LOCUS       c00018_gnlPro..        16484 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|OPODCCMO_19.
ACCESSION   c00018_gnlPro..
VERSION     c00018_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2025-04-29 05:12:44
            Original ID  :: gnl|Prokka|OPODCCMO_19
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16484
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..1128
                     /locus_tag="ctg18_1"
                     /transl_table=11
                     /translation="RLGMVRRWLKTGQAKWFGNSRKTIQFVRPVTTNTQELTLGVDAGF
                     HLGLSVVGNNREYYAAESLRKSEKDRITSRRELRRTRRNRLRYRKARFDNRRRKDSWLA
                     PSIQHRLDFTIKEIKRLYMFLPITNLVVEVTPFDNQKLLNPDIQGWQYQKGKMYGFKTI
                     KDYLLARDNYRDALDGKQYLASQLRVHHLVQRKDGGSNQPDNLVLLSDINHNQTNHNNG
                     ILAKLKENRQKTIDYRGAYFMSVLATRLSNYFDNYTITQGYLTANLRQKYEIEKSHLND
                     AFVIAGGTDITLRTNNVYSRQKLRNNNRVLQKFYDAKYIDSRDGKQKTGKELSSGRTRR
                     SQELNYDNLRQFRKEKVKKGRVSIRRGXXXXKYQN"
     protocluster    1..16484
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3353:6484]"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3354..6484
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
     cand_cluster    1..16484
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /kind="single"
                     /product="Pyruvate2acetate-formate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16484
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Pyruvate2acetate-formate"
                     /region_number="1"
                     /rules="((PFL_acetate1 or PFL_acetate2) and Radical_SAM)"
                     /tool="gutsmash"
     CDS             2077..2379
                     /locus_tag="ctg18_2"
                     /transl_table=11
                     /translation="MNKIIISKLNNDENKIEWRISNSETGHYLNISISRALEDAMKKKR
                     NLSFNRFESEQINNLSHLVTNIQEDYVLNIDESNISSSYLPLKGIDALSYMKTVE"
     CDS             2447..3268
                     /locus_tag="ctg18_3"
                     /transl_table=11
                     /translation="LIKDLSVNNLYFQFDCVIGVSAGSLNGANFVSKQYQRTYNVNVKY
                     RKDHDYISLARPFKHESIINLDFLFDDHGLDWHNFDNKAYLKSETDFIVVATSLESGKA
                     VTLRNPQPGQDLIDVLEASSSMPFISKPHNTSKGLCLDGGIANSIPFDIAQKMGFQKIV
                     VVRTRPRDYRKKPTSFALKRLYSNSFKEYPEFVKTAIRRPEMYNHSVEVLNKLEHNDEI
                     FCLAPNDPVKVGRLEHNTKKMTELYNIGRNDAESNLEAMLNYLQKSEPLYD"
     CDS             complement(3354..4190)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: Radical_SAM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1015:4Fe-4S single cluster domain (Score: 70.1;
                     E-value: 7.7e-22)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg18_4"
                     /sec_met_domain="Radical_SAM (E-value: 3.1e-32, bitscore:
                     106.1, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSANPLLNPVPTKDGHVVGYVHSLETFGAVDGPGIRFVAFMQGCH
                     MRCKFCHNPDTWKTRVGSQMTTEEVLNKALPYRSFWGDKGGITLSGGEILLQIDFALEL
                     FKMCKEEGISTCLDTCGQPFTRREPWFSKFNELMDYTDILLVDIKHINSDEHKRLTGFP
                     NDNILDMCEYLSSIGKPVWIRHVLIPGITDNDEYLKQLGEYVKENLHNVEKFEVLPYHT
                     MGVHKYQEMGIRYRLEGVEPPTPERVKNAEKLLEVDRYQGYKDWYPGINTLDQQPS"
     CDS             complement(4217..6484)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: PFL_acetate2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Gly_radical"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg18_5"
                     /sec_met_domain="Gly_radical (E-value: 7.3e-40, bitscore:
                     129.7, seeds: 99, tool: rule-based-clusters)"
                     /sec_met_domain="PFL_acetate2 (E-value: 9.2e-261, bitscore:
                     860.2, seeds: 33, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVEKTQMQNVDVKDAWEGFRGKEWKEEIDIREFIQDNFTPYDGDQ
