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Overview
1.1
1.2
1.3
1.4
1.5
2.1

### Identified secondary metabolite regions using strictness 'relaxed'

gnlProkkaCMAHBEIB_1 (original name was: gnl|Prokka|CMAHBEIB_1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | RiPP-like | 202,310 | 221,670 |
Region 1.2 | RiPP-like | 800,229 | 812,325 |
Region 1.3 | RiPP-like | 836,160 | 848,316 | ubericin K | Other | 12%
Region 1.4 | RaS-RiPP | 1,264,148 | 1,286,572 | streptide | RiPP | 100%
Region 1.5 | T3PKS | 2,108,816 | 2,149,982 |

gnlProkkaCMAHBEIB_2 (original name was: gnl|Prokka|CMAHBEIB_2)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 2.1 | lanthipeptide-class-iii | 49,901 | 72,465 |

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | RiPP-like | 202,310 | 221,670 |
Region 1.2 | RiPP-like | 800,229 | 812,325 |
Region 1.3 | RiPP-like | 836,160 | 848,316 | ubericin K | Other | 12%
Region 1.4 | RaS-RiPP | 1,264,148 | 1,286,572 | streptide | RiPP | 100%
Region 1.5 | T3PKS | 2,108,816 | 2,149,982 |
Region 2.1 | lanthipeptide-class-iii | 49,901 | 72,465 |

Compact view
gnlProkkaCMAHBEIB_1 - Region 1 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 202,310 - 221,670 nt. (total: 19,361 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
KnownClusterBlast
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

gnlProkkaCMAHBEIB_1 - Region 2 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 800,229 - 812,325 nt. (total: 12,097 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
KnownClusterBlast
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

gnlProkkaCMAHBEIB_1 - Region 3 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 836,160 - 848,316 nt. (total: 12,157 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
KnownClusterBlast
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
gnlProkkaCMAHBEIB_1 - Region 4 - RaS-RiPP
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,264,148 - 1,286,572 nt. (total: 22,425 nt) Show pHMM detection rules used
RaS-RiPP: (PF04055 and TIGR01716)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
KnownClusterBlast
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
gnlProkkaCMAHBEIB_1 - Region 5 - T3PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,108,816 - 2,149,982 nt. (total: 41,167 nt) Show pHMM detection rules used
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
KnownClusterBlast
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

gnlProkkaCMAHBEIB_2 - Region 1 - lanthipeptide-class-iii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 49,901 - 72,465 nt. (total: 22,565 nt) Show pHMM detection rules used
lanthipeptide-class-iii: (micKC and not PKS_KS)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
KnownClusterBlast
Lanthipeptides
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for ctg2_55

allorf_063635_063754
Leader:
MKNILSLQQLKVKENTKLMAK
Core:
S S K S I N C K N S S H A S W F V C
Core with dehydrations:
Dha Dha K Dha I N Cys K N Dha Dha H A Dha W F V Cys

