LOCUS       c00028_gnlPro..        15678 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|DGDGGOJB_30.
ACCESSION   c00028_gnlPro..
VERSION     c00028_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2025-04-29 05:14:07
            Original ID  :: gnl|Prokka|DGDGGOJB_30
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15678
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15678
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[441:5678]"
                     /cutoff="10000"
                     /detection_rule="(Proline_reductase and (Pro_racemase or
                     GRDB) and not ACP_syn_III_C)"
                     /neighbourhood="10000"
                     /product="proline2aminovalerate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      442..5678
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Proline_reductase and (Pro_racemase or
                     GRDB) and not ACP_syn_III_C)"
                     /neighbourhood="10000"
                     /product="proline2aminovalerate"
                     /protocluster_number="1"
     cand_cluster    1..15678
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Proline_reductase and (Pro_racemase or
                     GRDB) and not ACP_syn_III_C)"
                     /kind="single"
                     /product="proline2aminovalerate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15678
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="proline2aminovalerate"
                     /region_number="1"
                     /rules="(Proline_reductase and (Pro_racemase or GRDB) and
                     not ACP_syn_III_C)"
                     /tool="gutsmash"
     CDS             442..2346
                     /gene_functions="biosynthetic (rule-based-clusters)
                     proline2aminovalerate: Proline_reductase"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg28_1"
                     /sec_met_domain="Proline_reductase (E-value: 2e-191,
                     bitscore: 629.1, seeds: 11, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSISVEQAKEHAKDPAVLCCRREAGKVLEAADFEDPTLFDDYVSS
                     GLLEIPEDTLTIEQALGATLNTTTDALNPLVPGIVDNIQGNEEASESDKDENVEEETPV
                     VAEANNEVVNSTSSNGTFHLRIAKGEGIDLEIPLDVLKKNTANSAVDVPKAETSADVTN
                     KDVAEDEESAEDAKVVRTLTKKYFKVDEVKFGDTTKFDGTTLYLRNPKELCKEAVDTEA
                     IVKGMEIEIITPDDYSNYSNTIMDVQPIATKEGDSDLGVGVTKVVDGAVVVLTGTDENG
                     VQVGEFGSSEGPLNENIMWNRPGAVDKGEIMIKIDVVIEAGTNRERKGPLGAHLAADYI
                     TQEIREALKDVDDSSAVRTEEFVQKRHPKQKRVLIVKEIMGQGAMHDNLIMPVEPVGTL
                     GAKPNVDLGNLPVVLAPTELLDGGVHALTCIGPASKETSRHYFREPLVEEAMADEDIDL
                     VGIALVGSPQENVQKFYVSKRLGMMVEAMNLDGAIVTTEGFGNNHIDFASHIEQIGERG
                     VDVVGMTYAAVQGQLVVGNKYMDAMVDNNKSRQGIENEILENNTLSREDAIRALAMLET
                     KMAGGSIKKPERQWNPNVKQNNIEIIEKETGKKIDLVENEQSLPMSKKRREIYEKDAQ"
     CDS             2348..2665
                     /locus_tag="ctg28_2"
                     /transl_table=11
                     /translation="MEEQSTGFDKLKYASTERVWEGIIIELTDASVIIDLKGRLGRLEI
                     PNRMIISDYELKVGQEVAFLMSYPEVLDSEPNQKYLGALNAYHKKMKEIKEKQRRDKNE
                     S"
     CDS             2655..3107
                     /gene_functions="biosynthetic (rule-based-clusters)
                     proline2aminovalerate: GRDB"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg28_3"
                     /sec_met_domain="GRDB (E-value: 2.5e-21, bitscore: 69.9,
                     seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLKKYDGLQSEIFVPITPTPVWAPVKKKLKDMTVAIVTAAGVHL
                     KSDKPFNLAGDTSYRVVPSTATDDELMVSHGGYDNTDVNRDINCMFPIDRLRELAEKGF
                     IKNIAPNMYTCMGGGGDVKVFTEETGPEIAQKLLDEHVDAVVMTAG"
     CDS             3135..3380
                     /locus_tag="ctg28_4"
                     /transl_table=11
                     /translation="VQRAIESVGIPTIIIAALPPVVRQQGSPRAVAPRVPMGANAGEPH
                     NVEMQTGILKDTLEQLEKLDSPGKIVPLPYEYIANI"
     CDS             3400..4140