                     SFLEGPTEATTKLNDKLIDLKLKERAHGGPLEADTKVVSTITSHKPGYLDKSLEKIVGL
                     QTDKPMKRALMPYGGIRMAKGALEAYGFKIDPETDFVFENLSKTHNQGVFDAYTSEIMK
                     ARHNKIITGLPDAYGRGRLIGDFPRIALYGIDRLIEGKKKDLENCGDGEMTNDVIQMRE
                     EISDQIKALNDMKIMAESYGYDISKPATTAKEAIQWLYFGYLASIKQQNGAAMSIGRID
                     SFIDIYIERDMKRGILTEKEAQELIDQFTMKLRMVCFIRTPAYNSLFSGNPIWATLSIA
                     GMGLDGRHHVTKTSYRFLNTLHNMGAAPEPNITLLWSDRLPESFKHYAASVSIASSTIQ
                     YENDDLMMKTWGTDYYGIACCVSAQPIANGMQFFGARANLAKAVLYAINGGKDELTKQQ
                     VGPAYEPISSEYIDYDEFMKKFDDMMEWIADIYVNALNTIHYMHDKYYYESAQMALKDT
                     LVDRSFATGISGLSVAADSISAIKYGHVKVIRDEDGIAVDFKADHDFPRYGNDDDRVDD
                     IAAWLVKELFTKMSKHHLYRGAKLTTSVLTITSNVVYGKNTGTTPNGRQKGEPFAPGAN
                     PAYGADTTGALASLLSVAKLPYKYATDGISNTFAVTPTTLGHDEKMQEDTLVNMIGGYM
                     RKDGHHLNINVFNRDTLLDAQAHPEKYPTLTIRVSGYCVYFADLTKEQQDDVIARTFHA
                     SM"
     CDS             complement(6795..7379)
                     /locus_tag="ctg18_6"
                     /transl_table=11
                     /translation="VKVMHVLRVKTNFFWDSLNVIRASILGANDGIISVSGIVLGAAGA
                     NLDSKTLLISGLSGMLAGACSMAGGEWISVSTQRDIQEKTMERQSQLENDDCENCPIKL
                     QKNDILMPFHAAASSFCSFIIGAMIPLLTMILARPEHRVVFTLIAMIASLSINAIVCTH
                     NSEVSTSKTILRNVITGLLTTLVTFILGASV"
     CDS             complement(7574..8977)
                     /locus_tag="ctg18_7"
                     /transl_table=11
                     /translation="MISEDIKDIGGQYKYGFKDDIEPIYTTGEGLSEEVVRNISKAKNE
                     PEWMLDIRLAAYEKYKTLKMANFGPDLSELDLDHINYFRRDTDTVARKWEDVPQEIKDT
                     FDRLGVPEAERKYLAGSSAQYESEVVYHNMKEDFAKKGIIFMDTDSAVQEYPELVKKYF
                     GKLIPADDNKMAALNTAVWSGGTFIYVPKGVKVETPIQSYFRINAGNSGQFERTLIIVD
                     EGASVNYVEGCTAPNYSQDSLHAAVVEVNVLKDAYCRYTTIQNWSNNVYSLETKRARAL
                     ENATMEWVDGNLGSKVTMKYPSIYLDGEGAHGNMLSIAFAGKGIDSDTGARMIHNAKNT
                     YSSTVSKSLCKDGGIADYRGYVRFNRDSDGSFAHVECDTIIMDDESSSDTIPFNEVLNS
                     NVSMEHEAKVSKISEDQLYYLMSRGISEEKATEMIIMGFVEPFTKELPMEYAVELNRLI
                     EYQMDGSVG"
     CDS             complement(8970..9419)
                     /locus_tag="ctg18_8"
                     /transl_table=11
                     /translation="MSNLNNLYRQAILEEANHPRHKGKLENKSVEVELRNPTCGDVITL
                     TALIEDNKIKDIAFDGYGCTISQSSASIMTNEVLNKDFDTIKNMVLSFSDMITKEVKPD
                     RKVLGEAIILEGVKQFPARIKCAMLSWKAIYQLIEKYEGKGEKND"
     CDS             complement(9416..10642)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg18_9"
                     /sec_met_domain="Aminotran_5 (E-value: 2.2e-161, bitscore:
                     530.7, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKTSDLRKDFPLLETKMNDQPLTYLDSAATSQKPKQVIDEIADY
                     YNKYNSNIHRGVYNLAVETTDKYENVRHKVAKFINAYRDEEVLFTKGTTQSLNWIAQGY
                     VRYNLHEGDEIVTTYMEHHSNIVPWQAIAQEKNLKVKYVTLTEEGKLDLDDLKQKITDK
                     TKIVAVTHVSNVLGTINPIKEIAAIVHQSNAILVVDGAQSVPHLPVDMQALEADFYVFS
                     GHKMLGPTGIGVLWGKYELLEKMHPLEYGGEMIDSVTTEKSTFKEIPWNFEGGTQNIEG
                     VLGLGAAIDYLEEIGMENVAQNDEDLQKYALEKLANIKSIEIYGPKDPDQRCGVVSFNL
                     KGIHPHDVATFLDADGIAVRAGHHCAQPLMDWLGVSATLRASFYFYNTYEEIDKLVDSL
                     KKVEEFFQI"
     CDS             complement(10629..11879)
                     /locus_tag="ctg18_10"
                     /transl_table=11
                     /translation="MKQLSIDELIELRKEPEWFRAKRNEAKQLIETTKLPSFQKIKYHD
                     WDINVDGTSVIDDQPKFDTNADVYQYASNKAQIKLPSEFLDKGVIVEDFEDALINHEDI
                     MKKYFMEKGLKMDDNRLLAEHVANLQSGVLVYVPKNVDLETPLTCEYIQNSRVEEDYIH
                     HVLIVTEANSSLSYVERLKTDGDKKNTANIVVEVIAGDGSRIHFASVDNLSKNTTAYMN
                     RRGYLQRDSKIDWAMGMMNSGLTIGDFDSDLVGDGSHAELKVVGISTSDQIQGIDTRVT