#### antiSMASH-DB 4.0 matches for allorf_063635_063754

61.1% NC_013164.1: Lanthipeptides: APRE_RS09655_lanthipeptide
4
S I N C K N S S H A S W F V C
18
S N C K N S S S F V C
3
S T N C K N S S G I S L F V C
17
55.6% NC_013164.1: Lanthipeptides: APRE_RS09840_lanthipeptide
4
S I N C K N S S H A S W F V C
18
S N C K N S S S F+C
3
S T N C K N S S G V S L F I C
17
55.6% NZ_CP026031.1 and 4 others:
NZ_CP026033.1 Lanthipeptides: C2H98_RS25970_lanthipeptide NZ_CP026040.1 Lanthipeptides: C2I17_RS08935_lanthipeptide NZ_CP053315.1 Lanthipeptides: HLK66_RS26225_lanthipeptide NZ_CP053989.1 Lanthipeptides: FOC77_RS25275_lanthipeptide
Lanthipeptides: C2I06_RS25335_lanthipeptide
1
S S K S I N C K N S S H A S W F V C
18
S S S+ C S S+ S W F C
1
S S V S L G C S P S S N T S W F F C
18
with 12 more sequence matches
55.0% NZ_JAMYIV010000006.1: Lanthipeptides: allorf_139780_139899_lanthipeptide
1
S S K S I N C K N S S H A S W F V C
18
S S S I N C K S S F C
3
S S A S I N C K R K S T L S L F F C
20
52.6% NZ_CP024036.1: Lanthipeptides: CR091_RS27895_lanthipeptide
1
S S K S I N C K N S S H A S W F V C
18
S S S+ C S S+ S W F+C
2
S S L S L G C S P S S N T S W F L C
19
52.4% NC_013164.1: Lanthipeptides: APRE_RS09660_lanthipeptide
1
S S K S I N C K N S S H A S W F V C
18
S+ S N C K N S S S F+C
4
S T Y S T N C K N S S G V S L F I C
21
50.0% NZ_AXVK01000021.1: Lanthipeptides: K332_RS23900_lanthipeptide
1
S S K S I N C K N S S H A S W F V C
18
S S S+N C K S S+F+C
3
S S V S V N C K V I S T I S F F L C
20
50.0% NZ_JAQQWS010000001.1: Lanthipeptides: PQ479_RS00990_lanthipeptide
2
S K S I N C K N S S H A S W F V C
18
S S I+C K S S F+C
1
S L S I S C K K F S S L S V F I C
17
50.0% NZ_KV809437.1 and 2 others:
NZ_PNGL01000006.1 Lanthipeptides: CJ228_RS12250_lanthipeptide NZ_SPKT01000006.1 Lanthipeptides: E4A49_RS12090_lanthipeptide
Lanthipeptides: HMPREF2863_RS12160_lanthipeptide
1
S S K S I N C K N S S H A S W F V C
18
S S S+N C K S S V C
3
S S L S V N C K V I S T I S V A V C
20
50.0% NZ_NUFU01000017.1 and 2 others:
NZ_NUFU01000017.1 Lanthipeptides: CN902_RS28885_lanthipeptide NZ_VEAZ01000013.1 Lanthipeptides: FS498_RS29425_lanthipeptide
Lanthipeptides: CN902_RS28890_lanthipeptide
1
S S K S I N C K N S S H A S W F V C
18
S S S+N C K S S+ V C
3
S S L S V N C K V V S T I S F A V C
20
41.7% NZ_PIZP01000004.1: Lanthipeptides: CW747_RS14930_lanthipeptide
1
S S K S I N C K N S S H A S W F V C
18
S S S C S S+ S W F C
7
S S A S W G C A P S S N T S W F F C
24
36.4% NZ_AXVK01000021.1: Lanthipeptides: K332_RS24275_lanthipeptide
1
S S K S I N C K N S S H A S W F V C
18
S+ S C K S S F+C
1
S N L S F V C K K E S T L S L F L C
18
34.8% NZ_JAOPTJ010000013.1: Lanthipeptides: OCF64_RS23365_lanthipeptide
1
S S K S I N C K N S S H A S W F V C
18
S+ S+ C K S S F C
1
S N L S L V C K E K S T I S V F T C
18
33.3% NZ_AP018365.1 and 8 others:
NZ_AP018365.1 Lanthipeptides: allorf_8005631_8005744_lanthipeptide NZ_AP018365.1 Lanthipeptides: allorf_8005631_8005744_lanthipeptide NZ_AP018365.1 Lanthipeptides: allorf_8005631_8005744_lanthipeptide NZ_FONG01000023.1 Lanthipeptides: allorf_109527_109640_lanthipeptide NZ_FONG01000023.1 Lanthipeptides: allorf_109527_109640_lanthipeptide NZ_FONG01000023.1 Lanthipeptides: allorf_109527_109640_lanthipeptide NZ_FONG01000023.1 Lanthipeptides: allorf_109527_109640_lanthipeptide NZ_FONG01000023.1 Lanthipeptides: allorf_109527_109640_lanthipeptide
Lanthipeptides: allorf_8005631_8005744_lanthipeptide
11
S H A S W F V C
18
S A S W F+C
5
S D A S W F L C
12
12.8% NZ_KV797630.1: Lanthipeptides: allorf_070105_070269_lanthipeptide
7
C K N S S H A S W F
16
C N S+ W F
11
C V N S T E G F W F
20

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Lanthipeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

allorf_063635_063754 - Class III
  Cleavage pHMM score: 0.30
  RODEO score: 0
  Monoisotopic mass: 1875.9 Da
  Molecular weight: 1877.1 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1895.1 Da N = 1
    1913.1 Da N = 2
    1931.1 Da N = 3
    1949.2 Da N = 4