                     /gene_functions="biosynthetic (rule-based-clusters)
                     proline2aminovalerate: Proline_reductase"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg28_5"
                     /sec_met_domain="Proline_reductase (E-value: 2e-48,
                     bitscore: 158.8, seeds: 11, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDDILKIREFHVKDVVFGDGYSFKDSVLTIPQSVKFDLPKEILS
                     INIRIIKKDNRHLKVNSIMDIIPISTKVSGKIGTGVSHTLTGVEVMLTGASASGIQIHD
                     FGSSDGYLDEKMVFGRNGTPDEDDIIIGLDVITAEDYSLDRAVITKIFELVDDFIQPIR
                     KILKVTNGRYADYVGEYRNNVSNGKPKVVVIKQVSGQGAMYDNILFPNEPCGIKGGVSI
                     IDMNNFPTIVTPNEYRDGIIHALV"
     CDS             4161..4634
                     /gene_functions="biosynthetic (rule-based-clusters)
                     proline2aminovalerate: Proline_reductase"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg28_6"
                     /sec_met_domain="Proline_reductase (E-value: 2.8e-24,
                     bitscore: 79.5, seeds: 11, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGVGPSTKETTLHHYHDPLVKVFGDDPDIDFQGVVIVGTPQDNKL
                     KEEVGYRVAKFLKAMRTNGAVISADGWGNSDVDFMNTIESIGDEGISIIGLKFIGTQAT
                     FVVSNEYTPYVLDINKSEKGIETTVVGENNLDERDAHKALGYLKLKMRSDGNS"
     CDS             4659..5678
                     /gene_functions="biosynthetic (rule-based-clusters)
                     proline2aminovalerate: Pro_racemase"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg28_7"
                     /sec_met_domain="Pro_racemase (E-value: 1.2e-126, bitscore:
                     415.8, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLSQMLNVIDSHTAGEPARIVVGGIPVLKGKTVAEKKQYLIDHK
                     DNLRKSIMLEPRGHNAMFGAFLIPAISDEADFGIIFMDTGGYLNMCGHNTIAAVTAIVE
                     TGMVDVDEDTREKDVTLETPAGLVHATAHLDSPYHVKNVSFRNVPAFLYKKDVVVDVPD
                     VGKVKMDISFGGSFFAILDIEQLNETIDSSNAEKLDSIGMKILKAVNEQVKVQHPTLDY
                     INTVDLVEMYSKHPQSEDATMQNVVVFGDGQVDRSPCGTGTSAKLATLFAKGEIGINEK
                     FVYESILNTEFTGKVVEKVNIGGVDAITPEITGSAYLTGFNTLLFDPSDPLSNGFELK"
     CDS             5691..6569
                     /locus_tag="ctg28_8"
                     /transl_table=11
                     /translation="MNLVLVIQIILGVCLVFFTIIWLKDLIKNKNKLNDGNLLLAGVIG
                     FVTNFFDTLGIGSYAPTTMLLKLTKYMKNDKLLPGTLTIACSIPVLTEAFLYINTVKVE
                     AATLLSLIVAASVGSFLGSKFISRIDEKKIQVMMGFALIITAILMCLSNTGVLASLGNG
                     NVAVGLTGWKLFIGILGNFILGALMTAGIGLYAPCMAMVYLLGLSPLVAFPIMMASCAV
                     LMPVASREFIKDGNYNRNATIGITIGGILGVFVAVTLVKSMSLTLLTWLVIIVLIYTAI
                     TMLMQGFKKEA"
     CDS             6665..8263
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AA_permease_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg28_9"
                     /sec_met_domain="AA_permease_2 (E-value: 9.6e-49, bitscore:
                     159.9, seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNKKKISLFSGVMLALSSLIGSGWLFGSEQAAKVAGPAAIISWI
                     IGAIIMMVIAFNYVELGTMFPESGGMSRFAQYSHGSFLGFIAAWGNWVSLITLIPIESV
                     AAVQYMSSWPWSWANWTAKFFHGSSITTQGLLMVYLFMIVFTLINFWSVRILTRFTSLI
                     SFFKLIVPTLTIIVLLVEGCHPGNFGHSVSTFMPYGTSSIFEATTVSGIILSYDAFQTV
                     INMGGEMEKPEKNILRGIVISLTITALIYIMLQVTFISSVDPRLIASVGWKGISFTSPF
                     ADIAILLNLNWLSILLYTDAFVSPFGTGVAFVATSARTLSAMTKNGTVPPVLGKLNKKY
                     GIPRYAMAADLGLAMILVFFFRDWSKLATVVSISTFIAYLTGPVSAVALRKLRPNFKRP
                     FKSNWLYVLAPVSFVLTSMVIYWAMWPTTVEVIFVVLLGLPLYFYYESKNMRTTWKEQL
                     HGGLWMVVYLIFISLMSYFGSKGYGGNNTIKYPMDFVIVIVGSLIIYVWAVASRIDNPD
                     LDDAEKLNNTVKSEN"
     CDS             8356..8982
                     /locus_tag="ctg28_10"
                     /transl_table=11
                     /translation="MRKVDALGLECPIPVVKTKKALEEDDVVEVLVDNDTSVKNLEKMA
                     KQKEYGFKVDKEENHYKITISKNNDTETAVEEKHKNEKIMKSTIEDITFESPKGYIVVI
                     NTDSVGHGDEKLGKILLKSFIYSLTGQDVLPEYILLYNGGVKLTVEDSDSFQDLKDLEE