                     NIGKNTIGHILQHGVALDESELTFNGIGHVMKRSKGSDAQQESRILMLSPQARGDANPI
                     LLIDDNDVTAGHAASIGRVNPEQLYYLMSRGLQKRLAEKLVIRGFLAPVLDEIPLKEIR
                     NEFSELIERKVSYDEEN"
     CDS             complement(11892..12671)
                     /locus_tag="ctg18_11"
                     /transl_table=11
                     /translation="MSVLEVKDLHVTVEGKEILKGVNLKMSTGEIHAIMGPNGTGKSTL
                     SSTIMGDPAYKITKGDILLNGKSIIDLPVDERARMGLFLAMQYPQEIPGVTNAEFVKSA
                     INARRPKDDPIPLMDFIKRLDETLETLDMSEEMADRYLNEGFSGGEKKRNEIMQMMMIR
                     PEFAILDEIDSGLDIDALKVVSRGVNQMRGDNFGSLIITHYQRLLNYIVPDYVHVMMDG
                     QLVKTGGPDLAIRLEKEGYAKLRDELGLDIKLVDENA"
     CDS             complement(12934..14568)
                     /locus_tag="ctg18_12"
                     /transl_table=11
                     /translation="MKRIKAIITGIFISLTAVLLVSCGKSTSENSKQVLNLSTTGPLDT
                     IDISKSTGYGQTGNVFESFYRLGKDGKVTPGLAKSGQVSQDGKTWTFTLRDAKWSNGDK
                     ITAQDFVYSWRRTIDPKTASPYAYLFYDVKNAQAINEGKMSADKLGIKAEGDNKVVITL
                     DRPISYFKVLMTYPLFGPQNEKVVQKYGKKYGTNSKYMVYSGPFKVKDWNGTSDKWSFV
                     KNNQYWDKKVVKLQKINYQVVKNTNTGYQLFQQGKLDLTPLSSEQVKNLHNKPEFKQYS
                     YSYVAYLDYNFNDSNEINRKALNNKNIRLALSLAIDRKTLTKKVFGDGSNVPTGFVASD
                     LANNPKTGKDFAAEQKVDNTADYNEKLAKKYWKKGLQEIGEKNLNFTILASNEMANNDA
                     LTQYLQSQYTKVLPGIKISVQNIPGNSALSKARKGNYDIYVSGWGGDFKDPITFMQIPV
                     TGTSYNYGKYSNKEYDALIEKAQNEDANDANKRWEDLVKAARIFNTDQGVTPLYQQTTS
                     YMQNTKVKGIIQNTAGTQWNYKYAYIK"
     CDS             complement(14976..15074)
                     /locus_tag="ctg18_13"
                     /transl_table=11
                     /translation="MNHSILEIIDDLNDSKLERASNLAELESLLNK"
     CDS             complement(15097..15369)
                     /locus_tag="ctg18_14"
                     /transl_table=11
                     /translation="MYISINSEKTGANLKSLFKNNGYSVRDIQSVMGFENPQSIHKWLS
                     GRSLPSLDNLVILSKVLHTTIEDILVVDGDVVFLFNLTWTIHLNR"
     CDS             complement(15515..16042)
                     /locus_tag="ctg18_15"
                     /transl_table=11
                     /translation="MRKRAKYQKLRATLQAKGTKSTKRRLKKLSGRENRWISDVNHCLS
                     KTLVQRYGANTLFVLENLNGISFERTDLPKTLRNQNKSWAFYQLEQFLTYKAHLNNSEV
                     VEVSAKYTSQRCPKCGVIKKDNRNHEKHEYHCDNCGYRSNDDRIGAMNIQLLGTQYISG
                     QEQPKFELITNA"
ORIGIN
        1 agattaggta tggtgcgtcg ttggttaaaa acaggtcaag caaaatggtt cggaaatagt
       61 cgtaagacta tccaatttgt tagacctgtt actacaaata ctcaagaatt aacactagga
      121 gtagatgctg ggttccactt aggcttatca gttgtgggta acaaccgtga atattatgca
      181 gctgaaagct taagaaagtc agaaaaagat agaattacta gccgaagaga gttaagaaga
      241 actagaagaa atcgtttaag ataccgtaag gctagatttg ataatcgcag acgcaaagac
      301 agttggttag ctcctagtat tcaacataga ttagatttta cgattaaaga aatcaaacgc
      361 ttatatatgt ttttaccgat tactaattta gtcgttgaag ttacaccatt tgacaaccaa
      421 aagttattaa atccagatat tcaaggctgg cagtatcaaa aaggtaagat gtatggcttt
      481 aagacgatta aggattatct gctagctaga gataactatc gtgatgcttt agatggtaaa
      541 caatatctag ctagtcagtt aagagttcat cacttagttc aaagaaaaga tggcggttct
      601 aatcagcctg ataatctagt tttattgtca gatattaatc acaatcaaac taaccataat
      661 aacggtattt tagctaagtt gaaagaaaac cgacaaaaga ccattgatta tcgtggagct
      721 tattttatga gtgttttagc aacaagatta agtaattatt ttgataatta tacgataact
      781 caaggttatc taaccgctaa cttaagacaa aagtatgaga ttgaaaaatc acatttaaat
      841 gacgcttttg tgatcgctgg tggaaccgat ataacactta gaacaaataa tgtttattcg
      901 agacaaaagt taaggaataa taaccgagtg ttacagaagt tctacgacgc taagtatatt
      961 gatagccgag atggtaaaca aaaaactggt aaagaattaa gttcagggag aactagacga
     1021 tcccaagagc ttaattatga caatttaaga caattcagaa aagaaaaagt taaaaaaggt
