gtgcgggttt ccatgccagc gaccgcggtt ttggcatcgc
     6121 gactctaaac gaggacaatt atacttgggt attgtcccgt ctggctgtcg aactggatga
     6181 aatgccttat cagtacgaag atttctccat tcagacttgg gtggagaatg tctatcgcct
     6241 ttttacagac cgtaatttcg ctatcatcga taaggagggc aagaagattg ggtatgcacg
     6301 ttccgtttgg gcgatgatta gcatgaatac ccgtaagccg gcagatttgc tggctcttca
     6361 tagtggcagc attgtagatt atgtttgtga tgaaccttgc ccgatagaaa aaccttcgcg
     6421 gataaaggtg gcctcaaagg aaccggttgc tactttggta gccaaataca gtgatattga
     6481 cattaacggg catgtgaaca gcatccgtta catcgagcat atccttgatt tgttcccgat
     6541 agagatgtat aaggagaagc gcatccgtcg ttttgagatg gcatatgtag ccgaaagcta
     6601 ttatggggat gagttgactt tgttcatgga tgatgccggt gagggcgttt acgatgtgga
     6661 ggtgaaaaag aatggcagcg aagtggtctg tcgctctaaa gtgatattta cagagaaata
     6721 aataaattta tcaacgttgg cgtaagccac aaataaaaat taaaacaaaa aatggcacaa
     6781 ttgaattttg gcggtgttat tgagaatgta atgacccgcg aagaatttcc tttggaaaaa
     6841 gcacgtgaga ttttgaaaga tgaaacaatt gcagtaatcg gttatggcgt acaaggcccg
     6901 ggccaggctt gcaacttgcg tgataacggt ttcaatgtga ttgtaggaca acgtccgggt
     6961 aagacatacg aaaaggctgt ggctgacgga tgggtaccgg gtgagacttt gttcggcatc
     7021 gaagaggctt gtcagaaagg tactatcgtc atgtgtctgt tgtctgacgc agctgtaatg
     7081 tctgtatggc cgactatcaa accttatttg actcccggaa aggctcttta cttctctcat
     7141 ggttttgcta ttacctggaa cgaccgtacc ggcgtggttc ctcctaaaga tattgatgtt
     7201 attatggttg ctcccaaagg ttccggtact tcacttcgta ccatgttcct cgaagggcgt
     7261 ggcttgaact catcatatgc cgtctatcag gatgctacgg gtaaggcttt tgacaagacg
     7321 attgcactgg gtatcggtat tggttcggga tatttgttcg agacaacttt catccgcgaa
     7381 gccacttccg acttgaccgg tgaacgcggt tcattgatgg gtgctatcca gggattgctg
     7441 ttggctcagt atgaagtatt gcgcgaaaac ggccatactc cttctgaagc attcaatgaa
     7501 acagtggaag agttgactca atctttgatg ccattgtttg ccaagaacgg tatggactgg
     7561 atgtatgcca actgttctac tacggcacag cgtggtgcgc tggattggat gaccccgttt
     7621 catgatgcca tcaagccggt tgtacagaaa ttgtatgcaa gtgtgaagtc gggcaacgaa
     7681 gctcagattt ctatcgacag taactccaaa cccgattatc gtgagaagct gaatgcagaa
     7741 ttgaaagcct tgcgtgaaag cgaaatgtgg cagacagctg ttacagttcg taaacttcgt
     7801 ccggaaaaca attaatcagc tttatataaa taggtgaaat accctcttcg gtgttaccgg
     7861 agggggtatt tctttattat tgattcccta tattttgaat aaactccagt agcttccggt
     7921 aaaaaccgtg atgtttcagc gtctctgcct ctcccattat caccagcttc atacgtgccc
     7981 gggtgatggc tacattcatt ctccttaaat cattcaggaa tcctatctgc ccttcttcgt
     8041 tggcacggac aaggctgatg aagataacat cgcgctcttg cccttggaag ccatccaccg
     8101 tatttacagt gaacaagctg cgataaggct tgagtgaagc gtctgccttt atcttgttgc
     8161 ggagatattg cacttgtgcc ttgtaagggg agatgatgcc gaagtctatt ttttcttcca
     8221 gaatgcggtt gccactgata cggttgatgt agattttcag ttctgatagg agcaggtccg
     8281 cttccgcctt attaatgcgc ccgaaagtct ctcccacaaa ttcttctttg aaatccattt
     8341 cggaggtgtc aatccagtgg atgggggtat cccagtccag gatgccccgg taacgcactt
     8401 cgggagcggc ttccaactcg ccattataaa accattggga aggaaatttc atgatttcct
     8461 cgtgcatgcg gtattgtact ttcagcaaag agacaacggc aggtttgttg gacaccactt
     8521 tctccatcaa tgttcgttcc agacctccac gggcggcttc gtagcatttt atggtgggtg
     8581 gaagttggca gtggtcaccc gccaatacca cgcggtctgc ttttcggata gctatccagc
     8641 aggcagcctc taaggcctgg gctgcttcat caatgaaaag ggtgccgaaa cggcgtccgt
     8701 tcagcagccg gtgattgctg cttaccagcg tggaggctat gacatgtgcc ccatcaaaaa
     8761 gctctgaatt gatttgtatt tccaatgcgg tggcgcggtc gcgcaggcgg ctcatacggc
     8821 tgcgtactcc ttcgcgttcg tcatagctgc cacggcgggc acggctgccc agttcacgga
     8881 gatttttccg gatgctccac agttccggat aaagcggatg gttctcgaaa cgacgctcgt
     8941 aggtaaagga aagcatcttg tcgttgacac gggtcggatt gccgatacgc aggacattga
     9001 cgccacggtc cacaagtttt tccgaaatcc agtcgacggc ggtattgctt tgggcacata