                     AGVKIMSCGICLDYYDLKDKMSVGEVTNMFRIVELMRTANRVVRP"
     CDS             9069..9347
                     /locus_tag="ctg28_11"
                     /transl_table=11
                     /translation="LKKQPFTMIVFNSTHAAIEASEILKNNKQVNRIVNTPGKIENGCG
                     LSIYVNDTNIDKITEPIQSFFDDKKVKAIYSGEKEGLSRSYTLVKEI"
     CDS             9350..11239
                     /locus_tag="ctg28_12"
                     /transl_table=11
                     /translation="MGIILATAGHVDHGKTTLIKKLTGIDTDTTEEEKKRGLTINLGFA
                     HLKLPNKSTIGIVDVPGHEKFLKNMLSGLSGIDAALLVVDPNEGVMPQTIEHARILLLL
                     GVTKFIVVITKVDTVDKDMVELVHEDIKESFSGTPIEKAEFFDVDAVSGTGVTDLVQGI
                     QKLCSSIDNTDISGYPRLNIDRSFSLKGIGTVVTGTLQDGNLSLDDKLILYPQEKEVNI
                     KNIRVYEGNTTSAQYSTRTALNIALPSETFHRGDVLATPNTIEIVDRINVVCDILSIPD
                     LDLKLNDRVRVYMGSKEVYGRIYPLGKNEIIPGETNFLQIRLEDNIAVRYQDKFILRSY
                     SPIKVIGGGRVLEMNPTNKRRFDSDTLKRLEIRLENQCTDVVLEYFISNNIITVDKNHL
                     SKYFNYSIEKVQNAIDELVSRKHLAKFGNEYLVIDVIENKNKEVLEFLDQYHGKYPLRK
                     GIALAEIRSKYFKEYTESDFENFVNFNIEEKILKKEGSLLSRFEFKVELNNHQKKNVDY
                     LLGILDKEPFIPQKINDVANSEELKELIFISPNDYFVNLDNEFVLSKKAFLKLEQKIID
                     YINKNEKLSLADYRDITNSSRRYAMIVLEKMDSLNITTRKENYRVLGDKANVL"
     CDS             11229..12368
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg28_13"
                     /sec_met_domain="Aminotran_5 (E-value: 6.6e-83, bitscore:
                     272.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYFDNAATTVVKPTQVAEAMFKVISSQKYGNPSRGSHEYAINSLS
                     IVNKCRQNIKKLFGLREEDEVVFTANATEALNIAIKGTLSEGDHVLATELDHNSVLRPI
                     YQLEKIGVEHDFVGLKDGVLDYEQLEEKVKSNTKVLVCTHASNVTGELLDIKLLSDFCK
                     KHKLTFILDASQTAGVIPINMLEQDIDILCFTGHKSLYGPQGIGGLCFKEGITIDPLIT
                     GGSGIDSFNHSQPNVYPEKLEAGTLNVVGIAGLNEGIEYILNKGIEDIRKIVATNVNRF
                     IDALEQMDNVILYTQRKRPVAGVVSLNIGNIDSETISDVLVEDFDIAIRPGAHCAPLVH
                     KALGTEKQGIVRFSFSSFNTIEEVDFAINAIKTIVTEVD"
     CDS             12369..13769
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg28_14"
                     /sec_met_domain="Aminotran_5 (E-value: 4e-08, bitscore:
                     26.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNSVQLVLRQIPSVNKILQDSVMKSMIADYGEKLVKISINSVLG
                     EIKSNILNGLVDNIPNYDDIVNQIKVEVNSKALPSLRKVINGTGIILHTNLGRASLPEN
                     VLNQMQRIASGYSNLEFDLETGKRGSRYAHVAGLISKITGAEDAVVVNNNAAAVMLVLS
                     TLASKGDVVISRGELVEIGGSFRVPEIITSTGGNLVEVGTTNKTHLNDYAEKINEETTA
                     LLKVHTSNYKVIGFTEGVSTQELHQLAKENNLPLIVDLGSGLLVDLSKYINYKEPTVQE
                     MVKNSDIVTFSGDKLLGGPQIGVIAGKKKYIDKIKKNQLLRALRVDKLTLSSLEIILRE
                     YYLKDEKELLASIPVLKKLTESSDNLEQKAKDLLTILKANDKLNLKIIEDYSEVGGGSL
                     PGLELPTYLVAIKAEGVSINKLESRLRKIDIPIIGRTIKDYFCLDLRTIEENEYEIIKD
                     ELCRIISN"
     CDS             13784..14104
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FeS_assembly_P"
                     /gene_functions="other (smcogs) SMCOG1048:Iron-sulfur
                     cluster assembly protein (Score: 70.4; E-value: 3.8e-22)"
                     /gene_kind="other"
                     /locus_tag="ctg28_15"
                     /sec_met_domain="FeS_assembly_P (E-value: 1.2e-21,
                     bitscore: 70.4, seeds: 42, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKTKEELVDDIYGNLEKVVDPELGIDIVNLGLIYNIDIDDNGKA
                     IVTMTLTTIGCPISELLEEAIRMQVLKVENVNECEINIVWEPAWDVSKMSRFARLSLGI
                     HI"
     CDS             14216..15526
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Complex1_51K"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RnfC_N"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg28_16"
                     /sec_met_domain="Complex1_51K (E-value: 5.9e-33, bitscore:
                     107.6, seeds: 88, tool: rule-based-clusters)"
                     /sec_met_domain="RnfC_N (E-value: 1.1e-15, bitscore: 51.1,