     1081 cgtgtttcga ttagaagagg tnnnnnnnnn nttaaatacc agaactaaca gaattgaaac
     1141 agttaaagga gttcaaaata gtggaacagt aatcaagttc caaactggca agacttgttc
     1201 aattaaaagt gtagttagct tatatcatgt aaatggaata ttagaaaaga aaatggaaaa
     1261 tatttagttt gcttaggcaa actaggactt acatcccacg actaaagtcg tgggttttac
     1321 gtccatttgt aataaattag aacgtccaac aaaagttaaa ttggtttcct ataaaagcgt
     1381 taaagatgct ttgcctatac ccaacactac aacaggtaaa aatgaattgt tgggatacat
     1441 tatgctagag aataaaaaat tttatcaaga aaataatcgt ccatattacc cccatggtat
     1501 gtcgaacggt ataaaaaatt cttagatcaa aagatcttct aatactgttt aataatagat
     1561 acacttttaa gtctcaattt ctgtaaagat tagggggact tttttattat aattaatttt
     1621 aaattcatct ttctaaaaaa tgtacgtttt tcataaagat ggatagagag aaaaccaaac
     1681 agtgtaatat aatctcatta tagttttatt gattaatttt gatgtttatc aaaaatcata
     1741 ttttttcaga aagttaaaat aactttttat tttataaaaa attgatttcc taagtttgac
     1801 tttaataatc tatctacaat ctgctattta taaaaaaaca aatttacata cttttaattt
     1861 ggctataaca actgattcca ttcaataatt cttcattaaa acaattatat taacatacca
     1921 atccttatat tatattgata ttcaactttt taaataagca aaaacaatta tttacttata
     1981 tttttaattt tacccttgct tttattcgta aatgagagta gagttatact tgtaagttaa
     2041 ggaaagcatt tacatttatt aaggtggtaa ttatatatga ataaaattat tattagcaag
     2101 ttaaacaatg acgaaaataa gattgaatgg cgtatttcta acagtgaaac tggacattac
     2161 ttaaatattt caatttcccg tgcattagaa gatgctatga agaaaaagcg taatttatcc
     2221 tttaaccgct ttgaatctga acaaattaac aatttgtctc acttagttac aaacattcaa
     2281 gaagactacg ttcttaatat tgatgaatca aatattagtt ctagttattt accattaaag
     2341 ggtatcgacg cattatcata tatgaaaacc gtcgaataag tgattataag cattaaatta
     2401 agttgttatt ttaatactta tcttggatat acttaagtat tcttaattga ttaaagattt
     2461 atctgtcaac aacctctatt ttcaatttga ttgtgttatt ggagtttctg cagggtctct
     2521 aaatggcgct aatttcgttt caaaacaata tcaaagaact tataatgtaa atgttaaata
     2581 ccgtaaagat catgactata tctccttagc acgccctttt aagcatgaaa gtattattaa
     2641 cttagatttc ttatttgatg atcatggatt agattggcat aatttcgata ataaagccta
     2701 tttaaagtct gaaactgatt ttattgttgt agctacttct ctagaaagcg gaaaagctgt
     2761 aacgctacgt aatccccaac ctggtcaaga tttaattgat gtcttagaag cttcttcatc
     2821 tatgcctttc atctcaaagc cacataatac ttctaaagga ctttgtctag atggtggtat
     2881 tgctaactct atcccttttg atatcgctca aaaaatgggt tttcaaaaaa ttgtagttgt
     2941 tcgtactcgc ccacgtgatt atcgcaaaaa gcctactagt tttgctttaa aacgcctcta
     3001 cagtaatagc ttcaaggaat acccagaatt cgttaaaacg gctatcagac gtcctgaaat
     3061 gtataaccat tctgttgaag ttttaaataa acttgaacac aacgacgaaa ttttttgttt
     3121 agcacccaat gatccagtta aagttggtag gcttgaacac aatactaaaa agatgactga
     3181 actctataat ataggtagaa atgatgctga aagtaatctt gaagcaatgc ttaactatct
     3241 tcaaaaaagt gaacccctat atgactaaaa atacatttta aaaccaaaaa acatggtatc
     3301 tacttagcaa aactaagcga taccatgttt ttattttata tttgccaatt tagctagctt
     3361 ggttgttgat ccaaagtatt aatgcctgga taccaatctt tatatccttg atatctatct
     3421 acttctagca gtttttcagc attttttact ctttctggcg taggaggctc aacaccttca
     3481 agacgatatc tgatacccat ttcctgatac ttatgaacgc ccattgtatg ataaggtaat
     3541 acttcaaatt tttcgacatt atgaagattt tccttaacat actcgcccaa ttgtttcaag
     3601 tattcatcat tatccgtgat gcctgggata aggacatgac gaatccaaac aggtttccct
     3661 atactagaaa gatattcgca catatccaaa atattatcat ttgggaatcc ggttaatctc
     3721 ttatgttcgt ccgaattaat atgcttgata tcaactaata aaatgtcggt atagtccatt
     3781 aactcattga acttactaaa ccaaggttct cttcttgtaa atggctgtcc acaagtgtcc
     3841 aaacaagtgc taataccttc ttccttgcac atcttgaata actctagtgc aaaatctatt
     3901 tgcaatagaa tttcaccacc tgataaagtt attccacctt tgtcgcccca aaagctgcga
     3961 taaggaagtg ccttgtttag aacttcttca gtcgtcattt gtgaacctac ccttgttttc
     4021 caagtgtccg gattgtgaca gaacttacac ctcatatggc aaccttgcat aaaagcgaca
     4081 aaacgtatac ctggtccatc aacagctcca aaagtttcca aagagtgtac atatcctacg