     9061 ccagtacctg cggttcccga tgcagggttt cgtagatggc ttccactaag gtggtcgttt
     9121 ttccggttcc cggaggacca tgtacaatgg ccacgtcgcg ggcacacagc actttgttta
     9181 cagctgtctc ctgcgtggag ttcagccagg gaaaccgtac ggggtagagc tctcggaaac
     9241 cggctttcga ggctcccagc aatatgtccc gcaattcggc caggcggttg cctttggagc
     9301 gtaacgtatc ttccaaggct tcgaacatgg tccgatagga tgtttcgtcg aaataaagtt
     9361 gcacgccgag gttgtccgtt tcctgcactt ccataacggc accggctccg ggcattatcg
     9421 ctaccatccg tgtctcgtcg gcatagctta cggtagcggt gaagttcata taggttattt
     9481 ttccatcggc agactggcgg aaaaaacata cgggacggcc gaactcaaaa ttatgttcta
     9541 tatcggtatt ttctgtgtgt gtaatttcta ttactaattg attcagtgaa ttatagtaac
     9601 ttcgtcccgg agtggcagga taccagcaaa gtccccgttt cactttccgg gcaatcccca
     9661 tgttttcggt ttggcgtttg aattcctctt tttcgtattc gtattccatg cgcagcaaaa
     9721 gttgttgctg ctggaggtga ataataggac tatttgaatc ttgttccttc atggttgcaa
     9781 aggtaatcat tcttcgcttc cgacggaaaa aatgctttat tttgttaaac tattcagcct
     9841 ttttatttgt ttatgatatt aatttgtaat ctttacaata atgaaaaact aaaaaatagt
     9901 ggttatggta tatgatttaa cgatgctcaa agcgttttat gccgcttatt cggagaagat
     9961 agaacgtgta cggaatgtac tacagcgtcc gatgacttta gcggagaaaa ttttgtatgc
    10021 tcatttgtat gatggggata aagtgaagaa ctacagacgg ggagaagact atgtgaattt
    10081 ccgtcccgac cgtgtggcca tgcaggatgc aacggcccaa atggccttat tgcaatttat
    10141 gaatgcaggc cgtgagcagg ttgccgtgcc ttccactgtg cactgtgacc atttgattca
    10201 agcatataaa ggtgcaaaag aagatatcgc gactgctacg aagaccaacg aggaggtcta
    10261 taattttctc cgtgatgttt cttcccgcta tggcataggt ttttggcagc cgggagcagg
    10321 cattattcac caggtggtat tggagaacta cgcatttccg ggtggaatga tggtaggcac
    10381 ggactctcat acgcccaatg ccggaggttt gggcatggtg gccattggtg tgggtggtgc
    10441 cgatgcggtg gatgtgatga ccggcatgga atgggaactg aaaatgccgc gtctgatagg
    10501 tgtacacttg aagggtaaat tgagtggctg ggtagctccc aaagatgtta ttctgaagtt
    10561 ggcgggtatt cttactgtaa aagggggaac caatgccatc attgaatatt ttggaccggg
    10621 aaccgcttca ttgtctgcca ctggaaaggc taccatctgc aatatggggg cagaggtggg
    10681 ggcgactacc tcccttttcc cttacgatga gcgcatgggt acttatttga aggctaccgg
    10741 acgtgaagaa gtggcaaaaa tggctgcttc cgtagctgcc gaccttcgcg ccgacgacga
    10801 agtgctggca aatccggaaa aatattacga ccgcatcatt gaaatagacc tctcgctgtt
    10861 ggaaccgtat atcaatgggc cctttacgcc ggatgcagca acaccgatat cgaaatttgc
    10921 cgaggtagtg ataaccaata actatccccg ccggatggaa gtcggtctga tagggtcgtg
    10981 caccaattcg tcctatcagg atttgagccg tgcggcctcc cttgcccggc aggtaaagga
    11041 aaagaatttg aaggttgctt ccccgctgat tgtcaatccc ggctcggagc agatacgtgc
    11101 cactgctgaa cgcgacggca tgattgccgc tttcgaagat attggcgcaa cgataatggc
    11161 gaatgcctgc ggaccttgta ttggccagtg gaagcgccat actgatgacc cnnnnnnnnn
    11221 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    11281 nnnnnnnnnn nnnnnnnnnn nnnnnngagg ttgtgaaact gtccgaaccg gtcggtgaag
    11341 aactgccggc acacgggttt ataggaggaa aggaaggata cattgctcca ggcaaaggac
    11401 agacgaaaat tacggtcaat cctcattcac agcgcttgca actgctgact cccttccctg
    11461 cctgggatgg tatggatttg ctggacatgc ctttattgat taaagtgcag gggaaatgta
    11521 ccaccgacca catttccatg gcagggccat ggctccgttt ccggggacat ctggagaata
    11581 tttcggataa tatgctgatg ggagctgtca atgctttcaa tggagagacg aatagtgtct
    11641 ggaatcgctc taccaatacc tatggaacgg tgtcaggcac ggcgaaattg tataaatctg
    11701 aaggtatccc ttccattgtc gttgccgaag agaattatgg tgaaggttcc agccgtgagc
    11761 atgctgccat ggaaccacgc ttcctgaatg tacgcgtcat tttggcgaaa agctttgccc
    11821 gtatccatga gacgaattta aagaaacaag gcatgttggc gctgaccttt acggataagg
    11881 ccgattatga caagattcgg gaacgcgact tgatttctgt catggggttg aaagattttg
    11941 ctccgggacg cactttgaag gtggttcttc atcacgagga cgggagtaaa gaaagttttg
    12001 aagtacaaca tacgtataac gaacagcaga tagcctggtt ccgggccggt tct
//