                     seeds: 53, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKIVLPLKQSVGTKADPIVSEGDVVKRGQLIAQPSGLGVNLHAS
                     LDGTISEITDDTITIIPNLEQSGDYVRIPDTEDNLEAIKEAGIVGCGGAGFPAYAKYGT
                     KIPDGHLFINAAECEPILGHNISRIITDAEKIIRGIEYVKEIVGAKDVQIAIKHKHTNA
                     VALLEEAIRGHKDISLELMKNRYPEGEERAIIRDSNLHKLLKTTDLPYAANAIVTNVET
                     VFRVAEAIEDRKPVMTKDITVGGRLNGDNETVVVRKDVPLGMLVKDILAAYPDMADYGE
                     LIMGGPFTGKRTSLDSPITKVSGGIIATIPFPNVKGQKVGLLACACSATPARMKEIAES
                     MGANAVGVEWCKNAVVNEKTGTAKCLNPGICPGQAATVLKLKAKGAEALLIGNCTDCTN
                     TVMGIAPKMDMPVYHVTDFARRATGERIMRHMLPEND"
ORIGIN
        1 atagaataaa taagaaacaa tttatcgatt ttgtatcatt aatcgataaa ttgttttttt
       61 tatatagaaa aagaaaaacc ggagttaact tgtaaccccg gctcataatc ggcttataac
      121 cttttcatta tctatatggc gggaaagtgt aggaatcgaa cctacccaag aagctcttaa
      181 ctcctcatac tggttttgaa gaccagaggg aacaccagaa cccatccatt cccattcgat
      241 atgatagcat aatatgtgaa ttattgcaaa ttataacatt taaaaattac attgaaatat
      301 tttttgatag tgatataatt aacatgcaat attgggaaaa cgtgtacatt taccctatat
      361 gtggaatatt aatacttact aaaataatat atatgttact caatattgca attaaactta
      421 tagaagttag gaggaaattc tatgtcaatt tcagttgaac aagctaaaga acatgctaag
      481 gatccagcag ttctttgctg tagaagagag gcaggaaaag ttctggaagc tgccgatttt
      541 gaagacccaa ctttgtttga tgactatgtt agttcaggac ttttagaaat acctgaagat
      601 acgttaacta ttgaacaagc attgggtgca acattaaata ctactacgga tgcattaaat
      661 cctttagttc caggtattgt agataatatt cagggaaatg aagaagcatc tgaaagtgat
      721 aaggacgaaa atgttgaaga agaaacacca gttgtagcag aagctaacaa tgaagtagta
      781 aattcaacat catcaaatgg tacattccat ttaagaatcg ctaaaggtga aggtattgat
      841 ttagaaatac ctttggatgt attaaaaaaa aacacagcta actcagctgt agatgtcccc
      901 aaggcggaaa caagtgctga tgtaactaat aaggatgttg cagaagatga agaatcagca
      961 gaagatgcta aagttgttcg tactctaact aaaaaatact tcaaagtaga tgaagttaaa
     1021 tttggagaca caacaaagtt tgatggaaca acactttact tacgtaatcc taaagaactt
     1081 tgcaaagaag ctgttgatac tgaagcaatc gttaagggta tggaaatcga aattatcaca
     1141 cctgatgatt attccaacta tagtaacact attatggatg ttcaaccaat cgctacaaaa
     1201 gaaggagata gtgatttggg tgtaggcgtt acaaaagttg tggatggtgc tgtagtagta
     1261 ctcacaggta ctgatgaaaa tggtgtccaa gttggtgaat ttggttcttc agaaggtcca
     1321 ttgaatgaaa atattatgtg gaatcgtcct ggtgcagttg ataaaggcga aatcatgatt
     1381 aagattgatg ttgttatcga agctggaact aaccgtgaac gtaaaggacc tttaggagca
     1441 catttagcag cagactacat tacacaagaa attagagaag cactaaaaga tgttgatgat
     1501 agttcagcag ttagaactga agaatttgtt caaaaacgtc atcctaagca aaagagagta
     1561 ttaattgtaa aagaaatcat gggtcaaggt gcaatgcacg ataatttaat tatgcctgtg
     1621 gaaccagttg gtactcttgg tgcaaagcca aatgttgatt taggtaactt gccagttgta
     1681 ttagctccaa cggaattatt agatggtggt gtacatgctt taacatgtat tggacctgct
     1741 tctaaggaaa catccagaca ttacttcaga gaacctttgg tagaagaagc aatggctgat
     1801 gaagatattg atttagttgg tattgcatta gtcggttcac ctcaagaaaa tgttcaaaaa
     1861 ttctatgttt ctaagagatt aggtatgatg gtagaagcta tgaatttaga tggtgctatt
     1921 gttacaacag aaggatttgg taataaccat atcgactttg cttctcacat cgaacaaatt
     1981 ggtgaaagag gagtagatgt tgttggaatg acatatgctg ctgtccaagg acaattagtt
     2041 gttggtaaca agtatatgga tgcaatggtg gataacaaca aatcccgtca aggtattgaa
     2101 aacgaaattc ttgaaaacaa tactctatca cgtgaagatg ctatcagagc tttagcaatg
     2161 ttggaaacaa agatggctgg tggatcaatt aagaaacctg aacgtcaatg gaatccaaat
     2221 gttaagcaaa ataatatcga aattattgaa aaagaaaccg gtaagaagat tgacttagtt
     2281 gagaatgaac aatctctacc aatgagtaag aagcgtcgtg aaatttacga aaaggatgct
     2341 caatagtatg gaagaacaaa gtacaggatt tgacaagttg aaatatgcct caactgaaag
     2401 agtatgggag ggcataataa tagaattgac agatgcgagt gtcataattg atcttaaagg
     2461 acgtctaggt agactagaaa ttcctaatag aatgattatt agtgactatg agttgaaagt
     2521 cggtcaggaa gtagcattct taatgtcata tcccgaagtt ttggatagtg aacctaatca
     2581 aaaatattta ggagcactaa atgcatacca taaaaaaatg aaagaaataa aagaaaagca
     2641 aaggagagat aaaaatgagt cttaagaaat atgatggact acaatccgaa atatttgtac
     2701 ctattactcc tacgccagtg tgggctccag ttaaaaagaa gctaaaagat atgactgtag