     4141 acatgaccgt ctttagttgg aactggattc aataaaggat tagcactcat tctctccacc
     4201 tactctcttc taattattac attgaagcat ggaaggttct tgcaataacg tcatcttgtt
     4261 gttctttagt taaatcagca aagtatacac agtaacctga aacacgaatt gttaatgttg
     4321 gatacttctc tggatgtgct tgagcatcta ataaagtatc tctgttgaat acattaatat
     4381 tcaaatgatg accatctttt ctcatatagc ctccgatcat gtttaccaat gtatcttctt
     4441 gcatcttttc atcatgaccc aatgttgttg gtgttacagc aaatgtatta gaaataccat
     4501 ctgtagcata cttgtatggt aatttagcaa cggataatag tgatgctaaa gcacctgttg
     4561 tatctgctcc gtatgctggg ttagcacctg gtgcaaatgg ttcacccttt tgacgaccat
     4621 ttggagtagt acctgtgttc ttaccataaa caacatttga agtaattgta agaacggatg
     4681 ttgttaactt agctccacga tatagatgat gcttgctcat cttagtaaat agttccttaa
     4741 caagccatgc agcaatatcg tcaacacgat catcatcgtt accataacga gggaagtcat
     4801 gatctgcctt gaagtcaaca gcaataccat cttcgtcacg aattacttta acatgtccgt
     4861 acttgatagc tgaaattgag tcagcagcaa cagacaatcc agagatacct gtagcaaagc
     4921 tacgatctac caatgtatct ttcaatgcca tttgtgctga ttcatagtaa tacttgtcat
     4981 gcatgtaatg aattgtgttc aaagcattta cgtaaatatc agcaatccat tccatcatgt
     5041 catcgaattt cttcatgaat tcatcgtagt caatgtattc tgagctaatt ggttcgtatg
     5101 caggacctac ttgttgtttt gtaagttcat ccttaccacc attgatagca tacaatacag
     5161 ccttagctag atttgcacga gctccgaaga attgcatacc atttgcaatt ggttgtgcag
     5221 atacacagca agcaatgcca tagtagtctg ttccccatgt cttcatcatt aagtcatcgt
     5281 tttcgtattg aattgtagaa cttgcaatag atacacttgc agcatagtgc ttaaatgatt
     5341 caggcaaacg atcagaccaa agtaatgtga tatttggttc tggtgcggca cccatattat
     5401 gcaatgtgtt taagaaacga tatgatgtct tagttacatg gtgacgtcca tctaagccca
     5461 taccagcaat tgataatgtt gcccagatag ggttacctga gaatagtgag ttgtaagctg
     5521 gtgtacgaat gaagcatacc attctcaatt tcattgtgaa ttggtcaatt aattcttgtg
     5581 cttctttttc agttaaaata ccacgcttca tatcacgttc aatgtaaata tcgatgaatg
     5641 aatcgatacg accaatagac atagcagcac cattttgttg cttgatagat gctaagtaac
     5701 caaagtatag ccattgaatt gcttctttag ctgttgtagc tggtttagaa atgtcatagc
     5761 cataggattc agccataatc ttcatatcgt ttaaggcttt gatttggtca gaaatttctt
     5821 cacgcatttg gattacgtcg ttagtcattt caccatcgcc gcaattttcc aaatccttct
     5881 tctttccttc gatcaaacga tcaataccgt ataatgcaat acgtgggaag tctccaatca
     5941 aacggccacg accatatgca tctggtagtc cagtgataat cttgttgtgg cgagctttca
     6001 tgatttcgct tgtgtatgca tcaaatacac cttggttatg cgtcttagat agattttcaa
     6061 atacgaagtc tgtttctgga tcaatcttga atccataagc ttccaaagca cctttagcca
     6121 ttctgatacc accatatggc ataagtgcac gtttcatagg tttatctgtt tgtaaaccaa
     6181 caatcttttc taatgacttg tctaaataac ctggtttatg agatgtaatt gttgatacta
     6241 cttttgtatc agcttcaaga ggtccaccat gtgcacgttc ttttaatttt aagtcgatta
     6301 atttatcgtt taacttcgtt gtagcttcgg ttggtccttc aaggaaagat tgatctccat
     6361 catatggagt gaagttatct tgaataaatt cacgaatatc aatttcttct ttccattctt
     6421 ttcctctaaa tccttcccaa gcatctttta catcaacgtt ttgcatttga gtcttttcaa
     6481 ccatgctcaa agcctccttt gtgattttta agaaaacgtt ttctacactg ttaatactac
     6541 accttagtta aattaaattc aatgaaaaat cgttcacaat gttttttatt ttcaaaaaat
     6601 cttataaacg ctatcattta ttttaatcat tataaatgtt aatatgacaa tacttttgac
     6661 aacagtttat aaactttaaa aatgtgattt atgtatcaaa atataaattt cattaatttt
     6721 attttagaat ttcttaaaat tacaaaaaaa gaccctatat ccaaaaaatt taggtataga
     6781 gtctttaaaa gtatttatac tgatgcccct aaaataaagg taactaacgt cgttaacaat
     6841 ccagttataa catttcgtaa aattgttttg ctagttgaaa cttcggagtt gtgtgtacaa
     6901 actatcgcat taattgataa tgaggcaatc atcgcaatta atgtaaatac cacgcgatgc
     6961 tctggtcttg ctaggatcat cgtcaataat ggaatcattg ccccaattat aaatgaacag
     7021 aaagaactgg ctgcagcatg aaacggcatt aagatatcat tcttttgcaa ttttatcgga
     7081 caattttcac agtcatcatt ttccaactga ctttgtcttt ccattgtttt ttcttgaata
     7141 tctctttgag tgcttacaga tatccattct ccaccagcca ttgaacaagc tccagctagc
     7201 atgccagata agccactgat taaaagggtc ttactatcaa gattagcccc agcagcacct
     7261 aacacgattc cagatactga aataattcca tcattggcac ctaaaatact agctctgata
     7321 acattcaaac tatcccagaa aaaattagtt tttactctta atacatgcat aactttcact
     7381 ttgtacactt cctcacgaat ttcgcaaaaa tatcattttt tatatgtact gtcaaatata
     7441 tgtaaaccgc tttatttacg attaaattat acattatatt aggatttatt actaatttag
     7501 caaaacttat aattatatac atgtttcaca atgttataaa aaaagcatac ctaaaaagta
     7561 tgctttaata cgattaacct acactaccat ccatttggta ctcaattaat ctattcaatt
     7621 caacggcata ttccattggt aattctttag taaatggttc aacaaagccc ataataatca
     7681 tttcagtagc tttttcttct gaaatacctc tactcattag atagtaaagt tgatcttctg
     7741 aaatttttga aaccttagct tcatgttcca ttgaaacatt actattcaat acttcattaa
     7801 atggaattgt atcacttgaa gactcgtcgt ccataatgat agtgtcacat tcaacgtgtg
     7861 caaatgagcc atcgctatct ctgttaaatc ttacatatcc acgatagtca gcaattcctc
     7921 catctttgca gagagattta gatacagttg atgaatatgt atttttagca ttatgaatca
     7981 ttcttgctcc agtatcagag tcaatacctt tacctgcaaa tgcaatagat aacatgtttc
     8041 catgtgcacc ttcaccatct aaatagatac ttggatattt catggttact ttagaaccaa
     8101 ggttaccgtc tacccattcc atagtagcat tttccaaagc tctggcacgt tttgtttcca
     8161 aactatatac gttgttggac cagttttgaa ttgttgtata acggcaataa gcatccttca
     8221 aaacatttac ttcaacaact gccgcatgta aggagtcttg tgaataatta ggagctgtac
     8281 aaccttctac atagttaacg ctagcacctt catcgacaat gattagtgtt ctttcaaatt
     8341 gtcctgaatt tccggcatta attcggaagt aactttgaat aggtgtttca acctttactc
     8401 ccttaggtac gtaaataaat gttccaccag accaaacagc tgtattaaga gctgccattt
     8461 tattatcatc tgctggtatt aactttccaa agtatttctt tactaattct ggatattctt
     8521 gaactgcaga gtctgtatcc ataaatatga tgcctttttt ggcaaagtct tctttcatat
     8581 tatggtaaac aacttctgat tcatattgag cagaagaacc agctaaatat ttacgttcag
     8641 cctctggtac acccaatcga tcaaatgtat ctttaatttc ttgtggtaca tcttcccact
     8701 ttctagctac tgtatcagta tcacgtctaa aataattaat atgatctaaa tccaactctg
     8761 acaaatctgg tccaaaatta gccatcttca aagtcttgta cttttcataa gcagccaatc
     8821 taatatctag catccattca ggttcatttt tagctttaga aatatttctt acaacttctt
     8881 cactaagacc ttcaccagtt gtataaattg gttcaatatc atccttaaag ccatatttat
     8941 attggccacc aatgtctttt atatcttcac taatcattct tttcaccctt tccttcatac
     9001 ttctcaataa gttgataaat tgccttccat gataacattg cgcatttaat tcgagcgggg
     9061 aattgtttaa ccccttctaa aattattgcc tcacctaaaa cttttctatc aggttttact
     9121 tcttttgtaa tcatatcgga aaatgacaat accatgtttt ttattgtatc gaagtcttta
     9181 tttaatactt catttgtcat aatacttgcg gatgattgag aaattgtgca accatagcca
     9241 tcaaaagcaa tatcttttat cttattatcc tcaattaatg cagttaaggt aataacgtcg
     9301 ccacaagtcg gattcctcaa ttcaacttca acacttttat tttctaactt acctttatgt
     9361 cgtggatggt tagcttcttc taaaattgct tgtcgatata aattatttaa attactcata
     9421 tttggaaaaa ttcctctact ttctttagag aatctactaa tttgtcgatt tcttcataag
     9481 tattataaaa atagaaactt gctctcaaag tagcactaac acctaaccaa tccataagtg
     9541 gttgtgcaca atggtgacca gctctaactg caattccatc agcatccaaa aaggttgcta
     9601 catcgtgggg atgaataccc ttcaaattaa aggacactac tccacatctt tgatcaggat
     9661 ctttaggacc ataaatttca atagacttga tattagctaa cttttcaagt gcatattttt
     9721 gtaagtcttc atcgttttga gccacatttt ccattccgat ttcttctaaa taatcaatcg
     9781 cagcaccaag acctaatacg ccttcaatat tttgtgttcc accttcaaaa ttccaaggaa
     9841 tctctttgaa tgttgatttt tcagttgtta cactgtcaat catttctcca ccatattcta
     9901 aaggatgcat tttttctaag agttcatact ttccccagag aacaccaatt ccagtaggtc
     9961 ctaacatttt atggccagaa aatacataaa agtctgcttc taaagcttgc atgtctactg
    10021 gtaaatgtgg tacagattga gcaccatcca ctactaaaat tgcattactt tgatgaacaa
    10081 tagctgcaat ttctttaatt ggattaattg ttcctaaaac gttagaaaca tgagtaactg
    10141 ctacaatctt tgttttatca gtaatctttt gctttaaatc atctaaatca agtttacctt
    10201 cttcagttaa agttacatac tttaccttta gattcttttc ttgtgcaatt gcttgccatg
    10261 gaacaatatt actgtgatgc tccatatagg tggtaacaat ttcatcgcct tcatgcaagt