     2761 caattgtaac tgctgctggt gtacatttga aatcagataa accatttaat ttagctggtg
     2821 atacttcata tagagtagta ccttcaactg caactgatga tgaattgatg gtatcacatg
     2881 gtggttatga taacactgat gttaacagag atattaactg tatgttccca attgatagat
     2941 taagagaact tgcagagaaa ggatttatta agaatattgc gccaaacatg tatacatgta
     3001 tgggtggtgg tggagacgtt aaagtcttta ctgaagaaac tggtccagaa attgcccaaa
     3061 aattattgga tgaacatgta gatgctgtcg taatgactgc tggttgaggt acctgtcata
     3121 gaactgccgt gatcgtgcag agagctattg aatcagttgg tatcccaaca attattattg
     3181 cagccttacc tccagtagta cgtcaacaag gatctcctag agctgttgct cctcgagttc
     3241 ctatgggggc taatgccgga gaaccacaca acgtcgaaat gcaaacaggt attttgaaag
     3301 atacgttaga gcaattagaa aaattagatt ccccaggtaa gattgtgcca ctaccatatg
     3361 aatatatagc aaatatatag ttatattgga agtgttatta tgtcagatga tattttaaaa
     3421 atcagagaat tccatgtaaa agatgtagtt tttggagatg gatactcttt taaggatagt
     3481 gttttaacta tacctcaaag tgtaaaattt gatttaccta aagaaatatt gtcgataaat
     3541 attaggataa taaaaaaaga taatcgtcat ttaaaggtta actctattat ggatattata
     3601 cctatatcta ctaaagttag tggaaagata gggactggag tttctcatac attaacaggt
     3661 gtagaggtta tgttgactgg tgcttcagca agtggtatcc aaatacatga ttttggatct
     3721 tccgatggat atttagatga aaaaatggtt tttggaagaa acggtacgcc tgatgaggat
     3781 gacattatca taggcctaga tgttataact gctgaagatt atagtctaga tcgtgcagtt
     3841 atcactaaaa tttttgaatt ggttgatgat tttatacaac ctattcgaaa gattttgaaa
     3901 gtaaccaatg gacgttatgc tgattatgta ggtgaatata ggaataatgt ttcaaatggt
     3961 aagcctaaag tagtagttat taaacaagtt tctgggcaag gtgctatgta tgacaatatt
     4021 ttatttccta atgagccttg tggtataaaa ggtggagttt cgattattga tatgaataac
     4081 tttccaacaa tagtaactcc aaatgagtac cgtgatggca taatacatgc attagtttaa
     4141 ttagatggaa gtgatgtttt atgggtgttg gtccttcaac taaggaaact acattacatc
     4201 attatcatga tccgttagta aaagtttttg gcgatgatcc agatattgac tttcaaggtg
     4261 ttgttatagt gggaacacct caagataaca agttaaaaga agaagttgga tatagagttg
     4321 ctaaattctt aaaagctatg agaactaatg gtgcagtaat ttctgctgac ggatggggaa
     4381 actctgatgt ggattttatg aatactattg aatctatagg tgatgaaggt atctcaatta
     4441 ttggattgaa atttattgga actcaagcaa cattcgttgt atcaaatgaa tatacaccat
     4501 atgttttaga tataaataaa tctgaaaagg gtatagaaac aacagttgtt ggggaaaata
     4561 atttagatga acgagatgca cataaagcct taggatattt aaagcttaaa atgcgttcag
     4621 atggtaattc ctgatgaact acgaagaagg taaggtttat gagattatca caaatgttga
     4681 atgtgattga ttcccataca gcaggagaac cagcaagaat tgttgttggt ggaattcctg
     4741 ttttaaaagg gaaaacagtt gctgaaaaga aacaatattt gattgatcat aaagataatt
     4801 taagaaaatc tatcatgctt gaacctagag gacacaatgc aatgtttgga gcatttttga
     4861 tcccagctat aagtgatgaa gcagatttcg gcattatttt tatggatact ggtggatatt
     4921 taaatatgtg cggccataat actattgctg cagttacagc tatagtagaa actggaatgg
     4981 ttgacgtaga tgaagacacc agagaaaaag atgtcacatt agaaacacca gccggtttgg
     5041 tgcatgcaac agcacattta gattctccat atcatgtgaa gaatgtatcg tttagaaatg
     5101 tacctgcatt tctatataag aaagatgtag ttgttgatgt tccagacgtt ggtaaagtaa
     5161 aaatggacat ttcatttggt ggtagtttct ttgcaatatt agatatagag cagttaaatg
     5221 aaactattga tagtagtaat gcagagaaac ttgatagcat cggaatgaag atcctaaagg
     5281 ctgttaatga acaagtaaaa gttcagcatc ctactttaga ttatatcaac acggttgatc
     5341 tggtagaaat gtacagcaag catcctcaat ctgaagatgc aactatgcaa aatgtagtag
     5401 tttttggtga tggtcaagtt gatcgttctc cttgtggtac aggtactagt gctaaattag
     5461 caactttatt tgctaaagga gaaataggca ttaacgaaaa gtttgtttac gagagcatct
     5521 taaacactga atttaccgga aaagttgtag aaaaggtaaa tattggtggt gttgatgcaa
     5581 ttacgcccga aattacaggt tcagcatatc ttacaggctt caatacgcta ttatttgatc
     5641 ctagtgatcc gttaagtaat ggttttgaat tgaagtaagg atgtgattaa atgaatctag
     5701 tattagtaat tcaaataatt ttaggagtat gtctagtatt ctttacaatt atttggttga
     5761 aagatttaat taagaataaa aataagttaa atgatggtaa tttactttta gctggtgtaa
     5821 taggctttgt tactaacttt tttgatacgt taggaattgg tagttatgca ccaactacaa
     5881 tgttgttgaa actaactaaa tatatgaaga acgataagtt attgccaggt actttgacaa
     5941 ttgcttgttc aattcctgtt ttaacagagg cttttctcta tattaatact gtaaaagtag
     6001 aagcagcaac tttactgtca ttgattgtcg ccgcatcagt gggctcattt ttaggatcta
     6061 agtttatttc tcgtatagat gaaaagaaaa tacaagtaat gatgggtttt gcgttaatca
     6121 taaccgcaat tttaatgtgc ctatctaata ctggtgtttt agcaagctta ggtaatggaa
     6181 atgttgcagt tggtttaaca ggatggaaac tatttattgg tatattaggt aactttatat
     6241 taggtgcttt aatgacagca ggtattggct tatatgcacc ttgtatggca atggtttact
     6301 tactaggttt gtcaccatta gtagcctttc cgataatgat ggcatcctgc gcagttttaa
     6361 tgccagttgc aagtagagag ttcataaagg atggtaatta caatagaaat gctactattg
     6421 gaattactat tggtggtata ttaggtgtat ttgtcgcagt tactcttgtt aagagtatga
     6481 gtttaacttt actaacatgg ttagtcataa ttgtgttaat ctatacggca attacaatgc
     6541 ttatgcaagg atttaaaaaa gaagcataat gtttgagggg ctctttatta catatattat
     6601 tgatatgtaa tagaggccct tcgtgtatat atagttagaa aaagcgaaag atatgtgata
     6661 atttatgaaa aataaaaaga aaataagtct tttttcaggt gttatgctag ctttgagttc
     6721 gctgatcggt tctggatggt tatttggttc agaacaagca gctaaagtag caggaccagc
     6781 cgcaataata tcttggatta ttggggcaat aataatgatg gttattgctt ttaactatgt
     6841 agaattggga acaatgtttc ctgaaagtgg aggaatgagt agatttgctc aatatagtca
     6901 cggttcattt ttaggtttta ttgcagcatg gggtaattgg gtttctttga ttacattaat
     6961 tccgatagaa tcagttgctg cagttcaata catgagttcg tggccatggt cttgggcaaa
     7021 ttggacagct aaattctttc atggaagtag tataacaaca caaggattat taatggtgta
     7081 cttatttatg attgtattta cacttattaa tttttggtct gttagaattt taacgagatt
     7141 tacaagttta atctctttct ttaaattgat agttccgaca ttaactataa ttgttttact
     7201 agttgaggga tgtcatcctg gaaattttgg tcatagtgtt tctacattta tgccttatgg
     7261 aacaagttcg atttttgaag caacaactgt ttctggaatt atattatcat acgatgcatt
     7321 tcagactgtt ataaatatgg gtggagaaat ggaaaaacca gaaaaaaata ttctacgtgg
     7381 aatagtaatt tctttaacca tcactgctct gatttatatc atgttgcaag ttacatttat
     7441 aagtagtgta gacccaagat tgattgctag tgtaggttgg aaaggaataa gttttacatc
     7501 tccatttgct gatattgcga tcttattgaa tttaaattgg ttatctatat tactatatac
     7561 agatgccttt gtctcaccat ttggaacagg agtagcattt gtagcaacat ctgctcgtac
     7621 tttgtctgca atgactaaaa atggtacagt tcctccagtt ttaggaaagt taaacaaaaa
     7681 atacggcata cctagatatg cgatggcagc agatttaggc ttagcgatga tattagtctt
     7741 tttctttaga gattggagta aattagctac agttgtatca atatcaactt ttatagccta
     7801 cttaacaggg ccagtatctg ctgtagcatt aagaaaactt cgtccgaact ttaagagacc
     7861 atttaaatca aattggctat atgttttagc tccagtttct tttgtactca caagtatggt
     7921 tatatactgg gcaatgtggc caacaactgt agaagtaatt tttgtcgtat tattaggact
     7981 accactttat ttctactatg aatctaaaaa tatgcgaact acatggaaag aacaattaca
     8041 tggtggtttg tggatggtag tatatttaat tttcatctca ctaatgtcat attttggtag
     8101 taaaggatat ggtggaaata acacgataaa atatccaatg gattttgtga tagttatagt
     8161 aggatcatta attatttatg tgtgggcagt tgcaagtaga atagataatc cagacttaga
     8221 tgatgcagaa aaattaaata atactgtaaa aagtgaaaat taaaaattac attaaaaaat
     8281 ttttatttat atatatgagt agtagtgtta aaatgatagc gtaaacataa ttgatattag
     8341 gaagtgtatg tagttatgag aaaagtagat gctttagggt tagaatgtcc tattccagtt
     8401 gtaaaaacta aaaaagcctt ggaagaagat gacgttgttg aagttttggt agataacgat
     8461 acatctgtaa aaaatttaga gaaaatggct aaacaaaagg aatatggctt taaggttgat
     8521 aaagaagaaa atcattataa gataacgata tctaaaaata atgatactga aacagcagtt
     8581 gaagagaaac ataagaatga aaaaattatg aaatcaacaa tagaagatat aacatttgaa
     8641 tcacctaaag gatatattgt agttattaac acagacagtg ttggtcatgg tgatgaaaaa
     8701 ttaggaaaaa ttcttttaaa gagtttcatt tattcattaa cgggtcaaga tgtcttacca
     8761 gaatatattc tcttatacaa cggtggagta aaactaactg ttgaagattc cgattctttc
     8821 caagatttaa aagatcttga agaagctgga gttaaaatta tgtcttgtgg tatttgtctt
     8881 gactactacg atttgaaaga taagatgagt gttggtgaag ttacaaatat gtttagaatt
     8941 gtagaattaa tgagaactgc aaacagagtt gtaagaccat aatttaataa tttagatgaa
     9001 agatgagaat ttatttttaa aaagtctcat cttttagtct ataaaacata tgctcgaggt
     9061 gactagattt gaaaaaacag ccttttacaa tgatagtatt caattctact catgcagcta
     9121 tagaggctag cgagatttta aaaaataata agcaagttaa tagaattgtt aatacacctg