    10321 tatatctaac ataaccttgt gctatccaat tcaaactttg agttgttcct ttggtaaaaa
    10381 gcacttcctc atcgcgataa gcattaataa attttgccac tttatgtctt acattttcat
    10441 atttatcagt tgtttcgact gctaaattgt agacaccgcg atgaatattg ctattgtatt
    10501 tattataata gtctgcaatt tcgtcaatta cttgcttagg cttttgcgaa gtagctgcac
    10561 tatctaagta agttaaaggc tgatcgttca ttttagtttc taaaagagga aaatctttcc
    10621 ttaaatcact agttttcttc atcataactt acctttcttt caatcaattc actaaactca
    10681 ttgcgaattt ctttcaaagg tatttcatct aaaacaggag ctaggaaacc tctaattacc
    10741 aatttttcag ctaaacgttt ttgtaagcca cgactcatta agtaatataa ttgttcagga
    10801 tttacacgac caatacttgc cgcatgtcct gcagtaacat cattatcatc aattagcaaa
    10861 attggattag catcccctct agcttgtgga gataacatta aaatacgact ttcttgttgt
    10921 gcatcagagc ctttacttct cttcattaca tgtccgatgc cgttgaaagt taattcggat
    10981 tcatctaaag caacaccatg ttgtaagata tgaccgattg tattctttcc aatatttgta
    11041 actcgtgtat caattccttg aatttgatca cttgttgaaa tacctacgac ttttaattca
    11101 gcatgagagc catcgccaac taaatcagaa tcaaaatcac cgattgttaa accagaattc
    11161 atcataccca ttgcccagtc aatcttggaa tctctttgta agtatccacg gcgattcata
    11221 taagcagttg tgttcttact taaattatcg acactagcaa agtgaattcg acttccatca
    11281 ccagcgataa cttcaactac gatgttagct gtatttttct tatcaccatc tgtttttaaa
    11341 cgttctacat aagatagtga actatttgct tctgtaacaa ttagtacatg atgaatataa
    11401 tcttcctcaa ctcgtgaatt ttgaatatat tcgcatgtta atggtgtttc taagtccaca
    11461 tttttaggta cataaactaa aactccactt tgaagatttg ctacatgttc tgctaacagg
    11521 cgattatcgt ccatttttaa tcctttttcc ataaagtatt tcttcataat gtcttcatga
    11581 ttaatcaaag catcttcaaa gtcttcgaca attacaccct tatcaagaaa ttctgatggt
    11641 aacttaattt gtgccttatt actagcatat tgatagacat cagcgttagt atcaaattta
    11701 ggttgatcat caattacact cgtcccatca acatttatat cccagtcatg atacttaatt
    11761 ttttggaaac taggcaattt agtagtttca attaattgtt tagcttcatt tcgcttagct
    11821 ctaaaccatt cgggctcttt tcgaagttca atcaattcat ctatggataa ttgtttcatt
    11881 gtacaagccc cctaagcgtt ttcatcaact aatttaatat ctagtccaag ttcatcacga
    11941 agttttgcgt atccttcttt ttccaaacga attgccaaat ctgggccacc agttttgaca
    12001 agttggccat ccatcataac atgtacataa tctggaacga tgtaattcaa gagtctttga
    12061 tagtgagtaa taatcaaaga tccaaaatta tcgccacgca tttggttgac accacgagaa
    12121 acgactttaa gtgcatcaat atctagtcca gagtcaattt catctaatat tgcgaattcg
    12181 ggtctgatca tcatcatctg cataatttca ttacgtttct tttcaccacc agaaaagcct
    12241 tcgtttaaat atctatcagc catttcttca gacatatcca atgtttctaa tgtttcatct
    12301 aaacgtttga tgaaatccat taaaggaatc ggatcatctt tgggacgacg agcattgatc
    12361 gcactcttaa caaattctgc attagttact cctggaattt cttgtggata ttgcatcgct
    12421 aaaaatagtc ccattctagc acgttcatca actggtaaat caatgatact tttaccattc
    12481 aataaaatat ctccctttgt aatcttgtaa gcaggatctc ccataatagt tgaagaaagt
    12541 gttgattttc cggtaccgtt tggacccatg attgcatgaa tctcaccagt tgacatcttc
    12601 aaattaacgc ccttcaatat ttcctttcct tcaacagtta catgtaaatc tttaacttct
    12661 aatactgaca tttaaatcac cactataaaa tagttacctt tcctggaatt ttcttatcaa
    12721 taataattat aagacaaatt actcaacata acgattagat ttaagtattt ttacaatata
    12781 tatccttaaa tttatttgta attaagtaat aatctttata ataagtttac aaatatagaa
    12841 taacgcttac atacaacata atcaatactc ttatgcaaat tatttagcac aacttaaaaa
    12901 ctcgcctaga aatcattcta gacgagttct tacctattta atataagcgt atttatagtt
    12961 ccattgtgta cctgcagtat tttgaataat gccctttact ttggtgtttt gcatataaga
    13021 tgttgtttgt tgatatagag gtgttacccc ttgatcagta ttaaagattc gagcagcttt
    13081 aactaaatct tcccaacgct tattagcatc attggcatct tcattttgtg ctttttcaat
    13141 taaagcatcg tactctttat tagaatactt tccataattg tatgaagttc ctgtaactgg
    13201 aatttgcatg aaagtgattg gatctttgaa gtctccaccc caaccagata cataaatatc
    13261 atagttacct ttgcgagctt tagataatgc actatttcca ggaatgtttt gcacagaaat
    13321 cttaattccc ggtagtacct ttgtatattg tgattgtaaa tattgagtta aggcatcatt
    13381 attagccatt tcattagaag ctaaaattgt gaaatttaaa ttcttttcac caatttcttg
    13441 taatcccttc ttccaatatt tcttagctaa tttttcatta taatcagccg tattatctac
    13501 tttttgttct gcagcgaaat ctttacctgt tttcggatta ttagctaaat cagatgctac
    13561 aaaaccagtt ggtacattag atccatcgcc gaaaactttc tttgtaagtg tctttctgtc
    13621 gatcgctaat gatagagcta atctaatatt tttattattt agtgccttac gatttatttc
    13681 attagaatca ttaaagttat agtctaaata tgcaacgtaa gaataagagt attgcttgaa
    13741 ttctggcttg ttatgtagat tcttaacttg ctcactagat aatggtgtta aatctaactt
    13801 accttgttgg aataattgat aacctgtatt ggtattttta actacttgat agttaatctt
    13861 ttgtagtttt actacttttt tatcccaata ttgattattc tttacaaatg accatttatc
    13921 cgaagtacca ttccaatctt taactttaaa tggtcctgaa tacaccatgt atttagaatt
    13981 agttccatat ttcttaccat acttttgtac tactttttca ttttgtggtc caaataatgg
    14041 atatgtcatt aagactttaa aatatgatat aggtctatct aatgtaataa caactttgtt
    14101 atcaccttca gcctttatac ctaacttgtc agctgacatt ttaccctcat taatagcttg
    14161 agcattcttt acatcataga acaaataagc atatggcgaa gctgtcttag gatcaattgt
    14221 tcttctccag gaatatacaa aatcttgagc agtaatctta tcaccgttac tccactttgc
    14281 atctctcaaa gtaaaagtcc atgttttgcc atcttgtgaa acttggccac ttttagctaa
    14341 tccaggggtt actttaccat ctttacctaa acgataaaaa ctttcaaaaa cattcccagt
    14401 ttgaccataa ccggtagact tagaaatatc aatggtatcc aatggtccag ttgtacttaa
    14461 atttaaaact tgcttagaat tttcactagt tgatttacca catgaaacta acaaaactgc
    14521 ggttaaactt ataaatattc cagtaataat tgctttaatt cttttcatct ttattttctc
    14581 ctttatgtaa gatatgtttt taatctataa acagttcatc atccatcctt ccagataaac
    14641 aaaaaggact tgcaactcca aaaaattaga atcgcaagtc cagttattat tatctcatat
    14701 aatctaactg attaaattaa tctgcatcgg taccgataat aaatatatac agtttaatcc
    14761 aatcttggaa gtgtgaatct aattttctgc ataccaaaat ccatgttgcc tactgaacaa
    14821 catgttacca aacaacagca ttgtgtattg ataaagtttg acatagtgat tcacactcct
    14881 ctcatttctt taaccaaatc atataacctt actatacttt tgtcaataaa ttttaattat
    14941 aagtttgcat tttctaattt ttggcaaaaa taatattact tatttaataa actctctaat
    15001 tcagctaaat tgcttgctcg ttctaattta gaatcattta aatcatctat aatttctaag
    15061 atagaatggt tcatcctata tgtttccttt taattattat ctatttaaat gtatagtcca
    15121 agttaaattg aataaaaaaa caacatcccc gtcaacaacg aggatgtctt cgattgtagt
    15181 atgtagaacc ttactgagaa tgactaagtt atccaaacta ggtagtgatc taccagataa
    15241 ccatttatga atggattgtg gattttcaaa tcccataact gattgaatat cacgtacact
    15301 gtacccgttg ttcttgaata aactttttag gttagcacca gttttttctg aatttatcga
    15361 aatatacatt ggctccgtca actgccccag tctaaagacg tggggcttgt aactcacgac
    15421 tttacggtca gtggtaataa cgcaacttcg ttgctcccac actatacgtg gttacatcat
    15481 tgggtggttg acaacaccca cttaactaac acgtttacgc attagttatt aattcaaatt
    15541 taggttgttc ttgtccacta atatactgag ttccaagcaa ttggatattc atagctccaa
    15601 tacggtcatc attagaacga taaccacaat tatcacagtg atattcatgt ttttcatgat
    15661 tgcgattatc ttttttgata actccgcatt taggacaacg ttgagatgta tatttggcag
    15721 aaacttcaac aacttcacta ttgtttaggt gtgctttata agttaaaaat tgttctaatt
    15781 gataaaaagc ccatgattta ttttgattac gcaaagtttt aggtaagtca gtacgttcaa
    15841 aagaaatacc attaaggttt tctaatacaa ataaagtatt agcaccatat ctttggacaa
    15901 gtgtcttaga caagcaatga ttaacatcac ttatccaacg gttctctcgt ccagataatt
    15961 tctttaaacg tcttttagtt gacttagttc ctttagcttg taaggtggca cggagttttt
    16021 gatatttagc acgtttacgc ataattgctt gaccgtcaaa aaaggcagtt ttgccttgtt
    16081 catcataact agtagctaaa aagcgtaaac cacggtcaat tccgacaaca tgttttacgg
    16141 cttgtttatc aaaatcagta acttctttag tggctgaaat atgtaaatac cacttgccac
    16201 tagatttaag taatttagct aagccaaatt tccaagtacc gtcaaggtac tgattgaatc
    16261 cacgacaaat aggatcaact ttgnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    16321 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    16381 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    16441 nnnnnnnnnn nnnnnnacca atttagatca cgtacttcac gata
//