     9181 gaaaaattga gaatggatgc ggattaagta tttatgtaaa tgatacgaat attgataaga
     9241 tcacagaacc cattcaaagt ttttttgatg ataaaaaggt aaaagctatt tatagcggtg
     9301 aaaaagaggg gctatcaaga agttatacat tagttaagga gatttgatga tgggaatcat
     9361 attagctacg gcaggacatg tggatcatgg aaaaacaact ttaataaaga aattaacagg
     9421 tattgataca gatactacag aagaagaaaa gaagcgaggt ttaacaataa atttaggttt
     9481 tgctcattta aaacttccaa ataaaagtac aattggaatt gtagacgttc caggacatga
     9541 aaaattttta aaaaatatgc tttctggttt atcaggtata gacgcagctt tattagtagt
     9601 cgatcctaat gaaggcgtta tgccacaaac gattgaacat gcaagaatac tattgctact
     9661 cggtgtgact aagttcatag ttgtaattac taaagtagat acagttgata aagatatggt
     9721 agagctagtt catgaagata tcaaagaaag ttttagtgga acaccaattg aaaaagctga
     9781 gttctttgat gtagatgcag taagtggtac aggagtaact gatttagttc aaggaataca
     9841 aaaattatgt tctagtattg ataacacaga tatttctggt tatccacgtt tgaatattga
     9901 cagatcattt tctttgaagg gtattggaac agttgttact ggtactttgc aagacggaaa
     9961 tctatcctta gatgacaagt tgatattata tcctcaggaa aaagaagtaa atattaaaaa
    10021 tattcgtgta tatgaaggaa atacaacttc tgcacaatat agtacaagaa cagcgttaaa
    10081 tattgctttg ccttctgaaa cttttcatcg cggtgatgta cttgcaacac caaacactat
    10141 agaaattgtg gatagaataa atgttgtatg tgacattctt tcgataccag atttagattt
    10201 aaaattaaat gatagagtcc gtgtatatat ggggtctaaa gaagtttacg gaagaatata
    10261 cccactaggt aaaaatgaga ttatacctgg ggaaacaaat ttcttacaaa taagattaga
    10321 agataacata gctgtaagat atcaagataa atttatttta agaagttatt ctcctattaa
    10381 ggtgataggt ggaggaagag tattagagat gaatcctact aataagcgta gatttgactc
    10441 tgatacactt aagcgactag aaataagatt ggaaaatcaa tgtacggatg tagttttaga
    10501 atattttatt agcaacaata taataactgt agataaaaat catttgagta aatacttcaa
    10561 ttattcaata gaaaaagtgc agaatgcgat agatgaattg gtatcaagaa agcatttagc
    10621 aaaatttggt aatgaatatc tggtaataga tgtcatagag aataaaaata aagaagtatt
    10681 ggaatttcta gatcaatatc atgggaagta tccactaaga aagggtatag cacttgccga
    10741 aattagatct aaatacttta aagagtatac tgaaagtgat tttgaaaatt ttgttaattt
    10801 caatattgaa gaaaaaattc tgaaaaaaga aggttctttg ttatctagat tcgaatttaa
    10861 agttgaatta aataatcatc aaaagaagaa tgtagattat ttactaggaa ttttagataa
    10921 agagccattt attccacaaa agataaatga tgtagctaat agtgaggagt taaaagaatt
    10981 aatttttatt tctcctaatg attactttgt aaatctagat aatgaatttg ttctaagtaa
    11041 aaaagcattt ttgaaattag agcagaagat tattgattac attaataaaa atgaaaaatt
    11101 aagtttagca gattatcgtg atattactaa ttctagtaga agatatgcga tgattgttct
    11161 tgagaaaatg gatagcttaa atatcaccac aagaaaagaa aactatcgtg tgttagggga
    11221 taaggcaaat gtactttgat aatgctgcta cgacagtagt aaaacctaca caggttgctg
    11281 aggcgatgtt caaggtaatt agcagtcaaa aatatgggaa tccttctagg ggatcacatg
    11341 agtatgctat taattctttg agtattgtta ataaatgtcg acagaatata aaaaaattgt
    11401 ttgggttacg cgaagaggat gaagttgtat ttacagcaaa tgcgacagaa gctctcaata
    11461 tagctattaa aggaacttta tctgaaggag atcatgtttt agcaactgaa ctagatcata
    11521 attcagtttt gcgaccaata tatcaattag aaaaaattgg tgttgaacat gattttgttg
    11581 gtttaaaaga tggagttctg gattatgagc aactagaaga aaaagttaaa tcaaatacta
    11641 aagttttggt atgtacccat gcttctaatg tgacaggaga attgctagac attaagttgc
    11701 taagtgattt ttgtaagaaa cataaactaa catttattct agatgcgtca caaacagctg
    11761 gagttattcc aattaatatg ttggaacaag acatagatat tctttgtttt acaggacata
    11821 agtccttgta tgggccacaa ggaataggtg gattatgttt caaagaggga ataacaattg
    11881 atcctctaat tacaggggga agtggaatag attcatttaa tcattctcag ccaaatgtat
    11941 atcccgaaaa attagaagca ggaacgttaa atgttgtagg aattgcaggt ttgaatgaag
    12001 gtattgagta tattttaaat aagggaattg aagatatacg aaaaatagta gctactaatg
    12061 ttaatagatt tatagatgca cttgaacaaa tggataatgt cattctttat acacaaagaa
    12121 aacgaccagt tgcgggggta gtatctctaa atattggaaa tattgattcc gaaactataa
    12181 gtgatgtgtt ggtagaggat tttgatatag ctattcgtcc aggggctcat tgtgctcctt
    12241 tagtacataa agctttagga actgagaaac aaggaattgt aagattctca ttttctagtt
    12301 ttaatacgat tgaagaagtt gactttgcga ttaatgcaat caaaacaata gtaacagagg
    12361 tagattagat gaataattca gtacaattag ttttaaggca gattccgtca gtgaacaaaa
    12421 ttttgcaaga ttcagtaatg aagagcatga tagctgacta tggagagaaa ctagtaaaaa
    12481 tctccataaa ttcagtatta ggagaaataa aatctaatat tttaaatgga ttagtagata
    12541 atattcctaa ttatgatgat attgtgaatc agataaaagt tgaagttaat agtaaagcat
    12601 taccatcttt gagaaaagtg attaatggta caggaattat tctccatacg aatcttggca
    12661 gagcatcttt gccagaaaat gtactaaatc agatgcagag aatagctagt ggatattcga
    12721 atttagaatt tgatttagaa acaggaaaac gtgggagtag gtatgctcat gtagcaggtc
    12781 tgataagtaa aataacaggt gccgaagatg cggttgttgt taataataat gctgctgctg
    12841 ttatgttagt gttgtcaact ttagcttcta agggcgatgt ggttatttca agaggtgaat
    12901 tagtagaaat aggaggatca tttagagtgc ctgaaattat aacaagtact ggaggaaatc
    12961 tagttgaagt aggaactact aataaaactc accttaacga ttatgctgaa aaaataaatg
    13021 aagagacaac ggcgttatta aaagtgcaca ctagcaatta taaggtaatt ggttttacag
    13081 aaggagtatc aactcaagaa ttacatcaat tagctaaaga aaataattta cctttaattg
    13141 tagacttggg gagtggcttg cttgttgatt taagtaagta cataaattac aaagaaccaa
    13201 cagttcaaga aatggtaaaa aatagtgata ttgtaacttt ttctggtgat aaattacttg
    13261 gtggtcctca aattggagta attgctggta aaaagaaata tatcgataaa ataaagaaga
    13321 atcaattatt gagagcttta cgagtagata aattaacttt atcatcgcta gaaataattt
    13381 taagagagta ttatttgaaa gatgaaaaag aattgttggc atcaattcca gttttgaaaa
    13441 aattgacaga atcttctgat aatttagaac aaaaggctaa agatcttcta acaattttaa
    13501 aagcaaacga caagttgaat ttaaaaatta ttgaagatta ttctgaagtt ggtggaggaa
    13561 gtcttccagg tttagagttg ccaacatacc tagttgctat taaagcagaa ggtgtatcaa
    13621 ttaataaatt agaaagtaga ttaagaaaaa ttgatattcc gattataggt agaactataa
    13681 aagattactt ctgtttagat ttaagaacta ttgaagaaaa tgagtatgaa ataattaaag
    13741 atgaactttg taggataatt agcaattaat aaggatgatt attatgaata aaacaaaaga
    13801 ggaattagtc gatgatatct atggaaatct agaaaaagtt gtcgacccag aattaggtat
    13861 agatatcgtt aatttaggat taatttataa catagatatt gatgataatg gcaaggcaat
    13921 tgtaacaatg acattaacaa caataggttg tccaatttca gagctactag aagaagcgat
    13981 tagaatgcaa gttttaaaag ttgaaaatgt taatgaatgt gaaataaata tcgtttggga
    14041 accagcgtgg gatgtctcaa aaatgagtag atttgctcga ttaagtttag gaattcacat
    14101 ttagttaaag aactattagt ttttatgaaa acaattgcaa atgcccttga tagtgatata
    14161 ctgtacatgt aagtatgtaa tattccacat gagtaattga agggagtagt ccaatatgga
    14221 aaagattgtg ttacctctca aacaaagtgt tggaacaaaa gctgatccaa ttgtatcaga
    14281 aggcgatgtt gtaaaaagag gacaattaat tgcccagcca tctggactag gtgtaaattt
    14341 acatgctagt ttagacggaa ctattagcga aattacagat gatacaatca ctattattcc
    14401 taatttggaa caaagtggtg attacgttcg cattcctgat acagaggaca acttagaggc
    14461 aattaaagaa gctggtatcg tcggttgtgg tggcgctgga tttcctgcat atgctaagta
    14521 tggaacaaag attccagatg gtcatttgtt tatcaatgcg gcagaatgtg aacctatctt
    14581 aggacataat atttcacgta ttattactga tgctgaaaag attatcagag gtatagaata
    14641 cgttaaagaa atagttggtg ctaaagatgt tcaaattgct attaagcata agcatactaa
    14701 tgcagttgct ttattagaag aagcaattag gggacataag gatatttcat tagaattaat
    14761 gaaaaataga tatcctgaag gcgaagaacg tgccattatc agagattcta acttgcataa
    14821 attgctaaag acaactgatt taccatatgc tgcaaatgct attgtaacta atgttgaaac
    14881 tgtcttccgc gtagcagagg ctattgaaga tagaaaacca gttatgacaa aggatattac
    14941 agttggtggt agattgaatg gtgacaacga aaccgtagtt gtaagaaaag atgtgccatt
    15001 aggaatgttg gtaaaagata ttttagctgc atatcctgat atggcagatt atggtgaatt
    15061 aatcatgggt ggacctttta caggtaaaag aacctctctt gattcaccaa ttactaaggt
    15121 ttcaggtggc attattgcaa caattccatt ccctaatgtt aagggacaga aggttggatt
    15181 gttagcatgt gcctgcagtg ctactccggc aagaatgaaa gaaattgctg aatctatggg
    15241 tgcaaatgct gttggtgttg aatggtgtaa gaacgctgtg gtaaatgaaa aaacaggtac
    15301 agctaaatgt ctaaatcctg gtatttgccc aggacaagca gcaacagtat tgaaactaaa
    15361 agccaagggt gcagaagctc tcctaattgg aaattgtact gattgtacta atacagttat
    15421 gggaattgca cctaagatgg atatgccagt ttatcatgtg actgattttg cacgtagagc
    15481 aacgggcgaa agaattatga gacacatgtt gccagaaaat gactaattat ccaaagtcca
    15541 attaaaagag gtgaaagagt aatgtcagat aaagataaga acaaaaactt aattatttgt
    15601 ggtggttgaa actctaagat gggtccggcg gatctttatg gtattttaga gaagttacct
    15661 caaaaaaagg atgaaaac
//
